Hirohama Daigoro 広浜大五郎

Researcher Number	20749353
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2021: 帝京大学, 医学部, 臨床助手 2019 – 2020: 帝京大学, 医学部, 臨床助教 2015 – 2019: 東京大学, 先端科学技術研究センター, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator MR / アルドステロン / ミネラロコルチコイド受容体 / ナノバイオテクノロジー / 高血圧 / Rac1 / ミネラルコルチコイド受容体 / 糖尿病性腎症 / aldosterone / angiotensin … More / pendrin / 食塩欠乏 / 血圧 / 塩分欠乏 / 間在細胞 / 鉱質コルチコイド受容体 / アンジオテンシンII / Pendrin … More Except Principal Investigator 高血圧 / ミネラルコルチコイド / 高血圧学 / コルチゾール / 内科 / DOHaD / ミネラルコルチコイド受容体 / 加齢 / 糖尿病性腎臓病 / 食塩感受性高血圧 / アルドステロン / 腎臓病 / エピジェネティクス / 環境因子 / 糖質コルチコイド / 鉱質コルチコイド / ミネラロコルチコイド受容体 / 腎障害 Less

Development of new treatment for diabetic nephropathy using nanobiotechnologyPrincipal Investigator
- Principal Investigator
  
  Hirohama Daigoro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Teikyo University
  The University of Tokyo
Regulatory mechanism and pathophysiological implication of MR-pendrin pathway by renin-angiotensin-aldosterone systemPrincipal Investigator
- Principal Investigator
  
  Hirohama Daigoro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索
- Principal Investigator
  
  FUJITA Toshiro
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunction
- Principal Investigator
  
  FUJITA Toshiro
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Other

[Book] 医学のあゆみ267号、「Pendrinの血圧・電解質代謝調節作用に関する役割」の項を執筆2018
- Author(s)
  広浜大五郎、藤田敏郎
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17K16074
[Journal Article] From mapping kidney function to mechanism and prediction.2022
- Author(s)
  Hirohama D, Susztak K
- Journal Title
  
  Nat Rev Nephrol
  
  Volume: 18 Issue: 2 Pages: 76-77
- DOI
  10.1038/s41581-021-00512-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17732
[Journal Article] Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.2021
- Author(s)
  Ochiai-Homma F, Kuribayashi-Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, Kawagoe M, Tomomitsu Y, Murakawa M, Asakawa S, Hirohama D, Nagura M, Arai S, Yamazaki O, Tamura Y, Fujigaki Y, Nishikawa T, Shibata S
- Journal Title
  
  Hypertens Res
  
  Volume: 44 Issue: 12 Pages: 1557-1567
- DOI
  10.1038/s41440-021-00710-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-19H03678, KAKENHI-PROJECT-19K17719
[Journal Article] Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded <i>db/db</i> Mice2021
- Author(s)
  Hirohama Daigoro、Nishimoto Mitsuhiro、Ayuzawa Nobuhiro、Kawarazaki Wakako、Fujii Wataru、Oba Shigeyoshi、Shibata Shigeru、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  Hypertension
  
  Volume: 78 Issue: 1 Pages: 82-93
- DOI
  10.1161/hypertensionaha.121.17263
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21596, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-19H03678
[Journal Article] A Ruptured Jejunal Arterial Aneurysm in a Young Woman Undergoing Chronic Hemodialysis Due to Myeloperoxidase-antineutrophil Cytoplasmic Antibody-associated Vasculitis2021
- Author(s)
  Murakawa Masataka、Arai Shigeyuki、Kawagoe Mika、Tomomitsu Yoshihiro、Odajima Kohei、Ueno Masaki、Asakawa Shinichiro、Hirohama Daigoro、Nagura Michito、Yamazaki Osamu、Tamura Yoshifuru、Uchida Shunya、Shibata Shigeru、Fujigaki Yoshihide
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 18 Pages: 2939-2945
- DOI
  10.2169/internalmedicine.6721-20
- NAID
  130008088290
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-09-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17732
[Journal Article] Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice.2021
- Author(s)
  Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T.
- Journal Title
  
