YOSHIMATSU Hironobu 吉松博信

Researcher Number	00166993
Other IDs
Affiliation (based on the past Project Information) *help	2010 – 2014 : 大分大学, 医学部, 教授 2007 – 2008 : Oita University, 医学部, 教授 2003 – 2005 : Oita University, Faculty of Medicine, Professor, 医学部, 教授 2002 : OITA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 1999 – 2001 : DEPARTMENT OF INTERNAL MEDICINE I, SCHOOL OF MEDICINE, OOITA MEDICAL UNIVERSITY, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Environmental physiology (including Physical medicine and Nutritional physiology) / Metabolomics / Circulatory organs internal medicine / Metabolomics / Endocrinology Except Principal Investigator 内分泌・代謝学 / Metabolomics / Applied health science / 矯正・小児・社会系歯学 / Gastroenterology / Metabolomics / Orthodontic/Pediatric dentistry / 環境生理学(含体力医学･栄養生理学)
Keywords	Principal Investigator 神経ヒスタミン / 肥満 / 視床下部 / インスリン抵抗性 / Zucker obese rat / PC-1 / 肥満症 / diabetes mellitus / H1受容体 / OLETF rat … More Except Principal Investigator 神経ヒスタミン / 肥満 / 糖尿病 / レプチン / 視床下部 / HLA / UCP / エネルギー代謝調節 / チアゾリジン誘導体 / diabetes mellitus / alpha-fluoromethylhistidine / 膵β細胞 / db / IKBL / 炎症性サイトカイン / 過栄養性脂肪肝 / obesity / ヒスタミン / マウス / CRH / 食事性熱産生 / 低硬度飼料 / SNP / Histidine decarboxylase / dbマウス / 脂肪肝 / Leptin / PPARγ / 咀嚼 / Neuronal histamine / neuronal histamine / インスリン / MIN6 / 液体飼料 / 肥満症 / 1型糖尿病 / エネルギー代謝 / PC-1 / ヒスチジン / Energy metabolism / Energy homeostasis / KKAyマウス / ヒスタミン受容体1ノックアウトマウス / 視床下部グリコーゲン / 脂肪性肝炎 / グルカゴン / アディポネクチン / グルコース作用 / ヒスチジン脱炭酸酵素 / uncoupling protain / Genetic obesity / HPLC / IL-10欠損マウス / 視床下部神経ヒスタミン代謝回転 / 摂食行動 / fatty acids / 肥満糖尿病 / Apelin / 遺伝子多型 / Zucker遺伝性肥満ラット / 脾臓摘出 / 高脂血症 / 三叉神経中脳路核 / Zuckerラット / IL-10 / リズム / mastication / インターロイキン1-β / pancreatic β cell / zucker obese rat / Diet-induced thermogenesis / 生活習慣病 / αーフルオロメチルヒスチジン / カルモジュリン / 高インスリン血症 / TNF-α / 体温調節 / 膵α細胞 / Ghrelin / Dominican Republic / 転写因子 / 高温環境への適応行動 / 中枢性糖代謝改善 / インスリン抵抗性 / 脱共役性蛋白 / 抗GAD抗体 / 体脂肪 / GLP1 / 疫学 / 摂食リズム障害 / ゲノム / 脳機能 / agouti related ptotain / central regulation of lipid metabolism / hypothalamus / 2型糖尿病 / insulin / 脂肪酸 / leptin / BRG1 / ヒスタミン不応性 / Thermoregulation / differential display / glucagon / ストレプトゾトシン誘発インスリン依存性糖尿病モデルラット / Uncoupling protein / メタボリックシンドローム / 高脂質血症 / agouti related protein / pleiotropic効果 / Streptozotocin induced diabetes / pancreatic α cell / uncoupling protein / Yellow Ay mice / グルコーストランスポーター / 摂食の明暗周期消失 / type 1 diabetes mellitus / Diabetes / 中枢性脂肪代謝調節 / type 2 diabetes mellitus / 食事製熱産生 / アミノ酸 / AGRP / ８オキソグアニン / 体温の恒常性維持 / 学習 / type 1 diabetes / Zucker fatty rat / anti-GAD antibody / ピオグリタゾン / 糖利用 / 交感神経活動 / グレリン / Adaptive behavior / 唾液タンパク質 / common disease / Sympathetic nerve activity / 適応行動 / 概日リズム / ドミニカ共和国 / SREBP / α-flnoromethylhistidine / 神経性食欲不振症 / taste / 糖新生 / NODマウス / ヒスチジン脱炭酸酵素のmRNA発現量 / スピードコンジェニック / cDNA / 内臓脂肪 / insulin resistance / 交感神経系 / genetic polymorphism / MC4-R / Differential display / sympathetic nervous system / 脳機能障害 / 遺伝子 / Hypothalamic histamine / 2ーdeoxyーDーglucoseによる遅発性摂食抑制 / STZ誘発糖尿病モデル / αーfluoromethylhistidine / energy metabolism / memory consolidation Less

