Nagaoka Satoshi 長岡利

… Alternative Names

Researcher Number	50202221
Other IDs
External Links
Affiliation (Current)	2019: 岐阜大学, 応用生物科学部, 教授
Affiliation (based on the past Project Information) *help	2007 – 2019: Gifu University, 応用生物科学部, 教授 2004 – 2006: 岐阜大学, 応用生物科学部, 助教授 1997 – 2003: 岐阜大学, 農学部, 助教授 1993 – 1995: 岐阜大学, 農学部, 助教授
Review Section/Research Field	Principal Investigator Food science / 食品科学・栄養科学 / Applied molecular and cellular biology / Eating habits Except Principal Investigator Zootechnical science/Grassland science / Food science / Medium-sized Section 27:Chemical engineering and related fields / 食品科学・栄養科学 / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator コレステロール / HepG2 / 胆汁酸 / 動脈硬化 / ポリフェノール / ラクトスタチン / ペプチドアレイ / ミセル / アポリポタンパク質A-I / コレステロール7α-水酸化酵素 … More Except Principal Investigator 牛乳 / 糖タンパク質 / カテキン / ロタウィルス / 細胞感染実験 / 動物感染実験 / コレステロール / ウーロン茶 / α-ラクトアルブミン / ウーロンテアニン / ヒトロタウィルス / ウーロン茶ポリフェノール / ミルクムチン / ウィルス中和活性 / IEC-6 / 培養細胞 / アポトーシス / human rotavirus / Catechin / 酸化 / オボムチン / ウーロン茶高分子ポリフェノール / タウロコール酸 / α^-ラクトアルブミン / Oolong tea / 分化誘導 / Rotavirus Infection / ミルクムチン複合体 / 抗がん作用 / apoptosis / urease / ペプチド / ovomucin / Prooolongtheanin / 乳飲みマウス / Neutralization / 下痢の治癒 / 卵白蛋白質 / ウレアーゼ / コンフォメーション / F(ab‘)_2 / Cow Colostrum / コレステロール吸収 / antitumor activity / oral administration / IgG / inhibition of infection / Polymeric polyphenol / 免疫グロブリン / ロタウイルス / Oolomgtheanin / 経口投与 / コレステロール吸収阻害 / healing from diarrhea / Glycoprotein / 中和活性 / 抗腫瘍活性 / 烏龍茶ポリフェノール / antibody / β-lactoglobulin / α-lactalbumin / コレステロール低下作用 / Protective Function / 特異抗体 / cow's milk / 機能性食品 / 可食性タンパク質 / Dehydrotheasinensin / egg white protein / ウシ初乳 / ピロリ菌 / 探索 / 抗体 / 情報解析 / hypocholesterolemic action / 腫瘍細胞 / lgG / 反応機構 / milk mucin complex / β-ラクトグロブリン / Oxidaiton / F (ab) _2 / Helicobacter pylori / suckling mice / コレステロール吸収抑制 / 卵白タンパク質 / β^-ラクトグロブリン / Oolongtheanin / 感染阻害作用 / ウイルス中和活性 / 酸化反応 / 成長促進作用 / コレステロールミセル溶解性 / Cow Milk / 成長停止 / 腸輸送 / cell growth arrest / フォールディング変異体 / 脂質代謝改善作用 Less

Exploring of functional peptides from edible proteins and establishment of oral administration without activity lossOngoing
- Principal Investigator
  
  本多裕之
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 27:Chemical engineering and related fields
- Research Institution
  Nagoya University
ウーロン茶の生理機能発現メカニズム解析を指向した高分子ポリフェノールの構造研究Ongoing
- Principal Investigator
  
  柳瀬笑子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Gifu University
Fundamental study on the lipid lowering peptides derived from food proteinsPrincipal InvestigatorOngoing
- Principal Investigator
  
  長岡利
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Eating habits
- Research Institution
  Gifu University
Chemical studies of oolong tea polyphenol and molecular mechanism of its bioactivity
- Principal Investigator
  
  YANASE Emiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Gifu University
Discovery of Innovative lipid lowering peptides by targetting the bio-molecule and Creation of novel screening technologyPrincipal Investigator
- Principal Investigator
  
  Nagaoka Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Gifu University
The clarification and application of a novel regulatory mechanism of cholesterol metabolism mediated by polyphenols.Principal Investigator
- Principal Investigator
  
