HOSAKA TOSHIO 保坂利男

… Alternative Names

保坂利男ホサカトシオ

HOSAKA Toshio 保坂利男

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Researcher Number	60403698
Other IDs
Affiliation (Current)	2025: 静岡県立大学, 食品栄養科学部, 教授
Affiliation (based on the past Project Information) *help	2024: 静岡県立大学, 食品栄養科学部, 教授 2018 – 2019: 静岡県立大学, 食品栄養科学部, 教授 2016 – 2017: 杏林大学, 医学部, 講師 2014: 杏林大学, 医学部, 講師 2011 – 2013: 埼玉医科大学, 医学部, 講師 … More 2009 – 2010: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 2009: 徳島大学, 医学部・歯学部附属病院糖尿病対策センター, 助教 2007 – 2008: 徳島大学, 医学部・歯学部附属病院, 助教 2005: The University of Tokushima, Institute for Enzyme Research, Research Associate, 分子酵素学研究センター, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits / Eating habits, studies on eating habits / Applied health science Except Principal Investigator Pathological medical chemistry / Biomedical engineering/Biological material science / Digestive surgery / Biological Sciences
Keywords	Principal Investigator アディポカイン / 血糖値 / 不規則な食事 / 欠食 / 代謝学 / 脂肪肝 / ビリルビン / GOT / 肝機能障害 / GPT … More / インスリン抵抗性 / 糖尿病 / 乳酸 / 脂肪合成 / GLUT4 / 脂肪酸 / 細胞骨格 / トランスロケーション / glut4 / フディポカイン / 糖代謝 / 脂質代謝 / 高圧酸素療法 / 生活習慣病 … More Except Principal Investigator internalization / APS / ユビキチン化 / インスリン受容体 / ubiquitination / diabetes / signal transductor / insulin receptor / 糖毒性 / 血中遊離インスリン受容体 / 糖尿病 / シグナル伝達 / インスリン作用 / 慢性炎症 / 脂肪細胞 / 弾性 / 細胞外基質 / 抗癌剤 / サプリメント / Th2バランス / Th1 / 中心静脈栄養 / 経腸栄養 / 術後栄養 / 食道亜全摘術 / 食道癌 / ユビチキン化 / ノックアウトマウス Less

To clear the influences and search factors of fluctuational blood glucose by irregular meal patternPrincipal Investigator
- Principal Investigator
  
  保坂利男
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  University of Shizuoka
The investigation on the pathological significance for lactate in insulin resistance.Principal Investigator
- Principal Investigator
  
  HOSAKA TOSHIO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  University of Shizuoka
  Kyorin University
The investigation of the interaction between insulin sensitivity and fatty acidsPrincipal Investigator
- Principal Investigator
  
  TOSHIO Hosaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Kyorin University
  Saitama Medical University
Finding the novel anti-metabolic syndrome treatment by examining the mechanism of improvement for lipid metabolism with hyperbaric oxygen.Principal Investigator
- Principal Investigator
  
  HOSAKA Toshio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Saitama Medical University
  The University of Tokushima
細胞支持基盤の弾性調節による初代培養脂肪・肝臓・骨格筋細胞の長期間機能保持の試み
- Principal Investigator
  
  船木真理
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokushima
Effect of nutrition on immune system and postoperative course of the patients with esophageal cancer and anticancer effect of supplements
- Principal Investigator
  
  TANGOKU Akira, 宇山攻
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
APSノックアウトマウスは肥満によるインスリン抵抗性を回避できる
- Principal Investigator
  