  Hypertension
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05788
[Journal Article] PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation2020
- Author(s)
  Hirohama Daigoro、Kawarazaki Wakako、Nishimoto Mitsuhiro、Ayuzawa Nobuhiro、Marumo Takeshi、Shibata Shigeru、Fujita Toshiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 12 Pages: 4433-4433
- DOI
  10.3390/ijms21124433
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-19H03678
[Journal Article] 【水電解質】集合管の生理学　主細胞と間在細胞の協調作用のメカニズム2020
- Author(s)
  柴田茂、広浜大五郎
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 62 Pages: 783-789
- Data Source
  KAKENHI-PROJECT-19K17732
[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020
- Author(s)
  Kawarazaki Wakako、Mizuno Risuke、Nishimoto Mitsuhiro、Ayuzawa Nobuhiro、Hirohama Daigoro、Ueda Kohei、Kawakami-Mori Fumiko、Oba Shigeyoshi、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Pages: 4152-4166
- DOI
  10.1172/jci134431
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-18K08028, KAKENHI-PROJECT-19K22984
[Journal Article] Role of the Ubiquitin Proteasome System in the Regulation of Blood Pressure: A Review2020
- Author(s)
  Yamazaki Osamu、Hirohama Daigoro、Ishizawa Kenichi、Shibata Shigeru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 15 Pages: 5358-5358
- DOI
  10.3390/ijms21155358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17719, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-19H03678, KAKENHI-PROJECT-19K22643
[Journal Article] ミネラルコルチコイド受容体関連高血圧（MR-pendrin系など）2020
- Author(s)
  広浜大五郎、藤田敏郎
- Journal Title
  
  日本臨床増刊
  
  Volume: 78巻増刊号1 Pages: 301-307
- Data Source
  KAKENHI-PROJECT-19K17732
[Journal Article] Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study2019
- Author(s)
  Nishimoto Mitsuhiro、Ohtsu Hiroshi、Marumo Takeshi、Kawarazaki Wakako、Ayuzawa Nobuhiro、Ueda Kohei、Hirohama Daigoro、Kawakami-Mori Fumiko、Shibata Shigeru、Nagase Miki、Isshiki Masashi、Oba Shigeyoshi、Shimosawa Tatsuo、Fujita Toshiro
- Journal Title
  
