ISHIKAWA Minoru 石川稔

Researcher Number	70526839
Other IDs
Affiliation (Current)	2025: 東北大学, 生命科学研究科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 東北大学, 生命科学研究科, 教授 2018: 東京大学, 定量生命科学研究所, 准教授 2013 – 2017: 東京大学, 分子細胞生物学研究所, 准教授 2012: 東京大学, 分子細胞生物学研究所, 講師 2009 – 2011: The University of Tokyo, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Pharmaceutical Sciences and related fields Except Principal Investigator Drug development chemistry / Complex systems / Living organism molecular science
Keywords	Principal Investigator 創薬化学 / タンパク質ノックダウン / 翻訳後修飾 / 神経変性疾患 / 近接制御 / タンパク質のタグ化 / 疾患関連タンパク質 / タグ化 / ハイブリッド分子 / タンパク質タグ化 … More / アミロイド / アミロイドβ / 多重薬理作用 / 標的分子同定 / 標的タンパク質 / タンパク質分解 / 医薬分子設計 / 転写抑制 / 構造展開 / ペプチド等価体 / ビタミンD受容体 / 拮抗物質 / 非ステロイドリガンド / 核内受受容体 / コアクチベーター阻害 / リガンド / 核内受容体 … More Except Principal Investigator 生理活性物質 / 核内受容体リガンド / マルチテンプレート / プロテインノックダウン / タンパク質分解 / サリドマイド / プロテアソーム / ユビキチン / ペプチド / IAP / 脱ユビキチン化酵素 / 血管新生 / セレブロン / デコイ核酸 / ステープルペプチド / セレブロンモジュレーター / SNIPER / ケミカルプロテインノックダウン / 固相合成 / アプタマーPROTAC / 神経変性疾患 / がん / 催奇性 / CRBN / PROTAC / 薬理シャペロン / 分子設計 / 核内受容体 / ケイ素 / ブロモドメイン / ハンチンチン / 阻害剤 / 構造展開 / 多重薬理 / 変異ロドプシン / 網膜色素変性症 / 酵素阻害剤 / ニーマン・ピック病Ｃ型 / 膜タンパク質 / 蛋白質相互作用 / 蛋白変性症 / フォールディング異常症 / トラフィッキング / CRABPD / レチノイン酸 / CRABP / ハイブリッド分子 / 結合タンパク / cIAP1 / タンパク質分解誘導 / ベスタチン / タンパク質の自己分解 / 生物活性分子の設計・合成 Less

変性タンパク質に対応する創薬モダリティPrincipal Investigator
- Principal Investigator
  
  石川稔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tohoku University
ミトコンドリア局在標的タンパク質分解薬の活性向上Principal Investigator
- Principal Investigator
  
  石川稔
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
medicinal chemisty based on proximity control of disease related proteinsPrincipal Investigator
- Principal Investigator
  
  石川稔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Chemical protein knockdown technology and cell regulation
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
  National Institute of Health Sciences
A novel drug discovery modality inducing tagging of disease related proteinsPrincipal Investigator
- Principal Investigator
  
  Ishikawa Minoru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
  The University of Tokyo
chemical biology for cytosolic amyloid betaPrincipal Investigator
- Principal Investigator
  
  Ishikawa Minoru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  The University of Tokyo
Polypharmacology based on dynamism of the target protein
- Principal Investigator
  
  Hashimoto Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Reverse proteomics of post-translational modifications utilizing small moleculesPrincipal Investigator
- Principal Investigator
  
  Ishikawa Minoru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Polypharmacological approach to hepatitis CPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Minoru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Novel strategy for medicinal chemistry utilizing protein knockdownPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Minoru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Chemical control of protein dramatype
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target Proteins
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Discovery of inhibitors for nuclear receptor functions with multiple mechanismsPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Minoru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

[Book] The Practice of Medicinal Chemistry, 4th edition2015
- Author(s)
  Minoru Ishikawa, Yuichi Hashimoto（分担執筆）
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-25293027
[Journal Article] Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties2022
- Author(s)
  Hirai Keigo、Yamashita Hiroko、Tomoshige Shusuke、Mishima Yugo、Niwa Tatsuya、Ohgane Kenji、Ishii Mayumi、Kanamitsu Kayoko、Ikemi Yui、Nakagawa Shinsaku、Taguchi Hideki、Sato Shinichi、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 3 Pages: 396-402
- DOI
  10.1021/acsmedchemlett.1c00500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-PLANNED-20H05925
[Journal Article] Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader2022
- Author(s)
  Nakano Naoko、Fukuda Kazuo、Tashiro Etsu、Ishikawa Haruka、Nagano Waka、Kawamoto Rie、Mori Alice、Watanabe Misao、Yamazaki Ryu、Nakane Takahisa、Naito Mikihiko、Okamoto Iwao、Itoh Susumu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 6 Pages: 631-640
- DOI
  10.1093/jb/mvac021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06975, KAKENHI-PROJECT-20K05732, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H03456
[Journal Article] BODIPY Catalyzes Proximity‐Dependent Histidine Labelling2022
- Author(s)
  Nakane Keita、Niwa Tatsuya、Tsushima Michihiko、Tomoshige Shusuke、Taguchi Hideki、Nakamura Hiroyuki、Ishikawa Minoru、Sato Shinichi
- Journal Title
  
  ChemCatChem
  
  Volume: - Issue: 9
- DOI
  10.1002/cctc.202200077
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04699, KAKENHI-PROJECT-18H02551, KAKENHI-PLANNED-20H05925, KAKENHI-PUBLICLY-21H05503, KAKENHI-PROJECT-19H02848
[Journal Article] Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling2022
- Author(s)
  Nakane Keita、Nagasawa Haruto、Fujimura Chizu、Koyanagi Eri、Tomoshige Shusuke、Ishikawa Minoru、Sato Shinichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11622-11622
- DOI
  10.3390/ijms231911622
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05503, KAKENHI-PROJECT-19H02848, KAKENHI-PLANNED-18H05502
[Journal Article] 標的タンパク質分解薬による創薬パラダイムシフト -低分子リガンドの活躍2022
- Author(s)
  友重秀介, 石川稔
- Journal Title
  
  月刊細胞
  
  Volume: 54 Pages: 504-507
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] 分子間相互作用低下による生物活性物質の水溶性向上策2022
- Author(s)
  石川稔
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 142 Pages: 365-379
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] 水溶性・脂溶性のアウフヘーベン2021
- Author(s)
  石川稔
- Journal Title
  
  Farumashia
  
  Volume: 57 Issue: 7 Pages: 620-624
- DOI
  10.14894/faruawpsj.57.7_620
- NAID
  130008060280
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02551
[Journal Article] Functionalization of Human Serum Albumin by Tyrosine Click2021
- Author(s)
  Obara Satsuki、Nakane Keita、Fujimura Chizu、Tomoshige Shusuke、Ishikawa Minoru、Sato Shinichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8676-8676
- DOI
  10.3390/ijms22168676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-19H02848
[Journal Article] PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders2021
- Author(s)
  Shusuke Tomoshige, Minoru Ishikawa
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 7 Pages: 3346-3354
- DOI
  10.1002/anie.202004746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery2021
- Author(s)
  Ichikawa Yuki、Hiramatsu Michiaki、Mita Yusuke、Makishima Makoto、Matsumoto Yotaro、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 2 Pages: 446-456
- DOI
  10.1039/d0ob02083d
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17H06173
[Journal Article] In vivo synthetic chemistry of proteolysis targeting chimeras (PROTACs)2021
- Author(s)
  Tomoshige Shusuke、Ishikawa Minoru
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 41 Pages: 116221-116221
- DOI
  10.1016/j.bmc.2021.116221
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] 医薬リード化合物の体内動態改善法 -水溶性・脂溶性のアウフヘーベン-2021
- Author(s)
  石川稔
- Journal Title
  
