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NAOE Tomoki  直江 知樹

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直江 知樹  ナオエ トモキ

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Researcher Number 50217634
Other IDs
Affiliation (Current) 2025: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 院長
Affiliation (based on the past Project Information) *help 2014 – 2015: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 院長
2013 – 2014: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他
2013: 名古屋医療センター, 血液内科, 院長
2011 – 2012: 名古屋大学, 医学(系)研究科(研究院), 教授
2011 – 2012: 名古屋大学, 医学系研究科, 教授 … More
2007 – 2010: Nagoya University, 大学院・医学系研究科, 教授
2005 – 2006: 名古屋大学, 大学院医学系研究科, 教授
2002 – 2005: Nagoya University, Graduate school of Medicine Professor, 大学院・医学系研究科, 教授
2001: Graduate School of medicinej, Nagoya University Professor, 大学院・医学研究科, 教授
1994 – 2000: 名古屋大学, 医学部, 助教授
1992 – 1993: 名古屋大学, 医学部, 講師
1989 – 1991: 名古屋大学, 医学部, 助手
1986: Nagoya University school of medicine Fellow, 医学部, 医員 Less
Review Section/Research Field
Principal Investigator
Hematology / Hematology / Biological Sciences / 老化(加齢)
Except Principal Investigator
Hematology / Hematology / Pediatrics / Biological Sciences
Keywords
Principal Investigator
白血病 / FLT3 / シグナル伝達 / 急性前骨髄球性白血病 / キナーゼ阻害剤 / 分子標的治療 / leukemia / JAK3 / JAK2 / caspase 8 … More / トランスレーショナルリサーチ / 癌 / 耐性 / 幹細胞 / 免疫不全マウス / 分子標的療法 / アポトーシス / チロシンキナーゼ / 染色体転座 / 治療関連二次性白血病 / 急性リンパ性白血病 / surrogate marker / target therapy / cell signaling / 発現クローニング法 / 変異 / ヌクレオフォスミン / 造血器腫瘍 / サロゲートマーカー / 標的治療 / Molecularly targeted thrapy / transgenic mouse / Leukemia / 変異FLT3 / 骨髄移植モデル / トランスジェニックマウス / AsィイD22ィエD2OィイD23ィエD2 / apoptosis / レドックス / 亜ヒ素酸 / 急性前骨髄性白血病 / caspase-8 / As_< 2> O_< 3> / As_2O_3 / 白血球 / 標準治療 / 酸化ストレス / PDX / 悪性リンパ腫 / 微小環境 / 薬剤スクリーニング / 中鎖脂肪酸誘導体 / pyruvinium pamoate / STAT3/5阻害剤 / 分子標的剤 / FLT3阻害剤 / FLT3 / STAT5 / STAT3 / がん薬物治療 / 残存 / ニッシェ / ホーミング / 接着 / 造血ニッチ / 化学療法 / 治療法 / 転写抑制 / キメラ転写物 / 転写抑制複合体 / PML-RARα / 急性前骨髓球性白血病 / マウスモデル / STAT / キメラ転写因子 / メチル化 / 遺伝子変異 / トランスインフォメーション / TEL / histone deacetylase / kinase inhibitor / PML-RARalfa / tandem duplication / 転座メカニズム / 残存腫瘍 / mutation / 抗体サブクラス / B細胞分化 / CDR-III / B細胞レパトアー / 加齢 / 免疫グロブリン重鎖(IgH)遺伝子 / 治療効果 / PCR / 超可変部遺伝子 / 免疫グログリン / 遺伝子マーカー / 微量残存腫瘍 … More
Except Principal Investigator
FLT3 / 急性前骨髄球性白血病 / 分化誘導療法 / レチノイン酸 / Am-80 / leukemia / チロシンキナーゼ / 急性白血病 / PML / 白血病 / PI3K / BMI-1 / JMML / tandem duplication / SYK / CEV / SEREX / GVL / matched-pair analysis / JALSG / acute promyelocytic leukemia / アポトーシス / As_2O_3 / all-trans retinoic acid / 造血幹細胞 / MDR1 / ケモカイン / 分子標的療法 / レチノイドアンタゴニスト / 細胞内レチノイン酸結合蛋白 / 分子生物学 / PML遺伝子 / RAR遺伝子 / 急性リンパ性白血病 / Platelet abnormality / GPIIb-IIIa / Platelet membrane molecules / Platelets / アミノ酸配列 / 血小板異常症 / モノクローナル抗体 / 【III】a / GP【II】b / 血小板膜蛋白分子 / 血小板 / extracellular matrix / cell adhesion / tyrosine kinase / integrin / JNK / PI3キナーゼ / P13K / 細胞外マトリックス / 細胞接着 / インテグリン / Mouse model / Apoptosis / Proliferation / Differentiation / マウス移植モデル / 増殖 / 分化 / T cell / Aplastic Anemia / NOG mice / G-CSF / 7モノソミー / T細胞 / 再生不良性貧血 / NOGマウス / genetic mutation / molecular target therapy / tyrosinekinase / 遺伝子変異 / Tyrosine kinase / point mutation / 点突然変異 / trandem duplication / DNA Vaccine / Gene Gun / Vaccine / SFV / DC / デンドリマー / マンノース / チロシンリン酸化 / PDGFR / DNAワクチン / 遺伝子銃 / ワクチン / meta-analysis / differentiation therapy / bone marrow transplantation / chemotherapy / acute leukemia / MRC / IBMTR / メタアナリス / 急性骨髄性白血病 / メタアナリシス / マッチドペアアナリシス / 骨髄移植療法 / 化学療法 / cytoplasmic retinoic acid binding protein / retinoid / apoptosis / Vitamin A / 癌瘍1号-713 / PML-RARαキメラ遺伝子 / Phenotypic change / Drug resistance / Retroviral vector / Hematopoietic stem cells / P-glycoprotin / Multidrug resistant gene / Gene transfection / PSVLベクタ- / CFU / 骨髄幹細胞 / mdr / 形質転換 / 形貭転換 / 薬剤耐性 / レトロウイルスベクタ- / Pー糖蛋白 / 多剤耐性遺伝子 / 遺伝子導入 / 白血病ニッチェ / 腫瘍微小環境 / 血液学 / ニッチェ / 血液悪性腫瘍幹細胞 / 血液腫瘍学 / FK228 / ヒストンデアセチラーゼ(HDAC) / ガングリオシドGD2 / CD25抗体 / CEA / 抗c-kit / ウィルス発癌 / 抗ケモカインレセプター抗体 / FLT3遺伝子 / 抗ガングリオシド抗体 / リモデリング / ケモカインCCR4 / ヒト化抗体 / 抗変異EGFレセプター抗体(3C10) / IRF4 / ガングリオシドGD2抗体 / ハイリスクgenotype / translation research / 抗体 / MUM1 / 肝炎ウイルス / 抗体リモデリング / ガングリオシド / 前臨床試験 / 抗体療法 / 亜砒酸 / RARA / トランスジェニック・マウス / ユビキチン・プロテアゾーム / ブファリン / ポリプレン酸 / レチノイン酸レセプター / レチノイド / 分子誘導療法 / 急性前骨髄性白血病 / レチノイン酸受容体 / 分子マ-カ- / CDR3 / 微量残存腫瘍 / 免疫グロブリン遺伝子 / cALL Less
  • Research Projects

