Egami Takuya 江上拓哉

… Alternative Names

Researcher Number	40507787
Affiliation (Current)	2020: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2014 – 2020: 九州大学, 医学研究院, 共同研究員 2013 – 2016: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学(系)研究科(研究院), 研究員 2011 – 2012: 九州大学, 医学研究院, 共同研究員 2011: 九州大学, 医学(系)研究科(研究院), 共同研究員 2009 – 2011: Kyushu University, 大学院・医学研究院, 共同研究員 2010: Kyushu University, 医学研究院
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Digestive surgery / Tumor biology and related fields / Basic Section 55020:Digestive surgery-related / Gastroenterology
Keywords	Principal Investigator 膵癌 / オートファジー / 膵臓外科学 / ウイルス治療 / エンドサイトーシス / アデノウイルス / 薬剤内包型人工ウイルス / Drug Delibery System / 治療耐性 / ウイルス … More Except Principal Investigator 膵癌 / 膵星細胞 / 癌間質相互作用 / 肝転移 / 微小環境 / オルガノイド / 間葉系幹細胞 / オートファジー / 膵臓癌 / 癌微小環境 / 膵癌微小環境 / 膵臓外科学 / EMT / miRNA / Redox / 間様系幹細胞 / microRNA / IPMN / drug delivery system / 人工ウイルス / 浸潤 / 上皮間葉移行 / 細胞外基質 / リーディングセル / コラーゲン / 上皮間葉転換 / desmoplasia / CD51 / perivascular cell / ミクロベシクル / マイクロベシクル / ギャップジャンクション / CD271 / CD146 / podoplanin / 線維増生 / インクレチン / GLP-1 / Pancreatic cancer / PSCs / Leading cell / ECM remodeling / Cancer micro environment / Normalization / 細胞外マトリックス / leading cell / 基質リモデリング / 間質リモデリング / 線維芽細胞 / CD110 / トロンボポエチン(TPO) / ERK / MYC / 癌幹細胞 / トロンボポエチン / DNAマイクロアレイ / NPAS1 / マイクロRNA / エクソソーム / PSC / phenotype switching / ３Dバイオプリンター / 癌関連線維芽細胞 / 3Dバイオプリンター / 基質リモデリング制御 / ゲノム不均一性 / 次世代シークエンサー / リキッドバイオプシー / NGS解析 / 遺伝子変異 / シングルセル解析 / heterogeneity / 次世代シーケンサー / 遺伝子変異解析 / KPCマウス / 隔離膜 / 小胞体 Less

膵星細胞抑制薬とナノ粒子の組み合わせにより間質障壁を打破する新規膵癌治療薬の開発Principal InvestigatorOngoing
- Principal Investigator
  
  江上拓哉
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
膵星細胞活性化遺伝子に着目した小胞体由来のオートファゴソーム膜起源の解明Ongoing
- Principal Investigator
  
  坂井寛
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
NGS解析による膵癌微小環境とゲノム不均一性の解明とその治療への応用Ongoing
- Principal Investigator
  
  進藤幸治
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Elucidating the mechanisms of pre-metastatic niche formation by pancreatic cancer exosomes
- Principal Investigator
  
  MIYOSHI Kei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Control of microenvironment involved in pancreatic cancer progression and defense by phenotype switching
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
The role of autophagy in perineural infiltration of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  EGAMI Takuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidation of leading cell and cancer microenvironment normalization of pancreatic cancer
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Management of pancreatic cancer liver metastasis through investigating the mechanism of formation and remodeling its microenvironment.
- Principal Investigator
  
  FUJITA Hayato
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidation of selection mechanism of disseminated cancer cells in metastatic organs
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
特異的膵星細胞の機能的分取による膵癌Desmoplasiaの解明
- Principal Investigator
  
  藤原謙次
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidation of the role of microRNA as a cancer treatment-resistant mechanism by autophagy
- Principal Investigator
  
  NAKATA Kohei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
The improvement of therapy-resistance with modified new virus and application to the treatment in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  EGAMI Takuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Application of GLP-1 on the treatment of pancreatic cancer
- Principal Investigator
  
  OHTSUKA Takao
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Identifying the leading cell for the invasion of pancreatic cancer
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Identification of the key stromal cell responsible for desmoplasia of pancreatic cancer, elucidation of the origin of it, and regulation of its function
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Functional analysis and regulation of microvesicles that affect tumor-stromal interaction in pancreatic cancer.
- Principal Investigator
  
  SHIMIZU Yukiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Establishment of a novel therapeutic strategy for pancreatic cancer phenotyping and regulating the pancreatic stellate cells in the tumor microenvironment
- Principal Investigator
  
  UEDA Junji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saga University
  Kyushu University
Establishment of therapy for individual based on diagnostic imaging by artificial virus
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Development of new therapeutic artificial virus with the ability of escape from endocytosisPrincipal Investigator
- Principal Investigator
  
  EGAMI Takuya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
The impact and clinical significance of mesenchymal stem cell in the process of metastasis in pancreatic cancer.
- Principal Investigator
  
  UEDA Junji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Breakthrough in the mechanism of adenoviral gene delivery and new developments to apply the achievement in a clinical settingPrincipal Investigator
- Principal Investigator
  
  EGAMI Takuya
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
- Journal Title
  
  Anticancer Research
  
  Volume: 31(4) Pages: 1279-1288
- Data Source
  KAKENHI-PROJECT-23791543
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer Sci.
  
