OHBA Motoi 大場基

Researcher Number	70297018
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2019: 昭和大学, 大学共同利用機関等の部局等, 講師 2010 – 2017: 昭和大学, 腫瘍分子生物学研究所, 講師 2006 – 2008: Showa University, Institute of Molecular Oncology, Assistant Professor, 腫瘍分子生物学研究所, 講師 2005: 昭和大学, 腫瘍分子生物学研究所, 助手 2003 – 2004: 昭和大学, 腫瘍分子医学研究所, 助手 2000 – 2002: 昭和大学, 腫瘍分子生物学研究所, 助手 1998 – 1999: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Tumor therapeutics / Functional biochemistry Except Principal Investigator Biological pharmacy / Biological Sciences / Experimental pathology
Keywords	Principal Investigator PKC / 分子標的薬 / 分子標的治療 / 炎症 / アポトーシス / 細胞内輸送 / 分子標的治療薬 / 肺がん / differentiation / signal transduction … More / hair growth / molecular targeting drug / development / 薬学 / 発生・分化 / 分化 / シグナル伝達 / 毛髪再生 / 発生 / 皮膚 / 炎症性疾患 / ゲノム創薬 / 再生医療 / 毛髪 / 再生 / CDK / ケラチノサイト / 細胞周期 / 老化 / 14-3-3 … More Except Principal Investigator Hic-5 / c-fos / 核移行 / focal adhesion / paxillin / 過酸化水素 / 接着斑 / パキシリン / 細胞接着斑 / 細胞周期 / シグナル伝達 / Smad3 / oxidative stress / c-foc / NES / Sp1 / FAK / nuclear lozalization / 酸化ストレス / Hic-5蛋白質 / 転写 / PTP-PEST / アポトーシス / Cキナーゼ / シグナル伝達移 / 幹細胞 / 形態形成 / 細胞増殖 / 細胞分化 / 上皮細胞 / p21 / ケラチノサイト / 14-3-3 / PKC / VEGF-E / トランスジェニックマウス / 系統発生 / VEGFR-1(Flt-1) / VEGFR-2(KDR) / VEGFR-1 (Flt-1) / VEGFR-2 (KDR) / 血管透過性 / がん転移 / VEGFR-1 / VEGFR-2 / 血管新生 / ノックインマウス / VEGF受容体 / VEGF / 腫瘍血管 / 活性酸素 / 細胞接着 / 化学発癌 / 癌治療 / ゲノム医学 / 構造生物学 / ウイルス発癌 / 海外派遣 / 国際学術 Less

Novel theraputic stratagey for lung cancer targeting PKCetaPrincipal Investigator
- Principal Investigator
  
  Ohba Motoi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Showa University
Novel therapeutic strategy for intractable inflammatory disease targeting PKCetaPrincipal Investigator
- Principal Investigator
  
  Ohba Motoi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Development of novel therapy for skin inflammatory diseases targeting PKCetaPrincipal Investigator
- Principal Investigator
  
  OHBA Motoi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Novel Molecular Targeted Therapy for Alopecia/Hairloss via PKCetaPrincipal Investigator
- Principal Investigator
  
  OHBA Motoi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Investigation of the mechanism of hair re-growth by PKCη and screening of its specific activatorsPrincipal Investigator
- Principal Investigator
  
  OHBA Motoi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
14-3-3σによる上皮細胞の最終分化、G2/M期調節機構の解明Principal Investigator
- Principal Investigator
  
  大場基
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Showa University
腫瘍の形成と維持の機構
- Principal Investigator
  
  渋谷正史
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
上皮組織構築・増殖・分化の制御機構とがん化Principal Investigator
- Principal Investigator
  
  大場基, 黒木登志夫
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
Regulation of adhesion signals by a focal adhesion protein, Hie5.
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESS
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
アメリカ大陸を中心としたがん研究先進グループとの研究交流
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo

[Book] 改訂培養細胞実験ハンドブック2009
- Author(s)
  大場基
- Total Pages
  329
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19590107
[Book] Surgery Frontier2005
- Author(s)
  大場基
- Total Pages
  111
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] Blockade of EGFR Activation Promotes TNF-Induced Lung Epithelial Cell Apoptosis and Pulmonary Injury.2019
- Author(s)
  Yamaoka T, Arata S, Homma M, Homma T, Kusumoto S, Ando K, Manabe R, Kishino Y, Ohba M, Tsurutani J, Takimoto M, Ohmori T, Sagara H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20(16) Issue: 16 Pages: 4021-4021
- DOI
  10.3390/ijms20164021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07226
[Journal Article] RAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR.2019
- Author(s)
  Nakatani K, Yamaoka T, Ohba M, Fujita KI, Arata S, Kusumoto S, Taki-Takemoto I, Kamei D, Iwai S, Tsurutani J, Ohmori T.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 18 Pages: 112-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07226
[Journal Article] New lung cancer treatment strategy with molecular target of PKCeta2019
- Author(s)
  Ohba, Motoi
- Journal Title
  
  Impact
  
  Volume: 2019(8) Issue: 8 Pages: 56-58
- DOI
  10.21820/23987073.2019.8.56
- Open Access
- Data Source
  KAKENHI-PROJECT-17K07226
[Journal Article] Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib.2019
- Author(s)
  Yamaoka T, Ohba M, Matsunaga Y, Tsurutani J, Ohmori T.
- Journal Title
  
  J Vis Exp.
  
  Volume: 26;(148). Issue: 148
- DOI
  10.3791/59473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07226
[Journal Article] Receptor Tyrosine Kinase-Targeted Cancer Therapy2018
- Author(s)
  Yamaoka Toshimitsu、Kusumoto Sojiro、Ando Koichi、Ohba Motoi、Ohmori Tohru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 11 Pages: 3491-3491
- DOI
  10.3390/ijms19113491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09590, KAKENHI-PROJECT-17K07226
[Journal Article] KRAS and EGFR Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in EGFR2018
- Author(s)
  Nakatani Kaori、Yamaoka Toshimitsu、Ohba Motoi、Fujita Ken-Ichi、Arata Satoru、Kusumoto Sojiro、Taki-Takemoto Iori、Kamei Daisuke、Iwai Shinichi、Tsurutani Junji、Ohmori Tohru
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 18 Issue: 1 Pages: 112-126
- DOI
  10.1158/1535-7163.mct-18-0591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08413, KAKENHI-PROJECT-16K09590, KAKENHI-PROJECT-17K07226
[Journal Article] Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure.2017
- Author(s)
  Yamaoka T, Ohba M, Arata S, Ohmori T.
- Journal Title
  
  J Vis Exp
  
  Volume: 126 Issue: 126 Pages: 1-10
- DOI
  10.3791/55967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09590, KAKENHI-PROJECT-17K07226
[Journal Article] Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation.2017
- Author(s)
  Yamaoka T, Ohmori T, Ohba M, Arata S, Murata Y, Kusumoto S, Ando K, Ishida H, Ohnishi T, Sasaki Y.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: - Issue: 7 Pages: 915-928
- DOI
  10.1158/1541-7786.mcr-16-0482
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05443, KAKENHI-PROJECT-25460153, KAKENHI-PROJECT-17K07226
[Journal Article] Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms.2017
- Author(s)
  Yamaoka T, Ohba M, Ohmori T.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 11 Pages: 2420-2442
- DOI
  10.3390/ijms18112420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09590, KAKENHI-PROJECT-17K07226
[Journal Article] Up-regulation of Syndecan-4 contributes to TGF-β1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells2016
- Author(s)
  市橋陽子、山岡利光、大森亨、大場基
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 5 Pages: 1-7
- DOI
  10.1016/j.bbrep.2015.11.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870736, KAKENHI-PROJECT-25460153
[Journal Article] The acquired resistant mechanisms for sequential treatment of EGFR-TKI to Met-TKI/EGFR-TKI in a Met amplified EGFR-TKI resistant lung adenocarcinoma cells, harboring EGFR activating mutation.2016
- Author(s)
  64.Yamaoka T., Ohmori T., Ohba M., Arata S., Kishino Y., Murata Y., Kusumoto S., Ishida H., Shirai T., Hirose T., Ohnishi T., and Sasaki Y.
- Journal Title
  
  Mol. Cancer Ther.
  
