Yamashita Fumiyoshi 山下富義

… Alternative Names

YAMASHITA Fumiyoshi 山下富義

山下富義ヤマシタフミヨシ

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Researcher Number	30243041
Other IDs	https://orcid.org/0000-0002-3503-8696
External Links
Affiliation (Current)	2024: 京都大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 京都大学, 薬学研究科, 教授 2011 – 2015: 京都大学, 薬学研究科(研究院), 准教授 2014: 京都大学, 大学院薬学研究科, 准教授 2013 – 2014: 京都大学, 薬学研究科, 准教授 2011 – 2012: 京都大学, 大学院・薬学研究科, 准教授 … More 2007 – 2011: Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor 1998 – 2006: 京都大学, 薬学研究科, 助教授 2000: 京都大学, 薬学研究所, 助教授 1999: 京都大学, 大学院・薬学研究科, 助教授 1997: 京都大学, 大学院・薬学研究科, 助教授 1994: 京都大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Physical pharmacy / Physical pharmacy / Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Complex systems Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 90110:Biomedical engineering-related / Medical pharmacy … More / Biological Sciences / 応用薬理学・医療系薬学 / Medical engineering assessment / Physical pharmacy / Biological pharmacy / 医薬分子機能学 / Applied pharmacology / Biomedical engineering/Biological material science / Complex systems Less
Keywords	Principal Investigator 構造活性相関 / テキストマイニング / 遺伝的アルゴリズム / 薬物代謝 / information visualization / structure-activity relationship / 判別分析 / 情報可視化 / ドラッグデリバリー / 薬物動態 … More / 自然言語処理 / 吸収予測 / 吸収促進剤 / 経皮吸収 / 炎症スパイラル / 炎症性腸疾患 / 腸運動 / 生体模倣デバイス / シミュレーション / 糖代謝疾患 / 臓器チップ / 逆行性輸送 / 小胞体 / 糖鎖 / 細胞内標的指向化 / ドラッグデリバリーシステム / マイクロアレイ解析 / 因子分析 / 転写因子 / 数理モデリング / 抗炎症反応 / ヘパリン誘導体 / discrimination analysis / natural language processing / text mining / drug metabolism / 化合物情報 / 多目的同時最適化 / 階層型データ / 決定木モデル / orally active drugs / P-glycoprotein / drug-likeness / pattern recognition / chemical space / トランスポータ / 化合物超空間 / P糖タンパク質 / 経口医薬品 / P-糖タンパク質 / ドラッグライクネス / 化合物特性空間 / QSAR / Caco-2 cell permeability / solibility / prediction / oral absorption / partial least squares method / genetic algorithm / genetic programming / 部分最小ニ乗法 / 定量的構造活性相関 / Caco-2細胞 / 溶解度 / 消化管吸収 / 部分最小二乗法 / 遺伝的プログラミング / 機械学習 / パラメータ推定 / 母集団解析 / 拡張最小二乗法 / 個体間変動 / 遺伝的数式プログラミング / 共変量モデル / 母集団薬物動態解析 / TLR-4 / 炎症性サイトカイン / マクロファージ / 関節リウマチ / ヘパリンナノ粒子 / 分子間相互作用 / モデル化 / 生理学的モデル / 酵素誘導 / 薬剤反応性 / 生体生命情報学 / 薬物相互作用 / ネットワーク解析 / インシリコ予測 / 自然言語解析 / 薬物間相互作用 / 膜流動性 / 電子スピン共鳴スペクトル法 / 反射赤外吸収スペクトル法 / FTIRスペクトル法 / ESRスペクトル法 / 蛍光異方性 / 細胞膜流動性 / 角質エンベロープ / 角質バリアー / 角質層 / プロドラッグ / 拡散モデル / 溶解度パラメータ / 高速ラプラス逆変換 / 皮膚拡散モデル / 基剤 … More Except Principal Investigator ターゲティング / 遺伝子治療 / ドラッグデリバリーシステム / ドラッグデリバリー / プラスミドDNA / NFκB / DDS / 低分子抗体 / 間葉系幹細胞 / NO / plasmid DNA / gene therapy / 炎症 / 薬物動態学 / リポソーム / 遺伝子デリバリー / 癌 / カチオン性リポソーム / 化学修飾 / カタラーゼ / 活性酸素 / エンドサイトーシス / 体内動態 / 非ウイルスベクター / 肝炎 / 肝線維化治療 / Nrf2 / 喉頭 / 喫煙曝露 / 共培養 / Gut-on-a-chip / Disease-on-a-chip / 腸管免疫 / 炎症性腸疾患 / Organ-on-a-chip / マイクロ流体デバイス / 腸内細菌叢 / HAND / トランスポータ / 脳移行 / 脂溶性 / 有害事象自発報告データベース / HIV関連神経認知障害 / 血液脳関門 / P-gp / BCRP / トランスポーター / インテグラーゼ阻害薬 / 抗HIV薬 / scFv / 安全性評価 / Reactive oxygen / Non-viral vector / Gene therapy / Gene delivery / Plasmid DNA / Drug delivery system / 核移行シグナル / NF-κB / キメラタンパク質 / Biodistribution / Receptor-mediated / Endocytosis / Sugar modification / Liposome / Targeting / Drug delivery / 受容体介在性 / 糖修飾 / antisense oligonucleotide / local administration / drug delivery system / solid tumors / 単離腫瘍灌流実験系 / ヒト腫瘍細胞 / アンチセンスオリゴヌクレオチド / 局所投与 / 固形腫瘍 / tumor necrosis factor / CpG motif / scavenger receptor / cellular uptake / macrophage / DNA vaccination / 活性化 / ポリアニオン / インターロイキン-6 / 腫瘍壊死因子 / CpGモチーフ / スカベンジャー受容体 / 細胞取り込み / マクロファージ / DNAワクチン / skin diffusion model / artificial neural network / molecular orbital calculation / multivariate analysis / activity relationship / quantitative structure / drug absorption / 重回帰分析 / 基剤物性 / 構造動態相関解析 / 経皮吸収 / 皮膚拡散モデル / ニューラルネットワーク / 分子軌道法 / 多変量解析 / 構造活性相関 / 薬物吸収 / 幹細胞 / 遺伝子発現制御 / ナノ粒子 / がん微小環境 / 超音波医科学 / ナノバイオ材料 / 小胞体ストレス / 免疫活性化 / がん治療 / 核酸医療 / 生物学 / 生物物理 / 代謝 / 全身循環 / 薬物動態 / 不整脈 / 心臓 / 生物物理学 / 生理学 / システム生物学 / 非ウィルス性キャリア / プロトンスボンジ効果 / NFkB / 免疫応答 / ポリマー / エンドソーム / サイトカイン / 癌転移 / 高分子ミセル / リボソーム / 活性酸素消去酵素 / がん / CpG / 量子ドット / 腹膜播種 / レチノイン酸誘導体 / 分化誘導量表 / CpGオリゴ / 免疫療法 / 薬物キャリア / イメージング / 癌ターゲティング / 転移性肺癌 / インターフェロン-β / 構造解析 / 原子間力顕微鏡 / X線小角散乱法 / 癌遺伝子治療 / 肝臓 / 受容体介在性エンドサイトーシス / ダブルターゲティング / 肝臓ターゲティング / 虚血再灌流障害 / SOD / 膜融合性ペプチド / 細胞内動態 / キャリアー Less

