HIGUCHI MAKOTO 樋口真人

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HIGUCHI Makoto 樋口真人

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Researcher Number	10373359
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 教授 2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究センター, センター長 2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 部長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所脳機能イメージング研究部, 部長 2019 – 2021: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 部長(定常) 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 次長(定常) 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, チームリーダー 2016 – 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, チームリーダー(定常) … More 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー 2015: 国立研究開発法人放射線医学総合研究所, 分子神経イメージング研究プログラム, チームリーダー 2015: 放射線医学総合研究所, チームリーダー 2014: 独立行政法人放射線医学総合研究所, 分子神経イメージング研究プログラム, チームリーダー 2014: 独立行政法人放射線医学総合研究所分子神経イメージンググループ, グループリーダー 2006 – 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー 2010: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダ 2007: National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダー 2005: 独立行政法人放射線医学総合研究所, 脳機能イメージング研究開発推進室, リサーチフェロー Less
Review Section/Research Field	Principal Investigator Biological Sciences / Neurology / Neurophysiology / General neuroscience / Biological Sciences Except Principal Investigator Neurology / Radiation science / Basic Section 52030:Psychiatry-related / Medium-sized Section 57:Oral science and related fields / Biological Sciences / Cerebral neurosurgery / Psychiatric science
Keywords	Principal Investigator アルツハイマー病 / モデル動物 / イメージング / 認知症 / 神経科学 / 神経原線維変化 / 老人斑 / タウ蛋白 / アミロイドβペプチド / ポジトロン断層撮影 … More / 脳アミロイド / 神経炎症 / タウタンパク / 薬学 / 脳疾患研究 / 生体分子 / ミクログリア / 生体イメージング / 前頭側頭葉変性症 / 痴呆 / 薬理学 / 薬剤開発 / 診断薬開発 / オートファジー / アミロイドベータペプチド / 核磁気共鳴画像 / 光イメージング … More Except Principal Investigator PET / タウイメージング / アルツハイマー病 / 放射線 / 脳神経疾患 / 脳画像 / バイオマーカー / 進行性核上性麻痺 / PiB陰性認知症 / タウオパチー / アルツハイマー型認知症 / PBB3-PET / PiB-PET / タウPET / アミロイドPET陰性認知症 / 認知症 / 神経機能画像学 / 痴呆 / 神経科学 / 遅発性精神障害 / 予防 / 基礎ー前臨床研究 / ヒト / 脳病態イメージング / 歯の喪失 / イメージングバイオマーカー / 遅発性統合失調症 / 遅発性精神病 / タウ / 大脳皮質基底核症候群 / Alzheimer病 / 重症度評価 / 神経機能画像 / ドーパミン / 糖代謝 / 覚醒下 / グルコース代謝 / SPECT / 脳血流 / DREADD / アミロイド陰性認知症 / 解剖学 / 蛋白質 / 改造学 / 遺伝子 / 新規タウイメージグ / 皮質基底核変性症 / 神経原線維変化 / 若年性認知症 / 嗜銀顆粒性認知症 / アミロイドPET / 神経移植 / 光学計測 / 老化 / 鑑別診断 / レヴィ小体型認知症 / 薬学 / 遺伝子改変マウス / 脳・神経 / 核医学(PETを含む) / マウス / トランスレーショナルリサーチ / 脳 / 核医学 / 分子イメージング / 生理学 / ストレス / 精神薬理学 Less

イメージングバイオマーカーによる遅発性精神病性障害における新規神経病理の同定
- Principal Investigator
  
  高橋英彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Medical and Dental University
高齢者の歯の喪失はアルツハイマー病の起因となるか？脳幹におこる初期病変の解明
- Principal Investigator
  
  後藤多津子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tokyo Dental College
Stratification of late onset psychosis using imaging biomarkers
- Principal Investigator
  
  Takahashi Hidehiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Medical and Dental University
Evaluation of tau accumulation with PBB3-PET in amyloid negative dementia patients
- Principal Investigator
  
  Takeuchi Jun
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
Etiological assessments of neurodegenerative dementias by in-vivo imaging of pathological protein aggregates in the brainPrincipal Investigator
- Principal Investigator
  
  Higuchi Makoto
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
In vivo brain activity imaging in DREADD expressed animals
- Principal Investigator
  
  SEKI Chie
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Evaluation of tau accumulation with PBB3-PET in amyloid negative dementia patients
- Principal Investigator
  
  ATAKA Suzuka
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka City University
Tau PET study for revealing the pathogenesis and establishing the objective marker of disease severity in neurodegenerative dementia
- Principal Investigator
  
  Shimada Hitoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
In vivo PET and optical imaging of neurogenesis of neuronal circuit
- Principal Investigator
  
  INAJI Motoki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tokyo Medical and Dental University
Molecular imaging of neurotoxic signaling in neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  Higuchi Makoto
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
Development of ligands for early diagnosis and mechanistic controls of tauopathiesPrincipal Investigator
- Principal Investigator
  
  Higuchi Makoto
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  National Institute of Radiological Sciences
Relationship between cerebral perfusion/neuronal activity and amyloid deposition
- Principal Investigator
  
  SEKI Chie
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Brain Environment
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Developing a new diagnostic system using positron emission tomography for dementia with Lewy bodies
- Principal Investigator
  
  SHIMADA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Institute of Radiological Sciences
アミロイドカスケードのキープロセス可視化によるアルツハイマー病の診断・治療法開発Principal Investigator
- Principal Investigator
  
  樋口真人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling
- Principal Investigator
  
  KIMURA Yuichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Methodological development of quantitative tracer kinetic analysis in rodents using small animal PET.
- Principal Investigator
  
  SEKI Chie
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
The mechanism for fear learning concerning NMDA receptor NR2B subunit.
- Principal Investigator
  
  SHIN Ryong-moon
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  National Institute of Radiological Sciences
アミロイドとミクログリアの生体画像化による抗アミロイド療法の機構解明と評価法確立Principal Investigator
- Principal Investigator
  
  樋口真人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
新規化合物による脳アミロイド病変形成阻害効果の解析Principal Investigator
- Principal Investigator
  
  樋口真人
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Institute of Radiological Sciences

[Book] Annual Review 神経2014
- Author(s)
  島田斉、樋口真人
- Total Pages
  51
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23390235
[Journal Article] In vivo PET classification of tau pathologies in patients with frontotemporal dementia2024
- Author(s)
  Kubota Manabu、Endo Hironobu、Takahata Keisuke、Tagai Kenji、Suzuki Hisaomi、Onaya Mitsumoto、Sano Yasunori、Yamamoto Yasuharu、Kurose Shin、Matsuoka Kiwamu、Seki Chie、Shinotoh Hitoshi、Kawamura Kazunori、Zhang Ming-Rong、Takado Yuhei、Shimada Hitoshi、Higuchi Makoto
- Journal Title
  
  Brain Communications
  
  Volume: 6 Issue: 2
- DOI
  10.1093/braincomms/fcae075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-23K24259
[Journal Article] Investigating neural dysfunction with abnormal protein deposition in Alzheimer’s disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography2024
- Author(s)
  Matsuoka Kiwamu、Hirata Kosei、Kokubo Naomi、Maeda Takamasa、Tagai Kenji、Endo Hironobu、Takahata Keisuke、Shinotoh Hitoshi、Ono Maiko、Seki Chie、Tatebe Harutsugu、Kawamura Kazunori、Zhang Ming-Rong、Shimada Hitoshi、Tokuda Takahiko、Higuchi Makoto、Takado Yuhei
- Journal Title
  
  NeuroImage: Clinical
  
  Volume: 41 Pages: 103560-103560
- DOI
  10.1016/j.nicl.2023.103560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K19393, KAKENHI-PROJECT-20K16681
[Journal Article] Association of Tooth Loss with Alzheimer’s Disease Tau Pathologies Assessed by Positron Emission Tomography2023
- Author(s)
  Matsumoto Hideki、Tagai Kenji、Endo Hironobu、Matsuoka Kiwamu、Takado Yuhei、Kokubo Naomi、Shimada Hitoshi、Goto Tetsuya、Goto Tazuko K.、Higuchi Makoto
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 96 Issue: 3 Pages: 1253-1265
- DOI
  10.3233/jad-230581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K15776
[Journal Article] Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy2023
- Author(s)
  Matsuoka Kiwamu、Takado Yuhei、Tagai Kenji、Kubota Manabu、Sano Yasunori、Takahata Keisuke、Ono Maiko、Seki Chie、Matsumoto Hideki、Endo Hironobu、Shinotoh Hitoshi、Sahara Yasuka、Obata Takayuki、Near Jamie、Kawamura Kazunori、Zhang Ming-Rong、Suhara Tetsuya、Shimada Hitoshi、Higuchi Makoto
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 444 Pages: 120514-120514
- DOI
  10.1016/j.jns.2022.120514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935, KAKENHI-PROJECT-20K16681, KAKENHI-PROJECT-23K24259
[Journal Article] An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607)2022
- Author(s)
  Tagai Kenji、Ikoma Yoko、Endo Hironobu、Debnath Oiendrila Bhowmik、Seki Chie、Matsuoka Kiwamu、Matsumoto Hideki、Oya Masaki、Hirata Kosei、Shinotoh Hitoshi、Takahata Keisuke、Kurose Shin、Sano Yasunori、Ono Maiko、Shimada Hitoshi、Kawamura Kazunori、Zhang Ming-Rong、Takado Yuhei、Higuchi Makoto
- Journal Title
  
  NeuroImage
  
  Volume: 264 Pages: 119763-119763
- DOI
  10.1016/j.neuroimage.2022.119763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K15776, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935
[Journal Article] A Machine Learning-Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images2022
- Author(s)
  Endo Hironobu、Tagai Kenji、Ono Maiko、Ikoma Yoko、Oyama Asaka、Matsuoka Kiwamu、Kokubo Naomi、Hirata Kosei et al.
- Journal Title
  
  Movement Disorders
  
  Volume: 37 Issue: 11 Pages: 2236-2246
- DOI
  10.1002/mds.29173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-21K15705, KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-20K07935
[Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies2021
- Author(s)
  Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, (24人省略), Shimada H.
- Journal Title
  
  Neuron
  
  Volume: 109 Issue: 1 Pages: 42-58
- DOI
  10.1016/j.neuron.2020.09.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07543, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K06929, KAKENHI-PROJECT-19K17101, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H03362, KAKENHI-PROJECT-19H03583
[Journal Article] Relationship between regional gray matter volumes and dopamine D2 receptor and transporter in living human brains2021
- Author(s)
  Kurose Shin、Kubota Manabu、Takahata Keisuke、Yamamoto Yasuharu、Fujiwara Hironobu、Kimura Yasuyuki、Ito Hiroshi、Takeuchi Hiroyoshi、Mimura Masaru、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Human Brain Mapping
  
  Volume: - Issue: 12 Pages: 4048-4058
- DOI
  10.1002/hbm.25538
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17071, KAKENHI-PROJECT-19H03583, KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-19K17101
[Journal Article] Comparison of MRI-based and PET-based image pre-processing for quantification of 11C-PBB3 uptake in human brain2021
- Author(s)
  Yousefzadeh-Nowshahr Elham、Winter Gordon、Bohn Peter、Kneer Katharina、von Arnim Christine A.F.、Otto Markus、Solbach Christoph、Anderl-Straub Sarah、Polivka D?rte、Fissler Patrick、Prasad Vikas、Kletting Peter、Riepe Matthias W.、Higuchi Makoto、Ludolph Albert、Beer Ambros J.、Glatting Gerhard
- Journal Title
  
  Zeitschrift f?r Medizinische Physik
  
  Volume: 31 Issue: 1 Pages: 37-47
- DOI
  10.1016/j.zemedi.2020.12.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583
[Journal Article] Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-16072021
- Author(s)
  Shi Yang、Murzin Alexey G.、Falcon Benjamin、Epstein Alexander、Machin Jonathan、Tempest Paul、Newell Kathy L.、Vidal Ruben、Garringer Holly J.、Sahara Naruhiko、Higuchi Makoto、Ghetti Bernardino、Jang Ming-Kuei、Scheres Sjors H. W.、Goedert Michel
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 141 Issue: 5 Pages: 697-708
- DOI
  10.1007/s00401-021-02294-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19H03583
[Journal Article] Excess tau PET ligand retention in elderly patients with major depressive disorder2020
- Author(s)
  Moriguchi Sho、Takahata Keisuke、Shimada Hitoshi、Kubota Manabu、Kitamura Soichiro、Kimura Yasuyuki、Tagai Kenji、Tarumi Ryosuke、Tabuchi Hajime、Meyer Jeffrey H.、Mimura Masaru、Kawamura Kazunori、Zhang Ming-Rong、Murayama Shigeo、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Molecular Psychiatry
  