  Nagaoka Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Food science
- Research Institution
  Gifu University
Elucidation of formation mechanism of oolong tea polyphenol: Oolongtheanins
- Principal Investigator
  
  YANASE Emiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Food science
- Research Institution
  Gifu University
Identification, exhaustive analysis, clarification of action mechanism and efficient modification of novel hypolipidemic peptidesPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Gifu University
ポリフェノールの脂質代謝改善作用に関与する新規情報伝達系の解明Principal Investigator
- Principal Investigator
  
  長岡利
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Food science
- Research Institution
  Gifu University
The clarification and application of mechanism of hypocholesterolemic peptides by peptide arrayPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Gifu University
ポリフェノールの媒介する新しい情報伝達機構の解明と細胞機能Principal Investigator
- Principal Investigator
  
  長岡利
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Gifu University
ラクトスタチンの媒介する新規コレステロール代謝調節系の解明Principal Investigator
- Principal Investigator
  
  長岡利
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Food science
- Research Institution
  Gifu University
Mechanism of action of new hypocholesterolemic pentapeptideiPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Satoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Gifu University
Regulation of Intestinal CeIl Growth by Bavine Milk Proteins : Prevention and Healing from Gastroenteritis
- Principal Investigator
  
  KANAMARU Yoshihiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Gifu University
牛乳蛋白貭によるアポトーシス誘導とその感染予防・治療における役割
- Principal Investigator
  
  KANAMARU Yoshihiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Gifu University
The analysis of the mechanism of the anti-atherogenic action of polyphenol utilizing new evaluation technologyPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Satoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Gifu University
The relationships between molecular structure and various food-physiological.functions of egg white ovomucin : analysis and application
- Principal Investigator
  
  KENII Watanabe
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Tokyo University of Agriculture
  Gifu University
Cow's milk-based functional foods that can prevent gastroenteritis
- Principal Investigator
  
  KANAMARU Yoshihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  GIFU UNIVERSITY
New screenings of the improving factors for lipid metabolism derived from foods and their functional evaluationPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Satoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Gifu University
卵オボムチンの経口投与による生物活性発現の解析
- Principal Investigator
  
  KENII Watanabe
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Gifu University
動物実験系及び培養細胞系を用いた牛乳ムチンの生理機能評価
- Principal Investigator
  
  金丸義敬
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Gifu University
抗動脈硬化作用を発現する乳清蛋白質由来の新規ペプチドに関する研究Principal Investigator
- Principal Investigator
  
  長岡利
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Gifu University
Oral Passive Immunization with Cow Milk Immunoglobulin. Developmental Basis for A Food WITH Prophylactic Function.
- Principal Investigator
  
  KANAMARU Yoshihiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  GIFU UNIVERSITY