  ファルマシア
  
  Volume: 57 Pages: 620-624
- NAID
  130008060280
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Proximity Histidine Labeling by Umpolung Strategy Using Singlet Oxygen2021
- Author(s)
  Nakane Keita、Sato Shinichi、Niwa Tatsuya、Tsushima Michihiko、Tomoshige Shusuke、Taguchi Hideki、Ishikawa Minoru、Nakamura Hiroyuki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 20 Pages: 7726-7731
- DOI
  10.1021/jacs.1c01626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03984, KAKENHI-PLANNED-18H05502, KAKENHI-PUBLICLY-20H04699, KAKENHI-PUBLICLY-21H05503, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-19H02848, KAKENHI-PLANNED-20H05925
[Journal Article] Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog2021
- Author(s)
  Morimoto Junki、Miyamoto Kazunori、Ichikawa Yuki、Uchiyama Masanobu、Makishima Makoto、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 12697-12697
- DOI
  10.1038/s41598-021-92028-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-20H02720
[Journal Article] 疾患原因タンパク質の寿命を短縮する分子の創製と医薬応用への課題2020
- Author(s)
  石川稔
- Journal Title
  
  Drug Delivery System
  
  Volume: 35 Pages: 229-239
- NAID
  130007930433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02551
[Journal Article] 標的タンパク質分解薬の動向ーPROTACsの先を見据えて2020
- Author(s)
  友重秀介、石川稔
- Journal Title
  
  月刊化学
  
  Volume: 75 Pages: 70-71
- Data Source
  KAKENHI-PROJECT-18H02551
[Journal Article] Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs2020
- Author(s)
  Shioi Ryuta、Karaki Fumika、Yoshioka Hiromasa、Noguchi-Yachide Tomomi、Ishikawa Minoru、Dodo Kosuke、Hashimoto Yuichi、Sodeoka Mikiko、Ohgane Kenji
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: e0243746-e0243746
- DOI
  10.1371/journal.pone.0243746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15949, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 4 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-ORGANIZER-18H05497
[Journal Article] 神経変性疾患治療に向けたタンパク質分解アプローチ2020
- Author(s)
  友重秀介、石川稔
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2326-2330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02551
[Journal Article] 生細胞内の疾患関連タンパク質を減少させる低分子創薬手法の開発2020
- Author(s)
  石川稔、橋本祐一
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 78 Pages: 402-413
- NAID
  130007841753
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] 神経変性疾患治療に向けたタンパク質分解アプローチ2020
- Author(s)
  友重秀介、石川稔
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2326-2330
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] 生細胞内の疾患関連タンパク質を減少させる低分子創薬手法の開発2020
- Author(s)
  石川稔、橋本祐一
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 78 Pages: 402-413
- NAID
  130007841753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02551
[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020
- Author(s)
  Yamashita Hiroko、Tomoshige Shusuke、Nomura Sayaka、Ohgane Kenji、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 1 Pages: 115175-115175
- DOI
  10.1016/j.bmc.2019.115175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17K15487
[Journal Article] 疾患疾患原因タンパク質の寿命を短縮する分子の創製と医薬応用への課題2020
- Author(s)
  石川稔
- Journal Title
  
  Drug Delivery System
  
  Volume: 35 Pages: 229-239
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton2018
- Author(s)
  Nishiyama Yuko、Fujii Shinya、Makishima Makoto、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 7 Pages: 2090-2090
- DOI
  10.3390/ijms19072090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-18H02551
[Journal Article] Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton2018
- Author(s)
  Nishiyama Yuko、Mori Shuichi、Makishima Makoto、Fujii Shinya、Kagechika Hiroyuki、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 9 Issue: 7 Pages: 641-645
- DOI
  10.1021/acsmedchemlett.8b00058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-18H02551
[Journal Article] Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole2018
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 28 Issue: 4 Pages: 707-710
- DOI
  10.1016/j.bmcl.2018.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Structural Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists with Improved Aqueous Solubility2018
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 4 Pages: 796-801
- DOI
  10.1016/j.bmcl.2017.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997
[Journal Article] Photo-enhanced aqueous solubilization of an azo-compound2017
- Author(s)
  Minoru Ishikawa, Takuya Ohzono, Takao Yamaguchi, Yasuo Norikane
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6909-6909
- DOI
  10.1038/s41598-017-06947-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-16K17930
[Journal Article] 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators2017
- Author(s)
  Kaori Endo-Umeda, Atsushi Aoyama, Masato Shimizu, Minoru Ishikawa, Yuichi Hashimoto, Sachiko Yamada, Makoto Makishima
- Journal Title
  
  Journal of Steroid Biochemistry & Molecular Biology
  
  Volume: 172 Pages: 136-148
- DOI
  10.1016/j.jsbmb.2017.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027
[Journal Article] Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP302017
- Author(s)
  Sato Yusuke、Okatsu Kei、Saeki Yasushi、Yamano Koji、Matsuda Noriyuki、Kaiho Ai、Yamagata Atsushi、Goto-Ito Sakurako、Ishikawa Minoru、Hashimoto Yuichi、Tanaka Keiji、Fukai Shuya
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 24 Issue: 11 Pages: 911-919
- DOI
  10.1038/nsmb.3469
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15072, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-15J10559, KAKENHI-PROJECT-16K18545, KAKENHI-PROJECT-26000014
[Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017
- Author(s)
  Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 12 Pages: 2781-2787
- DOI
  10.1016/j.bmcl.2017.04.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
[Journal Article] Specific fluorescence labeling of target protein by using ligand-4-azidophthalimide conjugate2017
- Author(s)
  Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko Sodeoka, Takao Yamaguchi
- Journal Title
  
  Chemical Communications
  
  Volume: 53 Issue: 62 Pages: 8751-8754
- DOI
  10.1039/c7cc03252h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-16K17930
[Journal Article] Discovery of Small Molecules that Induce the Degradation of Huntingtin2017
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, and Minoru Ishikawa
- Journal Title
  
  Angew. Chem. Int. Ed. Engl.
  
  Volume: 56 Issue: 38 Pages: 11530-11533
- DOI
  10.1002/anie.201706529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027
[Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017
- Author(s)
  Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 14 Pages: 3131-3134
- DOI
  10.1016/j.bmcl.2017.05.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol pharmacol
  
  Volume: 91 Issue: 3 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression2017
- Author(s)
  Yosuke Toyota, Sayaka Nomura, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 12 Pages: 2776-2780
- DOI
  10.1016/j.bmcl.2017.04.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Structural Development Studies of Pyrazoloketone-Derived Acetyl-CoA Carboxylase Inhibitors2017
- Author(s)
  Shogo Okazaki, Taki Sakai, Minoru Ishikawa, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Heterocycles
  
  Volume: 95 Issue: 1 Pages: 595-607
- DOI
  10.3987/com-16-s(s)30
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K17930, KAKENHI-PROJECT-25293027
[Journal Article] Development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists2016
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ChemMedChem
  
  Volume: 11 Issue: 20 Pages: 2347-2360
- DOI
  10.1002/cmdc.201600305
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptorα/δ (PPARα/δ) dual agonists2016
- Author(s)
  Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 21 Pages: 5455-5461
- DOI
  10.1016/j.bmc.2016.08.067
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand2016
- Author(s)
  Shusuke Tomoshige, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 14 Pages: 3144-3148
- DOI
  10.1016/j.bmc.2016.05.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-16K15137
[Journal Article] Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure2016
- Author(s)
  Michiaki Hiramatsu, Yuki Ichikawa, Shusuke Tomoshige, Makoto Makishima, Atsuya Muranaka, Masanobu Uchiyama, Takao Yamaguchi, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Chem. Asian J.
  
  Volume: 11 Issue: 15 Pages: 2210-2217
- DOI
  10.1002/asia.201600744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229001, KAKENHI-PROJECT-25293027
[Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activit2016
- Author(s)
  Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 21 Pages: 5258-5269
- DOI
  10.1016/j.bmc.2016.08.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
[Journal Article] Structure-Activity Relationships of Benzhydrol Derivatives Based on 1'-Acetoxychavicol Acetate (ACA) and their Inhibitory Activities on Multiple Myeloma Cell Growth via Inactivation of the NF-kB Pathway2015
- Author(s)
  Takashi Misawa, Kosuke Dodo, Minoru Ishikawa, Yuichi Hashimoto, Morihiko Sagawa, Masahiro Kizaki, Hiroshi Aoyama
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 9 Pages: 2241-2246
- DOI
  10.1016/j.bmc.2015.02.039
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670053, KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-15K09490, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-25293027
[Journal Article] Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists2015
- Author(s)
  Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto and Shinya Fujii
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letter
  
  Volume: 25 Issue: 16 Pages: 3350-3354
- DOI
  10.1016/j.bmcl.2015.05.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J12421, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.2015
- Author(s)
  Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 23 Issue: 2 Pages: 328-339
- DOI
  10.1016/j.bmc.2014.11.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-24590136, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Styrylphenylphthalimides as novel transrepression-selective liver X receptor (LXR) modulators2015
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Atsushi Aoyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 6 Issue: 8 Pages: 902-907
- DOI
  10.1021/acsmedchemlett.5b00170
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules2015
- Author(s)
  Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 13 Issue: 38 Pages: 9746-9750
- DOI
  10.1039/c5ob01395j
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin- 6(5H)-one skeleton from a liver X receptor ligand2014
- Author(s)
  Y.Nishiyama, M.Nakamura, T.Misawa, M.Nakagomi, M.Makishima, M.Ishikawa, Y.Hashimoto
- Journal Title
  
  Boorg. Med. Chem.
  
