Horiuchi Hisanori 堀内久徳

… Alternative Names

HORIUCHI Hisanori 堀内久徳

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Researcher Number	90291426
Other IDs
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Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 研究員 2025: 東北大学, 加齢医学研究所, 非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 加齢医学研究所, 非常勤講師 2009 – 2022: 東北大学, 加齢医学研究所, 教授 2010 – 2012: 東北大学, 加齢研究所, 教授 2005 – 2009: Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 講師 2007: 京都大学, 医学研究科, 助手 … More 2007: 京都大学, 大学院・医学研究科, 講師 2006: 京都大学, 大学院医学系研究科, 講師 1997 – 2005: 京都大学, 医学研究科, 助手 1998 – 2001: 京都大学, 医学研究所, 助手 1999: 京都大学, 大学院・医学研究科, 助手 1997: 京都大学, 大学院・医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / General medical chemistry / Biological Sciences / Functional biochemistry / Basic Section 54010:Hematology and medical oncology-related / Pathological medical chemistry / Circulatory organs internal medicine / Tumor biology / Biological Sciences / Tumor biology … More Except Principal Investigator … More Metabolomics / Biological Sciences / Basic Section 55030:Cardiovascular surgery-related / Respiratory organ internal medicine / Metabolomics / Basic Section 90110:Biomedical engineering-related / Basic Section 55020:Digestive surgery-related / Basic Section 53010:Gastroenterology-related / Kidney internal medicine / Urology / Pediatrics Less
Keywords	Principal Investigator Ral / 低分子量GTP結合蛋白質 / GTP結合蛋白質 / Munc13-4 / がん / Rab / Rab27 / GAP / 血小板 / Rabex5 … More / エンドサイトーシス / Rab5 / GTP交換因子 / GDP / 小胞輸送 / Rasファミリー / adiponectin / AMPK / GLUT4 / GTP結合蛋白 / Rad / RalGAP / 第VIII因子 / 凝固第VIII因子 / ずり応力 / フォンウィルブランド因子 / HMGB1 / low density lipoprotein / hemophilia / nanobody / 低比重リポ蛋白質 / 血友病 / ナノボディ / エンドソーム / LDL受容体 / 家族性高コレステロール血症 / 低比重リポ蛋白質受容体 / PCSK9 / シグナル伝達 / 分子病態学 / 低分子量GTP結合タンパク質 / Ｒａｌ / 代謝 / 好中球 / PAD4 / 翻訳後修飾 / 蛋白質シトルリン化 / hemophagocytic syndrome / adaptor protein / integrin / aggregation / dense granule / GTP binding protein / platelet / カルシウム / エキソサイトーシス / C-キナーゼ / 凝集 / 血球貪食症候群 / アダプター蛋白質 / インテグリン / 凝集反応 / 濃染顆粒 / exocyst complex / gene trap / adipocytes / ストレプトライシン-O / エクソサイトーシス / グルコーストランスポータ4 / lipolysis / 分化因子 / 脂肪滴 / streptolysin-O / 開口放出 / インスリン / exocyst複合体 / アディポネクチン / 遺伝子トラップ法 / 脂肪細胞 / skeletal muscle / diabetes mellitus / GTPase / 骨格筋 / 骨格 / 糖尿病 / rRNA / 小胞体ストレス / RasL11 / RasL10 / RabL11 / RabL10 / リボソーム / 核小体 / 炎症 / GTP結合蛋白室 / がん抑制遺伝子 / 腫瘍 / カルシウムセンサー / Muncl3-4 / Rab15 / 調節性開口放出 / 癌 / 膀胱癌 / (4)膀胱癌 / (3)癌 / (2)Ral / (1)低分子量GTP結合蛋白質 / RaIGAP / アクチン / Rho / 内皮細胞 / Gem … More Except Principal Investigator LOX-1 / SR-PSOX / MCP-1 / Rab4 / 動脈硬化 / Lysophosphatidylcholine / Egr-1 / JAM / 血小板 / oxidized LDL / 粥状動脈硬化 / 酸化LDL / 小胞輸送 / 補助人工心臓 / 消化管出血 / 後天性フォンウィルブランド症候群 / せん断応力 / フォンウィルブランド因子 / 出血性合併症 / atherosclerosis / ケモカイン / マクロファージ / サイトカイン / リゾフォスファチジルコリン / 血管内皮細胞 / 内皮細胞 / MSW / TGF-β / PKCα / 顆粒放出 / Ral / 間欠的低酸素 / 持続的低酸素 / 閉塞型睡眠時無呼吸 / 血行力学的環境応答 / 補助循環 / 血液剪断負荷 / 非臨床評価 / 後天性von Willebrand症候群 / 血栓性合併症 / 発癌 / 低分子量GTP結合蛋白 / gemcitabine / ATM / 膵癌 / 消化管血管異形成 / フォンウィルブランド因子高分子多量体 / 大動脈弁狭窄症 / 高ずり応力 / 貧血 / 経カテーテル的大動脈弁植え込み術 / 消化管粘膜血管異形成 / ハイド症候群 / 重症大動脈弁狭窄症 / 出血合併症 / 重症心不全 / 植込型補助人工心臓 / chemokine / prostaglandin / integrin / granule secretion / platelet / Oxidized LDL receptor / プロスタグランディン / インテグリン / 酸化LDL受容体 / PDGF receptor / Gsr6 / plate activation / 血栓 / 細胞遊走 / 細胞接着 / スカベンジャー受容体 / PDGF受容体 / Gas6 / 血小板活性化 / promoter / glomerulosclerosis / transcription factor / mesangial cell / 核転送 / プロモーター / 糸球体硬化症 / 転写因子 / メサンギウム細胞 / Granule release / Platelet / Accumulation of abnormal proteins / ES cells / Apg proteins / Autophagosomes / Autophagy / Aab5結合蛋白質 / Aab5 overlay法 / Rab蛋白質 / 受容体再循環 / GFP / AAA型ATPase / RabGTPase / 顆粒放出反応 / 輸送再構成形 / 優性阻害変異体 / Beclin / SKD1 / エンドソーム / 異常蛋白質の蓄積 / ES細胞 / Apg蛋白質 / オートファゴソーム / オートファジー / 転移 / GAP / GAP(GTPase-activating protein) / 前立腺癌 / 膀胱癌 / 呼気一酸化炭素 / 酸化ストレス / heme oxygenase-1 / 睡眠時無呼吸 / 遺伝子多型 / 持続気道陽圧 / 睡眠時睡眠時無呼吸 / メタボリック症候群 / HIF-1 / 心血管障害 / 血小板凝集能 / メタロプロテアーゼ / メタボリックシンドローム / エネルギー代謝 / FHL / 調節性開口放出 / 細胞性免疫 / 細胞傷害性T細胞 / ウィルス / syntaxin 11 / perforin / Munc13-4 / 家族性血球貧食症候群 / 遺伝子診断 / 血球貪食症候群 / 膜融合 / 開口放出 / 低分子量GTPase / 超分子複合体 / 電子顕微鏡 / X線結晶構造解析 / 適正治療 / 発現アレイ解析 / 連鎖解析 / CTL活性 / 遺伝子異常 / 血球貧食症候群 Less

