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KUZUMAKI Noboru  葛巻 暹

ORCIDConnect your ORCID iD *help
… Alternative Names

葛巻 〓  クズマキ ノボル

葛巻 邉  クズマキ ススム

葛巻 のぼる  クズマキ ノボル

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Researcher Number 80091445
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2000 – 2004: Hokkaido Univ.Institute for Gene.Med., Prof., 遺伝子病制御研究所, 教授
2000: 北海道大学, 大学院・医学研究科, 教授
1986 – 1999: Hokkaido University, School of Medicine, Professor, 医学部, 教授
1991: 地海道大学, 医学部, 教授
Review Section/Research Field
Principal Investigator
医薬分子機能学 / 医学一般 / Surgical dentistry / Digestive surgery / Biological Sciences / Cell biology
Except Principal Investigator
General surgery / Urology / Digestive surgery / Experimental pathology / 医学一般 / Plastic surgery / Respiratory organ internal medicine
Keywords
Principal Investigator
遺伝子治療 / 膀胱癌 / 変異体 / ゲルゾリン / 抑制変異体 / ras癌遺伝子 / β-gal / gene therapy / adenovirus / アデノウイルス … More / mutant / gelsolin / 癌抑制 / ヌードマウス / ゲルソリン / アデノウイルスベクター / 食道癌 / 腫瘍抑制 / 増殖抑制 / アクチン / monoclonal antibody / oncogene products / oncogenes / Psoriasis / 皮膚腫瘍 / 正常復帰細胞株 / マウス形質細胞腫 / mRNA / モノクローナル抗体 / 癌遺伝子産物 / 癌遺伝子 / 乾癬 / telomerase / growth suppression / tongue cancer / suppressive mutant / RAS oncogene / 口腔癌 / RAS癌遺伝子 / nude mice / bladder cancer / retrovirus / esophageal cancer / pancreatic cancer / ras gene / すい臓癌 / レトロウイルスベクター / ヒト膵癌 / ヒト食道癌 / レトロウイスル / すい癌 / human cancers / tumor suppression / 紫外線 / 細胞周期 / アポトーシス / ヒト癌 / Colon cancer / Bladder cancer / Mutants / Tumor suppression / Cell growth / Gelsolin / Actin / 胃癌 / DNA合成 / 3T3 / NIH / PIP_2 / フォスホリパーゼ / ラス癌遺伝子 / 大腸癌 / 細胞増殖 / 生物生産 / 腫瘍抗原 / がん遺伝子 / 膵癌 / RAS / 肺癌 / プロモーター / hTERT / 消化器癌 / ras遺伝子 / 耐性 / シスプラチン / 変異遺伝子 / 突然変異 / cDNAライブラリ- / ノ-ザンブロット / リバ-タント … More
Except Principal Investigator
N116Y / 遺伝子治療 / ベクター / 癌遺伝子治療 / Vector / Cancer Gene Therapy / Pancreatic Cancer / intravesical administration / ras suppressor mutant / Human bladder cancer cell lines / Ras抑制変異体 / 膀胱内注入 / ゲルゾリン / ras抑制変異体 / 膀胱癌細胞株 / CEAプロモーター / 膵癌 / アデノウイルスペクター / 食道癌 / hCG / モノクローナル抗体 / がん遺伝子 / 腫瘍抗原 / 分子生物学 / Oncogene / Cell surface modification / Tumor metastasis / Tumor regression / Tumor progression / Malignancy / Tumor cells / ウイルス感染 / 細胞融合 / DNAメチル化阻害 / 突然変異 / 転移能 / 腫瘍原性 / 細胞間コミュニケーション / 発癌遺伝子 / 細胞膜面修飾 / がん転移 / 腫瘍退縮 / 腫瘍進展 / 悪性度 / がん細胞 / enhanced effect / Regulation of expression / Gene Therapy / Gelsolin / アデノウィルスベクタ / 同所移植腫瘍 / 効果増強 / 発現制御 / molecular biology / apoptosis / intracellular signal transduction / fibroblast / keloid / MAPK / アポトーシス / 細胞内信号伝達 / 線維芽細胞 / ケロイド / Adenovirus vector / Cancer specific promoter / Cancer gene therapy / Esophageal cancer / Ras / アデノウイルスベクター / SCCAプロモーター / gelsolin / Growth suppression / Gene Transfer / 膀胱癌 / 細胞増殖抑制 / アデノウィルスベクター / 増殖抑制 / 遺伝子導入 / CEA promoter / RAS変異体 / 膵臓癌 / K-ras / p53 / RAS抑制変異体 / 癌の遺伝子治療 / choriocarcinoma / dome formation / active transport / Na^+-K^+-ATPase / trophoblast / placenta / ras oncogene / 絨毛癌 / ドーム形成 / 能動輸送 / Na^+K^+ATPase / 絨毛 / 胎盤 / ラス癌遺伝子 / Hepatic function / Warm ischemia / Human hepatocyte / Natural antibody / Hepatic failure / Culture of hepatocyte / Hybrid artificial liver system / アミノ酸代謝 / ブタ肝細胞培養 / 培養ブタ肝細胞 / バイオリアクター / 酸素分圧 / ヒト肝細胞培養 / 肝細胞機能 / 温阻血 / ヒト肝細胞 / 自然抗体 / 肝不全 / 肝細胞培養 / ハイブリッド型人工肝 / Bronchoalveolar lavage (BAL) / Sarcoidosis / Reverse transcription-polymerase chain reaction (RT-PCR) / Macrophage colony-stimulating factor (M-CSF) / Interleukin-3 (IL-3) / Granulocyte-macrophage colony-stimulating factor (GM-CSF) / BAL / PCR / MーCSF / ILー3 / GMーCSF / 逆転写ポルメア-ゼチェインリアクション / マクロファ-ジコロニ-刺激因子 / 気管支肺胞洗浄 / サルコイド-シス / 透転写ポリメア-ゼチュインリアクション / マクロファジ-コロニ-刺激因子 / インタ-ロイキン3 / 顆粒球マクロファ-ジコロニ-刺激因子 / DNA複製 / RFLP / 先天異常 / DNAポリメラーゼ / PCNA / 分子生物学的解析 / Carcinoembryonic antigen / 消化器癌関連抗原 / 分子生物学的研究 / 癌胎児性蛋白 / 癌遺伝子 / 消化器系癌抗原 / 腫瘍エスケープ機構 / キラーT細胞 / 分化・脱分極化 / 分化抗原 / キラーT細胞活性化因子 / IL-2レセプター / IL-2 / 肺癌 / ヒト原発癌 / CTL / MLPC / HLA / 癌・精巣抗原 / D40 / ras / AFP / BGP1 / NCA / CEA遺伝子 Less
  • Research Projects