    (33 results)
  • Research Products

    (186 results)
  • Co-Researchers

    (59 People)
  •  Translational research toward drug discovery of leukemiaPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Hospital Organization Nagoya Medical Center
  •  Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cellsPrincipal Investigator

    • Principal Investigator
      NAOE TOMOKI
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      National Hospital Organization Nagoya Medical Center
  •  Effects of FGF2 on the leukemia microenvironment in the bone marrow

    • Principal Investigator
      NAKAYAMA Takayuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Aichi Medical University
      Nagoya University
  •  Development of innovative anti-tumor agents that target signal transducers and activator of transcriptionPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Basic research aimed at understanding and overcoming of the primary and secondary resistance in molecular target therapyPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Molecular mechanisms and therapeutic approach of residual leukemiaPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Research & Development of molecular target therapy for leukemia and Its assessment SystemPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
  •  Crosstalk of FLT3 and integrin signal transduction pathway in acute myeloid leukemia

    • Principal Investigator
      KATSUMI Akira
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Analysis of aberrant signal tansduction in hematological malignancy and development of treatment methods.Principal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Role of BMI-1 in leukemia

    • Principal Investigator
      YAMAMOTO Kauzhito
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Aichi Cancer Center
      Nagoya University
  •  Effect of G-CSF on hematopoietic stem cells derived from aplastic anemia patients in NOD/SCID/γc^<null> mice

    • Principal Investigator
      KOJIMA Seiji
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nagoya University
  •  白血病に選択性を有する分子標的治療法ならびにその評価法の開発Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya University
  •  Basic investigation for the development of a novel anti-leukemic therapy targeting to the mutant FLT3 molecule.

    • Principal Investigator
      KIYOI Hitoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Establishment of a leukemia model mouse by introducing mutated FLT3 genePrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  抗体療法及びがんの前臨床試験研究

    • Principal Investigator
      上田 龍三
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagoya City University
  •  Analysis of the deregulation mechanism on cell growth and differentiation induced by mutant ELT3

    • Principal Investigator
      KIYOI Hitoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Novel immunotherapy for Hematological Malignancy

    • Principal Investigator
      SAITO Hidehiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  白血病進展に関与する異常FLT3分子の標的分子群の解析Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya University
  •  Involvement of Fas ligand-independent caspase8 activation in AsィイD22ィエD2OィイD23ィエD2-induced apoptosisPrincipal Investigator

    • Principal Investigator
      NAOE Tomoki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  白血病に関わる染色体転座部位の構造解析による転座メカニズム研究Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Collaborative study for the best treatment of acute leukemia.

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Hematology
    • Research Institution
      Hamamatsu University School of Medicine
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  治療関連二次性白血病の発症にかかわる染色体転座機構の研究Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  マルチパラメーターによる微量残存白血病の同定とその臨床意義の検討Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  加齢にともなうB細胞免疫グロブリン遺伝子レパトアーの変遷Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Nagoya University
  •  Differentiation therapy of acute promylocytic leukemia.

    • Principal Investigator
      OHNO Ryuzo, 大野 龍三
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Hamamatsu Univ.
  •  遺伝子マーカーを指標にした微量残存腫瘍の高感度検出と治療効果の新評価法Principal Investigator

    • Principal Investigator
      直江 知樹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  レチノイン酸による白血病の分化誘導療法と分化機構の分子生物学的解明

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  免疫遺伝子超可変部をマ-カとした2ステップPCR法による微量残存腫瘍の検出

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  Transfection of Multidrug Resistant Gene into Human Hematopoietic Stem Cells and its Clinical Application in Bone Marrow Transplantation

    • Principal Investigator
      OHNO Ryuzo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagoya University
  •  Molecular analysis of platelet membrane protein abnormality

    • Principal Investigator
      SHIKU Hiroshi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagasaki University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 造血器腫瘍取り扱い規約2010

    • Author(s)
      直江知樹, 他
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Book] 造血器腫瘍取り扱い規約2010

    • Author(s)
      直江知樹 他
    • Total Pages
      265
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] BLNK is a selective target of repression by PAX5-PML in the differentiation block that leads to the development of acute lymphoblastic leukemia.2016

    • Author(s)
      Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 9 Pages: 4723-31

    • DOI

      10.1074/jbc.m115.637835

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09492, KAKENHI-PROJECT-25293218
  • [Journal Article] Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells.2016

    • Author(s)
      Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T
    • Journal Title

      Leukemia and lymphoma

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Journal Article] Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells2015

    • Author(s)
      Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 13054-13054

    • DOI

      10.1038/srep13054

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09473, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-25670101, KAKENHI-PROJECT-25293218
  • [Journal Article] Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells.2015

    • Author(s)
      Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
    • Journal Title

      J Immunol

      Volume: 194(3) Pages: 911-920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Journal Article] Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoforms expression profile mediated by bcr-abl in chronic myeloid leukemia.2015

    • Author(s)
      Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.
    • Journal Title

      Cancer Letters

      Volume: 360 Issue: 1 Pages: 28-38

    • DOI

      10.1016/j.canlet.2015.01.039

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-25462003
  • [Journal Article] Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells.2015

    • Author(s)
      Shinohara H, Kumazaki M, Minami Y, Ito Y, Sugito N, Kuranaga Y, Taniguchi K, Yamada N, Otsuki Y, Naoe T, Akao Y
    • Journal Title

      Cancer Letters

      Volume: 371 Issue: 1 Pages: 1-11

    • DOI

      10.1016/j.canlet.2015.11.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-16K10482
  • [Journal Article] Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells.2015

    • Author(s)
      Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
    • Journal Title

      J Immunol

      Volume: 194(3) Pages: 911-920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Journal Article] Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients2014

    • Author(s)
      Kihara R, S. Ogawa, S. (32/33) Naoe, T.
    • Journal Title

      Leukemia

      Volume: inpress Issue: 8 Pages: 1586-95

    • DOI

      10.1038/leu.2014.55

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-24590688, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-26461431
  • [Journal Article] Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions2014