個別化抗血栓療法の確立にむけた補助人工心臓患者における血小板機能変容の解明
- Principal Investigator
  
  片平晋太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Tohoku University
Research of high-shear stress-induced hemostatic disorderPrincipal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tohoku University
Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist
- Principal Investigator
  
  白石泰之
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tohoku University
Development of bi-specific nanobody capable of thrapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Horiuchi Hisanori
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tohoku University
Study of formation and disappearance of gastrointestinal angiodysplasia that is associated with high shear stress
- Principal Investigator
  
  Inoue Ken
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
al analysis of small G protein Ral in pancreatic carcinogenesis and acquisition of invasive potential
- Principal Investigator
  
  Ohtsuka Hideo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Establishment of Preoperative Prediction System for Bleeding Complications in Patients with Implantable Left Ventricular Assist Devices
- Principal Investigator
  
  Saiki Yoshikatsu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Tohoku University
Molecular mechanism of alteration of intracellular traffic of LDL receptor by PCSK9Principal Investigator
- Principal Investigator
  
  Horiuchi Hisanori
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tohoku University
Elucidation of regulatory mechanism of diseases mediated by small GTP ase RalPrincipal Investigator
- Principal Investigator
  
  Horiuchi Hisanori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
Elucidation of regulatory factors for protein citrullination and their roles in biological functionsPrincipal Investigator
- Principal Investigator
  
  Hisanori Horiuchi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Elucidation of roles of small GTPase Ral and its negative regulator RalGAP in tumorigenesis, and cancer invasion and metastasisPrincipal Investigator
- Principal Investigator
  
  Horiuchi Hisanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Elucidation of molecular mechanism of nucleolar stress with a novel in vitro assayPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Hisanori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
低分子量ＧＴＰ結合蛋白質Ｒａｌを介した細胞内ロジスティクスPrincipal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Roles of small GTPase Ral in tumorigenesisPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Hisanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Gene polymorphisms in patients with sleep apnea and cell responses to hypoxia
- Principal Investigator
  
  TSUBOI Tomomasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto University
Research for a mechanism of urologic cancer metastasis through a GAP signaling pathway
- Principal Investigator
  
  OKUBO Kazutoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University
がん化における低分子量GTP結合蛋白質Ralの機能Principal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Identification of NRDc, a novel key molecule for energy metabolism. Pathophysiological role of NRDc in Metabolic Syndrome
- Principal Investigator
  
  NISHI Eiichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.
- Principal Investigator
  
  CHIN Kazuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto University
開口放出で働く繋留因子Exocyst複合体の立体構造解析
- Principal Investigator
  
  深井周也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Tokyo Institute of Technology
家族性血球貪食症候群の迅速診断法の確立とその類縁疾患の解析
- Principal Investigator
  
  秦大資
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Tazuke Kofukai Medical Research Institute
家族性血球貧食症候郡における責任遺伝子の同定と疾患再分類化による適正治療法の開発
- Principal Investigator
  
  石井榮一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Saga University
Molecular mechanism of the process from atherosclerotic lesion formation to plaque rupture
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Elucidation of molecular mechanism of exocytosis in adipocytesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Hisanori
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Identification and functional analysis of novel proteins regulating platelet activation which triggers arterial thrombosis.Principal Investigator
- Principal Investigator
  
  HORIUCHI Hisanori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Elucidation of molecular mechanism of atherosclerosis formation
- Principal Investigator
  
  YOKODE Msayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
活性化された血管内皮細胞に発現誘導される低分子量GTP結合蛋白質Gemの機能解明Principal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Molecular mechanism of activation of endothelial cells involved in early stage of atherosclerosis formation.
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Functional expression of small GTPase Rad, highly expressed in skeletal muscle in diabetic patientsPrincipal Investigator
- Principal Investigator
  
