KAWAHARA KOICHI 川原幸一

… Alternative Names

KAWAHARA Koichi 川原幸一

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Researcher Number	10381170
Other IDs	https://orcid.org/0000-0001-8095-3255
Affiliation (Current)	2025: 大阪工業大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2024: 大阪工業大学, 工学部, 教授 2017: 大阪工業大学, 工学部生命工学科, 特任教授 2012 – 2014: 大阪工業大学, 工学部生命工学科, 特任教授 2011 – 2012: 大阪工業大学, 工学部, 特任教授 2011: 大阪工業大学, 工学部・生命工学科機能性食品研究室, 特任教授 … More 2010: 鹿児島大学, 医歯学総合研究科, 助教 2010: 鹿児島大学, 大学院・医歯学総合研究所, 助教 2009: 大阪工業大学, 工学部, 教授 2007 – 2009: 鹿児島大学, 大学院・医歯学総合研究科, 助教 Less
Review Section/Research Field	Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Emergency medicine / Basic Section 59040:Nutrition science and health science-related / Infectious disease medicine / Veterinary medical science / Hematology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 55060:Emergency medicine-related … More / Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Social dentistry / Neurology / Pathological medical chemistry / 膠原病・アレルギー・感染症内科学 / Laboratory medicine Less
Keywords	Principal Investigator 敗血症 / DAMPs / ヒストン / アラーミン / ヌクレオフォスミン / 救急医学 / 炎症 / ワクチン / 予防 / ユビキチン … More / PROTAC / フェノールポリマー / シノビオリン / ユビキチンリガーゼ / ペプチド / αヘリックス / 細胞外ヒストン / 治療ターゲット / 炎症性サイトカイン / 抑制ペプチド / 敗血症治療 / 受容体 / 外科系臨床医学 / オートファジー / インフラマソーム / ファゴサイトーシス / 免疫活性化 / 補体 / thrombomodulin / プラットフォーム分子 / トロンボモジュリン / 集中治療医学 … More Except Principal Investigator HMGB1 / DAMPs / トロンボモジュリン / 敗血症 / DIC / 腫瘍 / PAMPs / ヒストン / DAMPｓ / PAMPｓ / トロンビン / non-coding RNA / 犬 / エクソソーム / ノンコーディングRNA / 細胞外ヒストン / protein C / RAMPs / リウマチ熱 / 溶連菌感染 / キルギス / 乳腺腫瘍 / 肝細胞癌 / メラノーマ / イヌ / microRNA / プロテインC / 集中治療医学 / 敗血症性ショック / 血栓 / TLR-4 / TLR-2 / 炎症 / 糖尿病 / ショック / 細胞・組織 / 感染症 / 蛋白質 / 腸脳相関 / 神経障害性疼痛 / 抗体 / 加齢黄斑変性 / 炎症性サイトカイン / 希少糖 / 網膜色素上皮細胞 / micro vesicles / AI / sncRNA / Y RNA / トランスクリプトーム / 人工知能（AI） / cfDNA / PGC-1α / BDNF / 1,5-anhydro-D-fructose / AMPK / 1,5-AF / 集中治療 / コンドロイチン硫酸 / 播種性血管内凝固症候群 / thrombin / EPCR / Protein C / TM / Thrombomodulin / Thrombin / 修復 / 止血 / 組織損傷 / 生体損傷 / RAMPｓ / small RNA / エキソソーム / イヌ腫瘍 / 診断・治療 / 犬腫瘍 / マイクロRNA / リハビリテーション / 慢性呼吸器疾患 / バイオマス / DAMP / 血栓性微小血管障害症 / von Willebrand因子 / 血管内皮細胞 / 血栓症 / エピジェネティック / HMGB1酸化還元型 / ヒト化モノクローナル抗体 / レドックス状態 / NETs / thrombomodulin / histones / 多臓器不全 / Shock / Histones / Alarmin / 病理学 / 免疫学 / 超音波検査 / 中央アジア / 再興感染症 / 細菌学的検査 / フィールド調査 / p53遺伝子 / リンパ腫 / 遺伝子導入 / 腫瘍治療 / 腫瘍マーカー / 次世代シーケンス / 抗う蝕 / 歯学 / LPS / 歯肉線維芽細胞 / mRNA / 破骨細胞 / 骨破壊抑制 / 抗菌 / 抗炎症 / MK615 / バソプレシン / 血栓形成 / des-HMGB1 / 止血学 / 発現制御 / シグナル伝達 / NF-ｋB / PAR-1 / inflammasome / トロンボモデュリン / mouse / high endothelial venule / lymph node / nervus system / immune system / POEMS syndrome / VEGF-A / angiogenesis / HEV / iron / spleen / lymph / immune / B cell / LPS tolerance / 高内皮小静脈 / B細胞 / リンパ節 / VEGF / 免疫 / 神経 / インスリン抵抗性 / 代謝異常 / 脂質 / 栄養学 / 感染病 / 循環器・高血圧 / T細胞 / 生化学的手法 / E3ユビキチンリガーゼ / 転写制御 / 滑膜細胞増殖 / 化合物 / コンディショナルノックアウトマウス / 滑膜細胞 / 小胞体関連分解 / ユビキチン化 / 分泌 / 滑膜細胞細胞 / サイトカイン / 肝硬変 / アポトーシス / コンディショナルノックアウト / 慢性炎症 / 分泌タンパク質 / 線維化 / シノビオリン / 小胞体ストレス / 関節リウマチ / 侵襲 / IL-1 / CpG DNA / エンドトキシン / alarmin / MOF / degradome / diagnosis / cancer / inflammation / biomarker / peptide / proteome / peptidome / 生体分子 / 酵素 / 検査 / 癌 / 質量分析 / バイオマーカー / ペプチド / ペプチドーム / プロテオーム Less