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 「タンパク質, ペプチド, アミノ酸を用いた脂質代謝を改善する特定保健用食品及び機能性食品について」『医用機能性食品ガイドブック』2012
- Author(s)
  長岡利
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23380075
[Book] Ameliorative action of peptides on cholesterol and lipid metabolism from the viewpoint of peptide-lipid interactions. Chapter XV : Peptide-lipid interactions and functionalities, Food Proteins and Peptides : Chemistry, Functionality, and Commercialization2012
- Author(s)
  Satoshi Nagaoka
- Total Pages
  454
- Publisher
  CRC Press Taylor & Francis Group
- Data Source
  KAKENHI-PROJECT-23380075
[Book] 医用機能性食品ガイドブック、たんぱく質、ペプチド、アミノ酸を用いた脂質代謝を改善する特定保健用食品および機能性食品2012
- Author(s)
  長岡　利
- Total Pages
  145
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23380075
[Book] Ameliorative action of peptides on cholesterol and lipid metabolism from the viewpoint of peptide-lipid interactions. Chapter XV: Peptide-lipid interactions and functionalities, Food Proteins and Peptides: Chemistry, Functionality, and Commercialization2011
- Author(s)
  Nagaoka, S
- Data Source
  KAKENHI-PROJECT-23380075
[Book] 第2章食品タンパク質由来の脂質代謝改善ペプチド(機能性タンパク質・ペプチドと生体利用)2010
- Author(s)
  長岡利
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-20380075
[Book] 機能性タンパク質・ペプチドと生体利用,(第2章食品タンパク質由来の脂質代謝改善ペプチド)2010
- Author(s)
  長岡利
- Total Pages
  235
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-20380075
[Book] 種子の科学とバイオテクノロジー、8-1-5ダイスの生理機能性ペプチド2009
- Author(s)
  長岡利
- Publisher
  学会出版センター
- Data Source
  KAKENHI-PROJECT-20380075
[Book] 第5章第1節タンパク質の機能性, 6項ペプチド, 6-2 コレステロール代謝改善(大豆のすべて)2009
- Author(s)
  長岡利
- Publisher
  サイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-20380075
[Book] 第9章コレステロール代謝改善ペプチド(機能性ペプチドの最新応用技術)2009
- Author(s)
  長岡利
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-20380075
[Book] Lactostatin (IIAEK) and SPHP : New Cholesterol-Lowering Peptides Derived from Food Proteins. In "Dietary Fat and Risk of Common Diseases"2006
- Author(s)
  Satoshi Nagaoka et al.
- Publisher
  American Oil Chemist's Society (AOCS) Press
- Data Source
  KAKENHI-PROJECT-18658136
[Book] Cholesterol-lowering proteins and peptides, in "Nutraceutical proteins and peptides in health and disease"2005
- Author(s)
  Satoshi Nagaoka
- Total Pages
  20
- Publisher
  Taylor and Francis Group
- Data Source
  KAKENHI-PROJECT-16658056
[Book] 種子のバイオサイエンス(改訂版)(8.種子成分と食品機能性, 8-1-5ダイズの生理機能性ペプチド)
- Author(s)
  長岡利
- Publisher
  学会出版センター
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] Nutrition and Food Science Studies of Cholesterol Metabolism Regulation2018
- Author(s)
  長岡　利
- Journal Title
  
  J Jpn Soc Nutr Food Sci
  
  Volume: 71 Issue: 1 Pages: 11-20
- DOI
  10.4327/jsnfs.71.11
- ISSN
  0287-3516, 1883-2849
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00817
[Journal Article] Structure-function properties of hypolipidemic peptides2018
- Author(s)
  Nagaoka, S.
- Journal Title
  
  J. Food Biochem.
  
  Volume: －
- DOI
  10.1111/jfbc.12539
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00817
[Journal Article] コレステロール代謝を改善する食品成分に関する基礎研究2018
- Author(s)
  長岡　利
- Journal Title
  
  明日の食品産業
  
  Volume: 484 Pages: 40-50
- Data Source
  KAKENHI-PROJECT-17H00817
[Journal Article] Mystery of cholesterol lowering peptide, lactostatin and soystatin2018
- Author(s)
  Nagaoka, S.
- Journal Title
  
  J. Agric. Food Chem.
  
  Volume: －
- DOI
  10.1021/acs.jafc.8b01025
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00817
[Journal Article] Epigallocatechin gallate induces an up-regulation of LDL receptor accompanied by a reduction of PCSK9 via the annexin A2-independent pathway in HepG2 cells.2017
- Author(s)
  Kohei Kitamura, Yudai Okada, Kenji Okada, Yuya Kawaguchi and Satoshi Nagaoka
- Journal Title
  
  Mol. Nutr. Food Res.
  
  Volume: 印刷中
- DOI
  10.1002/mnfr.201600836
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292067
[Journal Article] New Development of the Study on Lifestyle-Related Disease Preventive and Improvement Action of Peptides Derived from Food Proteins2017
- Author(s)
  長岡　利
- Journal Title
  
  KAGAKU TO SEIBUTSU
  
  Volume: 54 Issue: 11 Pages: 804-811
- DOI
  10.1271/kagakutoseibutsu.54.804
- ISSN
  0453-073X, 1883-6852
- Year and Date
  2017-10-20
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26292067
[Journal Article] コレステロール代謝改善ペプチド2017
- Author(s)
  長岡　利
- Journal Title
  