Elucidation of Inflammatory Mechanisms by Nrf2 Regulation in a Smoking Exposure Model and Development of Novel Therapy for Laryngeal Inflammatory Disease
- Principal Investigator
  
  喜多知子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto University
糖代謝疾患の時間発展評価を目指した仮想現実統合型生体チップモデルの開拓Principal Investigator
- Principal Investigator
  
  山下富義
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyoto University
Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motilityPrincipal Investigator
- Principal Investigator
  
  山下富義
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto University
低分子抗体を用いた幹細胞デリバリーによる肝線維化治療
- Principal Investigator
  
  樋口ゆり子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyoto University
Development of a microfluidic device that mimics inflammatory bowel disease caused by disruption of the intestinal flora
- Principal Investigator
  
  津田真弘
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto University
Targeted delivery of cell medicine by cell surface modification with low molecular weight antibody
- Principal Investigator
  
  Higuchi Yuriko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Kyoto University
Establishment of appropriate management of anti-HIV drugs to suppress the onset of HIV-associated neurocognitive disorder (HAND)
- Principal Investigator
  
  Tsuda Masahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto University
Muti-step targeted drug delivery to endoplasmic reticulum via retrograde transport systemsPrincipal Investigator
- Principal Investigator
  
  Yamashita Fumiyoshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyoto University
Development of safety evaluation system for DDS carrier based on network toxicology
- Principal Investigator
  
  Hashida Mitsuru
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical engineering assessment
- Research Institution
  Kyoto University
Mechanism of anti-inflammatory action of self-assembling heparion nanoparticlesPrincipal Investigator
- Principal Investigator
  
  YAMASHITA FUMIYOSHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Full-automatic PopPK modeling utilizing an evolutionary algorithmPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto University
Integrated analysis of biological interaction of small molecules at the molecular level of living organismsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Therapeutic strategy of drug delivery systems utilizing unique tumor environment
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kyoto University
Development of heparin-based nanoparticles with multi-functional biological properties intended for rheumatoid arthritis therapyPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Establishment of Integrative Multi-level Systems Biology and its Applications
- Principal Investigator
  
  KURACHI YOSHIHISA
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Natural Language Processing-Based Comprehensive Data Analysis for Interaction Between Chemicals and Drug Metabolism NetworkPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
Development of gene carriers based on in vivo and intracellular distribution real-time analysis
- Principal Investigator
  
  MITSURU Hashida
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Natural language processing-based acquisition and analysis of information of drug metabolismPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfection
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Development of Novel Discrimination Model and Its Application to Predicting P-gp SubstratePrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto University
Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface property
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
Genetic Algorithm-Based Optimization of In Silico prediction Models for Oral AbsorptionPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Fumiyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  KYOTO UNIVERSITY
がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発
- Principal Investigator
  
  橋田充
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Development of local drug disposition analysis and delivery methods in human solid tumors
- Principal Investigator
  
  TAKAKURA Yoshinobu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYOTO UNIVERSITY
がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
角質バリアー機能におけるコルネオサイトエンベロープの生物物理学的意義の解明Principal Investigator
- Principal Investigator
  
  山下富義
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
受容体介在性エンドサイトーシスを利用した活性酸素分解酵素のダブルターゲティング
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto University
分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発
- Principal Investigator
  
  HASHIDA Mitsuru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  KYOTO UNIVERSITY
遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立
- Principal Investigator
  
  TAKAKURA Yoshinobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYOTO UNIVERSITY
皮膚内薬物代謝挙動を考慮した総合的経皮吸収動態モデルの確立Principal Investigator
- Principal Investigator
  
  山下富義
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University
拡散モデルに基づく経皮吸収促進法の予測理論の確立:促進効果に及ぼす基剤の影響Principal Investigator
- Principal Investigator
  