    • Author(s)
      Satoshi Nishiwaki, Takayuki Nakayama, Makoto Murata, Tetsuya Nishida, Seitaro Terakura, Shigeki Saito, Tomonori Kato, Hiroki Mizuno, Nobuhiko Imahashi, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Masafumi Ito, Kyosuke Takeshita, Hidefumi Kato, Shinya Toyokuni, Keisuke Nagao, Ryuzo Ueda, and Tomoki Naoe
    • Journal Title

      PLOS one

      Volume: 9(5) Issue: 5 Pages: e96252-e96252

    • DOI

      10.1371/journal.pone.0096252

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591382, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24790969, KAKENHI-PROJECT-26461435
  • [Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014

    • Author(s)
      Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
    • Journal Title

      Blood Cancer J

      Volume: 4

    • NAID

      120006987091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014

    • Author(s)
      Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
    • Journal Title

      Blood Cancer J

      Volume: 4

    • NAID

      120006987091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014

    • Author(s)
      Hayakawa F, Tomita A, Naoe T
    • Journal Title

      Rinsho Ketsueki

      Volume: 55(4) Pages: 445-449

    • NAID

      130004920671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014

    • Author(s)
      Hayakawa F, Tomita A, Naoe T
    • Journal Title

      Rinsho Ketsueki

      Volume: 55(4) Pages: 445-449

    • NAID

      130004920671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Journal Article] Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia Jurkat cells by modulating the expression of Fas-associated protein with death domain (FADD).2014

    • Author(s)
      Yamada N, Noguchi S, Kumazaki M, Shinohara H, Miki K, Naoe T, Akao Y.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1843(3) Pages: 590-602

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Journal Article] De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: Molecular mechanisms and correlation with rituximab sensitivity.2014

    • Author(s)
      Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 1 Pages: 35-43

    • DOI

      10.1111/cas.12307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-24591388, KAKENHI-PROJECT-25670449
  • [Journal Article] A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases2013

    • Author(s)
      Fumihiko Hayakawa, Keiki Sugimoto, Yasuo Harada, Norikazu Hashimoto, Naoto Ohi, Shingo Kurahashi, Tomoki Naoe
    • Journal Title

      Blood Cancer Journal

      Volume: 3 Issue: 11 Pages: e166-e166

    • DOI

      10.1038/bcj.2013.63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591381, KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218
  • [Journal Article] Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice.2013

    • Author(s)
      Kiyoko Yamamoto, Shinobu Tsuzuki, Yosuke Minami, Yukiya Yamamoto, Akihiro Abe, Koichi Ohshima, Masao Seto, Tomoki Naoe.
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 9 Pages: e74864-e74864

    • DOI

      10.1371/journal.pone.0074864

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591410, KAKENHI-PROJECT-24390249, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-25461437, KAKENHI-PROJECT-25670449
  • [Journal Article] MiR-145 attenuates intracellular translocation of β-catenin by targeting catenin δ-1 in colon cancer cells.2013

    • Author(s)
      Yamada N., Noguchi S., Mor i T., Naoe T., Maruo K. and Akao Y.
    • Journal Title

      Cancer Letters

      Volume: 335 Issue: 2 Pages: 332-342

    • DOI

      10.1016/j.canlet.2013.02.060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J00639, KAKENHI-PROJECT-25293218
  • [Journal Article] Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.2013

    • Author(s)
      Ando K
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Issue: 13 Pages: 9457-9467

    • DOI

      10.1074/jbc.m112.415703

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591040, KAKENHI-PROJECT-22591065, KAKENHI-PROJECT-23590829, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-25293218
  • [Journal Article] Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia.2013

    • Author(s)
      Katagiri S, Minami Y, Naoe T, et al.
    • Journal Title

      Clin Cancer Res.

      Volume: 19 Issue: 6 Pages: 1422-1432

    • DOI

      10.1158/1078-0432.ccr-12-1777

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-23501312, KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PROJECT-25461412, KAKENHI-PUBLICLY-23112507
  • [Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome.2012

    • Author(s)
      Iriyama C, Tomita A, Hoshino H,Adachi-Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 662-669

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.2012

    • Author(s)
      Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
    • Journal Title

      J Immunol.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation2012

    • Author(s)
      Takahiko Yasuda, Fumihiko Hayakawa, Shingo Kurahashi, Keiki Sugimoto , Yosuke Minami, Akihiro Tomita, Tomoki Naoe
    • Journal Title

      Journal of Immunology

      Volume: 188 Issue: 12 Pages: 6127-34

    • DOI

      10.4049/jimmunol.1103039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591381, KAKENHI-PROJECT-23659487, KAKENHI-PROJECT-24591388
  • [Journal Article] Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan2012

    • Author(s)
      Tokunaga T, Shi mada K, Yamamoto K, Chihara D, Ichihashi T, Oshima R, Tanimoto M, Iwasaki T, Isoda A, Sakai A, Kobayashi H, Kitamura K, Matsue K, Taniwaki M, Tamashima S, Saburi Y, Masunari T, Naoe T, Nakamura S, Kinoshita T
    • Journal Title

      Blood

      Volume: 119 Pages: 2837-2843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation : macrophage-targeted steroid therapy2012

    • Author(s)
      西脇聡史
    • Journal Title

      International Journal of Hematology

      Volume: (Epub ahead of print) Issue: 4 Pages: 428-33

    • DOI

      10.1007/s12185-012-1023-z

    • NAID

      10030632677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04711, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23591415
  • [Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-7372012

    • Author(s)
      Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T
    • Journal Title

      Exp Hematol

      Volume: 40 Pages: 724-737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012

    • Author(s)
      Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Yamamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T.
    • Journal Title

      Leukemia

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib2012

    • Author(s)
      Mizuno H, Nakayama T, Miyata Y, Saito S, Nishiwaki S, Nakao N, Takeshita K, Naoe T
    • Journal Title

      Leukemia

      Volume: 26 Pages: 2269-2276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-7372012

    • Author(s)
      Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.
    • Journal Title

      Exp Hematol

      Volume: 40 Pages: 724-737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012

    • Author(s)
      Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Ymamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T
    • Journal Title

      Leukemia

      Volume: 26 Pages: 2142-2143

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012

    • Author(s)
      Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Ymamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T.
    • Journal Title

      Leukemia

      Volume: 26 Issue: 9 Pages: 2142-2143

    • DOI

      10.1038/leu.2012.73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin2012

    • Author(s)
      Tomohiro Kajiguchi
    • Journal Title

      Eur J Haematol

      Volume: (in press) Issue: 4 Pages: 314-320

    • DOI

      10.1111/j.1600-0609.2011.01738.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591198, KAKENHI-PROJECT-21591199, KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-24591416
  • [Journal Article] B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation2012

    • Author(s)
      Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
    • Journal Title

      J Immunol.

