SAKATA Toshiie 坂田利家

… Alternative Names

SAKATA Toshie 坂田利家

SAKATA Oosiie 坂田利家

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Researcher Number	50037420
External Links
Affiliation (based on the past Project Information) *help	2002 – 2005: NAKAMURA GAKUEN UNIVERSITY, PROFESSOR, 栄養科学研究部, 教授 2002 – 2004: 中村学園大学, 栄養科学部, 教授 1998 – 2001: 大分医科大学, 医学部, 教授 1998: 大分医科大学, 教授 1994 – 1996: 大分医科大学, 医学部, 教授 … More 1992: OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE PROFESSOR, 医学部, 教授 1991: 大分医科大学, 医学部, 助教授 1986 – 1990: 九州大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / 環境生理学(含体力医学･栄養生理学) / Metabolomics Except Principal Investigator Environmental physiology (including Physical medicine and Nutritional physiology) / Metabolomics / General pharmacology / Orthodontic/Pediatric dentistry / Circulatory organs internal medicine / 矯正・小児・社会系歯学 / Metabolomics / 医学一般 / 応用薬理学・医療系薬学
Keywords	Principal Investigator 神経ヒスタミン / 視床下部 / 糖尿病 / Histidine decarboxylase / 摂食行動 / 体温調節 / alpha-fluoromethylhistidine / 肥満 / レプチン / diabetes mellitus … More / PC-1 / 神経性食欲不振症 / ヒスチジン / HPLC / アミノ酸 / 視床下部神経分泌性ヒスタミン / α-フルオロメチルヒスチジン / 飲水行動 / カテコ-ラミン / 褐色脂肪組織 / 環境温 / 褐色脂肪細胞組織 / 視床下部性神経ペプチド / 2-デオキシ-D-グルコース(2-DG) / 2-DGの解離的調節性 / 視床下部神経ヒスタミン / 副腎 / 交感神経 / 2-deoxy-D-glucose / 視床下部外側野 / 視床下部腹内側核 / 室旁核 / CRF / Zucker遺伝性肥満ラット / ヒスチジン脱炭酸酵素 / 適応行動 / エネルギー代謝 / α-flnoromethylhistidine / 三叉神経中脳路核 / インターロイキン1-β / 視床下部グリコーゲン / 視床下部神経ヒスタミン代謝回転 / ヒスチジン脱炭酸酵素のmRNA発現量 / αーfluoromethylhistidine / 摂食の明暗周期消失 / 高温環境への適応行動 / 体温の恒常性維持 / 2ーdeoxyーDーglucoseによる遅発性摂食抑制 / Zuckerラット / ヒスタミン不応性 / 概日リズム / αーフルオロメチルヒスチジン / zucker obese rat / Hypothalamic histamine / Adaptive behavior / Thermoregulation / Genetic obesity / Energy metabolism / 脳機能 / 中枢性脂肪代謝調節 / インスリン / 脂肪酸 / 脳機能障害 / グルコーストランスポーター / グルコース作用 / 学習 / neuronal histamine / hypothalamus / leptin / memory consolidation / central regulation of lipid metabolism / insulin / fatty acids / 生活習慣病 / ドミニカ共和国 / インスリン抵抗性 / 遺伝子多型 / 疫学 / 高脂血症 / 遺伝子 / 高脂質血症 / obesity / common disease / Dominican Republic / insulin resistance / genetic polymorphism / 脱共役性蛋白 / ヒスタミン / ヒスタミン受容体1ノックアウトマウス / db / dbマウス / UCP / エネルギー代謝調節 / 肥満糖尿病 / 内臓脂肪 / agouti related ptotain / 高インスリン血症 / Zucker fatty rat / Yellow Ay mice / MC4-R / uncoupling protain / agouti related protein / uncoupling protein / Energy homeostasis / Uncoupling protein / Neuronal histamine / Leptin / Diabetes … More Except Principal Investigator 神経ヒスタミン / 視床下部 / Zucker obese rat / インスリン抵抗性 / レプチン / 肥満 / obesity / PC-1 / 咀嚼 / エネルギー代謝調節 / 食事性熱産生 / 低硬度飼料 / 液体飼料 / 糖尿病 / TNF-α / 交感神経 / 肥満症 / 食餌誘導性肥満 / Zucker fa / fa rat / OLETF rat / agouti mice / diet-induced obesity / neuronal histamine / エネルギー代謝 / energy metabolism / ドミニカ共和国 / 2型糖尿病 / 多型 / 生活習慣病 / SNP / Dominican Republic / diabetes mellitus / insulin resistance / 視床下部腹内側核 / association model / cononical correlation / causal analysis / developmental path model / latent variable / Multivariate normal distribution / contingency table / causal effect / ヒスタミン / ヒスタミン受容体 / ヒスタミン代謝酵素 / 中枢ヒスタミン神経系 / 肥満細胞 / 胃潰瘍 / 気管支喘息 / 高血圧 / 高インスリン血症 / ヒスチジンデカリポキシラーゼ / 視床下部ヒスタミン / HPLC / Hypertension / Diabetes mellitus / Hyperinsulinemia / Insulin resistence / TNF-alpha / Histidine decarboxylase / Hypothalamic histamine / レプチン抵抗性 / 脂肪酸 / Zucker fatty rat / leptin resistance / hypothalamus / fatty acid / マウス / 膵β細胞 / Differential display / MIN6 / 1型糖尿病 / HLA / スピードコンジェニック / NODマウス / cDNA / pancreatic β cell / differential display / type 1 diabetes / 唾液タンパク質 / 交感神経系 / 食事製熱産生 / 体脂肪 / mastication / Diet-induced thermogenesis / taste / sympathetic nervous system / 遺伝子解析 / 疫学 / 高脂血症 / 遺伝子多型 / genetic analysis / 肝門脈 / 食行動 / 褐色脂肪組織 / アディポネクチン / 交換神経 / hepatic-portal vein / leptin / feeding behavior / brown adipose tissue / adiponectin / ミトコンドリア / Kir6.2 / アンギオテンシンII受容体拮抗薬 / mitochondria / Kir 6.2 / antiotensin II receptor blocker / 内因性有機酸 / 視床下部外側野 / 化学感受性ニューロン / 摂食調節物質 / ラット / 迷走神経背側運動核 / 孤束核 / 内在性摂食抑制物質 / LHA / VMH / ブドウ糖感受性ニューロン / 交感神経活動 / 延髄背内側運動核 / 迷走神経 / 糖・脂肪代謝 / 摂食抑制物質 / 絶食 / 内在性有機酸 / 摂食行動調節 / 内因性摂食調節物質 / 2-DTA / 3-DPA / グルカゴン / カルチトニン / Endogenous chemical substance / Feeding behavior / Lateral hypothalamic area / Ventromedial hypothalamic nucleus / Chemosensitive neuron / 3,4-dihydroxybutanoic acid / 2,4,5-trihydroxypentanoic acid / ヒスタミンH_1受容体 / 室傍核 / 摂食行動 / 神経性分泌ヒスタミン / αーfluoromethylhistidine / ヒスタミンH_1受容体拮抗薬 / 外側視床下野 / 視床下部背内側核 / 視索前野-前視床下野 / H_1受容体 / α-fluoromethylhistidine / ニューロン活動 / Histamine H_1-receptor / Hypothalamus / Ventromedial Hypothalamus / Paraventricular Nucleus / Feeding Behavior / Neuronal Histamine Less