  Volume: 102 Pages: 484-491
- NAID
  10029290639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791543
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer Sci. 102
  
  Pages: 484-491
- NAID
  10029290639
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells.2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
- Journal Title
  
  Anticancer Res.
  
  Volume: 31 Pages: 1279-1288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791543
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer science
  
  Volume: 102(2) Pages: 484-491
- NAID
  10029290639
- Data Source
  KAKENHI-PROJECT-23791543
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
- Journal Title
  
  Cancer science
  
  Volume: 102(2) Pages: 484-491
- NAID
  10029290639
- Data Source
  KAKENHI-PROJECT-23659655
[Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011
- Author(s)
  Yasui T, Egami T, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 484-491
- NAID
  10029290639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011
- Author(s)
  Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
- Journal Title
  
  Anticancer Research
  
  Volume: 31(4) Pages: 1279-1288
- Data Source
  KAKENHI-PROJECT-23659655
[Journal Article] Combination with low-dose gemcitabine andhTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer2010
- Author(s)
  Onimaru M, Ohuchida K, Nagai E,Mizumoto K, Egami T, Tanaka M
- Journal Title
  
  Cancer Lett
  
  Volume: 294(2) Pages: 178-86
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.2010
- Author(s)
  Onimaru M, Ohuchida K, Egami T, Mizumoto K, Nagai E, Cui L, Toma H, Matsumoto K, Hashizume M, Tanaka M,
- Journal Title
  
  Cancer Gene Ther. 17
  
  Pages: 541-549
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer.2010
- Author(s)
  Onimaru M, Egami T, et.al.
- Journal Title
  
  Cancer gene therapy
  
  Volume: 17 Pages: 541-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells2010
- Author(s)
  Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 17(8) Pages: 541-9
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer.2010
- Author(s)
  Manabu Onimaru, Kenoki Ohuchida, Eishi Nagai, Kazuhiro Mizumoto, Takuya Egami, Lin Cui, Norihiro Sato, Junji Uchino, Koichi Takayama, Makoto Hashizume, Masao Tanaka
- Journal Title
  
  Cancer Lett 294
  
  Pages: 178-186
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.2010
- Author(s)
  Onimaru M, Egami T, et at
- Journal Title
  
  Cancer Letter
  
  Volume: 294 Pages: 178-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer.2009
- Author(s)
  Takuya Egami, Kenoki Ohuchida, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Shoko Nishio, Eishi Nagai, Kunio Matsumoto, Toshikazu Nakamura, Masao Tanaka
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 722-729
- NAID
  10025144686
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy.2009
- Author(s)
  Takuya Egami, Kenoki Ohuchida, Takaharu Yasui, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Norihiro Sato, Kunio Matsumoto, Masao Tanaka
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 1902-1907
- Data Source
  KAKENHI-PROJECT-21791298
[Journal Article] Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells.
- Author(s)
  Takaharu Yasui, Kenoki Ohuchida, Ming Zhao, Lin Cui, Manabu Onimaru, Takuya Egami, Hayato Fujita, Takao Ohtsuka, Kazuhiro Mizumoto, Kunio Matsumoto, Masao Tanaka.
- Journal Title
  
  Anticancer research. in press
- Data Source
  KAKENHI-PROJECT-21791298
[Presentation] 放射線耐性膵癌細胞株におけるアデノウイルス遺伝子導入効率の検討2009
- Author(s)
  江上拓哉, 他
- Organizer
  日本膵臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21791298
[Presentation] 抗癌剤併用によるアデノウイルスベクターの遺伝子発現促進作用2009
- Author(s)
  江上拓哉, 他
- Organizer
  日本外科学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21791298

1. OHUCHIDA Kenoki (20452708)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
2. TANAKA Masao (30163570)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
3. MIYASAKA Yoshihiro (40507795)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. MAEYAMA Ryo (10611668)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. NAGAI Eishi (30264021)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
6. TOMINAGA Yohei (90304823)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. MIZUMOTO Kazuhiro (90253418)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
8. OHTSUKA Takao (20372766)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. NAKATA Kohei (30419569)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. 真鍋達也 (60546464)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. UEDA Junji (90529801)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. ONIMARU Manabu (80529876)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
13. 坂井寛 (80611665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. TOMA Hiroki (80437780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
15. MORIYAMA Taiki (70586859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. SHIRAHANE Kengo (10529803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. FUJITA Hayato (40611281)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 池永直樹 (90759755)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. TAKAHATA Shunichi (50437779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIMIZU Yukiko (10404021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MIYOSHI Kei (70755272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 村田正治 (30304744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 藤原謙次 (10727184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 寅田信博 (00398075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中山功一 (50420609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 進藤幸治 (00788432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 井上重隆 (00529802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 堀岡宏平 (10783699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 久保真 (60403961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 中山宏道 (80866773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Egami Takuya 江上 拓哉

EGAMI Takuya 江上 拓哉

Research Projects

Research Products

Co-Researchers

膵星細胞抑制薬とナノ粒子の組み合わせにより間質障壁を打破する新規膵癌治療薬の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵星細胞活性化遺伝子に着目した小胞体由来のオートファゴソーム膜起源の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NGS解析による膵癌微小環境とゲノム不均一性の解明とその治療への応用Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

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Research Institution

Principal Investigator

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Principal Investigator

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Research Institution

The role of autophagy in perineural infiltration of pancreatic cancerPrincipal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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The improvement of therapy-resistance with modified new virus and application to the treatment in pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Egami Takuya 江上拓哉

EGAMI Takuya 江上拓哉