HIRAOKA Masayasu 平岡昌和

Researcher Number	80014281
External Links
Affiliation (based on the past Project Information) *help	2002 – 2004: 東京医科歯科大学, 難治疾患研究所, 教授 1987 – 2000: 東京医科歯科大学, 難治疾患研究所, 教授 1994: Medical Research Institute, Tokyo Medical and Dental University, Department of C, 教授 1993 – 1994: 東京医科歯科大学, 難治研, 教授 1987: 東京大学, 難治疾患研究所, 教授 1986: Tokyo Medical and Dental University, Medical Research Institute, 難治疾患研究所, 教授
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Thoracic surgery
Keywords	Principal Investigator パッチ・クランプ法 / QT延長症候群 / 不活性化過程 / dominant negative suppression / ADP / HERG Kチャネル / ATP感受性Kチャネル / Transient outward current / Ca^<2+>電流 / Ca^<2+>放出 … More / 一過性外向き電流 / チャネル遺伝子 / ATP感受性K^+チャネル / 単一心室筋細胞 / 活動電位再分極相 / Inactivation process / Patch clamp method / Single ventricular myocyte / 心室筋再分極相 / Ca^<2+>ー感受性 / Ca^<2+>ー非感受性一過外向き電流 / 単ー心室筋細胞 / 活動電位再分極 / パッチクランプ法 / 心室再分極相 / Aconitine / Barium ion / Transient inward current / Delayed afterdepolarization / Triggered-activity / 不整脈の発生機序 / アコニチン / 【Ba^(2+)】イオン / 一過性内向き電流 / 遅延後脱分極 / Triggered-activity(誘発活動) / repolarization / K current suppression / acceleration of inactivation / activation process / mutant channels / HERG K channels / long QT syndrome / 遺伝子異変 / 脱活性化の促進 / 内向き整流 / 遅延整流K電流 / アシドージス / 女性ホルモン / 電位センサー / 再分極 / K電流抑制 / 不活性化の促進 / 活性化過程 / 変異チャネル / protein kinase C / adenosine / actin cytoskeleton / intracellular ATP / rundown of the channel activity / ATP-sensitive K^+ channel / アクチン細胞骨格 / 再活性化 / ATPの加水分解 / チャネル活性の失活(rundown) / 細胞内活性化因子 / ATPk感受性Kチャネル / プロティン・カイネース / ロテイン・カイネース / アデノシン / アクチン細骨格 / 細胞内ATP / チャネルのrundown / Ryanodine receptor channel / Ca^<2+> -activated Cl^- -channel / HERG K^+ channel / K^+ channel / ATP-sensitive / L-type Ca^<2+> channel / protein phosphorylation / Ca活性化Clチャネル / cGMP / α受容体 / リン酸化部位 / Caチャネル / Ca放出リヤノジン受容体 / L型Caチャネル / 蛋白リン酸化 / Cl-channel / artificial lipid bilayr / sarcoplasmic reticulum / Ryanodine receptor Ca^<2+> release channel / 隣酸化 / 小胞体 / リャノジン受容体チャネル / Cl-チャネル / 人工脂質膜 / リアノジン受容体チャネル / 筋小胞体 / patch-clamp technique / ventricular myocytes / Blocking kinetics and modes / State-dependent affinity / Na^+ channel / class I antiarrhythmic drugs / パッチ・クラプ法 / 不活性化状態親和性 / 活性化状態親和性 / イオン化型と非イオン化型薬剤 / 抗不整脈薬 / 心筋Na^+チャネル / Na^+チャネル抑制の動態 / 荷電型と非荷電型薬物 / チャネル抑制の速度 / イオン化型と非イオン化型薬物 / 使用依存性ブロック / 単離心室筋細胞 / ブロック動態と様式 / チャネル状態親和性 / Na^+チャネル / I群抗不整脈薬 / Nicorandil / ATP binding capacity / photoaffinity labeling method / Glibenclamide / Cromakalim / ATP-sensitive K^+ channel protein / K^+チャネル蛋白 / グリベンクロマイド / 単一チャネル電流 / ニコランジル / ATP結合能 / 光アフィニティラベル法 / グリベンクラミド / クロマカリム / ATP感受性K^+チャネル蛋白 / Increased internal Ca^<2+> / Ca^<2+>-influx / Delayed outward K^+ current / Whole-cell current recordings / Patch-clamp technique / Single heart cells / 遅延整流K^+電流 / Co^<2+> / 遅延外向きK^+電流 / 細胞内増加Ca^<2+> / Ca^<2+>流入 / 遅延整流外向き電流 / 全細胞電流記録 / 単一心筋細胞 / ST上昇 / カテコラミン感受性多形心室頻拍 / SCN5A / HERG / KvLQT1 / Brugada症候群 / 分化誘導 / 電気的リモデリング / Gap junction / Ca遊離チャネル / Ca感受性 / 特発性心室細動 / シタンジン / ト-センダニン / Ca^<2+>チャネル / 不整脈のシミュレ-ション / 膜電流 / コンピュ-タ・シミュレ-ション / 心室筋活動電位 … More Except Principal Investigator Caチャネル / 筋小胞体 / クロライドチャネル / 膜電位感受性色素 / クロライド電流 / microelectrode method / rabbit right atrium / reentrant tachycardia / 心不全 / 心肥大 / ミトコンドリア / イオンチャネル / X線回析法 / エクオリン / GTP結合蛋白質 / パッチクランプ法 / 興奮収縮連関 / クローン発現系 / single channel recording / BHK細胞 / CFTR / ランダウン / ATP感受性Kチャネル / Heart Failure / Remodeling / Lethal Arrhtymia / Cardiomyopathic hamster / K Channel / Ca Channel / HERG Channel / Arrhythmia / Ion Channel / 圧負荷 / ペースメーカーチャネル / 容積感受性クロールチャネル / HERG電流密度減少 / チャネル蛋白発現 / 蛋白チロシン燐酸化 / L型Caチャネル / 一過性外向きKチャネル / チャネルリモデリング / チャネル輸送 / Long QT症候群 / KCNQ1 / HERG / 遺伝子異常 / リモデリング / 致死性不整脈 / 心筋症ハムスター / Kチャネル / HERGチャネル / 不整脈 / aggravation of existing arrhythmias / echo zone / effective refractroy period / proaarrhythmia / antiarrhythmic drug / reentrat tachycardia / reentrrat tachycardia / Antiarrhythmic agent / bipolar electrode / microelectrode / proarrhythmia / antiarrhythmic agent / long QT syndrome / dilated cardiomyopathy / mitochondrial cardiomyopathy / hypertvophic cardiomyopathy / homeobox gene / mechanism of transcriptional regulation / cardiac hypertrophy / cardio-specific gene expression / アンギオテンシン / カリウムチャンネル / BNP / 心筋症 / 遺伝子発現 / 心筋細胞 / QT延長症候群 / 拡張型心筋症 / ミトコンドリア心筋症 / 肥大型心筋症 / ホメオボックス遺伝子 / 転写調節機構 / 心筋特異的遺伝子発現 / ホスホランバン / リセプター / アセチルコリン / ホスホランハン / アセチルコリン・リセプター / イオンチャンネル / アデニンヌクレオチド / 電気生理学 / 人工脂質膜 / ATP通過 / イオン透過性 / 異方向性伝導 / 洞結節異常自動能 / 細胞内カルシウム濃度 / 伸展活性化チャネル / プリン作動性チャネル / トリプシン / 短鎖アシルカルニチン / リゾフォスファチジ-ルコリン / 興奮伝播マッピング / 交感神経緊張 / アミロライド / イオン感受性電極 / 心筋虚血 / ATP感受性カリウム電流 / 筋小胞体Ca^<2+>輸送 / 細胞内Ca^<2+>動態 / 燐酸化 / 心筋収縮蛋白質 / 受容体 / Na^+チャンネル / Ca^<2+>チャンネル / 心筋興奮収縮連関 Less

