Takigawa Nagio 瀧川奈義夫

… Alternative Names

TAKIGAWA Nagio 瀧川奈義夫

滝川奈義夫タキガワナギオ

瀧川奈義夫タキガワヤギオ

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Researcher Number	60325107
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2024: 川崎医科大学, 医学部, 教授 2016: 川崎医科大学, 総合内科学4, 教授 2010: 岡山大学, 岡山大学病院, 助教 2010: 岡山大学, 病院, 助教 2009: Okayama University, 大学病院, 助教 … More 2007 – 2008: Okayama University, 医学部・歯学部附属病院, 助教 2007: 医学部, 歯学部附属病院, 助教 2006: 岡山大学, 医学部・歯学部附属病院, 助手 2000: 岡山大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine / Tumor therapeutics / Basic Section 55040:Respiratory surgery-related / Basic Section 56020:Orthopedics-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Biological Sciences
Keywords	Principal Investigator EGFR / 肺癌 / 薬剤耐性 / ALK / プロテオーム / JAK2 / 肺腺癌 / 遺伝子変異 / 発癌 / トランスクリプトーム … More / メタボローム / 代謝 / チロシンキナーゼ阻害剤 / APOBEC / APOBEC3B / チロシンキナーゼ阻害 / プロテオーム解析 / 血管新生 / 遺伝子改変マウス / STAT3 / mTOR / 重複癌 … More Except Principal Investigator EGFR / 肺癌 / 遺伝子改変マウス / ゲフィチニブ / 上皮成長因子受容体 / 肺大細胞神経内分泌癌 / 肺大細胞性神経内分泌癌 / オルガノイド / 肺大細胞神経内分泌 / 治療シークエンス / 新規抗がん剤 / IC50値 / 耐性株 / アポトーシス / Eribulin / Trabectedin / Doxorubicin / 軟部肉腫 / 炎症性サイトカイン / 血清CRP値 / ヘプシジン / がん性悪液質 / 固形腫瘍 / 予後予測因子 / Paps / 予後相関 / 赤血球沈降速度 / フェリチン / CRP / 鉄代謝 / 炎症性マーカー / 終末期患者予後 / 鉄代謝機構 / 予後予測モデル / フェロポルチン / 血清フェリチン値 / 耐性克服 / 肺小細胞癌 / オラパリブ / Ｐａｒｐ阻害剤 / シスプラチン耐性 / PARP阻害剤 / ＰＡＲＰ阻害剤 / 小細胞肺癌 / thymidylate synthase / 耐性化 / ペメトレキセド / 耐性 / EGFR-TKI / pemetrexed / 非小細胞肺癌 / 遺伝子診断・治療 / ドラッグデリバリー / 分子標的 / がん / 脳腫瘍 / 胆管がん / 膵がん / 腫瘍 / ペプチド / (1)含鉄蛋白質 / 体内被曝 / 含鉄蛋白 / ラット / プリミティブマントル正規化微量原素パターン / 発癌 / 鉄 / 生体内被曝 / ラジウム / 悪性中皮腫 / 非閉塞性肺疾患癌 / mTOR阻害薬 / BIBW2552 / JAK1/2阻害薬 / everolimus / ｍTOR阻害薬 / 用量依存性 / gefitinib / AZD1480 / everolims / NNK / Ogg1ホモノックアウトマウス / bevacizumab / cetuximab / JAK-1/2 inhibitors / everolimus (mTOR阻害薬), / afatinib / EGFR遺伝子改変マウス / ヴィノレルビン / L858R / 動物実験モデル / ジェムサイタビン / ドセタキセル / 上皮成長因子受容遺伝子異 / SP-C / 非喫煙 / ZD6474 / 分子標的化学予防 / 血管内皮細胞成長因子受容体 / 肺腺癌 / バンデタニブ / 化学予防 / 非喫煙者 / 腺癌 / (5)メチル化DNA / メチル化DNA / 血清遊離DNA / 早期診断 / 塵肺 / 肺線維症 / 癌 / 細胞障害性T細胞 / マイナー組織適合抗原 / 骨髄非破壊的幹細胞移植 / 自己末梢血幹細胞移植 / 同種末梢血幹細胞移植 / 移植片対白血病(GVL)効果 / 移植片対腫瘍(GVT)効果 / 進行肺癌 Less

Analysis of drug-resistant cells induced by molecular target agents and prevention of the resistancePrincipal Investigator
- Principal Investigator
  
  瀧川奈義夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcoma
- Principal Investigator
  
  山根弘路
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kawasaki Medical School
Elucidation of molecular pathogenesis and carcinogenesis in pulmonary large cell neuroendocrine carcinoma using patient derived organoids
- Principal Investigator
  
  深澤拓也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kawasaki Medical School
Overcoming treatment resistance based on metabolic properties of EGFR gene mutationsPrincipal Investigator
- Principal Investigator
  
  Takigawa Nagio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathway
- Principal Investigator
  
  Yamane Hiromichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kawasaki Medical School
Identification and overcoming specific signals in EGFR-TKI resistant lung cancerPrincipal Investigator
- Principal Investigator
  
  Takigawa Nagio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School
Combination therapy of parp inhibitor for overcoming small cell lung cancer drug-resistance
- Principal Investigator
  
  Minami Daisuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  独立行政法人国立病院機構岡山医療センター(臨床研究部)
  National Hospital Organization Nagoya Medical Center
Analysis of pemetrexed-resistant mechanism in EGFR mutation positive non-small cell lung cancer
- Principal Investigator
  
  Ochi Nobuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kawasaki Medical School
Development of tumor targeting technology in combination of tumor-homing peptide and nanoparticles
- Principal Investigator
  
