Dohmae Naoshi 堂前直

… Alternative Names

DOHMAE Naoshi 堂前直

堂前直ドウマエナオシ

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Researcher Number	00321787
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 部門長代理
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副部門長 2016 – 2020: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2017: 国立研究開発法人理化学研究所, その他, 研究員 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2014: 独立行政法人理化学研究所, その他部局等, 研究員 2014: 理化学研究所, 環境資源科学研究センター, ユニットリーダー 2005: 独立行政法人理化学研究所, バイオ解析チーム, チームリーダー
Review Section/Research Field	Principal Investigator Structural biochemistry Except Principal Investigator Basic Section 38030:Applied biochemistry-related / Basic Section 53040:Nephrology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56030:Urology-related / Basic Section 55020:Digestive surgery-related / Basic Section 38040:Bioorganic chemistry-related / Basic Section 54010:Hematology and medical oncology-related / General internal medicine(including psychosomatic medicine) / Molecular biology / Naval and maritime engineering / Bio-related chemistry / Applied microbiology
Keywords	Principal Investigator 定量法 / ウエスタンブロット / 加水分解 / 糖鎖 / リン酸化 / AQC / アミノ酸分析 / 翻訳後修飾 Except Principal Investigator 翻訳後修飾 / サイトカイン … More / 質量分析 / Hippo経路 / TEAD / タンパク質 / 近接依存性標識法 / シナプス機能 / プレセニリン / シナプス / アルツハイマー病 / 治療抵抗性 / 食事 / 泌尿器癌 / PI3K / 腫瘍微少環境 / 飽和脂肪酸 / 腫瘍免疫 / 癌進展 / 多価不飽和脂肪酸 / LPS / 腸内細菌 / 高脂肪 / 高脂肪食 / 腎癌 / 前立腺癌 / 腸内細菌叢 / 肥満 / グライコミクス解析 / ホルマリン固定標本 / 悪性化 / 腹膜偽粘液腫 / 好酸球性多発血管炎性肉芽腫症 / inhibitor / targget identification / proteome analysis / chemical biology / リジン脱アセチル化酵素 / アシルCoA / 脂質代謝 / アシルCoA合成酵素 / リジン長鎖アシル化 / 分子探索・プロファイリング / 分子プロファイリング / 生理機能解析 / 病理形態解析 / ゲノム編集 / モデル動物作製 / calreticulin / サイトカイン受容体 / 分子シャペロン / Calreticulin / 骨髄増殖性腫瘍 / アシローム / KDAC / YAP / TAZ / リジンアシル化 / 自己抗体 / 続発性 / 特発性 / 糸球体 / 抗原 / Bucillamine腎症 / PLA2R陰性 / PLA2R陽性 / 膜性腎症 / 五苓散 / 炎症制御 / 漢方薬 / 腎炎 / HMGB1 / 蛋白質 / 癌 / アシル化 / 脂質修飾 / がん / パルミトイル化 / ミリストイル化 / タンパク質定量 / 塗料の防汚性能 / 生物付着 / アミノ酸組成分析 / 亜酸化銅 / 防汚塗料 / アミノ酸 / 加水分解 / 固体酸触媒 / 翻訳後修飾アミノ酸 / 2次元クロマトグラフィー / アミノ酸分析 / 翻訳伸長因子 / バクテリア / スクシニル化 / リジンアセチル化 / SILAC / 枯草菌 / EFTu / 翻訳制御 / タンパク質スクシニル化 / タンパク質アセチル化 Less

Elucidation of novel regulation of lipid metabolism by lysine lipid modifications and its control
- Principal Investigator
  
  伊藤昭博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
MSベースのプロテオームプロファイリングに基づく薬剤標的解析システムの構築
- Principal Investigator
  
  室井誠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Institute of Physical and Chemical Research
好酸球細胞外トラップの腎尿細管間質障害メカニズムの探索
- Principal Investigator
  
