TOMA Hiroki 当間宏樹

… Alternative Names

当間宏樹トウマヒロキ

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Researcher Number	80437780
Affiliation (Current)	2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2025: 九州大学, 医学研究院, 共同研究員 2022 – 2023: 九州大学, 医学研究院, 共同研究員 2015 – 2018: 九州大学, 医学研究院, 共同研究員 2012 – 2015: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学研究院, 共同研究員 2011: 九州大学, 大学病院, 講師 2007 – 2010: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Digestive surgery / Tumor biology and related fields
Keywords	Principal Investigator 膵癌 / 樹状細胞 / miRNA / microRNA / エピジェネティック / 乳酸 / 腫瘍微小環境 / 腫瘍免疫療法 / Autophagy抑制 / 膵癌微小環境 … More / 膵癌間質 / 腫瘍免疫微小環境 / 腫瘍免疫 / CAF / Autophagy / 膵周囲脂肪組織 / S100A4 / リノレン酸 / 脂肪酸 / High fat diet / 活性化型膵星細胞 / 癌関連線維芽細胞 / 脂肪組織由来幹細胞 / エクソソーム / 癌間質相互作用 / マイクロダイセクション / Gemcitabine / 膵液 / 治療抵抗性 / 膵臓外科学 … More Except Principal Investigator 膵癌 / 膵星細胞 / 癌間質相互作用 / IPMN / 膵臓外科学 / 膵臓癌 / オートファジー / microRNA / mRNA / 基質リモデリング制御 / 膵癌微小環境 / 3Dバイオプリンター / 癌関連線維芽細胞 / 微小環境 / オルガノイド / ３Dバイオプリンター / オートファジー抑制剤 / 創薬 / 早期診断 / 膵前癌病変 / 膵液 / miRNA / エクソゾーム / バイオマーカー / biomarker / micro RNA / exosome / ADM / PDAC / CD51 / 細胞外基質 / 腫瘍血管 / 血管リモデリング / 周皮細胞 / 抗繊維化薬 / ナノカプセル / 化学療法抵抗性 / ドラッグデリバリーシステム(DDS) / 抗間質薬 / 膵癌間質細胞 / 癌微小環境 / セルソーテング / 上皮間葉移行(EMT) / セルソーティング / mRNA/microRNA / 癌間相互作用 / 間質細胞 / ニッチ / 間質幹細胞 / 治療抵抗性 / セルソート / 癌幹細胞 / S100A11 / S100P / H-tert / Muc family / twist / FFPEサンプル / hTERT / テロメラーゼ / 電気化学チップ / LM04 / S100 family Less

エピゲノム解析による樹状細胞のラクチル化が抗原提示機能に及ぼす影響の検討Principal Investigator
- Principal Investigator
  
  当間宏樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Autophagyに着目した、膵癌における免疫抑制微小環境の解明と新規治療開発Principal Investigator
- Principal Investigator
  
  当間宏樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
Development of biomarkers target on exosomes which derived from stromal cells in premalignant microenvironment.
- Principal Investigator
  
  MIYASAKA Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
New drug discovery screening targeting autophagy
- Principal Investigator
  
  NAKATA Kohei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Role of adipose tissue in pancreatic cancer local invasion as a component of tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Refractory cancer therapy development by cancer microenvironment elucidation and new drug delivery system based on autophagy
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Investigation of mechanisms about therapeutic resistance due to the difference of pancreatic stellate cell phenotypes and development of nano capsule including anti-stromal drugs
- Principal Investigator
  
  MAEYAMA Ryo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
A new strategy in the treatment of pancreatic cancer focused on the tumor vessel remodeling by pericytes
- Principal Investigator
  
  MANABE Tatsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
New development in the study of tumor-stromal interaction focused on extracellular miRNA via exosome.Principal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
General overview of research on diagnosis of pancreatic cancer using molecular makersinpancreaticjuiccandclinicalapPlicationofmolecularmakersondiagnosisofIPMNsubtype
- Principal Investigator
  