  Kondo Eisaku
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Niigata University
  愛知県がんセンター(研究所)
Effects of molecular-targeted drugs on nonsmoking-related lung cancer modelsPrincipal Investigator
- Principal Investigator
  
  TAKIGAWA Nagio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School
Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Mechanism of progression from bronchioloalveolar carcinoma to invasive adenocarcinomaPrincipal Investigator
- Principal Investigator
  
  TAKIGAWA Nagio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School
  Okayama University
上皮成長因子受容体遺伝子変異陽性肺癌の根治治療開発を目指した動物実験モデルの樹立
- Principal Investigator
  
  木浦勝行
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice
- Principal Investigator
  
  KIURA Katsuyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Mechanism of carcinogenesis from pulmonary atypical adenomatous hyperplasia to adenocarcinomaPrincipal Investigator
- Principal Investigator
  
  TAKIGAWA Nagio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Early detection of lung cancer using aberrant promoter hypermethylation in serum DNA from patients with silicosis
- Principal Investigator
  
  TABATA Masahiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
進行肺癌に対する同種末梢血幹細胞移植:移植片対腫瘍効果とCTLの誘導
- Principal Investigator
  
  原田実根
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University

[Book] Therapy and Prognosis2009
- Author(s)
  Kiura K, Takigawa N, Segawa Y
- Total Pages
  609
- Publisher
  Springer, Methods of Cancer Diagnosis
- Data Source
  KAKENHI-PROJECT-18590851
[Book] Methods of Cancer Diagnosis, Therapy and Prognosis2009
- Author(s)
  Katsuyuki Kiura, Nagio Takigawa, Yoshihiko Segawa
- Total Pages
  609
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18590851
[Book] Advanced Non-Small Cell Lung Carcinoma Acquired Resistance to Gefitinib (Methods of Cancer Diagnosis, Therapy and Prognosis : General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma (Methods of Cancer Diagnosis, Therapy and Prognosis)2008
- Author(s)
  Kiura K, Takigawa N, Segawa Y
- Publisher
  Hayat, M. A. (EDT)
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Patient-derived tumoroid models of pulmonary large-cell neuroendocrine carcinoma: a promising tool for personalized medicine and developing novel therapeutic strategies2024
- Author(s)
  Yokota Etsuko、Iwai Miki、Yukawa Takuro、Naomoto Yoshio、Haisa Minoru、Monobe Yasumasa、Takigawa Nagio、Fukazawa Takuya、Yamatsuji Tomoki
- Journal Title
  
  Cancer Letters
  
  Volume: 588 Pages: 216816-216816
- DOI
  10.1016/j.canlet.2024.216816
- Data Source
  KAKENHI-PROJECT-21K08191, KAKENHI-PROJECT-23K24423
[Journal Article] Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma2024
- Author(s)
  Iwai Miki、Yokota Etsuko、Ishida Yuta、Yukawa Takuro、Naomoto Yoshio、Monobe Yasumasa、Haisa Minoru、Takigawa Nagio、Fukazawa Takuya、Yamatsuji Tomoki
- Journal Title
  
  Human Cell
  
  Volume: 37 Issue: 4 Pages: 1-11
- DOI
  10.1007/s13577-024-01060-3
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics2023
- Author(s)
  Ochi Nobuaki、Takeyama Masami、Miyake Noriko、Fuchigami Maki、Yamane Hiromichi、Fukazawa Takuya、Nagasaki Yasunari、Kawahara Tatsuyuki、Nakanishi Hidekazu、Takigawa Nagio
- Journal Title
  
  Experimental Cell Research
  
  Volume: 424 Issue: 1 Pages: 113503-113503
- DOI
  10.1016/j.yexcr.2023.113503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] Prospective exosome-focused translational research for afatinib (EXTRA) study of patients with nonsmall cell lung cancer harboring EGFR mutation: an observational clinical study2023
- Author(s)
  Takata Saori、Morikawa Kei、Tanaka Hisashi、Itani Hidetoshi、Ishihara Masashi、Horiuchi Kazuya、Kato Yasuhiro、Ikemura Shinnosuke、Nakagawa Hideyuki、Nakahara Yoshiro、Seki Yoshitaka、Bessho Akihiro、Takahashi Nobumasa、Hayashi Kentaro、Endo Takeo、Takeyama Kiyoshi、Maekura Toshiya、Takigawa Nagio、et al.
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 15 Pages: 1-14
- DOI
  10.1177/17588359231177021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191, KAKENHI-PROJECT-23K21392
[Journal Article] First and repeat rebiopsy for detecting EGFR T790M mutation in non-small-cell lung cancer: CS-Lung-003 prospective observational registry study2022
- Author(s)
  Kudo Kenichiro、Nishii Kazuya、Makimoto Go、Ishikawa Nobuhisa、Tsubata Yukari、Kodani Masahiro、Fujimoto Nobukazu、Yamasaki Masahiro、Kubota Tetsuya、Takigawa Nagio、Fujitaka Kazunori、Kanaji Nobuhiro、Shibayama Takuo、Itano Junko、Ando Chihiro、Hotta Katsuyuki、Kiura Katsuyuki
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 148 Issue: 8 Pages: 1869-1877
- DOI
  10.1007/s00432-021-03893-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021
- Author(s)
  Nakagawa N, Miyake N, Ochi N, Yamane H, Takeyama M, Nagasaki Y, Ikeda T, Yokota E, Fukazawa T, Nakanishi H, Harada D, Kiura K, Takigawa N.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 409 Issue: 2 Pages: 112940-112940
- DOI
  10.1016/j.yexcr.2021.112940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] What can we learn from 3 phase III trials of ASCEND-4: ceritinib vs. platinum/pemetrexed with pemetrexed maintenance, PROFILE 1004: crizotinib vs. platinum/pemetrexed, and J-ALEX: alectinib vs. crizotinib?2017
- Author(s)
  Nobuaki Ochi, Nagio Takigawa
- Journal Title
  