  齋藤雅也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Akita University
Identification of mechanism of malignant transformation and characteristics of mucin in pseudomyxoma peritonei using multiomics-analysis
- Principal Investigator
  
  野口玲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  National Cancer Center Japan
先端モデル動物支援プラットフォーム
- Principal Investigator
  
  武川睦寛
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  The University of Tokyo
シナプス活動変容からアプローチするアルツハイマー病発症機序の解明
- Principal Investigator
  
  渡部博貴
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Keio University
Elucidation of receptor maturation mechanism that causes myeloproliferative neoplasms
- Principal Investigator
  
  Masubuchi Nami
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Molecular mechanisms and target molecules associated with progression and treatment resistance of urologic cancers associated with microbiome alterations by diet and obesity
- Principal Investigator
  
  羽渕友則
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Akita University
The study to identify novel pathogenesis and autoantigens in patients with membranous nephropathy
- Principal Investigator
  
  Komatsuda Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Akita University
Elucidation of cell regulatory mechanism by lysine long-chain fatty modifications
- Principal Investigator
  
  Ito Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Study on evaluation method for antifouling by development of micro quantitative analysis for organisms attached to ship
- Principal Investigator
  
  Masuda Akiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Naval and maritime engineering
- Research Institution
  National Institute of Maritime, Port and Aviation Technology
Can Kampo Medicines treat chronic kidney disease? : Challenge to elucidate the inflammation control mechanism of traditional herbal medicine
- Principal Investigator
  
  OYAMA Yoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kagoshima University
Identification and functional analyses of lysine long chain fatty acylated proteins
- Principal Investigator
  
  Ito Akihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Institute of Physical and Chemical Research
Quantification of post-translational modified amino acids by 2D-HPLC and ultra-sensitive amino acid analysis
- Principal Investigator
  
  Masuda Akiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  National Institute of Maritime, Port and Aviation Technology
Study on the role of protein acetylation in translational regulation in bacteria
- Principal Investigator
  
  KOSONO Saori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
ウエスタンブロットによる膜上タンパク質試料からの翻訳後修飾解析法の開発Principal Investigator
- Principal Investigator
  
  堂前直
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2019 2018 2017 2016 2014

All Journal Article Presentation

[Journal Article] Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling2023
- Author(s)
  KAWATANI MAKOTO、AONO HARUMI、HIRANUMA SAYOKO、SHIMIZU TAKESHI、MUROI MAKOTO、NOGAWA TOSHIHIKO、OHISHI TOMOKAZU、OHBA SHUN-ICHI、KAWADA MANABU、YAMAZAKI KANAMI、DAN SHINGO、DOHMAE NAOSHI、OSADA HIROYUKI
- Journal Title
  
  Oncology Research
  
  Volume: 31 Issue: 6 Pages: 833-844
- DOI
  10.32604/or.2023.030241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-22K06783, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04720
[Journal Article] METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance2022
- Author(s)
  Matsuura-Suzuki Eriko、Shimazu Tadahiro、Takahashi Mari、Kotoshiba Kaoru、Suzuki Takehiro、Kashiwagi Kazuhiro、Sohtome Yoshihiro、Akakabe Mai、Sodeoka Mikiko、Dohmae Naoshi、Ito Takuhiro、Shinkai Yoichi、Iwasaki Shintaro
- Journal Title
  
  eLife
  
  Volume: 11 Pages: 1-33
- DOI
  10.7554/elife.72780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05281, KAKENHI-PLANNED-22H05019, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K06497, KAKENHI-PROJECT-21K06026, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-23K23481, KAKENHI-ORGANIZER-22H05017
[Journal Article] Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors2022
- Author(s)
  Fang Qi、Kimura Yusuke、Shimazu Tadahiro、Suzuki Takehiro、Yamada Ayumi、Dohmae Naoshi、Iwasaki Shintaro、Shinkai Yoichi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 4104-4104
- DOI
  10.1038/s41598-022-08061-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-18H03991, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19K22406
[Journal Article] アミノ酸分析の膜タンパク質構造解析への応用2016
- Author(s)
  堂前直
- Journal Title
  