      Volume: 188 Pages: 6127-6134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin.2012

    • Author(s)
      Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T
    • Journal Title

      Eur J Haematol

      Volume: 88 Pages: 314-320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737.2012

    • Author(s)
      Shimada K, Tomita A, Minami Y, Kiyoi H, Naoe T et al.
    • Journal Title

      Exp Hematol.

      Volume: 40 Issue: 9 Pages: 724-737

    • DOI

      10.1016/j.exphem.2012.05.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-23659487, KAKENHI-PROJECT-24591387
  • [Journal Article] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib2012

    • Author(s)
      水野 紘樹
    • Journal Title

      Leukemia

      Volume: 26 Issue: 10 Pages: 2269-2269

    • DOI

      10.1038/leu.2012.81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790907, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23659487
  • [Journal Article] B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation.2012

    • Author(s)
      Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
    • Journal Title

      J Immunol

      Volume: 188 Pages: 6127-6134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis.2012

    • Author(s)
      Nishiwaki S
    • Journal Title

      Int J Hematol.

      Volume: 96(3) Issue: 3 Pages: 295-300

    • DOI

      10.1007/s12185-012-1140-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590887, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23591415
  • [Journal Article] Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycine-induced lung damage2011

    • Author(s)
      斎藤繁紀
    • Journal Title

      The American Journal of Pathology

      Volume: 179 Issue: 3 Pages: 1088-1094

    • DOI

      10.1016/j.ajpath.2011.05.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04711, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23659431
  • [Journal Article] The mTOR inhibitor, everolimus(RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011

    • Author(s)
      Kuwatsuka Y, Naoe T, et al
    • Journal Title

      Blood Cancer Journal

      Volume: 1 Issue: 5 Pages: 1-7

    • DOI

      10.1038/bcj.2011.16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-22790908, KAKENHI-PROJECT-23591381
  • [Journal Article] Japan Adult Leukemia Study Group. BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.2011

    • Author(s)
      Ono T, Miyawaki S, Kimura F, Kanamori H, Ohtake S, Kitamura K, Fujita H, Sugiura I, Usuki K, Emi N, Tamaki S, Aoyama Y, Kaya H, Naoe T, Tadokoro K, Yamaguchi T, Ohno R, Ohnishi K
    • Journal Title

      Leuk Res

      Volume: 35 Pages: 598-603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Mesenchymal stem cells stably transduced with a dominant negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage.2011

    • Author(s)
      Saito S, Nakayama T*, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T
    • Journal Title

      Am J Pathol.

      Volume: 179 Pages: 1088-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. Oncogene2011

    • Author(s)
      Kurahashi S, Naoe T, et al
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1822-1830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment.2011

    • Author(s)
      Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T
    • Journal Title

      Blood

      Volume: 118 Pages: 1600-1609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment2011

    • Author(s)
      Goto E, Naoe T, et al
    • Journal Title

      Blood

      Volume: 118 Pages: 1600-1609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistanceto imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011

    • Author(s)
      Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T
    • Journal Title

      Blood Cancer J

      Volume: 1(5)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis2011

    • Author(s)
      Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y,Ishikawa K, Kaneda N, Naoe T, Kiyoi H
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 237-242

    • NAID

      10029533322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2011

    • Author(s)
      Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1822-1830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment2011

    • Author(s)
      Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T
    • Journal Title

      Blood

      Volume: 118 Pages: 1600-1609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2011

    • Author(s)
      Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1822-1830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Japan Adult Leukemia Study Group. BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay2011

    • Author(s)
      Ono T, Naoe T, et al
    • Journal Title

      Leuk Res

      Volume: 35 Pages: 598-603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.2011

    • Author(s)
      Ono T, Naoe T, et al.
    • Journal Title

      Leuk Res.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistanceto imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011

    • Author(s)
      Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T.
    • Journal Title

      Blood Cancer J

      Volume: 1(5)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.2011

    • Author(s)
      Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T.
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1822-1830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] AX5-PML acts as a dual dominant-negative form of both PAX 5 and PML.2011

    • Author(s)
      Kurahashi S, Naoe T, et al.
    • Journal Title

      Oncogene

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment2010

    • Author(s)
      Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T
    • Journal Title

      Int J Hematol

      Volume: 92 Pages: 664-666

    • NAID

      10027674164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.2010

    • Author(s)
      Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2186-2192

    • NAID

      10027832450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB42010

    • Author(s)
      Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T
    • Journal Title

      Eur J Haematol 84

      Pages: 229-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB42010

    • Author(s)
      Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T
    • Journal Title

      Eur J Haematol 84

      Pages: 229-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia2010

    • Author(s)
      Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T
    • Journal Title

      Int J Hematol

      Volume: 92 Pages: 624-633

    • NAID

      10027673999

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : a renort from the BINGO study.2010

    • Author(s)
      Ishikawa Y, Naoe T, et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 2186-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Journal Article] KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation2009

    • Author(s)
      Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.
    • Journal Title

      Blood. 114

      Pages: 1607-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Circumventing resistance to imatinib therapy in chronic myeloid leukemia2009

    • Author(s)
      Minami Y, Naoe T
    • Journal Title

      Gan To Kagaku Ryoho 36(4)

      Pages: 544-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] rrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2R gammac mice2009

    • Author(s)
      Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T
    • Journal Title

      Cancer Sci (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines2009

    • Author(s)
      Furuhata A, Murakami M, Ito H, Gao S, Yoshida K, Sobue S, Kikuchi R, Iwasaki T, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T.
    • Journal Title

      Leukemia. 23

      Pages: 1270-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] GATA-1 and GATA-2 binding to 3'enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines.2009

    • Author(s)
      Furuhata A, Naoe T, et al
    • Journal Title

      Leukemia. 12(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia2009

    • Author(s)
      Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.
    • Journal Title

      Eur J Haematol 83

      Pages: 90-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation2009

    • Author(s)
      Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T
    • Journal Title

      Blood 114

      Pages: 1607-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy2008

    • Author(s)
      Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T
    • Journal Title

      Int J Hematol 88

      Pages: 471-5

    • NAID

      10023971017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Prognostic implication and biological roles of RhoH in acute myeloid leukaemia2008

    • Author(s)
      Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T
    • Journal Title

      Eur J Haematol 81

      Pages: 454-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008

    • Author(s)
      Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY
    • Journal Title

      Proc Natl Acad Sci U S A 105

      Pages: 17967-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome2008

    • Author(s)
      Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.
    • Journal Title