  Translational Cancer Research
  
  Volume: 印刷中 Issue: S3 Pages: S515-S518
- DOI
  10.21037/tcr.2017.04.20
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830118
[Journal Article] Effects of (−)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017
- Author(s)
  Honda Y, Takigawa N, Ichihara E, Ninomiya T, Kubo T, Ochi N, Yasugi M, Murakami T, Yamane H, Tanimoto M, Kiura K.
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 71 Issue: 6 Pages: 505-512
- DOI
  10.18926/AMO/55587
- NAID
  120006370714
- URL
  https://ousar.lib.okayama-u.ac.jp/55587
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09594
[Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.2016
- Author(s)
  Ochi N, Isozaki H, Takeyama M, Singer JW, Yamane H, Honda Y, Kiura K, Takigawa N.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 344 Issue: 2 Pages: 194-200
- DOI
  10.1016/j.yexcr.2016.05.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K09594
[Journal Article] The Role of STAT3 in Non-Small Cell Lung Cancer.2014
- Author(s)
  Harada D, Takigawa N, Kiura K.
- Journal Title
  
  Cancers
  
  Volume: 26 Issue: 2 Pages: 708-722
- DOI
  10.3390/cancers6020708
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591182
[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014
- Author(s)
  Ochi N, Takigawa N, Harada D, Yasugi M, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 322 Issue: 1 Pages: 168-177
- DOI
  10.1016/j.yexcr.2014.01.007
- NAID
  120005517858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] The Role of STAT3 in Non-Small Cell Lung Cancer.2014
- Author(s)
  Harada D, Takigawa N, Kiura K.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 6 Pages: 708-722
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.2014
- Author(s)
  Yasugi M, Takigawa N, Ochi N, Ohashi K, Harada D, Ninomiya T, Murakami T, Honda Y, Ichihara E, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 326 Issue: 2 Pages: 201-209
- DOI
  10.1016/j.yexcr.2014.04.012
- NAID
  120005526613
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model2014
- Author(s)
  Murakami Toshi, Takigawa Nagio, Ninomiya Takashi, Ochi Nobuaki, Yasugi Masaaki, Honda Yoshihiro, Kubo Toshio, Ichihara Eiki, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 83 Issue: 1 Pages: 30-36
- DOI
  10.1016/j.lungcan.2013.10.011
- NAID
  120005473065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene.2014
- Author(s)
  Isozaki H, Yasugi M, Takigawa N, Hotta K, Ichihara E, Taniguchi A, Toyooka S, Hashida S, Sendo T, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 2014 Issue: 10 Pages: 963-968
- DOI
  10.1093/jjco/hyu110
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.2014
- Author(s)
  Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S.
- Journal Title
  
  J Natl Cancer Inst
  
  Volume: 106 Issue: 1
- DOI
  10.1093/jnci/djt338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-25670399, KAKENHI-PROJECT-26290039
[Journal Article] Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer model.2013
- Author(s)
  Ninomiya T, Takigawa N, Ichihara E, Ochi N, Murakami T, Honda Y, Kubo T, Minami D, Kudo K, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 12 Issue: 5 Pages: 589-597
- DOI
  10.1158/1535-7163.mct-12-0885
- NAID
  120005359109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy.2013
- Author(s)
  Kubo T, Takigawa N, Osawa M, Harada D, Ninomiya T, Ochi N, Ichihara E, Yamane H, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 1 Pages: 78-84
- DOI
  10.1111/cas.12045
- NAID
  120005311967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model.2013
- Author(s)
  Hayakawa H, Ichihara E, Ohashi K, Ninomiya T, Yasugi M, Takata S, Sakai K, Matsumoto K, Takigawa N, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 11 Pages: 1440-1446
- DOI
  10.1111/cas.12284
- NAID
  120005468272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24300329
[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013
- Author(s)
  Takeda H, Takigawa N, Ohashi K, Minami D, Kataoka I, Ichihara E, Ochi N, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Issue: 4 Pages: 417-427
- DOI
  10.1016/j.yexcr.2012.12.018
- NAID
  120005359097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.2013
- Author(s)
  Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S.
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Issue: 10 Pages: 3051-3061
- DOI
  10.1158/0008-5472.can-12-4136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23592061
[Journal Article] Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.2013
- Author(s)
  Takeda H, Takigawa N, Ohashi K, Minami D, Kataoka I, Ichihara E, Ochi N, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 319 Issue: 2 Pages: 417-423
- DOI
  10.1158/1541-7786.mcr-12-0401
- NAID
  120005359097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23651046, KAKENHI-PROJECT-24310042, KAKENHI-PLANNED-23114010
[Journal Article] Impact of physical size on gefitinib efficacy in patients with non-small cell lung cancer harboring EGFR mutations.2013
- Author(s)
  Ichihara E, Hotta K, Takigawa N, Kudo K, Kato Y, Honda Y, Hayakawa H, Minami D, Sato A, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 81 Issue: 3 Pages: 435-439
- DOI
  10.1016/j.lungcan.2013.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013
- Author(s)
  Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
- Journal Title
  
  Molecule Cancer Therapeutics
  
  Volume: 12 Issue: 8 Pages: 1616-1628
- DOI
  10.1158/1535-7163.mct-12-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25112716, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-25670263
[Journal Article] Selective cyclooxygenase-2 inhibitor prevents cisplatin-induced tumorigenesis in A/J mice.2012
- Author(s)
  Okada T, Takigawa N, Kishino D, Katayama H, Kuyama S, Sato K, Mimoto J, Ueoka H, Tanimoto M, Kiura K.
- Journal Title
  
  Acta Med Okayama.
  