The investigation of feeding rhythm and obesity.
- Principal Investigator
  
  TAKAYUKI MASAKI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
The clarification of pathophysiological mechanism for over-nutritional fatty liver and the involvement of DNA damage by oxygen radical
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Oita University
ストレスと肥満症:神経ヒスタミンによる脳内メカニズムの解明Principal Investigator
- Principal Investigator
  
  吉松博信
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
Isolation of physiologically active substance regarding the pathogenesis and development of fatty liver under overeating
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Oita University
Neuronal histamine and H1 receptors regulate biological rhythm and energy metabolismPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Oita University
食育における咀嚼の重要性をエネルギー代謝調節機構から解明し肥満予防に応用する研究
- Principal Investigator
  
  中田志保, FUJISE Takako
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Kyushu University
The isolation and characterization of anti-diabetic humoral factor mediated by leptin in hypothalamus
- Principal Investigator
  
  KAKUMA Tetsuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
GENOME-WIDE SEARCH FOR THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA UNIVERSITY
  大分医科大学
FUNCTION OF NOVEL GENE (BRG1) EXPRESSED IN PANCREATIC BETA CELLS AND IMPLICATION IN PATHOGENESIS OF DIABETES.
- Principal Investigator
  
  HAMAGUCHI Kazuyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
  大分医科大学
The role of mastication in the mechanism of regulation of energy metabolism
- Principal Investigator
  
  FUJISE Takako, 中田稔
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Kyushu University
ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu, 坂田利家
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERSITY
Hepatic-portal leptin sensor regulates energy metabolismPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  OITA MEDICAL UNIVERSITY
STRUCTURE AND FUNCTION OF NOVEL GENE (BRG1) EXPRESSED IN PANCREATIC BETA CELLS
- Principal Investigator
  
  HAMAGUCHI Kazuyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERISTY
INTERNATIONAL COMPARATIVE STUDY OF OBESE DIABETES - ANALYSIS OF ENVIRONMENTALAND GENETIC FACTORS -
- Principal Investigator
  
  SAKATA Toshiie
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  OITA MEDICAL UNIVERSITY
Treatment of obesity and diabetes by the neuronal factor
- Principal Investigator
  
  SAKATA Toshiie
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERSITY
The involvement of fatty acids in the development of leptin resistance associated with obesityPrincipal Investigator
- Principal Investigator
  
  YOSIMATSU Hironobu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  OITA MEDICAL UNIVERSITY
Brain function disorder in diabetes mellitus and pathophysiological role of hypothalamic neuronal histamine
- Principal Investigator
  
  SAKATA Toshie
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  OITA MEDICAL UNIVERSITY
神経性食欲不振症の難治化する脳内ヒスタミン機能亢進とその治療法の開発
- Principal Investigator
  