DAMPsサブタイプ特異的抗体を駆使した敗血症の階層化と分子標的治療技術の構築
- Principal Investigator
  
  伊藤隆史
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kumamoto University
DAMPsワクチンの開発と積極的な予防法の確立とその応用Principal Investigator
- Principal Investigator
  
  川原幸一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
脳腸相関をターゲットとした神経障害性疼痛制御の解明と新規治療薬の開発
- Principal Investigator
  
  芦高恵美子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka Institute of Technology
Elucidating the pathophysiological factors for the clinical application using an artificial intelligence analysis to the snRNA transcriptome data of canine tumors
- Principal Investigator
  
  Miura Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
Development of peptides that regulate DAMPs and their application deployment.Principal Investigator
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
Prevention and Treatment of Age-Related Macular Degeneration by a Novel Functional Monosaccharide with AMPK-regulated Antioxidant Activity
- Principal Investigator
  
  Terasaki Hiroto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagoshima University
Challenging the intracellular degradation of histones through the fusion of new technologies.Principal Investigator
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka Institute of Technology
1,5-AF induces anti-aging effects on aging-associated brain diseases by increasing AMPK activity
- Principal Investigator
  
  Kikuchi Kiyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kurume University
Rapid and specific diagnosis for tumor using exosome and cfDNA
- Principal Investigator
  
  Miura Naoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Kagoshima University
Research on the interaction of histones in pathophysiology of sepsis and its applicationPrincipal Investigator
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
Establishment of smart-diagnosis&treatment for canine tumor by exosome
- Principal Investigator
  
  Miura Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kagoshima University
Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
キルギスでのリウマチ熱蔓延の危険因子の分子疫学的解析と拠点集落でのその制圧の試み
- Principal Investigator
  
  中島利博
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Medical University
The mechamism of novel alarminPrincipal Investigator
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Therapeutic strategy targeting extracellular histones in sepsis-associated DIC
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
The analysis of inflammasome activation in extracellular histonesPrincipal Investigator
- Principal Investigator
  
  Kawahara Ko-ihi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
The receptor and inhibitor of NucleophosminPrincipal Investigator
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Identification of novel canine tumor related microRNA for elucidating the pathology and clinical relevance
- Principal Investigator
  
  Miura Naoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kagoshima University
Integrated molecular medicinal approach for rheumatic heart diseases in Central Asia.
- Principal Investigator
  
  NAKAJIMA TOSHIHIRO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Medical University
Extracellular histones as a myocardial depressant factor
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
HMGB1-induced vaspressin deficiency contributes to septic shock
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Toward the application of MK 615 to dental medicine:Analysis of anti-caries · anti-periodontal disease characteristics
- Principal Investigator
  
  Morimoto Yoko
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Kagoshima University
A role of extracellular histones as mediators of death in sepsis
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Nucleophosmin: immunoactivity as a novel alarminPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Ko-ichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University
DAMPs : novel molecular targets for DIC therapy
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Immunomodulatory effects ofB cell derivedVEGF-A in mice
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kagoshima University
HMGB1の生体内分子修飾による機能変化・病態発現とその制御
- Principal Investigator
  
  丸山征郎
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type moleculePrincipal Investigator
- Principal Investigator
  
  KAWAHARA Ko-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
  Kagoshima University
炎症性の生理活性をもつ“新規アディポサイトカインとしてのHMGB1"の提唱
- Principal Investigator
  
  清水利昭
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
Integrated study on implication of Synoviolin in multiprocesses of rheumatoid arthritis.
- Principal Investigator
  