      Br J Haematol. 140

      Pages: 394-401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008

    • Author(s)
      Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY.
    • Journal Title

      Proc Natl Acad Sci U S A 105

      Pages: 17967-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Abnormal cytoplasmic dyslocalisation and/or reduction of nucle ophosmin protein level rarely occurs in myelodysplastic syndromes.2008

    • Author(s)
      Ishikawa Y, Naoe T, et al
    • Journal Title

      Leuk Lymphoma. 49

      Pages: 2359-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis2008

    • Author(s)
      Hayakawa F, Naoe T, et.al.
    • Journal Title

      J Biol Chem. 283

      Pages: 24420-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy.2008

    • Author(s)
      Abe A, Naoe T, et al
    • Journal Title

      Int J Hematol. 88

      Pages: 471-5

    • NAID

      10023971017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy2008

    • Author(s)
      Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.
    • Journal Title

      Int J Hematol. 88

      Pages: 471-5

    • NAID

      10023971017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Prognostic implication and biological roles of RhoH in acute myeloid leukaemia2008

    • Author(s)
      Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.
    • Journal Title

      Eur J Haematol 81

      Pages: 454-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008

    • Author(s)
      Minami Y and Naoe T, et.al.
    • Journal Title

      Proc Natl Acad Sci USA. 105

      Pages: 17967-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors2008

    • Author(s)
      Ishida H and Naoe T, et.al.
    • Journal Title

      Bioorg Med Chem Lett. 18

      Pages: 5472-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Mutational analysis of SOS1 gene in acute myeloid leukemia2008

    • Author(s)
      Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T
    • Journal Title

      Int J Hematol 88

      Pages: 460-2

    • NAID

      10023970986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)2007

    • Author(s)
      Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T
    • Journal Title

      Eur J Haematol 79

      Pages: 25-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD2007

    • Author(s)
      Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.
    • Journal Title

      Leukemia 21

      Pages: 403-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice2007

    • Author(s)
      Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T
    • Journal Title

      Leukemia 21

      Pages: 136-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Journal Article] LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)2007

    • Author(s)
      Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.
    • Journal Title

      Eur J Haematol. 79

      Pages: 25-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU. 1-induced C/EBPepsilon expression in myeloid differentiation2007

    • Author(s)
      Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
    • Journal Title

      Mol Cell Biol 27

      Pages: 5819-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults2007

    • Author(s)
      Kiyoi H, Yamaji S, Kojima S, Naoe T.
    • Journal Title

      Leukemia 21

      Pages: 574-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells2007

    • Author(s)
      Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.
    • Journal Title

      Leukemia 21

      Pages: 2476-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.2007

    • Author(s)
      Ninomiya M, Abe A, Katsumi A. Naoe T et al.
    • Journal Title

      Leukemia. 21(1)

      Pages: 136-142

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice2007

    • Author(s)
      Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.
    • Journal Title

      Leukemia 21

      Pages: 136-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations2007

    • Author(s)
      Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Shimizu M, Arai H, Ishii K, Akinaga S, Naoe T.
    • Journal Title

      Clin Cancer Res. 13(15Pt1)

      Pages: 4575-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication2006

    • Author(s)
      Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.
    • Journal Title

      Int J Hematol 84

      Pages: 328-36

    • NAID

      10019259671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation.2006

    • Author(s)
      Adachi T, Matsushita T, Ichihashi R, Hirashima K, Ito M, Inukai A, Yokozawa T, Nishida T, Murata M, Hayashi M, Katsumi A. Kojima T, Saito H, Naoe T.
    • Journal Title

      Int J Hematol. 83(5)

      Pages: 415-9

    • NAID

      10018141145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Japan Adult Leukemia Study Group. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group2006

    • Author(s)
      Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, Kobayashi T, Ueda Y, Takeuchi M, Miyawaki S, Maruta A, Emi N, Miyazaki Y, Ohtake S, Jinnai I, Matsuo K, Naoe T, Ohno R
    • Journal Title

      J Clin Oncol. 24

      Pages: 460-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Recurrent intramural hematoma of small intestine in a severe hemophilia A patient with high titer of factor VIII inhibitor. A case report and a review of the literatures.2006

    • Author(s)
      Katsumi A Matsushita T, Hiroshima K, Iwasaki T, Adachi T, Yamamoto K, Kojima T, Takamatsu J, Saito H, Naoe T.
    • Journal Title

      Int J.Hematol. 84(2)

      Pages: 166-9

    • NAID

      10019284929

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Establishment of Stroma Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2 with FLT3 Tandem Duplication.2006

    • Author(s)
      Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A. Emi N, Naoe T.
    • Journal Title

      Int J.Hematol. 84(4)

      Pages: 328-36

    • NAID

      10019259671

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo2006

    • Author(s)
      Atsumi A, Tomita A, Kiyoi H, Naoe T.
    • Journal Title

      Biochem Biophys Res Commun. 345

      Pages: 1471-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice. _2006

    • Author(s)
      Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T.
    • Journal Title

      J Thromb Haemost. 4(1)

      Pages: 177-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia2006

    • Author(s)
      Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.
    • Journal Title

      Leuk Res. 30

      Pages: 1085-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation2006

    • Author(s)
      Kiyoi H, Naoe T.
    • Journal Title

      Int J Hematol 83

      Pages: 301-8

    • NAID

      10017475435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Identification of amino acid residues essential for heparin binding by the Al domain of human von Willebrand factor.2006

    • Author(s)
      Adachi T, Matsushita T, Dong Z, Katsumi A.Nakayama T, Kojima T, Saito H, Sadler JE, Naoe T.
    • Journal Title

      Biochem Biophys Res Commun. 339(4)

      Pages: 1178-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation2006

    • Author(s)
      Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.
    • Journal Title

      Leukemia 20

      Pages: 1168-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.2005

    • Author(s)
      Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.
    • Journal Title

      Int J Hematol 82

      Pages: 42-7

    • NAID

      10016602887

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells2005

    • Author(s)
      Takeshita A, Shinjo K, Naito K, Matsui H, Sahara N, Shigeno K, Horii T, Shirai N, Maekawa M, Ohnishi K, Naoe T, Ohno R.
    • Journal Title

      Leukemia 19

      Pages: 1306-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia2005

    • Author(s)
      Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.
    • Journal Title

      Blood 106

      Pages: 2854-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Journal Article] Integrin activation and matrix binding mediate cellar responses to mechanical stretch.2005

    • Author(s)
      Katsumi A, Naoe T et al.
    • Journal Title

      J Biol Chem. 280(17)

      Pages: 16546-16549

    • Data Source
      KAKENHI-PROJECT-17590989
  • [Journal Article] Normal and oncogenic FLT32004