致死性不整脈発症の分子基盤に関する調査・研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
心臓血管系におけるチャネル病の発症と成因に関する調査・研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ ChannelsPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Meducal and Dental University
BHK細胞へ発現させたL型Caチャネルの機能調節(2):燐酸化反応とprotein targeting
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugs
- Principal Investigator
  
  SAWANOBORI Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institute, Tokyo Medical and Dental University
BHK細胞へ発現させた心筋L型Caチャネルの機能調節とサブユニット構造
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Modulatory mechanisms of cardiac ion channels.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
Cardio-Specific Gene Expression and Genetic Analysis of Myocardial Disorders
- Principal Investigator
  
  YAZAKI Yoshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordingsPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical & Dental University, Medical Research Institute
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
Development of a ligand for purification of the ATP-sensitive K^+ channe proteinPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  TADA Michihiko
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for ArrhythmogenesisPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institution, Tokyo Medical and Dental University
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  多田道彦
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  多田道彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Study of the outward current systems of mammalian ventricular muscle cells in relation to the genesis of rhythm disturbancesPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
The study of the mechanism and characteristics of triggered-activityPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2004 2003 2002

All Journal Article

[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.2004
- Author(s)
  Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano, Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 27194-27198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.2004
- Author(s)
  E.Yanagida, S.Shoji, Y.Hirayama, F.Yoshikawa, K.Otsu, H.Uematsu, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Hiraoka M, et al.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004
- Author(s)
  T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 27-32
- NAID
  10013054366
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] The effects of K+ channel modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 189-195
- NAID
  10013054366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 189-195
- NAID
  10013294757
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia2004
- Author(s)
  Ueda K, Hiraoka M, Kimura A, et al.
- Journal Title
  
  J.Biol.Chem 279
  
  Pages: 27194-27198
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 185-195
- NAID
  10013294757
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Reentrant tachycardias in pulmonary veins of patients with paroxysmal atrial fibrillation.2003
- Author(s)
  Takahashi Y, Ieska Y, Takahashi A, Goya M, Kobayashi K, Fujiwara H, Hiraoka M.
- Journal Title
  
  Cardiovasc Electrophysiol 14
  
  Pages: 927-932
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003
- Author(s)
  Kocic I, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  Basic Res Cardiol 98
  
  Pages: 367-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ST segment elevation in the Brugada syndrome.2003
- Author(s)
  Nishizaki M, Sakurada H, Ashikaga T, Yamawake N, Fujii H, Arita M, Isobe M, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 14
  
  Pages: 243-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of recombinant KCNQ1/KCNE1 K channels (I_<KS>) by intracellular Na and its implications on action potential repolarization.2003
- Author(s)
  Orikabe M, Hirano Y, Isobe M, Hiraoka M.
- Journal Title
  
  Jpn.J.Physiol. 53
  
  Pages: 417-425
- NAID
  10012733004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Reentrant tachycardias in pulmonary veins of patients with paroxysmal atrial fibrillation.2003
- Author(s)
  Takahashi Y, Ieska Y, Takahashi A, Goya M, Kobayashi K, Fujiwara H, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 14
  
  Pages: 927-932
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Rate-dependent changes in action potential durations and membrane currents in hamster ventricular myocytes.2002
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  Pflugers Arch 443
  
  Pages: 353-361
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure lowering without affecting heart weight increase in rats with abdominal aortic banding.2002
- Author(s)
  Hiramatsu M, Furukawa T, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 39
  
  Pages: 866-874
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.2002
- Author(s)
  Nishizaki M, Ashikaga T, Yamawake N, Fujii H, Arita M, Sumitomo N, Sakurada H, Hiraoka M
- Journal Title
  
  Circ J 66
  
  Pages: 35-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] High incidence of device-related and lead-related complications in the dual-chamber implantable cardioverter defibrillator compared with the single-chamber version.2002
- Author(s)
  Takahashi T, Bhandari AK, Watanuki M, Cannom DS, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 746-750
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.2002
- Author(s)
  Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A.
- Journal Title
  
  Cardiovasc Res 53
  
  Pages: 348-354
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure Class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardias2002
- Author(s)
  Igawa M, Aonuma K, Okamoto Y, Hiroe M, Hiraoka M, Isobe M.
- Journal Title
  
