Yamanaka Koji 山中宏二

… Alternative Names

YAMANAKA Koji 山中宏二

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Researcher Number	80446533
Other IDs	https://orcid.org/0000-0003-4655-0035
Affiliation (Current)	2025: 名古屋大学, 環境医学研究所, 教授
Affiliation (based on the past Project Information) *help	2013 – 2024: 名古屋大学, 環境医学研究所, 教授 2011 – 2012: 独立行政法人理化学研究所, その他部局等, 研究員 2009 – 2012: The Institute of Physical and Chemical Research, 運動ニューロン変性研究チーム, チームリーダー 2007 – 2008: The Institute of Physical and Chemical Research, 山中研究ユニット, ユニットリーダー 2007: The Institute of Physical and Chemical Research, 山中研究ユニット, ユニットリーダー
Review Section/Research Field	Principal Investigator Biological Sciences / Neurology / Medium-sized Section 52:General internal medicine and related fields / Biological Sciences / Basic Section 52020:Neurology-related Except Principal Investigator Nerve anatomy/Neuropathology / Bioorganic chemistry / Pathological medical chemistry / Complex Systems Disease Theory / Pharmacology in pharmacy / Neurology / Biological Sciences
Keywords	Principal Investigator 神経変性疾患 / 筋萎縮性側索硬化症 / グリア / 神経炎症 / ミクログリア / 神経病態生化学 / ALS / TDP-43 / 構造生物学 / モデルマウス … More / TBK1 / モデル動物 / 小胞体 / ミトコンドリア / オルガネラ / オルガネラゾーン / 免疫連関 / アストロサイト / 細胞外環境 / 脊髄 / 脊髄環境 / 環境 / グリア細胞 / タンパク質分解 … More Except Principal Investigator 筋萎縮性側索硬化症 / ミクログリア / 運動ニューロン / グリア / アストロサイト / 遺伝子 / RNA代謝 / RNA代謝異常 / 脊髄性筋萎縮症 / スプライシング / SMN / FUS / TDP-43 / スプライソソーム / SMA / ALS / 分子酸化 / プロオキシダント性 / 抗酸化 / protein stability / G6PDH / superoxide dismutase / hydroxyl radical / copper-induced oxidation / prooxidant / antioxidant / 蛋白質変性 / スーパーオキシドディスムターゼ 1 / ヒドロキシルラジカル / 銅イオン還元能 / プロオキシダント能 / 抗酸化能 / σ1受容体 / SOD1 / 小胞体・ミトコンドリア膜間領域 / レプチン / 視床下部 / 非アルコール性脂肪肝炎 / MC4R / 線維化 / 慢性炎症 / マクロファージ / NASH / 神経変性 / 選択的脆弱性 / 細胞外マトリクス / オステオポンチン / 神経変性疾患 / 自然免疫 / トランスクリプトーム / マイクロアレイ / 解剖学 / 蛋白質 / 改造学 / 神経科学 / 脳神経疾患 Less

TDP-43病理形成・分解機序に着目した筋萎縮性側索硬化症の分子病態解明と制御Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Identifying mechanisms of motor neuron degeneration through ER-mitochondria interactionPrincipal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Nagoya University
Elucidating molecular pathology of ALS through TBK1 gene networkPrincipal Investigator
- Principal Investigator
  
  Yamanaka Koji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
グリア・末梢免疫連関の制御を通じた神経変性機序の解明と治療標的同定Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Role of the crosstalk between liver and brain in the pathophysiology of liver fibrosis
- Principal Investigator
  
  Suganami Takayoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Nagoya University
Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.
- Principal Investigator
  
  KUROKAWA Yoichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Fukui Prefectural University
Elucidating pathomechanism of ALS through the abnormality in astrocytesPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Cell-autonomous and non-cell-autonomous mechanisms of neurodegeneration in ALS
- Principal Investigator
  
  Misawa Hidemi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Keio University
Disruption of mitochondria-associated membrane in neurodegenerative disease
- Principal Investigator
  
  Watanabe Seiji
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Common defects of RNA metabolism in motor neuron diseases SMA and ALS
- Principal Investigator
  
  Tsuiji Hitomi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagoya City University
  Institute of Physical and Chemical Research
Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome
- Principal Investigator
  
  YAMASHITA Hirofumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
神経-グリアネットワーク変調が来す運動神経変性機序の解明Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Brain Environment
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interactionPrincipal Investigator
- Principal Investigator
  
  Yamanaka Koji
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  The Institute of Physical and Chemical Research
Elucidating molecular pathology of glial cells in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
神経炎症の制御を標的とした筋萎縮性側索硬化症の治療法の開発Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
神経変性疾患における病因遺伝子産物のユビキチン修飾と分解機構の解明Principal Investigator
- Principal Investigator
  