  HISANORI Horinow
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYOTO UNIVERSITY
Cell biological study for atherosclerosis
- Principal Investigator
  
  KITA Toru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
低分子量のG蛋白質Rab5が統御する小胞輸送の分子的解明と分子シャペロンの関係Principal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Proteins as functional elements of the machinery for the post-Golgi transport network
- Principal Investigator
  
  YOSHIMORI Tamotsu
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  OKAZAKI NATIONAL RESEACH INSTITUTES
  Okazaki National Research Institutes
Investigation for progressive factors of glomerulosclerosis.
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
  Kyoto University
低分子量G蛋白質Rab5が制御する小胞輸送の分子的解明と分子シャベロンの関係Principal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
低分子量GTP結合蛋白Rab5のエンドサイトーシス経路における制御機構Principal Investigator
- Principal Investigator
  
  堀内久徳
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University

[Book] 「血小板顆粒放出異常症と遺伝子異常」高久史麿血、小澤敬也、坂田洋一、金倉譲、小島勢二編2013
- Author(s)
  白川龍太郎、堀内久徳
- Publisher
  Annual review血液2013
- Data Source
  KAKENHI-PROJECT-22501009
[Book] 「胸痛」北徹監修、横出正之、荒井秀典編健康長寿大事典:QOLからEBMまで2012
- Author(s)
  堀内久徳
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-22501009
[Book] 「mTOR」日本血管生物医学会編集「血管生物医学事典」2011
- Author(s)
  堀内久徳
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22501009
[Book] 「低分子量GTP結合蛋白質」日本血管生物医学会編集「血管生物医学事典」2011
- Author(s)
  堀内久徳
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-22501009
[Book] 疾患モデルの作製と利用「循環器疾患」2010
- Author(s)
  北徹、堀内久徳、柳田素子、猪原匡史、冨本秀和、並河徹編
- Publisher
  Life-science Information Center社
- Data Source
  KAKENHI-PROJECT-22501009
[Journal Article] Acute changesin von Willebrand factor degradation after the deterioration of aortic dissection model in vivo2024
- Author(s)
  Fukai M, Shiraishi Y, Chikweto F, Kobayashi M, Hou X, Fukaya A, Ikura M, Hanzawa K, Horiuchi H, Yambe T
- Journal Title
  
  Proc Int Conf Biomed Eng (ICOBE2023)
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K25186
[Journal Article] Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production2023
- Author(s)
  Cao Mingxin、Li Xinming、Trinh Duc-Anh、Yoshimachi Shingo、Goto Kota、Sakata Natsumi、Ishida Masaharu、Ohtsuka Hideo、Unno Michiaki、Wang Yuxia、Shirakawa Ryutaro、Horiuchi Hisanori
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 6 Pages: 104754-104754
- DOI
  10.1016/j.jbc.2023.104754
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08791
[Journal Article] Gastrointestinal Angiodysplasia before and after Treatment of Severe Aortic Stenosis2023
- Author(s)
  Yashige Masaki、Inoue Ken、Zen Kan、Kobayashi Reo、Nakamura Shunsuke、Fujimoto Tomotaka、Takamatsu Kazuaki、Sugino Satoshi、Yamano Michiyo、Yamano Tetsuhiro、Nakamura Takeshi、Doman Tsuyoshi、Teramukai Satoshi、Horiuchi Hisanori、Itoh Yoshito、Matoba Satoaki
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 389 Issue: 16 Pages: 1530-1532
- DOI
  10.1056/nejmc2306027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07967, KAKENHI-PROJECT-23K25186
[Journal Article] Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP2016
- Author(s)
  3.K. Shishikura, T. Horiuchi, N. Sakata, D-A Trinh, R. Shirakawa, T. Kimura, Y. Asada, H. Horiuchi*
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 2 Pages: 319-331
- DOI
  10.1111/bph.13373
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15060, KAKENHI-PROJECT-15K19000, KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis.2015
- Author(s)
  Shirakawa R, Horiuchi H.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 157 Issue: 5 Pages: 285-299
- DOI
  10.1093/jb/mvv029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860181, KAKENHI-PROJECT-25290041
[Journal Article] Ral GTPases: Crucial Mediators of Exocytosis and Tumorigensis. (a review)2015
- Author(s)
  R. Shirakawa, H. Horiuchi
- Journal Title
  
  J Biochem (tokyo)
  
  Volume: in press
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290041
[Journal Article] The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production2014
- Author(s)
  Kimura T, Shirakawa R, Yaoita N, Hayashi T, Nagano K, Horiuchi H
- Journal Title
  
  FEBS letters
  
  Volume: 588 Issue: 20 Pages: 3673-3676
- DOI
  10.1016/j.febslet.2014.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins2014
- Author(s)
  Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S
- Journal Title
  
  Cellular Signalling
  
  Volume: 26 Issue: 8 Pages: 1636-1648
- DOI
  10.1016/j.cellsig.2014.04.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121703, KAKENHI-PROJECT-25290041, KAKENHI-PROJECT-26860181
[Journal Article] Downregulation of Ral GTPase-activating-protein causes tumor invasion and metastasis of bladder cancer2013
- Author(s)
  R Saito, R Shirakawa, H Nishiyama, T Kobayashi, M Kawato, T Kanno, K Nishizawa, Y Matsui, T Ohbayashi, M Horiguchi, T Nakamura, T Ikeda, K Yamane, E Nakayama, E Nakamura, Y Toda, T Kimura, T Kita, O Ogawa, H Horiuchi
- Journal Title
  
