Aoki Tomohiro 青木友浩

… Alternative Names

AOKI TOMOHIRO 青木友浩

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Researcher Number	40633144
Other IDs	https://orcid.org/0000-0002-1578-1394
Affiliation (Current)	2024: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 東京慈恵会医科大学, 医学部, 教授 2017 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2017: 京都大学, 大学院医学研究科, 研究員 2016: 京都大学, 医学研究科, 特定准教授 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授
Review Section/Research Field	Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related / Cerebral neurosurgery Except Principal Investigator Basic Section 56010:Neurosurgery-related / Medium-sized Section 90:Biomedical engineering and related fields / Complex Systems Disease Theory / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Neurosurgery
Keywords	Principal Investigator マクロファージ / 脳動脈瘤 / 炎症反応 / 慢性炎症 / クモ膜下出血 / 炎症 / くも膜下出血 / 薬物治療 / 創薬 / 好中球 … More / Ｔ細胞 / T細胞 / 遊走因子 / 細胞分裂 / 低ずり応力 / ずり応力 / 乱流 / MCP-1 / 内皮細胞 / 血流 / プロスタグランディン / 平滑筋細胞 / 脂肪蓄積 / FP / プロスタグランジン / TNF-alpha / 脂質 / 細胞外基質 … More Except Principal Investigator 脳動脈瘤 / 動物モデル / くも膜下出血 / 炎症 / cerebral aneurysm / バイオインフォマティクス / う蝕原性細菌 / 未破裂脳動脈瘤 / intestinal flora / oral flora / intracranial aneurysms / subarachnoid hemorrhage / 遺伝子 / aneurysm / もやもや病 / マクロファージ / PKD / 超音波顕微鏡 / リモデリング / 微視的力学場 / 組織反応 / 血管リモデリング / 血管組織 / 力学場 / 動脈瘤 / 血管 / preventive medicine / microorganism / 腸ー脳相関 / bioproduct / 口腔細菌 / 遺伝子解析 / バイオプロダクト / 体内細菌叢 / bioinformatics / micorbiota / intestinal bacteria / oral bacteria / stroke / vessel wall injury / 16sRNA / bioproducts / 細菌性心内膜炎 / Streptcoccus mutans / 発生 / 破裂 / 腸内細菌 / 口腔内細菌 / 数値流体力学 / 数理モデリング / 血栓形成シミュレータ / ステント留置 / 留置シミュレータ / CFD解析 / 血栓化ダイナミクス / 血栓形成の数理モデル / 走化性方程式系 / 数理モデル / 血栓過程 / ステント留置術 / 数値流体力学解析 / Navier-Stokes方程式 / control / international / bacterial flora / intracranial aneurysm / 口腔内細菌叢 / 腸ー能相関 / 代謝産物 / 国際比較 / 腸内細菌叢 / data trnasfer / bioinfromatics / incidence difference / シーケンス / genetics / RNF213遺伝子 / レアバリアント / RN213 / 感受性遺伝子 / RNF213 / 遺伝解析 / インドシアニングリーン / 酸化鉄 / 慢性炎症 / indocyanine green / fluorescent imaging / nanoparticles / iron oxide / inflammation / macrophage / パスウェイ異常 / 次世代シークエンサー / マイクロアレイ / 遺伝子発現解析 / MR / MRイメージング / プロスタグランジン / 脳神経疾患 / イメージング / medical treatment / MR imaging / animal model Less

血管組織内微視的力学場の定量による瘤発生機構解明と力学環境操作による病理応答制御
- Principal Investigator
  
  中村匡徳
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Nagoya Institute of Technology
PKD遺伝子異常に伴う脳動脈瘤発生の病態解明
- Principal Investigator
  
  野崎和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
Identification of therapeutic targets to prevent rupture of intracranial aneurysm.Principal Investigator
- Principal Investigator
  
  AOKI TOMOHIRO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  National Cardiovascular Center Research Institute
Why subarachnoid hemorrhage occure more frequentry in Japanese than other population?
- Principal Investigator
  
  Morita Akio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nippon Medical School
Elucidation of the effect of Microorganism of the body on the origin and rupture of the intracranial aneurysms and development of preventive measure of the subarachnoid hemorrhage
- Principal Investigator
  
