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ARAI Ken-ichi  新井 賢一

ORCIDConnect your ORCID iD *help
Researcher Number 00012782
Other IDs
Affiliation (based on the past Project Information) *help 2000 – 2001: 東京大学, 医科学研究所, 教授
2000 – 2001: 東京大学, 医科研, 教授(所長)
1990 – 1998: 東京大学, 医科学研究所, 教授
1994: 東京大学, 医科研, 教授
1993: 東京大学 医科学研究所, 教授
1991: 東京大学, 医科学研究所(分子生物学、生化学), 教授
1990: 東京大学医科学研究所, 教授
Review Section/Research Field
Principal Investigator
Functional biochemistry / Immunology / Experimental pathology / Structural biochemistry / 広領域 / 代謝生物化学 / General medical chemistry / Cell biology
Except Principal Investigator
Biological Sciences / Functional biochemistry … More / Immunology / Cell biology / 代謝生物化学 / 内科学一般 / 物質生物化学 Less
Keywords
Principal Investigator
サイトカイン / シグナル伝達 / レセプター / 転写因子 / Transcription factor / 細胞周期 / 分子生物学 / NF-AT / Signal transduction / DNA複製 … More / GM-CSFレセプター / 遺伝子発現 / 発現クロ-ニング / 情報伝達 / 造血因子 / initiation of DNA replication / ES Cells / Cdc7 kinase / G1-S transition / チェックポイント制御 / DNAヘリカーゼ / リン酸化 / スレオニンキナーゼ / セリン / MCMタンパク質 / S移行 / G1 / DNA複製開始 / ノックアウトマウス / DNA複製起点 / マウス胚性幹細胞 / サイクリン依存性キナーゼ / MCM2 / Cdc7キナーゼ / GATA-3 / NFAT / T細胞サブセット / JAK2 / STAT / Cell cycle / signal transduction / GM-CSF / トランスジェニックマウス / GM-CSF receptor / チロシンリン酸化 / Cytokine / 増殖因子 / IL-3 / 遺伝子導入 / サイトカインレセプター / インターロイキン / NF-KB / IL-3レセプター / T細胞 / 受容体 / レセプタ- / コロニ-刺激因子 / インタ-ロイキン / cytokine cluster region / cell cycle / Cdk / replication origins / サイトカイン遺伝子領域 / サイトカイン依存性キナーゼ / Cdcキナーゼ / phosphorylation / MCM / CDK / 減数分裂 / サイクリン / GI / キナーゼ / Chromatin structure / Nuclear translocation / Transcription factors / Helper T cell subsets / Cytokines / T lymphocytes / NF-κB / DNaseI hypersensitive site / 染色体構造制御 / 核移行 / Immune response / 免疫応答 / GM-CSF受容体 / JAK / 免疫反応 / T cell activation / Growth factor receptor / chrmosomal replication / Growth factor / T細胞活性化 / 増殖因子受容体 / 染色体複製 / konck-out mouse / tyrosine phosphorylation / protein kinases / interleukins / receptors / cytolines / hemotopoietic stem cells / 転写調節 / チロシンキナーゼ / 細胞増殖・分化 / プロティンキナーゼ / プロテインキナーゼ / 遺伝子破壊マウス / プロテイン キナーゼ / 造血幹細胞 / proliferation / differentiation / hematopoietic cell / transgenic mice / receptor expression / Cytokine receptor / EBNA / E2 / E1 / 複製 / EBV / BPV / ポリオーマ / エピソームベクター / ステムセル / 幹細胞 / エピゾーム / コロニー形成法 / 造血細胞 / 増殖 / 分化 / 血球細胞 / レセプター発現 / Early response genes / Gene transfer / Tyrosine phosphorylation / Transactivator / IL-3 receptor / トランスアクチベーター / 初期応答遺伝子 / トランスアクチベータ- / Receptor / kinase / primosome / G-protein / DNA replication / キナ-ゼ / プライモソ-ム / Gタンパク質 / Id / 6M-CSF / LIF / ES(胚幹)細胞 / GTP結合蛋白質 / 脂質メディエーター / 細胞機能発現 / 生理活性分子 / 細胞接着分子 / 細胞内シグナル伝達 / 細胞増殖 / 発現クローニング / コロニー刺激因子 / HTLV-Tax / IL-5遺伝子 … More
Except Principal Investigator