  NAKAJIMA Toshihiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical University
  Choju Medical Institute, Fukushimura Hospital.
Defense system by thrombin-HMGB1 axis
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University
Diagnostic value of peptidome analyses for protease activated pathological conditions beyond cancer diagnosis
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
壊死細胞由来の核由来生体レスキュー因子:"Alarmins"の概念のスケッチ
- Principal Investigator
  
  丸山征郎
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University

[Book] 別冊BIO Clinica慢性炎症と疾患骨髄-末梢血による炎症の制御と修飾血小板-好中球のサティリティズムと炎症2013
- Author(s)
  大池加恵、川原幸一
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-24659804
[Book] 特集PAMPs/DAMPsと血栓症DIC NETsとヒストンThrombosis medicine 3(4)2013
- Author(s)
  大池加恵、川原幸一
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-24659804
[Book] 特集"自然"炎症と凝固・血小板系のクロストーク(第4回) NETs(Neutorophil Extracellular Traps)と血栓症Thrombosis medicine 2(3)2012
- Author(s)
  上村龍平、川原幸一
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers?Danlos syndrome2023
- Author(s)
  Kamada Hiroki、Emura Kousuke、Yamamoto Rikuto、Kawahara Koichi、Uto Sadahito、Minami Toshiaki、Ito Seiji、Matsumoto Ken-ichi、Okuda-Ashitaka Emiko
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-023-45638-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19544
[Journal Article] 1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis2021
- Author(s)
  Kasamo Yuki、Kikuchi Kiyoshi、Yamakuchi Munekazu、Otsuka Shotaro、Takada Seiya、Kambe Yuki、Ito Takashi、Kawahara Ko-ichi、Arita Kazunori、Yoshimoto Koji、Maruyama Ikuro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 18 Pages: 9941-9941
- DOI
  10.3390/ijms22189941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-21H03037, KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-21K19544
[Journal Article] Protective effects of recombinant human soluble thrombomodulin on ischemia reperfusion injury of spinal cord in rabbits2021
- Author(s)
  Imagama I, Kawahara K, Ueno H, Maruyama I, Imoto H
- Journal Title
  
  Medical Journal of Kagoshima University
  
  Volume: 73 Pages: 16-22
- NAID
  120007001538
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02906
[Journal Article] Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-192020
- Author(s)
  Kanekura Takuro、Kawahara Koichi
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 99 Pages: 1-2
- DOI
  10.1016/j.ijid.2020.07.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02906
[Journal Article] TLR4/MD-2 is a receptor for extracellular nucleophosmin 12020
- Author(s)
  Nakatomi Kota、Ueno Hikari、Ishikawa Yuto、Salim Ronny、Mori Yuki、Kanemoto Issey、Tancharoen Salunya、Kikuchi Kiyoshi、Miura Naoki、Omori Taketo、Okuda?ashitaka Emiko、Matsumura Kiyoshi、Imaizumi Hitoshi、Motomiya Yoshihiro、Maruyama Ikuro、Kawahara Ko-Ichi
- Journal Title
  
  Biomedical Reports
  
  Volume: 14 Issue: 2 Pages: 1-6
- DOI
  10.3892/br.2020.1397
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-18H02906
[Journal Article] E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model2020
- Author(s)
  Kikuchi Kiyoshi、Setoyama Kentaro、Takada Seiya、Otsuka Shotaro、Nakanishi Kazuki、Norimatsu Kosuke、Tani Akira、Sakakima Harutoshi、Kawahara Ko-ichi、Hosokawa Kazuya、Kiyama Ryoji、Sumizono Megumi、Tancharoen Salunya、Maruyama Ikuro、Hattori Gohsuke、Morioka Motohiro、Tanaka Eiichiro、Uchikado Hisaaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3972-3972
- DOI
  10.3390/ijms21113972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-18K08955
[Journal Article] Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.2018
- Author(s)
  Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T,Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, YamamotoM, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 15844-15844
- DOI
  10.1038/s41598-018-34220-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-18H02906, KAKENHI-PROJECT-16K10746
[Journal Article] Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model.2018
- Author(s)
  Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara KI, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 19(5) Issue: 5 Pages: 1-9
- DOI
  10.3390/ijms19051513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-18H02906, KAKENHI-PROJECT-16K10746
[Journal Article] Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.2017
- Author(s)
  Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K,Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: Article ID 6873281 Issue: 1 Pages: 14-14
- DOI
  10.1155/2017/6873281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-15H05684
[Journal Article] Phylogenetic analysis of enteroaggregative Escherichia coli (EAEC) isolates from Japan reveals emergence of CTX-M-14-producing EAEC O25:H4 clones related to sequence type 131.2016
- Author(s)
  Imuta N, Ooka T, Seto K, Kawahara R, Koriyama T, Kojyo T, Iguchi A, Tokuda K, Kawamura H, Yoshiie K, Ogura Y, Hayashi T, Nishi J
- Journal Title
  