  山中宏二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
A role of microglia in Amyotrophic Lateral SclerosisPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 遺伝子医学MOOK26 脳内環境ー維持機構と破綻がもたらす疾患研究2014
- Author(s)
  小峯起、山中宏二
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26293208
[Book] Animal Biotechnology2014
- Author(s)
  Hitomi Tsuiji and Koji Yamanaka
- Total Pages
  18
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-25430055
[Book] Animal Biotechnology: Models in Discovery and Translation2013
- Author(s)
  Tsuiji Hitomi, Yamanaka Koji
- Publisher
  Elsevier
- Data Source
  KAKENHI-PLANNED-23111006
[Book] 実験医学別冊「臓器円環による生体恒常性のダイナミクス」2013
- Author(s)
  山中宏二
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-23111006
[Book] すべてがわかるALS・運動ニューロン疾患2013
- Author(s)
  山中宏二、小峯起
- Publisher
  中山書店
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice.2024
- Author(s)
  Komine O., Ohnuma S., Hinohara K., Hara Y., Shimada M., Akashi T., Watanabe S., Sobue A., Kawade N., Ogi T., Yamanaka K..
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 2 Pages: 108872-108872
- DOI
  10.1016/j.isci.2024.108872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13902, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-21K20569, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23H00516
[Journal Article] Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis2023
- Author(s)
  Watanabe Seiji、Horiuchi Mai、Murata Yuri、Komine Okiru、Kawade Noe、Sobue Akira、Yamanaka Koji
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 179 Pages: 106031-106031
- DOI
  10.1016/j.nbd.2023.106031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-21K20569, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22H00467
[Journal Article] Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease2023
- Author(s)
  Yamashita Hirofumi、Komine Okiru、Fujimori-Tonou Noriko、Yamanaka Koji
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 16 Pages: 1045647-1045647
- DOI
  10.3389/fncel.2022.1045647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-22H00467
[Journal Article] Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation2023
- Author(s)
  Hashimoto Kei、Watanabe Seiji、Akutsu Masato、Muraki Norifumi、Kamishina Hiroaki、Furukawa Yoshiaki、Yamanaka Koji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104798-104798
- DOI
  10.1016/j.jbc.2023.104798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K05670, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22KJ1574, KAKENHI-PLANNED-19H05765, KAKENHI-PROJECT-23K24031, KAKENHI-PROJECT-22H00467
[Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023
- Author(s)
  Oiwa Kotaro、Watanabe Seiji、Onodera Kazunari、Iguchi Yohei、Kinoshita Yukako、Komine Okiru、Sobue Akira、Okada Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 31
- DOI
  10.1126/sciadv.adf6895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-22H00467, KAKENHI-PROJECT-23K24249
[Journal Article] Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS2023
- Author(s)
  Watanabe Seiji、Murata Yuri、Oka Yasuyoshi、Oiwa Kotaro、Horiuchi Mai、Iguchi Yohei、Komine Okiru、Sobue Akira、Katsuno Masahisa、Ogi Tomoo、Yamanaka Koji
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 47
- DOI
  10.1073/pnas.2315347120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-22H00467
[Journal Article] Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis2021
- Author(s)
  Sakai Shohei、Watanabe Seiji、Komine Okiru、Sobue Akira、Yamanaka Koji
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 7
- DOI
  10.1096/fj.202100137r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-ORGANIZER-17H06413
[Journal Article] Aggresome formation and liquid?liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 432020
- Author(s)
  Watanabe Seiji、Inami Hidekazu、Oiwa Kotaro、Murata Yuri、Sakai Shohei、Komine Okiru、Sobue Akira、Iguchi Yohei、Katsuno Masahisa、Yamanaka Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 10 Pages: 909-909
- DOI
  10.1038/s41419-020-03116-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-20H03589, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis2020
- Author(s)
  Amporndanai Kangsa、Rogers Michael、Watanabe Seiji、Yamanaka Koji、O'Neill Paul M.、Hasnain S. Samar
- Journal Title
  
  EBioMedicine
  
  Volume: 59 Pages: 102980-102980
- DOI
  10.1016/j.ebiom.2020.102980
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration2020
- Author(s)
  Watanabe Seiji、Oiwa Kotaro、Murata Yuri、Komine Okiru、Sobue Akira、Endo Fumito、Takahashi Eiki、Yamanaka Koji
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 8-8
- DOI
  10.1186/s13041-020-0550-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0214, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-19K21221
[Journal Article] Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1?Akt signaling pathway2019
- Author(s)
  Nishino Kohei、Watanabe Seiji、Shijie Jin、Murata Yuri、Oiwa Kotaro、Komine Okiru、Endo Fumito、Tsuiji Hitomi、Abe Manabu、Sakimura Kenji、Mishra Amit、Yamanaka Koji
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 7 Issue: 1 Pages: 118-118
- DOI
  10.1186/s40478-019-0776-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01972, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986
[Journal Article] 筋萎縮性側索硬化症におけるMAMの破綻.2019
- Author(s)
  渡邊征爾，山中宏二
- Journal Title
  
  実験医学増刊ミトコンドリアと疾患・老化
  
  Volume: 37 Pages: 138-144
- Data Source
  KAKENHI-PUBLICLY-18H04860
[Journal Article] The multi-dimensional roles of astrocytes in ALS2018
- Author(s)
  Yamanaka Koji、Komine Okiru
- Journal Title
  
  Neuroscience Research
  
  Volume: 126 Pages: 31-38
- DOI
  10.1016/j.neures.2017.09.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K14963, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336
[Journal Article] Phenotypic heterogeneity of astrocytes in motor neuron disease.2018
- Author(s)
  Trias E, Barbeito L, Yamanaka K
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 9 Issue: 4 Pages: 225-234
- DOI
  10.1111/cen3.12476
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02740
[Journal Article] A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis2018
- Author(s)
  Tokuda Eiichi、Nomura Takao、Ohara Shinji、Watanabe Seiji、Yamanaka Koji、Morisaki Yuta、Misawa Hidemi、Furukawa Yoshiaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Basis of Disease
  
  Volume: 印刷中 Issue: 6 Pages: 2119-2130
- DOI
  10.1016/j.bbadis.2018.03.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05705, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K16634, KAKENHI-PROJECT-18K05329, KAKENHI-PUBLICLY-18H04860, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K15077
[Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes2018
- Author(s)
  Komine Okiru、Yamashita Hirofumi、Fujimori-Tonou Noriko、Koike Masato、Jin Shijie、Moriwaki Yasuhiro、Endo Fumito、Watanabe Seiji、Uematsu Satoshi、Akira Shizuo、Uchiyama Yasuo、Takahashi Ryosuke、Misawa Hidemi、Yamanaka Koji
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 印刷中 Issue: 12 Pages: 2130-2146
- DOI
  10.1038/s41418-018-0098-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K14963
[Journal Article] Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis2017
- Author(s)
  Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, and Yoshiaki Furukawa
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 12 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13024-016-0145-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01566, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K14480, KAKENHI-PROJECT-25860252
[Journal Article] Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9.2016
- Author(s)
  Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, *Misawa H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 27354-27354
- DOI
  10.1038/srep27354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K21370, KAKENHI-PROJECT-16H06277
[Journal Article] Neuroinflammation in motor neuron disease.2016
- Author(s)
  Endo F, Komine O, Yamanaka K.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Issue: 2 Pages: 126-138
- DOI
  10.1111/cen3.12309
- NAID
  120005672307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-16K09671
[Journal Article] Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 4 Issue: 1 Pages: 15-15
- DOI
  10.1186/s40478-016-0286-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-26293208
[Journal Article] Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.2016
- Author(s)
  Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 8 Issue: 12 Pages: 1421-1437
- DOI
  10.15252/emmm.201606403
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-16H05117, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K19321, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PROJECT-16K09671
[Journal Article] Neuroinflammation in motor neuron disease.2015
- Author(s)
  Komine O, Yamanaka K
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 77 Pages: 537-549
- NAID
  120005672307
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells.2015
- Author(s)
  Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 4 Pages: 592-604
- DOI
  10.1016/j.celrep.2015.03.053
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26293208, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
[Journal Article] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model.2015
- Author(s)
  Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 86 Pages: 16-16
- DOI
  10.1016/j.nbd.2015.11.017
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-26293208
[Journal Article] Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity.2014
- Author(s)
  WATANABE Seiji, HAYAKAWA Tomoyo, Wakasugi Keisuke, YAMANAKA Koji
- Journal Title
  
  Cell Death & Disease
  
  Volume: 5 Issue: 10 Pages: e1497-e1497
- DOI
  10.1038/cddis.2014.459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440047
[Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.2014
- Author(s)
  Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
- Journal Title
  
  Mol Brain
  
  Volume: 7 Issue: 1 Pages: 62-62
- DOI
  10.1186/s13041-014-0062-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078
[Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014
- Author(s)
  Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 2 Pages: 1192-1202
- DOI
  10.1074/jbc.m113.516492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.2014
- Author(s)
  AUSTIN James J., WRIGHT Gareth S., WATANABE Seiji, GROSSMANN Gunter, ANTONYUK Svetlana V., YAMANAKA Koji, HASNAIN S. Samar
- Journal Title
  
  Proceedings of the National Academy of Sciences of U.S.A.
  