  Volume: 15 Issue: 12 Pages: 3040-3054
- DOI
  10.1158/1535-7163.mct-16-0313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153, KAKENHI-PROJECT-16K09590
[Journal Article] Improved method for long-term culture of epidermal stem cells by utilizing CD200R-expressing feeder cells.2015
- Author(s)
  Toya E., Ohba M.
- Journal Title
  
  The Showa University Journal of Medical Sciences.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153
[Journal Article] Protein Kinase C (PKC) η in Cigarette Smoke Extract-Induced Apoptosis in Human Lung Fibroblasts.2015
- Author(s)
  Son E., Kyung S., Lee S., Jeong S., Shin J., Ohba M., Yeo E., and Park J.
- Journal Title
  
  Human and Experimental Toxicology.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153
[Journal Article] Role of Protein Kinase C (PKC) η in Cigarette Smoke Extract-Induced Apoptosis in Human Lung Fibroblasts.2015
- Author(s)
  Son E., Kyung S., Lee S., Jeong S., Shin J., Ohba M., Yeo E., and Park J
- Journal Title
  
  Human and Experimental Toxicology
  
  Volume: 34 Issue: 9 Pages: 869-877
- DOI
  10.1177/0960327114561343
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460153
[Journal Article] Improved long-term culture of epidermal stem cells utilizing CD200R-expressing feeder cells.2015
- Author(s)
  Toya E, Ohba M
- Journal Title
  
  The Showa University Journal of Medical Sciences.
  
  Volume: 27 Pages: 83-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153
[Journal Article] Silver Nanoscale Hexagonal Column Chips for Detecting Cell-Free DNA and Circulating Nucleosomes in Cancer Patients2015
- Author(s)
  H. Ito, K. Hasegawa, Y. Hasegawa, T. Nishimaki, K. Hosomichi, S. Kimura, M. Ooba, H. Yao, M. Onimaru, I. Inoue, H. Inoue
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 10455-10455
- DOI
  10.1038/srep10455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K04593, KAKENHI-PROJECT-25460153, KAKENHI-PROJECT-26460688
[Journal Article] Phosphorylation of ZO-1 at Thr770/772 disrupts endothelial tight junction assembly and barrier function.2014
- Author(s)
  Rima Chattopadhyay, Elena Dyukova, Nikhlesh K. Singh, Motoi Ohba, and Gadinarthi N Rao.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289(6) Issue: 6 Pages: 3148-63
- DOI
  10.1074/jbc.m113.528190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460153
[Journal Article] Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes2010
- Author(s)
  Kamioka N., Ohba M.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 394 Pages: 106-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] Protein kinase C δ and η differently regulate the expression of loricrin and Jun family proteins in human keratinocytes Biochem2010
- Author(s)
  Kamioka N, Akahane T, Kohno Y, Kuroki T, Iijima M, Honma Iand Ohba M
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 394 Issue: 1 Pages: 106-111
- DOI
  10.1016/j.bbrc.2010.02.125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor.2010
- Author(s)
  Ikuta T, Ohba M., Zouboulis C., Fujii-Kuriyama Y., Kawajiri K
- Journal Title
  
  J. Derm. Sci
  
  Volume: 58(3) Issue: 3 Pages: 211-6
- DOI
  10.1016/j.jdermsci.2010.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] ヒト三次元培養皮膚への遺伝子導入法の確立と表皮分化へのCキナーゼの関与2010
- Author(s)
  上岡なぎさ、本間生夫、赤羽智子、河野葉子、飯島正文、大場基
- Journal Title
  
  昭和医学会雑誌2010
  
  Volume: Vol. 70 (3) Pages: 253-262
- NAID
  130000852909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor.2010
- Author(s)
  Ikuta T., Ohba M.
- Journal Title
  
  J.Derm.Sci.
  
