Fujita Hayato 藤田逸人

… Alternative Names

FUJITA Hayato 藤田逸人

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Researcher Number	40611281
Affiliation (Current)	2023: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2023: 九州大学, 医学研究院, 共同研究員 2020 – 2021: 九州大学, 医学研究院, 共同研究員 2016 – 2019: 九州大学, 医学研究院, 助教 2013 – 2015: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学(系)研究科(研究院), 研究員 2011: 九州大学, 医学研究院, 共同研究員
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Tumor biology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 大腸癌 / 肝転移 / 膵癌 / 腫瘍微小環境 / 間葉系幹細胞 / シングルセル遺伝子発現解析 / 肥満 / 治療抵抗性 / シングルセル解析 / 大腸癌肝転移オルガノイド … More / 単細胞解析 / scRNA-seq / オルガノイド / 癌間質相互作用 / 化学療法抵抗性 / 蛍光分析 / 抗癌剤耐性 / exosome / 腹膜播種 / 線維芽細胞 / 間質リモデリング / 線維増生 / desmoplasia … More Except Principal Investigator 膵癌 / 膵星細胞 / オルガノイド / 微小環境 / heterogeneity / 腫瘍微小環境 / 癌微小環境 / 肝転移 / シングルセル解析 / 胃癌 / 癌関連線維芽細胞 / クラスター浸潤 / 膵癌自然発生マウス / 大腸癌 / 膵臓癌 / 空間的トランスクリプトーム解析 / 癌関連線維芽細胞 (CAF) / 腫瘍微小環境 (TME) / CAF / 免疫微小環境 / B細胞 / 術前化学療法 (NAC) / 化学療法 / scRNA-seq / 化合物スクリーニング / PDXマウス / オートファジー / 微小転移 / 4色発現マウス / 不均一性(heterogeneity) / 患者腫瘍組織移植モデル / 患者腫瘍組織移植モデル (PDXモデル) / 不均一性 (heterogeneity) / 腫瘍内不均一性 / 治療抵抗性 / PDX / シングルセル発現解析 / 食道癌 / 消化器癌 / 上皮間葉転換 / エピジェネティック / collective invasion / partial EMT / 癌間質相互作用 / 膵癌肝転移 / 癌関連線維芽細胞（CAFs） / HSC / CAFs / NETs / 膵オルガノイド / PSC / 癌関連マクロファージ / 基底膜 / MT1-MMP / MMP2 / 基底膜破壊 / リーディングセル / 基質リモデリング / 微小環境基質改変 / leading cells / 膵癌微小環境 / phenotype switching / メタボロームマッピング / 腫瘍間質 / Metabolome mapping / バイオマーカー探索 / 凍結組織アレイ / Energy Charge / MALDI-MSI / タンパク解析 / DNA/RNA解析 / 門脈系血液中マーカー解析 / タンパク / RNA / 大腸癌肝転移 / exosome / 肝内血管内皮細胞 / leading cell / 血管内皮細胞 / 播種 / 繊維芽細胞 / Endo180 / 転移 / リモデリング / 腹膜播種 / 湿潤・転移 / 腹膜中皮細胞 / 間質細胞 Less

核内transcriptomeから解明する肥満大腸がん患者のmetabolismPrincipal Investigator
- Principal Investigator
  
  藤田逸人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University
scRNA-seq解析による胃癌NAC後微小環境中B細胞subsetの変動解析
- Principal Investigator
  
  永井英司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
空間的トランスクリプトーム解析によるCAF誘導性大腸癌免疫リモデリング機構の解明
- Principal Investigator
  
  佐田政史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
大腸癌肝転移オルガノイドと単細胞解析を用いた微小環境改変に伴う治療抵抗機序の解明Principal Investigator
- Principal Investigator
  
  藤田逸人
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
KPC confettiマウスがもたらす膵癌微小環境制御の新たな理解
- Principal Investigator
  
  安井隆晴
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
PDX-3D法を用いた創薬ライブラリ構築と新規膵癌治療薬探索
- Principal Investigator
  
  水元一博
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  International University of Health and Welfare
  Kyushu University
Elucidation and control of the mechanism of cluster invasion by partialEMT using pancreatic cancer organoids
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Analysis of single-cell transcriptome with Drop-seq for heterogeneity in the tumor microenvironment derived from digestive cancers.
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Elucidation of the intratumor therapeutic resistance heterogeneity using single-cell transcriptome of the PDX libraries with pancreatic cancer.
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis of pancreatic cancer metastasis-promoting microenvironment induced by neutrophil extracellular traps
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Elucidation of microenvironment induction mechanism by exosome in liver metastasis and peritoneal dissemination of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  FUJITA Hayato
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
RNA / protein analysis in portal blood exosomes to detect a high risk group of colorectal cancer liver metastases
- Principal Investigator
  
  SADAKARI Yoshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Metabolome mapping analysis of tumor associated stroma in genetically engineered pancreatic cancer mouse model
- Principal Investigator
  