  Volume: 111 Issue: 11 Pages: 4309-4314
- DOI
  10.1073/pnas.1317317111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25860252
[Journal Article] Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis2013
- Author(s)
  Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 16 Pages: 2500-2505
- DOI
  10.1016/j.febslet.2013.06.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-24111542, KAKENHI-PROJECT-24657093, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25291028
[Journal Article] Loss of TDP-43 causes age-dependent progressive motor neuron degeneration2013
- Author(s)
  Iguchi Y
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 5 Pages: 1371-1382
- DOI
  10.1093/brain/awt029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22390175, KAKENHI-PROJECT-22590965, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659452, KAKENHI-PROJECT-25293020, KAKENHI-PLANNED-22110005
[Journal Article] E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity.2013
- Author(s)
  MISHRA Amit, MAHESHIWARI Megha, CHHANGANI Deepak, FUJIMORI-TONOU Noriko, ENDO Fumito, JOSHI A.Prakashi, JANA N.Ranjan, YAMANAKA Koji
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 34 Issue: 4 Pages: 1310.e11-1310.e23
- DOI
  10.1016/j.neurobiolaging.2012.08.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
- Author(s)
  Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
- Journal Title
  
  Cell Stem Cell
  
  Volume: 12 Issue: 4 Pages: 487-496
- DOI
  10.1016/j.stem.2013.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21248015, KAKENHI-PLANNED-22129006, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23592093, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24590040, KAKENHI-PROJECT-24700367, KAKENHI-PROJECT-24790260, KAKENHI-PROJECT-24790276, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25290018, KAKENHI-PROJECT-25460341, KAKENHI-PUBLICLY-23110535, KAKENHI-PUBLICLY-23123510
[Journal Article] ALS病態におけるグリアの役割2012
- Author(s)
  山下博史,山中宏二
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 28-33
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] ALS病態におけるグリアの役割2012
- Author(s)
  山下博史、山中宏二
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 28-33
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] ALS-SOD1の発症機序2011
- Author(s)
  山下博史,山中宏二
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 1044-1045
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Glial cells in Amyotrophic Lateral Sclerosis2011
- Author(s)
  Lasiene, J., Yamanaka, K.
- Journal Title
  
  Neurol.Res.Int.
  
  Volume: 2011 Pages: 718987-718987
- DOI
  10.1155/2011/718987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00518, KAKENHI-PUBLICLY-23110523
[Journal Article] Glial cells i n Amyotrophic Lateral Sclerosis2011
- Author(s)
  Takeuchi H., 他14名, Yamanaka K., S obue G., Mizuno T, Suzumura A
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Glial cells i n Amyotrophic Lateral Sclerosis2011
- Author(s)
  Lasiene J., Yamanaka K
- Journal Title
  
  Neurol Res Int 2011
  
  Pages: 718987-718987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Mutation-dependent poly morphism of Cu, Zn-superoxide dismuta se aggregates in the familial form of am yotrophic lateral sclerosis2010
- Author(s)
  Furukawa Y., Kaneko K., Yamanaka K., Nukina N.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 22221-22231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] 神経変性疾患における細胞死研究のパラダイムシフト2010
- Author(s)
  山中宏二
- Journal Title
  
  実験医学増刊
  
  Volume: 28 Pages: 1188-1194
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Misf olded Mutant SOD1 Directly Inhibits V DAC1 Conductance in a Mouse Model of Inherited ALS2010
- Author(s)
  Israelson A., 他4名, Yamanaka K., S hoshan-Barmatz V., Cleveland D. W.
- Journal Title
  
  Neuron
  
  Volume: 67 Pages: 575-587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] ALSの病態-非細胞自律性の神経細胞死2010
- Author(s)
  山中宏二,遠藤史人
- Journal Title
  
  医学のあゆみ
  
  Volume: 235 Pages: 241-245
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice2009
- Author(s)
  Lobsiger C. S., 他4名, Yamanaka K., Cleveland D. W.
- Journal Title
  
  Natl. Acad. Sci
  
  Volume: 106 Pages: 4465-4470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] ALSの今後の研究方向と可能性は2009
- Author(s)
  山中宏二
- Journal Title
  
  MB Medical Rehabilitation
  
  Volume: 113 Pages: 13-18
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] 筋萎縮性側索硬化症とグリア細胞2009
- Author(s)
  山中宏二
- Journal Title
  
  Medical Science Digest
  
  Volume: 35 Pages: 262-263
- Data Source
  KAKENHI-PROJECT-21390274
[Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.2008
- Author(s)
  Koji Yamanaka, et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 7594-7599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044048
[Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice2008
- Author(s)
  Yamanaka K, Boillee S, Roberts EA, et al.(8名中1番目)
- Journal Title
  
  Proc. Natl. Acad. Sci., USA, 105
  
  Pages: 7594-7599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008
- Author(s)
  Koji Yamanaka, et. al.
- Journal Title
  
  Nature Neuroscience (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.2008
- Author(s)
  Koji Yamanaka, et. al.
- Journal Title
  
  Nature Neuroscience (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044048
[Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice2008
- Author(s)
  Koji Yamanaka, et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 7594-7599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death2008
- Author(s)
  Ilieva H, Yamanaka K, Malkmus S, et al.(7名中2番目)
- Journal Title
  
  Proc. Natl. Acad. Sci., USA. 105
  
  Pages: 12599-12604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis2008
- Author(s)
  Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Misawa H, Takahashi R, & Cleveland DW.
- Journal Title
  
  Nat. Neurosci. 11
  
  Pages: 251-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.2008
- Author(s)
  Koji Yamanaka, et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 7594-7599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023034
[Journal Article] ALSとミクログリア: 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二、山下博史
- Journal Title
  
  Brain and Nerve 59
  
  Pages: 1163-1170
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] ALSとミクログリア:非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二
- Journal Title
  
  Brain and Nerve 59
  
  Pages: 1163-1170
- Data Source
  KAKENHI-PROJECT-19591021
[Journal Article] ALSとミクログリア: 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二
- Journal Title
  