    • Author(s)
      Naoe T
    • Journal Title

      Cell Mol Life Sci 61

      Pages: 2932-2938

    • Data Source
      KAKENHI-PROJECT-14030033
  • [Journal Article] Normal and oncogenic FLT3.2004

    • Author(s)
      Naoe T, et al.
    • Journal Title

      Cell Mol Life Sci 61(23)

      Pages: 2932-2938

    • Data Source
      KAKENHI-PROJECT-16390276
  • [Journal Article] Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice

    • Author(s)
      Tanizaki R, Naoe T., et al.
    • Journal Title

      Cancer Sci. 2009(in Press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Patent] 細胞を用いたデリバリーシステムの構築2010

    • Inventor(s)
      直江知樹, 他
    • Industrial Property Rights Holder
      北海道システム/法人岐大/法人名大
    • Filing Date
      2010-10-19
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006

    • Inventor(s)
      直江知樹、早川文彦、岡本充功
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Filing Date
      2006-06-02
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006

    • Inventor(s)
      直江知樹, 早川文彦, 岡本充功
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2006-155281
    • Filing Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390276
  • [Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006

    • Inventor(s)
      直江知樹, 早川文彦, 岡本充功
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2006-155281
    • Filing Date
      2006-06-02
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] TKI非感受性株に対するAIC-47の抗がん作用2015

    • Author(s)
      篠原悠、南陽介、熊崎実南、谷口高平、直江知樹、赤尾幸博.
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] 1353 Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations.2015

    • Author(s)
      Toshiyuki Nakatani,Ken Uda, Takeshi Yamaura, Masaru Takasaki, Akimi Akashi, Fangli Chen, , Yuichi Ishikawa, Fumihiko Hayakawa, Shinji Hagiwara, Hitoshi Kiyoi, and Tomoki Naoe
    • Organizer
      57th ASH Annual Meeting and Exposition
    • Place of Presentation
      Orange County Convention Center(米国)
    • Year and Date
      2015-12-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo.2015

    • Author(s)
      Takanobu Morishita, Fumihiko Hayakawa, Keiki Sugimoto, Daiki Hirano, Yuki Kojima, Naoto Imoto, Yuichiro Inagaki, Tomoki Naoe and Hitoshi Kiyoi.
    • Organizer
      57th ASH Annual Meeting and Exposition
    • Place of Presentation
      Orange County Convention Center(米国)
    • Year and Date
      2015-12-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Drug repositioning by patient-derived-xenograft screening for the discovery of new cure for PhALL.2015

    • Author(s)
      森下喬允、早川文彦、小島勇貴、井本直人、稲垣裕一郎、杉本慶樹、直江知樹、清井仁
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県金沢市)
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Ph陽性白血病に対するAIC-47のbcr-abl転写抑制とイマチニブの併用効果2015

    • Author(s)
      篠原悠、熊崎実南、谷口高平、倉永祐希、岩附綾子、酒井美来、直江知樹、赤尾幸博.
    • Organizer
      第19回日本がん分子標的治療学会
    • Place of Presentation
      松山全日空ホテル(愛媛県松山市)
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Ph陽性ALL新規治療薬発見のためのPDXスクリーニングによるドラッグリポジショニング.2015

    • Author(s)
      森下喬允、早川文彦、杉本慶樹、直江知樹、清井仁.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] イマチニブ非感受性白血病に対する新規脂肪酸誘導体AIC-47の増殖抑制作用2015

    • Author(s)
      篠原悠、南陽介、直江知樹、赤尾幸博.
    • Organizer
      第53回日本癌治療学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Mesenchymal stem cells stably transduced with a dominant negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage2013

    • Author(s)
      Nakayama T, Saito S, Naoe T
    • Organizer
      第61回日本輸血・細胞療法学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] A novel STAT inhibitor, OPB-31121, has a significant anti-tumor effect on STAT-dependent leukemia.2013

    • Author(s)
      Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Tomoki Naoe.
    • Organizer
      日本血液学会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Tratment with Hedgehog inhibitor,PF-04449913, atteuates leukemia-initiation potential in acute mveloid leukemia cells2013

    • Author(s)
      Nobuaki Fukushima,Yosuke Minami,Fumihiko Hayakawa,Hitoshi Kiyoi, Anil Sadarangani, PhD3*, Catriona HM Jamieson,Tomoki Naoe
    • Organizer
      米国血液学会
    • Place of Presentation
      ニューオリンズ
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] リンパ腫細胞環境をターゲットする薬剤開発2013

    • Author(s)
      杉本慶樹、早川文彦 直江 知樹
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Presentation] 正常及び変異FLT3共発現細胞の細胞増殖及びFLT3阻害剤効果に対するFLの抑制効果2013

    • Author(s)
      陳昉里、中谷俊幸、木原里香、清井仁、直江 知樹
    • Organizer
      日本血液学会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Analysis of rituximab resistance mechanism in CD20 positive B-cell lymphoma cells.2013

    • Author(s)
      Kazuyuki Shimada, Akihiro Tomita, Takashi Tokunaga, Chisako Iriyama, Tomohiro Kinoshita, Hitoshi kiyoi, Cragg Mark, Tomoki Naoe.
    • Organizer
      日本血液学会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Ri tuxi mab Sensitivity to De Novo DLBCL Cells Showing the Specific Phenotype of CD20 Protein Immunohistochemistry-Positive / Flow Cytometory-Negative: Analyses of Its Clinical Significances and the Molecular Mechanisms2012

    • Author(s)
      Tomi ta A, Naoe T,et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2012-12-09
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib2012

    • Author(s)
      Nakayama T, Mizuno H, Naoe T
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] Drug Development Targeting Microenvironment for Malignant Lymphoma ASH Annual Meeting Abstracts 2012 120:16612012

    • Author(s)
      Keiki Sugimoto, Fumihiko Hayakawa, Takahiko Yasuda, and Tomoki Naoe
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta (USA)
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] Rituximab Sensitivity to De Novo DLBCL Cells Showing the Specific Phenotype of CD20 Protein Immunohistochemistry-Positive / Flow Cytometory-Negative: Analyses of Its Clinical Significances and the Molecular Mechanisms.2012

    • Author(s)
      Tomita A, Naoe T,et al.
    • Organizer
      The American Society of Hematology 54th Annual Meeting.
    • Place of Presentation
      Atlanta USA
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Correlation of serum IL-6 with exhaustion of CMV-specific T cells after allogeneic stem cell transplantation2012

    • Author(s)
      Nishida T, Naoe T,et al
    • Organizer
      平成24年日本血液学会.
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Year and Date
      2012-10-19
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Outcome of Pediatric-Type Therapy for Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA): A Study by the Japan Adult Leukemia Study Group (JALSG ALL202-U study)2012