  J Clin Microbiol
  
  Volume: 54（8） Issue: 8 Pages: 2128-2134
- DOI
  10.1128/jcm.00711-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-26461589, KAKENHI-PROJECT-16H06279
[Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK615.2015
- Author(s)
  Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
- Journal Title
  
  Medical Hypotheses
  
  Volume: 85 Issue: 5 Pages: 618-621
- DOI
  10.1016/j.mehy.2015.07.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24593161, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293387
[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015
- Author(s)
  Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
- Journal Title
  
  EMBO J.
  
  Volume: 34 Issue: 8 Pages: 1042-55
- DOI
  10.15252/embj.201489897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293385
[Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015
- Author(s)
  Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 2 Pages: e0117775-e0117775
- DOI
  10.1371/journal.pone.0117775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670790, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-25460498
[Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats.2014
- Author(s)
  Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 7 Pages: e102482-e102482
- DOI
  10.1371/journal.pone.0102482
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-25293192, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670793
[Journal Article] Upregulation of non-β Cell-derived Vascular Endothelial Growth FactorA Increases Small Clusters of Insulin producing Cells in the Pancreas.2014
- Author(s)
  Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga M, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K-I, Sakamoto T, Maruyama I, Hashiguchi T.
- Journal Title
  
  Experimental and Clinical Endocrinology & Diabetes
  
  Volume: in press Issue: 05 Pages: 308-15
- DOI
  10.1055/s-0034-1371811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293130
[Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, Irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.2013
- Author(s)
  Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, MaruyamaI, Murai Y, Tanaka E
- Journal Title
  
  Int. Mol. Sci.
  
  Volume: 14 Issue: 9 Pages: 18899-18924
- DOI
  10.3390/ijms140918899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590269, KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25305032
[Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.2013
- Author(s)
  Nakahara M, Ito T, et al.
- Journal Title
  
  PLoS One
  
  Volume: 8(9) Issue: 9 Pages: 75961-75961
- DOI
  10.1371/journal.pone.0075961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659700, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-25670764
[Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2013
- Author(s)
  Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 30(1) Issue: 1 Pages: 28-33
- DOI
  10.1007/s10014-012-0095-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25305032
[Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.2013
- Author(s)
  Shrestha C, Ito T, Kawahara K, Shrestha B, Yamakuchi M, Hashiguchi T, Maruyama I.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 437 Pages: 573-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25305032
[Journal Article] Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke.2013
- Author(s)
  Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, Maruyama I, Murai Y, Tanaka
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 14 Pages: 18899-18924
- Data Source
  KAKENHI-PROJECT-24593161
[Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3 : a Possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.2013
- Author(s)
  Shrestha C, Ito T, et al.
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 437(4) Issue: 4 Pages: 573-578
- DOI
  10.1016/j.bbrc.2013.06.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25670764
[Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism2013
- Author(s)
  Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
- Journal Title
  
  PLoS One
  
  Volume: 8(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670763
[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012
- Author(s)
  Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
- Journal Title
  
  Atherosclerosis
  
  Volume: 224(2) Pages: 511-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2012
- Author(s)
  Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara KI, Maruyama I, Arita K
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012
- Author(s)
  Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
- Journal Title
  
  Clin Exp Dermatol
  
  Volume: 37 Pages: 241-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Efficacy of MK615 for the treatment of patients with liver disorders2012
- Author(s)
  Hokari A, Ishikawa T, Tajiri H, Matsuda T, Ishii O, Matsumoto N, Okuse C, Takahashi H, Kurihara T, Kawahara K, Maruyama I, Zeniya M
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18(31) Issue: 31 Pages: 4118-26
- DOI
  10.3748/wjg.v18.i31.4118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012
- Author(s)
  Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
- Journal Title
  
  Clin Exp Dermatol
  
  Volume: 37(3) Issue: 3 Pages: 241-4
- DOI
  10.1111/j.1365-2230.2011.04181.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] MK615, a Prunus mume Steb. Et Zucc('Ume') Extract, Attenuates the Growth of A375 Melanoma Cells by Inhibiting the ERK1/2-Id-1 Pathway2012
- Author(s)
  Tada KI, Kawahara KI, Matsushita S
- Journal Title
  
  Phytotherapy Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Secondary prevention of stroke : Pleiotropic effects of optimal oral pharmacotherapy2012
- Author(s)
  Kikuchi K, Kawahara K, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, Tanaka E
- Journal Title
  