  SAKATA Oosiie
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  大分医科大学
Involvement of brain function in the development of hypertension and hyperinsulinemiaPrincipal Investigator
- Principal Investigator
  
  YOSHIMATSU Hironobu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OITA MEDICAL UNIVERSITY
Genetically obese animal : Defect in brain histamine control of adaptative function
- Principal Investigator
  
  SAKATA Oosiie
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  OITA MEDICAL UNIVERSITY
  Kyushu University

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] 肥満と消化器疾患2010
- Author(s)
  吉松博信
- Publisher
  金原出版
- Data Source
  KAKENHI-PROJECT-22590988
[Book] 糖尿病ナビゲーター第2版2010
- Author(s)
  吉松博信
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590988
[Book] キーワードでわかる! メタボリツクシンドローム2008
- Author(s)
  吉松博信
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591082
[Book] キーワードでわかる! メタボリックシンドローム2008
- Author(s)
  正木孝幸吉松博信
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591082
[Book] NASH診療best approach2008
- Author(s)
  清家正隆吉松博信
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591082
[Book] 現場での疑問に答える糖尿病療養指導Q&A 寺内康夫羽倉稜子編2007
- Author(s)
  吉松博信
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591082
[Book] カラー版糖尿病学基礎と臨床門脇孝他編2007
- Author(s)
  吉松博信
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591082
[Book] 内科学第9版、杉本恒明矢崎義雄総編集2007
- Author(s)
  吉松博信
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19591082
[Book] 内科学第9版2007
- Author(s)
  吉松博信
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19591082
[Book] カラー版糖尿病学基礎と臨床2007
- Author(s)
  吉松博信
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591082
[Book] 現場での疑問に答える糖尿病診療Q&A 寺内康夫編2007
- Author(s)
  吉松博信
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Obesity-related chronic kidney disease is associated with spleen-derived IL-102013
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shiraishi K, Shimasaki T, Matsuoka K, Ando H, Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M, Yoshimatsu H
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume : 28 Pages : 1120-1130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity.2013
- Author(s)
  Shimasaki T, Masaki T, Mitsutomi K, Ueno D, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H.
- Journal Title
  
  PLoS One
  
  Volume : 8
- DOI
  10.1371/journal.pone.0063626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior.2013
- Author(s)
  Gotoh K, Masaki T, Chiba S, Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem.
  
  Volume : 125 Pages : 588-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Role of spleen in the development of steatohepatitis in high-fat-diet-induced obese rats2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Honda K, Kakuma T. Yoshimatsu H
- Journal Title
  
  Exp Biol Med
  
  Volume : 237 Pages : 461-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy.2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T, Yoshimatsu H
- Journal Title
  
  Hepatology Research
  
  Volume : 42 Pages : 203-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation.2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume : 120 Pages : 752-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced inflammation in white adipose tissue and liver2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  Diabetes
  
  Volume : 61 Pages : 1994-2003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy.2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Hepatol Res.
  
  Volume : 42 Pages : 203-212
- DOI
  10.1111/j.1872-034x.2011.00914.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Involvement of remnant spleen volume on the progression of steatohepatitis in diet-induced obese rats after a splenectomy2012
- Author(s)
  Inoue M, Gotoh K, Seike M, Masaki T, Oribe J, Honda K, Kakuma T. Yoshimatsu H
- Journal Title
  
  Hepatol Res
  
  Volume : 42 Pages : 203-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] A novel anti-inflammatory role for spleen-derived interleukin-10 in obesity-induced hypothalamic inflammation2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  J Neurochem
  
  Volume : 120 Pages : 752-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus.2012
- Author(s)
  Masaki T, Anan F, Shimomura T, Fujiki M, Saikawa T, Yoshimatsu H.
- Journal Title
  
  Metabolism.
  