  J Cardiovasc Pharmacol 40
  
  Pages: 735-742
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Opening of KATP channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty.2002
- Author(s)
  Ashikaga T, Nishizaki M, Arita M, Yamawake N, Fujii H, Kishi Y, Isobe M, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 469-472
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Opening of KATP channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty2002
- Author(s)
  Ashikaga T, Nishizaki M, Arita M, Yamawake N, Fujii H, Kishi Y, Isobe M, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 469-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Electrical connections between pulmonary veins. Implications for ostial ablation of pulmonary veins in patients with paroxyxmal atrial fibrillation.2002
- Author(s)
  Takahashi A, Iesaka Y, Takahashi Y, Takahashi R, Kobayashi K, Takagi K, Kuboyama O, Nishimori T, Takei H, Amemiya H, Fujiwara H, Hiraoka M.
- Journal Title
  
  Circulation 105
  
  Pages: 2998-3003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Electrical connection between left superior and inferior pulmonary veins in a patient with paroxysmal atrial fibrillation.2002
- Author(s)
  Takahashi Y, Iesaka Y, Takahashi A, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 13
  
  Pages: 490-492
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] High incidence of device-related and lead-related complications in the dual-chamber implantable cardioverter defibrillator compared with the single-chamber version.2002
- Author(s)
  Takahashi T, Bhandari AK, Watanuki M, Cannom DS, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66:
  
  Pages: 746-750
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.2002
- Author(s)
  Nishizaki M, Ashikaga T, Yamawake N, Fujii H, Arita M, Sumitomo N, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 35-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Moving dipole analysis of normal and abnormal ventricular activation by magnetocardiography.2002
- Author(s)
  Hiyoshi Y, Sakurada H, Izumida N, Kawano S, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Electrocardiol 35
  
  Pages: 105-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure Class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardias.2002
- Author(s)
  Igawa M, Aonuma K, Okamoto Y, Hiroe M, Hiraoka M, Isobe M.
- Journal Title
  
  J Cardiovasc Pharmacol 40
  
  Pages: 735-742
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404

1. HIRANO Yuji (00181181)

# of Collaborated Projects: 9 results

# of Collaborated Products: 17 results
2. KAWANO Seiko (00177718)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
3. SAWANOBORI Tohru (00014217)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. TADA Michihiko (90093434)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 頴原嗣尚 (50037446)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 外山淳治 (20023658)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 遠藤政夫 (40004668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 有田真 (60037364)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 神野耕太郎 (40025630)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 小川聡 (90124940)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 木村彰方 (60161551)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. HORIKAWA Saburo (10127136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 西勝英 (00040220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 堀江稔 (90183938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 野間昭典 (00132738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. YAZAKI Yoshio (20101090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAGAI Ryozo (60207975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAO Kazuwa (00172263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SASAYAMA Shigetake (70109007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KUNIYASU Akihikko (90241348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 松原一郎 (90010040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 渡部良夫 (70084572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大津欣也 (20294051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 児玉逸雄 (30124720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 岡田泰伸 (10025661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 相澤義房 (50143780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 蒔田直昌 (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 山口正人 (90313650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 宇井理生 (50001037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 芳賀達也 (30011646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 松原弘明 (10239072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 川口秀明 (70161297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. CORONAD Roberts

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. HARTZELL Criss

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. FOZZARD Harry A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 施玉りゃん

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 徐科

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. CORONADO Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRAOKA Masayasu 平岡 昌和

Research Projects

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Co-Researchers

致死性不整脈発症の分子基盤に関する調査・研究Principal Investigator

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The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator

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心臓血管系におけるチャネル病の発症と成因に関する調査・研究Principal Investigator

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Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ ChannelsPrincipal Investigator

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Modulatory mechanisms of cardiac ion channels.Principal Investigator

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Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.Principal Investigator

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Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.Principal Investigator

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心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究Principal Investigator

Principal Investigator

HIRAOKA Masayasu 平岡昌和