TANAKA Tomoyuki 田中智之

Researcher Number	50227154
Affiliation (based on the past Project Information) *help	2011: 英国ダンディー大学, 生命科学科, 教授 1996 – 1997: University of Tokyo, Hospital, Internal Medicine, Assistant Professor, 医学部・附属病院, 助手 1994 – 1995: University of Tokyo, Department of Internal Medicine, Assistant Professor, 医学部(病), 助手 1991 – 1993: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / General medical chemistry Except Principal Investigator Hematology / Cell biology
Keywords	Principal Investigator 転写因子 / 白血病 / Phosphorylation / Leukemia / Cell Proliferation / Cell Diffrerntiation / Hematopoietic Cell / Transcription Factor / AML1 gene / リン酸化 … More / 細胞増殖 / 細胞分化 / 造血細胞 / AML1遺伝子 / 染色体転座 / Evi-1 / AML1 / プロテインキナーゼC / アクチン類以タンパク質 / アクチン2 … More Except Principal Investigator 転写因子 / AML1 / 慢性骨髄性白血病 / 染色体転座 / chromosomal translocation / 急性転化 / transcription factor / MEN / ALL / キメラ蛋白質 / 細胞分化 / リン酸化 / EVI-1キメラ遺伝子 / 癌抑制遺伝子 / Evi-1 / 白血病 / chimeric protein / EVI-1 / t(3;21)転座 / 転座型白血病 / EVi-1 / AML-1 / 細胞周期 / MLL / t(11;19) / 骨髄異形成症候群 / p16遺伝子 / 転写制御因子 / 細胞増殖 / 造血細胞 / 転写活性 / Evi-1融合蛋白質 / AML1遺伝子 / レドックス制御 / 転写調節 / AP-1 activity / leukemia / t(11 ; 19) / elongation factor / RNA polymerase II elongation factor / 伸長因子 / t(11;19)(q.23;P13.1) / AP-1活性 / 転写伸長因子 / RNAポリメラーゼII伸長因子 / phosphorylation / myelogenous leukemias / extracellular signal-regulated kinase / AML1 gene / MAPキナーゼ / 染色体転写 / 急性骨髄性白血病 / Tumor Suppressor Gene / RB Protein / p53 Gene / p16INK4A Gene / Cell Cycle / Evi-1 Gene / Blastic Crisis / Chronic Myelocytic Leukemia / RB蛋白質 / p53遺伝子 / p16INK4A遺伝子 / Evi-1遺伝子 / growth stimulation / differentiation suppression / blastic crisis / CML / 増殖促進 / 分化抑制 / p16 gene / suppressor oncogene / 複合転座 / RT-PCR法 / t(15;17)転座 / RARのキメラ遺伝子 / PML / 急性前骨髄球性白血病 / 癌抑制遺 / ets oncogene / differentiation / 顆粒球単球 / ets癌遺伝子 / 血球分化 / 微小管 / キネトコア / 細胞分裂 / 染色体分配 / EPI-1 / t(3;21) / 前白血病 / 癌遺伝子 / 受容体 / 情報伝達 / 造血因子 / 癌抑制 / 転写伸長活性 / MEN遺伝子 / MLL遺伝子 / 11q23転座 / 造血器腫瘍 / t(3;21)染色体転座 / FISH法 / 発癌機構 / 染色体欠失 / 非ホジキンリンパ腫 / 急性リンパ性白血病 / アポトーシス / ストレス刺激 / JNK / MAP kinase / zinc finger / 核内蛋白質 / 細胞内情報伝達機構 / チロシンリン酸化 / チロシンキナーゼ / Vav / Ash / Grb2 / インターロイキン(IL)-3 / エリスロポエチン / GM-CSF / インターロイキン5 / 成人T細胞性白血病 / ストレス蛋白質 / レドックス Less