  Morita Akio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nippon Medical School
Pathological and molecular analysis of cerebral aneurysms using live imaging
- Principal Investigator
  
  Kazuhiko Nozaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the onset mechanism of moyamoya disease by identifying pathway abnormalities
- Principal Investigator
  
  Araki Yoshio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Nagoya University
Activatable Fluorescence Imaging of Macrophages in Cerebral Aneurysms Using Iron Oxide Nanoparticles Conjugated With Indocyanine Green
- Principal Investigator
  
  Ishii Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyoto University
Analysis of rare variants in RNF213 in patients of cerebral aneurysm
- Principal Investigator
  
  Kasuya Hidetoshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Tokyo Women's Medical University
Development and clinical application of a mathematical model to explain thrombogenic dynamics during the healing process of cerebral aneurysms
- Principal Investigator
  
  Sugiyama Yoshie
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Osaka University
Contribution of T cell function to the pathogenesis of intracranial aneurysms.Principal Investigator
- Principal Investigator
  
  AOKI TOMOHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  National Cardiovascular Center Research Institute
  Kyoto University
Development of cell and molecular imaging and possible medical treatment for cerebral aneurysms
- Principal Investigator
  
  Nozaki Kazuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Shiga University of Medical Science
The mechanisms underlying the enlargement of intracranial aneurysm focused on hemodynamic stress loadingPrincipal Investigator
- Principal Investigator
  
  TOMOHIRO AOKI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University
Clarification of mechanisms underlying the enlargement of intracranial aneurysms focused on drop-out of medial smooth muscle cells.Principal Investigator
- Principal Investigator
  
  AOKI TOMOHIRO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 最新臨床脳卒中学（第2版）下2022
- Author(s)
  宮田悠、青木友浩、野崎和彦
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-19K09479
[Book] 脳神経外科ジャーナル2020
- Author(s)
  野崎和彦、宮田悠、青木友浩
- Total Pages
  46
- Publisher
  三輪書店
- Data Source
  KAKENHI-PROJECT-20K09381
[Book] 疾患に挑むメカノバイオロジー2020
- Author(s)
  青木友浩、清水寛平、山本希美子
- Total Pages
  220
- Publisher
  羊土社
- ISBN
  9784758103862
- Data Source
  KAKENHI-PROJECT-20K09381
[Book] 脳動脈瘤の発生と破裂の分子生物学的メカニズム2017
- Author(s)
  青木　友浩、野﨑　和彦
- Total Pages
  7
- Publisher
  三輪書店
- Data Source
  KAKENHI-PROJECT-15H04949
[Book] プライム脳神経外科2017
- Author(s)
  野崎和彦、青木友浩
- Total Pages
  7
- Publisher
  三輪書店
- ISBN
  9784895905879
- Data Source
  KAKENHI-PROJECT-16K10719
[Journal Article] Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm2023
- Author(s)
  Ono Isao、Kayahara Tomomichi、Kawashima Akitsugu、Okada Akihiro、Miyamoto Susumu、Kataoka Hiroharu、Kurita Hiroki、Ishii Akira、Aoki Tomohiro
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 5545-5545
- DOI
  10.1038/s41598-023-32001-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-20K09381
[Journal Article] 脳動脈瘤発症増大の分子機序2022
- Author(s)
  青木友浩、岡田明大、小野功朗、栢原智道
- Journal Title
  
  最新臨床脳卒中学第２版下
  
  Volume: 80 Pages: 693-698
- Data Source
  KAKENHI-PROJECT-20K09381
[Journal Article] 脳動脈瘤病態の分子機序に基づく新規の診断治療の可能性2022
- Author(s)
  青木友浩、小野功朗、栢原智道、岡田明大
- Journal Title
  