  OBATA Toshiyuki, KISHI Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima

All 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2008 Other

All Journal Article Presentation

[Journal Article] Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study2019
- Author(s)
  Ishitobi Minori、Hosaka Toshio、Morita Naru、Kondo Ken、Murashima Toshitaka、Kitahara Atsuko、Takahashi Kazuto、Sumitani Yoshikazu、Tanaka Toshiaki、Yokoyama Toshihiko、Kondo Takuma、Ishida Hitoshi
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 149 Pages: 1-8
- DOI
  10.1016/j.diabres.2019.01.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] Novel mechanisms modulating palmitate-induced inflammatory factors in hypertrophied 3T3-L1 adipocytes by AMPK.2018
- Author(s)
  Morita N, Hosaka T, Kitahara A, MurashimaT, Onuma H, Sumitani Y, Takahashi K, Tanaka T, Kondo T, Ishida H
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: なし Pages: 1-11
- DOI
  10.1155/2018/9256482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] Metabolic Effects of Tofogliflozin are Efficiently Enhanced with Appropriate Dietary Carbohydrate Ratio and are Distinct from Carbohydrate Restriction.2018
- Author(s)
  Ito S, Hosaka T, Yano W, Itou T, Yasumura M, Shimizu Y, Kobayashi H, Nakagawa T, Inoue K, Tanabe S, Kondo T, Ishida H
- Journal Title
  
  physiological Reports
  
  Volume: なし Issue: 5 Pages: e13642-e13642
- DOI
  10.14814/phy2.13642
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] CSP1 modulates insulin sensitivity by attenuating GLUT4 vesicle docking with the plasma membrane2013
- Author(s)
  Bayasgalan Jambaldorj, Eri Terada, Toshio Hosaka, Yuka Kishuku, Yukiko Tomioka, Kaori Iwashima, Yohko Hirata, Kiyoshi Teshigawara, Chung Thi Kim Le, Tadahiko Nakagawa, Nagakatsu Harada, Tohru Sakai, Hiroshi Sakaue, Toshio Matsumoto, Makoto Funaki, Akira Takahashi　and Yutaka Nakaya1.
- Journal Title
  
  Journal of medical investigation
  
  Volume: 60(3-4) Pages: 197-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500994
[Journal Article] Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes2013
- Author(s)
  李勤凱
- Journal Title
  
  Molecular and cellular endocrinology
  
  Volume: 365 Issue: 1 Pages: 25-35
- DOI
  10.1016/j.mce.2012.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22616005, KAKENHI-PROJECT-24500994
[Journal Article] Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.2012
- Author(s)
  Sakai T, Shuto E, Taki T, Imamura H, Kioka M, Nakamoto A, Mizoguchi S, Amano S, Kawano Y, Nakamoto M, Tsutumi R, Hosaka T.
- Journal Title
  
  Journal of medical investigation
  
  Volume: 59(1-2) Pages: 95-101
- NAID
  130004465275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500994
[Journal Article] Extracts of Common Buckwheat Bran Prevent Sucrose Digestion2011
- Author(s)
  Hosaka T, et al
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 57 Issue: 6 Pages: 441-445
- DOI
  10.3177/jnsv.57.441
- NAID
  130002103056
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500685, KAKENHI-PROJECT-22700749, KAKENHI-PROJECT-22700750
[Journal Article] Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice2010
- Author(s)
  Kiyoshi Teshigawara, Toshio Hosaka, Miwa Yamaguchi, Eri Terada, Yuka kisyuku, Keiko Fukunaga, Yohko Hirata, Bayasgalan Jambaldorj, Nagakatsu Harada, Tohru Sakai and Yutaka Nakaya
- Journal Title
  