Molecular network supporting chromosomal stability
- Principal Investigator
  
  TANAKA Kozo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Functional regulation by phosphorylation of transcription factor AML1 which is involved in leukemogenesisPrincipal Investigator
- Principal Investigator
  
  TANAKA Tomotuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  TOKYO UNIVERSITY
Analysis of transcription factor abnormality in the progression of preleukemic state.
- Principal Investigator
  
  MITANI Kinuko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo University
造血因子のレセプターからRasに至る細胞内情報伝達機構
- Principal Investigator
  
  花園豊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒト前白血病における転写因子異常の解析
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
21番染色体転座によるAML1の機能変化と白血病発症機構の解明Principal Investigator
- Principal Investigator
  
  田中智之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Analysis of Molecular Mechanism of Blastic Crisis in Chronic Myelocytic Leukemia
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tokyo
Functional analysis of AML1 gene in normal hematopoietic cells and leukemia cells
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo
造血細胞のチロシンキナーゼを介する情報伝達機構
- Principal Investigator
  
  HANAZONO Yutaka
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
造血器腫瘍の遺伝子診断法の開発と実用化
- Principal Investigator
  
  平井久丸
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
レドックス蛋白質の機能解析および癌診断への応用
- Principal Investigator
  
  NISHIDA Junji
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
成人T細胞性白血病細胞に特異的な転写機構の解明と癌化との関連
- Principal Investigator
  
  西田淳二
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
アクチン類以タンパク質、アクチン2の機能解析Principal Investigator
- Principal Investigator
  
  田中智之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Jichi Medical University
Molecular analysis of leukemias with chromosomal translocation and its application for clinical Diagnosis
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo
Development and clinical application of molecular diagnosis in leukemias
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo
Involvement of ets oncogene family in chromosomal translocation and hemopoietic cell dofferentiation into granulocyte/macrophage lineage
- Principal Investigator
  
  NISHIDA Junji
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

All 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] CAMPによるキネトコア-微小管結合の制御2011
- Author(s)
  田中耕三
- Journal Title
  
  生体の科学
  
  Volume: 62 Pages: 468-469
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis2011
- Author(s)
  Gandhi, S, R, Gierlinski, M, Mino, A, Tanaka, K, Kitamura, E, Clayton, L, and Tanaka, T, U
- Journal Title
  
  Dev Cell
  
  Volume: 21 Pages: 920-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation2011
- Author(s)
  †Kawashima, S, †Nakabayashi, Y(†equally contributors), Matsubara, K, Sano, N, Enomoto, T, * Tanaka, K, * Seki, M, and * Horikoshi, M(* joint corresponding authors).
- Journal Title
  
  EMBO J
  
  Volume: 30 Pages: 3353-3367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] キネトコアと微小管の結合を制御するタンパク質CAMP2011
- Author(s)
  田中耕三
- Journal Title
  
  生体の科学
  
  Volume: 62 Pages: 468-469
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] CAMP(C13orf8, ZNF828)is a novel regulator of kinetochore-microtubule attachment2011
- Author(s)
  toh, G, Kanno, S, Uchida, K, S, K, Chiba, S, Sugino, S, Watanabe, K, Mizuno, K, Yasui, A, Hirota, T, and Tanaka, K
- Journal Title
  
  EMBO J
  
  Volume: 30 Pages: 130-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Nocodazole induces mitotic cell death with apoptotic-like features in Saccharomyces cerevisiae2010
- Author(s)
  Endo, K, Mizuguchi, M, Harata, A, Itoh, G, and Tanaka, K
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 2387-2392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Live cell analysis of kinetochore-microtubules interaction in budding yeast2010
- Author(s)
  Tanaka, K
- Journal Title
  
  Methods (In press)
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Live cell analysis of kinetochore-microtubules interaction in buddingyeast2010
- Author(s)
  Tanaka, K
- Journal Title
  
  Methods
  
  Volume: 51 Pages: 206-213
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Live cell analysis of kinetochore-microtubules interaction in budding yeast2010
- Author(s)
  Tanaka, K, Kitamura, E, and Tanaka, T, U
- Journal Title
  