  山下富義
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University

[Book] Dr. 北野のゼロから始めるシステムバイオロジー　第10講　PhysioDesignerによる生理機能の多階層モデル構築とシミュレーション2015
- Author(s)
  浅井義之、山下富義
- Publisher
  羊土社
- Data Source
  KAKENHI-PLANNED-23136102
[Book] Dr. 北野のゼロから始めるシステムバイオロジー　第10講　PhysioDesignerによる生理機能の多階層モデル構築とシミュレーション2015
- Author(s)
  浅井義之、山下富義
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25670073
[Book] 薬物体内動態とDDS機能のコンピュータシミュレーション,図解で学ぶDDS(橋田充監修,高倉喜信編)2010
- Author(s)
  山下富義
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-21390008
[Book] In silicoによるバイオアベイラビリティの予測,薬物の消化管吸収予測研究の最前線,(杉山雄一監修)2010
- Author(s)
  山下富義
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-21390008
[Journal Article] Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices2022
- Author(s)
  Sasaki Yuko、Tatsuoka Hirotaka、Tsuda Masahiro、Sumi Takumi、Eguchi Yuka、So Kanako、Higuchi Yuriko、Takayama Kazuo、Torisawa Yusuke、Yamashita Fumiyoshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 9 Pages: 1246-1253
- DOI
  10.1248/bpb.b22-00092
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06642, KAKENHI-PROJECT-21K15313
[Journal Article] CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis2022
- Author(s)
  Zhang Qiyue、Taniguchi Shiori、So Kanako、Tsuda Masahiro、Higuchi Yuriko、Hashida Mitsuru、Yamashita Fumiyoshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 8 Pages: 337-348
- DOI
  10.2131/jts.47.337
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06642, KAKENHI-PROJECT-21K15313
[Journal Article] Application of perfluoropolyether elastomers in microfluidic drug metabolism assays2022
- Author(s)
  Wang Mengyang、Tsuda Masahiro、Deguchi Sayaka、Higuchi Yuriko、So Kanako、Torisawa Yu-suke、Takayama Kazuo、Yamashita Fumiyoshi
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 627 Pages: 122253-122253
- DOI
  10.1016/j.ijpharm.2022.122253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06642, KAKENHI-PROJECT-21K15313, KAKENHI-PROJECT-22KJ1862
[Journal Article] Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes2021
- Author(s)
  Deguchi S, Tsuda M, Kosugi K, Sakamoto A, Mimura N, Negoro R, Sano E, Nobe T, Maeda K, Kusuhara H, Mizuguchi H, Yamashita F, Torisawa Y, Takayama K
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 7 Issue: 8 Pages: 3648-3657
- DOI
  10.1021/acsbiomaterials.1c00642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06642
[Journal Article] Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies2021
- Author(s)
  Sano E, Deguchi S, Matsuoka N, Tsuda M, Wang M, Kosugi K, Mori C, Yagi K, Wada A, Yamasaki S, Kawai T, Yodogawa M, Mizuguchi H, Nakazawa N, Yamashita F, Torisawa Y, Takayama K
- Journal Title
  
  ACS Omega
  
  Volume: 6 Issue: 38 Pages: 24859-24865
- DOI
  10.1021/acsomega.1c03719
- NAID
  120007153093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06642
[Journal Article] Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells2019
- Author(s)
  Chantarasrivong Chanikarn、Higuchi Yuriko、Tsuda Masahiro、Yamane Yuuki、Hashida Mitsuru、Konishi Miku、Komura Naoko、Ando Hiromune、Yamashita Fumiyoshi
- Journal Title
  
  RSC Advances
  
  Volume: 9 Issue: 36 Pages: 20518-20527
- DOI
  10.1039/c9ra01943j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06747, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-18H03531
[Journal Article] A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients2019
- Author(s)
  Ota Ryosaku、Ishii Hiromu、Tsuda Masahiro、Higuchi Yuriko、Yamashita Fumiyoshi
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 25 Issue: 9 Pages: 687-694
- DOI
  10.1016/j.jiac.2019.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06747
[Journal Article] Evaluation of the Theranostic Potential of Perfluorohexane-Based Acoustic Nanodroplets2019
- Author(s)
  Abdalkader R, Unga J, Yamashita F, Maruyama K, Hashida M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 12 Pages: 2038-2044
- DOI
  10.1248/bpb.b19-00525
- NAID
  130007754506
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01861, KAKENHI-PROJECT-18K19939
[Journal Article] Binding and structure-kinetic relationship analysis of selective TLR4-targeted immunosuppressive self-assembling heparin nanoparticles2018
- Author(s)
  Babazada Hasan、Yanamoto Shinya、Hashida Mitsuru、Yamashita Fumiyoshi
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 552 Issue: 1-2 Pages: 76-83
- DOI
  10.1016/j.ijpharm.2018.09.054
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03531
[Journal Article] Dynamic Simulation of Drug-Drug Interactions by Using Multi-level Physiological Modeling & Simulation Platforms2018
- Author(s)
  山下富義
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 3 Pages: 347-351
- DOI
  10.1248/yakushi.17-00191-2
- NAID
  130006410761
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-03-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08071
[Journal Article] The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection2017
- Author(s)
  Abdalkader R, Kawakami S, Unga J, Higuchi Y, Suzuki R, Maruyama K, Yamashita F, Hashida M
- Journal Title
  
  Drug Delivery
  
  Volume: 24 Issue: 1 Pages: 320-327
- DOI
  10.1080/10717544.2016.1250139
- NAID
  120006987449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01861, KAKENHI-PROJECT-17H00864
[Journal Article] Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages2017
- Author(s)
  Yanamoto S, Babazada H, Sakai S, Higuchi Y, Yamashita F, Hashida M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 4 Pages: 540-545
- DOI
  10.1248/bpb.b16-00928
- NAID
  130005530148
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08071
[Journal Article] Modeling and simulation of pharmacokinetic drug-drug interaction caused by induction of metabolic enzymes2016
- Author(s)
  山下富義
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 147 Issue: 2 Pages: 95-100
- DOI
  10.1254/fpj.147.95
- NAID
  130005125654
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001
[Journal Article] Multiple linear regression analysis indicates association of P-glycoprotein substrate or inhibitor character with bitterness intensity, measured with a sensor2015
- Author(s)
  Kentaro Yano, Suzune Mita, Kaori Morimoto, Tamami Haraguchi, Hiroshi Arakawa, Miyako Yoshida, Fumiyoshi Yamashita, Takahiro Uchida, Takuo Ogihara
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 104 Issue: 9 Pages: 2789-2794
- DOI
  10.1002/jps.24232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-24590667, KAKENHI-PROJECT-25670073
[Journal Article] Modeling and prediction of solvent effect on human skin permeability using support vector regression and random forest.2015
- Author(s)
  Hiromi Baba, Jun-ichi Takahara, Fumiyoshi Yamashita, Mitsuru Hashida.
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 32(11) Issue: 11 Pages: 3604-3617
- DOI
  10.1007/s11095-015-1720-4
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001
[Journal Article] Artificial neural network analysis for predicting human percutaneous absorption taking account of vehicle properties2015
- Author(s)
  Tomomi Atobe, Masaaki Mori, Fumiyoshi Yamashita, Mitsuru Hashida, Hirokazu Kouzuki
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 2 Pages: 277-294
- DOI
  10.2131/jts.40.277
- NAID
  130004904033
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102
[Journal Article] 薬物代謝酵素の誘導に基づく薬物間相互作用の予測2014
- Author(s)
  吉田秀哉、山下富義
- Journal Title
  