  Volume : 61 Pages : 1197-1200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] A Novel Anti-Inflammatory Role for Spleen-Derived Interleukin-10 in Obesity-induced Inflammation in White Adipose Tissue and Liver2012
- Author(s)
  Gotoh K, Inoue M, Masaki T, Chiba S, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H.
- Journal Title
  
  Diabetes
  
  Volume : 61 Pages : 1994-2003
- DOI
  10.2337/db11-1688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Apelin-13 microinjection into the paraventricular nucleus increased sympathetic nerve activity innervating brown adipose tissue in rats.2012
- Author(s)
  Masaki T, Yasuda T, Yoshimatsu H.
- Journal Title
  
  Brain Res Bull.
  
  Volume : 87 Pages : 540-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic Fatty pancreas disease2012
- Author(s)
  Gotoh K, Inoue M, Shiraishi K, Masaki T, Chiba S, Mitsutomi K, Shimasaki T, Ando H, Fujiwara K, Katsuragi I, Kakuma T, Seike M, Sakata T, Yoshimatsu H
- Journal Title
  
  PLoS One
  
  Volume : 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Intracerebroventricular administration of urotensin II regulates food intake and sympathetic nerve activity in brown adipose tissue.2012
- Author(s)
  Yasuda T, Masaki T, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Peptides.
  
  Volume : 35 Pages : 131-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] Intraperitoneal administrartion attenuates thiazolidinedions-induced hepatic steatosis in KKAy mice with increased hepatic peroxisome proliferator-activated receptor (PPAR)γ mRNA expression2012
- Author(s)
  Oribe J, Kakuma T, Haranaka M, Okamoto K, Seike M, Yoshimatsu H
- Journal Title
  
  Obes Res Clin Prac
  
  Volume : 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500846
[Journal Article] Ghrelin in small intestine, its contribution to regulation of food intake and body weight in cross-intestinal parabiotic rats.2011
- Author(s)
  Noguchi H, Masaki T, Kakuma T, Nakazato M, Yoshimatsu H
- Journal Title
  
  Endocrine Journal
  
  Volume : 58 Pages : 625-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500845
[Journal Article] 肥満症(第2版)基礎・臨床研究の進歩肥満症治療の意義と展望2010
- Author(s)
  吉松博信
- Journal Title
  
  日本臨床
  
  Volume : 68増刊号 Pages : 26-35
- Data Source
  KAKENHI-PROJECT-22590988
[Journal Article] 神経内分泌系におけるストレス反応と糖尿病2010
- Author(s)
  吉松博信
- Journal Title
  
  Diabetes Frontier
  
  Volume : 21 Pages : 451-456
- Data Source
  KAKENHI-PROJECT-22590988
[Journal Article] Acute central administration of immepip, a histamine H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats2009
- Author(s)
  Chiba S, Itateyama E, Sakata T, Yoshimatsu H.
- Journal Title
  
  Brain Res Bull 79
  
  Pages : 37-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Adrenomedullin Improves cardiac expression of heat-shock protein 72 and tolerance against Ischemia/reperfusion injury in insulin-resistant rats2009
- Author(s)
  Torigoe Y, Takahashi N, Hara M, Yoshimatsu H, Saikawa T.
- Journal Title
  
  Endocrinology 150
  
  Pages : 1450-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] FUNCTIONAL POTENTIATION OF LEPTIN-STAT3 SIGNALING BY THE ANDROGEN RECEPTOR2008
- Author(s)
  Fan W, Yanase T, Nishi Y, Chiba S, Okabe T, Nomura M, Yoshimatsu H, Kato S, Takayanagi R, Nawata H.
- Journal Title
  
  Endocrinology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Effects of Pravastatin on Obesity, Diabetes, and Adiponectin in Diet-induced Obese Mice2008
- Author(s)
  Araki K, Masaki T, Katsuragi I, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Obesity (Silver Spring)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm2008
- Author(s)
  Yoshimatsu H
- Journal Title
  