  Volume: 22 Issue: 9 Pages: 2799-2808
- DOI
  10.1016/j.bmc.2014.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670053
[Journal Article] 7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity.2014
- Author(s)
  Endo-Umeda K, Yasuda K, Sugita K, Honda A et al.
- Journal Title
  
  J. Steroid Biochem. Mol. Biol.
  
  Volume: 140 Pages: 7-16
- DOI
  10.1016/j.jsbmb.2013.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590051, KAKENHI-PROJECT-24590136, KAKENHI-PROJECT-25670053
[Journal Article] Structureactivity relationships of bisphenol A analogs at estrogen receptors (ERs) : discovery of an ERα-selective antagonist2013
- Author(s)
  K. Maruyama, M. Nakamura, S. Tomoshige, K.Sugita, M.Makishima, Yuichi Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 14 Pages: 4031-4036
- DOI
  10.1016/j.bmcl.2013.05.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24590136, KAKENHI-PROJECT-25670053
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012
- Author(s)
  Yukihiro Itoh, Minoru Ishikawa, Risa Kitaguchi, Keiichiro Okuhira, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Pages: 4453-4457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790125
[Journal Article] Double Protein Knockdown of cIAP1 and CRABP-II Using a Hybrid Molecule Consisting of ATRA and IAPs Antagonist2012
- Author(s)
  Yukihiro Itoh, Minoru Ishikawa, Risa Kitaguchi, Keiichiro Okuhira, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790125
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012
- Author(s)
  Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 13 Pages: 4453-4457
- DOI
  10.1016/j.bmcl.2012.04.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048, KAKENHI-PROJECT-23790125
[Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]-azepin-6-one skeleton.2012
- Author(s)
  Atsushi Aoyama
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Issue: 17 Pages: 7360-7377
- DOI
  10.1021/jm3002394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
[Journal Article] Further application of the multitemplate approach for creation of biological response modifiers : discovery of a new class of multifunctional anti-diabetic agents2011
- Author(s)
  K.Motoshima, T.Noguchi-Yachide, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Heterocycles
  
  Volume: 82 Issue: 2 Pages: 1083-1101
- DOI
  10.3987/rev-10-sr(e)7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers2011
- Author(s)
  伊藤幸裕
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19 Issue: 22 Pages: 6768-6778
- DOI
  10.1016/j.bmc.2011.09.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09667, KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790125
[Journal Article] Development of target protein-selective degradation inducer for protein knockdown2011
- Author(s)
  Yukihiro Itoh, Minoru Ishikawa, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 3229-3241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] ビタミンD受容体-コアクチベーター相互作用阻害物質の創製2011
- Author(s)
  三田裕介、橋本祐一、石川稔
- Journal Title
  
  ビタミン
  
  Volume: 85 Pages: 25-26
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Development oftarget protein-selective degradation inducerfor protein knockdown2011
- Author(s)
  Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Issue: 10 Pages: 3229-3241
- DOI
  10.1016/j.bmc.2011.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23659048
[Journal Article] Further Application of the Multi-Template Approach for Creation of Biological Response Modifiers : Discovery of a New Class of Multifunctional Anti-Diabetic Agents2011
- Author(s)
  Kazunori Motoshima, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita
- Journal Title
  
  Heterocycles 82
  
  Pages: 1083-1101
- NAID
  40018702697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenetylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists2011
- Author(s)
  K.Motoshima, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Issue: 10 Pages: 3041-3045
- DOI
  10.1016/j.bmcl.2011.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Confirmation of molecular planarity disruption effect on aqueous solubility improvement of β-naphthoflavone analogs2011
- Author(s)
  Yuji Fujita, 他5名
- Journal Title
  
  Heterocycles
  
  Volume: 83 Issue: 11 Pages: 2563-2575
- DOI
  10.3987/com-11-12352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23590003, KAKENHI-PROJECT-23790125
[Journal Article] Peroxizome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011
- Author(s)
  K.Motoshima, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Issue: 10 Pages: 3156-3172
- DOI
  10.1016/j.bmc.2011.03.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] ビタミンD受容体-コアクチベーター相互作用阻害物質の創製2011
- Author(s)
  三田裕介、橋本祐一、石川稔
- Journal Title
  
  ビタミン 85
  
  Pages: 25-26
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers2011
- Author(s)
  Yukihiro Itoh, Risa Kitaguchi, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 6768-6778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790125
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011
- Author(s)
  K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Issue: 8 Pages: 1147-1152
- DOI
  10.1016/j.febslet.2011.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
[Journal Article] Inhibition of Restriction Enzymes EcoRI, BamHI and HindIII by Phenethylphenylphthalimides Derived from Thalidomide2011
- Author(s)
  Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 59 Issue: 7 Pages: 880-884
- DOI
  10.1248/cpb.59.880
- NAID
  130000748024
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790125
[Journal Article] Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011
- Author(s)
  Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 3156-3172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011
- Author(s)
  Keiichiro Okuhira, Nobumichi Ohoka, Kimie Sai, Tomoko Nishimaki-Mogami, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto, Mikihiko Naito
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Pages: 1147-1152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790125
[Journal Article] Further Application of the Multi-Template Approach for Creation of Biological Response Modifiers : Discovery of a New Class of Multifunctional Anti-Diabetic Agents2011
- Author(s)
  Kazunori Motoshima, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 1083-1101
- NAID
  40018702697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011
- Author(s)
  Kazunori Motoshima, Minoru Ishikawa Yuichi Hashimoto, Kazuyuki Sugita
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators2010
- Author(s)
  Yusuke Mita, Kosuke Dodo, Tomomi Noguchi-Yachide, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 1712-1717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry2010
- Author(s)
  Jun-ichi Kasuga, Minoru Ishikawa, Mitsuhiro Yonehara, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 7164-7173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Novel Selective Anti-androgens with a Diphenylpentane Skeleton2010
- Author(s)
  Keisuke Maruyama, Tomomi Noguchi-Yachide, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 20 Pages: 6661-6666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Protein Knockdown Using Methyl Bestatin-ligand Hybrid Molecules : Design and Synthesis of Inducers of Ubiquitination-mediated Degradation of Cellular Retinoic Acid-Binding Proteins2010
- Author(s)
  Yukihiro Itoh, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto
- Journal Title
  
  J.Am.Chem.Soc. 132
  
  Pages: 5820-5826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecules : design andsynthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Journal Title
  
  J. Amer. Chem. Soc
  
  Volume: 132 Issue: 16 Pages: 5820-5826
- DOI
  10.1021/ja100691p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092
[Journal Article] Novel Selective Anti-androgens with a Diphenylpentane Skeleton2010
- Author(s)
  Keisuke Maruyama, Tomomi Noguchi-Yachide, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 6661-6666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Novel selective anti-androgens with a diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, T.Noguchi-Yachide, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 20 Issue: 22 Pages: 6661-6666
- DOI
  10.1016/j.bmcl.2010.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin Dreceptor with coactivators2010
- Author(s)
  Mita, Y., Dodo, K., Noguchi-Yachide, T, Miyachi, M., Makishima, M., Hashimoto, Y., Ishikawa, M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 20
  