  Brain and Nerve 59
  
  Pages: 1163-1170
- Data Source
  KAKENHI-PROJECT-19044048
[Presentation] Molecular Basis of TDP-43 pathology in neurodegenerative disease.2023
- Author(s)
  Oiwa K , Yamanaka K
- Organizer
  Japan-UK Neuroscience symposium.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] ALSにおけるTDP-43病理形成の分子基盤.2023
- Author(s)
  山中宏二
- Organizer
  第64回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Molecular Basis of TDP-43 pathology in neurodegenerative disease.2023
- Author(s)
  Oiwa K , Yamanaka K
- Organizer
  Japan-UK Neuroscience symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] 筋萎縮性側索硬化症におけるTDP-43病理形成の分子基盤と疾患修飾療法への展望.2023
- Author(s)
  山中宏二.
- Organizer
  第42回日本認知症学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Sigma 1 receptor, an ALS16-causative gene product, prevents mitochondrial fragmentation via ATAD3A in ALS.2023
- Author(s)
  Watanabe S, Horiuchi M, Yamanaka K.
- Organizer
  34th International Symposium on ALS/MND.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] 筋萎縮性側索硬化症におけるTDP-43病理形成の分子基盤と疾患修飾療法への展望2023
- Author(s)
  山中宏二
- Organizer
  第42回日本認知症学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] ALSにおけるTDP-43病理形成の分子基盤2023
- Author(s)
  山中宏二
- Organizer
  第64回日本神経学会学術大会シンポジウム講演
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] タンパク質ストレス応答における小胞体・ミトコンドリア接触部の新たな役割.2023
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第64回日本神経病理学会総会学術研究会第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] 認知症・神経変性疾患におけるミクログリアの分子病態.2022
- Author(s)
  山中宏二.
- Organizer
  第43回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] 神経変性疾患における蛋白質品質管理異常.2022
- Author(s)
  山中宏二.
- Organizer
  第22回日本抗加齢医学会総会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] 神経変性疾患における蛋白質品質管理異常.2022
- Author(s)
  山中宏二
- Organizer
  第22回日本抗加齢医学会総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS.2022
- Author(s)
  大岩康太郎、渡邊征爾、小野寺一成、井口洋平、岡田洋平、勝野雅央、山中宏二
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] ALSにおけるTDP-43の凝集・局在異常の分子機構.2022
- Author(s)
  山中宏二
- Organizer
  第95回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] 生命金属タンパク質異常による神経変性疾患の病態とその制御.2022
- Author(s)
  山中宏二
- Organizer
  第１回生命金属科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] TDP-43異常に基づいたALS/FTDマウスモデル：最近の知見.2022
- Author(s)
  山中宏二
- Organizer
  第63回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] 神経変性疾患における蛋白質品質管理異常2022
- Author(s)
  4.山中宏二
- Organizer
  第22回日本抗加齢医学会総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] ALSにおけるTDP-43の凝集・局在異常の分子機構2022
- Author(s)
  山中宏二
- Organizer
  第95回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] The role of neuroinflammation in neurodegenerative diseases and Alzheimer's disease.2022
- Author(s)
  山中宏二.
- Organizer
  第34回日本神経免疫学会学術集会, JSNI-PNIRS Asia-Pacific Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] TDP-43異常に基づいたALS/FTDマウスモデル：最近の知見.2022
- Author(s)
  山中宏二
- Organizer
  第63回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] TANK結合キナーゼ1（TBK1）は小胞体・ミトコンドリア接触領域において細胞のタンパク質恒常性ストレス応答を促進する.2022
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第95回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00467
[Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS.2021
- Author(s)
  大岩康太郎、渡邊征爾、井口洋平、勝野雅央、山中宏二.
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Mechanism for inducing TDP-43 pathology in ALS.2021
- Author(s)
  Koji Yamanaka
- Organizer
  PACTALS (Pan-Asia Consortium for Treatment and Research in ALS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] E40K変異イヌSOD1タンパク質の種特異的凝集に重要なアミノ酸残基の同定.2021
- Author(s)
  橋本　慶、渡邊征爾、小峯起、祖父江顕、神志那弘明、山中宏二.
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] 単量体・多量体バランスの異常はALSにおけるTDP-43病理を形成する.2021
- Author(s)
  山中宏二
- Organizer
  第62回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] グリア－免疫連関からみた神経変性疾患.2020
- Author(s)
  山中宏二
- Organizer
  第63回日本神経化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] 運動神経変性における小胞体・ミトコンドリア連関の破綻.2020
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第93回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] Multimerization of TDP-43 plays a key role in determination of its subcellular localization.2020
- Author(s)
  大岩康太郎、渡邊征爾、祖父江　顕、小峯　起、勝野雅央、山中宏二.
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] The role of neuroinflammation in neurodegenerative diseases.2020
- Author(s)
  Yamanaka K.
- Organizer
  The 15th International Symposium on Geriatrics and Gerontology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] Glia-immune communication in ALS.2020
- Author(s)
  山中宏二
- Organizer
  第61回日本神経学会学術大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] Molecular pathomechanism of motor neuron disease.2020
- Author(s)
  Yamanaka K
- Organizer
  UK-Japan Neuroscience Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] Collapse of Mitochondria-associated membrane as common pathomechanism in familial ALS including SOD1 mutations.2019
- Author(s)
  Yamanaka Koji.
- Organizer
  Mini-Symposium "Metal in ALS"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04860
[Presentation] TDP-43 mutant lacking its C-terminal domain induces age-dependent motor dysfunction in mice.2019
- Author(s)
  Watanabe S, Nishino K, Murata Y, Oiwa K, Yamanaka K.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0214
[Presentation] 神経変性疾患の治療標的としてのグリア細胞 (Overview: glia as therapeutic targets for neurodegenerative diseases.)2019
- Author(s)
  山中宏二
- Organizer
  第60回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] 運動神経変性におけるオルガネラ連携の破綻2019
- Author(s)
  山中宏二
- Organizer
  第42回日本神経科学大会第62回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04860
[Presentation] Identification of MAM disruption as a general pathological mechanism in ALS.2018
- Author(s)
  渡邊征爾, 山中宏二
- Organizer
  第40回日本生物学的精神医学会第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PUBLICLY-18H04860
[Presentation] 筋萎縮性側索硬化症における免疫・グリア連関2018
- Author(s)
  山中宏二
- Organizer
  第40回日本生物学的精神医学会第61回日本神経化学会大会合同年会シンポジウム.
- Invited
- Data Source
  KAKENHI-PROJECT-18H02740
[Presentation] 運動ニューロン疾患における小胞体・ミトコンドリア膜間領域破綻の意義．2018
- Author(s)
  山中宏二
- Organizer
  第59回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04860
[Presentation] 筋萎縮性側索硬化症におけるグリア細胞・神経炎症の役割2017
- Author(s)
  山中宏二
- Organizer
  千里ライフサイエンスセミナー,　神経変性疾患の最前線
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] 運動神経変性におけるグリア細胞・神経炎症の役割2017
- Author(s)
  山中宏二
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 運動神経変性におけるグリア細胞・神経炎症の役割2017
- Author(s)
  山中宏二
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)ワークショップ
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017
- Author(s)
  Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
- Organizer
  28th International symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] ALSにおける細胞群特異性病態と治療への展開2017
- Author(s)
  山中宏二
- Organizer
  第39回日本生物学的精神医学会, 第47回日本神経精神薬理学会合同年会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017
- Author(s)
  Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
- Organizer
  28th International symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] ALSにおける細胞群特異性病態と治療への展開2017
- Author(s)
  山中宏二
- Organizer
  第39回日本生物学的精神医学会, 第47回日本神経精神薬理学会合同年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 筋萎縮性側索硬化症におけるグリア細胞・神経炎症の役割2017
- Author(s)
  山中宏二
- Organizer
  千里ライフサイエンスセミナー,神経変性疾患の最前線（グリア細胞と神経疾患）
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 免疫学的視点からみた神経変性疾患の分子病態.2017
- Author(s)
  山中宏二
- Organizer
  第29回日本神経免疫学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS.2017
- Author(s)
  Endo F, Yamanaka K
- Organizer
  28th international Symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 免疫学的視点からみた神経変性疾患の分子病態2017