  TORATA Nobuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Control of microenvironment involved in pancreatic cancer progression and defense by phenotype switching
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
Elucidation of mechanism of PSC leading to pancreatic cancer cluster invasion and pancreatic cancer control by microenvironmental substrate remodeling
- Principal Investigator
  
  IKENAGA Naoki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
Elucidation of leading PSC induced basement membrane destruction mechanism and development of the regulating method by using pancreatic organoids
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Nobel role of liver endothelial cells in liver metastasis formation
- Principal Investigator
  
  MAEYAMA Ryo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Relationship between stromal cells and pancreatic cancer cells in metastasis and dissemination
- Principal Investigator
  
  MORIYAMA Taiki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Management of pancreatic cancer liver metastasis through investigating the mechanism of formation and remodeling its microenvironment.Principal Investigator
- Principal Investigator
  
  FUJITA Hayato
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
New development of pancreatic cancer stromal control based on the molecular analysisPrincipal Investigator
- Principal Investigator
  
  FUJITA Hayato
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
分子生物学的解析に基づく膵癌間質制御の新展開Principal Investigator
- Principal Investigator
  
  藤田逸人
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2019 2018 2016 2011

All Journal Article Presentation

[Journal Article] Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin‐treated rectal cancer: In situ visualization of platinum via synchrotron radiation X‐ray fluorescence spectrometry.2019
- Author(s)
  Ryo Koba Hayato Fujita Maiko Nishibori Kiyoshi Saeki Kinuko Nagayoshi Yoshihiko Sadakari Shuntaro Nagai Oki Sekizawa Kiyofumi Nitta Tatsuya Manabe Takashi Ueki Tatsuhiro Ishida Yoshinao Oda Masafumi Nakamura
- Journal Title
  
  International Journal of Cancer
  
  Volume: 146 Issue: 9 Pages: 2498-2509
- DOI
  10.1002/ijc.32592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10636, KAKENHI-PROJECT-17K10637, KAKENHI-PROJECT-18K16367
[Journal Article] Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL.2016
- Author(s)
  Chijiiwa Y, Moriyama T, Ohuchida K, Nabae T, Ohtsuka T, Miyasaka Y, Fujita H, Maeyama R, Manabe T, Abe A, Mizuuchi Y, Oda Y, Mizumoto K, Nakamura M
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 4 Pages: 1688-1700
- DOI
  10.3892/ijo.2016.3389
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10185, KAKENHI-PROJECT-15K10186, KAKENHI-PROJECT-26462062, KAKENHI-PROJECT-26462064, KAKENHI-PROJECT-25461024, KAKENHI-PROJECT-25462117, KAKENHI-PROJECT-26670607, KAKENHI-ORGANIZER-26108001, KAKENHI-PLANNED-26108010
[Journal Article] Suppression of CD51 in pancreatic stellate cells inhibits tumor growth by reducing stroma and altering tumor-stromal interaction in pancreatic cancer2016
- Author(s)
  Horioka K, Ohuchida K, Sada M, Zheng B, Moriyama T, Fujita H, Manabe T, Ohtsuka T, Shimamoto M, Miyazaki T, Mizumoto K, Oda Y, Nakamura M.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 4 Pages: 1499-1508
- DOI
  10.3892/ijo.2016.3374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10185, KAKENHI-PROJECT-15K10188, KAKENHI-PROJECT-26462063, KAKENHI-PROJECT-26462064, KAKENHI-PROJECT-15K19895, KAKENHI-PROJECT-15H04933, KAKENHI-PROJECT-25462116, KAKENHI-PROJECT-25462118, KAKENHI-PROJECT-26670607, KAKENHI-PROJECT-26861084, KAKENHI-PROJECT-26293305, KAKENHI-ORGANIZER-26108001, KAKENHI-PLANNED-26108010, KAKENHI-PROJECT-15K09046
[Journal Article] （The） Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model2016
- Author(s)
  Yoshida M, Miyasaka Y, Ohuchida Kenoki, Okumura T, Zheng B, Torata N, Fujita H, Nabae T, Manabe T, Shimamoto M, Ohtsuka T, Mizumoto K, Nakamura M
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 10 Pages: 1443-1452
- DOI
  10.1111/cas.13024
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26108001, KAKENHI-PLANNED-26108010, KAKENHI-PROJECT-15H04933, KAKENHI-PROJECT-26293305, KAKENHI-PROJECT-26462063, KAKENHI-PROJECT-16K10599, KAKENHI-PROJECT-16K10600
[Journal Article] 分子生物学的研究に基づく膵癌の診断と治療-臨床応用を目指して-2011
- Author(s)
  藤田逸人, 他
- Journal Title
  
