TOMA Hiroki 当間宏樹

Researcher Number	80437780
Affiliation (Current)	2021: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2015 – 2018: 九州大学, 医学研究院, 共同研究員 2012 – 2015: 九州大学, 医学(系)研究科(研究院), 共同研究員 2012: 九州大学, 医学研究院, 共同研究員 2011: 九州大学, 大学病院, 講師 2007 – 2010: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery Except Principal Investigator Digestive surgery / Tumor biology and related fields
Keywords	Principal Investigator 膵癌 / microRNA / miRNA / 膵臓外科学 / 治療抵抗性 / 膵液 / Gemcitabine / マイクロダイセクション / 癌間質相互作用 / エクソソーム … More Except Principal Investigator 膵癌 / 癌間質相互作用 / 膵星細胞 / 膵臓外科学 / IPMN / mRNA / microRNA / オートファジー / 膵臓癌 / S100 family / LM04 / 電気化学チップ / テロメラーゼ / hTERT / FFPEサンプル / twist / Muc family / H-tert / S100P / S100A11 / 癌幹細胞 / セルソート / 治療抵抗性 / 間質幹細胞 / ニッチ / 間質細胞 / 癌間相互作用 / mRNA/microRNA / セルソーティング / 上皮間葉移行(EMT) / セルソーテング / 癌微小環境 / 膵癌間質細胞 / 抗間質薬 / ドラッグデリバリーシステム(DDS) / 化学療法抵抗性 / ナノカプセル / 抗繊維化薬 / 周皮細胞 / 血管リモデリング / 腫瘍血管 / 細胞外基質 / CD51 / PDAC / ADM / exosome / micro RNA / biomarker / バイオマーカー / エクソゾーム / miRNA / 膵液 / 膵前癌病変 / 早期診断 / 創薬 / オートファジー抑制剤 / ３Dバイオプリンター / オルガノイド / 微小環境 / 癌関連線維芽細胞 / 3Dバイオプリンター / 膵癌微小環境 / 基質リモデリング制御 Less

Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Kyushu University
Development of biomarkers target on exosomes which derived from stromal cells in premalignant microenvironment.
- Principal Investigator
  
  MIYASAKA Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
New drug discovery screening targeting autophagy
- Principal Investigator
  
  NAKATA Kohei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Role of adipose tissue in pancreatic cancer local invasion as a component of tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Refractory cancer therapy development by cancer microenvironment elucidation and new drug delivery system based on autophagy
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Investigation of mechanisms about therapeutic resistance due to the difference of pancreatic stellate cell phenotypes and development of nano capsule including anti-stromal drugs
- Principal Investigator
  
  MAEYAMA Ryo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
A new strategy in the treatment of pancreatic cancer focused on the tumor vessel remodeling by pericytes
- Principal Investigator
  
  MANABE Tatsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
New development in the study of tumor-stromal interaction focused on extracellular miRNA via exosome.Principal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer
- Principal Investigator
  
  NAGAI Eishi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
General overview of research on diagnosis of pancreatic cancer using molecular makersinpancreaticjuiccandclinicalapPlicationofmolecularmakersondiagnosisofIPMNsubtype
- Principal Investigator
  
  MIZUMOTO Kazihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy
- Principal Investigator
  
  TANAKA Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Identification of microRNA which is related to chemoresistance of pancreatic cancer, and intensification of the sensitivity by controlling the microRNA.Principal Investigator
- Principal Investigator
  
  TOMA Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
膵癌幹細胞の同定とニッチの機能解析〜膵癌の治療抵抗性を克服するために
- Principal Investigator
  
  水元一博
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Gene expressions in microdissected target cells as the diagnostic markers of pancreatic cancer and the prediction of treatment outcome using nano-technology
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers2013
- Author(s)
  Nagai E, Ohuchida K, Nakata K, Toma H, Tanaka M
- Journal Title
  
  Surgery
  
  Volume: 153(5) Pages: 732-8
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Feasibility of laparoscopic gastrectomy for advanced gastric cancer with positive peritoneal cytology2012
- Author(s)
  Yamanaka N, Nagai E, Ohuchida K, Ueda J, Toma H, Tanaka M
- Journal Title
  
  Surg Today
- NAID
  10031189764
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma2012
- Author(s)
  Nakata K, Nagai E, Ohuchida K, Ohtsuka T, Toma H, Tanaka M
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 59(118) Pages: 1855-8
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Single-incision laparoscopy -assisted surgery for bowel obstruction: report of three cases2011
- Author(s)
  Ohtsuka T, Nagai E, Toma H, Ohuchida K, Tanaka M
- Journal Title
  
  Surg Today
  
  Volume: 41(11) Pages: 1519-23
- NAID
  10030229390
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer2011
- Author(s)
  Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 18(7) Pages: 2057-65
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells2010
- Author(s)
  Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 17(8) Pages: 541-9
- Data Source
  KAKENHI-PROJECT-22390258
[Journal Article] MircoRNA-2l modulates biological functions of pancreatic cacner cells including their proliferation, invasion and chemoresistance2009
- Author(s)
  Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sate N, Nabae T, Takahata S, Toma H, Nagai E and Tanaka M
- Journal Title
  
  Molecular cancer therapeutics
  
  Volume: 8 Pages: 1067-1074
- Data Source
  KAKENHI-PROJECT-21390380
[Presentation] 膵癌におけるCD133陽性細胞は、癌間質作用を介してより高い遊走・浸潤能を獲得する.2009
- Author(s)
  森山大樹, 大内田研宙, 水元一博, 崔林, 余俊, 江上拓哉, 藤田逸人, 佐藤典宏, 当間宏樹, 永井英司, 田中雅夫
- Organizer
  第109回日本外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21390381

1. OHUCHIDA Kenoki (20452708)

# of Collaborated Projects: 13 results

# of Collaborated Products: 8 results
2. MIZUMOTO Kazuhiro (90253418)

# of Collaborated Projects: 8 results

# of Collaborated Products: 3 results
3. TOMINAGA Yohei (90304823)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. TANAKA Masao (30163570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
5. EISHI Nagai (30264021)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. UEDA Junji (90529801)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. MIYASAKA Yoshihiro (40507795)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. MAEYAMA Ryo (10611668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. SATO Norihro (20423527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. EGAMI Takuya (40507787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. NAKATA Kohei (30419569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 白羽根健吾 (10529803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TKENAKA Shigeori (60188208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONA Toshihiro (10346835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MANABE Tatsuya (60546464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高畑俊一 (50437779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中山功一 (50420609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 森山大樹 (70586859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOMA Hiroki 当間 宏樹

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Role of adipose tissue in pancreatic cancer local invasion as a component of tumor microenvironmentPrincipal Investigator

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New development in the study of tumor-stromal interaction focused on extracellular miRNA via exosome.Principal Investigator

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Identification of microRNA which is related to chemoresistance of pancreatic cancer, and intensification of the sensitivity by controlling the microRNA.Principal Investigator

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[Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers2013

Author(s)

Journal Title

TOMA Hiroki 当間宏樹