  Oncogene 32
  
  Pages: 894-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009
[Journal Article] Rab-genome analysis of Weibel Palade body exocytosis reveals an unexpected linkbetween exocytic and endocytic RabGTPases2012
- Author(s)
  S. Zografou, D. Basagiannis, A.Papafotika, R. Shirakawa, H. Horiuchi, D. Auerbach, M. Fukuda, S. Christoforidis
- Journal Title
  
  J Cell Sci 25
  
  Volume: 125巻 Pages: 4780-4790
- DOI
  10.1242/jcs.104174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-24700961, KAKENHI-PLANNED-20113006, KAKENHI-PUBLICLY-23113702
[Journal Article] Munc13-4 reconstitutes Ca^<2+>-dependent SNARE-mediated membrane fusion2012
- Author(s)
  K Boswell, D James, J Esquibel, S Bruinsma, R Shirakawa, H Horiuchi, T Martin*
- Journal Title
  
  J Cell Biol 197
  
  Volume: 197 Issue: 2 Pages: 301-312
- DOI
  10.1083/jcb.201109132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503, KAKENHI-PROJECT-24700961
[Journal Article] Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocytes differentiation2011
- Author(s)
  Shirai, Y, Sakai, N., 他
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 22 Issue: 8 Pages: 1340-1352
- DOI
  10.1091/mbc.e10-09-0754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390049, KAKENHI-PROJECT-22501009
[Journal Article] Rapid diagnosis of familial hemophagocytic lymphohistiocytosis type 3 (FHL3) by flow cytometric detection of intraplatelet Munc 13-4 protein.2011
- Author(s)
  Murata Y., Yasumi T., Shirakawa R., Izawa K., Sakai H., Abe J., Tanaka N., Kawai T., Oshima K., Saito M., Nishikomori R., Ohara O.、Ishii E., Nakahata T., Horiuchi H., Heike T.
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 5 Pages: 1225-1230
- DOI
  10.1182/blood-2011-01-329540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-22591159, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503
[Journal Article] Flightless-I (Fli-I) regulates the actin assembly activity of Diaphanous-related formins (DRFs), Daam1 and mDia1, in cooperation withactive Rho GTPase2010
- Author(s)
  T. Higashi, T. Ikeda, T. Murakami, R.Shirakawa, M. Kawato, K. Okawa, M. Furuse, T. Kimura, T. Kita, H. Horiuchi
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Issue: 21 Pages: 16231-16238
- DOI
  10.1074/jbc.m109.079236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501009
[Journal Article] Clopidogrel Resistance in Japanese Patients Scheduled for Percutaneous Coronary Intervention.2009
- Author(s)
  Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto H, Akao M, Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa N, Jinnai T, Takahashi K, Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C, Morimoto T, Kita T, Kimura T.
- Journal Title
  
  Circ J. 73
  
  Pages: 336-342
- NAID
  110007042175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390255
[Journal Article] Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention2009
- Author(s)
  Hoshino K, Horiuchi H, Tada T, Tazaki J, Nishi E, Kawato M, Ikeda T, Yamamoto H, Akao M, Furukawa Y, Shizuta S, Toma M, Tamura T, Saito N, Doi T, Ozasa N, Jinnai T, Takahashi K, Watanabe H, Yoshikawa Y, Nishimoto N, Ouchi C, Morimoto T, Kita T, Kimura T.
- Journal Title
  
  Circ J 73
  
  Pages: 336-342
- NAID
  110007042175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390255
[Journal Article] The Impact of CYP2C19 Polymorphism on the antiplatelet effect of clopidogrel in the real clinical setting2009
- Author(s)
  T. Jinnai, H. Horiuchi, T. Makiyaia, J. Tazaki, T. Tada, M. Akao, K. Ono, K. Hoshino, Y. Naruse, K. Takahashi, H. Watanabe, T. Kita, E Kimura
- Journal Title
  
  Circ. J (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention2009
- Author(s)
  K. Hoshino, H. Horiuchi, T. Tada, J. Tazaki, E. Nishi, M. Kawato, T. Ikeda, H. Yamamoto, M. Akao, Y. Furukawa, S. Shizuta, M. Toma, T. Tamura, N. Saito, T. Doi, N. Ozasa, T. Jinnai, K. Takahashi, H. Watanabe, Y. Yoshikawa, N. Nishimoto, C. Ouchi, T. Morimoto, T. Kita, T. Kimura
- Journal Title
  
  Circ. J 73
  
  Pages: 336-342
- NAID
  110007042175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009
- Author(s)
  Oga T, Chin K Horiuchi H, 他11名
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis 16
  
  Pages: 862-869
- NAID
  130004444357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590921
[Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009
- Author(s)
  Oga T, Chin K, Tabuchi A, Sumi K, Takahashi K,Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M'Morimoto T, Mishima M, Kita T, Horiuchi H
- Journal Title
  
  Journal of Atheroclerosis and Thrombosis 16
  
  Pages: 862-869
- NAID
  130004444357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590921
[Journal Article] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related fomins, mDial and Daaml, in platelets.2008
- Author(s)
  T. Higashi, T. Ikeda, R. Shirakawa, H. Kondo, M. Kawato, M. Horiguchi, T. Okuda, K. Okawa, S. Fukai, O. Niireki, T. Kita, H. Horiuchi*
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 8746-8755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390255
[Journal Article] 血小板濃染顆粒放出の低分子量GTP結合蛋白質による制御2008
- Author(s)
  堀内久徳
- Journal Title
  