  FFIジャーナル
  
  Volume: 222 Pages: 194-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00817
[Journal Article] Identification of the active protein in rice bran protein having an inhibitory activity of cholesterol micellar solubility.2017
- Author(s)
  Jilt Wang, Masaya Shimada and Satoshi Nagaoka
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 印刷中
- DOI
  10.1080/09168451.2017.1282811
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292067
[Journal Article] Interaction between tea polyphenols and bile acid inhibits micellar cholesterol solubility.2016
- Author(s)
  Ogawa, Kazuki; Hirose, Sayumi; Nagaoka, Satoshi; Yanase, Emiko
- Journal Title
  
  J. Agric. Food Chem.
  
  Volume: 64（1） Pages: 204-209
- DOI
  10.1021/acs.jafc.5b05088
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07427, KAKENHI-PROJECT-26292067
[Journal Article] Synthesis of oolongtheanins and their inhibitory activity on micellar　cholesterol solubility in vitro.2015
- Author(s)
  Ogawa, K., Hirose, S., Yamamoto, H., Shimada, M., Nagaoka, S. and Yanase, E.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Pages: 749-752
- DOI
  10.1016/j.bmcl.2015.01.002
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780123
[Journal Article] Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells.2013
- Author(s)
  Nagaoka Satoshi
- Journal Title
  
  Mol.Nutr.Food Res.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells2013
- Author(s)
  Goto, T., Mori, A. and Nagaoka, S
- Journal Title
  
  Nutr. Food Res
  
  Volume: 57 Pages: 1435-1445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] 乳成分の脂質代謝改善作用‐乳清ペプチドを中心に‐2012
- Author(s)
  長岡利
- Journal Title
  
  ミルクサイエンス
  
  Volume: No.61 Pages: 253-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis.2011
- Author(s)
  Takeshita, T., Okochi, M., Kato, R., Kaga, C.,Tomita, Y., Nagaoka, S., Honda, H.
- Journal Title
  
  J.Biosci.Bioeng. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis2011
- Author(s)
  Satoshi Nagaoka, ら
- Journal Title
  
  J.Biosci.Bioeng.
  
  Volume: 112 Pages: 92-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis2011
- Author(s)
  Takeshita, T., Okochi, M., Kato, R., Kaga, C., Tomita, Y., Nagaoka, S. and Honda, H
- Journal Title
  
  J. Biosci. Bioeng
  
  Volume: 112 Pages: 92-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] ペプチドアレイによる大豆たん白質由来の新規疎水性胆汁酸結合ペプチドの網羅解析およびin vivoでの作用機構解析2011
- Author(s)
  長岡利
- Journal Title
  
  大豆たん白質研究
  
  Volume: 14 Pages: 48-52
- Data Source
  KAKENHI-PROJECT-23380075
[Journal Article] Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats.2010
- Author(s)
  Nagaoka, S., Nakamura, A., Shibata, H., Kanamaru, Y.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages: 1738-1741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats.2010
- Author(s)
  Nagaoka, S., Nakamura, A., Shibata, H., Kariamaru, Y.
- Journal Title
  
  Biosci.Biotechnol.Biochem.
  
  Volume: 74 Pages: 1738-1741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article]2009
- Author(s)
  長岡利
- Journal Title
  
  機能性ペプチドの最新応用技術(コレステロール代謝改善ペプチド)(シーエムシー出版)
  
  Pages: 86-95
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] The cattle heart protein hydrolysate ameliorates hypercholesterolemia accompanying with the suppression of cholesterol absorption in rats and Caco-2 cells.2009
- Author(s)
  Nakade, K., Kaneko, H.Oka, T., Ahhmed, A.M., Muguruma, M., Numata, M., Nagaoka, S.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 73
  
  Pages: 607-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] The cattle heart protein hydrolysate ameliorates hypercholesterolemia accompanying with the suppression of cholesterol absorption in rats and Caco-2 cells.2009
- Author(s)
  Satoshi Nagaoka, et al.
- Journal Title
  
  Biosci. Biotech. Biochem. 73
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380075
[Journal Article] A novel regulatory pathway for cholesterol degradation via lactostatin.2007
- Author(s)
  Satoshi Nagaoka et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 352
  
  Pages: 697-702
- Data Source
  KAKENHI-PROJECT-18658136
[Journal Article] Effects of dipeptides having a C-terminal lysine on the cholesterol 7α-hydroxylasemRNA level in HepG2 cells.2007
- Author(s)
  Satoshi Nagaoka
- Journal Title
  