  最新臨床脳卒中学第２版上
  
  Volume: 80 Pages: 170-176
- Data Source
  KAKENHI-PROJECT-20K09381
[Journal Article] Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase2022
- Author(s)
  Okada Akihiro、Koseki Hirokazu、Ono Isao、Kayahara Tomomichi、Kurita Hiroki、Miyamoto Susumu、Kataoka Hiroharu、Aoki Tomohiro
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 31 Issue: 12 Pages: 106848-106848
- DOI
  10.1016/j.jstrokecerebrovasdis.2022.106848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-20K09381
[Journal Article] Endothelial cell malfunction in unruptured intracranial aneurysm lesions revealed using a 3D-casted mold2022
- Author(s)
  Ono Isao、Abekura Yu、Kawashima Akitsugu、Oka Mieko、Okada Akihiro、Hara Shintaro、Miyamoto Susumu、Kataoka Hiroharu、Ishii Akira、Yamamoto Kimiko、Aoki Tomohiro
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology
  
  Volume: 82 Issue: 1 Pages: 49-56
- DOI
  10.1093/jnen/nlac104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03791, KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-20K09381
[Journal Article] 脳動脈瘤を対象とした遺伝子解析と治療薬開発の現状2022
- Author(s)
  青木友浩、栢原智道、小野功朗、岡田明大
- Journal Title
  
  脳神経外科
  
  Volume: 50 Pages: 179-195
- Data Source
  KAKENHI-PROJECT-20K09381
[Journal Article] The cerebral artery in cynomolgus monkeys (<i>Macaca fascicularis</i>)2022
- Author(s)
  Keiichi Tsuji, Shinichiro Nakamura, Tomohiro Aoki, Kazuhiko Nozaki
- Journal Title
  
  Exp. Anim.
  
  Volume: 71 Issue: 3 Pages: 391-398
- DOI
  10.1538/expanim.22-0002
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09205, KAKENHI-PROJECT-19K09524
[Journal Article] The Cerebral Artery in Cynomolgus Monkeys (Macaca fascicularis)2022
- Author(s)
  Tsuji K, Nakamura S, Aoki T, Nozaki K
- Journal Title
  
  Experimental Animals
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479
[Journal Article] 脳動脈瘤モデル（橋本モデル）2021
- Author(s)
  青木友浩
- Journal Title
  
  疾患モデルの作製と利用‐循環器疾患2021　下巻
  
  Volume: 80 Pages: 294-304
- Data Source
  KAKENHI-PROJECT-20K09381
[Journal Article] Induction of CCN1 in Growing Saccular Aneurysms: A Potential Marker Predicting Unstable Lesions2021
- Author(s)
  Shimizu Kampei、Imai Hirohiko、Kawashima Akitsugu、Okada Akihiro、Ono Isao、Miyamoto Susumu、Kataoka Hiroharu、Aoki Tomohiro
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 80 Issue: 7 Pages: 695-704
- DOI
  10.1093/jnen/nlab037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-20K09381
[Journal Article] Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model2020
- Author(s)
  Shimizu Kampei、Kataoka Hiroharu、Imai Hirohiko、Yamamoto Yuto、Yamada Tomohiro、Miyata Haruka、Koseki Hirokazu、Abekura Yu、Oka Mieko、Kushamae Mika、Ono Isao、Miyamoto Susumu、Nakamura Masanori、Aoki Tomohiro
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 80 Issue: 1 Pages: 79-88
- DOI
  10.1093/jnen/nlaa131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-20K09381
[Journal Article] Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm2020
- Author(s)
  KATAOKA Hiroharu、YAGI Takanobu、IKEDO Taichi、IMAI Hirohiko、KAWAMURA Koichi、YOSHIDA Kazumichi、NAKAMURA Masanori、AOKI Tomohiro、MIYAMOTO Susumu
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 60 Issue: 7 Pages: 319-328
- DOI
  10.2176/nmc.st.2020-0072
- NAID
  130007873264
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09367, KAKENHI-PROJECT-18KT0025
[Journal Article] 脳動脈瘤のメカノバイオロジー2020
- Author(s)
  青木友浩、清水寛平、山本希美子
- Journal Title
  
  実験医学増刊「疾患に挑むメカノバイオロジー」; 循環器、運動器、がん、再生・発生に生体内の力はどうかかわるのか
  
  Volume: 38 Pages: 1096-1104
- Data Source
  KAKENHI-PROJECT-18KT0025
[Journal Article] Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis2020
- Author(s)
  Oka M, Shimo S, Ohno N, Imai H, Abekura Y, Koseki H, Miyata H, Shimizu K, Kushamae M, Ono I, Nozaki K, Kawashima A, Kawamata T, Aoki T
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 8330-8330
- DOI
  10.1038/s41598-020-65361-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-18K16599
[Journal Article] 脳動脈瘤治療の未来像2020
- Author(s)
  野崎和彦、宮田悠、青木友浩
- Journal Title
  