食育における咀嚼の重要性をエネルギー代謝調節機構から解明し肥満予防に応用する研究
- Principal Investigator
  
  中田志保, FUJISE Takako
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Kyushu University
GENOME-WIDE SEARCH FOR THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLIC
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA UNIVERSITY
  大分医科大学
The role of mastication in the mechanism of regulation of energy metabolism
- Principal Investigator
  
  FUJISE Takako, 中田稔
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Kyushu University
ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu, 坂田利家
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERSITY
Hepatic-portal leptin sensor regulates energy metabolism
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  OITA MEDICAL UNIVERSITY
STRUCTURE AND FUNCTION OF NOVEL GENE (BRG1) EXPRESSED IN PANCREATIC BETA CELLS
- Principal Investigator
  
  HAMAGUCHI Kazuyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERISTY
『国際ヒスタミン・シンポジウム』の開催準備
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
INTERNATIONAL COMPARATIVE STUDY OF OBESE DIABETES - ANALYSIS OF ENVIRONMENTALAND GENETIC FACTORS -Principal Investigator
- Principal Investigator
  
  SAKATA Toshiie
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  OITA MEDICAL UNIVERSITY
Treatment of obesity and diabetes by the neuronal factorPrincipal Investigator
- Principal Investigator
  
  SAKATA Toshiie
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERSITY
The involvement of fatty acids in the development of leptin resistance associated with obesity
- Principal Investigator
  
  YOSIMATSU Hironobu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  OITA MEDICAL UNIVERSITY
社会や医学における現象モデルと実証に関する研究
- Principal Investigator
  
