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kishihara kenji  岸原 健二

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KISHIHARA Kenji  岸原 健二

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Researcher Number 80214774
Other IDs
Affiliation (Current) 2025: 長崎国際大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2008 – 2010: Nagasaki International University, 薬学部, 教授
2007: The University of Tokushima, Institute of Health Biosciences, Graduate School, Associate Professor
2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教授
2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教授
2004: 徳島大学, ヘルスバイオサイエンス研究部, 助教授 … More
2003: 徳島大学, 医学部, 助教授
1994 – 2002: 九州大学, 生体防御医学研究所, 助手
1997: Kyusyu University Medical Insttitute of Bioregulation Research Associate, 生体防御研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Immunology / Immunology
Except Principal Investigator
Surgical dentistry / Biological Sciences / Thoracic surgery / Kidney internal medicine / 寄生虫学(含医用動物学)
Keywords
Principal Investigator
ジーンターゲティング / Notch / チロシンホスファターゼ / リンパ球 / CD45 / T細胞 / γδT細胞 / NK細胞 / 免疫異常 / Tリンパ球 … More / フリンジ / ノックアウトマウス / PCR / NK cell / クローニング / Glycosylation / Lunatic fringe / immunoregulation / T lymphocyte / Notch ligands / 機能制御 / 抗腫瘍免疫 / 糖鎖修飾 / 免疫調節 / Notchリガンド / cell sutonomous regulation / thymic organ culture / cell fate decision / gene targeting / T lymphocyte development / glycosylation / lunatic fringe / 細胞系譜決定 / 糖鎖転移酵素 / ジーン・ターゲティング / 細胞系譜 / 細胞分化 / 遺伝子改変 / 糖鎖 / Fetal thymocyte / T cell repertoire / Resident pulmonary lymphocyte / T cell development / T cell receptor / Dendritic epidermal T cell / Gene targeting / γδ T cell / 皮膚 / 分化 / レセプター / γδ / 胎仔胸腺細胞 / T細胞レパートア / T細胞の発生・分化 / T細胞レセプター / 肺上皮内T細胞 / 皮内樹状T細胞 / Gene expression / Gene targeing / Protein tyrosin phosphatase / CLONING / PROTEIN TYROSINE PHOSPHATASE / LYMPHOCYTE / Gene Targeting / B cell / T cell / Tyrosine Phosphatase / 白血球 / B細胞 / 造血幹細胞 / 胚性幹細胞 / γδTリンパ球 / 幹細胞 / 自然免疫 / Jurkat / シグナル伝達 / 遺伝子発現 / プロテインキナーゼC / p56^<lck> / p56^<1ck> … More
Except Principal Investigator
T細胞レセプター / Cytokine / T cell receptor / サイトカイン / 遺伝子クローニング / 口腔扁平上皮癌 / 免疫 / ノックアウトマウス / T細胞 / Immunology / Gene cloning / Tumor-associated antigen / Oral squamous cell carcinoma / 腫瘍関連抗原 / 細胞障害性T細胞 / Knockout mouse / CD8 / Tリンパ球 / Notch / 癌 / シグナル伝達 / Co-stimulation / Sjogren's syndrome / Oral lichen planus / Diagnosis / Antigen / Oral mucosal disease / 臨床検査 / シェーグレン症侯群 / シェーグレン症候群 / 口腔扁平苔癬 / 診断 / 抗原 / 口腔粘膜疾患 / Vaccination therapy / Cytotoxic T cell / ワクチン療法 / 細胞傷害性T細胞 / skin graft / discordant / xenografts / CD4 and CD8 knockout mice / CD4+ T cells / CD4 / 抗原認識 / Discordant異種移植 / 薬剤誘導性免疫寛容系 / キメラ / Discordant異種 / Cellular immunity / Tubulointerstitial damage / 増殖因子 / 細胞性免疫 / 尿細管間質障害 / Cytotoxic T cells / Immunity / T細胞クローン / Macrophage / Testosterone / Protective immunity / Expulsion / CD8+T cell / Mast cell / Strongyloides ratti / goblet cell / 肥満細胞 / 防御免疫 / CD8+T細胞 / マクロファージ / テストステロン / 防御免役 / 排虫 / CD8十T細胞 / 肥満細胞(MMC) / ネズミ糞線虫 / 細胞内寄生性病原体 / CTL / Th2 / Th1 / 細胞系譜決定 / 細胞分化 / 腫瘍免疫 / 膠原病 / Jagged / 樹状細胞 / 免疫療法 / 発生・分化 / 病理学 / 細胞・組織 / 免疫学 / 免疫寛容 / 不死化 / アポトーシス / コクサッキーウイルス / アデノウイルス / 関節リウマチ / JAK / 炎症性疾患 / 大腸炎 / 関節炎リウマチ / キナーゼ抑制因子 / 造血因子 / 炎症 / SOCS / STAT / チロシンキナーゼ / 脂質ラフト / 好酸球 / チロシンりん酸化 / 消化管神経 / MAPキナーゼ / Ras / チロシンキナ一ゼ / 増殖シグナル / CTLA4 / 酸化ストレス / CD45フォスファターゼ / 遺伝子欠損マウス / Srcファミリーキナーゼ / TCR-CD_3複合体 / Jak3欠損マウス / セリン・スレオニンキナーゼ / CD3結合分子 / 抗腫瘍免疫 / IL-2レセプター / Co-stimulator / Jak / Syk / CD28 / CD45 / HS1 / TCR構造異常 / T細胞活性化 Less
  • Research Projects