  日本臨床血液学会雑誌 33(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDial and Daaml, in platelets2008
- Author(s)
  T. Higashi, T. Ikeda, R. Shirakawa, H. Kondo, M. Kawato, M. Horiguchi, T. Okuda, K. Okawa, S. Fukai, O. Nureki, T. Kita, H. Horiuchi
- Journal Title
  
  J Biol Chem 283
  
  Pages: 8746-8755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] GTP-induced dense-granule secretion in platelets is mediated by Ral GTPase-exocyst pathway2008
- Author(s)
  M. Kawato, R. Shirakawa, H. Kondo, T. Higashi, T. Ikeda, S. Fukai, O. Nureki, T. Kita, H. Horiuchi
- Journal Title
  
  J Biol Chem 283
  
  Pages: 166-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] Biochemical characterization of the Rho GTPase-regulated actin assemblyby diaphanous-related formins,mDial and Daam l,in platelets2008
- Author(s)
  T. Higashi, T. Ilceda, R. Shirakawa, 他(堀内は12名中12番目)
- Journal Title
  
  Journal of Biological Chemistry 283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] GTP-induced dense-granule secretion in platelets is mediated by Ral GTPase-exocvst pathwav2008
- Author(s)
  M. Kawato, R. Shirakawa, H. Kondo, 他(堀内は8名中8番目)
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 166-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Aspirin action on whole blood-aggregation evaluated by the screen filtration pressure method2008
- Author(s)
  A. Tabuchi, R. Taniguchi, K. Takahashi, 他(堀内は9名中9番目)
- Journal Title
  
  Circulation Journal
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Sustained release of prostaglandin E1 potentiates the impaired therapeutic angiogenesis by basic fibroblast growth factor in diabetic murine hindlimb ischemia2008
- Author(s)
  Y. Huang, A. Marui, H. Sakaguchi, J. Esaki, Y. Arai, K. Hirose, S. Chandra Bir, H. Horiuchi, T. Maruyama, T. Ikeda, Y. Tabata, M. Komeda
- Journal Title
  
  Circ. J 72
  
  Pages: 1693-1699
- NAID
  110006935614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] Regulation of platelet dense granule secretion by the Ral GTPase-Exocyst pathway2008
- Author(s)
  Kawato, M., Shirakawa, R., Kondo, H., Higashi, T., lkeda, T., Okawa, K., Fukai, S., Kita, T., Horiuchi, H.
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 166-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18054009
[Journal Article] GTP-induced dense-granule secretion, in platelets is mediated by Ral GTPase-exocyst pathway.2008
- Author(s)
  M. Kawato, R. Shirakawa, H. Kondo, T. Higashi, T. Ikeda, S. Fukai, O. Nuieki, T. Kita, H. Horiuchi*
- Journal Title
  
  J Biol Cheni. 283
  
  Pages: 166-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390255
[Journal Article] Aspirin action on whole blood-aggregation evaluated by the screen filtration pressure method2008
- Author(s)
  A. Tabuchi, R. Taniguchi, K. Takahashi, H. Kondo, M. Kawato, T Morimoto, T. Kimura, T. Kita, H. Horiuchi
- Journal Title
  
  Circ J 72
  
  Pages: 420-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets2008
- Author(s)
  Higashi, T. Ikeda, T., Shirakawa, R., Kondo, H., Kawato, M., Horiguchi, M. Okuda, T., Okawa, K., Fukai, S., Nureki, O., Kita, T., Horiuchi, H.
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 8746-8755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18054009
[Journal Article] Evaluation of the antiplatelet effects of cilostazol, a phosphodiesterase 3 inhibitor, by VASP phosphorylation and platelet aggregation2008
- Author(s)
  H. Yamamoto, K. Takahashi, H. Watanabe, Y. Yoshikawa, R. Shirakawa, T. Higashi, M. Kawato, T. Ikeda, A. Tabuchi, T. Morimoto, T. Kita, H. Horiuchi
- Journal Title
  
  Circ. J 72
  
  Pages: 1844-1851
- NAID
  110006975578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013021
[Journal Article] 血球貪食症候群の発症機序-生化学-2008
- Author(s)
  堀内久徳
- Journal Title
  
  血液腫瘍科 57 supple 6
  
  Pages: 23-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Incidence and outcome of hemophagocytic lymphohistiocytosis (HLH) in Japan : results from the Japan Hemophagocytic Syndrome Study Group2007
- Author(s)
  H.Horiuchi他(堀内は13名中8番目)
- Journal Title
  
  Int. J. Hematol (In press)
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Recurrent hemophagocytic lymphohistiocytosis accompanied by Kikuchi's disease2007
- Author(s)
  Lin YW, Horiuchi H, Ueda l, Nambu M.
- Journal Title
  
  Leukemia and Lymphoma 48
  
  Pages: 2447-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis2007
- Author(s)
  K. Nagafuji, A. Nonami, T. Kumano, 他(堀内は12名中10番目)
- Journal Title
  
  Haematologica 92
  
  Pages: 978-981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Crystal structure of human DAAM1 formin homology 2 domain2007
- Author(s)
  Yamashita, M., Higashi, T., Suetsugu, S., Sato, Y., Ikeda, T., Shirakawa, R., Kita, T., Takenawa, T., Horiuchi, H., Fukai, S., Nureki, O.
- Journal Title
  
  Genes to Cells 12
  
  Pages: 1255-1265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18054009
[Journal Article] Crystal structure of human DAAM l formin homology 2 domain2007
- Author(s)
  M. Yamashita, T. Higashi, S. Suetsugu, 他(堀内は11名中9番目)
- Journal Title
  