  Drug Delivery System
  
  Volume: 29 Pages: 417-425
- NAID
  130004874241
- Data Source
  KAKENHI-PLANNED-23136102
[Journal Article] Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex <i>via</i> Activation of Unfolded Protein Response2014
- Author(s)
  K. Matsumura, C. Sakai, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 4 Pages: 648-653
- DOI
  10.1248/bpb.b13-00930
- NAID
  130003390969
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds2014
- Author(s)
  Peter Buchwald, Fumiyoshi Yamashita
- Journal Title
  
  Molecular Informatics
  
  Volume: 33 Issue: 1 Pages: 8-14
- DOI
  10.1002/minf.201300132
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-25670073
[Journal Article] Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling2014
- Author(s)
  Hasan Babazada, Fumiyoshi Yamashita, Shinya Yanamoto, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 194 Pages: 332-340
- DOI
  10.1016/j.jconrel.2014.09.011
- NAID
  120005512273
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102
[Journal Article] Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase.2014
- Author(s)
  Hideyuki Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita and Mitsuru Hashida
- Journal Title
  
  Journal of Biotechnology
  
  Volume: 186 Pages: 139-147
- DOI
  10.1016/j.jbiotec.2014.07.012
- NAID
  120005466731
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670259, KAKENHI-PROJECT-25702028
[Journal Article] Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling2014
- Author(s)
  Hasan Babazada, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 194 Pages: 295-300
- DOI
  10.1016/j.jconrel.2014.09.015
- NAID
  120005512274
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102
[Journal Article] Tumour-associated macrophages targeted transfection with NF-kappaB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice2014
- Author(s)
  Y. Kono, S. Kawakami, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  J. Drug Targeting
  
  Volume: (in press) Issue: 5 Pages: 439-449
- DOI
  10.3109/1061186x.2014.880443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072, KAKENHI-PUBLICLY-25114705
[Journal Article] <i>In Vitro</i> Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages2014
- Author(s)
  Y. Kono, S. Kawakami, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 1 Pages: 137-144
- DOI
  10.1248/bpb.b13-00659
- NAID
  130003382116
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072, KAKENHI-PROJECT-23689003
[Journal Article] Automated extraction of information on chemical-P-glycoprotein interactions from the literature2013
- Author(s)
  Shuya Yoshida, Fumiyoshi Yamashita, Atsushi Ose, Kazuya Maeda, Yuichi Sugiyama, Mitsuru Hashida
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 53 Issue: 10 Pages: 2506-2510
- DOI
  10.1021/ci4003188
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102
[Journal Article] Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data2013
- Author(s)
  Fumiyoshi Yamashita, Yukako Sasa, Shuya Yoshida, Akihiro Hisaka, Yoshiyuki Asai, Hiroaki Kitano, Mitsuru Hashida, Hiroshi Suzuki
- Journal Title
  
  PLoS One
  
  Volume: 8(9) Issue: 9 Pages: 1-11
- DOI
  10.1371/journal.pone.0070330
- NAID
  120005343920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136002, KAKENHI-PLANNED-22136003, KAKENHI-PLANNED-22136015, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-25730180
[Journal Article] Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice2013
- Author(s)
  M. Ikemura, M. Nishikawa, K. Kusamori, M. Fukuoka, F. Yamashita, M. Hashida
- Journal Title
  
  J. Controlled Release
  
  Volume: 170(2) Issue: 2 Pages: 191-197
- DOI
  10.1016/j.jconrel.2013.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] The Role of Inter-segmental Differences in P-glycoprotein Expression and Activity along the Rat Small Intestine in Causing the Double-peak Phenomenon of Substrate Plasma Concentration2013
- Author(s)
  Sho Wada, Takashi Kano,Suzune Mita, Yoko Idota, Kaori Morimoto, Fumiyoshi Yamashita, Takuo Ogihara
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Issue: 2 Pages: 98-103
- DOI
  10.2133/dmpk.DMPK-12-RG-005
- NAID
  130004933523
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667, KAKENHI-PLANNED-23136102
[Journal Article] Enhancement of gene expression by transcriptional activation using doxorubicin-loaded liposome/pDNA complexes2012
- Author(s)
  K. Un, Y. Kono, F. Yamashita, S. Kawakami, M.Hashida
- Journal Title
  
  Pharmazie
  
  Volume: 67(5) Pages: 400-405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240072
[Journal Article] Efficient suppression of murine ICAM-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation2012
- Author(s)
  Keita Un, Shigeru Kawakami, Mitsuru Yoshida, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Hepatology
  