- Author(s)
  山中宏二
- Organizer
  第29回日本神経免疫学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016
- Author(s)
  Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
- Organizer
  The 21st Annual Meeting of the RNA Society
- Place of Presentation
  京都国際会館
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] ALS病態における末梢免疫の役割2016
- Author(s)
  大沼周平、小峯　起、山中宏二
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Active role of neuroinflammation in motor neuron disease2016
- Author(s)
  Yamanaka Koji
- Organizer
  The 2nd IMCR Symposium on Endocrine and Metabolism: International Frontiers in Homeostatic Regulation Research,
- Place of Presentation
  群馬
- Year and Date
  2016-11-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Disruption of Mitochondria-associated membrance is a common pathomechanism both in SOD1-and SIGMAR1-linked ALS.2016
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] グリア細胞からみた神経変性疾患2016
- Author(s)
  山中宏二
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Disruption of mitochondria associated membrane in amyotrophic lateral sclerosis.2016
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  第６回生理学研究所・名古屋大学医学系研究科合同シンポジウム
- Place of Presentation
  名古屋大学鶴舞キャンパス
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Dysregulation of neuronal TGF-β signaling contributes to neurodegeneration in mutant SOD1 mice.2016
- Author(s)
  遠藤史人、宮﨑　朗、山中宏二
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016
- Author(s)
  Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
- Organizer
  第39回　日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Active role of neuroinflammation in motor neuron disease.2016
- Author(s)
  Yamanaka Koji
- Organizer
  The 2nd IMCR Symposium on Endocrine and Metabolism: International Frontiers in Homeostatic Regulation Research,
- Place of Presentation
  群馬
- Year and Date
  2016-11-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] グリア細胞からみた神経変性疾患2016
- Author(s)
  山中宏二
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] ALSにおける運動神経サブタイプ選択的脆弱性を規定するメカニズム2016
- Author(s)
  森﨑祐太, 渡邉みずほ, 森脇康博, 山中宏二, 三澤日出巳
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川県・横浜市)
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] Dysregulation of TGF-β signaling facilitates motor neurodegeneration of ALS mice.2016
- Author(s)
  遠藤史人、山中宏二
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] ミクログリア・単球系細胞と神経変性疾患.2016
- Author(s)
  山中宏二
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] The role of peripheral immune system in amyotrophic lateral sclerosis mice2016
- Author(s)
  小峯起、大沼周平、池田早織、山中宏二.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PUBLICLY-16H01336
[Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2016
- Author(s)
  Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
- Organizer
  11th Brain Research Conference
- Place of Presentation
  Paradise Point, San Diego, CA
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] In vivo and in vitro characterization of SOD1 in early stages of ALS as a precursor to insoluble aggregates.2016
- Author(s)
  Tokuda E, Anzai I, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  アイルランド, ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by regulating the neuroprotective inflammatory response of microglia and T cells.2015
- Author(s)
  山中宏二、遠藤史人、小峯起、金世杰、渡邊征爾
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] アストロサイト由来TGF-β1はALSの疾患進行を規定する.2015
- Author(s)
  遠藤史人、小峯起、金世杰、渡邊征爾、山中宏二
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] The role of astrocyte-derived TGF-β in motor neuron disease.2015
- Author(s)
  Yamanaka Koji
- Organizer
  25th International Society for Neurochemistry Biennial Meeting, symposium
- Place of Presentation
  ケアンズ、豪州
- Year and Date
  2015-08-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Pathomechanisms and therapeutic directions common to motor neuron diseases.2015
- Author(s)
  山中　宏二
- Organizer
  第56回日本神経学会学術大会　シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] グリア細胞からみた運動神経変性機序2015
- Author(s)
  山中宏二
- Organizer
  第34回日本認知症学会学術集会　シンポジウム
- Place of Presentation
  青森
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 運動ニューロンサブタイプの選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015
- Author(s)
  森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター (兵庫県・神戸市)
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] Pathomechanisms and therapeutic directions common to motor neuron diseases.2015
- Author(s)
  山中宏二
- Organizer
  第56回日本神経学会学術大会シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 前頭側頭葉変性症モデルマウスの脳の組織学的な解析2015
- Author(s)
  竹内真理、山中宏二、築地仁美、服部光治
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部
- Place of Presentation
  名古屋（愛知県）
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] 筋萎縮性側索硬化症ALSを引き起こす変異型FUS/TLSの解析2015
- Author(s)
  近藤佑多、古屋亜佐子、内匠透、山中宏二、築地仁美、服部光治
- Organizer
  第61回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋（愛知県）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] The role of astrocyte-derived TGF-β in motor neuron disease.2015
- Author(s)
  Yamanaka Koji
- Organizer
  26th International Society for Neurochemistry Biennial Meeting
- Place of Presentation
  ケアンズ、豪州
- Year and Date
  2015-08-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Interneuron degeneration in TDP-43 transgenic mice displaying impaired memory2015
- Author(s)
  Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mitsuharu Hattori, Koji Yamanaka
- Organizer
  10th Brain Research Conference
- Place of Presentation
  シカゴ（アメリカ）
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Sigma 1 receptor deficiency is involved in motor neuronal degeneration through calcium deregulation at mitochondria-associated membrane.2015
- Author(s)
  渡邊征爾、山中宏二
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] The role of innate immune TRIF pathway in amyotrophic lateral sclerosis.2015
- Author(s)
  小峯起、山下博史、藤森典子、森脇康博、遠藤史人、渡邊征爾、金世杰、三澤日出巳、山中宏二
- Organizer
  第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム
- Place of Presentation
  生理学研究所
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015
- Author(s)
  小峯　起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] グリア細胞からみた運動神経変性機序2015
- Author(s)
  山中　宏二
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Roles of osteopontin and matrix metalloproteinase-9 in the subtype-selective motor neuron vulnerability in ALS2015
- Author(s)
  Morisaki Y, Tsubota A, Watanabe M, Moriwaki Y, Yamanaka K, Misawa H
- Organizer
  The 45th Annual Meeting, Society for Neuroscience
- Place of Presentation
  Chicago (USA)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] The active roles of glial cells in motor neuron disease.2015
- Author(s)
  Yamanaka Koji
- Organizer
  The10th Annual GEO-PD(Genetic Epidemiology of Parkinson’s Disease).
- Place of Presentation
  東京
- Year and Date
  2015-10-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] The active roles of glial cells in motor neuron disease.2015
- Author(s)
  Yamanaka Koji
- Organizer
  The10th Annual GEO-PD (Genetic Epidemiology of Parkinson’s Disease)
- Place of Presentation
  東京
- Year and Date
  2015-10-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 and is defective in ALS mice. 26th International Symposium on ALS/MLD2015
- Author(s)
  Chhangani D, Endo F, Amanullah A, Watanabe S, Mishra R, Mishra A, Yamanaka K
- Organizer
  26th International Symposium on ALS/MLD
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] Calcium deregulation atmitochondria-associated membrane is important for motor neuronal degeneration in amyotrophic lateral sclerosis.2015