  Genes to Cells 12
  
  Pages: 1255-1265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Serum adiponectin level is an independent predictor of mortality in patients with congestive heart failure2007
- Author(s)
  T.Tamura他(堀内は9名中6番目
- Journal Title
  
  Circ. J (In press)
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Nation-wide survey analysis of hemophagocytic lymphohistiocytosis(HLH)in Japan2007
- Author(s)
  E. Ishii, S. Ohga, S. Imashuku, 他(堀内は14名中8番目)
- Journal Title
  
  International Journal of Hematology 86
  
  Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Serum adiponectin level is an independent predictor of mortality in patients with congestive heart failure2007
- Author(s)
  T. Tamura, Y. Furukawa, R. Taniguchi, 他(9名中尾野は5番目、堀内は6番目)
- Journal Title
  
  Circulation Journal 71
  
  Pages: 623-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Asymmetric coiled-coil structure with guanine nucleotide exchange activity2006
- Author(s)
  Y.Sato, R.Shirakawa, H.Horiuchi, N.Dohmae, S.Fukai, O.Nureki
- Journal Title
  
  Structure 15
  
  Pages: 245-252
- Data Source
  KAKENHI-PROJECT-18054009
[Journal Article] Recent advance in antiplatelet therapy : mechanisms, evidence and approach to the problems.2006
- Author(s)
  H.Horiuchi
- Journal Title
  
  Ann.Med 38
  
  Pages: 162-172
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Recent advance in antiplatelet therapy : mechanisms, evidence and approach to the problems.2006
- Author(s)
  H.Horiuchi
- Journal Title
  
  Ann. Med 38
  
  Pages: 162-172
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets2006
- Author(s)
  H.Kondo他(7名中堀内は7番目)
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 28657-28665
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people.2006
- Author(s)
  Yamamoto K, Ishii E, Horiuchi H, Yasukawa M, et al.
- Journal Title
  
  J Hum Genet (in press)
- NAID
  10016913189
- Data Source
  KAKENHI-PROJECT-17019053
[Journal Article] Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism.2006
- Author(s)
  S.Saxena他(3名中堀内は2番目
- Journal Title
  
  Biochem. Biophys. Res. Commun 50
  
  Pages: 600-603
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Recent advance in antiplatelet therapy : mechanisms, evidence and approach to the problems.2006
- Author(s)
  H.Horiuchi(堀内は1名中1番目)
- Journal Title
  
  Ann.Med. (印刷中)
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Recent advance in antiplatelet therapy : mechanisms, evidence and approach to the problems.2006
- Author(s)
  Horiuchi H
- Journal Title
  
  Ann Med 38
  
  Pages: 162-172
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Recent advance in antiplatelet therapy : mechanisms. evidence and approach to the problems. (a review)2006
- Author(s)
  Horiuchi
- Journal Title
  
  Ann Med 38
  
  Pages: 162-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Familial hemophagocytic lymphohistiocytosis with MUNC13-4 mutation : a case report.2006
- Author(s)
  Mizumoto H他(堀内は14名中12番目)
- Journal Title
  
  Eur.J.Pediat. (印刷中)
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Familial hemophagocytic lymphohistiocytosis with MUNC13-4 mutation : a case report2006
- Author(s)
  Mizumoto H他(秦は16名中2番, 堀内は14番)
- Journal Title
  
  Eur. J. Pediat. 165
  
  Pages: 384-388
- Data Source
  KAKENHI-PROJECT-18659308
[Journal Article] Purification and functions analysis of Rab27 effector Munc13-4 using a semi-intact platelet dense-granule secretion assay.2005
- Author(s)
  R.Shirakawa, 他(堀内は6名中6番目)
- Journal Title
  
  Methods Enzymol. 403
  
  Pages: 778-788
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Purification and functional analysis of a Rab27 effector Munc13-4 using a semi-intact platelet dense-granule secretion assay.2005
- Author(s)
  Shirakawa R, Kita T, Horiuchi H
- Journal Title
  
  Methods Enzymol. 403
  
  Pages: 778-788
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209031
[Journal Article] Purification and functional analysis of a Rab27 effector Munc13-4 u sing a semi-intact platelet dense-granule secretion assay.2005
- Author(s)
  Shirakawa R, Kita T, Horiuchi H
- Journal Title
  
  Methods Enzymol. 403
  
  Pages: 778-788
- Data Source
  KAKENHI-PROJECT-16209031
[Journal Article] Purification and functional analysis of a Rab27 effector Munc13-4 using a semi-intact platelet dense-granule secretion assay.2005
- Author(s)
  Shirakawa R, Kita T, Horiuchi H:
- Journal Title
  
  Methods Enzymol. 403
  
  Pages: 778-788
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209031
[Journal Article] Genetic subtypes of familial hemophagocytic lymphohistiocytosis : correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions.2005
- Author(s)
  Ishii E, Yamamoto K, Horiuchi H, Yasukawa M, et al.
- Journal Title
  
  Blood 105
  
  Pages: 3442-3448
- Data Source
  KAKENHI-PROJECT-17019053
[Journal Article] Genetic subtypes of familial hemophagocytic lymphoistiocytosis : correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions.2005
- Author(s)
  E.Ishii, I.Ueda, R.Shirakawa, K.Yamamoto, H.Horiuchi他(堀内は18名中5番目)
- Journal Title
  