  Hypertension Research
  
  Volume: 42 Issue: 4 Pages: 514-521
- DOI
  10.1038/s41440-018-0201-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06841, KAKENHI-PROJECT-18K12134, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-17K16075, KAKENHI-PROJECT-17K09736, KAKENHI-PROJECT-18K19533
[Journal Article] Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney2018
- Author(s)
  Uchida K, Tanaka Y, Ichikawa H, Watanabe M, Mitani S, Morita K, Fujii H, Ishikawa M, Yoshino G, Okinaga H, Nagae G, Aburatani H, Ikeda Y, Susa T, Tamamori-Adachi M, Fukusato T, Uozaki H, Okazaki T, Iizuka M
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 314 Issue: 4 Pages: F551-F560
- DOI
  10.1152/ajprenal.00390.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15K19443, KAKENHI-PROJECT-17K16074
[Presentation] 血液透析患者における血清セレン濃度とESA反応性との関連の検討2021
- Author(s)
  安川穂，新井繁幸，奈倉倫人，浅川信一郎，広浜大五郎，山崎修，田村好古，藤垣嘉秀，児玉浩子，内田俊也，柴田茂
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] 血中 Klotho 減少は高カリウム血症の原因となりうる2021
- Author(s)
  河原崎和歌子，鮎澤信宏，広浜大五郎，西本光宏，大庭成喜，丸茂丈史，藤田敏郎
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] Rac1-ミネラルコルチコイド受容体系活性化は糖尿病性腎臓病進展に寄与する2021
- Author(s)
  広浜大五郎、西本光宏、鮎澤信宏、河原崎和歌子、藤井航、大庭成喜、柴田茂、丸茂丈史、藤田敏郎
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] 新たな糖尿病性腎臓病モデルの開発とミネラルコルチコイド受容体の関与の解明2020
- Author(s)
  広浜大五郎
- Organizer
  第56回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] ポドサイトRac1-ミネラルコルチコイド受容体(MR)系活性化は糖尿病性腎臓病進展に寄与する2020
- Author(s)
  広浜大五郎, 西本光宏, 鮎澤信宏, 河原崎和歌子, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] アルドステロン過剰時のPendrin制御とα-ケトグルタル酸2020
- Author(s)
  鮎澤信宏, 広浜大五郎, 西本光宏, 河原崎和歌子, 丸茂丈史, 藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] Activation of Rac1-mineralocorticoid receptor pathway in podocyte contributes to the progression of diabetic kidney disease.2020
- Author(s)
  Daigoro Hirohama
- Organizer
  44th Meeting of the International Aldosterone Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病性腎症に生じたメタボリックメモリー関連遺伝子のDNAメチル化異常2020
- Author(s)
  丸茂丈史, 星野純一, 山内真之, 乳原善文, 河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] 新たな糖尿病性腎臓病モデルの開発とミネラルコルチコイド受容体の関与の解明2020
- Author(s)
  広浜大五郎, 西本光宏, 鮎澤信宏, 河原崎和歌子, 大庭成喜, 柴田茂, 丸茂丈史, 藤田敏郎
- Organizer
  第56回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] ポドサイトRac1-ミネラルコルチコイド受容体(MR)系活性化は糖尿病性腎臓病進展に寄与する2020
- Author(s)
  広浜大五郎
- Organizer
  第63回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症における腎血管性機序の検討2020
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 大庭成嘉, 丸茂丈史, 藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] エピジェネティック尿検査による糖尿病性腎症悪化の診断2019
- Author(s)
  丸茂丈史, 星野純一, 河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 佐藤敦久, 乳原善文, 下澤達雄, 藤田敏郎
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の解明2019
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 森典子, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の解明2019
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] "The mineralocorticoid receptor antagonist Finerenone limits podocyte injury in high-salt loaded db/db mice"2019
- Author(s)
  Daigoro Hirohama
- Organizer
  American Society of Nephrology, Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] ミネラロコルチコイド過剰による食塩感受性高血圧におけるPendrin活性化機構2019
- Author(s)
  鮎澤信宏, 広浜大五郎, 西本光宏, 河原崎和歌子, 丸茂丈史, 藤田敏郎
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17732
[Presentation] ミネラロコルチコイド受容体経路を標的とした糖尿病性腎症の新規治療法開発2019
- Author(s)
  広浜大五郎
- Organizer
  第14回Vascular Biology Innovationに関する研究助成　第14回研究発表会（VBIC）
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Two distinct regulations of pendrin by mineralocorticoid receptor in distal nephron2019
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Wakako Kawarazaki, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 44th International Aldosterone Conference,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediated RAAS-driven pendrin regulation to maintain fluid homeostasis2018
- Author(s)
  Ayuzawa Nobuhiro, Nishimoto Mitsuhiro, Hirohama Daigoro, Ueda Kohei, Kawarazaki Wakako, Shimosawa Tastuo, Marumo Takeshi, Fujita Toshiro
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・水電解質代謝調節作用に関する検討2018
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第22回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第54回高血圧関連疾患学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates RAAS-driven pendrin regulation to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita.
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] High salt diet increases Prostaglandin E2 synthesis through oxidative stress2018
- Author(s)
  Reheman Latapati, 森典子, 広浜大五郎, 小倉彩世子, 王聡慧, Alimila Yeerbolati, Liu Beibei, 藤田敏郎, 矢冨裕, 下澤達雄
