OHSHIMA Shigetoshi 大嶋重敏

Researcher Number	50375268
Affiliation (based on the past Project Information) *help	2007 – 2013: Akita Univ., 1^<st> Dept. of Medicine, Assistant Professor 2007: Akita University, School of Medicine, assistant professor 2006: 秋田大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator Pten遺伝子 / NASH / PTEN / 肥満 / 遺伝子治療 / ob/obマウス / Ob / マウス / Obマウス / 酸化ストレス … More Except Principal Investigator 脂肪性肝炎 / イノシトールリン脂質 / PTEN / autophagosome / autolysosome / class I PI3-kinase / 肝臓学 / 肝腫瘍性病変 / 肝癌 / Akt2 / PPARγ / INPP4B / Pten / 炎症性腸疾患 / マウスモデル / 潰瘍性大腸炎 / クローン病 / 酸化ストレス / 肝発癌 / 抗酸化剤 / N-アセチルシステイン / steatohepatitis / oxidative stress / hepatic caricinogenesis / antioxidant / N-acetyleisteine / オートファジー / Pten遺伝子 / Atg複合体 / 炎症 / 線維化 / 発癌 / autophagy / Pten gene / Atg conjugation Less

炎症性腸疾患の発症に関わる腸上皮細胞におけるイノシトールリン脂質代謝異常の解明
- Principal Investigator
  
  堀江泰夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Elucidation of the phosphatidylinositol metabolism to control steatohepatitis and hepatocellular carcinoma
- Principal Investigator
  
  HORIE Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Study for therapeutic effect of hepatocyte specific Pten deficiency on severe obesity.Principal Investigator
- Principal Investigator
  
  OHSHIMA Shigetoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Akita University
Role of lipid and oxidative stress on carcinogenesis in the digestive system
- Principal Investigator
  
  WATANABE Sumio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Juntendo University
Autophagy is involved in inflammation, fibrosis, and carcinogenesis-A study using mice model
- Principal Investigator
  
  HORIE Yasuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
The study of NASH mechanism-in terms of reactive oxygen species and mitochondrial function-Principal Investigator
- Principal Investigator
  
  OHSHIMA Shigetoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University

All 2011 2007 2006 Other

All Journal Article Presentation

[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma lessons fromhepatocyte-specific phosphatase and tensin homolog(PTEN)-deficient mice2007
- Author(s)
  Watanabe S, Horie Y, Kataoka E, Sato W, Dohmen T, Ohshima S, Goto T, Suzuki A.
- Journal Title
  
  J.Gastroenterol.Hepatol. 22(Suppl1)
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Nonalcoholie steatohepatitis and hepatoellular careinoma : lessons from hepatoeyte-speeific phosphatase and tensin homolog (PTEN)-defieiet mice.2007
- Author(s)
  Wattanabe S, Horio Y. Kataoka E, Sato W, Dohmon T. Ohshima S. Goto T. Suzuki A.
- Journal Title
  
  J. Gastroenterol. Hepatol. 22(Suppl1)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma : lessons from hepatoeyte-specific phosphatase and tensin homolog (PTEN)-defient mice.2007
- Author(s)
  Watanabe S. Horie Y. Kataoka E. Sato W. Dohmon T. Ohshima S. Goto T. Suzuki A.
- Journal Title
  
  J. Gastroenterol. Hepatol 22 (Suppl 1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390213
[Journal Article] Hepatic gene ezpression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge2006
- Author(s)
  Sato W, Horie Y, Kataoka E, Ohshima S, Dohmen T, Iizuka M, Sasaki J, Sasaki M, Hamada K, Kishimoto H, Suzuki A, Watanabe S
- Journal Title
  