    (31 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (37 People)
  •  Prechnical research on gene therapy for oral cancer using a RAS dominant negative mutantPrincipal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  「精巣と癌」のみに発現する新しい遺伝子産物の癌抗原としての役割と免疫療法への応用

    • Principal Investigator
      瀧本 将人
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  RAS抑制変異体を用いた腫瘍特異的同所性遺伝子治療モデルPrincipal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Establishment of gene therapy against bladder cancer utilizing gelsolin gene and a dominant negative ras mutant

    • Principal Investigator
      SHINOHARA Nobuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Hokkaido University
  •  アクチン調節蛋白質ゲルソリンのテロメレース抑制作用Principal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cell biology
    • Research Institution
      Hokkaido University
  •  Development of cancer specific gene therapy for esophageal carcinoma and improvement of approach for human gene therapy

    • Principal Investigator
      OKUSHIBA Shun-ichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      General surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Molecular biological analysis of the intracellular signal transduction in keloid-derived fibroblasts

    • Principal Investigator
      MINAKAWA Hidchiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Plastic surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Gene target therapy against human bladder cancer by gelsolin genePrincipal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      医薬分子機能学
    • Research Institution
      Hokkaido University
  •  Specific Gene Therapy for Pancreatic Cancer

    • Principal Investigator
      KATOH Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Preclinical study for gene therapy against bladder cancer utilizing gelsolin gene and a dominant negative ras mutant

    • Principal Investigator
      SHINOHARA Nobuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  ras抑制変異体を用いた消化器癌に対する遺伝子治療の基礎研究Principal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  New Gene Therapy for Esophageal Cancer Patients.

    • Principal Investigator
      OKUSHIBA Shun-ichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Tumor Specific Gene Therapy for Pancreatic Cancer

    • Principal Investigator
      KATOH Hiroyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Tumor suppression by using gelsolin mutantsPrincipal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Hokkaido University
  •  Clinical research of gene therapy against digestive tract cancers by using ras suppressor mutant.Principal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Hokkaido University
  •  Role of RAS oncogenes in a human chorionic cancer cell line.

    • Principal Investigator
      OGISO Yoshifumi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Shinshu University
  •  Role of actin-regulatory gelsolin in control of cell growthPrincipal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Hokkaido University
  •  シスプラチン耐性におけるras癌遺伝子の役割とその克服Principal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  ゲルゾリン遺伝子の変異と腫瘍抑制Principal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Development of hybrid artificial liver system

    • Principal Investigator
      UCHINO Junichi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Hokkaido University
  •  アクチン調節蛋白質ゲルゾリンの細胞増殖における役割に関する研究Principal Investigator

    • Principal Investigator
      葛巻 暹
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Institution
      Hokkaido University
  •  Molecular and Biological Study on Roles of Colony-Stimulating Factors in the Formation of Granulomatous Lung Lesions.