    • Author(s)
      Sakura T, Naoe T,et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] The effectiveness of macrophage-targeted therapy by dexamethasone palmitate for refractory GVHD2012

    • Author(s)
      Takayuki Nakayama, Satoshi Nishiwaki, Makoto Murata, Tetsuya Nishida, Seitaro Terakura, Shigeki Saito, Tomoki Naoe et al.
    • Organizer
      The 74th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] Wnt signaling is associated with anti-apoptosis in the interaction between acute myeloid leukemia cells and stromal cells2012

    • Author(s)
      Minami Y, Naoe T, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Usefulness of Peripheral Blood Circulating DNAs As an Alternative to DNA From Bone Marrow Cells to Detect CpG Global Methylation Status and Genetic Mutations in Patients with Myelodysplastic Syndromes.2012

    • Author(s)
      Iriyama C, Tomita A, Naoe T, et al.
    • Organizer
      The American Society of Hematology 54th Annual Meeting.
    • Place of Presentation
      Atlanta USA
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Incidence and Clinical Features of Core Binding Factor Acute Myeloid Leukemia: A Collaborative Study of the Japan Adult Leukemia Study Group and the Korean Society of Hematology2012

    • Author(s)
      Taki T, Kiyoi H, Naoe T, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] EVI1 elicits resistance to apoptosis which can be overcome through application of AKTi or ABT-7372012

    • Author(s)
      島田和之,直江知樹,他
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Usefulness of Peripheral Blood Circulating DNAs As an Alternative to DNA From Bone Marrow Cells to Detect CpG Global Methylation Status and Genetic Mutations in Patients with Myelodysplastic Syndromes2012

    • Author(s)
      Iriyama C, Tomita A, Naoe T,et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Year and Date
      2012-12-10
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Drug Development Targeting Microenvironment for Malignant Lymphoma ASH Annual Meeting Abstracts 2012 120:16612012

    • Author(s)
      Sugimoto K, Hayakawa F, Yasuda T, and Naoe T.
    • Organizer
      第54回アメリカ血液学会
    • Place of Presentation
      Atlanta (USA)
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells2012

    • Author(s)
      Yosuke Minami, Yosuke Niwa, Akihiro Abe, Fumihiko Hayakawa, and Tomoki Naoe
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta (USA).
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] The effectiveness of macrophage-targeted therapy by dexamethasone palmitate for refractory GVHD2012

    • Author(s)
      Nishiwaki S, Nakayama T, Naoe T.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] Leukaemia escape from HLA-specific T-lymphocyte pressure in a recipient of HLA one locus-mismatched BMT2012

    • Author(s)
      Murata M, Naoe T,et al
    • Organizer
      The 38th Annual Meeting of the European Group for Blood and Marrow Transplantation.
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2012-04-01
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells.2012

    • Author(s)
      Minami Y, Niwa Y, Abe A, Hayakawa F, and Naoe T.
    • Organizer
      第54回アメリカ血液学会
    • Place of Presentation
      Atlanta (USA)
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] 造血支持を目的としたヒト脂肪組織由来間葉系幹細胞の有効性、安全性の検討2011

    • Author(s)
      中山享之、中尾典彦、直江知樹
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011

    • Author(s)
      Hayakawa F, Sugimoto K, Kurahashi S, Sumida T, Naoe T.
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-12-10
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] CD20 Protein Immunohistochemistry-Positive/Flow Cytometry-Negative Diffuse Large B-Cell Lymphoma-Analyses of the Molecular Mechanisms and Rituximab Effectiveness2011

    • Author(s)
      Tokunaga T, Naoe T,et al
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-12-11
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells.2011

    • Author(s)
      Hayakawa F, Sugimoto K, Kurahashi S, Sumida T, Naoe T.
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] RhoH Downregulates Rac Through RhoGAP Family Protein.2011

    • Author(s)
      Katsumi A, Kobayashi M, Matsushita T, Kiyoi H, Kojima T, Maruyama M, Kaibuchi K, Naoe T.
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] RhoH Downregulates Rac Through RhoGAP Family Protein2011

    • Author(s)
      Katsumi A, Naoe T,et al
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2ndABL-TKI Treatment in Ph+ Leukemia Cells2011

    • Author(s)
      Minami Y, Abe A, Minami M, Kuwatsuka Y, Fukushima N, Kitamura K, Hiraga J, Yamamoto K, Jamieson C, Naoe T
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-12-10
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2nd ABL-TKI Treatment in Ph+ Leukemia Cells2011

    • Author(s)
      Minami Y, Naoe T,et al
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011

    • Author(s)
      Hayakawa F, Naoe T,et al
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2nd ABL-TKI Treatment in Ph+ Leukemia Cells.2011

    • Author(s)
      Minami Y, Abe A, Minami M, Kuwatsuka Y, Fukushima N, Kitamura K, Hiraga J, Yamamoto K, Jamieson C, Naoe T.
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23659487
  • [Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011

    • Author(s)
      Hayakawa F, Naoe T, et al
    • Organizer
      53^<rd> ASH Annual Meeting and Exposition
    • Place of Presentation
      San Diego, CA U.S.A
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Biomarkers In Cell Death of Imatinib-Resistant Ph-Leukemia Cells During Treatment with mTOR Inhibitor, Everolimus2010

    • Author(s)
      Miho M, Naoe T, et al
    • Organizer
      The American Society of Hematology 53th Annual Meeting
    • Place of Presentation
      Orlando USA
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Biomarkers In Cell Death of Imatinib-Resistant Ph-Leukemia Cells During Treatment with mTOR Inhibitor, Everolimus.2010

    • Author(s)
      Miho M, Naoe T, et al.
    • Organizer
      52nd ASH Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL U.S.A
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-22390192
  • [Presentation] Evaluation of BCR-ABL-positive leukemia stem cells with imatinib-therapy and apoptosis induced by bortezomib-treatment2009

    • Author(s)
      南陽介, 安部明弘, 鍬塚八千代, 野村由佳, 谷崎亮平, 直江知樹
    • Organizer
      第7回幹細胞シンポジウム(一般演題)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Treatment with mTOR Inhibitor, Everolimus (RAD001) Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent or T315I-Mutated Cells2009

    • Author(s)
      Minami Y, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] Double Genetic Mutations in PML-Rara Fusion Gene Confirmed in a Patient Showing Resistance to All-Trans Retinoic Acid and Arsenic-Trioxide Therapy2009

    • Author(s)
      Goto E, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] Ph陽性白血病幹細胞におけるイマチニブ耐性とボルテゾミブによる克服の可能性2009