  脳神経外科ジャーナル
  
  Volume: 29 Pages: 101-108
- NAID
  130007801704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09479
[Journal Article] Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms2020
- Author(s)
  Kushamae M, Miyata H, Shirai M, Shimizu K, Oka M, Koseki H, Abekura Y, Ono I, Nozaki K, Mizutani T, Aoki T
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20004-20004
- DOI
  10.1038/s41598-020-74594-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-20K17929
[Journal Article] Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.2019
- Author(s)
  Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.
- Journal Title
  
  Transl Stroke Res.
  
  Volume: Epub ahead of print Issue: 1 Pages: 1-13
- DOI
  10.1007/s12975-019-0690-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17945, KAKENHI-PROJECT-19K09479, KAKENHI-PROJECT-19K22952, KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-18H03510
[Journal Article] Real-time imaging of an experimental intracranial aneurysm in rats.2019
- Author(s)
  Miyata H, Shimizu K, Koseki H, Abekura Y, Kataoka H, Miyamoto S, Nozaki K, Narumiya S, Aoki T
- Journal Title
  
  Neurol Med Chir (Tokyo)
  
  Volume: 59 Pages: 19-26
- NAID
  130007579712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09479
[Journal Article] Intracranial Aneurysm as a Macrophage-mediated Inflammatory Disease2019
- Author(s)
  Kampei Shimizu, Mika Kushamae, Tohru Mizutani, Tomohiro Aoki
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 59 Issue: 4 Pages: 126-132
- DOI
  10.2176/nmc.st.2018-0326
- NAID
  130007632867
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10719
[Journal Article] 総説炎症を通し脳動脈瘤を理解する2018
- Author(s)
  青木友浩、小関宏和、宮田悠、安部倉友、清水寛平
- Journal Title
  
  Neurological Surgery 脳神経外科
  
  Volume: 46 Issue: 4 Pages: 275-294
- DOI
  10.11477/mf.1436203718
- ISSN
  0301-2603, 1882-1251
- Year and Date
  2018-04-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16599, KAKENHI-PROJECT-16K10719
[Journal Article] 脳動脈瘤に対する新規薬物治療法・診断法開発の可能性と近未来展望2018
- Author(s)
  青木友浩
- Journal Title
  
  脳神経外科ジャーナル
  
  Volume: 27 Pages: 882-888
- NAID
  130007550030
- Data Source
  KAKENHI-PROJECT-16K10719
[Journal Article] 脳血管の慢性炎症性疾患としての脳動脈瘤の理解と薬物治療法開発への展望2018
- Author(s)
  青木友浩
- Journal Title
  
  循環器病研究の進歩
  
  Volume: 19 Pages: 66-74
- Data Source
  KAKENHI-PROJECT-16K10719
[Journal Article] A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration2017
- Author(s)
  Yamamoto Rie、Aoki Tomohiro、Koseki Hirokazu、Fukuda Miyuki、Hirose Jun、Tsuji Keiichi、Takizawa Katsumi、Nakamura Shinichiro、Miyata Haruka、Hamakawa Nozomu、Kasuya Hidetoshi、Nozaki Kazuhiko、Hirayama Yoshitaka、Aramori Ichiro、Narumiya Shuh
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 174 Issue: 13 Pages: 2085-2101
- DOI
  10.1111/bph.13820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04949
[Journal Article] Targeting macrophages to treat intracranial aneurysm.2017
- Author(s)
  Aoki T., Yamamoto R., Narumiya S.
- Journal Title
  
  Oncotarget
  
  Volume: ２８ Issue: 62 Pages: 104704-104705
- DOI
  10.18632/oncotarget.21368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10719, KAKENHI-PROJECT-17H01531
[Journal Article] Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential2017
- Author(s)
  Aoki T, Frosen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E,
- Journal Title
  