  Blood 105
  
  Pages: 3442-3448
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people2005
- Author(s)
  K.Yamamoto, E.Ishii, H.Horiuchi他(堀内は13名中3番目)
- Journal Title
  
  J.Hum.Genet. 50
  
  Pages: 600-603
- NAID
  10016913189
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Primary cardiovascular event and serum lipid levels in elderly Japanese with hypercholesterolemia under 6-Year simvastatin treatment : A sub-analysis of the J-LIT Study2004
- Author(s)
  H. Horiuchi., et al
- Journal Title
  
  J Am Geriatr Soc 52
  
  Pages: 1981-1987
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Journal Article] Primary cardiovascular event and serum lipid levels in elderly Japanese with hypercholesterolemia under 6-Year simvastatin treatment : A sub-analysis of the J-LIT Study.2004
- Author(s)
  H. Horiuchi, et al.
- Journal Title
  
  J Am Geriatr Soc 52
  
  Pages: 1981-1987
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15081206
[Patent] 血液、血球又は凝固関連因子に定量的にずり応力を加える剪断発生装置2023
- Inventor(s)
  山家智之、白石泰之、堀内久徳、松本雅則、早川正樹
- Industrial Property Rights Holder
  山家智之、白石泰之、堀内久徳、松本雅則、早川正樹
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] 補助循環時の後天性フォン・ヴィレブランド症候群を引き起こす流体剪断応答の評価システム制御系開発2023
- Author(s)
  深井実春, 白石泰之, Chikweto Francis, 深谷碧, Narracott Andrew, 早川正樹, 松本雅則, 堀内久徳, 山家智之
- Organizer
  日本人工臓器学会大会61回
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] Acute changesin von Willebrand factor degradation after the deterioration of aortic dissection model in vivo2023
- Author(s)
  Fukai M, Shiraishi Y, Chikweto F, Kobayashi M, Hou X, Fukaya A, Ikura M, Hanzawa K, Horiuchi H, Yambe T
- Organizer
  International Conference on Biomedical Engineering (ICOBE 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] Von Willebrand Factorの応答を考慮したECMOシステムの臨床的評価方法に関する検討2022
- Author(s)
  中野康太郎, 白石泰之, 山田昭博, 深谷碧, 菅野博童, 松浦健, 早川正樹, 松本雅則, 堀内久徳, 山家智之
- Organizer
  第60回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] 後天性フォン・ヴィレブランド症候群に伴う小腸出血性病変の病態2022
- Author(s)
  井上　健, 全　完, 堀内久徳, 他.
- Organizer
  第60回日本小腸学会学術集会, 広島, 2022年11月12日, 主題セッション4「小腸出血に対する診断・治療の最前線」
- Data Source
  KAKENHI-PROJECT-21K07967
[Presentation] 後天性フォン・ヴィレブランド症候群に合併する消化管粘膜血管異形成2022
- Author(s)
  井上　健, 全完, 堀内久徳, 他.
- Organizer
  第44回日本血栓学術集会，会長企画2「後天性フォン・ヴィレブランド症候群と消化管出血」, 仙台, 2022年６月.
- Invited
- Data Source
  KAKENHI-PROJECT-21K07967
[Presentation] OGIBに潜む後天性フォンウィルブランド症候群に伴う消化管出血2022
- Author(s)
  井上　健, 内藤裕二，全　完，堀内久徳，他
- Organizer
  GI week 2022第15回日本カプセル内視鏡学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07967
[Presentation] Prostaglandin E2 inhibits neutrophil extracellular traps formation through production of cyclic AM2015
- Author(s)
  木村朋寛・宍倉匡祐・堀内嵩弘・坂田菜摘・Trinh Duc-Anh・白川龍太郎・堀内久徳
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K15060
[Presentation] セミインタクトシステムによる血小板顆粒放出の分子機構解析2013
- Author(s)
  堀内久徳、白川龍太郎
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京都
- Year and Date
  2013-03-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-23113702
[Presentation] 一般演題「RalGAP発現低下による膀胱癌悪性化」2012
- Author(s)
  堀内久徳、齊藤亮一、白川龍太郎、木村朋寛、松井喜之、西山博之、小川修
- Organizer
  平成24年度日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22501009
[Presentation] 低分子量 G タンパク質 Ral 不活化因子(RalGAP)を介した前立腺癌転移抑制機序の同定2012
- Author(s)
  齊藤亮一、大久保和俊、堀内久徳、小川修ほか
- Organizer
  第100回日本泌尿器科学会総会
- Place of Presentation
  横浜市
- Year and Date
  2012-04-23
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] RalGAP発現低下による膀胱癌悪性化2012
- Author(s)
  堀内久徳
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22501009
[Presentation] RalGAP, the inactivator of Ral small GTPase, suppresses the progression of prostate cancer2012
- Author(s)
  Saito R, Horiuchi H, Ogawa O et al
- Organizer
  27th Annual EAU Congress
- Place of Presentation
  パリフランス
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] RalGAPα2 発現量は膀胱癌の生命予後規定因子のひとつである2012
- Author(s)
  齊藤亮一、堀内久徳、小川修ほか
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] RalGAP による腫瘍浸潤転移抑制機能の新規同定2011
- Author(s)
  齊藤亮一、堀内久徳、小川修ほか
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  第99回日本泌尿器科学会総会
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] RalGAP α2, the inactivator of Ral small GTPase, is a metastasis suppressor of bladder cancer2011
- Author(s)
  Saito R, Horiuchi H, Ogawa O et al
- Organizer
  26th Annual EAU Congress
- Place of Presentation
  ウィーンオーストリア
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] 血小板顆粒放出の分子メカニズム2011
- Author(s)
  堀内久徳
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PUBLICLY-23113702
[Presentation] RalGAPs : negative regulators of Ral GTPases controlling membrane traffic and cancer.2010
- Author(s)
  Hisanori Horiuchi
- Organizer
  第30回札幌国際がんシンポジウム2010
- Place of Presentation
  札幌
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-22501009
[Presentation] RalGAPalpha2 の膀胱癌における役割2010
- Author(s)
  齊藤亮一、堀内久徳、小川修ほか
- Organizer
  第69 階日本癌学会学術総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-22591766
[Presentation] 血小板濃染顆粒放出の分子メカニズム2009
- Author(s)
  堀内久徳、白川龍太郎
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] Clopidogrel Resistance inJapanese Patients Scheduled for Percutaneous Coronary Intervention, Poster Session2009
- Author(s)
  Tada, T, Horiuchi, H, Nagai, K, Tazaki, J, Nishi E, Touma, M, Tamura, T, Akao, M, Furukawa, Y, Kimura, T, Kita T
- Organizer
  The 73^<rd> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-20390255
[Presentation] Molecular dissection of platelet dense granule secretion2008
- Author(s)
  堀内久徳
- Organizer
  第3回UK-Japan Platelet Conference
- Place of Presentation
  シンガポール
- Data Source
  KAKENHI-PROJECT-20390255
[Presentation] 血小板機能評価試験の基礎と日本人PCI施行患者のクロピドグレル反応性2008
- Author(s)
  堀内久徳
- Organizer
  第8回日本心血管カテーテル治療学会学術総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] RalGAPの同定2008
- Author(s)
  堀内久徳、白川龍太郎、深井周也、北徹
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] 活性化血小板における濃染顆粒放出の分子メカニズム2008
- Author(s)
  堀内久徳
- Organizer
  第31回日本血栓止血学会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] RalGAPの同定2008
- Author(s)
  堀内久徳, 白川龍太郎, 深井周也, 北徹
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20390255
[Presentation] Clopidosrel resistance in the Japanese patients2008
- Author(s)
  堀内久徳、木村剛、北徹
- Organizer
  第40回日本動脈硬化学会総会/学術集会
- Place of Presentation
  筑波市
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] Molecular dissection of platelet dense granule secretion2008
- Author(s)
  堀内久徳
- Organizer
  第3回UK-Japan Platelet Conference
- Place of Presentation
  シンガポール
- Data Source
  KAKENHI-PROJECT-20013021
[Presentation] 血小板顆粒放出必須制御系としてのRab27-Munc 13-4の同定とその異常による血球貧食症候群2007
- Author(s)
  堀内久徳
- Organizer
  第69回日本血液学会、第49回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18659308
[Presentation] Identification of Rab27-Muncl3-4 as an essential regulatory system for platelet secretio nhemophagocytic syndrome due its defec2007
- Author(s)
  H. Horiuchi
- Organizer
  The joint Meeting of the 69^<th> JapaneseHematology Sciety Meeting and the 49^<th> Japanese Clinical Hematology Sciety Meeting
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Presentation] 血小板顆粒放出必須制御系としてのRab27-Munc13-4の同定とその異常による血球貪食症候群2007
- Author(s)
  堀内久徳
- Organizer
  第69回日本血液学会、第49回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Presentation] Establishment of a Novel Actin Polymerization Assay Using Cytosol and Characterization of Mammalian Formin Daaml2006
- Author(s)
  T. Higashi, S. Fukai, R. Shirakawa, O. Nureki, T. Kita, H. Horiuchi
- Organizer
  アメリカ細胞生物学会
- Place of Presentation
  San Diego、米国
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Presentation] Elucidation of molecular mechanism of platelet secretion2006
- Author(s)
  H. Horiuchi, et al
- Organizer
  COE International Symposium, Intracellular transport-from molecular mechanism to diseases
- Place of Presentation
  Maebashi
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[Presentation] Elucidation of molecular mechanism of platelet secretion2006
- Author(s)
  H. Horiuchi
- Organizer
  COE国際シンポジウム「細胞内輸送-分子機構から疾患まで」
- Place of Presentation
  前橋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15081206
[]