  Exp Ther Med
  
  Volume: 4(1) Pages: 3-7
- URL
  http://www.spandidos-publications.com/etm/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway2012
- Author(s)
  Tada K, Kawahara K, Matsushita S, Hashiguchi T, Maruyama I, Kanekura T
- Journal Title
  
  Phytother Res
  
  Volume: 26(6) Pages: 833-838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus.2012
- Author(s)
  Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 224 Issue: 2 Pages: 511-514
- DOI
  10.1016/j.atherosclerosis.2012.07.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-23790410, KAKENHI-PROJECT-24659804
[Journal Article] MK615, a Prunus mume Steb.Et Zucc (Ume) extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway2012
- Author(s)
  Tada K
- Journal Title
  
  Phytother Res
  
  Volume: (in press) Issue: 6 Pages: 833-838
- DOI
  10.1002/ptr.3645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591438, KAKENHI-PROJECT-22390179, KAKENHI-PROJECT-24659804
[Journal Article] MK615, a Prunus mume Steb.Et Zucc ('Ume') Extract, Attenuates the Growth of A375 Melanoma Cells by Inhibiting the ERK1/2-Id-1 Pathway2012
- Author(s)
  川原幸一
- Journal Title
  
  Phytotherapy Research
  
  Volume: (in press)(未定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] NSAIDs inhibit neovascularization of chroid through HO-1-dpendency pathway2011
- Author(s)
  Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I
- Journal Title
  
  Sakamoto T. Lab Invest
  
  Volume: 91 Pages: 1277-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway2011
- Author(s)
  Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I, Sakamoto T
- Journal Title
  
  Lab Invest
  
  Volume: 91(9) Pages: 1277-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release o f high-mobility group box 12011
- Author(s)
  Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K.
- Journal Title
  
  Shock 2011
  
  Volume: 36(5) Pages: 494-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659491
[Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release of HMGB12011
- Author(s)
  Sugiura, et al
- Journal Title
  
  Shock
  
  Volume: 36(5) Issue: 5 Pages: 494-500
- DOI
  10.1097/shk.0b013e31822f7e58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J09815, KAKENHI-PROJECT-21659436, KAKENHI-PROJECT-22390354, KAKENHI-PROJECT-22592322, KAKENHI-PROJECT-23390412
[Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011
- Author(s)
  Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
- Journal Title
  
  Shock
  
  Volume: 36 Pages: 494-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke2010
- Author(s)
  Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M
- Journal Title
  
  Med Hypotheses
  
  Volume: 75 Pages: 583-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] The diagnostic value of endothelial function as a potential sensor of fatigue in health2010
- Author(s)
  Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
- Journal Title
  
  Vasc Health Risk Manag
  
  Volume: 24 Pages: 135-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy2010
- Author(s)
  Oyama Y, Hashiguchi T, Taniguchi N, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, Lotz M, Maruyama I
- Journal Title
  
  Lab Invest
  
  Volume: 90 Pages: 853-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Green tea extract supplement inhibition of HMGB1 release in rats exposed to cigarette smoke2010
- Author(s)
  Saiwichai T, Sangalangkarn V, Kawahara K, Oyama Y, Chaichalotornkul S, Narkpinit S, Harnyuttanakorn P, Singhasivanon P, Maruyama I, Tancharoen S
- Journal Title
  
  Southeast Asian J Trop Med Public Health
  
  Volume: 41 Pages: 250-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] 1, 5-Anhydroglucitol attenuates cytokine release and protects mice with type 2 diabetes from inflammatory reactions2010
- Author(s)
  Meng X, Tancharoen S, Kawahara KI, Nawa Y, Taniguchi S, Hashiguchi T, Maruyama I
- Journal Title
  
  Int J Immunopathol Pharmacol
  
  Volume: 23 Pages: 105-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis.2010
- Author(s)
  Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S.
- Journal Title
  
  Spine (Phila Pa 1976). 35(11)
  
  Pages: 1109-1115
- NAID
  10027252218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Advanced malignant melanoma responds to Prunus mume Sieb. Et Zucc (Ume) extract: Case report and in vitro study.2010
- Author(s)
  Matsushita S, Tada KI, Kawahara KI, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
- Journal Title
  
  Exp Ther Med
  
  Volume: 1(4) Pages: 569-574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes.2010
- Author(s)
  Hashiguchi T*, Shrestha B*, Ito T*, Miura N* (*Equal contribution), Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-i Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I
- Journal Title
  
  J Immunol 184
  
  Pages: 4819-4826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390156
[Journal Article] High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis2010
- Author(s)
  Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S
- Journal Title
  
  Spine(Phila Pa 1976)
  