  福岡医学雑誌
  
  Volume: 102 Pages: 203-214
- NAID
  40018954520
- Data Source
  KAKENHI-PROJECT-23890151
[Presentation] Stage IV大腸癌に対する外科的治療の役割2019
- Author(s)
  藤田逸人、木庭遼、永吉絹子、貞苅良彦、永井俊太郎、大内田研宙、大塚隆生、中村雅史
- Organizer
  第119回日本外科学会
- Data Source
  KAKENHI-PROJECT-17K10636
[Presentation] 腫瘍間質における直腸癌L-OHP抵抗性の誘導：放射光蛍光X線を用いた白金分布分析2019
- Author(s)
  木庭遼、藤田逸人、西堀麻衣子、永吉絹子、貞苅良彦、永井俊太郎、関澤央輝、新田清文、大内田研宙、大塚隆生、植木隆、石田竜弘、中村雅史
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10637
[Presentation] Oxaliplatin投与後の大腸癌組織における蛍光X線分析－組織内の白金分布と治療効果との関連性の検討－2019
- Author(s)
  木庭遼、藤田逸人、西堀麻衣子、永吉絹子、貞苅良彦、永井俊太郎、関澤央輝、新田清文、大内田研宙、大塚隆生、植木隆、石田竜弘、中村雅史
- Organizer
  日本分析化学会第79回分析化学討論会
- Data Source
  KAKENHI-PROJECT-17K10637
[Presentation] Oxaliplatin投与後の大腸癌組織における蛍光X線分析－組織内の白金分布と治療効果との関連性の検討－2019
- Author(s)
  木庭遼、藤田逸人、西堀麻衣子、永吉絹子、貞苅良彦、永井俊太郎、関澤央輝、新田清文、大内田研宙、大塚隆生、植木隆、石田竜弘、中村雅史
- Organizer
  日本分析化学会第79回分析化学討論会
- Data Source
  KAKENHI-PROJECT-17K10636
[Presentation] 腫瘍間質における直腸癌L-OHP抵抗性の誘導：放射光蛍光X線を用いた白金分布分析2019
- Author(s)
  木庭遼、藤田逸人、西堀麻衣子、永吉絹子、貞苅良彦、永井俊太郎、関澤央輝、新田清文、大内田研宙、大塚隆生、植木隆、石田竜弘、中村雅史
- Organizer
  第119回日本外科学会
- Data Source
  KAKENHI-PROJECT-17K10636
[Presentation] Stage IV大腸癌症例に対する外科的治療戦略2018
- Author(s)
  藤田逸人、永吉絹子、貞苅良彦、永井俊太郎、大内田研宙、大塚隆生、中村雅史
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10636
[Presentation] Oxaliplatin投与後の直腸癌組織における蛍光X線分析を用いた金属元素の分布測定2018
- Author(s)
  木庭遼、植木隆、西堀麻衣子、石田竜弘、永吉絹子、藤田逸人、永井俊太郎、大内田研宙、大塚隆生、中村雅史
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10636
[Presentation] 膵癌におけるCXCL1mRNA発現解析の意義2011
- Author(s)
  藤田逸人, 他
- Organizer
  第111回日本外科学会定期学術集会
- Place of Presentation
  東京都(紙上開催)
- Data Source
  KAKENHI-PROJECT-23890151

1. OHUCHIDA Kenoki (20452708)

# of Collaborated Projects: 11 results

# of Collaborated Products: 2 results
2. MORIYAMA Taiki (70586859)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. MAEYAMA Ryo (10611668)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TORATA Nobuhiro (00398075)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 永吉絹子 (90761015)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. 宮坂義浩 (40507795)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. IKENAGA Naoki (90759755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 水元一博 (90253418)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
9. 岩本千佳 (10752842)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. SADAKARI Yoshihiko (80784503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
11. NAGAI Eishi (30264021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 江上拓哉 (40507787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 坂井寛 (80611665)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 大塚隆生 (20372766)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 三好圭 (70755272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 仲田興平 (30419569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 田中雅夫 (30163570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 真鍋達也 (60546464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井上重隆 (00529802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 村田正治 (30304744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 安井隆晴 (60611283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 木庭遼 (10866776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 冨永洋平 (90304823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 水内祐介 (20849088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中山宏道 (80866773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 進藤幸治 (00788432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 佐田政史 (10783508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 甲斐昌也 (10755242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 藤田廣志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujita Hayato 藤田 逸人

FUJITA Hayato 藤田 逸人

Research Projects

Research Products

Co-Researchers

核内transcriptomeから解明する肥満大腸がん患者のmetabolismPrincipal Investigator

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Principal Investigator

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大腸癌肝転移オルガノイドと単細胞解析を用いた微小環境改変に伴う治療抵抗機序の解明Principal Investigator

Principal Investigator

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Principal Investigator

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Principal Investigator

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Elucidation of microenvironment induction mechanism by exosome in liver metastasis and peritoneal dissemination of colorectal cancerPrincipal Investigator

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Fujita Hayato 藤田逸人

FUJITA Hayato 藤田逸人