- Author(s)
  Watanabe S, Yamanaka K
- Organizer
  BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] 運動ニューロンのサブタイプ選択的脆弱性におけるオステオポンチンとマトリックスメタロプロテアーゼ-9の役割2015
- Author(s)
  森崎祐太、坪田充司、森脇康博、山中宏二、三澤日出巳
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014
- Author(s)
  森﨑祐太、坪田充司、森脇康博、奥田隆志、山中宏二、三澤日出巳
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita 、 Noriko Fujimori 、 Hidefumi Ito 、Yohei Iguchi 、Naoki Atsuta 、 Fumiaki Tanaka 、Gen Sobue 、 Ryosuke Takahashi 、Koji Yamanaka
- Organizer
  Nucleic Acid Summit
- Place of Presentation
  San Diego,U.S.A.
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24591259
[Presentation] オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである2014
- Author(s)
  森﨑祐太、坪田充司、森脇康博、奥田隆志、山中宏二、三澤日出巳.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] 神経変性疾患ALSにおける自然免疫機構の役割.2014
- Author(s)
  山中宏二
- Organizer
  第37回日本神経科学大会シンポジウム
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 筋萎縮性側索硬化症における細胞群特異的病態の解明2014
- Author(s)
  山中宏二
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-05-23
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 筋萎縮性側索硬化症における細胞群特異的病態の解明2014
- Author(s)
  山中宏二
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 筋萎縮性側索硬化症における浸潤免疫細胞の機能解明2014
- Author(s)
  小峯起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] 筋萎縮性側索硬化症における神経炎症2014
- Author(s)
  遠藤史人、山中宏二
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] 筋萎縮性側索硬化症における神経炎症.2014
- Author(s)
  遠藤史人、山中宏二
- Organizer
  第55回日本神経学会学術大会シンポジウム
- Place of Presentation
  福岡国際会議場（福岡）
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita, Okiru komine, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] 筋萎縮性側索硬化症における運動ニューロン変性とオステオポンチンおよびマトリックスメタロプロテアーゼ-9の関連の検討2014
- Author(s)
  森﨑祐太、坪田充司、森脇康博、山中宏二、三澤日出巳.
- Organizer
  第131回日本薬理学会関東部会
- Place of Presentation
  横浜市
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome2014
- Author(s)
  Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka
- Organizer
  Nucleic Acid Summit
- Place of Presentation
  San Diego
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] Spliceosome integrity is defective in motor neuron disease ALS and SMA2013
- Author(s)
  Tsuiji H., Iguchi Y., Furuya A., Kataoka A., Hatsuta H., Atsuta N., Tanaka F.Hashizume Y., Akatsu H., Murayama S., Sobue G., Yamanaka K.
- Organizer
  第３６回日本神経科学大会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome.2013
- Author(s)
  Hirofumi Yamashita, Noriko Fujimori, Hidefumi Ito, Yohei Iguchi, Naoki Atsuta, Fumiaki Tanaka, Gen Sobue, Ryosuke Takahashi, Koji Yamanaka.
- Organizer
  Neuro2013
- Place of Presentation
  京都市
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] 中枢神経系に浸潤する免疫系細胞とグリア連関の神経変性病態への役割.2013
- Author(s)
  山中宏二
- Organizer
  第36 回日本神経科学大会
- Place of Presentation
  京都国際会議場（京都）
- Year and Date
  2013-06-20
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 変異スーパーオキシドジスムターゼ1（SOD1）はSOD1（G93A）マウスにおいてミトコンドリア・小胞体膜間領域に蓄積する2013
- Author(s)
  渡邊征爾, 山中宏二
- Organizer
  Neuro2013（第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会）
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] 神経変性疾患モデルであるTDP-43トランスジェニックマウスにおけるTDP-43標的遺伝子の同定2013
- Author(s)
  築地仁美、井上郁代、古屋亜佐子、山中宏二
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] The role of microglia-immune interaction in neurodegeneration of ALS mouse model.2013
- Author(s)
  Koji Yamanaka
- Organizer
  2013 conference of International Society for Neurochemistry
- Place of Presentation
  Cancun（メキシコ）
- Year and Date
  2013-04-22
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Glial cells in experimental models of ALS: from a view of glia-immune communication.2013
- Author(s)
  Koji Yamanaka
- Organizer
  3rd Venusberg meeting on Neuroinflammation
- Place of Presentation
  Bonn, Germany
- Year and Date
  2013-02-28
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Cell-type specific gene expression changes in TDP-43 transgenic mice displaying memory defect.2013
- Author(s)
  Tsuiji H., Inoue I., Kataoka A., Furuya A., Yamanaka K.
- Organizer
  RNA Biology in Neurological diseases
- Place of Presentation
  カリフォルニア、米国
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Spliceosome integrity is defective in motor neuron disease ALS and SMA.2013
- Author(s)
  Tsuiji H., Iguchi Y., Furuya A., Murayama S., Sobue G., Yamanaka K.
- Organizer
  RNA 2013 The 18th Annual Meeting of the RNA Society
- Place of Presentation
  Davos, Switzerland
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Cystatin C protected neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity in vitro.2013
- Author(s)
  Seiji Watanabe, Keisuke Wakasugi, Koji Yamanaka
- Organizer
  24th International Symposium on ALS/MND
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] The roles of microglia and immune system in neurodegeneration of ALS.2012
- Author(s)
  Koji Yamanaka
- Organizer
  Neuro2012
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2012-09-18
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Non-autonomous cell deathは、神経変性疾患の共通機構か？2012
- Author(s)
  山中宏二
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2012-05-23
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] The role of glia-immune communication in Amyotrophic Lateral Sclerosis.2012
- Author(s)
  Koji Yamanaka
- Organizer
  2012 The Korean Society for Neurodegenerative Disease Symposium
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] ALSにおけるグリア関連病態2011
- Author(s)
  山中宏二
- Organizer
  第52回日本神経学会学術大会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Recent advances in motor neuron disease : from modeling disease in laboratory animals to understanding human neurodegenerative disease2011
- Author(s)
  Yamanaka K.
- Organizer
  2011 KALAS (Korea Association for Laboratory Animal Science) International Symposium
- Place of Presentation
  Muju, Korea(招待講演)
- Year and Date
  2011-08-25
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] The active role of glial cells in familial and sporadic motor neuron disease2011
- Author(s)
  Yamanaka K
- Organizer
  The 9th Biennial Conference of the Chinese Neuroscience Society
- Place of Presentation
  Zhengzhou, China
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] The active role of glial cells in familial and sporadic motor neuron disease2011
- Author(s)
  Yamanaka K
- Organizer
  The 9th Biennial Conference of the Chinese Neuroscience Society
- Place of Presentation
  Zhengzhou, China(招待講演)
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Elimination of innate immune system adaptor TRIF significantly accelerates disease progression of ALS mice2011
- Author(s)
  Yamanaka K, et al, 他2名
- Organizer
  22nd International Symposium on ALS/MND
- Place of Presentation
  Sydney, Australia
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] ALSにおけるグリア関連病態2011
- Author(s)
  山中宏二
- Organizer
  第52回日本神経学会学術大会シンポジウム
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Active roles of glial cells in non-cell autonomous neurodegeneration in ALS2011
- Author(s)
  Yamanaka K.
- Organizer
  第34回日本神経科学大会シンポジウム
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] ALSにおけるグリア関連病態2011
- Author(s)
  山中宏二
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋(シンポジウム)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PUBLICLY-23110523
[Presentation] 神経変性疾患における非細胞自律性の神経細胞死2010
- Author(s)
  山中宏二
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)ワークショップ
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] The role of glial cells in ALS.2010
- Author(s)
  Yamanaka K.
- Organizer