  Sci Signal
  
  Volume: 10 Issue: 465
- DOI
  10.1126/scisignal.aah6037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04949
[Journal Article] Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients2017
- Author(s)
  Aoki Tomohiro、Saito Makoto、Koseki Hirokazu、Tsuji Keiichi、Tsuji Atsushi、Murata Kiyoshi、Kasuya Hidetoshi、Morita Akio、Narumiya Shuh、Nozaki Kazuhiko
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 26 Issue: 10 Pages: 2055-2064
- DOI
  10.1016/j.jstrokecerebrovasdis.2016.10.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04949, KAKENHI-PROJECT-15K10316
[Journal Article] T cell function is dispensable for intracranial aneurysm formation and progression.2017
- Author(s)
  Miyata H., Koseki H., Takizawa K., Kasuya H., Nozaki K., Narumiya S., Aoki T.
- Journal Title
  
  PLoS ONE
  
  Volume: １２ Issue: 4 Pages: e0175421-e0175421
- DOI
  10.1371/journal.pone.0175421
- NAID
  120006309300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10719, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04949, KAKENHI-PROJECT-15K10316
[Journal Article] Prostaglandin E2-EP2-NF-kB signaling in macrophages as a potential therapeutic target2017
- Author(s)
  Aoki T, Frosen J, Fukuda M, Bando K, ShioiG, Tsuji K, Ollikainen E, Nozaki K,
- Journal Title
  
  Science Signaling
  
  Volume: 10
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04949
[Journal Article] 脳動脈瘤治療のパラダイムシフト2017
- Author(s)
  青木友浩
- Journal Title
  
  The 35th Meeting of The Mt. Fuji Workshop on CVD.
  
  Volume: 35 Pages: 1-9
- Data Source
  KAKENHI-PROJECT-16K10719
[Journal Article] T cell function is dispensable for intracranial aneurysm formation2017
- Author(s)
  Miyata H, Aoki T, Nozaki K, Narumiya S
- Journal Title
  
  PLoS One
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04949
[Journal Article] Macrophage imaging of cerebral aneurysms with ferumoxytol: an exploratory study in2017
- Author(s)
  Aoki T, Saito M, Koseki H, Tsuji K, Tsuji A,Murata K, Kasuya H, Morita A, Narumiya
- Journal Title
  