  Volume: 58 Pages: 211-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] Activation of PAR-2 stimulates sVEGFR-1 release via EGF receptortransactivation in endothelial cells2010
- Author(s)
  Bahjat Al-Ani, Ohba M.
- Journal Title
  
  Hypertention
  
  Volume: 55 Pages: 689-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] Activation of PAR-2 stimulates sVEGFR-1 release via EGF receptortransactivation in endothelial cells2010
- Author(s)
  Bahjat Al-Ani, Peter W. Hewett, Melissa J. Cudmore, Takeshi Fujisawa, Mahmoud, Saifeddine, Hannah Williams, Wenda Ramma, Samir Sissaoui, Padma-Sheela, Jayaraman, Motoi Ohba, Shakil Ahmad, Morley D.Hollenberg and Asif Ahmed.
- Journal Title
  
  Hypertention
  
  Volume: 55(3) Issue: 3 Pages: 689-97
- DOI
  10.1161/hypertensionaha.109.136333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590105
[Journal Article] Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis2009
- Author(s)
  Watanabe H, , Ohba M, Hizawa N, Adachi M, Huang SK, Iijima M. (他6名)
- Journal Title
  
  J. Invest. Dermatol. 129(3)
  
  Pages: 650-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590107
[Journal Article] Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis2008
- Author(s)
  Park JW, Kim HP, Lee SJ, Wang X, Wang Y, Ifedigbo E, Watkins SC, Ohba M, Ryter S.W., Vyas Y.M., Choi A.M.
- Journal Title
  
  J. Immunol. 180(7)
  
  Pages: 4668-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590107
[Journal Article] Activation of protein kinaseCζ mediates luteinizing hormone-or forskolin-induced NGFI-B expression in preovulatory granulosa cells of rat ovary2007
- Author(s)
  Park J.I., Kim S.G., Chun J.S., Seo Y.M., Jeon M.J., Ohba M., Kim H.J., Chun S.Y.
- Journal Title
  
  Mol. Cell Endocrinol. 270(1-2)
  
  Pages: 79-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590107
[Journal Article] A protein kinase Cε-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2.2007
- Author(s)
  Steinberg R, Harari OA, Lidington EA, Boyle JJ, Nohadani M, Samarel AM, Ohba M, Haskard DO, Mason JC.
- Journal Title
  
  J. J. Biol. Chem. 282(44)
  
  Pages: 32288-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590107
[Journal Article] Induction of Hair Re-growth by Protein Kinase C2006
- Author(s)
  Ohba M.
- Journal Title
  
  New Frontiers in Regenerative Medicine 1
  
  Pages: 29-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] Induction of Hair Re-growth by Protein Kinase C η2006
- Author(s)
  Ohba M.
- Journal Title
  
  New Frontiers in Regenerative Medicine 1
  
  Pages: 29-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] Pituitary adenylate cyclase-activating polypeptide-induced differentiation of embryonic neural stem cells into astrocytes is mediated via the beta isoform of protein kinase C.2006
- Author(s)
  Watanabe J., Ohba M., Ohno F., Kikuyama S., Nakamura M., Nakaya K., Arimura A., Shioda S., Nakajo S.
- Journal Title
  
  J. Neurosci Res. 84(8)
  
  Pages: 1645-1655
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells.2005
- Author(s)
  Lidington E.A., Steinberg R, Kinderlerer A.R., Landis R.C., Ohba M., Samarel A., Haskard D.O., Mason J.C.
- Journal Title
  
  Am. J. Physiol. Cell Physiol. 289(6)
  
  Pages: 1437-1447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] Protocol of the dominant negative mutant construction.2005
- Author(s)
  Ohba M.
- Journal Title
  