シグナル伝達 / サイトカイン / GM-CSF / ADF / 造血支持細胞 / 造血因子 / 造血幹細胞 / G1 / TCR / HLA / 造血因子レセプター / 転写因子 / cAMP / signal transduction / トランスジェニックマウス / 細胞死 / 遺伝子治療 / DNAヘリカーゼ / redox regulation / Thioredoxin / 細胞内情報伝達 / フレンド白血病 / 白血病細胞の分化 / RBタンパク / 試験管内DNA複製系 / International collabolation / Proteomics / Genomics / Asia-Pacific Molecular Biology Network / Asia and Pacific Rim region / Frontier Life Sciences / プロテオーム / ゲノム情報 / 国際共同研究 / プロテオミックス / ゲノミックス / 分子生物学ネットワーク(A-IMBN) / アジア環太平洋地域 / 先端生命科学 / Checkpoint cotrol / DNA helicase / phosphorylation / threonine kinase / Serine / MCM proteins / S transition / DNA rrplication / Cell cycle / DNAポリメラーゼ / チェックポイントコントロール / 不変製 起点 / キナーゼ / 細胞同期 / チェックポイント制御 / リン酸化 / スレオニンキナーゼ / セリン / MCMタンパク質 / S移行 / Gl / DNA複製 / 細胞周期 / signaling molecule / cytokine receptor / cytokine / gene therapy / adenoviral vectors / HeLa細胞 / プロモーター / LacZ / GM-CSFレセプター / T細胞 / サイトカイン・レセプター / シグナル伝達分子 / サイトカインレセプター / アデノウイルスベクター / Kno-ck-out mouse / Transcription factor / Impact factor / Hemoietic factor / Death signal / Differentiation signal / Hemopoietic stem / 造血幹細胞移植 / 造血微小環境 / チロシンキナーゼ / 造血幹細胞の精製 / 増殖の制御 / ノックアウト・マウス / 受容体チロシンキナーゼ / 分化制御 / Jak-Stat系 / 骨髄移植 / 増殖因子受容体 / 増殖因子 / シグナル伝進 / 遺伝子改変動物 / インパクトファクター / 造血調節因子 / 死のシグナル / 分化シグナル / Yeast replication origin / DNA replication-related proteins / Cadherin and cell adhesion / HGF and organ regeneration / Activin / IP3 receptor / Fas ligand / HGFと肝再生 / 細胞表面受容体 / 酵母複製開始点 / DNA複製関連遺伝子 / IP3レセプター / IL3 / カドヘリンと細胞接着 / 酵母染色体複製開始 / DNA複製関連蛋白質 / ガドヘリンと細胞接着 / HGFと器官再生 / アクチビン / IP_3レセプター / Fasリガンド / proteosome / prosessing / antigenic peptide / T細胞レパトワ / ペプチド / 免疫制御 / プロテオゾーム / アポトーシス / γδ型T細胞 / プロテアゾーム / プロセッシング / 抗原ペプチド / 造血器疾患 / SCF / c-kit / 研究まとめ / C-Kit / DNA binding protein / T cell activation signal / gene expression / cis-regulatory element / colony stimulating factor / interleukin 5 / interleukin 3 / トランスアクチベ-タ- / エンハンサ-配列 / コロニ-刺激因子 / インタ-ロイキン3 / トランスアクチベーター / エンハンサー配列 / DNA結合タンパク質 / DNA結合蛋白質 / T細胞活性化シグナル / 遺伝子発現 / シス調節領域 / コロニー刺激因子 / インターロイキン5 / インターロイキン3 / oxygen stress / cell activation / transcriptional factor / NFkappaB / thioredoxin / Oxygen stress / NFκB / Redox regulation / Oxygen Stress / 細胞活性化 / 転写調節因子 / NFKB / redox regnlation / スーパーオキサイドセンサー / 情報スウィチ蛋白質 / 金属リセプター / 金属タンパク質 / スーパーオキシサイドセンサー / NOセンサー / O_2センサー / COセンサー / 情報スイッチ蛋白質 / 情報伝達金属タンパク質 / 余属リセプター / 金属タンパク / Liptomycin B / 血球細胞 / 核輸送 / STAT5 / コロニーアッセイ / 有効活用方策の提案 / 産学共同研究 / 発明の帰属 / 特許 / 社会還元 / 積極的な対応 / 信頼関係の回復 / 企業のヒアリング / 大学における特許 / 産学連携 / レセプター / リンパ球分化 / トランスジェニック / レトロウイルス疾患 / 情報伝達 / 発癌 / 酸化ストレス / チオレドキシン / レドックス / 倫理審査 / 遺伝子治療・臨床プロトコール / 単一遺伝子病 / 白血病 / 悪性リンパ腫 / 固形がん / 難治性疾患 / DNA修復 / 色素性乾皮症 / T抗原 / DNAポリメラーゼα / SV40DNA / 転写活性因子 / NFーkB / EBV / HTLVー1 / TRX / ウイルス疾患 / 慢性関節リウマチ / ATL / HAM / HTLV-I / 免疫細胞活性化 / ウィルス疾患 / c‐kit / 造血因子レセプタ- / 特異的阻害剤 / 分子薬理学 / タンパク質リン酸化反応 / カルシウム信号 / バイオモジュレ-タ- / DNAアフィニティカラム / ヌクレオソ-ム / 2 / CDC28 / HBVXタンパク / 自律増殖配列 / cーmycタンパク Less
  • Research Projects