  Neuro2010(第33回日本神経科学大会,日本神経化学会,合同大会)シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Active roles of glial cells in neurodegenerative disease2010
- Author(s)
  Yamanaka K
- Organizer
  International Conference on Systems in Medicine and Biology
- Place of Presentation
  Kharagpur, India
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] The role of glial cells in ALS. Neuro20102010
- Author(s)
  Yamanaka K
- Organizer
  (第33回日本神経科学大会,日本神経化学会,合同大会)シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Active roles of glial cells in neurodegenerative disease.2010
- Author(s)
  Yamanaka K.
- Organizer
  International Conference on Systems in Medicine and Biology
- Place of Presentation
  Kharagpur, India
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 神経変性疾患における非細胞自律性の神経細胞死, BMB20102010
- Author(s)
  山中宏二
- Organizer
  (第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)ワークショップ
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009
- Author(s)
  山下博史, 山中宏二, 他
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20023034
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009
- Author(s)
  Yamanaka K
- Organizer
  The 3rd Korea-Japan Neuroscience Symposium
- Place of Presentation
  釜山
- Year and Date
  2009-08-26
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009
- Author(s)
  山中宏二
- Organizer
  The 3rd Korea-Japan Neuroscience Symposium
- Place of Presentation
  Busan, Korea
- Year and Date
  2009-08-26
- Data Source
  KAKENHI-PROJECT-20023034
[Presentation] Controlling neuroinflammation through glial cells are viable target for the therapy to slow neurodegeneration in ALS2009
- Author(s)
  山中宏二
- Organizer
  第32回日本神経科学会大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20023034
[Presentation] 細胞特異的トランスクリプトームを用いたALSマウス脊髄DNAマイクロアレイの解析2009
- Author(s)
  山下博史, 山中宏二, 他
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Controlling neuroinflammation through glial cells are viable target for the therapy to slow neurodegeneration in ALS2009
- Author(s)
  Yamanaka K
- Organizer
  第32回日本神経科学会大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2009
- Author(s)
  山中宏二
- Organizer
  The 3rd Korea-Japan Neuroscience Symposium
- Place of Presentation
  釜山(韓国)
- Year and Date
  2009-08-26
- Data Source
  KAKENHI-PROJECT-21390274
[Presentation] Astrocytes and microglia determine disease progression in amyotrohic lateral sclerosis2008
- Author(s)
  Koji Yamanaka
- Organizer
  Cold Spring Harbor 2008 Meeting on Glia in Health & Disease
- Place of Presentation
  Cold Spring Harbor, USA
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Astrocytes and microglia determine disease progression in amyrotrohic lateral sclerosis.2008
- Author(s)
  Koji Yamanaka
- Organizer
  Cold Spring Harbor 2008 Meeting on Glia in Health & Disease
- Place of Presentation
  Cold Spring Harbor, USA
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-20023034
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2008
- Author(s)
  Koji Yamanaka
- Organizer
  BMB2008(第81回日本生化学会, 第31回日本分子生物学会合同大会)シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20023034
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegeneration in ALS2008
- Author(s)
  Yamanaka K.
- Organizer
  BMB2008 (第81回日本生化学会,第31回日本分子生物学会合同大会) シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Glial cells as central contributors to non-cell autonomous neurodegener ation in ALS.2008
- Author(s)
  Koji Yamanaka
- Organizer
  BMB2008(第81回日本生化学会, 第31回日本分子生物学会合同大会)シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Astrocytes and microglia determine disease progression in amyotrohic lateral sclerosis2008
- Author(s)
  Yamanaka K.
- Organizer
  Cold Spring Harbor 2008 Meeting on Glia in Health & Disease.
- Place of Presentation
  Cold Spring Harbor, USA
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as terminant of disease profression in ALS.2007
- Author(s)
  Koji Yamanaka
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as determinant of disease progression in ALS.2007
- Author(s)
  Koji Yamanaka
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19044048
[Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice2007
- Author(s)
  Yamanaka K.
- Organizer
  18th International Symposium on ALS/MND,
- Place of Presentation
  Toronto, Canada
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007
- Author(s)
  山中宏二
- Organizer
  第48回日本神経学会総会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007
- Author(s)
  山中宏二
- Organizer
  第48回日本神経学会総会シンポジウム
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19044048
[Presentation] 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二
- Organizer
  第27回日本医学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-19044048
[Presentation] 神経変性疾患の動物モデルー筋萎縮性側索硬化症2007
- Author(s)
  山中宏二
- Organizer
  第48回日本神経学会総会シンポジウム
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二
- Organizer
  第27回日本医学会総会
- Place of Presentation
  大阪
- Year and Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice.2007
- Author(s)
  Koji Yamanaka
- Organizer
  18th Intemational Symposium on ALS/MND
- Place of Presentation
  Toronto,Canada
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Selective gene ablation of mutant SOD1 in astrocytes significantly slows disease progression of ALS mice.2007
- Author(s)
  Koji Yamanaka
- Organizer
  18th International Symposium on ALS/MND
- Place of Presentation
  Toronto, Canada
- Year and Date
  2007-12-02
- Data Source
  KAKENHI-PROJECT-19044048
[Presentation] 非細胞自律性の神経細胞死2007
- Author(s)
  山中宏二
- Organizer
  第27回日本医学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] Selective gene ablation of mutant SOD1 in mice identifies astrocytes as determinant of disease progression in ALS2007
- Author(s)
  Yamanaka K.
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19591021
[Presentation] 神経変性疾患ALSにおける自然免疫機構の役割
- Author(s)
  山中宏二
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Motor neuron-derived osteopontin is an aggravation factor in the disease onset of ALS mice
- Author(s)
  Niikura M, Tanabe S, Moriwaki Y, Yamanaka K, Misawa H.
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] 筋萎縮性側索硬化症モデルマウスにおけるアクアポリン4の発現変動
- Author(s)
  岩崎愛里, 中田俊輔, 森脇康博, 奥田隆志, 山中宏二, 阿部陽一郎, 安井正人, 三澤日出巳.
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] 変異SOD1由来の毒性に対するシスタチンCの神経細胞保護機構の解明
- Author(s)
  渡邊征爾, 若杉桂輔, 山中宏二
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25860252
[Presentation] 運動神経変性疾患に共通するスプライソソーム異常
- Author(s)
  築地仁美、井口洋平、古屋亜佐子、片岡礼音、村山繁雄、祖父江元、山中宏二
- Organizer
  第５４回日本神経病理学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] 自然免疫TRIF経路遮断によってALS疾患の進行が顕著に加速する
- Author(s)
  小峯起, 藤森典子, 山下博史, 森脇康博, 三澤日出巳, 山中宏二.
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] Osteopontin/CD44 pathway in a mouse model of amyotrophic lateral sclerosis
- Author(s)
  大西晃輔, 森脇康博, 新倉麻己子, 森崎祐太, 山中宏二, 三澤日出巳.
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-25293020
[Presentation] Region-specific changes in gene expression in transgenic TDP-43 mouse displaying impaired memory
- Author(s)
  Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Koji Yamanaka
- Organizer
  The Nineteenth Annual Meeting of the RNA Society
- Place of Presentation
  ケベック、カナダ
- Year and Date
  2014-06-03 – 2014-06-08
- Data Source
  KAKENHI-PROJECT-25430055
[Presentation] Coordinated activation of autophagy and Cathepsin-mediated proteolysis inhibition is essential for neuroprotection by Cystatin C against mutant SOD1-mediated toxicity.
- Author(s)
  Watanabe S, Wakasugi K, Yamanaka K
- Organizer
  25th International Symposium on ALS/MND
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25860252