  Surgery Frontier 12
  
  Pages: 175-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Journal Article] Protein kinase Cα is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells.2005
- Author(s)
  Yutsudo Y.Kido Y., Okabayashi Y., Matsumoto M., Ogawa W., Ohba M., Kuroki T., Kasuga M.
- Journal Title
  
  Pancreas. 30(1)
  
  Pages: 50-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590095
[Patent] ベクター、形質転換体、PKCη発現調節物質のスクリーニング方法並びにPKCη発現阻害剤2019
- Inventor(s)
  大場　基
- Industrial Property Rights Holder
  昭和大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-181792
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K07226
[Patent] ヒトＰＫＣη遺伝子発現阻害siＲＮＡ及びそれを含む医薬品2015
- Inventor(s)
  大場　基
- Industrial Property Rights Holder
  大場　基
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-206380
- Filing Date
  2015-10-20
- Data Source
  KAKENHI-PROJECT-25460153
[Patent] PKCη発現抑制系2012
- Inventor(s)
  大場基
- Industrial Property Rights Holder
  大場基
- Industrial Property Number
  2012-246772
- Filing Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-22590105
[Patent] 特許権2012
- Inventor(s)
  大場　基
- Industrial Property Rights Holder
  大場　基
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-22590105
[Patent] 毛髪再生方法2008
- Inventor(s)
  大場基、黒木登志夫
- Industrial Property Rights Holder
  昭和大学、(株)バイオマスター
- Industrial Property Number
  2004-264736
- Filing Date
  2008
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] Regulation of accelerated membrane trafficking by PKC eta via the phosphorylation of Rab11 in lung cancer cells. 和文演題名:PKCηによる肺がん特異的な増殖因子受容体膜輸送の亢進機構2019
- Author(s)
  大場基、山岡利光、石川文博、戸谷衣都子、村上善則
- Organizer
  第７８回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] 術前化学療法有り、無し乳がん患者における予後因子としてのBRCAness検討2019
- Author(s)
  松永有紀、大場基、中村清吾、鶴谷純司
- Organizer
  第７８回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] Involvement of a cell adhesion molecule, CADM1, in cancer invasion and metastasis2018
- Author(s)
  村上善則、舩木桐子、坪井裕見、松原大祐、大場基、伊東剛
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] EGFRT790M発現肺腺癌才簿株を用いた第3世代EGFR-TKI耐性細胞の樹立とその機序の検討2018
- Author(s)
  中谷香織、山岡利光、大場基、大森亨、大場基、藤田健一、滝伊織、亀井大輔、岩井信一、佐々木康綱
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] Mechanism of resistance to third-generation EGFR-TKI, rociletinib, in lung adenocarcinoma cells with EGFR-T790M mutation2018
- Author(s)
  YAMAOKA Toshimitsu NAKATANI Kaori OHBA Motoi FUJITA Ken-ichi ARATA Satoru IWAI Shinichi OHMORI Tohru
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] Screening of metastasis-related genes by microarray analysis of lung cancer cells usisng experimetal lung metastasis2018
- Author(s)
  熊谷友紀、伊東剛、永田政義、河合剛人、松原大祐、大場基、村上善則
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] Resistance mechanisms to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in lung adenocarcinoma cells harboring the EGFR-T790M mutation2018
- Author(s)
  NAKATANI Kaori YAMAOKA Toshimitsu OHMORI Tohru OHBA Motoi FUJITA Ken-ichi TAKI Iori KAMEI Daisuke IWAI Shinichi SASAKI Yasutsuna
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] 10-methyl-aplog-1 enhances the cytotoxic effects of HDAC inhibitor in esophageal squamous carcinoma cells2018
- Author(s)
  OHBA Motoi TOYA Etsuko ARATA Satoru YAMAOKA Toshimitsu IRIE Kazuhiro SASAKI Yasutsuna
- Organizer
  第16回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] EGFR-mutationを伴う肺腺癌細胞株におけるEGFR-TKIとMET-TKIへの獲得耐性機序2017
- Author(s)
  山岡利光、大森亨、大場基、村田泰則、大木康成、楠本壮二郎、大西司、相良博典
- Organizer
  第57回　日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] 10-methyl-aplog-1 augments the therapeutic efficacy of HDAC inhibitor in esophageal squamous carcinoma cells2017
- Author(s)