  Methods
  
  Volume: 51 Pages: 206-213
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Kinetochores generate microtubules with distal plus ends : their roles and limited lifetime in mitosis2010
- Author(s)
  Kitamura, E, Tanaka, K, Komoto, S(tequally contributors), Kitamura, Y, Antony, C, and Tanaka, T, U
- Journal Title
  
  Dev Cell
  
  Volume: 18 Pages: 248-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Live cell imaging of kinetochore capture by microtubules in budding yeast2009
- Author(s)
  Tanaka, K
- Journal Title
  
  Methods Mol Biol 545
  
  Pages: 233-242
- Data Source
  KAKENHI-PROJECT-21570193
[Journal Article] Live cell imaging of kinetochore capture by microtubules in budding yeast2009
- Author(s)
  Tanaka, K, and Tanaka, T, U
- Journal Title
  
  Methods Mol Biol
  
  Volume: 545 Pages: 233-242
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 規分子CAMPのキネトコア-微小管結合に関する機能2012
- Author(s)
  伊藤剛, 菅野新一郎, 内田和彦, 千葉秀平, 水野健作, 安井明, 広田亨, 田中耕三
- Organizer
  第29回染色体ワークショップ
- Place of Presentation
  仙台
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] タキサン系抗がん剤の作用機序について2011
- Author(s)
  田中耕三
- Organizer
  第17回北日本肺癌臨床研究会
- Place of Presentation
  仙台
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規分子CAMPによるキネトコア-微小管結合の制御2011
- Author(s)
  田中耕三
- Organizer
  第16回東北大学学際ライフサイエンスシンポジウム
- Place of Presentation
  東北大学
- Year and Date
  2011-11-01
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] Mechanisms of mitotic regulation in relation to oncogenesis and anti-cancer therapy2011
- Author(s)
  田中耕三
- Organizer
  第6回研究所ネットワーク国際シンポジウム
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] CAMP (C13orf8, ZNF828) is a novel regulator or kinetochore-microtubule attachment2011
- Author(s)
  田中耕三
- Organizer
  6^<th> UK-Japan Cell Cycle Workshop
- Place of Presentation
  Windermere, UK
- Year and Date
  2011-04-13
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 染色体整列に働く新規分子CAMPの機能について2011
- Author(s)
  伊藤剛, 田中耕三
- Organizer
  日本生化学会東北支部第77回シンポジウム
- Place of Presentation
  東北大学
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] CAMP(C13orf8, ZNF828)is a novel regulator or kinetochore-microtubule attachment2011
- Author(s)
  田中耕三
- Organizer
  6th UK-Japan Cell Cycle Workshop
- Place of Presentation
  Windermere, UK
- Year and Date
  2011-04-13
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] Maintenance of kinetochore-microtubule attachment by a novel protein, CAMP (C13orf8)2011
- Author(s)
  田中耕三
- Organizer
  特定領域研究「細胞周期フロンティア-増殖と分化相関」公開国際シンポジウム"Cell Division"
- Place of Presentation
  箱根
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] タキサン系抗がん剤の作用機序について2011
- Author(s)
  田中耕三
- Organizer
  第17回北日本肺癌臨床研究会
- Place of Presentation
  仙台.
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] Maintenance of kinetochore-microtubule attachment by a novel protein, CAMP(C13orf8)2011
- Author(s)
  田中耕三
- Organizer
  特定領域研究「細胞周期フロンティア-増殖と分化相関」公開国際シンポジウム"Cell Division"
- Place of Presentation
  箱根
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規分子CAMP(C13orf8, ZNF828)によるキネトコア-微小管結合の制御2011
- Author(s)
  伊藤剛, 菅野新一郎, 内田和彦, 千葉秀平, 水野健作, 安井明, 広田亨, 田中耕三
- Organizer
  第28回染色体ワークショップ
- Place of Presentation
  加賀
- Year and Date
  2011-01-11
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規分子CAMP(C13orf80 ZNF828)によるキネトコア・微小管結合の制御2011
- Author(s)
  田中耕三
- Organizer
  第28回染色体ワークショップ
- Place of Presentation
  加賀
- Year and Date
  2011-01-11
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] Function of CAMP(C13orf8, ZNF828)in kinetochore-microtubule attachment2011
- Author(s)
  伊藤剛, 菅野新一郎, 内田和彦, 千葉秀平, 水野健作, 安井明, 広田亨, 田中耕三
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規分子CAMPによるキネトコア-微小管結合の制御2010
- Author(s)
  田中耕三
- Organizer
  平成22年度遺伝研研究会
- Place of Presentation
  三島
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] CAMP(C13orf8, ZNF828)is a novel regulator of kinetochore-microtubule attachment2010
- Author(s)
  伊藤剛, 菅野新一郎, 内田和彦, 千葉秀平, 水野健作, 安井明, 広田亨, 田中耕三
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規MAD2L2結合分子CAMP(C13orf8, ZNF828)によるキネトコア-微小管結合の制御2010
- Author(s)
  伊藤剛, 菅野新一郎, 内田和彦, 千葉秀平, 水野健作, 安井明, 広田亨, 田中耕三
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  伊豆
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] MAD2L2と結合する新規分子C13orf8によるキネトコア-微小管結合の制御2010
- Author(s)
  伊藤剛, 菅野新一郎, 安井明, 広田亨, 田中耕三
- Organizer
  第27回染色体ワークショップ
- Place of Presentation
  御殿場
- Year and Date
  2010-01-20
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] A novel MAD2L2-interacting protein, CAMP, is a regulator of kinetochore-microtubule attachment2010
- Author(s)
  田中耕三, 伊藤剛, 安井明, 広田亨
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規分子CAMPによるキネトコア・微小管結合の制御2010
- Author(s)
  田中耕三
- Organizer
  平成22年度遺伝研研究会
- Place of Presentation
  三島
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規MAD2L2結合分子CAMP(C13orf8, ZNF828)によるキネトコア・微小管結合の制御2010
- Author(s)
  田中耕三
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  伊豆
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21570193
[Presentation] 新規MAD2結合分子MAD2BP1によるキネトコア-微小管結合の制御2009
- Author(s)
  伊藤剛, 菅野新一郎, 安井明, 広田亨, 田中耕三
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21570193