  Biosci. Biotech. Biochem. 71
  
  Pages: 821-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18658136
[Journal Article] Involvement of SDS-Stable Higher Mr Forms of Bovine Milk α-Lactalbumin in Inducing Intestinal IEC-6 Cell Death2005
- Author(s)
  Xu, M., Sugiura, Y., Nagaoka, S., Kanamaru, Y.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13460117
[Journal Article] IEC-6 Intestinal Cell Death Induced by Bovine Milk α-Lactalbumin2005
- Author(s)
  Xu, M., Sugiura, Y., Nagaoka, S., Kanamaru, Y.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13460117
[Journal Article] A Novel Protein C-Phycocyanin Plays a Crucial Role in the Hypocholesterolemic Action of Spirulina platensis Concentrate in Rats2005
- Author(s)
  Satoshi Nagaoka
- Journal Title
  
  Journal of Nutrition 135・10
  
  Pages: 2425-2430
- Data Source
  KAKENHI-PROJECT-16658056
[Presentation] タンパク質、ペプチド、アミノ酸の脂質代謝調節機能2017
- Author(s)
  長岡　利
- Organizer
  第72回日本栄養・食糧学会中部支部大会（岐阜）
- Invited
- Data Source
  KAKENHI-PROJECT-17H00817
[Presentation] ラクトスタチン（IIAEK）は肝特異的転写因子HNF-3αを介してコレステロール分解を促進する2017
- Author(s)
  大林由季奈、磯貝渚、井辰かおる、島田昌也、長岡利
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] Interaction between Bile Acid and Tea Catechins Inhibits Micellar Cholesterol Solubility2017
- Author(s)
  Takumi Sakakibara, Kazuki Ogawa, Satoshi Nagaoka, and Emiko Yanase
- Organizer
  International Symposium on Natural Medicines 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07427
[Presentation] タンパク質、ペプチド、アミノ酸の脂質代謝調節機能2017
- Author(s)
  長岡　利
- Organizer
  国際アミノ酸科学協会　第25回アミノ酸セミナー：基礎と臨床を結ぶ会
- Invited
- Data Source
  KAKENHI-PROJECT-17H00817
[Presentation] Hypocholesterolemic Pentapeptide Lactostatin (IIAEK) Activates Cholesterol Degradation via Hepatocyte Nuclear Factor 3α in HepG2 cells2017
- Author(s)
  Nagaoka, S.
- Organizer
  ISNFF 2017 (Gunsan, Jeonbuk, Korea)
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17H00817
[Presentation] Hypocholesterolemic Pentapeptide Lactostatin (IIAEK) Activates Cholesterol Degradation via Hepatocyte Nuclear Factor 3α in HepG2 cells2017
- Author(s)
  Nagaoka, S.
- Organizer
  2017 American oil Chemist’s Society Meeting & Expo (Orland, Florida, USA)
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-17H00817
[Presentation] Identification of the active proteins in rice bran having an inhibitory activity of cholesterol micellar solubility.2016
- Author(s)
  Jilite Wang, Masaya Shimada and Satoshi Nagaoka
- Organizer
  International conference on rice bran oil (2016)
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] 茶ポリフェノール類のコレステロールミセル溶解阻害活性とその分子機構に関する研究2016
- Author(s)
  小川和樹、廣瀬紗弓、内田和宏、長岡利、柳瀬笑子
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K07427
[Presentation] Exhaustive analysis of a novel bile acid binding peptide derived from soybean protein and efficient modification of soystatin by peptide array2016
- Author(s)
  Satoshi Nagaoka
- Organizer
  The 107 th American oil Chemist’s Society Meeting & Expo
- Place of Presentation
  Salt Lake City, USA
- Year and Date
  2016-05-04
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] 脂質代謝改善ペプチド, 「食品タンパク質由来の健康機能性ペプチド研究の最先端」2016
- Author(s)
  長岡　利
- Organizer
  日本農芸化学会2016年度大会シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] ペプチドアレイによる新規コレステロール代謝改善ペプチドの探索評価と作用機構解析2016
- Author(s)
  秋江祐希、久松賢太郎、柳瀬笑子、島田昌也、長岡利
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] A novel hypocholesterolemic pentapeptide, lactostatin, inhibits cholesterol absorption via the suppression of ABCA1 gene expression in Caco-2 cells.2015
- Author(s)
  Yuji Sakai, Akemi Komuro, Masaya Shimada, Satoshi Nagaoka
- Organizer
  Asian Congress of Nutrition 2015
- Place of Presentation
  横浜