  Volume: 66 Pages: 1795-1802
- NAID
  120004247096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] STAT3 expression in activating EGFR-driven adenocarcinoma of the lung2012
- Author(s)
  Takata Saburo, Takigawa Nagio, Segawa Yoshihiko, Kubo Toshio, Ohashi Kadoaki, Kozuki Toshiyuki, Teramoto Norihiro, Yamashita Motohiro, Toyooka Shinichi, Tanimoto Mitsune, Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 75 Issue: 1 Pages: 24-29
- DOI
  10.1016/j.lungcan.2011.05.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590995, KAKENHI-PROJECT-23390221
[Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.2012
- Author(s)
  Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T..
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Issue: 3 Pages: 510-4
- DOI
  10.1111/j.1349-7006.2011.02180.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659432
[Journal Article] Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.2012
- Author(s)
  Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Pages: 510-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659432
[Journal Article] JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation2012
- Author(s)
  Harada D, Takigawa N, Ochi N, Ninomiya T, Yasugi M, Kubo T, Takeda H, Ichihara E, Ohashi K, Takata S, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Issue: 10 Pages: 1795-1802
- DOI
  10.1111/j.1349-7006.2012.02363.x
- NAID
  120005311974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182
[Journal Article] Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells2011
- Author(s)
  Rai K, Takigawa N, Ito S, Kashihara H, Ichihara E, Yasuda T, Shimizu K, Tanimoto M, Kiura K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 10 Pages: 1720-1727
- NAID
  130004903196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells2011
- Author(s)
  Kammei Rai, Takigawa Nagio, Ito Sachio, Kashihara Hiromi, Ichihara Eiki, Yasuda Tatsuji, Shimizu Kenji, Tanimoto Mitsune, Kiura Katsuyuki
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 10 Issue: 9 Pages: 1720-1727
- DOI
  10.1158/1535-7163.mct-11-0220
- NAID
  120005232489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590995
[Journal Article] Establishment of pemetrexed-resistant non-small cell lung cancer cell lines2011
- Author(s)
  Zhang D, Ochi N, Takigawa N, Tanimoto I, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Lett
  
  Volume: 309 Issue: 2 Pages: 228-235
- DOI
  10.1016/j.canlet.2011.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221
[Journal Article] Medical treatment of mesothelioma: anything new?2011
- Author(s)
  Takigawa N, Kiura K, Kishimoto T
- Journal Title
  
  Curr Oncol Rep
  
  Volume: 13 Issue: 4 Pages: 265-71
- DOI
  10.1007/s11912-011-0172-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659432
[Journal Article] Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concurrent thoracic radiotherapy in locally advanced non-small-cell lung cancer : OLCSG 00072010
- Author(s)
  Segawa Y, Kiura K, Takigawa N, et al.
- Journal Title
  
  J Clin Oncol.
  
  Volume: 28 Pages: 3299-3306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659209
[Journal Article] Effects of vandetanib on lung adenocarcinoma cells emerging an acquired EGFR T790M mutation in vivo. Cancer Res. 69(12) : 5091-8, 20092009
- Author(s)
  Ichihara E, Ohashi K, Takigawa N, Osawa M, Ogino A, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Res 69
  
  Pages: 5091-5098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659209
[Journal Article] Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1 -(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice2009
- Author(s)
  Kishino D, Kiura K, Takigawa N, Katayama H, Kuyama S, Sato K, Okada T, Ohashi K, Tanimoto M
- Journal Title
  
  Lung Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article]2009
- Author(s)
  木浦勝行瀧川奈義夫
- Journal Title
  
  がん化学療法・分子標的治療update(中外医学社)
  
  Pages: 317-323
- Data Source
  KAKENHI-PROJECT-21659209
[Journal Article] Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo.2009
- Author(s)
  Ichihara E, Ohashi K, Takigawa N, Osawa M, Ogino A, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Research 69
  
  Pages: 5091-5098
- NAID
  130004505698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590995
[Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.2009
- Author(s)
  Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K
- Journal Title
  
  Cancer Res 69
  
  Pages: 7088-7095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659209
[Journal Article] Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer2009
- Author(s)
  Hosokawa S, Toyooka S, Fujiwara Y, Tokumo M, Soh J, Takigawa N, Hotta K, Yoshino T, Date H, Tanimoto M, Kiura K
- Journal Title
  
  Lung Cancer (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer.2009
- Author(s)
  Hosokawa S, Toyooka S, Fujiwara Y, Tokumo M, Soh J, Takigawa N, Hotta K, Yoshino T, Date H, Tanimoto M, Kiura K.
- Journal Title
  
  Lung Cancer 66
  
  Pages: 107-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590995
[Journal Article] Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice2009
- Author(s)
  Kishino D, Kiura K, Takigawa N., et al
- Journal Title
  
  Lung Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Chemopreventive effects of gefitinib on nonsmoking-related lung tumorigenesis in activating epidermal growth factor receptor transgenic mice.2009
- Author(s)
  Ohashi K, Takigawa N, Osawa M, Ichihara E, Takeda H, Kubo T, Hirano S, Yoshino T, Takata M, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Research 69
  