  Nutrition 24
  
  Pages : 827-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Effects of pravastatin on obesity, diabetes, and adiponectin in diet-induced obese mice2008
- Author(s)
  Araki K, Masaki T, Katsuragi I, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Obesity (SilverSpring) 16(9)
  
  Pages : 2068-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Hypothalamic neuronal histamine regulates body weight through the modulation of diurnal feeding rhythm.2008
- Author(s)
  Yoshimatsu H
- Journal Title
  
  Nutrition 24
  
  Pages : 827-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake2007
- Author(s)
  Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem 103
  
  Pages : 1102-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)2007
- Author(s)
  Endo M, Masaki T, Seike M, Yoshimatsu H.
- Journal Title
  
  Exp Biol Med (Maywood) 232(5)
  
  Pages : 614-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)2007
- Author(s)
  Endo M, Masaki T, Seike M, Yoshimatsu H.
- Journal Title
  
  Exp Biol Med (Maywood) 232
  
  Pages : 614-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice2007
- Author(s)
  Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Endocrinology 148(6)
  
  Pages : 2690-2697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice2007
- Author(s)
  Higuchi K, Masaki T, Gotoh K, Chiba S, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Endocrinology 148
  
  Pages : 2690-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake2007
- Author(s)
  Gotoh K, Fukagawa K, Fukagawa T, Noguchi H, Kakuma T, Sakata T, Yoshimatsu H.
- Journal Title
  
  J Neurochem 103(3)
  
  Pages : 1102-1110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Involvement of stomach ghrelin and hypothalamic neuropeptides in tumor necrosis factor-alpha-induced hypophagia in mice2007
- Author(s)
  Endo M, Masaki T, Seike M, Yoshimatsu H.
- Journal Title
  
  Regul Pept. 140
  
  Pages : 94-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591082
[Journal Article] The neuronal histamine H1 and pro-opiomelanocortin-melancortin 4 receptors independent regulation of food intake and energy expenditure.2006
- Author(s)
  Yoshimatsu H.
- Journal Title
  
  Peptides 27
  
  Pages : 326-332
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Sterol regulatory element binding protein(SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes2006
- Author(s)
  Okamoto K, Kakuma T, Fukuchi S, Masaki T, Sakata T, Yoshimatsu H.
- Journal Title
  
  Brain Res. 1081(1)
  
  Pages : 19-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice2006
- Author(s)
  Araki K, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Hypertension 48(1)
  
  Pages : 51-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury.2005
- Author(s)
  Masaki T, Chiba S, Tatsukawa H, Noguchi H, Kakuma T, Endo M, Seike M, Watanabe T, Yoshimatsu H.
- Journal Title
  
  FASEB J. 19
  
  Pages : 1245-1252
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury2005
- Author(s)
  Masaki T, Chiba S, Tatsukawa H, Noguchi H, Kakuma T, Endo M, Seike M, Watanabe T, Yoshimatsu H.
- Journal Title
  
  FASEB J. 19(10)
  
  Pages : 1245-1252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice.2005
- Author(s)
  Tsubone T, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Regul Pept. 130
  
  Pages : 97-103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Hypothalamic neuronal histamine modulates febrile response but not anorexia induced by lipopolysaccharide.2005
- Author(s)
  Chiba S, Itateyama E, Oka K, Masaki T, Sakata T, Yoshimatsu H.
- Journal Title
  
  Exp Biol Med. 230
  
  Pages : 334-342
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice.2005
- Author(s)
  Tsubone T, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol. 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA Polymorphism.2004
- Author(s)
  Tajima A, Hamaguchi K, Terao H, Oribe A, Perrotta VM, Baez CA, Arias JR, Yoshimatsu H, Sakata T, Horai S
- Journal Title
  
  J Hum Genet 49
  
  Pages : 495-499
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Journal Article] Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice2004
- Author(s)
  Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, Yoshimatsu H.
- Journal Title
  