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] 大豆β-コングリシニン α' サブユニット由来ペプチドのコレステロール代謝改善作用2015
- Author(s)
  山本仁美、金　梨援、島田昌也、長岡　利
- Organizer
  第69回日本栄養・食糧学会中部支部大会
- Place of Presentation
  静岡
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] ラクトスタチンの媒介する新規腸コレステロール吸収調節系の解析2015
- Author(s)
  酒井優治、小室あゆ美、山本達記、島田昌也、長岡利
- Organizer
  平成27年度酪農科学シンポジウム
- Place of Presentation
  帯広
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] Cholesterol lowering peptides and polyphenols, ”Developing New Research Excellence in Natural Science and Technology”, 2015,2015
- Author(s)
  Satoshi Nagaoka
- Organizer
  The 1st GU-NAST International Joint Meeting (GU-NAST 2015)
- Place of Presentation
  Gifu
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] エピガロカテキンガレートはAnnexin A2非依存的にLDL受容体の増加及びPCSK9の低下を誘導する2015
- Author(s)
  北村幸平, 三島周平, 岡田雄大, 島田昌也, 長岡利
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25660100
[Presentation] 大豆由来ペプチドVVFLASVSは疎水性相互作用を介してコレステロールのミセル溶解性を低下させる.2015
- Author(s)
  久松賢太郎, 秋江祐希, 島田昌也, 岩本悟志, 長岡利
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] ラクトスタチンはHNF-3alpha及びカルシウムシグナルを介してコレステロール分解系を活性化する.2015
- Author(s)
  磯貝渚, 古田真優, 島田昌也, 長岡利
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] Cholesterol-lowering peptides2015
- Author(s)
  Satoshi Nagaoka
- Organizer
  Asian Congress of Nutrition 2015
- Place of Presentation
  横浜
- Year and Date
  2015-05-16
- Invited
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] Epigallocatechin gallate and quercetin induce a suppression of PCSK9 accompanying with an up-regulation of LDL receptor in HepG2 cells.2014
- Author(s)
  Nagaoka, S., Kitamura, K., Mishima, S. and Shimada, M.
- Organizer
  The 27th International Conference on Polyphenols
- Place of Presentation
  名古屋
- Year and Date
  2014-09-02
- Data Source
  KAKENHI-PROJECT-25660100
[Presentation] Hypocholesterolemic and anti-obesity actions of novel food components.2014
- Author(s)
  Satoshi Nagaoka
- Organizer
  Frontiers in Chemical Sciences 2014
- Place of Presentation
  インド
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] Epigallocatechin gallateはPCSK9低下を伴ってLDL受容体を活性化する2014
- Author(s)
  北村幸平, 三島周平, 岡田雄大, 島田昌也, 長岡利
- Organizer
  第8回日本ポリフェノール学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-25660100
[Presentation] IIAEKはHNF-3α及びカルシウムシグナリングを介してコレステロール分解系を活性化する.2014
- Author(s)
  古田真優, 磯貝渚, 井辰かおる, 世古聖士, 島田昌也, 長岡利
- Organizer
  日本アミノ酸学会第8回学術大会
- Place of Presentation
  東京
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] 新規コレステロール吸収抑制ペプチドVVFLASVSのコレステロールミセルに対する影響.2014
- Author(s)
  久松賢太郎, 秋江祐希, 島田昌也, 岩本悟志, 長岡利
- Organizer
  第67回日本栄養・食糧学会中部支部大会
- Place of Presentation
  静岡
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26292067
[Presentation] 生活習慣病予防改善ペプチドの特定・網羅解析・作用機構解析・高機能化戦略2013
- Author(s)
  長岡利
- Organizer
  BIO tech 2013 講演
- Place of Presentation
  東京
- Year and Date
  2013-05-03
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] 脂質代謝改善ペプチド,日本栄養食糧学会シンポジウム講演2013
- Author(s)
  長岡利
- Organizer
  第67回日本栄養・食糧学会大会講演要旨集p.122
- Place of Presentation
  名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] 食品由来ペプチド・タンパク質とコレステロール代謝2013
- Author(s)
  長岡利
- Organizer
  第25回夏期油脂・コレステロール研究会講演
- Place of Presentation
  松山
- Year and Date
  2013-07-20
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ラクトスタチンの媒介する新規腸コレステロール吸収調節系の解析2013
- Author(s)
  山本達記, 小室あゆ美, 木地裕美, 大畑愛美, 島田昌也, 長岡利
- Organizer
  平成25年度酪農科学シンポジウム要旨集p.24
- Place of Presentation
  岡山
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ラクトスタチンはABCA1 発現低下を介してコレステロール吸収を抑制する2013
- Author(s)
  小室あゆ美, 山本達記, 木地裕美, 大畑愛美, 島田昌也, 長岡利
- Organizer
  日本農芸化学会中部支部第168回例会講演要旨集p.33
- Place of Presentation
  名古屋
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ラクトスタチンの媒介する新規腸コレステロール吸収調節系の解析2013
- Author(s)
