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Egami Takuya  江上 拓哉

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EGAMI Takuya  江上 拓哉

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Researcher Number 40507787
Affiliation (Current) 2020: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help 2014 – 2020: 九州大学, 医学研究院, 共同研究員
2013 – 2016: 九州大学, 医学(系)研究科(研究院), 共同研究員
2012: 九州大学, 医学(系)研究科(研究院), 研究員
2011 – 2012: 九州大学, 医学研究院, 共同研究員
2011: 九州大学, 医学(系)研究科(研究院), 共同研究員
2009 – 2011: Kyushu University, 大学院・医学研究院, 共同研究員
2010: Kyushu University, 医学研究院
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Digestive surgery / Tumor biology and related fields / Basic Section 55020:Digestive surgery-related / Gastroenterology
Keywords
Principal Investigator
膵癌 / オートファジー / 膵臓外科学 / ウイルス治療 / エンドサイトーシス / アデノウイルス / 薬剤内包型人工ウイルス / Drug Delibery System / 治療耐性 / ウイルス … More / レンチウイルス / calpeptin / ramininα4 / MAL2遺伝子 / Nodal / HDAC1 / Sainomycin / Pirfenidone / S100A4 / ポックスウイルス / 神経浸潤 / 神経細胞 / ナノ粒子 / 膵星細胞 / 薬物送達システム … More
Except Principal Investigator
膵癌 / 膵星細胞 / 癌間質相互作用 / 肝転移 / 微小環境 / オルガノイド / 間葉系幹細胞 / オートファジー / 膵臓癌 / 癌微小環境 / 膵癌微小環境 / 膵臓外科学 / EMT / miRNA / Redox / 間様系幹細胞 / microRNA / IPMN / drug delivery system / 人工ウイルス / 浸潤 / 上皮間葉移行 / 細胞外基質 / リーディングセル / コラーゲン / 上皮間葉転換 / desmoplasia / CD51 / perivascular cell / ミクロベシクル / マイクロベシクル / ギャップジャンクション / CD271 / CD146 / podoplanin / 線維増生 / インクレチン / GLP-1 / Pancreatic cancer / PSCs / Leading cell / ECM remodeling / Cancer micro environment / Normalization / 細胞外マトリックス / leading cell / 基質リモデリング / 間質リモデリング / 線維芽細胞 / CD110 / トロンボポエチン(TPO) / ERK / MYC / 癌幹細胞 / トロンボポエチン / DNAマイクロアレイ / NPAS1 / マイクロRNA / エクソソーム / PSC / phenotype switching / 3Dバイオプリンター / 癌関連線維芽細胞 / 3Dバイオプリンター / 基質リモデリング制御 / ゲノム不均一性 / 次世代シークエンサー / リキッドバイオプシー / NGS解析 / 遺伝子変異 / シングルセル解析 / heterogeneity / 次世代シーケンサー / 遺伝子変異解析 / KPCマウス / 隔離膜 / 小胞体 Less
  • Research Projects

    (23 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (31 People)
  •  膵星細胞抑制薬とナノ粒子の組み合わせにより間質障壁を打破する新規膵癌治療薬の開発Principal InvestigatorOngoing

    • Principal Investigator
      江上 拓哉
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  膵星細胞活性化遺伝子に着目した小胞体由来のオートファゴソーム膜起源の解明Ongoing

    • Principal Investigator
      坂井 寛
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  NGS解析による膵癌微小環境とゲノム不均一性の解明とその治療への応用Ongoing

    • Principal Investigator
      進藤 幸治
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  Elucidating the mechanisms of pre-metastatic niche formation by pancreatic cancer exosomes

    • Principal Investigator
      MIYOSHI Kei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Control of microenvironment involved in pancreatic cancer progression and defense by phenotype switching

    • Principal Investigator
      OHUCHIDA Kenoki
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      Kyushu University
  •  Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter

    • Principal Investigator
      NAKAMURA Masafumi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      Kyushu University
  •  The role of autophagy in perineural infiltration of pancreatic cancerPrincipal Investigator

    • Principal Investigator
      EGAMI Takuya
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Elucidation of leading cell and cancer microenvironment normalization of pancreatic cancer

    • Principal Investigator
      OHUCHIDA Kenoki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Management of pancreatic cancer liver metastasis through investigating the mechanism of formation and remodeling its microenvironment.