1. YOKODE Masayuki (20252447)

# of Collaborated Projects: 6 results

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54. 酒井規雄

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# of Collaborated Projects: 0 results

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Horiuchi Hisanori 堀内 久徳

HORIUCHI Hisanori 堀内 久徳

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Research of high-shear stress-induced hemostatic disorderPrincipal Investigator

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Development of bi-specific nanobody capable of thrapeutic applicationPrincipal Investigator

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Molecular mechanism of alteration of intracellular traffic of LDL receptor by PCSK9Principal Investigator

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Elucidation of regulatory mechanism of diseases mediated by small GTP ase RalPrincipal Investigator

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Elucidation of regulatory factors for protein citrullination and their roles in biological functionsPrincipal Investigator

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Elucidation of roles of small GTPase Ral and its negative regulator RalGAP in tumorigenesis, and cancer invasion and metastasisPrincipal Investigator

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Elucidation of molecular mechanism of nucleolar stress with a novel in vitro assayPrincipal Investigator

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低分子量ＧＴＰ結合蛋白質Ｒａｌを介した細胞内ロジスティクスPrincipal Investigator

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Roles of small GTPase Ral in tumorigenesisPrincipal Investigator

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Horiuchi Hisanori 堀内久徳

HORIUCHI Hisanori 堀内久徳