  Pages: 1712-1717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry2010
- Author(s)
  Jun-ichi Kasuga, Minoru Ishikawa, Mitsuhiro Yonehara, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18 Pages: 7164-7173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Journal Article] Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists2009
- Author(s)
  Kazunori Motoshima, Tomomi Noguchi-Yachide, kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 5001-5014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 標的タンパク質を分解する低分子PROTACの創製2023
- Author(s)
  石川稔
- Organizer
  日本農芸化学会2023年広島大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Novel drug discovery for neurodegenerative disorders2023
- Author(s)
  石川稔
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Medicinal chemistry for neurodegenerative disorders2023
- Author(s)
  Minoru Ishikawa
- Organizer
  8th Seoul National University Symposium on Medicinal Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] シャペロン介在型オートファジー誘導手法の開発2022
- Author(s)
  早川英佑, 山下博子, 佐藤伸一, 橋本祐一, 出水庸介, 石川稔, 友重秀介
- Organizer
  日本ケミカルバイオロジー学会第16年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2022
- Author(s)
  中根啓太, 宮野翔伍, 友重秀介, 石川稔, 佐藤伸一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 脳移行性改善を指向したPROTACから疎水性タグへの構造展開2022
- Author(s)
  平井景梧, 山下博子, 友重秀介, 三島祐悟, 佐藤伸一, 橋本祐一, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ミトコンドリア内タンパク質選択的分解技術の開発2022
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of technology for selective degradation of proteins in mitochondrial matrix2022
- Author(s)
  Wakana Yamada, Shinichi Sato, Minoru Ishikawa, Shusuke Tomoshige
- Organizer
  The International Symposium in Tokyo 2022 Ubiquitin New Frontier
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] プロテアーゼClpPのハイジャックによるミトコンドリア内タンパク質の選択的分解技術2022
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] タンパク質分解の創薬2022
- Author(s)
  石川稔
- Organizer
  東京薬科大学生命科学部公開講義
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2022
- Author(s)
  中根啓太、宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 標的タンパク質を分解誘導する低分子2022
- Author(s)
  石川稔
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質を分解誘導する低分子2022
- Author(s)
  石川稔
- Organizer
  第74回日本細胞生物学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 水溶性向上による実用的な蛍光プローブの開発2022
- Author(s)
  神保大地, 友重秀介, 佐藤伸一, 花岡健二郎, 宮本和範, 松本洋太郎, 石川稔
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 水溶性向上による実用的な蛍光プローブの開発2022
- Author(s)
  神保大地, 友重秀介, 佐藤伸一, 花岡健二郎, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 疾患関連タンパク質を分解誘導する低分子2022
- Author(s)
  石川稔
- Organizer
  令和3年度第四回東名産学官・医連携研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2022
- Author(s)
  中根啓太、宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Chemical biology of bioactive molecules2022
- Author(s)
  Minoru Ishikawa
- Organizer
  International Symposium for Interface Oral Health Science 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 脳移行性改善を指向したPROTACから疎水性タグへの構造展開2022
- Author(s)
  平井景梧, 山下博子, 友重秀介, 三島祐悟, 佐藤伸一, 橋本祐一, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 光照射により細胞膜透過ペプチドの直接膜透過を促進するアゾ化合物2022
- Author(s)
  川崎湧至, 森本淳基, 長澤明, 阪井貴之, 大橋一正, 橋本祐一, 友重秀介, 佐藤伸一, 石川稔
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 水溶性向上による実用的な蛍光プローブの開発2022
- Author(s)
  神保大地, 友重秀介, 佐藤伸一, 花岡健二郎, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疾患関連タンパク質を分解誘導する低分子2022
- Author(s)
  石川稔
- Organizer
  令和3年度第四回東名産学官・医連携研究会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] チロシン残基修飾法によるヒト血清アルブミンの機能化2022
- Author(s)
  小原紗月, 中根啓太, 藤村千鶴, 友重秀介, 石川稔, 佐藤伸一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] グリコシル化を基盤とした凝集タンパク質可溶化法の開発2022
- Author(s)
  樋口凛, 中根啓太, 友重秀介, 佐藤伸一, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 脳移行性改善を指向した変異huntingtin分解薬の構造展開2022
- Author(s)
  平井景梧, 山下博子, 友重秀介, 三島祐悟, 佐藤伸一, 橋本祐一, 石川稔
- Organizer
  創薬懇話会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] チロシン残基修飾反応による糖構造導入を基盤としたアミロイドβの凝集抑制・可溶化2022
- Author(s)
  樋口凛, 中根啓太, 佐藤伸一, 友重秀介, 石川稔
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] チロシン残基修飾法によるヒト血清アルブミンの機能化2022
- Author(s)
  小原紗月, 中根啓太, 藤村千鶴, 友重秀介, 石川稔, 佐藤伸一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2022
- Author(s)
  中根啓太, 宮野翔伍, 友重秀介, 石川稔, 佐藤伸一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] タンパク質分解薬の創製研究2022
- Author(s)
  石川稔
- Organizer
  第54回若手ペプチド夏の勉強会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Chemical biology of bioactive molecules2022
- Author(s)
  Minoru Ishikawa
- Organizer
  International Symposium for Interface Oral Health Science 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] PROTACs for neurodegenerative disorders2022
- Author(s)
  Minoru Ishikawa
- Organizer
  Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] グリコシル化を基盤とした凝集タンパク質可溶化法の開発2022
- Author(s)
  樋口凛, 中根啓太, 友重秀介, 佐藤伸一, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Development of proximity labeling via histidine oxidation by singlet oxygen and Fc-selective functionalization of antibody2021
- Author(s)
  Keita Nakane, Tatsuya Niwa, Michihiko Tsushima, Hideki Taguchi, Shusuke Tomoshige, Hiroyuki Nakamura, Minoru Ishikawa, Shinichi Sato
- Organizer
  The 10th Annual Conference of The International Chemical Biology Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 一重項酸素を駆使したヒスチジン残基近接標識法2021
- Author(s)
  中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔、佐藤伸一
- Organizer
  第53回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 一重項酸素を活用したヒスチジン残基近接標識法の開発2021
- Author(s)
  中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔、佐藤伸一
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 分子間相互作用低下による生物活性物質の水溶性向上策2021
- Author(s)
  石川稔
- Organizer
  日本薬学会第141回年会シンポジウム薬学領域に貢献するメディシナルケミストリー最前線
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 一重項酸素を活用したヒスチジン残基化学修飾2021
- Author(s)
  佐藤伸一、中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疎水性タグ化合物による神経変性疾患関連タンパク質の分解誘導2021
- Author(s)
  平井景梧、山下博子、友重秀介、三島祐悟、佐藤伸一、橋本祐一、石川稔
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質を分解誘導するケミカルバイオロジー手法2021
- Author(s)
  石川稔
- Organizer
  日本薬学会第141回年会シンポジウム薬学領域に貢献するメディシナルケミストリー最前線
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Conversion of A PROTAC Mutant Huntingtin Degrader into Small-molecule Hydrophobic Tags Focusing on Druglike Properties2021
- Author(s)
  Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Kenji Ohgane, Shinichi Sato, Yuichi Hashimoto, Minoru Ishikawa
- Organizer
  13th AFMC INTERNATIONAL MEDICINAL CHEMISTRY SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Fc region-selective antibody labeling using ruthenium photocatalyst-functionalized affinity beads2021
- Author(s)
  Nakane Keita、Sato Shinichi、Tsushima Michihiko、Niwa Tatsuya、Taguchi Hideki、Ishikawa Minoru、Nakamura Hiroyuki
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疎水性タグ法による凝集性タンパク質のケミカルノックダウン2021
- Author(s)
  平井景梧、山下博子、友重秀介、佐藤伸一、橋本祐、石川稔
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Site-selective antibody fluorescentlabeling using single-electron transfer reaction2021
- Author(s)
  Shinichi Sato, Keita Nakane, Masaki Matsumura, Minoru Ishikawa, Hiroshi Ueda, Hiroyuki Nakamura
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2021
- Author(s)
  中根啓太、宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疎水性タグ化合物による神経変性疾患関連タンパク質の分解誘導2021
- Author(s)
  平井景梧、山下博子、友重秀介、三島祐悟、佐藤伸一、橋本祐一、石川稔
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Development of proximity labeling via histidine oxidation by singlet oxygen and Fc-selective functionalization of antibody2021
- Author(s)
  Keita Nakane, Tatsuya Niwa, Michihiko Tsushima, Hideki Taguchi, Shusuke Tomoshige, Hiroyuki Nakamura, Minoru Ishikawa, Shinichi Sato
- Organizer
  The 10th Annual Conference of The International Chemical Biology Society
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Site-selective antibody fluorescentlabeling using single-electron transfer reaction2021
- Author(s)
  Shinichi Sato, Keita Nakane, Masaki Matsumura, Minoru Ishikawa, Hiroshi Ueda, Hiroyuki Nakamura
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 細胞内で標的タンパク質を減少させる機能性分子2021
- Author(s)
  石川稔
- Organizer
  日本薬学会第141回年会シンポジウム薬学における生命指向型化学（機能性分子を基軸とした生命現象の可視化・解明）
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素laccaseを用いた高効率チロシン残基特異的修飾2021
- Author(s)
  中根啓太、宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 神経変性疾患の原因タンパク質分解薬の創製2021
- Author(s)
  石川稔
- Organizer
  CBI学会第424回研究講演会「プロテインノックダウン法による創薬パラダイムシフト」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 凝集性タンパク質を分解するストラテジー2021
- Author(s)
  石川稔
- Organizer
  第40回日本認知症学会学術集会オンラインシンポジウム新しいケミカルバイオロジー手法の開発と神経変性疾患への展開
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 分子間相互作用低下による生物活性物質の水溶性向上策2021
- Author(s)
  石川稔
- Organizer
  日本薬学会第141回年会シンポジウム薬学領域に貢献するメディシナルケミストリー最前線
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 酸化酵素を用いた高効率チロシン残基修飾反応2021
- Author(s)
  中根啓太、宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  生体機能関連化学部会若手の会　第32回サマースクール
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 一重項酸素を駆使したヒスチジン残基近接標識法2021
- Author(s)
  中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔、佐藤伸一
- Organizer
  第53回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 一重項酸素を活用したヒスチジン残基化学修飾2021
- Author(s)
  佐藤伸一、中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質を分解誘導するケミカルバイオロジー手法2021
- Author(s)
  石川稔
- Organizer
  第93回日本生化学会大会シンポジウム「化学で攻める新しい創薬のカタチ」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 一重項酸素を活用したヒスチジン残基近接標識法の開発2021