    • Principal Investigator
      FUJITA Hayato
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Elucidation of selection mechanism of disseminated cancer cells in metastatic organs

    • Principal Investigator
      ONIMARU Manabu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  特異的膵星細胞の機能的分取による膵癌Desmoplasiaの解明

    • Principal Investigator
      藤原 謙次
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Elucidation of the role of microRNA as a cancer treatment-resistant mechanism by autophagy

    • Principal Investigator
      NAKATA Kohei
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  The improvement of therapy-resistance with modified new virus and application to the treatment in pancreatic cancerPrincipal Investigator

    • Principal Investigator
      EGAMI Takuya
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Application of GLP-1 on the treatment of pancreatic cancer

    • Principal Investigator
      OHTSUKA Takao
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Identifying the leading cell for the invasion of pancreatic cancer

    • Principal Investigator
      TANAKA Masao
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Identification of the key stromal cell responsible for desmoplasia of pancreatic cancer, elucidation of the origin of it, and regulation of its function

    • Principal Investigator
      MIZUMOTO Kazuhiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Functional analysis and regulation of microvesicles that affect tumor-stromal interaction in pancreatic cancer.

    • Principal Investigator
      SHIMIZU Yukiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kyushu University
  •  Establishment of a novel therapeutic strategy for pancreatic cancer phenotyping and regulating the pancreatic stellate cells in the tumor microenvironment

    • Principal Investigator
      UEDA Junji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Saga University
      Kyushu University
  •  Establishment of therapy for individual based on diagnostic imaging by artificial virus

    • Principal Investigator
      TANAKA Masao
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Development of new therapeutic artificial virus with the ability of escape from endocytosisPrincipal Investigator

    • Principal Investigator
      EGAMI Takuya
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer

    • Principal Investigator
      NAGAI Eishi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  The impact and clinical significance of mesenchymal stem cell in the process of metastasis in pancreatic cancer.

    • Principal Investigator
      UEDA Junji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Breakthrough in the mechanism of adenoviral gene delivery and new developments to apply the achievement in a clinical settingPrincipal Investigator

    • Principal Investigator
      EGAMI Takuya
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University

All 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
    • Journal Title

      Anticancer Research

      Volume: 31(4) Pages: 1279-1288

    • Data Source
      KAKENHI-PROJECT-23791543
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 484-491

    • NAID

      10029290639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791543
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
    • Journal Title

      Cancer Sci. 102

      Pages: 484-491

    • NAID

      10029290639

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells.2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
    • Journal Title

      Anticancer Res.

      Volume: 31 Pages: 1279-1288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791543
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
    • Journal Title

      Cancer science

      Volume: 102(2) Pages: 484-491

    • NAID

      10029290639

    • Data Source
      KAKENHI-PROJECT-23791543
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
    • Journal Title

      Cancer science

      Volume: 102(2) Pages: 484-491

    • NAID

      10029290639

    • Data Source
      KAKENHI-PROJECT-23659655
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011

    • Author(s)
      Yasui T, Egami T, et al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 484-491

    • NAID

      10029290639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
    • Journal Title

      Anticancer Research

      Volume: 31(4) Pages: 1279-1288

    • Data Source
      KAKENHI-PROJECT-23659655
  • [Journal Article] Combination with low-dose gemcitabine andhTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer2010

    • Author(s)
      Onimaru M, Ohuchida K, Nagai E,Mizumoto K, Egami T, Tanaka M
    • Journal Title