- Organizer
  第22回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の検討2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、丸茂丈史、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症におけるKlotho-Wnt-Rho pathwayの関与2018
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 森典子, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 加齢に伴う食塩感受性高血圧発症におけるKlotho-Wnt-Rho pathwayの関与2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、森典子、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的DNAメチル化を尿中マーカーとした糖尿病性腎症の尿細管障害診断法2018
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、佐藤敦久、渥美義仁、星野純一、乳原善文、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の検討2018
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 丸茂丈史, 藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells2018
- Author(s)
  Oba Shigeyoshi, Ayuzawa Nobuhiro, Nishimoto Mitsuhiro, Kawarazaki Wakako, Ueda Kohei, Hirohama Daigoro, Kawakami-Mori Fumiko, Shimosawa Tatsuo, Marumo Takeshi, Fujita Toshiro
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto,Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  The 43rd Annual Meeting of the International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第54回高血圧関連疾患学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的DNAメチル化を尿中マーカーとした糖尿病性腎症の尿細管障害診断法2018
- Author(s)
  丸茂丈史, 下澤達雄, 河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 佐藤敦久, 渥美義仁, 星野純一, 乳原善文, 藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates pendrin regulation by renin-angiotensin-aldosterone system to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢と食塩感受性高血圧～抗加齢因子Klotho の発現低下はRhoA 活性化による血管収縮を惹起する～2017
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 上田浩平, 広浜大五郎, 渡邉篤史, 丸茂丈史, 藤田　敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2017
- Author(s)
  西本光宏、上田浩平、河原崎和歌子、水野理介、森典子、渡邉篤史、広浜大五郎、鮎澤信宏、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第90回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2017
- Author(s)
  広浜大五郎, 柴田茂, 上田浩平, 鮎澤信宏, 西本光宏, 河原崎和歌子, 渡邉篤史, 下澤達雄, 丸茂丈史, 藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 特異的DNAメチル化マーカーを用いた糖尿病性腎症の尿細管障害診断2017
- Author(s)
  丸茂丈史, 下澤達雄, 河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 渡邉篤史, 星野純一, 乳原善文, 藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 特異的DNAメチル化signatureを用いた糖尿病性腎症の尿細管障害診断2017
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、星野純一、乳原善文、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klothoの発現低下は腎mTORC1の活性化を介して食塩感受性高血圧を惹起する2017
- Author(s)
  河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢と食塩感受性高血圧～抗加齢因子Klothoの発現低下はRhoA活性化による血管収縮を惹起する～2017
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的な11β-HSD2活性低下による高血圧発症機序の解析2017
- Author(s)
  上田浩平, 西本光宏, 広浜大五郎, 鮎澤信宏, 河原崎和歌子, 渡邉篤史, 下澤達雄, 丸茂丈史, 藤田　敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 腎pendrinの発現機構と血圧調節における役割の解明2017
- Author(s)
  広浜大五郎, 鮎澤信宏, 上田浩平, 西本光宏, 河原崎和歌子, 渡邉篤史, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第21回心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 腎間在細胞ミネラロコルチコイド受容体欠損マウスを用いたPendrin制御機構の解析2017
- Author(s)
  鮎澤信宏, 上田浩平, 広浜大五郎, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2017
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto,Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 糖尿病性腎症で核内受容体PXRはエピゲノム異常をきたし腎臓内糖新生を調節する2017
- Author(s)
  渡邉篤史, 丸茂丈史, 河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 熊谷裕生, 藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 抗加齢因子Klothoの発現低下は腎mTORC1の活性化を介して食塩感受性高血圧を惹起する2017
- Author(s)
  河原崎和歌子, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] 糖尿病腎メサンギウム細胞のDNA メチル化異常によるTGFb 発現増加をRA 系阻害薬は抑制する2017
- Author(s)
  大庭成喜, 広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 上田浩平, 下澤達雄, 丸茂丈史, 藤田　敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K16074
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2017
- Author(s)
  広浜大五郎、柴田茂、上田浩平、鮎澤信宏、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2017
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto,Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Systemic effect of renal 11beta-HSD2 deficiency on blood pressure regulation2017
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Daigoro Hirohama, Nobuhiro Ayuzawa, Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Johannes Loffing, Ming-Zhi Zhang, Takeshi Marumo, Toshiro Fujita
- Organizer
  AHA Council on Hypertension American Society of Hypertension Joint Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎間在細胞ミネラロコルチコイド受容体欠損マウスを用いたPendrin制御機構の解析2017
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的な11beta HSD2活性低下による高血圧発症機序の解析2017
- Author(s)