- Author(s)
  中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔、佐藤伸一
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ユビキチンリガーゼCRLSkp2を利用したハンチントン病原因タンパク質分解誘導薬の開発2021
- Author(s)
  川崎湧至、杉山実紅、佐藤伸一、石川稔、友重秀介
- Organizer
  第32回万有仙台シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 細胞内で標的タンパク質を減少させる機能性分子2021
- Author(s)
  石川稔
- Organizer
  日本薬学会第141回年会シンポジウム薬学における生命指向型化学（機能性分子を基軸とした生命現象の可視化・解明）
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 神経変性疾患の原因タンパク質分解薬の創製2021
- Author(s)
  石川稔
- Organizer
  CBI学会第424回研究講演会「プロテインノックダウン法による創薬パラダイムシフト」
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 80.Ru錯体担持アフィニティービーズを用いた抗体のFc領域選択的ヒスチジン残基修飾法の開発2021
- Author(s)
  中根啓太、丹羽達也、對馬理彦、田口英樹、友重秀介、中村浩之、石川稔、佐藤伸一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 細胞内の標的タンパク質を減少させる低分子2020
- Author(s)
  石川稔
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 標的タンパク質を分解誘導するケミカルバイオロジー手法2020
- Author(s)
  石川稔
- Organizer
  第93回日本生化学会大会シンポジウム「化学で攻める新しい創薬のカタチ」
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 新規修飾剤開発によるチロシン残基選択的修飾2020
- Author(s)
  宮野翔伍、友重秀介、石川稔、佐藤伸一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 細胞内の標的タンパク質を減少させる低分子2020
- Author(s)
  石川稔
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 疾患関連タンパク質のケミカルノックダウンと神経変性疾患への展開2020
- Author(s)
  石川稔
- Organizer
  大正製薬株式会社講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 低分子によるタンパク質ノックダウン2019
- Author(s)
  石川稔
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Degradation of target proteins by small molecules2019
- Author(s)
  石川稔
- Organizer
  17th Annual Congress of International Drug Discovery Science & Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質の寿命を短縮する低分子2019
- Author(s)
  石川稔
- Organizer
  第13回バイオ関連化学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 標的タンパク質のケミカルノックダウンと応用展開2019
- Author(s)
  石川稔
- Organizer
  日本薬学会第139年会　シンポジウム：選択的蛋白質分解医薬品開発の最前線
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 低分子創薬の守備範囲を拡げる有機化学的戦略：標的タンパク質のケミカルノックダウンと、水溶性を向上させる分子設計2019
- Author(s)
  石川稔
- Organizer
  東京理科大学理工学部生物有機化学特別セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 低分子創薬の守備範囲を拡げる有機化学的戦略：標的タンパク質のケミカルノックダウンと、水溶性を向上させる分子設計2019
- Author(s)
  石川稔
- Organizer
  東京理科大学理工学部生物有機化学特別セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質の寿命を短縮する低分子2019
- Author(s)
  石川稔
- Organizer
  第13回バイオ関連化学シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ワルなタンパク質をぶっ壊す小柄な薬2019
- Author(s)
  石川稔
- Organizer
  第9回CSJ化学フェスタ2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 低分子によるタンパク質ノックダウン2019
- Author(s)
  石川稔
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ワルなタンパク質をぶっ壊す小柄な薬2019
- Author(s)
  石川稔
- Organizer
  第9回CSJ化学フェスタ2019
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疾患関連タンパク質のケミカルノックダウンと神経変性疾患への展開2019
- Author(s)
  石川稔
- Organizer
  大正製薬株式会社講演会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質のケミカルノックダウンと応用展開2019
- Author(s)
  石川稔
- Organizer
  日本薬学会第139年会　シンポジウム　選択的タンパク質分解医薬品開発の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-17K19476
[Presentation] 細胞内の疾患関連タンパク質を減少させる有機化学的手法2019
- Author(s)
  石川稔
- Organizer
  2019年度後期（秋季）有機合成化学講習会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 細胞内の疾患関連タンパク質を減少させる有機化学的手法2019
- Author(s)
  石川稔
- Organizer
  2019年度後期（秋季）有機合成化学講習会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Degradation of target proteins by small molecules2019
- Author(s)
  石川稔
- Organizer
  17th Annual Congress of International Drug Discovery Science & Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 小さな発蛍光性反応基を用いるアフィニティーラベル化法の開発2018
- Author(s)
  山口卓男、千葉幸介、淺沼三和子、岡田佳那、石川稔、橋本祐一、どど孝介、袖岡幹子、小比賀聡
- Organizer
  第68回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] ポリグルタミン病原因タンパク質を分解誘導する低分子の創製2018
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第113回有機合成シンポジウム2018年【春】
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 低分子創薬の守備範囲を拡げる戦略：標的タンパク質のケミカルノックダウンと、水溶性を向上させる分子設計2018
- Author(s)
  石川稔
- Organizer
  名古屋大学大学院創薬科学研究科主催第79回創薬科学セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ER downregulation の母核横断的な構造活性相関2018
- Author(s)
  南條舜、谷内出友美、吉岡広大、槇島誠、石川稔、橋本祐一、大金賢司
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] ユビキチン化により標的タンパク質を分解する低分子2018
- Author(s)
  石川稔
- Organizer
  第１回ユビキチン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19476
[Presentation] 凝集性タンパク質分解における疎水性タグの有効性の検討2018
- Author(s)
  山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
- Organizer
  第75回有機合成化学協会関東支部シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19476
[Presentation] 標的タンパク質のケミカルノックダウン2018
- Author(s)
  石川稔
- Organizer
  大塚創薬化学シンポジウム2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] ユビキチン化により標的タンパク質を分解する低分子2018
- Author(s)
  石川稔
- Organizer
  第１回ユビキチン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Transrepression作用選択的PPARγリガンドの創製を指向した構造活性相関研究2018
- Author(s)
  豊田洋介、野村さやか、槇島誠、橋本祐一、石川稔
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 疾患関連タンパク質の寿命を縮める低分子2018
- Author(s)
  石川稔
- Organizer
  物質生命化学科第７回生命化学セミナー　熊本大学工学部
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 薬らしい物性を指向した核内受容体リガンドの創製研究2018
- Author(s)
  石川稔
- Organizer
  日本レチノイド研究会第29回学術集会若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 低分子創薬のフィールドを拡げる手法開発：タンパク質分解誘導薬と水溶性向上策2018
- Author(s)
  石川稔
- Organizer
  新適塾「未来創薬への誘い」第42回
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質のケミカルノックダウン2018
- Author(s)
  石川稔
- Organizer
  理化学研究所 Pioneering Project: Chemical Probe（生命現象探索分子）第一回合同合宿セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 分子構造を幾何学的非対称とする化学修飾を用いた低分子の水溶性向上策2018
- Author(s)
  森本淳基、市川裕樹、槇島誠、橋本祐一、石川稔
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 対称分子構造を非対称構造とする化学修飾を用いた核内受容体リガンドの水溶性向上策2018
- Author(s)
  森本淳基、宮本和範、市川裕樹、内山真伸、槇島誠、橋本祐一、石川稔
- Organizer
  日本レチノイド研究会第29回学術集会
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Selective degradation of target proteins by small molecules2018
- Author(s)
  Minoru Ishikawa
- Organizer
  The Third A3 Roundtable Meeting on Chemical Probe Research Hub
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 対称分子構造を非対称構造とする化学修飾を用いた低分子化合物の水溶性向上策2018
- Author(s)
  森本淳基、宮本和範、市川裕樹、内山真伸、槇島誠、橋本祐一、石川稔
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] イトラコナゾールのNPC1 に対するシャペロン作用に着目した構造活性相関研究2018
- Author(s)
  安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 低分子創薬の守備範囲を拡げる戦略：標的タンパク質のケミカルノックダウンと、水溶性を向上させる分子設計2018
- Author(s)
  石川稔
- Organizer
  第23回神戸ポートアイランド創薬フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 低分子創薬のフィールドを拡げる手法開発：タンパク質分解誘導薬と水溶性向上策2018
- Author(s)
  石川稔
- Organizer
  新適塾「未来創薬への誘い」第42回
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] 標的タンパク質のケミカルノックダウン2018
- Author(s)
  石川稔
- Organizer
  理化学研究所 Pioneering Project: Chemical Probe（生命現象探索分子）第一回合同合宿セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K19476
[Presentation] 低分子創薬の守備範囲を拡げる戦略：標的タンパク質のケミカルノックダウンと、水溶性を向上させる分子設計2018
- Author(s)
  石川稔
- Organizer
  名古屋大学大学院創薬科学研究科主催第79回創薬科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] ポリグルタミン病原因タンパク質を分解誘導する低分子の創製2018
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第113回有機合成シンポジウム2018年【春】
- Data Source
  KAKENHI-PROJECT-18H02551
[Presentation] Chemical knockdown of aggregate-prone protein associated with Huntington’s disease2018
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Hiroko Yamashita, Yuichi Hashimoto, Minoru Ishikawa
- Organizer
  2018 International Symposium on Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 幾何学的対称の分子構造に非対称性を付与することによる低分子化合物の水溶性向上策2018
- Author(s)
  森本淳基、市川裕樹、槇島誠、橋本祐一、石川稔
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Selective degradation of target proteins by small molecules2018
- Author(s)
  石川稔
- Organizer
  The Third A3 Roundtable Meeting on Chemical Probe Research Hub
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質のリン酸化を選択的に誘導する分子の創製2017
- Author(s)
  境太希、岡崎翔吾、石川稔、橋本祐一、山口卓男
- Organizer
  日本薬学会136年会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Phenanthridin-6(5H)-one骨格を有する非ステロイド型プロゲステロン受容体拮抗薬の創製2017
- Author(s)
  西山郵子、森修一、槇島誠、藤井晋也、影近弘之、橋本祐一、石川稔
- Organizer
  日本レチノイド研究会第28回学術集会
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 神経変性疾患原因タンパク質のケミカルノックダウン2017
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Development of Liver X Receptor β (LXRβ)-Selective agonists as therapeutic agents to treat atherosclerosis2017
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Toshiaki Ishizuka, Makoto Makishima, Yuichi Hashimoto and Minoru Ishikawa
- Organizer
  第９０回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] ポリQ関連タンパク質に対するプロテインノックダウン法の一般性の検討2017
- Author(s)
  山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
- Organizer
  日本薬学会136年会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] transrepression作用を指標としたPPARγリガンドの構造活性相関2017
- Author(s)
  豊田洋介、野村さやか、槇島誠、橋本祐一、石川稔
- Organizer
  日本薬学会136年会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 光照射によるアゾ化合物の水溶性向上2017
- Author(s)
  石川稔、大園拓哉、山口卓男、則包恭央
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 二置換ベンゼンの位置異性体に着目した水溶性向上策の提案2017
- Author(s)
  市川裕樹、平松道晶、三田裕介、増本優衣、松本洋太郎、村中厚哉、内山真伸、橋本祐一、石川稔
- Organizer
  日本薬学会137年会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 神経変性疾患関連凝集タンパク質を標的とした分解誘導剤の創製2017
- Author(s)
  野村さやか、友重秀介、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第11回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 神経変性疾患原因タンパク質のケミカルノックダウン2017
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K19476