  アミノ酸研究
  
  Volume: 10 Pages: 67-69
- Data Source
  KAKENHI-PROJECT-26410190
[Journal Article] Structural basis for amino-acid export by DMT superfamily transporter YddG2016
- Author(s)
  H. Tsuchiya, S. Doki, M. Takemoto, T. Ikuta, T. Higuchi, K. Fukui, Y. Usuda, E. Tabuchi, S. Nagatoishi, K. Tsumoto, T. Nishizawa, K. Ito, N. Dohmae, R. Ishitani and O. Nureki
- Journal Title
  
  Nature
  
  Volume: 534 Issue: 7607 Pages: 417-420
- DOI
  10.1038/nature17991
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24227004, KAKENHI-PROJECT-16H04710, KAKENHI-PROJECT-15J08129, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-26410190, KAKENHI-PROJECT-15K17882, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-16H02420
[Journal Article] Neisseria meningitidis Translation Elongation Factor P and Its Active-Site Arginine Residue Are Essential for Cell Viability2016
- Author(s)
  Yanagisawa T, Takahashi H, Suzuki T, Masuda A, Dohmae N, Yokoyama S.
- Journal Title
  
  PLoS ONE
  
  Volume: 11(2) Issue: 2 Pages: e0147907-e0147907
- DOI
  10.1371/journal.pone.0147907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26410190, KAKENHI-PROJECT-15K08485
[Presentation] 新規DHODH阻害剤NPD723の作用機構と構造活性相関2023
- Author(s)
  川谷誠、青野晴美、平沼佐代子、清水猛、室井誠、野川俊彦、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、堂前直、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22H04922
[Presentation] 新規DHODH阻害剤NPD723の構造活性相関解析2023
- Author(s)
  川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、堂前直、長田裕之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22H04922
[Presentation] 転写因子TEADの転写活性を制御する新規翻訳後修飾リジン長鎖アシル化の解析2021
- Author(s)
  則次恒太、堂前直、吉田稔、伊藤昭博
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] Characterization of Glomerular Proteins in Primary and Bucillamine-induced Membranous Nephropathy2021
- Author(s)
  加賀一、小松田敦、涌井秀樹、堂前直
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-19K08694
[Presentation] The role of lysine long-chain fatty acylation of TEAD transcription factors for transcriptional output of Hippo signaling pathway2019
- Author(s)
  Kota Noritsugu, Kenji Ogawa, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito
- Organizer
  FASEB Science Research Conference: Reversible Protein Acetylation in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] 船体付着生物の微量定量分析法開発と防汚塗料の防汚性能評価2019
- Author(s)
  益田晶子、安藤裕友、堂前直
- Organizer
  日本マリンエンジニアリング学会
- Data Source
  KAKENHI-PROJECT-17K06972
[Presentation] Comprehensive screening for lysine long-chain fatty acyl proteins2019
- Author(s)
  Akihiro Ito, Ryu Kato, Kota Noritsugu, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida
- Organizer
  FASEB Science Research Conference: Reversible Protein Acetylation in Health and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン鎖アシル化タンパク質の網羅的な探索法の開発2019
- Author(s)
  加藤竜、則次恒太、鈴木健裕、堂前直、吉田稔、伊藤昭博
- Organizer
  第24 回化学生物学研究会
- Data Source
  KAKENHI-PROJECT-19H02890
[Presentation] リジン長鎖アシル化修飾による転写因子TEADの活性制御機構の解析2018
- Author(s)
  則次恒太、伊藤昭博、小川健司、鈴木健裕、堂前直、吉田稔
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] アミノ酸分析法を用いた船体付着生物の定量2018
- Author(s)
  益田晶子、堂前直、安藤裕友
- Organizer
  日本アミノ酸学会第12回学術大会
- Data Source
  KAKENHI-PROJECT-17K06972
[Presentation] 転写因子TEADのリジン長鎖アシル化修飾制御機構とその機能の解析2017
- Author(s)
  則次恒太、伊藤昭博、小川健司、鈴木健裕、堂前直、吉田稔
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] 新規リジン長鎖アシル化タンパク質TEADの機能解析2017
- Author(s)
  則次恒太、伊藤昭博、工藤紀雄、鈴木健裕、堂前直、吉田稔
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] Long chain fatty acyl lysine modification of TEAD transcription factors2017
- Author(s)
  Akihiro Ito, Kota Noritsugu, Takehiro Suzuki, Naoshi Dohmae, Minoru Yoshida
- Organizer
  FASEB Science Research Conference「Reversible Acetylation on Health and Disease (HDACs)」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14674
[Presentation] ヒストンリジン残基の水酸化修飾の発見とDNA メチル化に関与する新しい因子の発見2016
- Author(s)
  鵜木元香、益田晶子、堂前直、中村祐輔、佐々木裕之
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-26410190
[Presentation] 自動・迅速アミノ酸分析を可能にする固体酸触媒をもちいた加水分解方法の検討2014
- Author(s)
  益田晶子、堂前直
- Organizer
  日本分析化学会第６３年会
- Place of Presentation
  広島
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-26410190
[Presentation] 固体酸触媒を利用したタンパク質加水分解2014
- Author(s)
  堂前直、益田晶子
- Organizer
  第4回日本アミノ酸学会・産官学連携シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-06-16
- Data Source
  KAKENHI-PROJECT-26410190