  HEPATOLOGY RESEARCH 34
  
  Pages: 256-265
- Data Source
  KAKENHI-PROJECT-18390213
[Presentation] 肝細胞特異的Pten欠損によるレプチン欠損ob/obマウスの肥満の改善2011
- Author(s)
  大嶋重敏,堀江泰夫,後藤隆,三浦光一,澁谷友美,佐藤亘,道免孝洋,姉崎有美子,山田育弘,鎌田健太郎,鈴木聡,大西洋英
- Organizer
  肝臓病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-20591041
[Presentation] Hepatocyte-specific Pten deficiency improves obesity in the leptin-deficient ob/ob mouse.2011
- Author(s)
  Shigetoshi Ohshima, Yasuo Horie, Takashi Goto, Kouichi Miura, Akira Suzuki, Hirohide Ohnishi
- Organizer
  DDW2011
- Place of Presentation
  Chicago
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-20591041
[Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using patocyte-specific Pten deficient mice2007
- Author(s)
  Shigetoshi Ohshima, Yasuo HorieTakahiro Domen, et. al.
- Organizer
  Liver disease society.(EASL)
- Year and Date
  2007-04-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590714
[Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using hepatocyte-specific Pten deficient mice-2007
- Author(s)
  Shigetoshi, Ohshima, Yasuo, Horie, Takahiro, Domen, et. al
- Organizer
  ヨーロッパ肝臓病学会(EASL)
- Place of Presentation
  スペイン,バルセロナ
- Year and Date
  2007-04-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590714
[Presentation] Eicosapentaenoic acid improve steatohepatitis in newly established mice Model of nonalcoholic steatohepatitis2007
- Author(s)
  Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima et.al
- Organizer
  ヨーロッパ肝臓病学会(EASL)
- Place of Presentation
  スペイン,バルセロナ
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-18590714
[Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討2007
- Author(s)
  堀江泰夫, 大嶋重敏, 渡辺純夫
- Organizer
  JDDW2007
- Place of Presentation
  神戸
- Year and Date
  2007-10-20
- Data Source
  KAKENHI-PROJECT-18590714
[Presentation] 肝細胞特異的Pten欠損マウスを用いたNASHに対する有効薬剤の検討
- Author(s)
  堀江泰夫、大嶋重敏、渡辺純夫
- Data Source
  KAKENHI-PROJECT-18390213

1. HORIE Yasuo (30282164)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. WATANABE Sumio (20138225)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. OHNISHI Hirohide (00313023)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SASAKI Takehiko (50333365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IKEJIMA Kenichi (20317382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHSHIMA Shigetoshi 大嶋 重敏

Research Projects

Research Products

Co-Researchers

炎症性腸疾患の発症に関わる腸上皮細胞におけるイノシトールリン脂質代謝異常の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the phosphatidylinositol metabolism to control steatohepatitis and hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for therapeutic effect of hepatocyte specific Pten deficiency on severe obesity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of lipid and oxidative stress on carcinogenesis in the digestive system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autophagy is involved in inflammation, fibrosis, and carcinogenesis-A study using mice model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of NASH mechanism-in terms of reactive oxygen species and mitochondrial function-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma lessons fromhepatocyte-specific phosphatase and tensin homolog(PTEN)-deficient mice2007

Author(s)

Journal Title

Data Source

[Journal Article] Nonalcoholie steatohepatitis and hepatoellular careinoma : lessons from hepatoeyte-speeific phosphatase and tensin homolog (PTEN)-defieiet mice.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Non-alcoholic steatohepatitis and hepatocellular carcinoma : lessons from hepatoeyte-specific phosphatase and tensin homolog (PTEN)-defient mice.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Hepatic gene ezpression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge2006

Author(s)

Journal Title

Data Source

[Presentation] 肝細胞特異的Pten欠損によるレプチン欠損ob/obマウスの肥満の改善2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Hepatocyte-specific Pten deficiency improves obesity in the leptin-deficient ob/ob mouse.2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using patocyte-specific Pten deficient mice2007

Author(s)

Organizer

Year and Date

Description

Data Source

[Presentation] N-acetyl-L-cystein blocks progression of NASH by reducing reactive oxygen species-An examination using hepatocyte-specific Pten deficient mice-2007

Author(s)

Organizer

Place of Presentation

OHSHIMA Shigetoshi 大嶋重敏