[Presentation] 神経変性疾患関連凝集タンパク質分解誘導剤の開発2017
- Author(s)
  山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 神経変性疾患原因タンパク質の分解誘導薬の創製2017
- Author(s)
  石川稔
- Organizer
  国際フォトテラノスティクス共同研究教育拠点　第10回ナノバイオ若手ネットワーキングシンポジウム
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 二置換ベンゼンの構造物性相関と水溶性向上策の提案2016
- Author(s)
  市川裕樹、平松道晶、三田裕介、松本洋太郎、村中厚哉、内山真伸、橋本祐一、石川稔
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出2016
- Author(s)
  山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] タンパク質を特異的に分解する低分子の新展開2016
- Author(s)
  石川稔
- Organizer
  第３０回バイオテクノロジー懇談会
- Place of Presentation
  東京大学中島董一郎記念ホール（東京都文京区）
- Year and Date
  2016-02-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出．2016
- Author(s)
  山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] ハンチントン病原因タンパク質の分解誘導薬の創製2016
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第３４回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] ハンチントン病原因タンパク質の分解誘導薬の創製．2016
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Huntingtinタンパク質を減少させるSNIPER化合物の創製2016
- Author(s)
  友重秀介、大金賢司、内藤幹彦、石川稔、橋本祐一
- Organizer
  日本薬学会136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 「匠の化合物」で生命を操れるか？2016
- Author(s)
  石川稔
- Organizer
  第６回CSJ化学フェスタ２０１６
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2016-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Huntingtinタンパク質を減少させるSNIPER化合物の創製2016
- Author(s)
  友重秀介、大金賢司、内藤幹彦、石川稔、橋本祐一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of silicon-based biological active compounds by focusing on silyl functionality as a cis-olefin mimetic2015
- Author(s)
  Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto, Shinya Fujii
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii convention center (Hawaii, USA)
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Discovery and optimization of distinctive nuclear receptors modulators (I): Inhibitors of the interaction of VDR with coactivators, and nuclear receptors-degradation inducers2015
- Author(s)
  Minoru Ishikawa, Yusuke Mita, Yukihiro Itoh, Risa Kitaguchi, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptors modulators (II): Transrepression selective LXR ligands, and LXRβ selective agonists2015
- Author(s)
  Minoru Ishikawa, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Kazunori Motoshima, Makoto Makishima, Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids/レチノイド研究会第26回学術集会
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Development of transrepression-selective liver X receptor (LXR) ligands2015
- Author(s)
  S. Nomura, K. Endo-Umeda, A. Aoyama, M. Ishikawa, M. Makishima, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 亜鉛錯体の光学特性を利用したタンパク質破壊法の開発2015
- Author(s)
  佐藤玄、大井未来、今堀龍志、滝田良、吉田健吾、石川稔、橋本祐一、村中厚哉、内山真伸
- Organizer
  日本薬学会135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] ステロール代謝酵素CYP27A1による7-デヒドロコレステロール代謝産物の同定及び核内受容体LXRの転写活性化能に対する影響2015
- Author(s)
  梅田（遠藤）香織、安田佳織、杉田和幸、本多彰、太田美穂、石川稔、橋本祐一、榊利之、槇島誠
- Organizer
  日本分子生物学会・日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究2015
- Author(s)
  福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
- Organizer
  日本薬学会135年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015
- Author(s)
  岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓
- Organizer
  第３３回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] フェナンスリジノン骨格を有するステロイドホルモン受容体リガンドの創製2015
- Author(s)
  西山郵子、藤井晋也、石川稔、橋本祐一、槇島誠
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression作用選択的なLXRリガンドの創製2015
- Author(s)
  野村さやか、遠藤（梅田）香織、青山惇、槇島誠、橋本祐一、石川稔
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and Optimization of Non-canonical Nuclear Receptors Modulators2015
- Author(s)
  Minoru Ishikawa, Yusuke Mita, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  0th AFMC International Medicinal Chemistry Symposium (AIMECS2015)
- Place of Presentation
  International convention center (Jeju, Korea)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Polypharmacological profiles of phenanthridinone derivatives2015
- Author(s)
  Yuko Nishiyama, Takashi Misawa, Hiroshi Aoyama, Shinya Fujii, Minoru Ishikawa, Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii convention center (Hawaii, USA)
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Development of silicon-based biological active compounds by focusing on silyl functionality as a cis-olefin mimetic2015
- Author(s)
  D. Kajita, M. Nakamura, Y. Matsumoto, M. Ishikawa, Y. Hashimoto, S. Fujii
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015
- Author(s)
  岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptor modulators (II): Transrepression selective LXR ligands, and LXRβ selective agonists2015
- Author(s)
  Minoru Ishikawa, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Kazunori Motoshima, Makoto Makishika, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression 作用選択的なLXRリガンドの創製2015
- Author(s)
  野村さやか、梅田(遠藤) 香織、青山淳、槇島誠、橋本祐一、石川稔
- Organizer
  第３３回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Polypharmacological profiles of phenathridinone derivatives2015
- Author(s)
  Y. Nishiyama, T. Misawa, H. Aoyama, S. Fujii, M. Ishikawa, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] HaloTag融合標的タンパク質の存在量を減少させる汎用ケミカルツールの創製2015
- Author(s)
  友重秀介、内藤幹彦、橋本祐一、石川稔
- Organizer
  第５回CSJ化学フェスタ２０１５
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-10-13
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Discovery and optimization of distinctive nuclear receptors modulators (I): Inhibitors of the interaction of VDR with coactivators, and nuclear receptors degradation inducers2015
- Author(s)
  Minoru Ishikawa, Yusuke Mita, Yukihiro Itoh, Risa Kitaguchi, Makoto Makishima, Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids/レチノイド研究会第26回学術集会
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Improvement in Aqueous Solubility of Small Molecules by Disruption of Molecular Planarity and Bending the Molecular Structure2015
- Author(s)
  Minoru Ishikawa Yuji Fujita, Jun-ichi Kasuga, Michiaki Hiramatsu, Yuki Ichikawa, Shusuke Tomoshige, Mitsuhiro Yonehara, Takao Yamaguchi, and Yuichi Hashimoto
- Organizer
  10th AFMC International Medicinal Chemistry Symposium (AIMECS2015)
- Place of Presentation
  International convention center (Jeju, Korea)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Development of transrepression-selective liver X receptor (LXR) ligands2015
- Author(s)
  Sayaka Nomura, Kaori Endo-umeda, Atushi Aoyama, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii convention center (Hawaii, USA)
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製2015
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
- Organizer
  日本薬学会135年会
- Place of Presentation
  デザインクリエイティブセンター神戸（兵庫県神戸市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング2014
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第３２回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] LXR (Liver X Receptor)β選択的アゴニストの創製2014
- Author(s)
  野村さやか、石川稔、橋本祐一、梅田香織、槇島誠
- Organizer
  第３２回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] LXR (Liver X Receptor)β選択的アゴニストの創製2014
- Author(s)
  野村さやか、石川稔、橋本祐一、梅田香織、槇島誠
- Organizer
  第３２回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング2014
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第３２回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] ステロール代謝酵素CYP27A1による7-デヒドロコレステロール代謝産物の同定及び核内受容体LXRの転写活性化能に対する影響2014
- Author(s)
  梅田（遠藤）香織、安田佳織、杉田和幸、本多彰、太田美穂、石川稔、橋本祐一、榊利之、槇島誠
- Organizer
  第３６回胆汁酸研究会
- Place of Presentation
  東海大学（東京都千代田区）
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] 膠芽腫幹細胞を標的としたsirtuin2 阻害剤の創製研究2014
- Author(s)
  境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Transrepression作用選択的なLXR(Liver X Receptor)リガンドの創製2014
- Author(s)
  野村さやか、石川稔、青山惇、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第２５回学術集会
- Place of Presentation
  秋田大学医学部総合研究棟（秋田県秋田市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] Transrepression作用選択的なLXR(Liver X Receptor)リガンドの創製2014
- Author(s)
  野村さやか、石川稔、青山惇、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第２５回学術集会
- Place of Presentation
  秋田大学（秋田県秋田市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の評価2013
- Author(s)
  奥平桂一郎、大岡伸通、最上(西巻)知子、伊藤幸裕、石川稔、橋本祐一、内藤幹彦
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究2013
- Author(s)
  友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究2013
- Author(s)
  友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteosomal degradation of target protein2012
- Author(s)
  M. Naito, K. Okuhira, N. Ohoka, N. Shibata, T. Hattori, Y. Itoh, M. Ishikawa, Y. Hashimoto
- Organizer
  The Sixth International Conference. SUMO, Ubiquitin, UBL Proteins
- Place of Presentation
  Houston
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins, The Sixth International Conference SUMO, Ubiquitin2012
- Author(s)
  Mikihiko Naito, Keiichiro Okuhira, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto
- Organizer
  UBL Proteins:Implications for Human Diseases
- Place of Presentation
  Houston, TX, United States ofAmerica
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Development of Hybrid Small Molecules That Induce IAP-Mediated Ubiquitylation and Proteasomal Degradation of Target Proteins in a Specific Manner2012
- Author(s)
  M. Naito, K. Okuhira, Y. Demizu, Y. Itoh, M. Ishikawa, N. Ohoka, N. Shibata, T. Hattori, T. Nishimaki-Mogami, M. Kurihara, Y. Hashimoto
- Organizer
  Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