    (38 results)
  • Co-Researchers

    (119 People)
  •  サイトカインによるSTATの核・細胞質輸送機構制御の研究

    • Principal Investigator
      渡辺 すみ子
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  金属が関与するセンサーとスイッチのケミカルバイオロジー

    • Principal Investigator
      西野 武士
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nippon Medical School
  •  Development of frontier life science research for prevention and therapy of endemic diseases in Asia and the Pacific Rim Region

    • Principal Investigator
      KOIKE Katsuro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Special Purposes
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Joint study on DNA replication and checkpoint controlPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi, 正井 久雄
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  サイトカインレセプターとその変異体遺伝子導入マウス作製とその血液学的解析

    • Principal Investigator
      渡辺 すみ子
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Studies on regulation of mitotic DNA replication and meiosis by novel Cdc7-related kinase complexesPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi, 正井 久雄
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  特許など知的所有権の大学における現状およびその有効活用法に関する総合的研究

    • Principal Investigator
      安井 至
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Institution
      The University of Tokyo
  •  Joint study on activation of eukaryotic replication origins

    • Principal Investigator
      MASAI Hisao
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  hGM-CSFレセプタートランスジェニックマウスを用いたリンパ球分化の解析

    • Principal Investigator
      渡辺 すみ子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Analyses of cytokine gene expression by helper T cell subsets : role of NFAT-mediated gene activation and subset-specific regulatory mechanism.Principal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  レドックスによる情報伝達と病態制御に関する総合的研究

    • Principal Investigator
      淀井 淳司
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Kyoto University
  •  Joint study on regulation of cell profferation by cytokinesPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Structural biochemistry
    • Research Institution
      University of Tokyo
  •  Generation of disease model mice by the alteration of transcription factors regulating immune responsesPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      The University of Tokyo
  •  難治性疾患に対する遺伝子治療の臨床への展開

    • Principal Investigator
      浅野 茂隆
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Signal transduction via receptors for hemopoietic rrouwth factorsPrincipal Investigator

    • Principal Investigator
      ARAO Ken-ichi
    • Project Period (FY)
      1994 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Regulation of Hemopoietic Stem Cells and Its Clinical Application

    • Principal Investigator
      KITAMURA Yukihiko
    • Project Period (FY)
      1994 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Study of mechanism of action of cytokines and signaling molecules using adenoviral transient expression vectors

    • Principal Investigator
      YOKOTA Takashi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  サイトカインによる細胞の増殖,分化の制御とシグナル伝達Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  サイトカインと細胞接着分子による細胞内シグナル伝達ネットワークの研究Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Cell biology
    • Research Institution
      The University of Tokyo
  •  遺伝子導入ES細胞を用いたマウス胚初期発生におけるサイトカインの役割の研究Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  Molecular mechanisms of immune regulation.