  山本達記, 小室あゆ美, 木地裕美, 大畑愛美, 島田昌也, 長岡利
- Organizer
  第67回日本栄養・食糧学会大会講演要旨集p.122
- Place of Presentation
  名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ペプチドアレイによる大豆オレオシン由来新規胆汁酸結合ペプチドの網羅解析2012
- Author(s)
  長岡利, ら
- Organizer
  第66回日本栄養食糧学会
- Place of Presentation
  仙台
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ペプチドアレイによるオレオシン由来の疎水性胆汁酸結合ペプチドの網羅解析2012
- Author(s)
  長岡　利
- Organizer
  第66回日本栄養食糧学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ペプチドアレイによる大豆オレオシン由来新規胆汁酸結合ペプチドの網羅解析2012
- Author(s)
  加藤由喜奈, 柴田麗, 長岡利
- Organizer
  第66回日本栄養・食糧学会大会講演要旨集p.127
- Place of Presentation
  仙台
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ラクトスタチンはHNF3αを介してコレステロール分解系を活性化する2012
- Author(s)
  井辰かおる, 後藤剛, 長岡利
- Organizer
  日本農芸化学会2012年度大会講演要旨集3J13a15
- Place of Presentation
  京都
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ペプチドアレイによる大豆由来疎水性胆汁酸結合ペプチドの網羅解析2011
- Author(s)
  長岡利、高橋千奈, 加藤由喜奈, 小林浩子、後藤剛、加賀千晶、大河内美奈、加藤竜司、本多裕之
- Organizer
  日本栄養食糧学会第65回大会講演
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] ラクトスタチンはHNF-3αを介してコレステロール分解系を活性化する2011
- Author(s)
  井辰かおる, 世古聖士, 長岡利
- Organizer
  日本アミノ酸学会第5回学術大会講演要旨集P.72
- Place of Presentation
  名古屋
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ラクトスタチンの媒介する新規肝臓コレステロール分解調節系2011
- Author(s)
  井辰かおる、後藤剛、長岡利
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] ラクトスタチンの媒介する新規肝臓コレステロール分解調節系2011
- Author(s)
  井辰かおる, 後藤剛, 長岡利
- Organizer
  日本農芸化学会2011年度大会講演要旨集P.70
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] ペプチドアレイによる大豆由来疎水性胆汁酸結合ペプチドの網羅解析2011
- Author(s)
  長岡利, 高橋千奈, 加藤由喜奈, 小林浩子, 後藤剛, 加賀千晶, 大河内美奈, 加藤竜司, 本多裕之
- Organizer
  第65回日本栄養・食糧学会大会講演要旨集p.178
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-23380075
[Presentation] 茶カテキンのLDL受容体活性化機構2011
- Author(s)
  長岡利, ら
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-21658050
[Presentation] ペプチドアレイを活用した大豆β-コングリシニン由来新規胆汁酸結合ペプチドの網羅解析2010
- Author(s)
  高橋千奈、小林浩子、山下祐加、森川健正、加賀千晶、大河内美奈、加藤竜司、本多裕之,後藤剛、長岡利
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] 大豆β-コングリシニンαサブユニットはコレステロール代謝改善作用を発揮する2010
- Author(s)
  長岡利、見屋井大輔、高岩文雄、黒田昌治、丸山伸之、内海成
- Organizer
  日本栄養食糧学会
- Place of Presentation
  徳島
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] ラクトスタチンの媒介するコレステロール分解調節系の解析2009
- Author(s)
  世古聖士、森川健正、長岡利
- Organizer
  第63回日本栄養・食糧学会大会講演要旨集
- Place of Presentation
  長崎
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] コレステロール代謝改善ペプチド(ラクトスタチン:IIAEK)は腸管からインタクトな形で吸収される2009
- Author(s)
  長岡利、石川久純子、金丸義敬
- Organizer
  第63回日本栄養・食糧学会大会講演要旨集
- Place of Presentation
  長崎
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] 食品タンパク質由来の脂質改善ペプチド2009
- Author(s)
  長岡利
- Organizer
  第63回日本栄養・食糧学会大会シンポジウム「機能性タンパク質・ペプチドと生体利用」第63回日本栄養・食糧学会大会講演要旨集
- Place of Presentation
  長崎(招待講演)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] DNAアレイによるエラグ酸の脂質代謝改善作用機構解析2009
- Author(s)
  長岡利, ら
- Organizer
  日本栄養食糧学会中部支部会
- Place of Presentation
  名古屋大学
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-21658050
[Presentation] 食品タンパク質由来の脂質代謝改善ペプチド2009
- Author(s)
  長岡利
- Organizer
  日本栄養食糧学会
- Place of Presentation
  長崎
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] 卵白由来ペプチドによるコレステロール代謝改善作用2009
- Author(s)
  長岡利
- Organizer
  日本農芸化学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-20380075
[Presentation] エピガロカテキンガレートによるLDL受容体活性化及びPCSK9減少の分子機構
- Author(s)
  北村幸平、三島周平、島田昌也、長岡利
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学
- Data Source
  KAKENHI-PROJECT-25660100
[Presentation] A novel hypocholesterolemic pentapeptide, lactostatin, inhibits cholesterol absorption via the suppression of ABCA1 gene expression in Caco-2 cells.
- Author(s)
  長岡　利
- Organizer
  第105回アメリカ油化学会年会
- Place of Presentation
  アメリカ（サンアントニオ）
- Invited
- Data Source
  KAKENHI-PROJECT-23380075