  Hepatology 40(1)
  
  Pages : 177-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590779
[Journal Article] The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.2004
- Author(s)
  Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LL M, Brugal V LI, Jongchong W B, Yoshimatsu H, Sakata T
- Journal Title
  
  J Clin Endocrinol Metab 89
  
  Pages : 1359-1364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Journal Article] IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese.2004
- Author(s)
  Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H
- Journal Title
  
  Tissue Antigens 63
  
  Pages : 223-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Journal Article] The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.2004
- Author(s)
  Hamaguchi K, Terao H, Kusuda Y, Yamashita T, Hazoury Bahles JA, Cruz LL M, Brugal V LI, Jongchong W B, Yoshimatsu H, Sakata T.
- Journal Title
  
  J Clin Endocrinol Metab. 89
  
  Pages : 1359-1364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes.2004
- Author(s)
  Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahasi M, Abe N, Yoshimatsu H
- Journal Title
  
  Diabetes Res Clin Pract 66
  
  Pages : 163-171
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Journal Article] Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA Polymorphism.2004
- Author(s)
  Tajima A, Hamaguchi K, Terao H, Oribe A, Perrotta VM, Baez CA, Arias JR, Yoshimatsu H, Sakata T, Horai S.
- Journal Title
  
  J Hum Genet 49
  
  Pages : 495-499
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15406035
[Journal Article] Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats.2004
- Author(s)
  Fukuchi S, Hamaguchi K, Seike M, Himeno K, Sakata T, Yoshimatsu H
- Journal Title
  
  Exp Biol Med (Maywood) 229
  
  Pages : 486-493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Journal Article] Cellular interaction between mouse pancreatic α-cell and β-cell lines : possible contact-dependent inhibition of insulin secretion.2003
- Author(s)
  Hamaguchi K, Utsunomiya N, Takaki R, Yoshimatsu H, Sakata T
- Journal Title
  
  Exp Biol Med (Maywood) 228
  
  Pages : 1227-1233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571102
[Presentation] 肥満に伴う視床下部内の慢性炎症における脾臓由来IL-10の役割2012
- Author(s)
  後藤孔郎, 井上恵, 正木孝幸, 千葉政一, 嶋崎貴信, 安藤久恵, 藤原貫為, 葛城功, 加隈哲也, 清家正隆, 坂田利家, 吉松博信
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500846
[Presentation] 肥満糖尿病の最新の治療2011
- Author(s)
  正木孝幸、吉松博信
- Organizer
  第49回日本糖尿病学会九州地方会(招待講演)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23500845
[Presentation] 新しい糖尿病治療の展望2011
- Author(s)
  正木孝幸、吉松博信
- Organizer
  第54回日本糖尿病学会学術集会(招待講演)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23500845
[Presentation] 肥満糖尿病患者に対する行動療法2010
- Author(s)
  吉松博信
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  ホテルグランヴィア岡山
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22590988
[Presentation] 中枢神経系からアプローチする新たな肥満症治療ターゲット神経ヒスタミンによる視床下部機能のクロストーク2008
- Author(s)
  吉松博信
- Organizer
  第29回日本肥満学会
- Place of Presentation
  大分
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満糖尿病マウスにおいてチアゾリジン誘導体による脂肪肝増悪の機序2008
- Author(s)
  織部淳哉、清家正隆、加隈哲也、原中美環、岡本健二郎、吉松博信
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 中枢神経系からアプローチする新たな肥満症治療ターゲット神経ヒスタミンによる視床下部機能のクロストーク2008
- Author(s)
  吉松博信
- Organizer
  第29回日本肥満学会
- Place of Presentation
  大分
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満症の新たな治療戦略2008
- Author(s)
  吉松博信
- Organizer
  第63回日本体力医学会大会
- Place of Presentation
  大分
- Year and Date
  2008-09-19
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満症治療の新たなアプローチ2008
- Author(s)
  吉松博信
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 摂食障害における脳内ストレス情報処理と神経ヒスタミン2008
- Author(s)
  吉松博信
- Organizer
  第4回日本摂食障害学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 抗肥満薬の最新の動向2008
- Author(s)
  吉松博信
- Organizer
  第1回日本肥満症治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満症治療の新たな展開2008
- Author(s)
  吉松博信
- Organizer
  第81回日本内分泌学会学術総会
- Place of Presentation
  青森
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満糖尿病マウスにおけるチアゾリジン誘導体の肝臓、代謝への影響2007
- Author(s)
  織部淳哉、清家正隆、加隈哲也、荒川光江、遠藤美月、吉松博信
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] 肥満症治療の展望2007
- Author(s)
  吉松博信
- Organizer
  第57回日本体質医学会総会
- Place of Presentation
  大分
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 糖尿病合併脂肪肝症例と非脂肪肝症例の予後の検討2007
- Author(s)
  織部淳哉、清家正隆、針里栄、井上恵、姫野克郎、高橋祐幸、加隈哲也、吉松博信
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-19590779
[Presentation] メタボリックシンドロームの病態と治療2007
- Author(s)
  吉松博信
- Organizer
  第43回日本赤十字社医学会総会
- Place of Presentation
  大分
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満症の新たな治療戦略2007
- Author(s)
  吉松博信
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19591082
[Presentation] 肥満症の正しい理解と治療2007
- Author(s)
  吉松博信
- Organizer
  第45回全国大学保健管理研究集会
- Place of Presentation
  大分
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19591082