    (23 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (27 People)
  •  Development of a culture system to selectively induceγ δT-lymphocytes from embryonic and hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Nagasaki International University
  •  Establishment of the system to control T lymphocyte functions using Notch ligandsPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Notch分子によるヘルパーTリンパ球分化・活性化制御機構の解明

    • Principal Investigator
      MAEKAWA Yoichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  T lymphocyte-specific gene targeting of Notch receptor glycosyltransferase fringePrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokushima
  •  Jagged1を制御することによる癌免疫の増強に関する研究

    • Principal Investigator
      安友 康二
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Tリンパ球の生死を規定する分子機構の解明

    • Principal Investigator
      安友 康二
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  サイトカインのシグナル制御機構とその破綻

    • Principal Investigator
      吉村 昭彦
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Kyushu University
  •  Analysis of pathogenesis and establishment of novel diagnostic strategy of oral mucosal diseases by T cell receptorbased analysis

    • Principal Investigator
      NAKAMURA Seiji
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kyushu University
  •  Identification of oral squamous cell carcinoma-associated antigens recognized by T cells

    • Principal Investigator
      NAKAMURA Seiji
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kyushu University
  •  SELECTIVE GENE TRGETING OF TCR Vδ GENES AND ANALYSIS OF THE KNOCKOUT MICEPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYUSHU UNIVERSITY
  •  GENE TARGETING OF PROTEIN TYROSINE PHOSPHATASE PTP-JPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Identification of oral squamous cell carcinoma-associated antigens recognized by T cells

    • Principal Investigator
      NAKAMURA Seiji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kyushu University
  •  Elucidation of the immunological mechanism in tubulointerstitial damage. - investigation with knockout mouse

    • Principal Investigator
      FUKUDA Kyoichi, 安藤 高志
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  THE ANALYSIS OF THE MECHANISM OF ALLOGRAFT REJECTION USING KNOCK OUT MICES

    • Principal Investigator
      TOMITA Yukihiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  T細胞活性化のシグナル伝達

    • Principal Investigator
      斉藤 隆
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba University
  •  T細胞に発現される新しいチロシンホスファターゼの遺伝子と機能の解析Principal Investigator

    • Principal Investigator
      岸原 健二
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      Kyushu University
  •  A study of defense mechanism against the infection of intestinal nematode by using knockout mice

    • Principal Investigator
      TADA Isao
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Kyusyu University
  •  遺伝子ターゲティングマウスにおける免疫応答異常の解析Principal Investigator

    • Principal Investigator
      岸原 健二
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  T細胞活性化のシグナル伝達

    • Principal Investigator
      斉藤 隆
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba University
  •  特異遺伝子欠損マウスにおける免疫応答異常の解析Principal Investigator

    • Principal Investigator
      岸原 健二
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  T細胞活性化のシグナル伝達

    • Principal Investigator
      斉藤 隆
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Chiba University
  •  The Role of CD45 in Leukocyte Differentiation and FunctionPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYUSHU UNEVERSITY
  •  SUBTRACTION PCR CLONING OF NOVEL LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE PHOSPHATASE GENESPrincipal Investigator

    • Principal Investigator
      KISHIHARA Kenji
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYUSHU UNIVERSITY

All 2010

All Journal Article

  • [Journal Article]2010

    • Author(s)
      Alam MS、Maekawa Y、Kitamura A、Tanigaki K、Yoshimoto T、Kishihara K、Yasutomo K
    • Journal Title

      Proceedings of national academy of sciences U.S.A. 107巻

      Pages: 5943-5948

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590491
  • [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung2010

    • Author(s)
      Okamoto Yoshida Y、Umemura M、Yahagi A、O'Brien RL、Ikuta K、Kishihara K、Hara H、Nakae S、Iwakura Y、Matsuzaki G
    • Journal Title

      Journal of Immunology 184巻

      Pages: 4414-4422

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590491
  • 1.  MATSUZAKI Goro (30229455)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  YOSHIDA Hiroki (40260715)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TSUKUMO Shinichi (10346596)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  NAKAMURA Seiji (60189040)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  SHIRASUNA Kanemitsu (30093420)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  斉藤 隆 (50205655)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  南 康博 (70229772)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  高橋 秀実 (40221361)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  藤原 大美 (70116094)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  上出 利光 (00160185)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  安友 康二 (30333511)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  MAEKAWA Yoichi (10294670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  FUKUDA Kyoichi (90294925)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  FUJUKI Tsukasa (00420612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TADA Isao (60064531)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KOGA Masataka (80136449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HIRAKATA Hideki (70181146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TOMITA Yukihiro (90180174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KURISU Kazuhiro (70294923)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  NISIMURA Yousuke (50301338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  原田 守 (50260716)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  吉村 昭彦 (90182815)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  箕口 滋 (60322757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  安藤 高志 (40281191)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  滝本 博明 (00253534)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  嘉手納 勉 (30325469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MAK Tak w
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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