  Volume: (in press) Issue: 1 Pages: 259-269
- DOI
  10.1002/hep.25607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J01875, KAKENHI-PUBLICLY-23114506, KAKENHI-PROJECT-23240072, KAKENHI-PROJECT-23500567, KAKENHI-PROJECT-23689003
[Journal Article] Structure-Activity Relationship Modeling for Predicting Interactions with Pregnane X Receptor by Recursive Partitioning2012
- Author(s)
  Shuya Yoshida, Fumiyoshi Yamashita, Takayuki Itoh, Mitsuru Hashida
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 5 Pages: 506-512
- DOI
  10.2133/dmpk.DMPK-11-RG-159
- NAID
  130004463279
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390008, KAKENHI-PLANNED-23136102
[Journal Article] The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice2012
- Author(s)
  Shuwen Zhou・Shigeru Kawakami・Yuriko Higuchi・Fumiyoshi Yamashita・Mitsuru Hashida
- Journal Title
  
  Clinical and Experimental metastasis
  
  Volume: 29 Issue: 1 Pages: 63-70
- DOI
  10.1007/s10585-011-9429-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J02743, KAKENHI-PROJECT-23240072
[Journal Article] Automated information extraction and structure-activity relationship analysys of cytochrome P450 substrates2011
- Author(s)
  Fumiyoshi Yamashita, Chunlai Feng, Shuya Yoshida, Takayuki Itoh and Mitsuru Hashida
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 51 Issue: 2 Pages: 378-385
- DOI
  10.1021/ci100334z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390008
[Journal Article] Randomized trial of angiotensin II-receptor blocker vs.dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study)2011
- Author(s)
  Takeshi Yamashita, Hiroshi Inoue, Ken Okumura, Itsuo Kodama, Yoshifusa Aizawa, Hirotsugu Atarashi, Tohru Ohe, Hiroshi Ohtsu, Takao Kato, Shiro Kamakura, Koichiro Kumagai, Yoshihisa Kurachi, Yukihiro Koretsune, Tetsunori Saikawa, Masayuki Sakurai, Toshiaki Sato, Kaoru Sugi, Haruaki Nakaya, Makoto Hirai, Atsushi Hirayama, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki, Eiichi Watanabe, Satoshi Ogawa, on behalf of the J-RHYTHM II Investigators
- Journal Title
  
  Europace
  
  Volume: 13(4) Issue: 4 Pages: 473-479
- DOI
  10.1093/europace/euq439
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136002, KAKENHI-PROJECT-23390053
[Journal Article] Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice.2010
- Author(s)
  S. Zhou, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Cancer Letters 287(1)
  
  Pages: 75-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase.2009
- Author(s)
  K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 137(2)
  
  Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Immunostimulatory Characteristics Induced by LinearPolyethyleneimine/plasmid DNA Complexes in Cultured Macrophages2009
- Author(s)
  Yasunori Saito, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Human Gene Therapy 20(2)
  
  Pages: 137-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] A novel multi-dimensional visualization technique for understanding the design parameters of drug formulations2009
- Author(s)
  Fumiyoshi Yamashita, Takayuki Itoh, Shuya Yoshida, Mohammad K. Haidar and Mitsuru Hashida
- Journal Title
  
  Computers & Chemical Engineering
  
  Volume: 34 Pages: 1306-1311
- NAID
  120002511244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390008
[Journal Article] Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.2009
- Author(s)
  T. Okuda, S. Kawakami, Y. Higuchi, Y. Oka, T. Satoh, M. Yokoyama, F. Yamashita, M. Hashida
- Journal Title
  
  International Journal of Pharmaceutics 373(1-2)
  
  Pages: 100-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] DDS機能設計と開発における先端解析技術インシリコ薬物動態予測2009
- Author(s)
  山下富義
- Journal Title
  
  Pharm Tech Japan
  
  Volume: 25(13) Pages: 90-93
- Data Source
  KAKENHI-PROJECT-21390008
[Journal Article] Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism2008
- Author(s)
  Fumiyoshi Yamashita, et. al.
- Journal Title
  
  Journal of Chemical Information and Modeling 48(2)
  
  Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Insertion of nuclear factor-κB binding sequence into plasmid DNA for increased transgene expression in colon carcinomacells2008
- Author(s)
  Oranuch Thanaketpaisarn, Makiya Nishikawa, Takayuki Okabe, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Biotechnology 133(1)
  
  Pages: 36-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Novel hierarchical classification and visualization method for multi-objective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism2008
- Author(s)
  Fumiyoshi Yamashita, et. al.
- Journal Title
  
  Journal of Chemical Information and Modeling 48(2)
  
  Pages: 364-369
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] SOD derivatives prevent metastatic tumor gtowth aggravated by tumor removal.2008
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, M. Ikemura, F. Yamashita, M. Hashida
- Journal Title
  
  Clinical & Experimental Metastasis 25(5)
  
  Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Novel hierarchical classification and visualization method for multi-objective optimization of drug properties : . application to structure-activity relationship analysis of cytochrome P450 metabolism2008
- Author(s)
  Yamashita, F., Hara, H., Itoh, T., Hashida, M
- Journal Title
  
  J. Chemical Information and Modeling 48(2)
  
  Pages: 364-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.2008
- Author(s)
  T. Okuda, S. Kawakami, M. Yokoyama, T. Yamamoto, F. Yamashita, M. Hashida
- Journal Title
  
  International Journal of Pharmaceutics 357
  
  Pages: 318-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Hydrogen perpxide-mediated nuclear KappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.2008
- Author(s)
  Y. Kobayashi, M. Nishikawa, K. Hyoudou, F. Yamashita, M. Hashida
- Journal Title
  
  Cancer Science 99(8)
  
  Pages: 1546-1552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, M. Ikemura, Y. Kobayashi, A. Mendelsohn, N. Miyazaki, Y. Tabata, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 122(2)
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Automated extraction of information from the literature on chemical-CYP3A4 interactions2007
- Author(s)
  Feng, C., Yamashita, F., Hashida, M
- Journal Title
  
  J. Chemical Information and Modeling 47(6)
  
  Pages: 2449-2455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, S. Mukai, M. Ikemura, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 119
  
  Pages: 121-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] The potential role of fucosylated cationic liposome/NFkB decoy complexesin the treatment of cytokine-related liver disease2007
- Author(s)
  Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Biomaterials 28(3)
  