  Volume: Online ahead of print Issue: 10 Pages: 5856-5863
- DOI
  10.1038/s41380-020-0766-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583, KAKENHI-PROJECT-20H03606
[Journal Article] Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [ 18 F]PM‐PBB3 for clinical applications2020
- Author(s)
  Kawamura Kazunori、Hashimoto Hiroki、Furutsuka Kenji、Ohkubo Takayuki、Fujishiro Tomoya、Togashi Takahiro、Arashi Daisuke、Sakai Toshiyuki、Muto Masatoshi、Ogawa Masanao、Kurihara Yusuke、Nengaki Nobuki、Takei Makoto、Nemoto Kazuyoshi、Higuchi Makoto、Zhang Ming‐Rong
- Journal Title
  
  Journal of Labelled Compounds and Radiopharmaceuticals
  
  Volume: 64 Issue: 3 Pages: 109-119
- DOI
  10.1002/jlcr.3890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03583
[Journal Article] Excess tau PET ligand retention in elderly patients with major depressive disorder: a PET study2020
- Author(s)
  Moriguchi Sho、（14名略）、Higuchi Makoto
- Journal Title
  
  Molecular Psychiatry
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Journal Article] Visualization of AMPA receptors in living human brain with positron emission tomography.2020
- Author(s)
  Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Mimura M, Yuzaki M, Kato H, Higuchi M, Uchida H, Takahashi T.
- Journal Title
  
  Nature Medicine
  
  Volume: 26 Issue: 2 Pages: 281-288
- DOI
  10.1038/s41591-019-0723-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06461, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-20KK0193, KAKENHI-PROJECT-18H02755
[Journal Article] Deschloroclozapine: a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys2020
- Author(s)
  Nagai Yuji、（25名略）、Higuchi Makoto、Jian Jin、Bryan L. Roth、Minamimoto Takafumi
- Journal Title
  
  Nature Neuroscience
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation2019
- Author(s)
  Saito Takashi、Mihira Naomi、Matsuba Yukio、Sasaguri Hiroki、Hashimoto Shoko、Narasimhan Sneha、Zhang Bin、Murayama Shigeo、Higuchi Makoto、Lee Virginia M. Y.、Trojanowski John Q.、Saido Takaomi C.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 34 Pages: 12754-12765
- DOI
  10.1074/jbc.ra119.009487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] Clinical heterogeneity of frontotemporal dementia and Parkinsonism linked to chromosome 17 caused by MAPT N279K mutation in relation to tau positron emission tomography features2019
- Author(s)
  Ikeda Aya、Shimada Hitoshi、Nishioka Kenya、Takanashi Masashi、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Funayama Manabu、Ueno Yuji、Hatano Taku、Sahara Naruhiko、Suhara Tetsuya、Higuchi Makoto、Hattori Nobutaka
- Journal Title
  
  Movement Disorders
  
  Volume: 34 Issue: 4 Pages: 568-574
- DOI
  10.1002/mds.27623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-19K08003, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-18H04043
[Journal Article] Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results.2019
- Author(s)
  Takenoshita N, Shimizu S, Kanetaka H, Sakurai H, Suzuki R, Miwa T, Odawara M, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 71 Issue: 1 Pages: 261-271
- DOI
  10.3233/jad-190620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07479, KAKENHI-PROJECT-19K07898, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K09813
[Journal Article] In vivo binding of a tau imaging probe, [ 11 C]PBB3, in patients with progressive supranuclear palsy2019
- Author(s)
  Endo Hironobu、Shimada Hitoshi、Sahara Naruhiko、Ono Maiko、Koga Shunsuke、Kitamura Soichiro、Niwa Fumitoshi、Hirano Shigeki、Kimura Yasuyuki、Ichise Masanori、Shinotoh Hitoshi、Zhang Ming Rong、Kuwabara Satoshi、Dickson Dennis W.、Toda Tatsushi、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Movement Disorders
  
  Volume: 34 Issue: 5 Pages: 744-754
- DOI
  10.1002/mds.27643
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437
[Journal Article] Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes2019
- Author(s)
  Takeuchi Jun、Kikukawa Takayuki、Saito Haruna、Hasegawa Itsuki、Takeda Akitoshi、Hatsuta Hiroyuki、Kawabe Joji、Wada Yasuhiro、Mawatari Aya、Igesaka Ami、Doi Hisashi、Watanabe Yasuyoshi、Shimada Hitoshi、Kitamura Soichiro、Higuchi Makoto、Suhara Tetsuya、Itoh Yoshiaki
- Journal Title
  
  The Open Biomedical Engineering Journal
  
  Volume: 13 Issue: 1 Pages: 55-66
- DOI
  10.2174/1874120701913010055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09806, KAKENHI-PROJECT-18K07507, KAKENHI-PROJECT-16H05324
[Journal Article] First prototyping of a dedicated PET system with the hemisphere detector arrangement2019
- Author(s)
  Tashima Hideaki、Yoshida Eiji、Iwao Yuma、Wakizaka Hidekatsu、Maeda Takamasa、Seki Chie、Kimura Yasuyuki、Takado Yuhei、Higuchi Makoto、Suhara Tetsuya、Yamashita Taichi、Yamaya Taiga
- Journal Title
  
  Physics in Medicine & Biology
  
  Volume: 64 Issue: 6 Pages: 065004-065004
- DOI
  10.1088/1361-6560/ab012c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K21637, KAKENHI-PROJECT-15K21774, KAKENHI-PROJECT-18K06575
[Journal Article] Design, Synthesis, and Evaluation of (4R)-1-{3-[2-(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase2019
- Author(s)
  Hattori Yasushi、Aoyama Kazunobu、Maeda Jun、Arimura Naoto、Takahashi Yasuko、Sasaki Masako、Fujinaga Masayuki、Seki Chie、Nagai Yuji、Kawamura Kazunori、Yamasaki Tomoteru、Zhang Ming-Rong、Higuchi Makoto、Koike Tatsuki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 5 Pages: 2362-2375
- DOI
  10.1021/acs.jmedchem.8b01576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury2019
- Author(s)
  Takahata K、Kimura Yi、Sahara N、Koga S、Shimada H、Ichise M、Saito F、Moriguchi S、Kitamura S、Kubota M、Umeda S、Niwa F、Mizushima J、Morimoto Y、Funayama M、Tabuchi H、Bieniek K. F、Kawamura K、Zhang Ming-Rong、Dickson D. W、Mimura M、Kato M、Suhara T、Higuchi M
- Journal Title
  
  Brain
  
  Volume: 142 Issue: 10 Pages: 3265-3279
- DOI
  10.1093/brain/awz238
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-19H03583
[Journal Article] Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow2018
- Author(s)
  Takahashi Manami、Urushihata Takuya、Takuwa Hiroyuki、Sakata Kazumi、Takado Yuhei、Shimizu Eiji、Suhara Tetsuya、Higuchi Makoto、Ito Hiroshi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 11 Pages: 723-723
- DOI
  10.3389/fnins.2017.00723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06361, KAKENHI-PROJECT-16K19875, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-16K10356
[Journal Article] Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow2018
- Author(s)
  Urushihata Takuya、Takuwa Hiroyuki、 Seki Chie、 Tachibana Yasuhiko、Takahashi Manami、Jeff Kershaw、Takado Yuhei 、Aoki Ichio、Higuchi Makoto、Ito Hiroshi、Obata Takayuki
- Journal Title
  
  MRMS
  
  Volume: 17 Issue: 4 Pages: 318-324
- DOI
  10.2463/mrms.mp.2017-0149
- NAID
  130007496873
- ISSN
  1347-3182, 1880-2206
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17J06361, KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-15H04910, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K10356
[Journal Article] Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans2018
- Author(s)
  Ito Takehito、Kimura Yasuyuki、Seki Chie、Ichise Masanori、Yokokawa Keita、Kawamura Kazunori、Takahashi Hidehiko、Higuchi Makoto、Zhang Ming-Rong、Suhara Tetsuya、Yamada Makiko
- Journal Title
  
  EJNMMI Research
  
  Volume: 8 Issue: 1 Pages: 48-48
- DOI
  10.1186/s13550-018-0406-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17H02173
[Journal Article] In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia2018
- Author(s)
  Colas Lorena、Domercq Maria、Ramos-Cabrer Pedro、Palma Ana、Gomez-Vallejo Vanessa、Padro Daniel、Plaza-Garcia Sandra、Pulagam Krishna R.、Higuchi Makoto、Matute Carlos、Llop Jordi、Martin Abraham
- Journal Title
  
  Glia
  
  Volume: 66 Issue: 8 Pages: 1611-1624
- DOI
  10.1002/glia.23326
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018
- Author(s)
  Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 61 Issue: 3 Pages: 1037-1052
- DOI
  10.3233/jad-170509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
[Journal Article] Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer’s disease2018
- Author(s)
  Kitamura Soichiro、Shimada Hitoshi、Niwa Fumitoshi、Endo Hironobu、Shinotoh Hitoshi、Takahata Keisuke、Kubota Manabu、Takado Yuhei、Hirano Shigeki、Kimura Yasuyuki、Zhang Ming-Rong、Kuwabara Satoshi、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 89 Issue: 11 Pages: 1208-1214
- DOI
  10.1136/jnnp-2018-317970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K19789
[Journal Article] Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula2018
- Author(s)
  Shinotoh Hitoshi、Shimada Hitoshi、Kokubo Yasumasa、Tagai Kenji、Niwa Fumitoshi、Kitamura Soichiro、Endo Hironobu、Ono Maiko、Kimura Yasuyuki、Hirano Shigeki、Mimuro Maya、Ichise Masanori、Sahara Naruhiko、Zhang Ming-Rong、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Neurology
  
  Volume: 92 Issue: 2
- DOI
  10.1212/wnl.0000000000006736
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-16K19872, KAKENHI-PROJECT-18K06575
[Journal Article] Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease2018
- Author(s)
  Soichiro Kitamura, Hitoshi Shimada*, Fumitoshi Niwa, Hironobu Endo, Hitoshi Shinotoh, Keisuke Takahata, Manabu Kubota, Yuhei Takado, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Neurology, Neurosurgery, and Psychiatry
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26713031
[Journal Article] Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia2018
- Author(s)
  Takenoshita Naoto、Fukasawa Raita、Ogawa Yusuke、Shimizu Soichiro、Umahara Takahiko、Ishii Kenji、Shimada Hitoshi、Higuchi Makoto、Suhara Tetsuya、Hanyu Haruo
- Journal Title
  
  Current Alzheimer Research
  
  Volume: 15 Issue: 11 Pages: 1062-1069
- DOI
  10.2174/1567205015666180709113338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09813, KAKENHI-PROJECT-16H05324
[Journal Article] A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors2018
- Author(s)
  Keisuke Takahata et al.,
- Journal Title
  
  EJNMMI research
  
  Volume: 16 Issue: 1 Pages: 63-63
- DOI
  10.1186/s13550-017-0313-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19789, KAKENHI-PROJECT-16K19790, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09977
[Journal Article] Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.2018
- Author(s)
  Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: s1 Pages: S353-S359
- DOI
  10.3233/jad-179933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324
[Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018
- Author(s)
  Matsumoto Gen、Matsumoto Kazuki、Kimura Taeko、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko、Mori Nozomu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 5 Pages: 1497-1497
- DOI
  10.3390/ijms19051497
- NAID
  120006988072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06398
[Journal Article] Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain2018
- Author(s)
  Chiotis Konstantinos、Stenkrona Per、Almkvist Ove、Stepanov Vladimir、Ferreira Daniel、Arakawa Ryosuke、Takano Akihiro、Westman Eric、Varrone Andrea、Okamura Nobuyuki、Shimada Hitoshi、Higuchi Makoto、Halldin Christer、Nordberg Agneta
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 45 Issue: 9 Pages: 1605-1617
- DOI
  10.1007/s00259-018-4012-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-18H02771, KAKENHI-PLANNED-26117003
[Journal Article] Comparative in-vitro quantification of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models2018
- Author(s)
  Ni R, Ji B, Ono M, Sahara N, Zhang M-R, Aoki I, Nordberg A, Suhara T, Higuchi M
- Journal Title
  