- Place of Presentation
  Cambridge, MA
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] タンパク質を特異的に分解する低分子の創製と応用2012
- Author(s)
  石川稔
- Organizer
  東京大学分子細胞生物学研究所第17回分生研シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-10-29
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins.2012
- Author(s)
  Mikihiko Naito, Keiichiro Okuhira, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto
- Organizer
  The Sixth International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
- Place of Presentation
  Houston, USA
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012
- Author(s)
  青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Improvement in solubility of bicyclic molecules focusing on dihedral angle and symmetry2012
- Author(s)
  Minoru Ishikawa, Yuichi Hashimoto
- Organizer
  243rd American Chemical Society National Meeting & Exposition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法2012
- Author(s)
  石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法2012
- Author(s)
  石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] ジフェニルペンタン骨格を有する選択的抗アンドロゲン物質の創製研究2011
- Author(s)
  丸山慶輔、谷内出友美、杉田和幸、橋本祐一、石川稔
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] LXR依存的なTransrepression作用選択的リガンドの創製2011
- Author(s)
  青山惇、遠藤香織、谷内出友美、青山洋史、石川稔、槇島誠、宮地弘幸、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] ジフェニルペンタン骨格を有する選択的抗アンドロゲン物質の創製研究2011
- Author(s)
  丸山慶輔、谷内出友美、杉田和幸、橋本祐一、石川稔
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックダウン法を利用した核内受容体分解誘導低分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本レチノイド研究会第22回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第22回日本レチノイド研究会　学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] プロテインノックダウン法を利用した核内受容体分解誘導低分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Protein knockdown : selective degradation of target proteins in cells using methyl bestatin-ligand hybrid molecules2011
- Author(s)
  Minoru Ishikawa, 他5名
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Protein knockdown : selective degradation of target proteins in cells using methyl bestatin-ligand hybrid molecules2011
- Author(s)
  M. Ishikawa, Y. Itoh, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Organizer
  AIMECS 2011
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein Knockdown: Selective Degradation of Target Proteins in Cells Using Methyl Bestatin-ligand Hybrid Molecules2011
- Author(s)
  Minoru Ishikawa, Yukihiro Itoh, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, Yuichi Hashimoto
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Tokyo, JAPAN
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] LXR依存的なTransrepression作用選択的リガンドの創製2011
- Author(s)
  青山惇、遠藤香織、谷内出友美、青山洋史、石川稔、槇島誠、宮地弘幸、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第22回日本レチノイド研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] LXXLL配列を模倣した核内受容体―コアクチベーター相互作用阻害物質の創製2010
- Author(s)
  三田裕介, どど孝介, 谷内出友美, 宮地弘幸, 橋本祐一, 石川稔
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックダウン法の開発2010
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第8回次世代を担う有機科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] LXXLL配列を模倣したビタミンD受容体-コアクチベーター相互作用阻害物質の創製2010
- Author(s)
  三田裕介、どど孝介、谷内出友美、宮地弘幸、橋本祐一、石川稔
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックダウン法を利用したAR 分解誘導剤の創製2010
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010
- Author(s)
  Yusuke Mita ; Kosuke Dodo ; Tomomi Noguchi-Yachide ; Hiroyuki Miyachi ; Yuichi Hashimoto ; Minoru Ishikawa
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国ハワイ
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] LXXLL配列を模倣した核内受容体-コアクチベーター相互作用阻害物質の創製2010
- Author(s)
  三田裕介, どど孝介, 谷内出友美, 宮地弘幸, 橋本祐一, 石川稔
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Selective anti-androgens with a3,3-diphenylpentane skeleton.2010
- Author(s)
  Keisuke Maruyama, Minoru Ishikawa, Tomomi Noguchi-Yachide, Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] LXRを介した抗炎症作用を有する選択的リガンドの創製2010
- Author(s)
  青山惇, 谷内出友美, 青山洋史, 石川稔, 槇島誠, 宮地弘幸, 橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discoveryof CRABP degradation inducers.2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] プロテインノックダウン法を利用したAR分解誘導剤の創製2010
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton.2010
- Author(s)
  Keisuke Maruyama ; Minoru Ishikawa ; Tomomi Noguchi-Yachide ; Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国ハワイ
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製2010
- Author(s)
  石川稔、伊藤幸裕、内藤幹彦、橋本祐一
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製2010
- Author(s)
  石川稔、伊藤幸裕、内藤幹彦、橋本祐一
- Organizer
  日本ビタミン学会第62大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックダウン法を利用した創薬指向型CRABP分解誘導剤の創製2010
- Author(s)
  伊藤幸裕、石川稔、奥平桂一郎、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discovery of CRABP degradation inducers2010
- Author(s)
  Y.Itoh, M.Ishikawa, M.Naito, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discovery of CRABP degradation inducers2010
- Author(s)
  Yukihiro Itoh, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010
- Author(s)
  Yusuke Mita, Kosuke Dodo, Tomomi Noguchi-Yachide, Hiroyuki Miyachi, Yuichi Hashimoto, Minoru Ishikawa
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 分子の非平面化・非対称化によるPPARδ部分作動薬の水溶性向上2010
- Author(s)
  石川稔、春日淳一、米原光拡、槇島誠、橋本祐一、宮地弘幸
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 低分子化合物を用いたプロテインノックアウト法の開発:CRABP分解誘導剤の創製2010
- Author(s)
  伊藤幸裕, 石川稔, 内藤幹彦, 橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, M.Ishikawa, T.Noguchi-Yachide, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Design, synthesis and evaluation of transrepression-selective ligands, bearing anti-inflammatory activity mediated by LXR.2010
- Author(s)
  Atsushi Aoyama, Tomomi Yachide, Hiroshi Aoyama, Minoru Ishikawa, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] Design, synthesis and evaluation of transrepression-selective ligands, bearing anti-inflammatory activity mediated by LXR2010
- Author(s)
  Atsushi Aoyama ; Tomomi Yachide ; Hiroshi Aoyama ; Minoru Ishikawa ; Makoto Makishima ; Hiroyuki Miyachi ; Yuichi Hashimoto
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  米国ハワイ
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 細胞内レチノイド結合タンパク質の分解を誘導する低分子の創製2010
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第59回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックダウン法の開発～低分子CRABP分解誘導剤の創製～2010
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第8回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] プロテインノックアウト法によるCRABP分解誘導剤の創製2009
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] サリドマイド誘導体におけるα-glucosidaseとLXR活性の作用分離2009
- Author(s)
  本島和典、石川稔、青山惇、谷内出友美、青山洋史、橋本祐一
- Organizer
  第129年会日本薬学会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] CRABP分解誘導剤の創製2009
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本レイチノイド研究会第20回学術集会
- Place of Presentation
  東京
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] サリドマイド誘導体におけるα-glucosidaseとLXR活性の作用分離、およびglycogen phosphorylase阻害活性2009
- Author(s)
  本島和典、石川稔、谷内出友美、杉田和幸、橋本祐一
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-21790108
[Presentation] 膠芽腫幹細胞を標的としたsirtuin2阻害剤の創製研究
- Author(s)
  境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の評価
- Author(s)
  奥平桂一郎、大岡伸通、最上（西巻）知子、伊藤幸裕、石川稔、橋本祐一、内藤幹彦
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Transrepression作用選択的なLiver X Receptor (LXR)リガンドの創製
- Author(s)
  野村さやか、石川稔、槇島誠、青山惇、橋本祐一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] タンパク質を特異的に分解誘導する低分子を利用した新治療戦略と低分子の標的タンパク質同定法
- Author(s)
  石川稔
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] Development of Hybrid Small Molecules That Induce IAP-Mediated Ubiquitylation and Proteasomal Degradation of Target Proteins in a Specific Manner
- Author(s)
  Mikihiko Naito, Keiichiro Okuhira, Yosuke Demizu, Yukihiro Itoh, Minoru Ishikawa, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko Nishimaki-Mogami, Masaaki Kurihara, Yuichi Hashimoto
- Organizer
  Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
- Place of Presentation
  Cambridge, MA, United States of America
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究
- Author(s)
  福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] タンパク質を特異的に分解する低分子の創製と応用
- Author(s)
  石川稔
- Organizer
  東京大学分子細胞生物学研究所　第１７回分生研シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Transrepression作用選択的なスチニルフェニルフタルイミド骨格を有するLXRリガンドの創製
- Author(s)
  野村さやか、石川稔、槇島誠、青山惇、橋本祐一
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法
- Author(s)
  石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第７回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] 細胞内レチノイン酸結合タンパク質（CRABP）を特異的に分解誘導する低分子の創製と新治療戦略
- Author(s)
  石川稔
- Organizer
  日本レチノイド研究会第２４回学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究
- Author(s)
  友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790125
[Presentation] Transrepression作用選択的なLiver X Receptor (LXR)リガンドの創製
- Author(s)
  野村さやか、石川稔、槇島誠、青山惇、橋本祐一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 核内受容体RORγ選択的リガンドの創製
- Author(s)
  西山郵子、中村政彦、槇島誠、中込まどか、石川稔、橋本祐一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25670053
[Presentation] タンパク質を特異的に分解誘導する低分子を利用した新治療戦略と低分子の標的タンパク質同定法
- Author(s)
  石川稔
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25293027
[Presentation] LXR（Liver X Receptor）β選択的アゴニストの創製
- Author(s)
  野村さやか、石川稔、橋本祐一、梅田（遠藤）香織、槇島誠
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025

1. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 3 results

# of Collaborated Products: 41 results
2. YACHIDE Tomomi (20401284)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SUGITA Kazuyuki (60542090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MATSUMOTO Yotaro (90420041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MISAWA Takashi (40709820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. FUJII Shinya (60389179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. Naito Mikihiko (00198011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 伊藤拓水 (30533179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 出水庸介 (90389180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. ABDELWAHID MAZIN

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NOGUCHI Tomomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
14. SATO Ken

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. SATO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. HONDA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 伊藤幸裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 友重秀介

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 大金賢司

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
20. 伊藤桜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中村浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 秋山徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 内山真伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 村中厚哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 田口英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 山口卓男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIKAWA Minoru 石川 稔

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変性タンパク質に対応する創薬モダリティPrincipal Investigator

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ミトコンドリア局在標的タンパク質分解薬の活性向上Principal Investigator

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medicinal chemisty based on proximity control of disease related proteinsPrincipal Investigator

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Chemical protein knockdown technology and cell regulation

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A novel drug discovery modality inducing tagging of disease related proteinsPrincipal Investigator

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chemical biology for cytosolic amyloid betaPrincipal Investigator

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Polypharmacology based on dynamism of the target protein

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Reverse proteomics of post-translational modifications utilizing small moleculesPrincipal Investigator

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Polypharmacological approach to hepatitis CPrincipal Investigator

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Novel strategy for medicinal chemistry utilizing protein knockdownPrincipal Investigator

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Chemical control of protein dramatype

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Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target Proteins

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Discovery of inhibitors for nuclear receptor functions with multiple mechanismsPrincipal Investigator

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ISHIKAWA Minoru 石川稔