  上田浩平、西本光宏、広浜大五郎、鮎澤信宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎pendrinの発現機構と血圧調節における役割の解明2017
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第21回心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病腎メサンギウム細胞のDNAメチル化異常によるTGFｂ発現増加をRA系阻害薬は抑制する2017
- Author(s)
  大庭成喜、広浜大五郎、鮎澤信宏、西本光宏、河原崎和歌子、上田浩平、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病性腎症でエピゲノム異常をきたす核内受容体PXRは腎糖新生を調整する2017
- Author(s)
  渡邉篤史丸茂丈史河原崎和歌子西本光宏鮎澤信宏広浜大五郎上田浩平熊谷裕生藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2016
- Author(s)
  広浜大五郎, 柴田茂, 上田浩平, 鮎澤信宏, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 間在細胞EGFP標識マウスを用いた間在細胞分取・解析法の確立2016
- Author(s)
  鮎澤信宏, 上田浩平, 広浜大五郎, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] The mechanism of blood pressure elevation in distal nephron-specific Hsd11b2 knockout mice2016
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Nobuhiro Ayuzawa, Daigoro Hirohama, Atsushi Watanabe, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 41st International Aldosterone Conference Aldosterone and Mineralocorticoids
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralcorticoid receptor responsible for salt induced COX2 expression in renal medulla2016
- Author(s)
  Reheman L, Hirohama D, Koid S S, Wang C, Mori F, Yeerbolati A, Liu B, Yatomi Y, Shimosawa T
- Organizer
  The 26th Scientific meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klotho発現低下に伴う食塩感受性高血圧発症機序の解明2016
- Author(s)
  河原崎和歌子, 丸茂丈史, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 渡邉篤史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 遠位ネフロン特異的Rac1欠損マウスを用いたRac1-ミネラロコルチコイド受容体（MR）経路の解析2015
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Eplerenoneは塩分過剰摂取によるRA系阻害抵抗性腎障害を抑制する−EVALUATE試験サブ解析−2015
- Author(s)
  西本光宏、大津洋、丸茂丈史、河原崎和歌子、鮎澤信宏、上田浩平、広浜大五郎、渡邉篤史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
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1. FUJITA Toshiro (10114125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
2. 河原崎和歌子 (50424594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
3. 鮎澤信宏 (50459517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
4. 柴田茂 (60508068)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. 丸茂丈史 (70265817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
6. 大庭成喜 (80361492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 下澤達雄 (90231365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
8. 西本光宏 (90646572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
9. 上田浩平 (80735697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
10. 森典子 (80431857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 長瀬美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石澤健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirohama Daigoro 広浜 大五郎

Research Projects

Research Products

Co-Researchers

Development of new treatment for diabetic nephropathy using nanobiotechnologyPrincipal Investigator

Principal Investigator

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Research Category

Review Section

Research Institution

Regulatory mechanism and pathophysiological implication of MR-pendrin pathway by renin-angiotensin-aldosterone systemPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ267号、「Pendrinの血圧・電解質代謝調節作用に関する役割」の項を執筆2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] From mapping kidney function to mechanism and prediction.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.2021

Author(s)

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[Journal Article] Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded <i>db/db</i> Mice2021

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[Journal Article] A Ruptured Jejunal Arterial Aneurysm in a Young Woman Undergoing Chronic Hemodialysis Due to Myeloperoxidase-antineutrophil Cytoplasmic Antibody-associated Vasculitis2021

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[Journal Article] Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice.2021

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[Journal Article] PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation2020

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[Journal Article] 【水電解質】集合管の生理学 主細胞と間在細胞の協調作用のメカニズム2020

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[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020

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[Journal Article] Role of the Ubiquitin Proteasome System in the Regulation of Blood Pressure: A Review2020

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Hirohama Daigoro 広浜大五郎

[Journal Article] 【水電解質】集合管の生理学　主細胞と間在細胞の協調作用のメカニズム2020