  Pages: 7088-7095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590995
[Journal Article] GGOを呈する病変の分子生物学的検討2009
- Author(s)
  瀧川奈義夫, 木浦勝行
- Journal Title
  
  日本胸部臨床 68
  
  Pages: 131-138
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Effects of vandetanib on lung adenocarcinoma cells emerging an acquired EGFR T790M mutation2009
- Author(s)
  Ichihara E, Ohashi K, Takigawa N, Osawa M, Ogino A, Tanimoto M, Kiura K
- Journal Title
  
  in vivo Cancer Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice.2009
- Author(s)
  Kishino D, Kiura K, Takigawa N, Katayama H, Kuyama S, Sato K, Okada T, Ohashi K, Tanimoto M
- Journal Title
  
  Lung Cancer 65
  
  Pages: 284-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659209
[Journal Article] Impact of HER2 gene and protein status on the treatment outcome of cisplatin-based chemoradiotherapy for locally advanced non-small cell lung cancer2008
- Author(s)
  Kuyama s, Hotta K, Tabata M, Segawa Y, Fujiwara Y. Takigawa N. Kiura K, Deoka H, Eguchi K. Taniioto M.
- Journal Title
  
  J Thorac Oncol 3
  
  Pages: 477-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Aberrant promoter hypermethylation in serum DNA from patients with silicosis2008
- Author(s)
  梅村茂樹、藤本伸一、平木章夫、玄馬顕一、瀧川奈義夫、藤原慶一、藤井昌学、梅村啓史、佐藤守、田端雅弘、上岡博、木浦勝行、岸本卓巳、谷本光音
- Journal Title
  
  Carcinogenesis 第29巻
  
  Pages: 1845-1849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590852
[Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.2007
- Author(s)
  Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, et. al.
- Journal Title
  
  Cancer Research 67
  
  Pages: 7807-7814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation.2007
- Author(s)
  Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, et al.
- Journal Title
  
  Cancer Science 98巻・3号
  
  Pages: 357-363
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Activation of downstream epidermal growth factor receptor(EGFR)signaling provides gefitinib-resistance in cells carrying EGFR mutation2007
- Author(s)
  Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, Tabata M, Takata M, Kiura K, Tanimoto M
- Journal Title
  
  Cancer Sci 98
  
  Pages: 357-363
- NAID
  10019481589
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. Lung Cancer.2007
- Author(s)
  Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, Tabata M, Tanimoto M:
- Journal Title
  
  Lung Cancer 58
  
  Pages: 15-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.2007
- Author(s)
  Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, Takata M, Kiura K, Tanimoto M
- Journal Title
  
  Cancer Res. 67
  
  Pages: 7807-7814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.2007
- Author(s)
  Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, et. al.
- Journal Title
  
  Lung Cancer 58
  
  Pages: 15-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Mutation of the epidermal growth factor receptor gene in the development of adenocarcinoma of the lung.2007
- Author(s)
  Kozuki T, Hisamoto A, Tabata M, Takigawa N, et. al.
- Journal Title
  
  Lung Cancer 58
  
  Pages: 30-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Mutation of the epidermal growth factor receptor gene in the development of adenocarcinoma of the lung2007
- Author(s)
  Kozuki T, Hisamoto A, Tabata M, Takigawa N, Kiura K, Segawa Y, Nakata M, Mandai K, Eguchi K, Ueoka H, Tanimoto M.
- Journal Title
  
  Lung Cancer 58
  
  Pages: 30-35
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation2007
- Author(s)
  Uchida A, Hirano S, Kitao H, Ogino A, Rai K, Toyooka S, Takigawa N, Tabata M, Takata M, Kiura K, Tanimoto M
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 357-363
- NAID
  10019481589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590895
[Journal Article] Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line2007
- Author(s)
  Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, Takigawa N, Takata M, Kiura K, Tanimoto M
- Journal Title
  
  Cancer Res 67
  
  Pages: 7807-7814
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice2007
- Author(s)
  Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, Tanimoto M
- Journal Title
  
  Lung Cancer 58
  
  Pages: 15-20
- Data Source
  KAKENHI-PROJECT-18590851
[Journal Article] Second primary cancer in survivors following concurrent chemoradiation for locally advanced non-small-cell lung cancer.2006
- Author(s)
  Takigawa N et al.
- Journal Title
  