1. YAMASHITA Hirofumi (60402913)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. WATANABE Seiji (70633577)

# of Collaborated Projects: 5 results

# of Collaborated Products: 29 results
3. MISAWA Hidemi (80219617)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. Takumi Toru (00222092)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. KUROKAWA Yoichi (40326088)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Takahashi Ryosuke (90216771)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. KOMINE Okiru (00456211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
8. ENDO Fumito (10713307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
9. 高橋英機 (40446521)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. WATANABE Shoji (80462745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kiyama Hiroshi (00192021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Higuchi Makoto (10373359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Uchiyama Yasuo (10049091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Hattori Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Kawakami Hideshi (70253060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Urushitani Makoto (60332326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MORIWAKI Yasuhiro (00392150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. Suzumura Akio (50196896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Takeuchi Hideyuki (30362213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Suganami Takayoshi (50343752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OHIGASHI Hajime (80026583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KANO Kenji (10152828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IRIE Kazuhiro (00168535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. Tsuiji Hitomi (40455358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
25. 祖父江顕 (80823343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
26. 岡田洋平 (30383714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. FUJIMORI Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. Itoh Michiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. MURAKAMI Kazuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 山中智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 貫名信行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 古川良明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 阿部学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. LASIENE JURATE

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 石原健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 高尾英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 伊佐正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 高橋淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 木下専

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 川出野絵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 小野寺一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamanaka Koji 山中 宏二

YAMANAKA Koji 山中 宏二

Research Projects

Research Products

Co-Researchers

TDP-43病理形成・分解機序に着目した筋萎縮性側索硬化症の分子病態解明と制御Principal Investigator

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タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発Principal Investigator

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Identifying mechanisms of motor neuron degeneration through ER-mitochondria interactionPrincipal Investigator

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Elucidating molecular pathology of ALS through TBK1 gene networkPrincipal Investigator

Principal Investigator

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グリア・末梢免疫連関の制御を通じた神経変性機序の解明と治療標的同定Principal Investigator

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Role of the crosstalk between liver and brain in the pathophysiology of liver fibrosis

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Investigation on antioxidants with low pro-oxidant activity to stabilize proteins responsible for neurodegenerative disease.

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Elucidating pathomechanism of ALS through the abnormality in astrocytesPrincipal Investigator

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Cell-autonomous and non-cell-autonomous mechanisms of neurodegeneration in ALS

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Disruption of mitochondria-associated membrane in neurodegenerative disease

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Common defects of RNA metabolism in motor neuron diseases SMA and ALS

Principal Investigator

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Microarray analysis in spinal cords of sporadic ALS patients with cell-type specific transcriptome

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神経-グリアネットワーク変調が来す運動神経変性機序の解明Principal Investigator

Principal Investigator

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Yamanaka Koji 山中宏二

YAMANAKA Koji 山中宏二