  J. Nuclear Medicine
  
  Volume: 117 Issue: 6 Pages: 960-966
- DOI
  10.2967/jnumed.117.201632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K19872
[Journal Article] Tau Filaments and the Development of Positron Emission Tomography Tracers2018
- Author(s)
  Goedert Michel、Yamaguchi Yoshiki、Mishra Sushil K.、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 9 Pages: 70-70
- DOI
  10.3389/fneur.2018.00070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16H04758
[Journal Article] Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to a-synuclein pathology.2017
- Author(s)
  Koga S, Ono M, Sahara N, Higuchi M, Dickson DW.
- Journal Title
  
  Movement Disorder
  
  Volume: - Issue: 6 Pages: 884-892
- DOI
  10.1002/mds.27013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-16H05324
[Journal Article] Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D22017
- Author(s)
  Moriguchi Sho、Takano Harumasa、Kimura Yasuyuki、Nagashima Tomohisa、Takahata Keisuke、Kubota Manabu、Kitamura Soichiro、Ishii Tatsuya、Ichise Masanori、Zhang Ming-Rong、Shimada Hitoshi、Mimura Masaru、Meyer Jeffrey H、Higuchi Makoto、Suhara Tetsuya
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 20 Issue: 12 Pages: 957-962
- DOI
  10.1093/ijnp/pyx069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.2017
- Author(s)
  Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 12 Pages: e0189318-e0189318
- DOI
  10.1371/journal.pone.0189318
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04896, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17H02173
[Journal Article] In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line2017
- Author(s)
  Sahara Naruhiko、Shimojo Masafumi、Ono Maiko、Takuwa Hiroyuki、Febo Marcelo、Higuchi Makoto、Suhara Tetsuya
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 8 Pages: 663-663
- DOI
  10.3389/fneur.2017.00663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K21636
[Journal Article] Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male2017
- Author(s)
  Barron Anna M.、Ji Bin、Kito Seiji、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 1 Pages: 75-85
- DOI
  10.1042/bcj20170645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09979
[Journal Article] Propagation of pathological α-synuclein in marmoset brain2017
- Author(s)
  Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga, Masato Hasegawa
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 5 Issue: 1 Pages: 12-14
- DOI
  10.1186/s40478-017-0413-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Comparison between [ 18 F]fluorination and [ 18 F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [ 18 F]MNI-6592017
- Author(s)
  Mori Wakana、Takei Makoto、Furutsuka Kenji、Fujinaga Masayuki、Kumata Katsushi、Muto Masatoshi、Ohkubo Takayuki、Hashimoto Hiroki、Tamagnan Gilles、Higuchi Makoto、Kawamura Kazunori、Zhang Ming-Rong
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 55 Pages: 12-18
- DOI
  10.1016/j.nucmedbio.2017.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] High-contrast PET imaging of vasopressin V1B receptors with a novel radioligand, 11C-TASP6992017
- Author(s)
  Kazumi Koga, Yugi Nagai, Masayuki Hanyu, Mitsukane Yoshinaga, Shigeyuki Chaki, Norikazu Ohtake, Satoshi Ozaki, Ming-Rong Zhang, Tetsuya Suhara, Makoto HIguchi
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: - Issue: 10 Pages: 1652-1658
- DOI
  10.2967/jnumed.116.188698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861031, KAKENHI-PROJECT-16H05324
[Journal Article] Localized Accumulation of Tau without Amyloid-Beta in Aged Brains Measured with [11C]PBB3 and [11C]Pib Positron Emission Tomography2017
- Author(s)
  Kikukawa Takayuki、Saito Haruna、Hasegawa Itsuki、Takeuchi Jun、Takeda Akitoshi、Kawabe Joji、Wada Yasuhiro、Mawatari Aya、Watanabe Yasuyoshi、Kitamura Soichiro、Shimada Hitoshi、Higuchi Makoto、Suhara Tetsuya、Itoh Yoshiaki
- Journal Title
  
  Journal of Alzheimer’s Disease & Parkinsonism
  
  Volume: 07 Issue: 06 Pages: 401-401
- DOI
  10.4172/2161-0460.1000401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09806, KAKENHI-PROJECT-26713031, KAKENHI-PROJECT-26461316
[Journal Article] Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia2017
- Author(s)
  Kubota Manabu、Nagashima Tomohisa、Takano Harumasa、Kodaka Fumitoshi、Fujiwara Hironobu、Takahata Keisuke、Moriguchi Sho、Kimura Yasuyuki、Higuchi Makoto、Okubo Yoshiro、Takahashi Hidehiko、Ito Hiroshi、Suhara Tetsuya
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 20 Issue: 11 Pages: 928-935
- DOI
  10.1093/ijnp/pyx063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease2017
- Author(s)
  Tsunoda Keiichiro、Yamashita Toru、Shimada Hitoshi、Nomura Emi、Takahashi Yoshiaki、Shang Jingwei、Sato Kota、Takemoto Mami、Hishikawa Nozomi、Ohta Yasuyuki、Higuchi Makoto、Suhara Tetsuya、Kokubo Yasumasa、Kuzuhara Shigeki、Abe Koji
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 46 Pages: 64-67
- DOI
  10.1016/j.jocn.2017.08.057
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09364, KAKENHI-PROJECT-25305030, KAKENHI-PROJECT-26713031, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-16H05324
[Journal Article] PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins2017
- Author(s)
  Perez-Soriano Alexandra、Arena Julieta E.、Dinelle Katie、Miao Qing、McKenzie Jessamyn、Neilson Nicole、Puschmann Andreas、Schaffer Paul、Shinotoh Hitoshi、Smith-Forrester Jenna、Shahinfard Elham、Vafai Nasim、Wile Daryl、Wszolek Zbigniew、Higuchi Makoto、Sossi Vesna、Stoessl A. Jon
- Journal Title
  
  Movement Disorders
  
  Volume: 32 Issue: 7 Pages: 1016-1024
- DOI
  10.1002/mds.27029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Journal Article] Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol2017
- Author(s)
  Yasuyuki Kimura, Jun Maeda, Makiko Yamada, Keisuke Takahata, Keita Yokokawa, Yoko Ikoma, Chie Seki, Hiroshi Ito, Makoto Higuchi, Tetsuya Suhara
- Journal Title
  
  Psychopharmacology
  
  Volume: 234 Issue: 3 Pages: 323-328
- DOI
  10.1007/s00213-016-4464-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-16K10356
[Journal Article] Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study2017
- Author(s)
  Shimada H, Kitamura S, Shinoto H, Endo H, Niwa F, Hirano, S Zhang M-R, Suhara T, Higuchi M
- Journal Title
  
  Alzheimer’s & Dementia (Amst)
  
  Volume: 6 Issue: 1 Pages: 11-20
- DOI
  10.1016/j.dadm.2016.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-26713031
[Journal Article] Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders.2017
- Author(s)
  71.Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M.
- Journal Title
  
  Brain
  
  Volume: 140 Pages: 764-780
- DOI
  10.1093/brain/aww339
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979
[Journal Article] Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography.2016
- Author(s)
  Moraga A, Gomez-Vallejo V, Cuartero MI, Szczupak B, San Sebastian E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MA, Martin A, Lizasoain I
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 36 Issue: 4 Pages: 702-708
- DOI
  10.1177/0271678x15627657
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] DREADD-expressing neurons in living brain and their application to implantation of iPSC-derived neuroprogenitors.2016
- Author(s)
  Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M.
- Journal Title
  
  J. Neuroscience
  
  Volume: 36 Issue: 45 Pages: 11544-11558
- DOI
  10.1523/jneurosci.1279-16.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05917, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-26282221, KAKENHI-PROJECT-15K12772, KAKENHI-PLANNED-25111005
[Journal Article] [11C]TASP457, a novel PET ligand for histamine H3 receptors in human brain. Eur J Nucl Med Mol Imaging.2016
- Author(s)
  Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang MR, Suhara T
- Journal Title
  
  Eur J Nucl Med Mol Imaging
  
  Volume: 1 Issue: 9 Pages: 1-11
- DOI
  10.1007/s00259-016-3332-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25861039
[Journal Article] Synthesis and preclinical evaluation of sulfonamido-based [11C-Carbonyl]-carbamates and ureas for imaging monoacylglycerol lipase.2016
- Author(s)
  Wang L, Mori W, Cheng R, Yui J, Hatori A, Ma L, Zhang Y, Rotstein BH, Fujinaga M, Shimoda Y, Yamasaki T, Xie L, Nagai Y, Minamimoto T, Higuchi M, Vasdev N, Zhang MR, Liang SH.
- Journal Title
  
  Theranostics
  
  Volume: 6(8) Issue: 8 Pages: 1145-1159
- DOI
  10.7150/thno.15257
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05917, KAKENHI-PROJECT-16H05324
[Journal Article] PET Quantification in Molecular Brain Imaging Taking into Account the Contribution of the Radiometabolite Entering the Brain2016
- Author(s)
  Ichise M., Kimura Y., Shimada H., Higuchi M., Suhara T.
- Journal Title
  
  Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
  
  Volume: １ Pages: 219-228
- Open Access
- Data Source
  KAKENHI-PROJECT-26713031
[Journal Article] Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons2016
- Author(s)
  Imamura, K., Sahara, N., Kanaan, N. M., Tsukita, K., Kondo, T., Kutoku, Y., Ohsawa, Y., Sunada, Y., Kawakami, K., Hotta, A., Yawata, S., Watanabe, D., Hasegawa, M., Trojanowski, J. Q., Lee, V. M.-Y., Suhara, T., Higuchi, M., and Inoue, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 34904-34904
- DOI
  10.1038/srep34904
- NAID
  120005850272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26112007, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-24220009, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K14315, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-16K06993, KAKENHI-PROJECT-15H02370
[Journal Article] A new method to quantify tau pathologies with 11C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.2016
- Author(s)
  Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang MR, Suhara T
- Journal Title
  
  EJNMMI Res
  
  Volume: 6 Issue: 1 Pages: 24-24
- DOI
  10.1186/s13550-016-0182-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-26713031
[Journal Article] TASP0434299: A novel pyridopyrimidin-4-one derivative as a radioligand for vasopressin V1B receptor.2016
- Author(s)
  Koga K, Yoshinaga M, Uematsu Y, Nagai Y, Miyakoshi N, Shimoda Y, Fujinaga M, Minamimoto T, Zhang MR, Higuchi M, Ohtake N, Suhara T, Chaki S
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 357 Issue: 3 Pages: 495-508
- DOI
  10.1124/jpet.116.232942
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors2016
- Author(s)
  Kazumi Koga, Jun Maeda, Masaki Tokunaga, Masayuki Hanyu, Kazunori Kawamura, Mari Ohmichi, Toshio Nakamura, Yuji Nagai, Chie Seki, Yasuyuki Kimura, Takafumi Minamimoto, Ming-Rong Zhang, Toshimitsu Fukumura, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  EJNMMI Research
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1186/s13550-016-0170-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861031, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25460114, KAKENHI-PLANNED-15H05917
[Journal Article] Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET2016
- Author(s)
  Barron A, Tokunaga M, Zhang M-R, Bin Ji, Suhara T, Higuchi M
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 13 Issue: 1 Pages: 221-221
- DOI
  10.1186/s12974-016-0700-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324
[Journal Article] Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging.2015
- Author(s)
  Masafumi Shimojo, Makoto Higuchi, Tetsuya Suhara, Naruhiko Sahara
- Journal Title
  
  Frontiers in neuroscience
  
  Volume: 9 Pages: 482-482
- DOI
  10.3389/fnins.2015.00482
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06793, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-26117008
[Journal Article] PET Quantification of Tau Pathology in Human Brain with 11C-PBB32015
- Author(s)
  Yasuyuki Kimura, Masanori Ichise, Hiroshi Ito, Hitoshi Shimada, Yoko Ikoma, Chie Seki, Harumasa Takano, Soichiro Kitamura, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of nuclear medicine
  
  Volume: 56 Issue: 9 Pages: 1359-1365
- DOI
  10.2967/jnumed.115.160127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06793, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25461862, KAKENHI-PROJECT-26713031, KAKENHI-PLANNED-26117008
[Journal Article] Development of 1-N-(11)C-Methyl-L- and -D-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.2015
- Author(s)
  Xie L, Maeda J, Kumata K, Yui J, Zhang Y, Hatori A, Nengaki N, Wakizaka H, Fujinaga M, Yamasaki T, Shimoda Y, Higuchi M, Suhara T, Wang F, Zhang MR
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 16417-16417
- DOI
  10.1038/srep16417
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease2015
- Author(s)
  Ji B, Chen CJ, Bando K, Ashino H, Shiraishi H, Sano H, Kasahara H, Minamizawa T, Yamada K, Ono M, Zhang MR, Seki C, Farde L, Suhara T, Higuchi M
- Journal Title
  