  British Journal of Cancer 95巻・9号
  
  Pages: 1142-1144
- Data Source
  KAKENHI-PROJECT-18590851
[Presentation] トラベクテジンによる化学療法が効果的であったFUS/CHOP融合遺伝子陽性粘液型脂肪肉腫患者4症例2024
- Author(s)
  切士博仁、山根弘路、砂田有哉、三村彩香、市山成彦、河原辰由樹　長﨑泰有、小坂陽子、越智宣昭、中西秀和、瀧川奈義夫1)
- Organizer
  第21回日本臨床腫瘍学会学術集会（JSMO2024）
- Data Source
  KAKENHI-PROJECT-22K09436
[Presentation] EGFRエクソン19欠失とエクソン21 L858R遺伝子変異を有する肺癌細胞株のマルチオミクス解析2023
- Author(s)
  越智宣昭, 竹山雅美, 三宅規子, 山根弘路, 深澤拓哉, 長﨑泰有, 河原辰由樹, 中西秀和, 瀧川奈義夫
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis2023
- Author(s)
  Nagio Takigawa, Noriko Miyake, Nobuaki Ochi, Masami Takeyama, Hideko Isozaki, Eiki Ichihara, Hiromichi Yamane, Takuya Fukazawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Hidekazu Nakanishi, Katsuyuki Kiura
- Organizer
  American College of CHEST Physician 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] EGFR遺伝子変異肺癌におけるROR1標的治療の基礎的検討2021
- Author(s)
  三宅規子、越智宣昭、中川　望、竹山雅美、山根弘路、長﨑泰有、岩井美樹、横田悦子、深澤拓也、瀧川奈義夫
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] 進行期がん患者における血清炎症性マーカーおよび血清ヘプシジン25濃度と患者予後との関係性について2020
- Author(s)
  山根弘路　越智宜昭　中西秀和　小原弘之　六原純子　瀧川奈義夫
- Organizer
  第25回　日本緩和医療学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] 終末期肺がん患者予後に影響する血清炎症性マーカーの検討と新たな予後予測指標の提案2020
- Author(s)
  山根弘路　越智宜昭　中川望　長崎康有　河原辰由樹　市山成彦　田岡征高　三村彩香　小原弘之　瀧川奈義夫
- Organizer
  第61回　日本肺癌学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] ドライバーオンコジーンを有する肺がんに対するエピガロカテキンガレート（EGCG)の効果2017
- Author(s)
  本多宣裕, 瀧川奈義夫, 越智宣昭, 二宮崇, 八杉昌幸, 久保寿夫, 磯崎英子, 市原英基, 堀田勝幸, 山根弘路, 谷本光音, 木浦勝行
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09594
[Presentation] EGFR遺伝子変異を有する肺癌におけるpemetrexed耐性機構とgefitinib感受性に及ぼす影響2016
- Author(s)
  越智　宣昭、張　丹、本多　宣裕、山根弘路、谷本光音、木浦勝行、瀧川奈義夫
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-26830118
[Presentation] PacritinibによるJAK2を介したEGFR-TKI耐性の克服2016
- Author(s)
  越智宣昭、山根弘路、本多宣裕、磯崎英子、木浦勝行、瀧川奈義夫
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡サンパレス(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-16K09594
[Presentation] Both programmed cell death protein 1 and programmed death-ligand 1 molecules can be expressed on the cell surface of small-cell lung cancer2015
- Author(s)
  Hiromichi Yamane1, Hideko Isozaki2, Nobuaki Ochi1, Kenichiro Kudo2, Yoshihiro Honda1, Tomoko Yamagishi1, Toshio Kubo2, Katsuyuki Kiura2, Nagio Takigawa1.Hiromichi Yamane1, Hideko Isozaki2, Nobuaki Ochi1, Kenichiro Kudo2, Yoshihiro Honda1, Tomoko Yamagishi1, Toshio Kubo2, Katsuyuki Kiura2, Nagio Takigawa1.
- Organizer
  The 106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-20
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene2014
- Author(s)
  Isozaki H, Ichihara E, Yasugi M, Ochi N, Hotta K, Takigawa N, Sendo T, Tanimoto M, Kiura K.
- Organizer
  Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  USA, San Diego, San Diego Convention Center
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-24591182
[Presentation] ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene.2014
- Author(s)
  Hideko Isozaki, Eiki Ichihara, Masayuki Yasugi, Ocihi Nobuaki, Katsuyuki Hotta, Nagio Takigawa, Toshiaki Sendo, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  The 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA. USA
- Year and Date
  2014-04-08
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Novel germline G660D mutation in HER2 gene detected by whole-exome sequencing can predispose a patient to developing familial lung adenocarcinoma2014
- Author(s)
  Hiromasa Yamamoto, Koichiro Higasa, Masakiyo Sakaguchi, Kazuhiko Shien, Junichi Soh, Koichi Ichimura, Masashi Furukawa, Shinsuke Hashida, Kazunori Tsukuda, Nagio Takigawa, Keitaro Matsuo, Katsuyuki Kiura, Sinichiro Miyoshi, Fumihiko Matsuda, Shinichi Toyooka
- Organizer
  The 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, CA. USA
- Year and Date
  2014-04-09
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Epidermal growth factor receptor signaling conferred acquired crizotinib resistance to a non-small cell lung cancer cell line harboring the SLC34A2-ROS1 fusion gene2014
- Author(s)
  Kato Y, Ohashi K, Ichihara E, Isozaki H, Kudo K, Minami D, Kubo T, Sato A, Hotta K, Tabata M, Takigawa N, Tanimoto M, Kiura K
- Organizer
  Annual Meeting of the European Society for Medical Oncology
- Place of Presentation
  Spain, Madrid, Feria de Madrid
- Year and Date
  2014-09-28
- Data Source
  KAKENHI-PROJECT-24591182
[Presentation] PTEN deficient lung cancer cells are sensitive to the combination of olaparib with cisplatin through suppressing DNA damage signaling2013
- Author(s)
  Minami Daisuke, Takigawa Nagio, Takeda Hiromasa, Takata Minoru, Ochi Nobuaki , Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  AACR Annual Meeting 2013
- Place of Presentation
  Washington Convention Center, Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-24591182
[Presentation] EGFR遺伝子改変マウスに対するJAK1/2阻害剤(AZD1480)の検討2012
- Author(s)
  村上斗司、瀧川奈義夫、他
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-24591182
[Presentation] Effect of AZD1480 on lung tumor in transgenic mice carrying activating EGFR mutation2012
- Author(s)
  Toshi Murakami, Nagio Takigawa, Takashi Ninomiya, Nobuhiro Honda, Hideko Isozaki, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Afatinib prolonged survival in EGFR-driven lung cancer model compared to gefitinib2012
- Author(s)
  Takashi Ninomiya, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura, Nagio Takigawa, Nobuaki Ochi, Masayuki Yasugi, Daijiro Harada.
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  McCormick Place in Chicago, Illinois
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Effect of everolimus on lung tumorigenesis in transgenic mice carrying activating EGFR mutation2011
- Author(s)
  Yasugi Masayuki, Takigawa Nagio, Ochi Nobuaki, Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] Effect of everolimus on lung tumorigenesis in transgenic mice carrying activating EGFR mutation2011
- Author(s)
  Yasugi Masayuki, Takigawa Nagio, Ochi Nobuaki, Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tabata Masahiro, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] エクソン19欠失EGFR遺伝子変異陽性肺癌モデルに対するアファチニブの効果2011
- Author(s)
  二宮崇, 瀧川奈義夫, 村上斗司, 本多宣裕, 南大輔, 越智宣昭, 八杉昌幸, 久保寿夫, 市原英基, 谷本光音, 木浦勝行
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪市
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] Effect of everolimus on lung tumorigenesis in transgenic mice carrying activating EGFR mutation2011
- Author(s)
  Yasugi M, Takigawa N, Kiura K, et al
- Organizer
  第102回米国癌学会(AACR)
- Place of Presentation
  オーランド,フロリダ,アメリカ合衆国
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-21659209