  江島伸興
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
Brain function disorder in diabetes mellitus and pathophysiological role of hypothalamic neuronal histaminePrincipal Investigator
- Principal Investigator
  
  SAKATA Toshie
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  OITA MEDICAL UNIVERSITY
神経性食欲不振症の難治化する脳内ヒスタミン機能亢進とその治療法の開発Principal Investigator
- Principal Investigator
  
  坂田利家
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  大分医科大学
Involvement of brain function in the development of hypertension and hyperinsulinemia
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OITA MEDICAL UNIVERSITY
Genetically obese animal : Defect in brain histamine control of adaptative functionPrincipal Investigator
- Principal Investigator
  
  SAKATA Oosiie
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  OITA MEDICAL UNIVERSITY
  Kyushu University
脂肪細胞のエネルギ-調節機能における神経性因子とその受容体機構の解析Principal Investigator
- Principal Investigator
  
  坂田利家
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Kyushu University
Modulation of feeding behavior through brain histamine Hl-receptor
- Principal Investigator
  
  KAZUMA Fujimoto
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Medicine, Kyushu University
Control of feeding behavior and processing of hierarchial humoral information through the central and peripheral chemosensitive systems.
- Principal Investigator
  
  OKUKADO Nobuhisa, 大村裕
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  医学一般
- Research Institution
  Kyushu University

All 2005 2004

All Journal Article

[Journal Article] Hypothalamic neuronal histamine modulates febrile response but not anorexia induced by lipopolysaccharide.2005
- Author(s)
  Chiba S, Itateyama E, Oka K, Masaki T, Sakata T, Yoshimatsu H.
- Journal Title
  
  Exp Biol Med. 230
  
  Pages: 334-342
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.2004
- Author(s)
  Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LL M, Brugal V LI, Jongchong W B, Yoshimatsu H, Sakata T.
- Journal Title
  
  J Clin Endocrinol Metab. 89
  
  Pages: 1359-1364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA Polymorphism.2004
- Author(s)
  Tajima A, Hamaguchi K, Terao H, Oribe A, Perrotta VM, Baez CA, Arias JR, Yoshimatsu H, Sakata T, Horai S.
- Journal Title
  
  J Hum Genet 49
  
  Pages: 495-499
- NAID
  10013600348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035

1. YOSHIMATSU Hironobu (00166993)

# of Collaborated Projects: 14 results

# of Collaborated Products: 3 results
2. HAMAGUCHI Kazuyuki (60180931)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. AONO Hirohi (80150936)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUJISE Takako (50284518)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OOMURA Yutaka (30019517)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TERAO Hideo (10128192)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. WATANABE Takehiko (70028356)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAZUMA Fujimoto (50181392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SATO Yasufumi (50178779)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SASAKI Yasunori (70332848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OKEDA Toshimitsu (60136439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OKUKADO Nobuhisa (40037213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 中田志保 (80336081)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. KIMURA Akinori (60161551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOHNO Kimitoshi (00153479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OZAWA Hideki (90204198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WAKANA Shigeharu (90192434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. INA Keisuke (20203193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NINOMIYA Yuzo (50076048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OCHIAI Satoru (20315097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KAKUMA Tetsuya (80343359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HARA Masahide (10244162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SAKAI Kiyoshi (90153840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SHIMIZU Nobuaki (50019634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 江島伸興 (20203630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 内村和宏 (30247283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 豊沢英子 (40253801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 中野重行 (10033341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 大内和雄 (20006357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 白土邦男 (80004761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 市川厚 (10025695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 岡部進 (90012624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 大和谷厚 (30116123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 黒川衛 (70301380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 中田稔 (40014013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 片渕俊彦 (80177401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. BELLO Merced

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. LUIS ivan br

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKATA Toshiie 坂田 利家

SAKATA Toshie 坂田 利家

SAKATA Oosiie 坂田 利家

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ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator

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INTERNATIONAL COMPARATIVE STUDY OF OBESE DIABETES - ANALYSIS OF ENVIRONMENTALAND GENETIC FACTORS -Principal Investigator

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Treatment of obesity and diabetes by the neuronal factorPrincipal Investigator

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Brain function disorder in diabetes mellitus and pathophysiological role of hypothalamic neuronal histaminePrincipal Investigator

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神経性食欲不振症の難治化する脳内ヒスタミン機能亢進とその治療法の開発Principal Investigator

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SAKATA Toshiie 坂田利家

SAKATA Toshie 坂田利家

SAKATA Oosiie 坂田利家