  Pages: 532-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Analysis of in vivo NF-kappaB activation during liver inflammation in mice: prevention by catalase delivery.2007
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Molecular Pharmacology 71(2)
  
  Pages: 446-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Efficient protection by cationizedcatalase against H2O2 injury in primary cultured alveolar epithelial cells2007
- Author(s)
  Takayuki Nemoto, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 121(1-2)
  
  Pages: 74-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity.2007
- Author(s)
  S. Ma, M. Nishikawa, K. Hyoudou, R. Takahashi, M. Ikemura, Y. Kobayashi, F. Yamashita, M. Hashida
- Journal Title
  
  Kidney International 72(12)
  
  Pages: 1474-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.2006
- Author(s)
  T. Okuda, S. Kawakami, T. Maeie, T. Niidome, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 114(1)
  
  Pages: 69-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipidconntaining galactosylated liposomes for hepatocellular carcinoma-selec tive targeting2006
- Author(s)
  Takeshi Terada, Mieko Iwai, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 111(3)
  
  Pages: 333-342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Visualization of large-scale aqueous solubility data using a novel hierarchical data visualization technique2006
- Author(s)
  Fumiyoshi Yamashita, Takayuki Itoh, Hideto Hara, Mitsuru Hashida
- Journal Title
  
  Journal of Chemical Information and Modeling 46(3)
  
  Pages: 1054-1059
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Quantitative structure/activity relationship modelling of pharmacokinetic properties using genetic algorithm-combined partial least squares method2006
- Author(s)
  Yamashita, F., Fujiwara, S., Wanchana, S., Hashida, M
- Journal Title
  
  J. Drug Targeting 14(7)
  
  Pages: 496-504
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice.2006
- Author(s)
  T. Okuda, S. Kawakami, N. Akimoto, T. Niidome, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 116(3)
  
  Pages: 330-336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase.2006
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Kuramoto, F. Yamashita, M. Hashida
- Journal Title
  
  Clinical & Experimental Metastasis 23(5-6)
  
  Pages: 269-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Quantitative structure/activity relationship modelling of pharmacokinetic properties using genetic algorithm-combined partial least squares method2006
- Author(s)
  Fumiyoshi Yamashita, Shin-ichi Fujiwara, Suchada Wanchana, Mitsuru Hashida
- Journal Title
  
  Journal of Drug Targeting 14(7)
  
  Pages: 496-504
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Visualization of large-scale aqueous solubility data using a novel hierarchical data visualization technique2006
- Author(s)
  Fumiyoshi Yamashita, et. al.
- Journal Title
  
  Journal of Chemical Information and Modeling 46(3)
  
  Pages: 1054-1059
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Analysis of the molecular interaction of glycosylated prpteins with rabbit liver asialoglycoprotein receptors using surface plasmon resonance spectroscopy2006
- Author(s)
  Takeshi Terada, Makiya Nishikawa, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis 41
  
  Pages: 966-972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Inhibition of pulmonary metastasis by all-trans retinoic acid incorporated in cationic liposomes in mice.2006
- Author(s)
  S. Suzuki, S. Kawakami, N. Chansri, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 116(1)
  
  Pages: 58-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Visualization of large-scale aqueous solubility data using a novel hierarchical data visualization technique2006
- Author(s)
  Yamashita, F., Itoh, T., Hara, H., Hashida, M
- Journal Title
  
  J. Chemical Information and Modeling 46(3)
  
  Pages: 1054-1059
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] Improved anti-oxidant activity of superoxide dismutase by direct chemical modification2006
- Author(s)
  Ishimoto N, Nemoto T, Nagayoshi K, Yamashita F, Hashida M
- Journal Title
  
  J.Control.Release 111(1-2)
  
  Pages: 204-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Quantitative structure/activity relationship modelling of pharmacokinetic properties using genetic algorithm-combined partial least squares method2006
- Author(s)
  Fumiyoshi Yamashita, et. al.
- Journal Title
  
  Journal of Drug Targeting 14(7)
  
  Pages: 496-504
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590140
[Journal Article] PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.2006
- Author(s)
  K. Hyoudou, M. Nishikawa, Y. Kobayashi, Y. Umeyama, F. Yamashita, M. Hashida
- Journal Title
  
  Free Radical Biology & Medicine 41(9)
  
  Pages: 1449-1458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Inhibition of peritoneal dissemination of tumor cells bysingle dosing of phosphodiester CpGoligonucleotide/cationic liposome complex2006
- Author(s)
  Yukari Kuramoto, Makiya Nishikawa, Kenji Hyoudou, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Controlled Release 115(2)
  
  Pages: 226-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid conntaining galactosylated liposomes for hepatocellular carcinoma-selective targeting.2006
- Author(s)
  T. Terada, M. Iwai, S. Kawakami, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Controlled Release 111(3)
  
  Pages: 333-342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Liver targeting of catalase by cationization for prevention of acute liver failure in mice2006
- Author(s)
  Ma SF, Nishikawa M, Katsumi H, Yamashita F, Hashida M.
- Journal Title
  
  J.Control.Release 110(2)
  
  Pages: 273-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice2006
- Author(s)
  Shigeru Kawakami, Yoshitaka Ito, Pensri Charoensit, Fumiyoshi Yamashita,Mitsuru Hashida
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 317(3)
  
  Pages: 1382-1390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209006
[Journal Article] Tissue-specific characteristics of in vivo electric gene transfer by tissue and intravenous injection of plasmid DNA.2005
- Author(s)
  O. Thanaketpaisarn, M. Nishikawa, F. Yamashita, M. Hashida
- Journal Title
  
  Pharmaceutical Research 22(6)
  
  Pages: 883-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex.2005
- Author(s)
  S. Fumoto, S. Kawakami, K. Shigeta, Y. Higuchi, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 315(2)
  