[Presentation] Role of ERK reactivation mediated by Src in acquired resistance to gefitinib in non-small cell lung cancer with EGFR mutation2011
- Author(s)
  Ochi N, Takigawa N, Ohashi K, Takeda H, Fujii M, Kubo T, Ichihara E, Hotta K, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Vascular endothelial growth factor receptor tyrosine kinase inhibitor inhibited mutated epidermal growth factor receptor-driven tumors ex vivo and in vivo2011
- Author(s)
  Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Ninomiya T, Takigawa N, Harita S, Nakata Y, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] ERK reactivation mediated by SRC in acquired resistance to gefitinib in non-small cell lung cancer with EGFR mutation2011
- Author(s)
  Ochi Nobuaki, Takigawa Nagio, Yasugi Masayuki, Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tabata Masahiro, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] エクソン19欠失EGFR遺伝子変異陽性肺癌モデルに対するアファチニブの効果2011
- Author(s)
  二宮崇, 瀧川奈義夫, 村上斗司, 本多宣裕, 南大輔, 越智宣昭, 八杉昌幸, 久保寿夫, 市原英基, 谷本光音, 木浦勝行
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] JAK2/STAT3 induces erlotinib-resistance in lung cancer cells harboring EGFR-activating mutations2011
- Author(s)
  Harada D, Takigawa N, Onashi K, Tchihara E, Toshio Kubo T, Takeda H, Kashihara H, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Multiple molecular targeting effects by miR-7 in EGFR tyrosine kinase inhibitor-resistant lung cancer xenograft models2011
- Author(s)
  Kammei Rai, Takigawa Nagio, Ito Sachio, Kiura Katsuyuki, Yasuda Tatsuji, Shimizu Kenji, Tanimoto Mitsune
- Organizer
  102nd Annual Meeting of American Association for Cancer Research
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] ERK reactivation mediated by SRC in acquired resistance to gefitinib in non-small cell lung cancer with EGFR mutation2011
- Author(s)
  Ochi Nobuaki, Takigawa Nagio, Yasugi Masayuki, Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tabata Masahiro, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] JAK2/STAT3 induces erlotinib-resistance in lung cancer cells harboring EGFR-activating mutations2011
- Author(s)
  Harada Daijiro, Takigawa Nagio, Ohashi Kadoaki, Ichihara Eiki, Kubo Toshio, Takeda Hiromasa, Kashihara Hiromi, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  102nd Annual Meeting of American Association for Cancer Research
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] Effect of afatinib on lung cancer burden induced by an exon 19 EGFR mutation in transgenic mice2011
- Author(s)
  Ninomiya T, Takigawa N, Kubo T, Yasugi M, Honda Y, Minami D, Murakami T, Ichihara E, Tanimoto M, Kiura K
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orange County Convention Center, Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23390221
[Presentation] Lipofection of the designed plasmid expressing microRNA-7 has antitumor effect in gefitinib-resistant lung adenocarcinoma in vivo.2010
- Author(s)
  Rai K, Takigawa N, Ito S, Kashihara H, Ichihara E, Kiura K, Yasuda T, Shimizu K, Tanimoto M.
- Organizer
  米国癌学会
- Place of Presentation
  ワシントンDC
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] Chemopreventive effect of vandetanib on tumorigenesis in a mouse model of non-smoking related lung cancer AACR Annual Meeting 20092009
- Author(s)
  Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Fujii M, Kashihara H, Takigawa N, Tanimoto , Kiura K
- Organizer
  Biological Mechanisms and Molecular Markers of Prevention(米国癌学会総会, ミニシンポジウム)
- Place of Presentation
  Colorado Convention Center, Denver, CO Abstract#4783 Minisymposium
- Data Source
  KAKENHI-PROJECT-19590895
[Presentation] The role of STAT3 in the progression of lung adenocarcinoma2009
- Author(s)
  Takata S, Takigawa N, Kiura K, et al.
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21590995
[Presentation] Chemopreventive effect of vandetanib on tumorigenesis in a mouse model of non-smoking related lung cancer2009
- Author(s)
  Kubo T, Ohashi K, Osawa M, Takeda H, Ichihara E, Fujii M, Kashihara H, Takigawa N, Tanimoto, Kiura K.
- Organizer
  米国癌学会総会 AACR Annual Meeting 200 Abstract#4783 Minisymposium
- Place of Presentation
  Colorado Convention Center, Denver, CO, USA
- Data Source
  KAKENHI-PROJECT-21659209
[Presentation] すりガラス陰影を伴う肺腺癌の進展におけるEGFRシグナルの関与発表者2008
- Author(s)
  高田三郎、瀧川奈義夫、大橋圭明、畝川芳彦、山下素弘、寺本典弘、新海哲、上月稔幸、堀田勝幸、田端雅弘、木浦勝行、谷本光音
- Organizer
  第49回日本肺癌学会総会
- Year and Date
  2008-11-13
- Data Source
  KAKENHI-PROJECT-18590851
[Presentation] すりガラス陰影を伴う肺腺癌の進展におけるEGFRシグナルの関与2008
- Author(s)
  高田三郎, 瀧川奈義夫, 大橋圭明, 畝川芳彦, 山下素弘, 寺本典弘, 新海哲, 上月稔幸, 堀田勝幸, 田端雅弘, 木浦勝行, 谷本光音
- Organizer
  第49回日本肺癌学会総会
- Place of Presentation
  北九州市
- Year and Date
  2008-11-13
- Data Source
  KAKENHI-PROJECT-18590851
[Presentation] Chemopreventive effect of gefitinib on tumorgenesis in smoking unrelated lung cancer mouse model AACR Annual Meeting 20082008
- Author(s)
  Ohashi K, Kiura K, Osawa M, Takeda H, Kubo T, Ichihara E, Takigawa N, Hirano S, Tanimoto M, Takata M
- Organizer
  米国癌学会総会, ミニシンポジウム
- Place of Presentation
  San Diego, CA Abstract # 4186 Minisymposium
- Data Source
  KAKENHI-PROJECT-19590895
[Presentation] Transgenic mice with mouse EGFR mutation developed lung adenocarcinoma.2007
- Author(s)
  Ohashi K, Rai K, Kiura K, Osawa M, Hirano S, Fujiwara Y, Yoshino T, Takigawa N, Takata M, Tanimoto M
- Organizer
  2007 AACR Annual Meeting 米国癌学会
- Place of Presentation
  Los Angeles, CA, 米国
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-19590895
[Presentation] Emergence of EGFR T790M mutation during chronic exposure to gefitinib in a NSCLC cell line2007
- Author(s)
  Ogino A, Kitao H, Hirano S, Uchida A, Takigawa N, Kiura K, Tanimoto M
- Organizer
  98^<th> Annual Meeting of American Association for Cancer Research
- Place of Presentation
  LA, USA
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-18590851
[Presentation] Emergence of EGFR T790M mutation during chronic exposure to gefitinib in a NSCLC cell line.2007
- Author(s)
  34. Ogino A, Kitao H, Hirano S, Uchida A, Takigawa N, et. al.
- Organizer
  97rd Annual Meeting of American Association for Cancer Research
- Place of Presentation
  LA, USA
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-18590851
[Presentation] Early occurrence of epidermal growth factor receptor Mutation in lung adenocarcinoma: Comparison between pulmonary atypical adenomatous hyperplasia and adenocarcinoma2006
- Author(s)
  Kozuki T, Hisamoto A, Takigawa N, Tabata M, Segawa Y, Nakata M, Umemura S, Ohashi K, Kiura K, Eguchi K, Ueoka H, Tanimoto M
- Organizer
  97^<th> Annual Meeting of American Association for Cancer Research
- Place of Presentation
  Washington DC, USA
- Year and Date
  2006-04-17
- Data Source
  KAKENHI-PROJECT-18590851