    • Author(s)
      南陽介, 鍬塚八千代, 谷崎亮平, 野村由佳, 安部明弘, 清井仁, 直江知樹
    • Organizer
      第18回日本アポトーシス研究会(一般口演)
    • Place of Presentation
      長崎
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Treatment with BortezomibOvercomes Resistance to Imatinib in Ph-Leukemia Quiescent Cells2009

    • Author(s)
      Kuwatsuka Y, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] MS4A1 (CD20) Gene Expression Is Down-Regulated by Recruiting the Histone Deacetylase Protein Complex to the Promoter in the CD20-Negative B-Lymphoma Cells After Treatment with Rituximab2009

    • Author(s)
      Sugimoto T, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] FLT3/ITD Regulates Leukemia Cell Adhesion throughα4β1 Integrin and Pyk2 Signaling2009

    • Author(s)
      Katsumi A, Kiyoi H, Abe A, Naoe T
    • Organizer
      The 51st ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, LA
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Treatment with mTOR Inhibitor, Everolimus (RAD001) Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent or T315I-Mutated Cells2009

    • Author(s)
      Minami Y, Minami M, Kuwatsuka Y, Tanizaki R, Nomura Y, Abe A, Kiyoi H, Naoe T
    • Organizer
      The 51st ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] FLT3/ITD Regulates Leukemia Cell Adhesion throughα4β1 Integrin and Pyk2 Signalin2009

    • Author(s)
      Katsumi A, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] FL-Dependent Wild-Type FLT3 Signals Reduce the Inhibitory Effects of FLT3 Inhibitors On Wild-Type and Mutant FLT3 Co-Expressing Cel2009

    • Author(s)
      Mori Y, Naoe T, et al.
    • Organizer
      The American Society of Hematology 51th Annual Meeting
    • Place of Presentation
      New Orleans USA
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] Ph陽性白血病幹細胞におけるイマチニブ耐性とボルテゾミブによる克服の可能性2009

    • Author(s)
      南陽介鍬塚八千代谷崎亮平安部明弘直江知樹
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜(一般口演)
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Treatment with Bortezomib Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent Cells2009

    • Author(s)
      Kuwatsuka Y, Minami Y, Tanizaki R, Minami M, Abe A, Nomura Y, Kiyoi H, Naoe T
    • Organizer
      The 51st ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, LA
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Hsp90 inhibitor, 17-AAG overcome resistance of FLT3-inhibitor in MOLM13N676K2008

    • Author(s)
      Y Minami, Y Nomura, A Abe, R Tanizaki, Y Shiotsu, S Akinaga, H Kiyoi, T Naoe
    • Organizer
      50th ASH meeting
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] FLT3/ITD regulates leukemia cell adhesion through a4b1 integrin and Pyk2 signaling2008

    • Author(s)
      勝見章、清井仁、安部明弘、谷崎亮平、松下正、小嶋哲人、直江知樹
    • Organizer
      第71回日本血液学会学術総会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] KW-2449, a Novel Multi-Kinase Inhibitor, Suppresses the Growth of Imatinib-Resistant Ph+ Leukemia Including BCR-ABL/T315I Both in Vitro and in Vivo2008

    • Author(s)
      Shiotsu Y and Naoe T, et.al.
    • Organizer
      ASH Annual Meeting 2008
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-08
    • Data Source
      KAKENHI-PROJECT-17016029
  • [Presentation] Philadelphia染色体陽性急性リンパ芽球性白血病由来Imatinib耐性株の樹立とその耐性化機序の解析2008

    • Author(s)
      西岡百子、安部明弘、今釜静香、谷崎亮平、勝見章、南陽介、早川文彦、山本一仁、直江知樹
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Transformation of E2A-deficient pluripotent progenitors by BCR-ABL generates imatinib-resistant leukemic stem cells2008

    • Author(s)
      Minami Y, Abe A, Ikawa T, Stuart S, Jamieson CHM, Naoe T
    • Organizer
      Wang JYJ 50th ASH meeting
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Evaluation of residual leukemia stem cells in chronic myeloid leukemia with imatinib therapy2008

    • Author(s)
      南陽介, 安部明弘, 鍬塚八千代, 早川文彦, 谷崎亮平, 勝見章, 清井仁, 直江知樹
    • Organizer
      第67回日本癌学会総会(ワークショップ)
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] 慢性骨髄性白血病幹前駆細胞に対するイマチニブの効果:マウス多能性造血細胞モデル及び治療後残存腫瘍解析2008

    • Author(s)
      南陽介、安部明弘、伊川友活、Scott Stuart, 早川文彦、北村邦朗、野村由佳、Catriona Jamieson, Jean Wang, 直江知樹
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-19390261
  • [Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.

    • Author(s)
      Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
    • Organizer
      第5回日本血液学会(JSH)国際シンポジウム
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市中区)
    • Year and Date
      2014-05-24 – 2014-05-25
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Presentation] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib

    • Author(s)
      Nakayama T, Mizuno H, Naoe T
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver, BC, Canada
    • Data Source
      KAKENHI-PROJECT-23591382
  • [Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.

    • Author(s)
      島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.

    • Author(s)
      稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
    • Organizer
      第56回米国血液学会
    • Place of Presentation
      Moscone Center (サンフランシスコ、米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.

    • Author(s)
      島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.

    • Author(s)
      Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
    • Organizer
      第5回日本血液学会(JSH)国際シンポジウム
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市中区)
    • Year and Date
      2014-05-24 – 2014-05-25
    • Data Source
      KAKENHI-PROJECT-25293218
  • [Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.

    • Author(s)
      Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
    • Organizer
      第56回米国血液学会
    • Place of Presentation
      Moscone Center (サンフランシスコ、米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.

    • Author(s)
      稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
    • Organizer
      第56回米国血液学会
    • Place of Presentation
      Moscone Center (サンフランシスコ、米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25670449
  • [Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.

    • Author(s)
      Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
    • Organizer
      第56回米国血液学会
    • Place of Presentation
      Moscone Center (サンフランシスコ、米国)
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-25293218
  • 1.  OHNO Ryuzo (70093002)
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 6 results
    # of Collaborated Products: 13 results
  • 3.  KITAMURA Kunio
    # of Collaborated Projects: 5 results
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    # of Collaborated Projects: 4 results
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    # of Collaborated Projects: 3 results
    # of Collaborated Products: 17 results
  • 7.  本間 良夫 (70142114)
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 13.  HAYAKAWA Fumihiko (30402580)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 25 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
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    # of Collaborated Products: 8 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  CHEN Sai-juan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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  • 53.  森下 剛久
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  CHUO Dong
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 56.  ANDO Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  小川 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  山本 幸也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  西脇 聡史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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