  Pages: 484-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation2005
- Author(s)
  Sakai M, Nishikawa M, Thanaketpaisarn O, Yamashita F, Hashida M.
- Journal Title
  
  Gene Ther. 12(7)
  
  Pages: 607-616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-Nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo2005
- Author(s)
  Katsumi H, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 314(3)
  
  Pages: 1117-1124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration.2005
- Author(s)
  S. Kawakami, P. Opanasopit, M. Yokoyama, N. Chansri, T. Yamamoto, T. Okano, F. Yamashita, M. Hashida
- Journal Title
  
  Journal of Pharmaceutical Sciences 94(2)
  
  Pages: 2606-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Cationic charge-dependent hepatic delivery of amidated serum albumin2005
- Author(s)
  Ma SF, Nishikawa M, Katsumi H, Yamashita F, Hashida M.
- Journal Title
  
  J.Control.Release 102(3)
  
  Pages: 583-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Uptake characteristics of galactosylated emulsion by HepG2 hepatoma cells2005
- Author(s)
  Managit C, Kawakami S, Yamashita F, Hashida M.
- Journal Title
  
  Int.J.Pharm. 301(1-2)
  
  Pages: 255-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation.2005
- Author(s)
  M. Sakai, M. Nishikawa, O. Thanaketpaisarn, F. Yamashita, M. Hashida
- Journal Title
  
  Gene Therapy 12(7)
  
  Pages: 607-616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016035
[Journal Article] Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation2004
- Author(s)
  Fumoto S, Kawakami S, Ito Y, Shigeta K, Yamashita F, Hashida M.
- Journal Title
  
  Mol.Ther. 10(4)
  
  Pages: 719-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Effect of polycyclic aromatic hydrocarbons on generation and efflux of glutathione conjugates in primary cultured alveolar epithelial cells2004
- Author(s)
  Keiko Nagayoshi, Takayuki Nemoto, Shunpei Yokoyama, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 19(6)
  
  Pages: 407-412
- NAID
  10014314905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] In silico approaches for predicting ADME properties of drugs2004
- Author(s)
  Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 19(5)
  
  Pages: 327-338
- NAID
  10014314476
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin : delivery of nitric oxide in vivo2004
- Author(s)
  Katsumi H, Nishikawa M, Ma SF, Yamashita F, Hashida M.
- Journal Title
  
  J.Pharm.Sci. 93(9)
  
  Pages: 2343-2352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] In silico approaches for predicting ADME properties of drugs2004
- Author(s)
  Fumiyoshi Yamashita et al.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 19(5)
  
  Pages: 327-338
- NAID
  10014314476
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice2004
- Author(s)
  Hattori Y, Kawakami S, Suzuki S, Yamashita F, Hashida M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 317(4)
  
  Pages: 992-999
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Two-and three-dimensional QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells2004
- Author(s)
  Suchada Wanchana, Fumiyoshi Yamashita, Hideto Hara, Shin-Ichi Fujiwara, Miki Akamatsu, Mitsuru Hashida
- Journal Title
  
  Journal of Pharmaceutical Sciences 93(12)
  
  Pages: 3057-3065
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] QSAR analysis of interstudy variable skin permeability based on the "latent membrane permeability" concept2003
- Author(s)
  Shin-ichi Fujiwara, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Journal of Pharmaceutical Sciences 92(10)
  
  Pages: 1939-1946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] Glycosylated cationic liposomes for carbohydrate receptor-mediated gene transfer2003
- Author(s)
  Nishikawa M, Kawakami S, Yamashita F, Hashida M.
- Journal Title
  
  Methods Enzymol. 373
  
  Pages: 384-399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver2003
- Author(s)
  Morimoto K, Nishikawa M, Kawakami S, Nakano T, Hattori Y, Fumoto S, Yamashita F, Hashida M.
- Journal Title
  
  Mol.Ther. 7(2)
  
  Pages: 254-261
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Analysis of hepatic disposition of native and galactosylated polyethylenimine complexed with plasmid DNA in perfused rat liver2003
- Author(s)
  Fumoto S, Kawakami S, Ishizuka M, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  Drug Metab.Pharmacokinet. 18(4)
  
  Pages: 230-237
- NAID
  10012458871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I : poly C in a murine lung metastasis model2003
- Author(s)
  Sakurai F, Terada T, Maruyama M, Watanabe Y, Yamashita F, Takakura Y, Hashida M.
- Journal Title
  
  Cancer Gene Ther. 10(9)
  
  Pages: 661-668
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver2003
- Author(s)
  Fumoto S, Nakadori F, Kawakami S, Nishikawa M, Yamashita F, Hashida M.
- Journal Title
  
  Pharm.Res. 20(9)
  
  Pages: 1452-1459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Journal Article] QSAR analysis of the inhibition of recombinant CYP 3A4 activity by structurally diverse compounds using a genetic algorithm-combined partial least squares method2003
- Author(s)
  Suchada Wanchana, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  Pharmaceutical Research 20(9)
  
  Pages: 1401-1408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Journal Article] Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study2003
- Author(s)
  Nishikawa M, Nakano T, Okabe T, Hamaguchi N, Yamasaki Y, Takakura Y, Yamashita F, Hashida M.
- Journal Title
  
  Bioconjug.Chem. 14(5)
  