1. HIRAI Hisamaru (90181130)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. MITANI Kinuko (50251244)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. HANAZONO Yutaka (70251246)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. OGAWA Seishi (60292900)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. KUROKAWA Mineo

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. SAKAI Ryu-ichi (40215603)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NISHIDA Junji (80228189)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SASAKI Ko (60282638)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 本田浩章 (40245064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 千葉滋 (60212049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 宮川清 (40200133)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. HIRANO Naoto

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TANAKA Kozo (00304452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 33 results
14. YASUI Akira (60191110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
15. ITOH Go (60607563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
16. KANNO Shinichiro (10400417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
17. 豊島秀男 (20197966)

# of Collaborated Projects: 1 results

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18. 間野博行 (90240704)

# of Collaborated Projects: 1 results

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19. UENO Hiroo

# of Collaborated Projects: 1 results

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20. 今井陽一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高橋宗春

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山形哲也

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 杉本耕一

# of Collaborated Projects: 1 results

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24. WITTE Owen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. QWEN Witte

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TANAKA Tomoyuki 田中 智之

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Functional regulation by phosphorylation of transcription factor AML1 which is involved in leukemogenesisPrincipal Investigator

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21番染色体転座によるAML1の機能変化と白血病発症機構の解明Principal Investigator

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アクチン類以タンパク質、アクチン2の機能解析Principal Investigator

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TANAKA Tomoyuki 田中智之