  Volume: 35 Pages: 1109-15
- NAID
  10027252218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB2010
- Author(s)
  Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 397 Pages: 350-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB2010
- Author(s)
  Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 397(2) Pages: 350-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] Involvement of the endocannabinoid system in periodontal healing2010
- Author(s)
  Kozono S, Matsuyama T, Biwasa KK, Kawahara K, Nakajima Y, Yoshimoto T, Yonamine Y, Kadomatsu H, Tancharoen S, Hashiguchi T, Noguchi K, Maruyama I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394 Pages: 928-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes2010
- Author(s)
  Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 4819-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] The diagnostic value of endothelial function as a potential sensor of fatigue in health.2010
- Author(s)
  Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
- Journal Title
  
  Vasc Health Risk Manag 6
  
  Pages: 135-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390156
[Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells2009
- Author(s)
  Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 329 Pages: 865-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells2009
- Author(s)
  Morimoto Y, Kikuchi K, Ito T, Tokuda M, Matsuyama T, Noma S, Hashiguchi T, Torii M, Maruyama I, Kawahara K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 389 Pages: 90-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGB1induced cell death in ischemic neuronal injury in PC12 cells.-2009
- Author(s)
  Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 385(2)
  
  Pages: 132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Attenuation of LPS-induced iNOS expression by 1, 5-anhydro-d-fructose2009
- Author(s)
  Meng X, Kawahara K, Matsushita K, Nawa Y, Shrestha B, Kikuchi K, Sameshima H, Hashiguchi T, Maruyama I
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 387 Pages: 42-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGBlinduced cell death in ischemic neuronal injury in PC12 cells.2009
- Author(s)
  Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 385(2)
  
  Pages: 132-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells2009
- Author(s)
  Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
- Journal Title
  
  J Pharmacol Exp Ther. 329(3)
  
  Pages: 865-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment.2009
- Author(s)
  Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I
- Journal Title
  
  Lab Invest 89
  
  Pages: 278-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390156
[Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009
- Author(s)
  Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T
- Journal Title
  
  Int J Mol Med
  
  Volume: 24 Pages: 605-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells2009
- Author(s)
  Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Morimoto Y, Matsuda F, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Yoshida Y, Tajima Y, Uchikado H, Kuramoto T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 385 Pages: 132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc2009
- Author(s)
  Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK, Nawa Y, Meng X, Oyama Y, Takenouchi K, Shrestha B, Sameshima H, Shimizu T, Adachi T, Adachi M, Maruyama I
- Journal Title
  
  Int J Mol Med
  
  Volume: 23 Pages: 615-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009
- Author(s)
  Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T.
- Journal Title
  
  Int J Mol Med
  
  Volume: 24 Issue: 05 Pages: 605-611
- DOI
  10.3892/ijmm_00000271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-23659176
[Journal Article] Nucleophosmin may act as an alarmin : implications for severe sepsis2009
- Author(s)
  Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T, Masuda Y, Imaizumi H, Hashiguchi T, Maruyama I
- Journal Title
  
  J Leukoc Biol
  
  Volume: 86 Pages: 645-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Diagnostic value of serum peptidome analyses for protease activated pathological conditions beyond cancer diagnosis.2009
- Author(s)
  Hashiguchi T, Tanaka K, Lee LJ, Sasaki K, Natsugoe S, Kawahara K, Arimura K, Maruyama I
- Journal Title
  
  Med Hypotheses 73
  
  Pages: 760-763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390156
[Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.2009
- Author(s)
  Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
- Journal Title
  
  J Pharmacol Exp Ther. 329(3)
  
  Pages: 865-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008
- Author(s)
  Ito T, Kawahara K, Maruyama I, and, et al.
- Journal Title
  
  Arterioscler Thromb Vase Biol. 28(10)
  
  Pages: 1825-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.2008
- Author(s)
  Kawahara K, Hashiguchi T, Maruyama I, et al.
- Journal Title
  
  Int J Mol Med. 22(5)
  
  Pages: 639-644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.2008
- Author(s)
  Kawahara K, Hashiguchi T, Maruyama I, and, et al.
- Journal Title
  
  Int J Mol Med. 22(5)
  
  Pages: 639-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008
- Author(s)
  Ito T, Kawahara K, Maruyama I, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 377(2)
  
  Pages: 642-647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008
- Author(s)
  Ito T, Kawahara K, Maruyama I, et al.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 28(10)
  
  Pages: 1825-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390274
[Journal Article] HMGB1 release in co-cultures of porcine endothelial and human T cells2007
- Author(s)
  Kawahara K, Setoyama K, Maruyama I and, et. al.
- Journal Title
  
  Xenotransplantation. 14(6)
  
  Pages: 636-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659470
[Journal Article] C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.2007
- Author(s)
  Kawahara K, Biswas KK, Maruyama I, et. al.
- Journal Title
  
  Cardiovasc Pathol. 17(3)
  