  Motoi Ohba, Etsuko Toya, Satoru Arata, Toshimitsu Yamaoka Kazuhiro Irie and Yasutsuna Sasaki
- Organizer
  第76回　日本癌学会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] 肺腺癌細胞PC-9におけるアファチニブ獲得耐性機序2017
- Author(s)
  山岡利光、大場基、荒田悟、大森亨
- Organizer
  第76回　日本癌学会
- Data Source
  KAKENHI-PROJECT-17K07226
[Presentation] Inhibition of metastasis of lung adenocarcinoma cells via the perturbed localization of Rab11FIP1/RCP by PKCh depletion2015
- Author(s)
  Ohba M., Toya E., Yamaoka T., and Sasaki Y.
- Organizer
  日本臨床腫瘍学会
- Place of Presentation
  札幌市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25460153
[Presentation] 非小細胞肺癌細胞におけるPKCηによる細胞遊走・浸潤制御機構の解析2014
- Author(s)
  外谷衣都子、山岡利光、大森亨、佐々木康綱、大場　基、
- Organizer
  日本薬学会
- Place of Presentation
  熊本県熊本市
- Data Source
  KAKENHI-PROJECT-25460153
[Presentation] 非小細胞肺がんに対する新たな治療法としてのprotein kinase Cη2014
- Author(s)
  大場　基、外谷衣都子、山岡利光、大森亨、佐々木康綱
- Organizer
  日本薬学会
- Place of Presentation
  熊本県熊本市
- Data Source
  KAKENHI-PROJECT-25460153
[Presentation] Differential role of protein kinase C ηin cell growth between squamous cell carcinoma and adenocarcinoma2013
- Author(s)
  Motoi Ohba, Tohru Ohmori, Toshio Kurokiand Etsuko Toya
- Organizer
  19thInternational Charles Heidelberger Symposium In Cancer research
- Place of Presentation
  Kagoshima, Japan
- Data Source
  KAKENHI-PROJECT-22590105
[Presentation] Differential role of protein kinase C eta in cell growth between squamous cell carcinoma and adenocarcinoma.2013
- Author(s)
  大場　基
- Organizer
  19th International Charles Heidelberger Symposium On Cancer Research
- Place of Presentation
  鹿児島県鹿児島市
- Data Source
  KAKENHI-PROJECT-22590105
[Presentation] 毛包上皮幹細胞の永代培養法と分化誘導法の確立2011
- Author(s)
  大場基
- Organizer
  昭和大学共同研究研究成果発表会
- Place of Presentation
  東京
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22590105
[Presentation] 毛包上皮幹細胞の永代培養法と分化誘導法の確立2009
- Author(s)
  大場基
- Organizer
  昭和大学共同研究成果発表会
- Place of Presentation
  東京都
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] Involvement of PKCeta in growth and differentiation of epithelial cells and innate immune response2008
- Author(s)
  大場基
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] PKCηを標的分子とした毛髪再生法の開発2008
- Author(s)
  大場基
- Organizer
  昭和大学共同研究発表会
- Place of Presentation
  東京
- Year and Date
  2008-03-01
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] PKCηを標的分子とした毛髪再生法の開発2008
- Author(s)
  大場基
- Organizer
  昭和大学共同研究研究成果発表会
- Place of Presentation
  東京
- Year and Date
  2008-03-01
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] Involvement of PKCeta in growth and differentiation of epithelial cells and innate immune response2008
- Author(s)
  大場基
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590107
[Presentation] PKCeta controls the proliferation of lung adenocarcinoma cells via EGFR and MET endocytic trafficking.
- Author(s)
  Motoi Ohba, Etsuko Toya, Toshimitsu Yamaoka, Tohru Ohmori, and Yasutsuna Sasaki
- Organizer
  日本癌学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460153
[Presentation] PKCeta controls the proliferation of lung adenocarcinoma cells via EGFR and MET endocytic trafficking.
- Author(s)
  Motoi Ohba, Etsuko Toya, Toshimitsu Yamaoka, Tohru Ohmori, Toshio Kuroki and Yasutsuna Sasaki.
- Organizer
  日本臨床腫瘍学会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-07-17 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25460153
[Presentation] PKCeta inhibits the cell proliferation and motility of lung adenocarcinoma cells via regulation of endocytic trafficking.
- Author(s)
  Etsuko Toya, Toshimitsu Yamaoka, Yasutsuna Sasaki and Motoi Ohba.
- Organizer
  日本分子生物学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460153

