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TOMA Hiroki  当間 宏樹

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… Alternative Names

当間 宏樹  トウマ ヒロキ

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Researcher Number 80437780
Affiliation (Current) 2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help 2025: 九州大学, 医学研究院, 共同研究員
2022 – 2023: 九州大学, 医学研究院, 共同研究員
2015 – 2018: 九州大学, 医学研究院, 共同研究員
2012 – 2015: 九州大学, 医学(系)研究科(研究院), 共同研究員
2012: 九州大学, 医学研究院, 共同研究員
2011: 九州大学, 大学病院, 講師
2007 – 2010: 九州大学, 大学病院, 助教
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Digestive surgery / Tumor biology and related fields
Keywords
Principal Investigator
膵癌 / miRNA / microRNA / 腫瘍免疫療法 / Autophagy抑制 / 膵癌微小環境 / 膵癌間質 / 樹状細胞 / 腫瘍免疫微小環境 / 腫瘍免疫 … More / CAF / Autophagy / 膵周囲脂肪組織 / S100A4 / リノレン酸 / 脂肪酸 / High fat diet / 活性化型膵星細胞 / 癌関連線維芽細胞 / 脂肪組織由来幹細胞 / エクソソーム / 癌間質相互作用 / マイクロダイセクション / Gemcitabine / 膵液 / 治療抵抗性 / 膵臓外科学 … More
Except Principal Investigator
膵癌 / 膵星細胞 / 癌間質相互作用 / IPMN / 膵臓外科学 / 膵臓癌 / オートファジー / microRNA / mRNA / 基質リモデリング制御 / 膵癌微小環境 / 3Dバイオプリンター / 癌関連線維芽細胞 / 微小環境 / オルガノイド / 3Dバイオプリンター / オートファジー抑制剤 / 創薬 / 早期診断 / 膵前癌病変 / 膵液 / miRNA / エクソゾーム / バイオマーカー / biomarker / micro RNA / exosome / ADM / PDAC / CD51 / 細胞外基質 / 腫瘍血管 / 血管リモデリング / 周皮細胞 / 抗繊維化薬 / ナノカプセル / 化学療法抵抗性 / ドラッグデリバリーシステム(DDS) / 抗間質薬 / 膵癌間質細胞 / 癌微小環境 / セルソーテング / 上皮間葉移行(EMT) / セルソーティング / mRNA/microRNA / 癌間相互作用 / 間質細胞 / ニッチ / 間質幹細胞 / 治療抵抗性 / セルソート / 癌幹細胞 / S100A11 / S100P / H-tert / Muc family / twist / FFPEサンプル / hTERT / テロメラーゼ / 電気化学チップ / LM04 / S100 family Less
  • Research Projects

    (16 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (21 People)
  •  エピゲノム解析による樹状細胞のラクチル化が抗原提示機能に及ぼす影響の検討Principal Investigator

    • Principal Investigator
      当間 宏樹
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kyushu University
  •  Autophagyに着目した、膵癌における免疫抑制微小環境の解明と新規治療開発Principal Investigator

    • Principal Investigator
      当間 宏樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter

    • Principal Investigator
      NAKAMURA Masafumi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Tumor biology and related fields
    • Research Institution
      Kyushu University
  •  Development of biomarkers target on exosomes which derived from stromal cells in premalignant microenvironment.

    • Principal Investigator
      MIYASAKA Yoshihiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  New drug discovery screening targeting autophagy

    • Principal Investigator
      NAKATA Kohei
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Role of adipose tissue in pancreatic cancer local invasion as a component of tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      TOMA Hiroki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Refractory cancer therapy development by cancer microenvironment elucidation and new drug delivery system based on autophagy

    • Principal Investigator
      NAGAI Eishi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Investigation of mechanisms about therapeutic resistance due to the difference of pancreatic stellate cell phenotypes and development of nano capsule including anti-stromal drugs

    • Principal Investigator
      MAEYAMA Ryo
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  A new strategy in the treatment of pancreatic cancer focused on the tumor vessel remodeling by pericytes

    • Principal Investigator
      MANABE Tatsuya
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  New development in the study of tumor-stromal interaction focused on extracellular miRNA via exosome.Principal Investigator

    • Principal Investigator
      TOMA Hiroki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer

    • Principal Investigator
      NAGAI Eishi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  General overview of research on diagnosis of pancreatic cancer using molecular makersinpancreaticjuiccandclinicalapPlicationofmolecularmakersondiagnosisofIPMNsubtype

    • Principal Investigator
      MIZUMOTO Kazihiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Prospective isolation of pancreatic cancer cells with highly malignant phenotype and development of future individualized therapy

    • Principal Investigator
      TANAKA Masao
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Identification of microRNA which is related to chemoresistance of pancreatic cancer, and intensification of the sensitivity by controlling the microRNA.Principal Investigator

    • Principal Investigator
      TOMA Hiroki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  膵癌幹細胞の同定とニッチの機能解析〜膵癌の治療抵抗性を克服するために

    • Principal Investigator
      水元 一博
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Gene expressions in microdissected target cells as the diagnostic markers of pancreatic cancer and the prediction of treatment outcome using nano-technology

    • Principal Investigator
      MIZUMOTO Kazuhiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University

All 2013 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers2013

    • Author(s)
      Nagai E, Ohuchida K, Nakata K, Toma H, Tanaka M
    • Journal Title

      Surgery

      Volume: 153(5) Pages: 732-8

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Feasibility of laparoscopic gastrectomy for advanced gastric cancer with positive peritoneal cytology2012

    • Author(s)
      Yamanaka N, Nagai E, Ohuchida K, Ueda J, Toma H, Tanaka M
    • Journal Title

      Surg Today

    • NAID

      10031189764

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma2012

    • Author(s)
      Nakata K, Nagai E, Ohuchida K, Ohtsuka T, Toma H, Tanaka M
    • Journal Title

      Hepatogastroenterology

      Volume: 59(118) Pages: 1855-8

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Single-incision laparoscopy -assisted surgery for bowel obstruction: report of three cases2011

    • Author(s)
      Ohtsuka T, Nagai E, Toma H, Ohuchida K, Tanaka M
    • Journal Title

      Surg Today

      Volume: 41(11) Pages: 1519-23

    • NAID

      10030229390

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer2011

    • Author(s)
      Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
    • Journal Title

      Ann Surg Oncol

      Volume: 18(7) Pages: 2057-65

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells2010

    • Author(s)
      Onimaru M, Ohuchida K, Egami T,Mizumoto K, Nagai E, Toma H, Tanaka M
    • Journal Title

      Cancer Gene Ther

      Volume: 17(8) Pages: 541-9

    • Data Source
      KAKENHI-PROJECT-22390258
  • [Journal Article] MircoRNA-2l modulates biological functions of pancreatic cacner cells including their proliferation, invasion and chemoresistance2009

    • Author(s)
      Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sate N, Nabae T, Takahata S, Toma H, Nagai E and Tanaka M
    • Journal Title

      Molecular cancer therapeutics

      Volume: 8 Pages: 1067-1074

    • Data Source
      KAKENHI-PROJECT-21390380
  • [Presentation] 膵癌におけるCD133陽性細胞は、癌間質作用を介してより高い遊走・浸潤能を獲得する.2009

    • Author(s)
      森山大樹, 大内田研宙, 水元一博, 崔林, 余俊, 江上拓哉, 藤田逸人, 佐藤典宏, 当間宏樹, 永井英司, 田中雅夫
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21390381
  • 1.  OHUCHIDA Kenoki (20452708)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 8 results
  • 2.  MIZUMOTO Kazuhiro (90253418)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 3 results
  • 3.  TOMINAGA Yohei (90304823)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  TANAKA Masao (30163570)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 7 results
  • 5.  EISHI Nagai (30264021)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 6.  UEDA Junji (90529801)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 7.  MIYASAKA Yoshihiro (40507795)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  MAEYAMA Ryo (10611668)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  SATO Norihro (20423527)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  EGAMI Takuya (40507787)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 11.  NAKATA Kohei (30419569)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  白羽根 健吾 (10529803)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  森山 大樹 (70586859)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  TKENAKA Shigeori (60188208)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  ONA Toshihiro (10346835)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MANABE Tatsuya (60546464)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  NAKAMURA Masafumi (30372741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  高畑 俊一 (50437779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  中山 功一 (50420609)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  佐田 政史 (10783508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  阿部 俊也 (20722028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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