    • Principal Investigator
      SASAZUKI Takehiko
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Cell Growth Switch and Formation of Higher Organization and Function

    • Principal Investigator
      KOIKE Katsuro
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Cell biology
    • Research Institution
      THE CANCER INSTITUTE (JFCR)
  •  DNA複製反応の促進及び抑制のメカニズムと癌化

    • Principal Investigator
      吉田 松年
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  サイトカインによる細胞の増殖.分化の制御とシグナル伝達Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  造血因子の構造と作用の分子生物学的検討と生体内作用Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Regulation of IL-3 and GM-CSF genes and their receptorsPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  造血幹細胞の分化増殖の分子生物学的解析

    • Principal Investigator
      三浦 恭定
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Development of high-level expression vectors in embryonic and hematopoietic stem cells and generati of GM-CSF and IL-3 of receptor transgenic micePrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      The University of Tokyo
  •  サイトカインによる細胞の増殖分化の制御とシグナル伝達Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  造血因子の構造と作用の分子生物学的検討と生体内作用Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  造血幹細胞の分化増殖の分子生物学的解析

    • Principal Investigator
      MIUA Yasusada
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  ウィルス疾患における免疫細胞活性化異常に関する総合研究

    • Principal Investigator
      YODAI Junji
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University
  •  Studies on activation mechanism in the viral diseases

    • Principal Investigator
      YODAI Junji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute For Virus Research, Kyoto University
  •  Signal transduction of T cell activation and regulation of IL-3 and GM-CSF gene expression

    • Principal Investigator
      YOKOTA Takashi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      The University of Tokyo
  •  DNA複製反応の促進及び抑制のメカニズムと癌化

    • Principal Investigator
      吉田 松年
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  造血因子の構造と作用の分子生物学的検討と生体内作用Principal Investigator

    • Principal Investigator
      新井 賢一
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  バイオモジュレ-タ-による蛋白質リン酸化反応の制御

    • Principal Investigator
      日高 弘義
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      物質生物化学
    • Research Institution
      Nagoya University
  •  Gene expression and DNA replication triggered by growth factors and their receptorsPrincipal Investigator

    • Principal Investigator
      ARAI Ken-ichi
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      代謝生物化学
    • Research Institution
      The University of Tokyo
  • 1.  WATANABE Sumiko (60240735)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  MASAI Hisao (40229349)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 3.  YOKOTA Takashi (50134622)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 4.  MURAMATSU Masa-aki (50230008)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  NAGATA Shigekazu (70114428)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  SATO Noriko (70280956)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 7.  平野 俊夫 (40136718)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 8.  KOIKE Katsuro (30085625)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  TAKATSU Kiyoshi (10107055)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 10.  高久 史麿 (40048955)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 11.  NAKAYAMA Naoki (80227967)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 12.  INOUE Tohru (50100110)
    # of Collaborated Projects: 3 results
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  • 32.  DE VRIES Jan
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  • 33.  JAN de Vries
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  • 37.  YOSHIKAI Yasunobu (90158402)
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  • 94.  PATUICK A. Baenerle
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  • 100.  リチャード クラウスナー
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  • 102.  中川 菜峰子
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  • 103.  WOLFRAM Oste
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  • 104.  KOYANO Naoko
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  • 106.  OSTERTAG Wol
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  • 107.  SHLOMAI Jose
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  • 108.  JOSEPH Sholomai
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  • 109.  JOSEPH Shlom
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  • 110.  YSSEL Hans
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  • 111.  MUI Alice
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  • 112.  BOLLEN Josep
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  • 113.  LEES Emma
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  • 114.  MASUDA Esteb
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    # of Collaborated Products: 0 results
  • 115.  SHOMAI Josep
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    # of Collaborated Products: 0 results
  • 116.  TERESE Wang
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    # of Collaborated Products: 0 results
  • 117.  PAUL Russell
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    # of Collaborated Products: 0 results
  • 118.  RUSSEL Paul
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 119.  GIACCA Mauro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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