  J Neurochem
  
  Volume: 135 Issue: 5 Pages: 859-66
- DOI
  10.1111/jnc.13293
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Identification of a major radiometabolite of [11C]PBB3.2015
- Author(s)
  Hashimoto H, Kawamura K, Takei M, Igarashi N, Fujishiro T, Shiomi S, Watanabe R, Muto M, Furutsuka K, Ito T, Yamasaki T, Yui J, Nemoto K, Kimura Y, Higuchi M, Zhang MR
- Journal Title
  
  Nucl Med Biol
  
  Volume: 42 Issue: 12 Pages: 905-910
- DOI
  10.1016/j.nucmedbio.2015.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors.2015
- Author(s)
  Oi N, Tokunaga M, Suzuki M, Nagai Y, Nakatani Y, Yamamoto N, Maeda J, Minamimoto T, Zhang MR, Suhara T, Higuchi M
- Journal Title
  
  J Med Chem
  
  Volume: 58 Issue: 21 Pages: 8444-8462
- DOI
  10.1021/acs.jmedchem.5b00712
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] [18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain2015
- Author(s)
  Tiwari AK, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang MR.
- Journal Title
  
  Theranostics
  
  Volume: 26 Issue: 9 Pages: 961-9
- DOI
  10.7150/thno.12027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] In vivo PET imaging of the α4β2 nicotinic acetylcholine receptor as a marker for brain inflammation after cerebral ischemia.2015
- Author(s)
  Martin A, Szczupak B, Gomez-Vallejo V, Domercq M, Cano A, Padro D, Munoz C, Higuchi M, Matute C, Llop J
- Journal Title
  
  J Neurosci
  
  Volume: 36 Issue: 15 Pages: 5998-6009
- DOI
  10.1523/jneurosci.3670-14.2015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] In vivo SPECT imaging of amyloid-β deposition with radioiodinated imidazo[1,2-a]pyridine derivative DRM106 in a mouse model of Alzheimer's disease2015
- Author(s)
  Chen CJ, Bando K, Ashino H, Taguchi K, Shiraishi H, Shima K, Fujimoto O, Kitamura C, Matsushima S, Uchida K, Nakahara Y, Kasahara H, Minamizawa T, Jiang C, Zhang MR, Ono M, Tokunaga M, Suhara T, Higuchi M, Yamada K, Ji B.
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 56 Issue: 1 Pages: 120-126
- DOI
  10.2967/jnumed.114.146944
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] 認知症診断におけるtau,amyloid imagingの役割2015
- Author(s)
  島田　斉 , 丸山　将浩 , 樋口　真人 , 須原　哲也
- Journal Title
  
  臨床画像
  
  Volume: 30 Pages: 177-186
- Data Source
  KAKENHI-PROJECT-26713031
[Journal Article] Quantification of central substance p receptor occupancy by aprepitant using small animal positron emission tomography2014
- Author(s)
  Endo T, Saijo T, Haneda E, Maeda J, Tokunaga M, Zhang MR, Kannami A, Asai H, Suzuki M, Suhara T, Higuchi M.
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 18 Issue: 2 Pages: pyu030-pyu030
- DOI
  10.1093/ijnp/pyu030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB2014
- Author(s)
  Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 41 Issue: 4 Pages: 745-754
- DOI
  10.1007/s00259-013-2620-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-24243061
[Journal Article] Comparison of imaging biomarkers for Alzheimer's disease: amyloid imaging with [18F]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy2014
- Author(s)
  Tateno A, Sakayori T, Kawashima Y, Higuchi M, Suhara T, Mizumura S, Mintun MA, Skovronsky DM, Honjo K, Ishihara K, Kumita S, Suzuki H, Okubo Y.
- Journal Title
  
  International Journal of Geriatric Psychiatry
  
  Volume: 30 Issue: 5 Pages: 505-513
- DOI
  10.1002/gps.4173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390292, KAKENHI-PROJECT-15H04896
[Journal Article] Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer's disease2014
- Author(s)
  Chen CJ, Bando K, Ashino H, Taguchi K, Shiraishi H, Fujimoto O, Kitamura C, Matsushima S, Fujinaga M, Zhang MR, Kasahara H, Minamizawa T, Jiang C, Ono M, Higuchi M, Suhara T, Yamada K, Ji B.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 15 Pages: 4189-4197
- DOI
  10.1016/j.bmc.2014.05.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Amyloid imaging with [18 F]florbetapir in geriatric depression: early-onset versus late-onset2014
- Author(s)
  Tateno A, Sakayori T, Higuchi M, Suhara T, Ishihara K, Kumita S, Suzuki H, Okubo Y.
- Journal Title
  
  International Journal of Geriatric Psychiatry
  
  Volume: in press Issue: 7 Pages: 720-728
- DOI
  10.1002/gps.4215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390292, KAKENHI-PROJECT-15H04896
[Journal Article] Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice2014
- Author(s)
  Wang B, Tanaka K, Ji B, Ono M, Fang Y, Ninomiya Y, Maruyama K, Izumi-Nakajima N, Begum N, Higuchi M, Fujimori A, Uehara Y, Nakajima T, Suhara T, Ono T, Nenoi M
- Journal Title
  
  J Radiat Res
  
  Volume: 55 Issue: 1 Pages: 84-96
- DOI
  10.1093/jrr/rrt096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25340041
[Journal Article] Biochemical Distribution of Tau Protein in Synaptosomal Fraction of Transgenic Mice Expressing Human P301L Tau2014
- Author(s)
  Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A.
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 5 Pages: 26-26
- DOI
  10.3389/fneur.2014.00026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PUBLICLY-24111562, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117008
[Journal Article] Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology2014
- Author(s)
  Hashimoto H, Kawamura K, Igarashi N, Takei M, Fujishiro T, Aihara Y, Shiomi S, Muto M, Ito T, Furutsuka K, Yamasaki T, Yui J, Xie L, Ono M, Hatori A, Nemoto K, Suhara T, Higuchi M, Zhang MR.
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 55 Issue: 9 Pages: 932-938
- DOI
  10.2967/jnumed.114.139550
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor2013
- Author(s)
  Oi N, Suzuki M, Terauchi T, Tokunaga M, Nakatani Y, Yamamoto N, Fukumura T, Zhang MR, Suhara T, Higuchi M.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 56 Issue: 16 Pages: 6371-6385
- DOI
  10.1021/jm400772t
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model2013
- Author(s)
  Ji B, Kumata K, Onoe H, Kaneko H, Zhang MR, Seki C, Ono M, Shukuri M, Tokunaga M, Minamihisamatsu T, Suhara T, Higuchi M
- Journal Title
  
  Brain Research
  
  Volume: 1533 Pages: 152-162
- DOI
  10.1016/j.brainres.2013.08.026
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-24790269
[Journal Article] In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI)2013
- Author(s)
  Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T.
- Journal Title
  
  Frontiers in Integrative Neuroscience
  
  Volume: 40 Pages: 125-132
- DOI
  10.3389/fnint.2013.00076
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24300167, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25242078
[Journal Article] Comparison of the binding characteristics of [^<18>F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology2013
- Author(s)
  Ryuichi Harada
- Journal Title
  
  European Journal of Nuclear Medicine and Molecular Imaging
  
  Volume: 40 Issue: 1 Pages: 125-132
- DOI
  10.1007/s00259-012-2261-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07785, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PROJECT-24659255, KAKENHI-PLANNED-23111009
[Journal Article] Nitric oxide signaling exerts bidirectional effects on plasticity inductions in amygdala2013
- Author(s)
  Shin RM, Higuchi M, Suhara T.
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 9 Pages: e74668-e74668
- DOI
  10.1371/journal.pone.0074668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder2013
- Author(s)
  Nakatani Y, Suzuki M, Tokunaga M, Maeda J, Sakai M, Ishihara H, Yoshinaga T, Takenaka O, Zhang MR, Suhara T, Higuchi M.
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 9 Pages: e75040-e75040
- DOI
  10.1371/journal.pone.0075040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013
- Author(s)
  Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 38(8) Issue: 8 Pages: 1409-25
- DOI
  10.1038/npp.2013.38
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-22380078, KAKENHI-PROJECT-22500342, KAKENHI-PROJECT-22651075, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23370079, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23792018, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24657008, KAKENHI-PROJECT-24791244, KAKENHI-PROJECT-25460114, KAKENHI-PLANNED-22125005
[Journal Article] Superiority illusion arises from resting-state brain network modulated by dopamine.2013
- Author(s)
  Yamada, M., Uddin, L. Q., Takahashi, H., Kimura, Y., Takahata, K., Kousa, R., Ikoma, Y., Eguchi, Y., Takano, H., Ito, H., Higuchi, M., & Suhara, T.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 110 Issue: 11 Pages: 4363-4367
- DOI
  10.1073/pnas.1221681110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220003, KAKENHI-PLANNED-23120009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23680045, KAKENHI-PROJECT-24243061, KAKENHI-PROJECT-24791251, KAKENHI-PROJECT-25861039, KAKENHI-PLANNED-23111009
[Journal Article] Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice2013
- Author(s)
  Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 1472-1472
- DOI
  10.1038/srep01472
- NAID
  120006985953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23590473, KAKENHI-PROJECT-24790260, KAKENHI-PUBLICLY-25110729, KAKENHI-PUBLICLY-23110515, KAKENHI-PUBLICLY-23110535
[Journal Article] Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination2013
- Author(s)
  Kanekiyo K, Inamori K, Kitazume S, Sato K, Maeda J, Higuchi M, Kizuka Y, Korekane H, Matsuo I, Honke K, Taniguchi N
- Journal Title
  
  J. Neurosci.
  
  Volume: 33(24) Issue: 24 Pages: 10037-10047
- DOI
  10.1523/jneurosci.3137-12.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25430122, KAKENHI-PROJECT-25670166
[Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013
- Author(s)
  Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
- Journal Title
  
  Neuron
  
  Volume: 79 Issue: 6 Pages: 1094-1108
- DOI
  10.1016/j.neuron.2013.07.037
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25670524
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012
- Author(s)
  Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC
- Journal Title
  
  FASEB J
  
  Volume: 26(3) Issue: 3 Pages: 1204-1217
- DOI
  10.1096/fj.11-187740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] 画像・バイオマーカーによるアルツハイマー病の早期診断2012
- Author(s)
  樋口真人
- Journal Title
  
  カレントテラピー[別冊]
  
  Volume: 30(4) Pages: 22-29
- Data Source
  KAKENHI-PROJECT-22790836
[Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders2012
- Author(s)
  Higuchi M, Maeda J, Ji B, Tokunaga M, Zhang MR, Maruyama M, Ono M, Fukumura T, Suhara T
- Journal Title
  
  Curr Top Behav Neurosci
  
  Volume: 11 Pages: 45-64
- DOI
  10.1007/7854_2011_167
- ISBN
  9783642287107, 9783642287114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-23111009
[Journal Article] 認知症のバイオマーカーイメージング2012
- Author(s)
  樋口真人
- Journal Title
  
  Cognition and Dementia
  
  Volume: 12(1) Pages: 34-40
- Data Source
  KAKENHI-PROJECT-22790836
[Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models2010
- Author(s)
  Higuchi M, et al.
- Journal Title
  
  Biochimica et Biophysica Acta 1802
  
  Pages: 373-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023036
[Journal Article] Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease2009
- Author(s)
  Higuchi M
- Journal Title
  
  Current Alzheimer Research 6
  
  Pages: 137-143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023036
[Journal Article] Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System2009
- Author(s)
  M Tokunaga, N Seneca, RM Shin, J Maeda, S Obayashi, T Okauchi, Y Nagai, MR Zhang, R Nakano, H Ito, RB. Innis, C Halldin, K Suzuki, M Higuchi, T Suhara
- Journal Title
  
  The Journal of Neuroscience 26
  
  Pages: 1887-1896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390309
[Journal Article] Animal models of tauopathies2006
- Author(s)
  Higuchi M et al.
- Journal Title
  
  Neuropathology 26
  
  Pages: 1309-1310
- NAID
  10020347570
- Data Source
  KAKENHI-PROJECT-17790595
[Journal Article] Animal models of tauopathies2006
- Author(s)
  Higuchi M et al.
- Journal Title
  