1. KIURA Katuyuki (10243502)

# of Collaborated Projects: 8 results

# of Collaborated Products: 81 results
2. OCHI Nobuaki (80611615)

# of Collaborated Projects: 8 results

# of Collaborated Products: 15 results
3. YAMANE Hiromichi (50624897)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
4. 中西秀和 (50309548)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. TAKATA Minoru (30281728)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. YOSHINO Tadashi (70183704)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. ICHIHARA Eiki (40549705)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
8. TABATA Masahiro (30243504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. Kondo Eisaku (30252951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TANIMOTO Yasushi (60284098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. HOTTA Katsuyuki (70379816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Eizo (80201672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TABAYASHI Takayuki (60624898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Koga Hironori (90268855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Minami Daisuke (80727470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 原田実根 (00019621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 品川克至 (00273988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 石丸文彦 (50284097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 竹中克斗 (30301295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 本多宣裕 (80746876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 國定俊之 (80346428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 深澤拓也 (20379845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 山辻知樹 (40379730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 佐久間哲史 (90711143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHIGEKI Umemura

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. TAKUMI Kishimoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 大橋圭明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 頼冠明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 高田三郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 大澤昌宏

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 武田洋昌

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 藤井昌学

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 久保寿夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 柏原宏美

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 原田大二郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 八杉昌幸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 藤田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takigawa Nagio 瀧川 奈義夫

TAKIGAWA Nagio 瀧川 奈義夫

滝川 奈義夫 タキガワ ナギオ

瀧川 奈義夫 タキガワ ヤギオ

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Co-Researchers

Analysis of drug-resistant cells induced by molecular target agents and prevention of the resistancePrincipal Investigator

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Overcoming treatment resistance based on metabolic properties of EGFR gene mutationsPrincipal Investigator

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Identification and overcoming specific signals in EGFR-TKI resistant lung cancerPrincipal Investigator

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Effects of molecular-targeted drugs on nonsmoking-related lung cancer modelsPrincipal Investigator

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Mechanism of progression from bronchioloalveolar carcinoma to invasive adenocarcinomaPrincipal Investigator

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Takigawa Nagio 瀧川奈義夫

TAKIGAWA Nagio 瀧川奈義夫

滝川奈義夫タキガワナギオ

瀧川奈義夫タキガワヤギオ