1. Shibanuma Motoko (60245876)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MASHIMO Junn'ichi (60054045)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NISHIYA Naoyuki (10286867)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NOSE Kiyoshi (70012747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. EGAWA Kiyoshi (00095879)

# of Collaborated Projects: 2 results

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6. 後藤典子 (10251448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 黒木登志夫 (90006073)

# of Collaborated Projects: 2 results

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8. Kohno Yohko (40195681)

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9. 山本雅 (40134621)

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10. 岡田明子 (00233320)

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11. 荒木令江 (80253722)

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12. 黒田昌宏 (50225306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 清野透 (10186356)

# of Collaborated Projects: 1 results

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14. 本間美和子 (40192538)

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15. 細川好孝 (60229193)

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16. 白澤専二 (10253535)

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17. 菊池章 (10204827)

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18. 生田和良 (60127181)

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19. 浜口道成 (90135351)

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20. 神田浩明 (90260067)

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21. 上出利光 (00160185)

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22. 秋山伸一 (60117413)

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23. 渋谷正史 (10107427)

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24. 矢花直幸 (90292846)

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25. 櫻井佳子 (10361619)

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26. 中村佐千枝 (60313087)

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27. 丸義朗 (00251447)

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28. 柏木麻里子 (80296962)

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29. 千田和広 (00192188)

# of Collaborated Projects: 1 results

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30. YAMAOKA Toshimitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
31. OHMORI Tohru

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# of Collaborated Products: 3 results
32. KAMEI Daisuke

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33. 楠本壮二郎

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34. 荒田悟

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35. 八尾浩史

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OHBA Motoi 大場 基

Research Projects

Research Products

Co-Researchers

Novel theraputic stratagey for lung cancer targeting PKCetaPrincipal Investigator

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Novel therapeutic strategy for intractable inflammatory disease targeting PKCetaPrincipal Investigator

Principal Investigator

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Development of novel therapy for skin inflammatory diseases targeting PKCetaPrincipal Investigator

Principal Investigator

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Novel Molecular Targeted Therapy for Alopecia/Hairloss via PKCetaPrincipal Investigator

Principal Investigator

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Investigation of the mechanism of hair re-growth by PKCη and screening of its specific activatorsPrincipal Investigator

Principal Investigator

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14-3-3σによる上皮細胞の最終分化、G2/M期調節機構の解明Principal Investigator

Principal Investigator

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Research Institution

腫瘍の形成と維持の機構

Principal Investigator

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Review Section

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上皮組織構築・増殖・分化の制御機構とがん化Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割

Principal Investigator

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Regulation of adhesion signals by a focal adhesion protein, Hie5.

Principal Investigator

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ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESS

Principal Investigator

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アメリカ大陸を中心としたがん研究先進グループとの研究交流

Principal Investigator

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Research Institution

[Book] 改訂 培養細胞実験ハンドブック2009

Author(s)

Total Pages

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Data Source

OHBA Motoi 大場基

[Book] 改訂培養細胞実験ハンドブック2009