  The journal of medical investigation
  
  Volume: 57(3, 4) Pages: 224-231
- NAID
  130004465212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500685
[Presentation] 膵β―細胞におけるパルミチン酸誘導性炎症反応へのアスタキサンチンの効果とオートファジー機構の関与2020
- Author(s)
  北原敦子、高橋和人、村嶋俊隆、近藤健、石飛実紀、保坂利男、近藤琢磨、石田均、安田和基
- Organizer
  第23回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] アシル化グレリンは脂肪細胞を介してインスリン抵抗性を惹起する.2019
- Author(s)
  北原敦子, 高橋和人, 森田奈瑠, 近藤健, 石飛実紀, 村嶋俊隆, 近藤琢磨, 保坂利男, 石田均
- Organizer
  第22回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 血清の肝脂肪非侵襲マーカーの可能性;糖尿病患者において空腹時乳酸値と肝脂肪化マーカーとが関連する.2018
- Author(s)
  石飛実紀,保坂利男,森田奈瑠,近藤健,村嶋俊隆,高橋和人,炭谷由計,田中利明,近藤琢磨,石田均
- Organizer
  第33回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義―インスリン抵抗性非侵襲代謝マーカーとしての可能性.2018
- Author(s)
  石飛実紀，保坂利男，森田奈瑠，村嶋俊隆，小沼裕寿，高橋和人，炭谷由計，田中利明，近藤琢磨，石田均
- Organizer
  第61回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲代謝マーカーとしての可能性-.2018
- Author(s)
  石飛実紀、保坂利男、森田奈瑠、村嶋俊隆、小沼裕寿、炭谷由計、田中利明、近藤琢磨、石田均
- Organizer
  第115回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化3T3-L1脂肪細胞でのパルミチン酸誘導炎症性サイトカイン発現に対するAMPKの影響とその細胞内機構の検討.2018
- Author(s)
  森田奈瑠，保坂利男，北原敦子，村嶋俊隆，小沼裕寿，炭谷由計，田中利明，近藤琢磨，石田均
- Organizer
  第61回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲代謝マーカーとしての可能性-.2018
- Author(s)
  石飛実紀,保坂利男,森田奈瑠,近藤健,村嶋俊隆,高橋和人,炭谷由計,田中利明,近藤琢磨,石田均
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲タイヤマーカーとしての可能性-2018
- Author(s)
  石飛実紀、保坂利男、石本麻衣、近藤健、森田奈瑠、村嶋俊隆、小沼裕寿、炭谷由計、近藤琢磨、石田均
- Organizer
  第21回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞でのAMPK活性化が及ぼす炎症性サイトカイン発現に対する影響とその細胞内機構の検討2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、小沼裕寿、五林可織、炭谷由計、高橋和人、田中利明、近藤琢磨、石田均
- Organizer
  第32回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] The Effect of AMPK Activation on Inflammatory Cytokine in Mature Hypertrophied 3T3-L1 Adipocyte2017
- Author(s)
  Morita N, Hosaka T, Kitahara A, Murashima T, Onuma H, Sumitani Y, Takahashi K, Tanaka T, Kondo T, Ishida H.
- Organizer
  American Diabetes Association 77rd scientific sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞での炎症性サイトカイン発現に対するAMPK活性化の影響とその生理的役割について2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、高橋和人、近藤琢磨、石田均
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞での炎症性サイトカイン発現に対するAMPK活性化の影響とメトフォルミンの効果について2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、五林可織、小沼裕寿、炭谷由計、高橋和人、田中利明、近藤琢磨、石田均
- Organizer
  第60回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞でのサイトカイン発現におけるAMPK活性化の影響とその生理的役割について2016
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、小沼裕寿、五林可織、高橋和人，炭谷由計，西田進，近藤琢磨，石田均
- Organizer
  第59回日本糖尿病学会学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 細胞骨格制御分子による糖取り込み機構の解析2014
- Author(s)
  興津理絵、阪上浩、保坂利男、高橋友奈、黒田雅士、Bayasgalan Jambaldorj、原田永勝、中屋豊
- Organizer
  第87回日本内分泌学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24500994
[Presentation] 細胞骨格制御分子による糖取り込み機構の解析2013
- Author(s)
  興津理絵、阪上浩、保坂利男、高橋友奈、黒田雅士、Bayasgalan Jambaldorj、原田永勝、中屋豊
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24500994
[Presentation] 加圧空気療法(Hyperbaric air therapy : HBAT)は糖尿病マウスの脂質異常症を改善する2010
- Author(s)
  山口美輪、保坂利男、勅使川原匡、寺田依里、福永恵子、西脇由佳、平田容子、酒井徹、中屋豊
- Organizer
  第14回日本統合医療学会
- Place of Presentation
  徳島大学
- Data Source
  KAKENHI-PROJECT-21500685
[Presentation] 加圧空気治療(Hyperbaric air therapy : HBAT)の糖脂質代謝への影響の検討2008
- Author(s)
  山口美輪、勅使川原匡、寺田依里、福永恵子、西脇由佳、Li Qinkai、平田容子、船木真理、中屋豊、保坂利男
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-21500685
[Presentation] 細胞骨格制御分子による糖取り込み機構の解析
- Author(s)
  興津理絵、黒田雅士、保坂利男、坂東正浩、原田永勝、中屋豊、阪上浩
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24500994
[Presentation] ATBP, Adipocyte-specific Tubulin-Binding Protein, Can Control Cytoskeletal Structure, and Insulin Stimulated Glucose Uptake
- Author(s)
  Masashi Kuroda, Rie Okitsu, Mari Kondo, Kasumi Nakagawa, Toshio Hosaka, Nagakatsu Harada, Hiroshi Skaue
- Organizer
  75th Scientific Sessions of American diabetes association
- Place of Presentation
  Boston, USA
- Year and Date
  2015-06-05 – 2015-06-09
- Data Source
  KAKENHI-PROJECT-24500994
[Presentation] 細胞骨格制御分子-synucleinによる糖取り込み機構の解析
- Author(s)
  黒田雅史、阪上浩、保坂利男、興津理絵、原田永勝、中屋豊
- Organizer
  日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-24500994