1. Ito Akihiro (40391859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. Masuda Akiko (10322679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. どど孝介 (20415243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOSONO Saori (90321760)

# of Collaborated Projects: 1 results

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5. OYAMA Yoko (20583470)

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6. Komatsuda Atsushi (70272044)

# of Collaborated Projects: 1 results

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7. Masubuchi Nami (00791641)

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8. 安藤裕友 (70462869)

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9. 丸山征郎 (20082282)

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# of Collaborated Projects: 1 results

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35. 宮崎龍彦 (80239384)

# of Collaborated Projects: 1 results

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36. 高松学 (00750366)

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37. 宮川剛 (10301780)

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39. 池田和隆 (60281656)

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40. 井手聡一郎 (30389118)

# of Collaborated Projects: 1 results

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41. 新田淳美 (20275093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 尾藤晴彦 (00291964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 虫明元 (80219849)

# of Collaborated Projects: 1 results

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44. 小山内実 (90286419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 旦慎吾 (70332202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
46. 馬島哲夫 (30311228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 田代悦 (00365446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 松本健 (60222311)

# of Collaborated Projects: 1 results

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49. 川田学 (20300808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 掛谷秀昭 (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 澤崎達也 (50314969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 松浦正明 (40173794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 室井誠 (30261168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
55. 齋藤雅也 (00831215)

# of Collaborated Projects: 1 results

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56. 野口玲 (30779682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. 竹村しづき (20420391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. 羽渕友則 (00293861)

# of Collaborated Projects: 1 results

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59. 嘉島相輝 (50842952)

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60. 南條博 (70250892)

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66. 掛川渉 (70383718)

# of Collaborated Projects: 1 results

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67. ITO Takuhiro

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# of Collaborated Products: 1 results
68. 伊藤耕一

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# of Collaborated Products: 1 results
69. 濡木理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 真貝洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Dohmae Naoshi 堂前 直

DOHMAE Naoshi 堂前 直

堂前 直 ドウマエ ナオシ

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Dohmae Naoshi 堂前直

DOHMAE Naoshi 堂前直

堂前直ドウマエナオシ