  Neuropathology 26
  
  Pages: 1309-1310
- NAID
  10020347570
- Data Source
  KAKENHI-PROJECT-18023040
[Journal Article] Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.2005
- Author(s)
  Higuchi M et al.
- Journal Title
  
  Journal of Biological Chemistry 280
  
  Pages: 15229-15237
- Data Source
  KAKENHI-PROJECT-17790595
[Journal Article] Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies.2005
- Author(s)
  Higuchi M et al.
- Journal Title
  
  Journal of Neuroscience 25
  
  Pages: 9434-9443
- Data Source
  KAKENHI-PROJECT-17790595
[Journal Article] ^<19>F- and ^1H-MRI detection of amyloid-β plaques in vivo.2005
- Author(s)
  Higuchi M et al.
- Journal Title
  
  Nature Neuroscience 8
  
  Pages: 527-533
- Data Source
  KAKENHI-PROJECT-17790595
[Patent] αシヌクレイン凝集体結合剤及びイメージング方法2020
- Inventor(s)
  樋口真人, 小野麻衣子, 須原哲也, 張明栄
- Industrial Property Rights Holder
  樋口真人, 小野麻衣子, 須原哲也, 張明栄
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-16H05324
[Patent] αシヌクレイン凝集体結合剤及びイメージング方法2019
- Inventor(s)
  樋口真人、小野麻衣子、須原哲也、張明栄
- Industrial Property Rights Holder
  量子科学技術研究開発機構
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05324
[Patent] 四足動物保定装置2017
- Inventor(s)
  樋口真人、田桑弘之、高堂裕平、漆畑拓弥
- Industrial Property Rights Holder
  量子科学技術研究開発機構
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-164080
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05324
[Patent] NOVEL COMPOUNDS FOR IMAGING TAU PROTEINS THAT　ACCUMULATE IN BRAIN2014
- Inventor(s)
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Holder
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23390235
[Patent] NOVEL COMPOUNDS FOR IMAGING TAU PROTEINS THAT　ACCUMULATE IN BRAIN2014
- Inventor(s)
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Holder
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23390235
[Patent] 脳内に蓄積したタンパク質をイメージングするための新規化合物2013
- Inventor(s)
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Holder
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2013-07-05
- Acquisition Date
  2013-11-29
- Data Source
  KAKENHI-PROJECT-23390235
[Patent] 脳内に蓄積したタンパク質をイメージングするための新規化合物2013
- Inventor(s)
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Holder
  樋口真人, 須原哲也, 丸山将浩, 張明栄, 島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2013-12-20
- Overseas
- Data Source
  KAKENHI-PROJECT-23390235
[Patent] 脳内に蓄積したタウタンパク質をイメージングするための新規化合物2012
- Inventor(s)
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Holder
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-21
- Overseas
- Data Source
  KAKENHI-PROJECT-23390235
[Patent] 脳内に蓄積したタウタンパク質をイメージングするための新規化合物2012
- Inventor(s)
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Holder
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-21
- Overseas
- Data Source
  KAKENHI-PLANNED-23111009
[Patent] 脳内に蓄積したタウタンパク質をイメージングするための新規化合物2012
- Inventor(s)
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Holder
  樋口真人、須原哲也、丸山将浩、張明栄、島田斉
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-21
- Acquisition Date
  2013-11-29
- Data Source
  KAKENHI-PLANNED-23111009
[Patent] PET visualization of amyloid-associated neuroinflammation in the brain2008
- Inventor(s)
  須原哲也・鈴木和年・樋口真人・張明栄・前田純・季斌
- Industrial Property Rights Holder
  須原哲也・鈴木和年・樋口真人・張明栄・前田純・季斌
- Filing Date
  2008-03-12
- Overseas
- Data Source
  KAKENHI-PROJECT-18023040
[Presentation] アルツハイマー病の脳内異常タンパク質と歯数の関連 - PET研究-2024
- Author(s)
  松元秀樹、互健二、遠藤浩信、松岡究、高堂裕平、小久保奈緒美、島田斉、後藤哲哉、後藤多津子、樋口真人
- Organizer
  NPO法人日本歯科放射線学会第237回関東地方会
- Data Source
  KAKENHI-PROJECT-22K19636
[Presentation] 進行性核上性麻痺におけるタウタンパク集積や酸化ストレスとアパシーの関連2022
- Author(s)
  松岡究、高堂裕平、互健二、久保田学、佐野康徳、高畑圭輔、小野麻衣子、関千江、松元秀樹、遠藤浩信、篠遠仁、佐原慈佳、小畠隆行、Jamie Near、河村和紀、張明栄、須原哲也、島田斉、樋口真人
- Organizer
  第44回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-22K19636
[Presentation] Rightward lateralization of frontal cortex tau pathologies is associated with late-onset psychosis: A PET study with 18F-Flozolotau (18F-PM-PBB3)2022
- Author(s)
  Kurose S, Takahata K, Moriguchi S, Tagai K, Kubota M, Sano Y, Yamamoto Y, Endo H, Hirata K, Matsuoka K, Oya M, Matsumoto H, Kokubo N, Koreki A, Suzuki H, Ogyu K, Mashima Y., Mimura Y, Nakajima S, Bun S, Seki C, Takado Y, Sahara N, Onaya M, Mimura M, Higuchi M
- Organizer
  The Alzheimer's Association International Conference, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19636
[Presentation] Molecular imaging in neurodegeneration: look to the future and implement in the reality2021
- Author(s)
  Makoto Higuchi
- Organizer
  2021 Asian and Oceanian Congress of Neurology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] Multimodal Imaging of Tau and α-Synuclein Pathologies2021
- Author(s)
  Makoto Higuchi
- Organizer
  The 15th International Conference on Alzheimer’s and Parkinson’s Diseases (ADPD 2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] 精神・神経疾患のイメージングバイオマーカー2021
- Author(s)
  樋口　真人
- Organizer
  第121回日本医学物理学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] : MRI and PET imaging features of retired athletes with repetitive mild traumatic brain injury2021
- Author(s)
  Miyata M, Takahata K, Mimura M, Higuchi M
- Organizer
  RSNA2021, 2021.11.28-12.2, Chicago, USA (WEB開催)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] Multimodal PET2021
- Author(s)
  Makoto Higuchi
- Organizer
  International Conference of Korean Movement Disorder Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] : 高齢発症の双極性障害患者における脳内アミロイド・タウ蓄積、神経心理症状の評価: 11C-PiB, 18F-PM-PBB3を用いた縦断PET研究2021
- Author(s)
  佐野康徳, 高畑圭輔, 森口翔, 山本保天, 黒瀬心, 小久保奈緒美, 小西海香, 瓦健二, 平田浩聖, 松岡究, 遠藤浩信, 高堂祐平, 斎藤文恵, 樋口真人, 三村將
- Organizer
  第45回日本神経心理学会学術集会, 日本教育会館＋WEB開催, 2021.9.30
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] 認知症イメージングの国際展開2021
- Author(s)
  樋口　真人
- Organizer
  第42回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] 精神疾患と神経疾患をつなぐ生体イメージング研究開発2021
- Author(s)
  樋口　真人
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] 画像バイオマーカーを駆使した次世代認知症診療システムの構築2021
- Author(s)
  樋口　真人
- Organizer
  日本脳神経外科学会第80回学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03583
[Presentation] Tau imaging2020
- Author(s)
  Higuchi Makoto
- Organizer
  The 18th Conference of Peace through Mind/Brain Science
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] In-vivo assessments of protein fibrillogenesis, oxidative stress, and reactive gliosis2020
- Author(s)
  Higuchi Makoto
- Organizer
  The 8th International Symposium of Gunma University Initiative for Advanced Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Imaging neural and glial pathways and their functions in homeostasis and pathogenesis2020
- Author(s)
  Higuchi Makoto
- Organizer
  The 10th Niigata University Brain Research Institute International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Future Molecular Imaging Techniques in Neurodegenerative Diseases2019
- Author(s)
  Higuchi Makoto
- Organizer
  2019 International Conference of Korean Movement Disorder Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] In Vivo Optical and PET Imaging of Disseminating Alpha-synuclein Pathologies in Animal Models2019
- Author(s)
  Higuchi Makoto
- Organizer
  Michael J. Fox Foundation alpha-Synuclein Imaging Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 認知症の診断・治療へ貢献する核医学イメージングの新展開2019
- Author(s)
  樋口真人
- Organizer
  日本核医学会近畿地方会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] グリアリンパ系と脳内ミエロイドリレー：新たに発見された脳内インフラの役割2019
- Author(s)
  樋口真人
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Updates on PET imaging of tau pathologies2019
- Author(s)
  Higuchi Makoto
- Organizer
  第60回日本神経学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Roles of astrocytes in Alzheimer's disease revealed by multiscale in vivo imaging2019
- Author(s)
  Higuchi Makoto
- Organizer
  International Symposium on Reactive Astrocytes and Alzheimer's Disease of The Brain Research Program
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Novel homeostatic function of glial cells in health and disease2019
- Author(s)
  Higuchi Makoto
- Organizer
  第60回日本神経学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] アルツハイマー病における神経病理イメージングの特徴と神経障害の関連.2019
- Author(s)
  青原健太, 武田景敏, 竹内潤，和田康弘，渡辺恭良，島田斉，樋口真人，伊藤義彰.
- Organizer
  第116回日本内科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09806
[Presentation] Imaging of tau pathologies with PBB3 and its fluorinated derivatives2019
- Author(s)
  Higuchi Makoto
- Organizer
  Molecular Imaging Analysis on Brain Disorders - Fukui 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Tau PET Ligands2018
- Author(s)
  樋口真人
- Organizer
  MDS-AOS Neuroimaging Course
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Molecular imaging of Alzheimer's disease and related disorders2018
- Author(s)
  樋口真人
- Organizer
  The 32nd Korean Academy of Science and Technology International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Imaging of neuropathology and functional disruptions in neurodegenerative dementias2018
- Author(s)
  樋口真人
- Organizer
  UK-Japan Neuroscience Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] New Frontiers in Molecular Imaging2018
- Author(s)
  樋口真人
- Organizer
  The 22nd International Congress of Parkinson's Disease and Movement Disorders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Molecular imaging for diagnosis and treatment of neurodegenerative disorders at a prodromal stage2018
- Author(s)
  樋口真人
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Amyloid and Tau imaging in patients with Posterior Cortical Atrophy2018
- Author(s)
  Akitoshi Takeda, Jun Takeuchi, Haruna Saito, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Hisashi Doi, Yasuyoshi Watanabe, Soichiro Kitamura, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh.
- Organizer
  AAIC2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09806
[Presentation] Visualization of proteinopathies in Alzheimer's disease and allied neurodegenerative disorders2018
- Author(s)
  樋口真人
- Organizer
  KSCPT-JSCPT Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 精神神経疾患の分子病態イメージング2018
- Author(s)
  樋口真人
- Organizer
  第28回東京臨床脳画像解析研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] [11C]PBB3-PETを用いた神経原線維変化優位型認知症の脳内タウ蓄積分布に関する検討.2018
- Author(s)
  竹内潤, 齊藤明奈, 武田景敏, 河邉譲治, 和田康弘, 馬渡彩, 土居久志, 渡辺恭良, 北村聡一郎, 島田斉, 樋口真人, 須原哲也, 伊藤義彰.
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09806
[Presentation] 11C-PBB3 Tau Imaging in Logopenic Variant Primary Progressive Aphasia2018
- Author(s)
  Akitoshi Takeda, Jun Takeuchi, Haruna Saito, Joji Kawabe, Hideko Mizuta, Yasuhiro Wada, Aya Mawatari, Ami Igesaka, Hisashi Doi, Yasuyoshi Watanabe, Soichiro Kitamura, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh.
- Organizer
  ICFD2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09806
[Presentation] Imaging of tau pathologies and tau-induced neurodegeneration2018
- Author(s)
  樋口真人，島田斉，須原哲也
- Organizer
  2018 International Conference on Neurodegenerative Disorders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Imaging Molecular Pathologies of Alzheimer's Disease and Related Neurodegenerative Disorders2018
- Author(s)
  樋口真人
- Organizer
  International Alzheimer's Disease Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Logopenic型進行性失語症患者における臨床症状とアミロイド・タウPETとの関連.2018
- Author(s)
  武田景敏, 竹内潤, 齊藤明奈, 河邉譲治, 和田康宏, 馬渡彩, 神母坂あみ, 土居久志, 渡邊恭良, 北村聡一郎, 島田斉, 樋口真人, 須原哲也, 伊藤義彰.
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09806
[Presentation] Imaging tau with 11C-PBB3 and its 18F derivatives2017
- Author(s)
  樋口真人
- Organizer
  The 30th Annual Congress of the European Association of Nuclear Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Current status in development of next generation tau ligands2017
- Author(s)
  島田斉、樋口真人
- Organizer
  International Tau Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 小動物専用マルチピンホールSPECTを用いた[99mTc]HMPAOによるラット脳血流画像撮像の基礎的検討2017
- Author(s)
  関千江、杉田卓、近藤祐介、山下佳輝、脇坂秀克、堀口隆司、須原哲也、樋口真人
- Organizer
  第５６回日本核医学会学術総会
- Place of Presentation