1. EBINA Takusaburo (60004678)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. KANAMARU Yoshihiro (50111795)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. SEISHIMA Mitsuru (10171315)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. HONDA Hiroyuki (70209328)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. YANASE Emiko (60313912)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. KENII Watanabe (70023447)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MAKOTO Shimoyamada (60235695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MINAMOTO Nobuyuki (10144007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 上野義仁 (20250467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KATOU Ryuji (50377884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 島田昌也 (10576755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. 松井利郎 (20238942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 伊藤弘康 (80373075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 谷口正之 (00163634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 落合秋人 (40588266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KODAMA Yoshikatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKASABURO Ebina

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nagaoka Satoshi 長岡 利

NAGAOKA Satoshi 長岡 利

Research Projects

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Co-Researchers

Exploring of functional peptides from edible proteins and establishment of oral administration without activity lossOngoing

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ウーロン茶の生理機能発現メカニズム解析を指向した高分子ポリフェノールの構造研究Ongoing

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Fundamental study on the lipid lowering peptides derived from food proteinsPrincipal InvestigatorOngoing

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Discovery of Innovative lipid lowering peptides by targetting the bio-molecule and Creation of novel screening technologyPrincipal Investigator

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The clarification and application of a novel regulatory mechanism of cholesterol metabolism mediated by polyphenols.Principal Investigator

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Identification, exhaustive analysis, clarification of action mechanism and efficient modification of novel hypolipidemic peptidesPrincipal Investigator

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ポリフェノールの脂質代謝改善作用に関与する新規情報伝達系の解明Principal Investigator

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The clarification and application of mechanism of hypocholesterolemic peptides by peptide arrayPrincipal Investigator

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ポリフェノールの媒介する新しい情報伝達機構の解明と細胞機能Principal Investigator

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ラクトスタチンの媒介する新規コレステロール代謝調節系の解明Principal Investigator

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Mechanism of action of new hypocholesterolemic pentapeptideiPrincipal Investigator

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Nagaoka Satoshi 長岡利

NAGAOKA Satoshi 長岡利