    • Principal Investigator
      YAMAGUCHI Etsuro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Hokkaido University
  •  消化器系抗原とその遺伝子に関する免疫学的・分子生物学的研究ならびに新しい応用

    • Principal Investigator
      谷内 昭
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  消化器系癌抗原とその遺伝子に関する免疫学的・分子生物学的研究なよびに新しい応用

    • Principal Investigator
      谷内 昭
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  PCNA/DNA ポリメラーゼδ補助蛋白遺伝子の異常と高発癌性遺伝性疾患

    • Principal Investigator
      守内 哲也
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  消化器系癌抗原とその遺伝子に関する免疫学的・分子生物学的研究ならびに新しい応用

    • Principal Investigator
      谷内 昭
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  がん遺伝子関連腫瘍抗原の生物生産に関する研究Principal Investigator

    • Principal Investigator
      葛巻 〓
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  The role of genes associated with cell growth in proliferating diseasesPrincipal Investigator

    • Principal Investigator
      KUZUMAKI Noboru
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      医学一般
    • Research Institution
      Hokkaido University.
  •  腫瘍抗原の発現と免疫系の認識に関する分子免疫学的解析

    • Principal Investigator
      谷口 克
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Chiba University
  •  腫瘍抗原の発現と免疫系の認識に関する分子免疫学的解析

    • Principal Investigator
      谷口 克
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Chiba University
  •  Studies on the nature of tumor cell malignancy

    • Principal Investigator
      KOBAYASHI Hiroshi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      医学一般
    • Research Institution
      Hokkaido University

All 2004 2002

All Journal Article Book Patent

  • [Book] 癌の遺伝子治療「遺伝子診断・遺伝子治療(道医シリーズ第42編)」2002

    • Author(s)
      葛巻 暹
    • Publisher
      北海道医師会
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Journal Article] Growth suppressive effect on human tongue cancer by a RAS oncogene suppressive mutant2004

    • Author(s)
      Satoshi, Kuzumaki et al.
    • Journal Title

      Hokkaido Journal of Dental Science Vol.25

      Pages: 33-44

    • NAID

      10014231485

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Journal Article] RAS癌遺伝子抑制変異体によるヒト舌癌に対する増殖抑制効果2004

    • Author(s)
      葛巻 哲 ほか
    • Journal Title

      北海道歯学雑誌 25

      Pages: 33-44

    • NAID

      10014231485

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Journal Article] 癌の遺伝子治療2002

    • Author(s)
      葛巻 暹
    • Journal Title

      北海道医報 986

      Pages: 8-12

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Patent] RAS抑制変異型タンパク質およびその遺伝子2004

    • Inventor(s)
      葛巻 暹, 七戸 俊明
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Industrial Property Number
      2003-381052
    • Filing Date
      2004-08-10
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Patent] RAS抑制変異型タンパク質及びその遺伝子2004

    • Inventor(s)
      葛巻 暹, 七戸 俊明
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2003-381052
    • Filing Date
      2004-08-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • [Patent] RAS抑制変異型タンパク質およびその遺伝子2002

    • Inventor(s)
      葛巻 暹, 七戸 俊明
    • Industrial Property Rights Holder
      科学技術振興事業団
    • Industrial Property Number
      2002-329986
    • Filing Date
      2002-11-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370651
  • 1.  TAKIMOTO Masato (30179585)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  FUJITA Hisakazu (30212187)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  KATO Hiroyuki (80002369)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  SHINOHARA Nobuo (90250422)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  KONDO Satoshi (30215454)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  谷内 昭 (50045324)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  今井 浩三 (60117603)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  森 武貞 (60028496)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  西 信三 (20001894)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  松岡 雄治 (70078773)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  OGISO Yoshifumi (50233440)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  TAKAHASHI Toshiyuki (40261284)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  OKUSHIBA Shun-ichi (70185536)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  谷口 克 (80110310)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  帯刀 益夫 (10099971)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  藤原 大美 (70116094)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  藤本 重義 (00009151)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  YAMAGUCHI Etsuro (10201831)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  UCHINO Junichi (40000989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MATUSHITA Michiaki (20250425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NAKAJIMA Yasuaki (90198101)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SUGIURA Hiroshi (30292022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  DEMURA Takayoshi (00133827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MINAKAWA Hidchiko (80229757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  CHIBA Itsuo (50250460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  NAKAGAWA Koji (80360949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  KOBAYASHI Hiroshi (20000911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  OIKAWA Tsuneyuki (80150241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  TAKEICHI Noritoshi (40002133)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  HOSOKAWA Masuo (20001901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  上出 利光 (00160185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  竹森 利忠 (60114295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  守内 哲也 (20174394)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  中根 一穂 (60164240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  MCLAUGHLIN Paul
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  JANMEY Paul
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  STOSSEL Thomas
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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