  名古屋国際会議場、愛知県名古屋市
- Year and Date
  2017-11-03
- Data Source
  KAKENHI-PROJECT-15K09978
[Presentation] Imaging-Pathological Correlations of Parkinson’s Disease2017
- Author(s)
  樋口真人
- Organizer
  The 21th International Congress of Parkinson's Disease and Movement Disorders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] In vitro and in vivo evaluation of inhibitory effect of dopamine on [18F]FE-PE2I binding to dopamine transporter in rat brains2017
- Author(s)
  Chie Seki, Masaki Tokunaga, Fumihiko Kodaka, Jun Maeda, Yasuyuki Kimura, Hiroyuki Takuwa, Yoko Ikoma, Hiroshi Ito, Tetsuya Suhara, and Makoto Higuchi
- Organizer
  BRAIN & BRAIN PET 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09978
[Presentation] Neurodegenerative dementias as proteinopathies2017
- Author(s)
  樋口真人
- Organizer
  Brain Networks: From Molecules To Diseases, Neuroscience and Mental Health
- Place of Presentation
  Singapore
- Year and Date
  2017-03-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 腹腔内FDG投与後のPETによる人工受容体DREADDの神経活動制御作用の画像化2017
- Author(s)
  関　千江 , 季　斌 , 内田　翔子 , 南久松　丈晴 , 徳永　正希 , 前田　純 , 脇坂　秀克 , 永井　裕司 , 南本　敬史 , 須原　哲也 , 樋口　真人
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09978
[Presentation] Alzheimer病におけるアパシー症状とタウ病変の関係性2017
- Author(s)
  北村　聡一郎, 島田　斉, 篠遠　仁, 丹羽文俊, 遠藤浩信, 高畑　圭輔, 久保田　学, 高堂　裕平, 平野　成樹, 木村　泰之, 張　明栄, 桑原聡, 須原　哲也, 樋口　真人
- Organizer
  第56回千葉核医学研究会
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Localized tau accumulation in aging without obvious Aβ burden2017
- Author(s)
  Jun Takeuchi, Saito Haruna, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Hisashi Doi, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh
- Organizer
  WCN2017, 2017/9/20
- Data Source
  KAKENHI-PROJECT-26461316
[Presentation] 原発性進行性失語症における[11C]PBB3-PETの検討2017
- Author(s)
  武田景敏、竹内　潤、齊藤明奈、河邉譲治、水田秀子、和田康弘、馬渡彩、土居久志、渡邊恭良、北村聡一郎、島田斉、樋口真人、須原哲也、伊藤義彰,
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-26461316
[Presentation] Current status in development of next generation tau ligands2017
- Author(s)
  島田　斉, 樋口　真人
- Organizer
  International Tau Symposium 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Posterior cortical atrophy患者におけるアミロイド・タウPETと臨床症状との関連2017
- Author(s)
  武田景敏、竹内潤、齊藤明奈、河邉譲治、和田康弘、馬渡彩、土居久志、渡邊恭良、北村聡一郎、島田斉、樋口真人、須原哲也、伊藤義彰
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-26461316
[Presentation] 神経変性疾患病理の生体イメージング2017
- Author(s)
  樋口真人
- Organizer
  第13回パーキンソン病臨床懇話会
- Place of Presentation
  埼玉県さいたま市
- Year and Date
  2017-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] タウ病変の生体イメージング2016
- Author(s)
  樋口真人
- Organizer
  Stroke 2016
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-04-15
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 放射線応答と認知障害をつなぐ神経免疫細胞のイメージング2016
- Author(s)
  樋口真人
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  広島県広島市
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Quantification and reference optimization of tau PET imaging with [11C] PBB3 in PSP patients2016
- Author(s)
  Hitoshi Shimada , Yasuyuki Kimura , Masanori Ichise , Hiroshi Ito , Hironobu Endo , Keisuke Takahata , Fumitoshi Niwa , Soichiro Kitamura , Shigeki Hirano , Hitoshi Shinotoh , Naruhiko Sahara , Makiko Yamada , Ming-Rong Zhang , Makoto Higuchi , Tetsuya Suhara.
- Organizer
  10th Human Amyloid Imaging
- Place of Presentation
  Miami, USA
- Year and Date
  2016-01-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Conformational heterogeneity of tau lesions captured by PET and its clinical significance2016
- Author(s)
  樋口真人
- Organizer
  14th International Athens/Springfield Symposium on Advances in Alzheimer Therapy
- Place of Presentation
  Athens, Greece
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Conformational heterogeneity of tau lesions captured by PET and its clinical significance2016
- Author(s)
  Makoto Higuchi , Hitoshi Shimada , Naruhiko Sahara , Tetsuya Suhara
- Organizer
  14th International Athens/Springfield Symposium
- Place of Presentation
  Hilton Athens Hotel
- Year and Date
  2016-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Conformational heterogeneity of tau lesions captured by PET and its clinical significance2016
- Author(s)
  樋口真人
- Organizer
  14th International Athens/Springfield Symposium on Advances in Alzheimer Therapy
- Place of Presentation
  Athens, Greece
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Development of PBB32016
- Author(s)
  樋口真人
- Organizer
  Tau PET Futures Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-10-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] Tau imaging and neurodegeneration2016
- Author(s)
  樋口真人
- Organizer
  6th International Society of Radiation Neurobiology Conference
- Place of Presentation
  長崎県長崎市
- Year and Date
  2016-02-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Tau imaging and neurodegeneration2016
- Author(s)
  樋口真人
- Organizer
  6th International Society of Radiation Neurobiology Conference
- Place of Presentation
  長崎県長崎市
- Year and Date
  2016-02-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症タウイメージングの進歩2016
- Author(s)
  樋口真人
- Organizer
  第2回東西合同脳神経外科認知症研究会
- Place of Presentation
  東京都
- Year and Date
  2016-04-09
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] PBB3 in AD and non-AD tauopathies2016
- Author(s)
  樋口真人
- Organizer
  Tau PET Futures Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-10-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 変性型認知症の分子イメージング2016
- Author(s)
  樋口真人, 島田斉, 田桑弘之, 佐原成彦, 須原哲也
- Organizer
  第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 認知症の克服に向けた核医学の貢献2016
- Author(s)
  樋口真人, 島田斉, 木村泰之, 佐原成彦, 堀口隆司, 須原哲也
- Organizer
  第56回日本核医学会学術総会・第36回日本核医学技術学会総会学術大会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2016-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] アルツハイマー病の臨床診断～画像検査とバイオマーカー～2016
- Author(s)
  樋口真人
- Organizer
  第46回日本神経精神薬理学会年会
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-16H05324
[Presentation] 認知症イメージングのこれから：次世代イメージングで何が分かるか2015
- Author(s)
  樋口真人
- Organizer
  第4回東北信神経変性疾患治療研究会
- Place of Presentation
  長野県長野市
- Year and Date
  2015-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Imaging tau: lessons learned relevant to alpha-synuclein imaging2015
- Author(s)
  樋口真人
- Organizer
  Workshop on In Vivo Molecular Imaging of alpha-synuclein
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-12-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] New neuroimaging tools for FTD syndromes and their clinical application2015
- Author(s)
  樋口真人
- Organizer
  Asia pacific FTD & MND Meeting
- Place of Presentation
  Sydney, Australia
- Year and Date
  2015-10-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症分子病理の生体画像化2015
- Author(s)
  樋口真人
- Organizer
  第29回日本医学会総会
- Place of Presentation
  京都府京都市
- Year and Date
  2015-04-12
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Neuroimaging-based biomarkers of neurodegenerative dementias2015
- Author(s)
  樋口真人
- Organizer
  World Engineering Conference and Convention 2015
- Place of Presentation
  京都府京都市
- Year and Date
  2015-12-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症分子病理の生体画像化2015
- Author(s)
  樋口真人
- Organizer
  第29回日本医学会総会
- Place of Presentation
  京都府京都市
- Year and Date
  2015-04-12
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症モデル動物開発とイメージングバイオマーカー開発の相互促進2015
- Author(s)
  樋口真人
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森県青森市
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Novel proteinopathy based tracers for diagnosis2015
- Author(s)
  樋口真人
- Organizer
  19th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-06-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症におけるタウイメージング2015
- Author(s)
  樋口真人
- Organizer
  新潟県脳機能解析研究会
- Place of Presentation
  新潟県新潟市
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症タウタンパク病変の生体イメージング2015
- Author(s)
  樋口真人
- Organizer
  第7回名古屋分子標的イメージングセミナー
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-02-06
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症イメージングのこれから：次世代イメージングで何が分かるか2015
- Author(s)
  樋口真人
- Organizer
  第4回東北信神経変性疾患治療研究会
- Place of Presentation
  長野県長野市
- Year and Date
  2015-11-20
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] [11C]PBB3 PETによるMAPT遺伝子変異症例のタウイメージング2015
- Author(s)
  篠遠　仁 , 佐原　成彦 , 島田　斉 , Wszorek, Z. , 池内　健 , 羽生　春夫 , 石井　賢二 , 樋口　真人 , 須原　哲也
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森、ホテル青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Clinical significance of tau accumulation assessed by [11C]PBB3 PET in diverse tauopathies2015
- Author(s)
  島田　斉 , 須原　哲也 , 篠遠　仁 , 平野　成樹 , 山田　真希子 , 木村　泰之 , 佐原　成彦 , 張　明栄 , 伊藤　浩 , 樋口　真人 , 桑原　聡.
- Organizer
  2015 World Molecular Imaging Congress
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Imaging tau: lessons learned relevant to alpha-synuclein imaging2015
- Author(s)
  樋口真人
- Organizer
  Workshop on In Vivo Molecular Imaging of alpha-synuclein
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-12-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Progressive supranuclear palsy患者における臨床症候と[11C]-PBB3 PET集積の関係2015
- Author(s)
  遠藤　浩信 , 島田　斉 , 篠遠　仁 , 丹羽　文俊 , 北村　聡一郎 , 平野　成樹 , 古川　彰吾 , 樋口　真人 , 須原　哲也
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Novel proteinopathy based tracers for diagnosis2015
- Author(s)
  樋口真人
- Organizer
  19th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-08-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Tau accumulation in patients with MAPT gene mutation measured by [11C]PBB3 PET.2015
- Author(s)
  Hitoshi Shinotoh , Hitoshi Shimada , Wszolek Zbigniew , Takeshi Ikeuchi , Fumitoshi Niwa , Hironobu Endo , Soichiro Kitamura , Shigeki Hirano , Shunsuke Koga , Naruhiko Sahara , Dickson Dennis , Makoto Higuchi , Tetsuya Suhara.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] 認知症モデル動物開発とイメージングバイオマーカー開発の相互促進2015
- Author(s)
  樋口真人
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森県青森市
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Recent advances in clinical tau PET imaging with [11C]PBB32015
- Author(s)
  島田　斉 , 篠遠　仁 , 遠藤　浩信 , 古賀　俊介 , 北村　聡一郎 , 丹羽　文俊 , 石川　愛 , 平野　成樹 , 木村　泰之 , 市瀬　正則 , 山田　真希子 , 佐原　成彦 , 樋口　真人 , 須原　哲也.
- Organizer
  千葉大神経内科教室例会
- Place of Presentation
  オークラ千葉ホテル
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] 認知症タウタンパク病変の生体イメージング2015
- Author(s)
  樋口真人
- Organizer
  第7回名古屋分子標的イメージングセミナー
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-02-06
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 11C-PBB3を用いたタウ病変のPET定量解析2015
- Author(s)
  木村　泰之 , 市瀬　正則 , 伊藤　浩 , 島田　斉 , 生駒　洋子 , 関　千江 , 高野　晴成 , 北村　聡一郎 , 篠遠　仁 , 須原　哲也 , 樋口　真人.
- Organizer
  第55回日本核医学会学術総会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] The analyze of four pedigrees with MAPT N279K mutation accompanying DAT scan and Tau imaging2015
- Author(s)
  Aya Manabe , Kenya Nishioka , Yuanzhe Li , Hiroyo Yoshino , Manabu Funayama , Takashi Matsushima , Shinichi Ueno , Naohide Kurita , Hitoshi Shimada , Naruhiko Sahara , Makoto Higuchi , Tetsuya Suhara , Yuji Ueno , Masashi Takanashi , Yumiko Motoi , Nobutaka Hattori.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] 認知症におけるタウイメージング2015
- Author(s)
  樋口真人
- Organizer
  新潟県脳機能解析研究会
- Place of Presentation
  新潟県新潟市
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Parametric visualisation and quantification of tau pathology in human brain using PET with [C-11]PBB32015
- Author(s)
  木村　泰之 , 市瀬　正則 , 生駒　洋子 , 島田　斉 , 関　千江 , 北村　聡一郎 , 篠遠　仁 , 伊藤　浩 , 須原　哲也 , 樋口　真人.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging annual meeting 2015
- Place of Presentation
  Baltimore, MD, USA
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] 高血圧症はアルツハイマー型認知症のタウ蓄積に寄与するか？～PET画像を用いた検討2015
- Author(s)
  丹羽　文俊 , 島田　斉 , 篠遠　仁 , 遠藤　浩信 , 北村　聡一郎 , 平野　成樹 , 古川　彰吾 , 樋口　真人 , 須原　哲也.
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Tracking tau pathogenesis in living brains2015
- Author(s)
  樋口真人
- Organizer