  Ｊ　Ｓｔｒｏｋｅ　Ｃｅｒｅｂ　Ｖａｓｃ　Ｄｉｓ
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04949
[Journal Article] Sustained expression of MCP-1 by low wall shear stress loading concomitant with　turbulent flow on endothelial cells of intracranial aneurysm.2016
- Author(s)
  Tomohiro Aoki, Kimiko Yamamoto, Miyuki Fukuda, Yuji Shimogonya, Shunichi　Ｆｕｋｕｄａ，　Ｓｈｕｈ　Ｎａｒｕｍｉｙａ
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26861145
[Journal Article] 脳動脈瘤形成機序の解明に基づく新規薬物治療法開発への展望2016
- Author(s)
  青木友浩
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 印刷中
- NAID
  130005253972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861145
[Journal Article] Critical role of TNF-alpha-TNFR1signaling in intracranial aneurysm formation.2014
- Author(s)
  Aoki T, Fukuda M, Nishimura M, Nozaki K, Narumiya S
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Issue: 1 Pages: 34-34
- DOI
  10.1186/2051-5960-2-34
- NAID
  120005466621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390342, KAKENHI-PROJECT-24890097
[Presentation] 脳動脈瘤破裂機構の解析とトランスレーショナル研究への展開2023
- Author(s)
  青木友浩
- Organizer
  第52回日本脳卒中の外科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 脳動脈瘤破裂機構の解析とトランスレーショナル研究への展開2023
- Author(s)
  青木友浩
- Organizer
  第52回日本脳卒中の外科学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09205
[Presentation] 近年の脳動脈瘤研究から見えてきた新たな脳動脈瘤診断治療戦略構築の可能性2022
- Author(s)
  青木友浩
- Organizer
  第31回日本脳ドック学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 脳動脈瘤の病態形成機構に基づく病理学的所見の理解2021
- Author(s)
  青木友浩
- Organizer
  第40回日本画像医学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 脳動脈瘤治療薬の探索2021
- Author(s)
  青木友浩
- Organizer
  第8回日本心血管脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] Intracranial aneurysm as a hemodynamic force-mediated inflammatory disease2021
- Author(s)
  青木友浩
- Organizer
  第60回日本生体医工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 脳動脈瘤病態におけるメカノトランスダクション機構の役割2020
- Author(s)
  青木友浩
- Organizer
  第６１回日本脈管学会総会
- Data Source
  KAKENHI-PROJECT-18KT0025
[Presentation] 脳動脈瘤病態におけるメカノトランスダクション機構の役割2020
- Author(s)
  青木友浩
- Organizer
  第６１回日本脈管学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] アンメットメディカルニーズ克服に向けた脳動脈瘤に対する新規治療法の創製2020
- Author(s)
  青木友浩
- Organizer
  第79回日本脳神経外科学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] ラット脳動脈瘤のRNA sequencing網羅的遺伝子発現解析に基づく脳動脈瘤破裂制御機構の解明2020
- Author(s)
  宮田悠, 九社前実香, 安部倉友、清水寛平, 岡美栄子, 小野功朗、野崎和彦、青木友浩
- Organizer
  第45回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 炎症依存的な動脈瘤増大を制御する因子としての血行力学的負荷：ラット動脈瘤モデルにおける検証2020
- Author(s)
  清水寛平、片岡大治、今井宏彦、山本悠斗、山田智裕、宮本享、中村匡徳、青木友浩
- Organizer
  第79回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-20K09381
[Presentation] 脳動脈瘤に対する新規薬物治療法・診断法開発の可能性と近未来展望2018
- Author(s)
  青木友浩
- Organizer
  第３８回日本脳神経外科コングレス総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] IA rodent models2018
- Author(s)
  Tomohiro Aoki
- Organizer
  Towards standardization of studies onto human and animal intracranial aneurysm wall vulnerability.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] 脳動脈瘤の発生進展と慢性炎症2018
- Author(s)
  青木友浩
- Organizer
  第37回Mt. Fuji Workshop on CVD
- Invited
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] マクロファージ依存的な脳血管の慢性炎症性疾患としての脳動脈瘤の理解2018
- Author(s)
  青木友浩
- Organizer
  第77回日本脳外科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] 脳動脈瘤形成・増大におけるT細胞機能2017
- Author(s)
  宮田悠、小関宏和、瀧澤克己、糟谷英俊、野崎和彦、青木友浩
- Organizer
  第42回日本脳卒中学会学術集会
- Place of Presentation
  大阪国際会議場（大阪、大阪市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] Rat Model of intracranial aneurysm.2017
- Author(s)
  Tomohiro Aoki
- Organizer
  Vasospasm Meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10719
[Presentation] Sustained expression of MCP-1 regardless changes in hemodynamic status during intracranial aneurysm formation/progression.2016
- Author(s)
  Tomohiro Aoki, Kimiko Yamamoto, Miyuki Fukuda, Shuh Narumiya
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-11
- Data Source
  KAKENHI-PROJECT-26861145
[Presentation] 実験的カニクイザル脳動脈瘤におけるMRIと組織学的所見の比較検討2015
- Author(s)
  辻敬一、青木友浩、野崎和彦　他
- Organizer
  第69回日本脳神経外科学会近畿支部学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-08
- Data Source
  KAKENHI-PROJECT-15H04949
[Presentation] Cerebral aneurysm as a hemodynamic stress-regulated inflammatory disease.2015
- Author(s)
  Tomohiro Aoki
- Organizer
  ICS2015 (Interdisciplinary Cerebrovascular Symposium / Intracranial Stent Meeting)
- Place of Presentation
  Gold Coast (Australia)
- Year and Date
  2015-11-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861145
[Presentation] Vascular Wall Inflammation2014
- Author(s)
  Tomohiro Aoki
- Organizer
  ICS2014
- Place of Presentation
  Zurich, Switzerland
- Year and Date
  2014-06-02
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 脳動脈瘤形成機序の解析―新規創薬への展望―2014
- Author(s)
  青木友浩
- Organizer
  第15回西埼玉脳神経集談会
- Place of Presentation
  埼玉
- Year and Date
  2014-04-18
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] Molecular basis for the development of intracranial aneurysm2013
- Author(s)
  Tomohiro Aoki
- Organizer
  Vasospasm2013
- Place of Presentation
  Lucerne,Switzerland
- Year and Date
  2013-07-03
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 脳動脈瘤形成機序の分子生物学的解析と新規創薬への展望2013
- Author(s)
  青木友浩
- Organizer
  第26回大橋ニューロカンファランス
- Place of Presentation
  東京
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 脳血管壁の慢性炎症疾患としての脳動脈瘤2013
- Author(s)
  青木友浩、成宮周
- Organizer
  第13回脳血管障害セミナー
- Place of Presentation
  東京
- Year and Date
  2013-02-16
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 脳動脈瘤形成機序の分子生物学的解析と新規創薬への展望2013
- Author(s)
  青木友浩
- Organizer
  第14回西尾久ニューロカンファ
- Place of Presentation
  東京
- Year and Date
  2013-08-21
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 基礎研究から得られた慢性炎症疾患としての脳動脈瘤形成仮説と新規治療法開発の展望2012
- Author(s)
  青木友浩、成宮周
- Organizer
  第28回日本脳神経血管内治療学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2012-11-17
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 基礎研究から得られた慢性炎症疾患としての脳動脈瘤形成仮説と新規治療法開発の展望
- Author(s)
  青木友浩
- Organizer
  第28回日本脳神経血管内治療学会学術総会
- Place of Presentation
  仙台市
- Invited
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] Molecular basis for the development of intracranial aneurysm.
- Author(s)
  青木友浩
- Organizer
  Vasospasm2013
- Place of Presentation
  Lucerne, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] 脳血管壁の慢性炎症疾患としての脳動脈瘤
- Author(s)
  青木友浩
- Organizer
  第13回脳血管障害セミナー
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24890097
[Presentation] Vascular Wall Inflammation
- Author(s)
  青木友浩
- Organizer
  ICS2014
- Place of Presentation
  Zurich, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-24890097