  MIZUMOTO Kazihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Identification of microRNA which is related to chemoresistance of pancreatic cancer, and intensification of the sensitivity by controlling the microRNA.Principal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
膵癌幹細胞の同定とニッチの機能解析〜膵癌の治療抵抗性を克服するために
- Principal Investigator
  
  水元一博
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Gene expressions in microdissected target cells as the diagnostic markers of pancreatic cancer and the prediction of treatment outcome using nano-technology
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers2013
- Author(s)
  Nagai E, Ohuchida K, Nakata K, Toma H, Tanaka M
- Journal Title
  
  Surgery
  
  Volume: 153(5) Pages: 732-8
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Feasibility of laparoscopic gastrectomy for advanced gastric cancer with positive peritoneal cytology2012
- Author(s)
  Yamanaka N, Nagai E, Ohuchida K, Ueda J, Toma H, Tanaka M
- Journal Title
  
  Surg Today
- NAID
  10031189764
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma2012
- Author(s)
  Nakata K, Nagai E, Ohuchida K, Ohtsuka T, Toma H, Tanaka M
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 59(118) Pages: 1855-8
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Single-incision laparoscopy -assisted surgery for bowel obstruction: report of three cases2011
- Author(s)
  Ohtsuka T, Nagai E, Toma H, Ohuchida K, Tanaka M
- Journal Title
  
  Surg Today
  
  Volume: 41(11) Pages: 1519-23
- NAID
  10030229390
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer2011
- Author(s)
  Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 18(7) Pages: 2057-65
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells2010
- Author(s)
  Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 17(8) Pages: 541-9
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] MircoRNA-2l modulates biological functions of pancreatic cacner cells including their proliferation, invasion and chemoresistance2009
- Author(s)
  Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sate N, Nabae T, Takahata S, Toma H, Nagai E and Tanaka M
- Journal Title
  
  Molecular cancer therapeutics
  
  Volume: 8 Pages: 1067-1074
- Data Source
  KAKENHI-PROJECT-21390380
[Presentation] 膵癌におけるCD133陽性細胞は、癌間質作用を介してより高い遊走・浸潤能を獲得する.2009
- Author(s)
  森山大樹, 大内田研宙, 水元一博, 崔林, 余俊, 江上拓哉, 藤田逸人, 佐藤典宏, 当間宏樹, 永井英司, 田中雅夫
- Organizer
  第109回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21390381

1. OHUCHIDA Kenoki (20452708)

# of Collaborated Projects: 13 results

# of Collaborated Products: 8 results
2. MIZUMOTO Kazuhiro (90253418)

# of Collaborated Projects: 8 results

# of Collaborated Products: 3 results
3. TOMINAGA Yohei (90304823)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TANAKA Masao (30163570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
5. EISHI Nagai (30264021)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. UEDA Junji (90529801)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. MIYASAKA Yoshihiro (40507795)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. MAEYAMA Ryo (10611668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. SATO Norihro (20423527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. EGAMI Takuya (40507787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. NAKATA Kohei (30419569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 白羽根健吾 (10529803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 森山大樹 (70586859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. TKENAKA Shigeori (60188208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ONA Toshihiro (10346835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MANABE Tatsuya (60546464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高畑俊一 (50437779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中山功一 (50420609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐田政史 (10783508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 阿部俊也 (20722028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 堀岡宏平 (10783699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 新川智彦 (40982319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 安井隆晴 (60611283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOMA Hiroki 当間 宏樹

当間 宏樹 トウマ ヒロキ

Research Projects

Research Products

Co-Researchers

エピゲノム解析による樹状細胞のラクチル化が抗原提示機能に及ぼす影響の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Autophagyに着目した、膵癌における免疫抑制微小環境の解明と新規治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of adipose tissue in pancreatic cancer local invasion as a component of tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New development in the study of tumor-stromal interaction focused on extracellular miRNA via exosome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of microRNA which is related to chemoresistance of pancreatic cancer, and intensification of the sensitivity by controlling the microRNA.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TOMA Hiroki 当間宏樹

当間宏樹トウマヒロキ