1. SAKATA Oosiie (50037420)

# of Collaborated Projects : 14results

# of Collaborated Products : 3results
2. KAKUMA Tetsuya (80343359)

# of Collaborated Projects : 8results

# of Collaborated Products : 28results
3. HAMAGUCHI Kazuyuki (60180931)

# of Collaborated Projects : 6results

# of Collaborated Products : 8results
4. AONO Hirohi (80150936)

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5. TAKAYUKI MASAKI (00423715)

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6. FUJISE Takako (50284518)

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7. SEIKE Masataka (40253794)

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8. TERAO Hideo (10128192)

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9. WAKANA Shigeharu (90192434)

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10. SATO Yasufumi (50178779)

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11. SASAKI Yasunori (70332848)

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12. OKEDA Toshimitsu (60136439)

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13. INA Keisuke (20203193)

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14. 中田志保 (80336081)

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15. GOTO Koro (10457624)

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16. CHIBA Seiichi (20457633)

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17. KIMURA Akinori (60161551)

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18. KOHNO Kimitoshi (00153479)

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19. WATANABE Takehiko (70028356)

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20. OZAWA Hideki (90204198)

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21. NINOMIYA Yuzo (50076048)

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22. OCHIAI Satoru (20315097)

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23. HARA Masahide (10244162)

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24. 藤本一眞 (50181392)

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25. 大和谷厚 (30116123)

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26. 黒川衛 (70301380)

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27. 中田稔 (40014013)

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28. BELLO Merced

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29. LUIS ivan br

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YOSHIMATSU Hironobu 吉松 博信

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ストレスと肥満症:神経ヒスタミンによる脳内メカニズムの解明Principal Investigator

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Neuronal histamine and H1 receptors regulate biological rhythm and energy metabolismPrincipal Investigator

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GENOME-WIDE SEARCH FOR THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator

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ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLICPrincipal Investigator

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Hepatic-portal leptin sensor regulates energy metabolismPrincipal Investigator

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YOSHIMATSU Hironobu 吉松博信

[Book] 糖尿病ナビゲーター第2版2010

[Book] 現場での疑問に答える糖尿病療養指導Q&A 寺内康夫羽倉稜子編2007

[Book] カラー版糖尿病学基礎と臨床門脇孝他編2007