1. OBATA Toshiyuki (40325296)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KISHI Kazuhiro (70284320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. EBINA Yousuke (00112227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YUASA Tomoyuki (50304556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANGOKU Akira (10197593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKAYA Yutaka (50136222)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. SEIKE Junichi (30403744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAI Hiromichi (50403746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INUAKI Kouichi (20333007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAKAUE Hiroshi (60372645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 宇山攻 (90437658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 船木真理 (10467821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石田均 (80212893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
14. LI Qinkai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HOSAKA TOSHIO 保坂 利男

保坂 利男 ホサカ トシオ

HOSAKA Toshio 保坂 利男

Research Projects

Research Products

Co-Researchers

To clear the influences and search factors of fluctuational blood glucose by irregular meal patternPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The investigation on the pathological significance for lactate in insulin resistance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of the interaction between insulin sensitivity and fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Finding the novel anti-metabolic syndrome treatment by examining the mechanism of improvement for lipid metabolism with hyperbaric oxygen.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞支持基盤の弾性調節による初代培養脂肪・肝臓・骨格筋細胞の長期間機能保持の試み

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of nutrition on immune system and postoperative course of the patients with esophageal cancer and anticancer effect of supplements

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

APSノックアウトマウスは肥満によるインスリン抵抗性を回避できる

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of insulin signal transduction and diabetes mellitus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel mechanisms modulating palmitate-induced inflammatory factors in hypertrophied 3T3-L1 adipocytes by AMPK.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic Effects of Tofogliflozin are Efficiently Enhanced with Appropriate Dietary Carbohydrate Ratio and are Distinct from Carbohydrate Restriction.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CSP1 modulates insulin sensitivity by attenuating GLUT4 vesicle docking with the plasma membrane2013

Author(s)

Journal Title

Data Source

[Journal Article] Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes2013

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[Journal Article] Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.2012

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HOSAKA TOSHIO 保坂利男

保坂利男ホサカトシオ

HOSAKA Toshio 保坂利男

[Presentation] 肥大化脂肪細胞でのサイトカイン発現におけるAMPK活性化の影響とその生理的役割について2016