  Pages: 129-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659470
[Journal Article] HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques.2007
- Author(s)
  Inoue K, Kawahara K, Maruyama I and, et. al.
- Journal Title
  
  Cardiovasc Pathol. 16(3)
  
  Pages: 136-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659470
[Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.
- Author(s)
  Oyama Y, Hashiguchi T, Taniguchi N, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, Lotz M, Maruyama I
- Journal Title
  
  Lab Invest (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390156
[Patent] 歯周病特異的ペプチド、並びにそれを用いた歯周病の治療および診断2010
- Inventor(s)
  丸山征郎, 橋口照人, タンジャルーンサランヤー, 川原幸一, 田中憲次, 李良子
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Number
  2010-061673
- Filing Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-19390156
[Patent] 歯周病特異的ペプチド、並びにそれを用いた歯周病の治療および診断2010
- Inventor(s)
  丸山征郎、橋口照人, タンジャルーンサランヤー, 川原幸一, 田中憲次, 李良子
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Number
  2010-061673
- Filing Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-19390156
[Presentation] アスコピロンP：ERストレス時のCHOPの発現を抑制する2023
- Author(s)
  大谷悠人、上野光理、横井春奈、吉永一浩、室屋賢康、丸山征郎、川原幸一
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19544
[Presentation] アスコピロンP：ERストレス時のCHOPの発現を抑制する2023
- Author(s)
  大谷悠人、上野光理、横井春奈、吉永一浩、室屋賢康、丸山征郎、川原幸一
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H03037
[Presentation] 抗酸化力を高める意義| 術後癒着に備える2021
- Author(s)
  菊池清志, 瀬戸山健太郎, 大塚章太郎, 高田聖也, 中西和毅, 則松貢輔, 谷明, 榊間春利, 川原幸一, 丸山征郎, 田中永一郎, 内門久明
- Organizer
  第18回予防医学会学術総会
- Data Source
  KAKENHI-PROJECT-20K11640
[Presentation] 抗酸化力を高める意義| 脳梗塞の発症・加療に備える2021
- Author(s)
  菊池清志, 瀬戸山健太郎, 大塚章太郎, 高田聖也, 中西和毅, 則松貢輔, 谷明, 榊間春利, 川原幸一, 丸山征郎, 田中永一郎
- Organizer
  第18回予防医学会学術総会
- Data Source
  KAKENHI-PROJECT-20K11640
[Presentation] 細胞外Nucleophosminの受容体はTLR-4である2020
- Author(s)
  中富康太、董建暉、金本一誠、Ronny Christiadi Salim, 上野光理、Salunya Tancharoen, 菊池清志、伊藤隆史、丸山征郎、川原幸一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] ヒストンH2AとH2BはMD2/ERK1/2を介してTNF-αを誘導する2020
- Author(s)
  上野光理, Ronny Christiadi Salim, 石濱一貴, 朝田成重, 山下侑子, Tancharoen Salunya, 菊池清志, 伊藤隆史, 丸山征郎, 川原幸一
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] 細胞外Nucleophosminの受容体は TLR-4である2020
- Author(s)
  中富康太, 董建暉, 金本一誠, Ronny Christiadi Salim, 上野光理, Salunya Tancharoen, 菊池清志伊藤隆史, 丸山征郎, 川原幸一
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019
- Author(s)
  Hikari Ueno, Kota Nakatomi, Shuto Anan, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara.
- Organizer
  9th International DAMPs and Alarmins Symposium
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019
- Author(s)
  Hikari Ueno, Kota Nakatomi, Shuto Anan, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara
- Organizer
  International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] 細胞外Nucleophosminの受容体はTLR-4である2019
- Author(s)
  中富康太、董建暉、金本一誠、Ronny Christiadi Salim, 上野光理、Salunya Tancharoen, 菊池清志、伊藤隆史、丸山征郎、川原幸一
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] ヒストンH2AとH2BはERK1/2を介してTNF-αを誘導する2019
- Author(s)
  上野光理、中富康太、阿南脩人、Salunya Tancharoen, 菊池清志、伊藤隆史、丸山征郎、川原幸一
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] The extracellular Nucleophosmin Receptor is TLR-42019
- Author(s)
  Kota Nakatomi, Ronny Christiadi Salim, Issey Kanemoto, Hikari Ueno, Dong Jianhui, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara.
- Organizer
  International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] The extracellular Nucleophosmin Receptor is TLR-4.2019
- Author(s)
  Kota Nakatomi, Ronny Christiadi Salim, Issey Kanemoto, Hikari Ueno, Dong Jianhui, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara.
- Organizer
  9th International DAMPs and Alarmins Symposium
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019
- Author(s)
  Ueno H, Nakatomi K, Anan S, Tancharoen S, Kikuchi K, Ito T, Maruyama I, Kawahara KI
- Organizer
  9th International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03926
[Presentation] 哺乳類におけるD-アスパラギン酸の生合成機構と抗酸化作用の解析2016
- Author(s)
  武藤菜摘、伊藤智和、邊見久、川邉竜太、川原幸一、吉村徹
- Organizer
  第80回日本生化学会中部支部例会およびシンポジウム
- Place of Presentation
  三重大学講堂（三重県　津市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16H05845
[Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015
- Author(s)
  大池加恵勝野涼太, 藤本靖真, 安田哲, 丸山征郎, 川原幸一
- Organizer
  第３８回日本分子生物学会年会第８８回生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25305032
[Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015
- Author(s)
  大池加恵、勝野涼太、藤本靖真、安田哲丸山征郎、川原幸一
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26670793
[Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1b放出機構の解明2015
- Author(s)
  大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
- Organizer
  第６６回西日本生理学会
- Place of Presentation
  久留米
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25305032
[Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015
- Author(s)
  大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
- Organizer
  西日本生理学会
- Place of Presentation
  久留米
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26670793
[Presentation] キルギス共和国における溶連菌感染症ならびにその合併症であるリウマチ性心疾患/リウマチ熱の現状―9年間のフィールド調査について―Study of Rheumatic Fever /Rheumatic Heart Diseases in Kyrgyz Republic2015
- Author(s)
  Omurzakov N、三浦直樹、川原幸一、西順一郎、八木下尚子, 荒谷　聡子、中島利博
- Organizer
  海外学術調査フェスタ
- Place of Presentation
  東京外国語大学
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-25305032
[Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015
- Author(s)
  大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
- Organizer
  西日本生理学会
- Place of Presentation
  久留米
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26293387
[Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015
- Author(s)
  大池加恵、勝野涼太、藤本靖真、安田哲丸山征郎、川原幸一
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293387
[Presentation] 全県下で毎年実施している医療関連感染対策アンケート結果－2011～2013年の推移－2014
- Author(s)
  西　順一郎、渡邊真裕子、藺牟田直子、川村英樹、折田美千代、水間良裕、川原元司、吉永正夫、波多江正紀．
- Organizer
  第29回日本環境感染学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25305032
[Presentation] マクロファージにおけるプロスタグランジン合成酵素の誘導2013
- Author(s)
  井上智博、川原幸一、松村潔
- Organizer
  2013年度日本生物高分子学会
- Place of Presentation
  大阪
- Year and Date
  2013-11-20
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] イチゴエキスはHMGB1の放出を抑制する2013
- Author(s)
  大池加恵、上村龍平、丸山征郎、川原幸一
- Organizer
  2013年度日本生物高分子学会
- Place of Presentation
  大阪
- Year and Date
  2013-11-20
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] イチゴの新規機能 : HMGB1放出抑制2012
- Author(s)
  上村龍平、大池加恵、丸山征郎、川原幸一
- Organizer
  第51回日本栄養・食糧学会近畿支部大会
- Place of Presentation
  兵庫
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] イチゴの新規機能 : HMGB1放出抑制2012
- Author(s)
  上村龍平、大池加恵、丸山征郎、川原幸一
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] イチゴの新規機能 : HMGB1放出抑制2012
- Author(s)
  上村龍平、大池加恵、丸山征郎、川原幸一
- Organizer
  第85回生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] Endothelial function as an objective assessment tool of fatigue in healthy individuals2010
- Author(s)
  Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
- Organizer
  ICOHN&ACOHN Joint Conference2010
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19390156
[Presentation] Degradation of non-hemostatic molecules in the state of DIC/MOF2008
- Author(s)
  橋口照人, 川原幸一, 丸山征郎, 李良子, 田中憲次
- Organizer
  第12回エンドトキシン血症救命治療研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390156
[Presentation] DIC/MOFにおける生体内蛋白分解の網羅的解析2007
- Author(s)
  橋口照人, 川原幸一, 丸山征郎, 李良子, 田中憲次
- Organizer
  第13回日本エンドトキシン研究会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-19390156

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KAWAHARA KOICHI 川原 幸一

KAWAHARA Koichi 川原 幸一

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DAMPsワクチンの開発と積極的な予防法の確立とその応用Principal Investigator

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Development of peptides that regulate DAMPs and their application deployment.Principal Investigator

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Challenging the intracellular degradation of histones through the fusion of new technologies.Principal Investigator

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Research on the interaction of histones in pathophysiology of sepsis and its applicationPrincipal Investigator

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The mechamism of novel alarminPrincipal Investigator

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KAWAHARA KOICHI 川原幸一

KAWAHARA Koichi 川原幸一