  9th International Congress of the Asian Society Against Dementia
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-09-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Tracking tau pathogenesis in living brains2015
- Author(s)
  樋口真人
- Organizer
  9th International Congress of the Asian Society Against Dementia
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-09-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Neuroimaging-based biomarkers of neurodegenerative dementias2015
- Author(s)
  樋口真人
- Organizer
  World Engineering Conference and Convention 2015
- Place of Presentation
  京都府京都市
- Year and Date
  2015-12-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] タウPETの現状2015
- Author(s)
  樋口真人
- Organizer
  アルツハイマー病研究会画像診断サブコミッティ2015
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-02-07
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] New neuroimaging tools for FTD syndromes and their clinical application2015
- Author(s)
  樋口真人
- Organizer
  Asia-Pacific FTD & MND Meeting
- Place of Presentation
  Sydney, Australia
- Year and Date
  2015-10-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] タウPETの現状2015
- Author(s)
  樋口真人
- Organizer
  アルツハイマー病研究会画像診断サブコミッティ2015
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-02-07
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Brain metabolic correlates of tau accumulation in progressive supranuclear palsy2015
- Author(s)
  Shogo Furukawa , Shigeki Hirano , Hitoshi Shimada , Hitoshi Shinotoh , Naruhiko Sahara , Hironobu Endo , Soichiro Kitamura , Fumitoshi Niwa , Keisuke Takahata , Yasuyuki Kimura , Makiko Yamada , Ming-Rong Zhang , Hiroshi Ito , Makoto Higuchi , Satoshi Kuwabara , Tetsuya Suhara
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟コンベンションセンター)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Diagnostic utility and clinical significance of tau PET imaging with 11C-PBB32015
- Author(s)
  Hitoshi Shimada , Hitoshi Shinotoh , Naruhiko Sahara , Shigeki Hirano , Shogo Furukawa , Hironobu Endo , Soichiro Kitamura , Fumitoshi Niwa , Keisuke Takahata , Yasuyuki Kimura , Makiko Yamada , Yasumasa Yoshiyama , Ming-Rong Zhang , Hiroshi Ito , Makoto Higuchi , Satoshi Kuwabara , Tetsuya Suhara
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ新潟コンベンションセンター
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26713031
[Presentation] Brain imaging of microglial activation in neurodegeneration2014
- Author(s)
  Higuchi M
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-12
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症タウ病態の解明と画像化2014
- Author(s)
  樋口真人
- Organizer
  第10回関西・中部認知症研究会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2014-02-22
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Imaging distinct strains of tau fibrils in Alzheimer's disease and related neurodegenerative disorders2014
- Author(s)
  Higuchi M, Shimada H, Sahara N, Maruyama M, Shinotoh H, Zhang MR, Suhara T.
- Organizer
  Brain Conference 2014
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-11-07
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Translational Molecular Imaging of Alzheimer's disease and related neurodegenerative disorders2014
- Author(s)
  Higuchi M
- Organizer
  Neurocentrum Ulm
- Place of Presentation
  Ulm, Germany
- Year and Date
  2014-12-08
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症病態と神経炎症のインビボイメージング2014
- Author(s)
  樋口真人
- Organizer
  第26回日本脳循環代謝学会総会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Imaging diverse tau fibril strains in tauopathies2014
- Author(s)
  Higuchi M, Shimada H, Sahara N, Maruyama M, Shinotoh H, Zhang MR, Suhara T.
- Organizer
  9th International Conference on Frontotemporal Dementias
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症タウ病変のイメージング2014
- Author(s)
  樋口真人, 島田斉, 丸山将浩, 佐原成彦, 篠遠仁, 平野成樹, 小野麻衣子, 張明栄, 須原哲也.
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症病態と神経炎症のインビボイメージング2014
- Author(s)
  樋口真人
- Organizer
  第26回日本脳循環代謝学会総会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症タウイメージングの進歩2014
- Author(s)
  樋口真人
- Organizer
  第38回多摩田園臨床精神医学研究会
- Place of Presentation
  神奈川県川崎市
- Year and Date
  2014-02-28
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 神経変性を見る-分子イメージングの現在と展望2014
- Author(s)
  樋口真人
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-13
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Imaging diverse tau fibril strains in tauopathies2014
- Author(s)
  Higuchi M, Shimada H, Maruyama M, Shinotoh H, Zhang MR, Suhara T.
- Organizer
  9th International Conference on Frontotemporal Dementias
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 脳タンパク老化の個別モニタリングを目指した生体イメージング2014
- Author(s)
  樋口真人
- Organizer
  第14回日本抗加齢医学会総会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2014-06-07
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 神経病理の分子イメージングの診療における展望2014
- Author(s)
  樋口真人
- Organizer
  第20回近畿老年期認知症研究会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2014-07-05
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Brain imaging of microglial activation in neurodegeneration2014
- Author(s)
  Higuchi M
- Organizer
  18th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2014-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 神経変性を見る-分子イメージングの現在と展望2014
- Author(s)
  樋口真人
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Tau PET imaging in animal models and humans2014
- Author(s)
  Higuchi M, Shimada H, Sahara N, Suhara T.
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-07-16
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Translational molecular imaging of Alzheimer's disease and related neurodegenerative disorders2014
- Author(s)
  Higuchi M.
- Organizer
  Neurocentrum Ulm
- Place of Presentation
  Ulm, Germany
- Year and Date
  2014-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 神経病理の分子イメージングの診療における展望2014
- Author(s)
  樋口真人
- Organizer
  第28回老年期認知症研究会
- Place of Presentation
  東京都港区
- Year and Date
  2014-07-26
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] オートファジー関連因子p62のタウ病態への関与2014
- Author(s)
  小野麻衣子, 樋口真人, 他
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 神経病理の分子イメージングの診療における展望2014
- Author(s)
  樋口真人
- Organizer
  第28回老年期認知症研究会
- Place of Presentation
  東京都港区
- Year and Date
  2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 脳タンパク老化の個別モニタリングを目指した生体イメージング2014
- Author(s)
  樋口真人
- Organizer
  第14回日本抗加齢医学会総会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2014-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 神経病理の分子イメージングの診療における展望2014
- Author(s)
  樋口真人
- Organizer
  第20回近畿老年期認知症研究会
- Place of Presentation
  大阪府大阪市
- Year and Date
  2014-07-05
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症タウ病変のイメージング2014
- Author(s)
  樋口真人, 島田斉, 丸山将浩, 佐原成彦, 篠遠仁, 平野成樹, 小野麻衣子, 張明栄, 須原哲也.
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-30
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 脳病態とグリア細胞活性化の生体イメージング2014
- Author(s)
  樋口真人
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  栃木県下野市
- Year and Date
  2014-03-29
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] オートファジー関連因子p62のタウ病態への関与2014
- Author(s)
  小野麻衣子, 樋口真人, 他.
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Tau PET imaging in animal models and humans2014
- Author(s)
  Higuchi M, Shimada H, Sahara N, Suhara T.
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Aβ deposition in amyloid precursor protein transgenic mice.2013
- Author(s)
  Chie Seki, Makoto Higuchi, Masaki Tokunaga, Masahiro Murayama, Maiko Ono, Bin Ji,
- Organizer
  11th International Conference on Quantification of Brain Function with PET
- Place of Presentation
  Shanghai International Convention Center Shanghai, China.
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] アルツハイマー病における神経炎症関連分子の生体イメージング2013
- Author(s)
  季　斌, 樋口　真人, 須原　哲也
- Organizer
  第32回日本認知症学会
- Place of Presentation
  長野県松本市
- Year and Date
  2013-11-08
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] アルツハイマー病モデルマウス脳切片を用いた[11C]PIBの異なるアミロイドβ蓄積病理への結合評価2013
- Author(s)
  関　千江, 小野　麻衣子, 季　斌, 徳永　正希, 丸山　将浩, 須原　哲也, 樋口　真人, 伊藤　浩
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡国際会議場、福岡市
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Abeta deposition in amyloid precursor protein transgenic mice2013
- Author(s)
  Seki C, Higuchi M, Tokunaga M, Maruyama M, Ono M, Jin B, Maeda J, Nitta N, Aoki I, Suhara T, Ito H
- Organizer
  XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] PET Imaging of Tau Pathology in Alzheimer's Disease and Related Neurodegenerative Disorders2013
- Author(s)
  Higuchi M
- Organizer
  Annual Congress of the European Association of Nuclear Medicine 2013
- Place of Presentation
  Lyon, France
- Year and Date
  2013-10-23
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Abeta deposition in amyloid precursor protein transgenic mice.2013
- Author(s)
  Seki　C, Higuchi M, Tokunaga M, Maruyama M, Ono M, Jin B, Maeda J, Nitta N, Aoki I, Suhara T, Ito H
- Organizer
  XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function.
- Place of Presentation
  Shanghai International Convention Center, Shanghai, China
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] Role of inflammation in the pathogenesis of Alzheimer's disease2013
- Author(s)
  Higuchi M
- Organizer
  AIGG 2013
- Place of Presentation
  Seoul, Korea
- Year and Date
  2013-06-27
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] アルツハイマー病モデルマウス脳切片を用いた[11C]PIBの異なるアミロイドβ蓄積病理への結合評価2013
- Author(s)
  関千江, 小野麻衣子, 季斌, 徳永正希, 丸山将浩, 須原哲也, 樋口真人, 伊藤浩
- Organizer
  第53回日本核医学会学術総会
- Place of Presentation
  福岡国際会議場, 福岡市
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] IMAGING OF SIGNAL TRANSDUCTION CASCADE IN ALZHEIMER'S DISEASE2013
- Author(s)
  Higuchi M
- Organizer
  BRAIN 2013
- Place of Presentation
  Shanghai, China
- Year and Date
  2013-05-23
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症の分子イメージングにおける新たな展開2012
- Author(s)
  樋口真人
- Organizer
  第10回岡山認知症研究会
- Place of Presentation
  岡山県岡山市
- Year and Date
  2012-10-04
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] アミロイド前駆体蛋白遺伝子導入マウスでのアミロイドβ蓄積と[^<11>C]PIBの動態パラメータの関係2012
- Author(s)
  関千江, 徳永正希, 丸山将浩, 小野麻衣子, 季斌, 前田純, 須原哲也, 樋口真人, 伊藤浩
- Organizer
  第52回日本核医学会学術総会
- Place of Presentation
  ロイトン札幌, 札幌市
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] Molecular and cellular probes for diagnostic and therapeutic assessments of living Alzheimer's disease brains2012
- Author(s)
  Higuchi M
- Organizer
  The 17th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  大阪府吹田市
- Year and Date
  2012-12-06
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] In vivo molecular imaging approaches to the brain environment in neurodegenerative proteinopathies2012
- Author(s)
  Higuchi M
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012)
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2012-09-20
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症創薬とイメージング2012
- Author(s)
  樋口真人
- Organizer
  ゲノム創薬フォーラム第15回シンポジウム
- Place of Presentation
  東京都渋谷区
- Year and Date
  2012-11-02
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Relationship between kinetic parameters of [11C]PIB and amyloidβdeposition studied in amyloid precursor protein transgenic mouse brains2012
- Author(s)
  Seki C, Tokunaga M, Hattori S, Murayama M, Ono M, Ji B, Maeda J, Suhara T, Higuchi M, Ito H
- Organizer
  Neuroreceptor Mapping Congress
- Place of Presentation
  Johns Hopkins University, Baltimore, Maryland, U.S.A
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] タウ病変を標的としたトランスレーショナルリサーチ2012
- Author(s)
  樋口真人
- Organizer
  認知症先進医療開発センター（CAMD）セミナー第二回Expert Seminar Series
- Place of Presentation
  愛知県大府市
- Year and Date
  2012-10-11
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 精神神経疾患におけるシナプスの分子イメージング2012
- Author(s)
  樋口真人、他
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2012-10-26
- Invited
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 認知症創薬に向けた前臨床および臨床分子イメージング2011