1. Nozaki Kazuhiko (90252452)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 辻敬一 (80838045)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. Ishii Akira (30467469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Morita Akio (60302725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 椎野顯彦 (50215935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 中村紳一朗 (50307980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 村井保夫 (30287750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 八木高伸 (00468852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 中村匡徳 (20448046)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. Araki Yoshio (80467290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kasuya Hidetoshi (50169455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Sugiyama Yoshie (60308210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 横井俊浩 (20573182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 地藤純哉 (50534161)

# of Collaborated Projects: 1 results

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15. 広田健吾 (10532690)

# of Collaborated Projects: 1 results

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16. 恩田英明 (60185692)

# of Collaborated Projects: 1 results

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17. 赤川浩之 (60398807)

# of Collaborated Projects: 1 results

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18. 米山琢 (90318105)

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19. 大継將寿 (40803086)

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20. 亦野文宏 (70557511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 白銀一貴 (70573236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 仲野和彦 (00379083)

# of Collaborated Projects: 1 results

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23. 清水則夫 (30226245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 筋野智久 (40464862)

# of Collaborated Projects: 1 results

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25. 塩澤裕介 (60801511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 杉田修啓 (20532104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 片岡大治 (40359815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
28. 氏原嘉洋 (80610021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 依馬正次 (60359578)

# of Collaborated Projects: 1 results

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30. 守村敏史 (20333338)

# of Collaborated Projects: 1 results

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31. 松本翔馬 (00881517)

# of Collaborated Projects: 1 results

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32. 河野浩人 (90894056)

# of Collaborated Projects: 1 results

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33. Koseki Hirokazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
34. MIYATA Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
35. 成宮周

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 志茂聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 山本希美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aoki Tomohiro 青木 友浩

AOKI TOMOHIRO 青木 友浩

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Identification of therapeutic targets to prevent rupture of intracranial aneurysm.Principal Investigator

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Contribution of T cell function to the pathogenesis of intracranial aneurysms.Principal Investigator

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The mechanisms underlying the enlargement of intracranial aneurysm focused on hemodynamic stress loadingPrincipal Investigator

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Clarification of mechanisms underlying the enlargement of intracranial aneurysms focused on drop-out of medial smooth muscle cells.Principal Investigator

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[Book] 最新臨床脳卒中学（第2版）下2022

Aoki Tomohiro 青木友浩

AOKI TOMOHIRO 青木友浩