      Cancer Lett

      Volume: 294(2) Pages: 178-86

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.2010

    • Author(s)
      Onimaru M, Ohuchida K, Egami T, Mizumoto K, Nagai E, Cui L, Toma H, Matsumoto K, Hashizume M, Tanaka M,
    • Journal Title

      Cancer Gene Ther. 17

      Pages: 541-549

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer.2010

    • Author(s)
      Onimaru M, Egami T, et.al.
    • Journal Title

      Cancer gene therapy

      Volume: 17 Pages: 541-549

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells2010

    • Author(s)
      Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
    • Journal Title

      Cancer Gene Ther

      Volume: 17(8) Pages: 541-9

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer.2010

    • Author(s)
      Manabu Onimaru, Kenoki Ohuchida, Eishi Nagai, Kazuhiro Mizumoto, Takuya Egami, Lin Cui, Norihiro Sato, Junji Uchino, Koichi Takayama, Makoto Hashizume, Masao Tanaka
    • Journal Title

      Cancer Lett 294

      Pages: 178-186

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.2010

    • Author(s)
      Onimaru M, Egami T, et at
    • Journal Title

      Cancer Letter

      Volume: 294 Pages: 178-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer.2009

    • Author(s)
      Takuya Egami, Kenoki Ohuchida, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Shoko Nishio, Eishi Nagai, Kunio Matsumoto, Toshikazu Nakamura, Masao Tanaka
    • Journal Title

      Cancer Sci. 100

      Pages: 722-729

    • NAID

      10025144686

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy.2009

    • Author(s)
      Takuya Egami, Kenoki Ohuchida, Takaharu Yasui, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Norihiro Sato, Kunio Matsumoto, Masao Tanaka
    • Journal Title

      Cancer Sci. 100

      Pages: 1902-1907

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Journal Article] Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells.

    • Author(s)
      Takaharu Yasui, Kenoki Ohuchida, Ming Zhao, Lin Cui, Manabu Onimaru, Takuya Egami, Hayato Fujita, Takao Ohtsuka, Kazuhiro Mizumoto, Kunio Matsumoto, Masao Tanaka.
    • Journal Title

      Anticancer research. in press

    • Data Source
      KAKENHI-PROJECT-21791298
  • [Presentation] 放射線耐性膵癌細胞株におけるアデノウイルス遺伝子導入効率の検討2009

    • Author(s)
      江上拓哉, 他
    • Organizer
      日本膵臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21791298
  • [Presentation] 抗癌剤併用によるアデノウイルスベクターの遺伝子発現促進作用2009

    • Author(s)
      江上拓哉, 他
    • Organizer
      日本外科学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21791298
  • 1.  OHUCHIDA Kenoki (20452708)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 2 results
  • 2.  TANAKA Masao (30163570)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 4 results
  • 3.  MIYASAKA Yoshihiro (40507795)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  MAEYAMA Ryo (10611668)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  NAGAI Eishi (30264021)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 6.  TOMINAGA Yohei (90304823)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 7.  MIZUMOTO Kazuhiro (90253418)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 8.  OHTSUKA Takao (20372766)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  NAKATA Kohei (30419569)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 10.  真鍋 達也 (60546464)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 11.  UEDA Junji (90529801)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  ONIMARU Manabu (80529876)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 13.  坂井 寛 (80611665)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 14.  TOMA Hiroki (80437780)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 15.  MORIYAMA Taiki (70586859)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  SHIRAHANE Kengo (10529803)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  FUJITA Hayato (40611281)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  NAKAMURA Masafumi (30372741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  池永 直樹 (90759755)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  TAKAHATA Shunichi (50437779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SHIMIZU Yukiko (10404021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MIYOSHI Kei (70755272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  村田 正治 (30304744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  藤原 謙次 (10727184)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  寅田 信博 (00398075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  中山 功一 (50420609)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  進藤 幸治 (00788432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  井上 重隆 (00529802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  堀岡 宏平 (10783699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  久保 真 (60403961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  中山 宏道 (80866773)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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