- Author(s)
  樋口真人
- Organizer
  第29回理化学研究所ケミカルバイオロジー領域勉強会
- Place of Presentation
  埼玉県和光市(招待講演)
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] アルツハイマー病の分子イメージング～早期診断、病態解明と創薬に向けて～2011
- Author(s)
  樋口真人
- Organizer
  長崎大学第十回地域薬剤師卒後教育研修センター講演会プログラム
- Place of Presentation
  長崎県長崎市(招待講演)
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] アルツハイマー病とミクログリア2011
- Author(s)
  樋口真人
- Organizer
  第52回日本神経学会学術集会
- Place of Presentation
  愛知県名古屋市(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 神経変性ネットワークの生体分子イメージング2011
- Author(s)
  樋口真人
- Organizer
  第7回長寿医療センター国際シンポジウム
- Place of Presentation
  愛知県大府市(招待講演)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Evaluation of regional cerebral blood flow using [^<11>C]PIB in unilateral cerebral hypoperfusion model mice2011
- Author(s)
  Seki C, Higuchi M, Saito S, Tokunaga M, Maruyama M, Okauchi T, Aoki I, Ito H, and Suhara T
- Organizer
  Annual Meeting of Society for Neuroscience 2011
- Place of Presentation
  Washington Covention Center, Washington, D.C., USA
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] Visualization of reciprocal links between inflammation and neurodegenerative pathogenesis in Alzheimer's disease2011
- Author(s)
  Higuchi M
- Organizer
  International Symposium on Inflammation and Disease
- Place of Presentation
  Taipei, Republic of China(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] アルツハイマー病とミクログリア2011
- Author(s)
  樋口真人
- Organizer
  第52回日本神経学会学術集会
- Place of Presentation
  愛知県名古屋市(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] アルツハイマー病の分子イメージング～早期診断、病態解明と創薬に向けて～2011
- Author(s)
  樋口真人
- Organizer
  長崎大学第十回地域薬剤師卒後教育研修センター講演会プログラム
- Place of Presentation
  長崎県長崎市(招待講演)
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 「[11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価」2011
- Author(s)
  関　千江、樋口　真人、齋藤　茂芳、徳永　正希、丸山　将浩、岡内　隆、青木　伊知男、伊藤　浩、須原　哲也
- Organizer
  第５１回日本核医学会学術総会
- Place of Presentation
  つくば国際会議場、つくば市
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] モデル動物の画像病理対応2011
- Author(s)
  樋口真人, 他
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京都江戸川区(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症創薬に向けた前臨床および臨床分子イメージング2011
- Author(s)
  樋口真人
- Organizer
  第29回理化学研究所ケミカルバイオロジー領域勉強会
- Place of Presentation
  埼玉県和光市(招待講演)
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Evaluation of regional cerebral blood flow using [11C]PIB in unilateral cerebral hypoperfusion model mice.2011
- Author(s)
  Seki C, Higuchi M, Saito S, Tokunaga M, Maruyama M, Okauchi T, Aoki I, Ito H, and Suhara T
- Organizer
  Annual Meeting of Society for Neuroscience 2011
- Place of Presentation
  Washington Covention Center, Washington, D.C., USA.
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] [11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価2011
- Author(s)
  関千江, 樋口真人, 齋藤茂芳, 徳永正希, 丸山将浩, 岡内隆, 青木伊知男, 伊藤浩, 須原哲也
- Organizer
  第51回日本核医学会学術総会
- Place of Presentation
  つくば国際会議場, つくば市
- Data Source
  KAKENHI-PROJECT-23591809
[Presentation] 神経変性ネットワークの生体分子イメージング2011
- Author(s)
  樋口真人
- Organizer
  「病態に根ざしたALSの新規治療法開発」ワークショップ
- Place of Presentation
  東京都千代田区(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] タウ病変の生体イメージング2011
- Author(s)
  樋口真人
- Organizer
  第7回長寿医療センター国際シンポジウム
- Place of Presentation
  愛知県大府市(招待講演)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Visualization of reciprocal links between inflammation and neurodegenerative pathogenesis in Alzheimer's disease2011
- Author(s)
  Higuchi M
- Organizer
  International Symposium on Inflammation and Disease
- Place of Presentation
  Taipei, Republic of China(招待講演)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] モデル動物の画像病理対応2011
- Author(s)
  樋口真人, 他
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京都江戸川区(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains.2010
- Author(s)
  C.Seki, M.Higuchi, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, Y.Kimura, I.Kanno, T.Suhara
- Organizer
  The 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
- Place of Presentation
  the Glasgow Hilton Hotel, Glasgow, UK
- Data Source
  KAKENHI-PROJECT-20591469
[Presentation] 核医学の新たな展開2009
- Author(s)
  樋口真人
- Organizer
  第28回日本認知症学会学術集会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2009-11-22
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量2009
- Author(s)
  関千江、徳永正希、服部聡子、志田原美保、中尾隆士、岡内隆、前田純、樋口真人、木村裕一、須原哲也
- Organizer
  第49回日本核医学会学術総会
- Place of Presentation
  旭川市民文化会館・旭川グランドホテル、旭川市
- Data Source
  KAKENHI-PROJECT-20591469
[Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains.2009
- Author(s)
  C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, M.Higuchi, Y.Kimura, T.Suhara
- Organizer
  Annual Meeting of Society for Neuroscience 2009
- Place of Presentation
  McCormick Place, Chicago, Illinois, USA
- Data Source
  KAKENHI-PROJECT-20591469
[Presentation] Advances in the application of imaging-based biomarkers toward therapeutic regulation of amyloid cascade2009
- Author(s)
  Higuchi M
- Organizer
  9th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  プラハ(チェコ)
- Year and Date
  2009-03-14
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] 遺伝子改変モデル動物イメージングに基づく神経老化・神経変性ネットワークモデルの構築2009
- Author(s)
  樋口真人
- Organizer
  第21回日本脳循環代謝学会総会
- Place of Presentation
  大阪府豊中市
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] 神経疾患発病の分子カスケードを追跡する生体イメージング2009
- Author(s)
  樋口真人
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] 神経疾患アミロイド病変の治療制御に向けた生体分子イメージング2008
- Author(s)
  樋口真人
- Organizer
  第8回日本蛋白質科学会年会
- Place of Presentation
  東京都
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] Quantification of 11C-PIB kinetics in mouse brain using metabolite-corrected arterial input function.2008
- Author(s)
  C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, J.Maeda, H.Toyama, T.Irie, M.Higuchi, T.Suhara, I.Kanno, Y.Kimura.
- Organizer
  Nueroreceptor Mapping 2008.
- Place of Presentation
  Omni Penn Hotel, Pittsburgh, PA., USA
- Data Source
  KAKENHI-PROJECT-20591469
[Presentation] アミロイドイメージングの基礎2008
- Author(s)
  樋口真人
- Organizer
  第27回日本認知症学会学術集会
- Place of Presentation
  群馬県前橋市
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] 認知症の分子ネットワーク2008
- Author(s)
  樋口真人
- Organizer
  第48回日本核医学会学術総会
- Place of Presentation
  千葉県千葉市
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20023036
[Presentation] Two faces of activated glia: its deleterious and beneficial effects on Alzheimer's disease captured by noninvasive imaging of amyloidosis and gliosis2007
- Author(s)
  Higuchi M
- Organizer
  The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function (Brain'07)
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-18023040
[Presentation] 精神神経疾患におけるシナプスの分子イメージング
- Author(s)
  樋口真人、他
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  茨城県つくば市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症創薬とイメージング
- Author(s)
  樋口真人
- Organizer
  ゲノム創薬フォーラム第15回シンポジウム
- Place of Presentation
  東京都渋谷区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症の分子イメージングにおける新たな展開
- Author(s)
  樋口真人
- Organizer
  第10回岡山認知症研究会
- Place of Presentation
  岡山県岡山市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Imaging of tau using PET
- Author(s)
  Higuchi M
- Organizer
  Pre-congress Symposium at European Association of Nuclear Medicine Annual Meeting
- Place of Presentation
  Lyon, France
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Translational neuroimaging of Alzheimer’s disease and allied disorders
- Author(s)
  Higuchi M
- Organizer
  International Symposium “New Frontier of Molecular Neuropathology 2014”
- Place of Presentation
  東京都文京区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症タウイメージングの進歩
- Author(s)
  樋口真人
- Organizer
  第38回多摩田園臨床精神医学研究会
- Place of Presentation
  神奈川県川崎市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症イメージングの最前線と将来像
- Author(s)
  樋口真人
- Organizer
  第5回Neuroimaging Seminar
- Place of Presentation
  徳島県徳島市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] In vivo molecular imaging approaches to the brain environment in neurodegenerative proteinopathies
- Author(s)
  Higuchi M
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012)
- Place of Presentation
  愛知県名古屋市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] タウ病変を標的としたトランスレーショナルリサーチ
- Author(s)
  樋口真人
- Organizer
  認知症先進医療開発センター（CAMD）セミナー第二回Expert Seminar Series
- Place of Presentation
  愛知県大府市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] タウイメージングの進歩
- Author(s)
  樋口真人
- Organizer
  第31回日本神経治療学会総会
- Place of Presentation
  東京都文京区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] PETを用いた診断マーカー開発と症候の分子基盤解明
- Author(s)
  樋口真人
- Organizer
  J-CAN 2013
- Place of Presentation
  東京都中央区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] タウイメージングの開発
- Author(s)
  樋口真人
- Organizer
  アルツハイマー病研究会第14回学術シンポジウム
- Place of Presentation
  東京都品川区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Application of PBB compounds to translational research and development targeting tau lesions in Alzheimer's disease
- Author(s)
  Higuchi M
- Organizer
  ADNI2 Private Partner Scientific Board Meeting
- Place of Presentation
  Gaithersburg, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Tau PET
- Author(s)
  Higuchi M
- Organizer
  Establishing Therapeutic Efficacy in Familial Frontotemporal Degeneration
- Place of Presentation
  San Francisco, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Role of inflammation in the pathogenesis of Alzheimer’s disease
- Author(s)
  Higuchi M
- Organizer
  The 20th IAGG World Congress of Gerontology and Geriatrics
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Molecular and cellular probes for diagnostic and therapeutic assessments of living Alzheimer's disease brains
- Author(s)
  Higuchi M
- Organizer
  The 17th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  大阪府吹田市
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] Imaging of signal transduction cascade in Alzheimer's disease
- Author(s)
  Higuchi M
- Organizer
  BrainPET 2013
- Place of Presentation
  Shanghai, China
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[Presentation] 認知症タウ病態の解明と画像化
- Author(s)
  樋口真人
- Organizer
  第10回関西・中部認知症研究会
- Place of Presentation
  大阪市北区
- Invited
- Data Source
  KAKENHI-PROJECT-23390235
[]
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[]

1. SUHARA Tetsuya (90216490)

# of Collaborated Projects: 7 results

# of Collaborated Products: 51 results
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# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
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# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
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# of Collaborated Projects: 1 results

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53. ABE kentaro

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63. 金高秀和

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70. 宮川剛

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77. 谷口直之

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# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
82. 葛原茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGUCHI MAKOTO 樋口 真人

HIGUCHI Makoto 樋口 真人

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Etiological assessments of neurodegenerative dementias by in-vivo imaging of pathological protein aggregates in the brainPrincipal Investigator

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Molecular imaging of neurotoxic signaling in neurodegenerative disordersPrincipal Investigator

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Development of ligands for early diagnosis and mechanistic controls of tauopathiesPrincipal Investigator

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アミロイドカスケードのキープロセス可視化によるアルツハイマー病の診断・治療法開発Principal Investigator

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HIGUCHI MAKOTO 樋口真人

HIGUCHI Makoto 樋口真人