  Pages: 955-961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209006
[Patent] 化合物群表示装置,化合物群表示方法,プログラム,及びコンピュータ読み取り可能な記録媒体2005
- Inventor(s)
  山下富義, 伊藤貴之
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2005-137690
- Filing Date
  2005-05-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590129
[Presentation] マイクロ流体デバイスにおけるCaco-2細胞層を介した薬物輸送に対する流れ刺激の影響2023
- Author(s)
  江口由佳、佐々木優子、津田真弘、角　拓己、宗可奈子、樋口ゆり子、山下富義
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-21K06642
[Presentation] 粘液および腸内細菌を導入したgut-on-a-chipの開発2023
- Author(s)
  角　拓己、津田真弘、江口由佳、宗可奈子、樋口ゆり子、山下富義
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-21K06642
[Presentation] クリック反応を利用したタンパクの細胞膜表面への部位特異的な修飾2022
- Author(s)
  平田剛、國井朋佳、横田美咲、樋口ゆり子、山下富義
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H03516
[Presentation] Erfluoropolyether elastomers as a material for microfluidic devices intended for drug metabolism studies（低吸収フッ素エラストマーデバイスの開発と薬物動態評価）2022
- Author(s)
  Mengyang Wang, Masahiro Tsuda, Kanako So, Yuriko Higuchi, Fumiyoshi Yamashita
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K06642
[Presentation] 糖鎖リガンドsLeX mimicと小胞体局在シグナルペプチドKDELを利用した小胞体へのタンパク質デリバリー2021
- Author(s)
  内田結、森川知彦、樋口ゆり子、山下富義
- Organizer
  第30回日本バイオイメージング学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] Targeted delivery of proteins and nucleic acids via carbohydrate binding receptors2021
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  Joint Symposium on Frontiers of Pharmaceutical Science and International Pharmaceutical Education
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] Polydimethylsiloxane製liver-on-a-chipを用いた薬物代謝・毒性試験2021
- Author(s)
  出口清香、津田真弘、小杉香織、水口裕之、山下富義、鳥澤勇介、高山和雄
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K06642
[Presentation] Development and evaluation of perfluoropolyether elastomer-based microfluidic devices for drug metabolism studies.2021
- Author(s)
  Mengyang Wang, Hirotaka Tatsuoka, Masahiro Tsuda, Kanako So, Yuriko Higuchi, Fumiyoshi Yamashita
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K06642
[Presentation] Targeted delivery of drugs, genes, and cells by using specialized ligand-receptor recognition systems2020
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  International Conference and Exhibition on Pharmaceutical Sciences and Technology 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] sLeX mimic修飾抗 MDM2 scFvによるHUVECの血管新生阻害2020
- Author(s)
  森川知彦、采女紗也、河村奈緒子、安藤弘宗、樋口ゆり子、山下富義
- Organizer
  日本薬剤学会　第35年会
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] 抗HIV薬ドルテグラビルの吸収動態に対する薬物排出トランスポーターBCRPの寄与2020
- Author(s)
  宇野瑞樹, 神谷武志, 津田真弘, 山下富義
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-18K06747
[Presentation] 薬物排出トランスポーターBCRP を介したインテグラーゼ阻害薬の輸送評価2019
- Author(s)
  宇野瑞樹、神谷武志、津田真弘、山下富義
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06747
[Presentation] Bio-distribution characteristics of liposomes bearing structurally simplified sialyl Lewis X2018
- Author(s)
  Yuuki Yamane,Chanikarn Chantarasrivong, Ryosaku Ohta, Yuriko Higuchi, Mitsuru Hashida, Fumiyoshi Yamashita
- Organizer
  日本薬物動態学会第33回年会/MDO国際合同学会
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] 構造単純化シアリルルイス X 修飾リポソームの創製と物性・体内動態評価2018
- Author(s)
  山根悠暉、Chantarasrivong Chanikarn、太田亮作、樋口ゆり子、橋田充、山下富義
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] ヒアルロン酸修飾高分子ナノカプセルによる水溶性薬物のがん細胞内送達2018
- Author(s)
  麻生寛人、樋口ゆり子、津田真弘、山下富義
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K06747
[Presentation] Bio-distribution characteristics of liposomes bearing structurally simplified sialyl Lewis X2018
- Author(s)
  Yuuki Yamane,Chanikarn Chantarasrivong, Ryosaku Ohta, Yuriko Higuchi, Mitsuru Hashida, Fumiyoshi Yamashita
- Organizer
  日本薬物動態学会第33回年会/MDO国際合同学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] 薬学系からみた最近のDDSのトピックと将来展望2018
- Author(s)
  山下富義
- Organizer
  第34回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] Application of machine learning techniques to pharmacokinetic analysis2018
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  13th France-Japan DDS Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] Data mining technologies in accelerating ADME screening2018
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  The 5th Asian Symposium on Pharmaceutical Science and Technology & the 5th Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03531
[Presentation] ユビキチン－プロテアソーム系によるリプレッサー分解を利用した新規遺伝子発現制御システムの構築2017
- Author(s)
  〇高見理沙、樋口ゆり子、佐々木明彦、山下富義、橋田　充
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] In silico pharmacokinetics: from QSAR to system modeling2017
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History
- Place of Presentation
  京都リサーチパーク（京都府）
- Year and Date
  2017-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K08071
[Presentation] Anti-inflammatory effect of self-assembling glycol-split glycosaminoglycan-stearylamine conjugates in lipopolysaccharide-stimulated macrophages2017
- Author(s)
  Shinya Yanamoto, Hasan Babazada, Shinya Sakai, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History
- Place of Presentation
  京都リサーチパーク（京都府）
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-15K08071
[Presentation] 多階層生体機能モデリング・シミュレーション環境を利用した薬物間相互作用の動的シミュレーション2017
- Author(s)
  山下富義
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  東北大学川内北キャンパス（宮城県）
- Year and Date
  2017-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K08071
[Presentation] 多階層生体機能モデリング・シミュレーション環境を利用した薬物間相互作用の動的シミュレーション2017
- Author(s)
  山下富義
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  東北大学川内北キャンパス（宮城）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] Functional Characterization of novel Sialyl Lewix X mimic coated-liposomes targeting to E-selectin2016
- Author(s)
  Chanikarn Chantarasrivong, Akiharu Ueki, Hiromune Ando, Shinya Nakamura, Isao Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita, Makoto Kiso, Mitsuru Hashida
- Organizer
  3ｒｄ International Conference on Biomaterials Science in Tokyo
- Place of Presentation
  東京大学本郷キャンパス（東京）
- Year and Date
  2016-11-28
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] 不整脈原性RyR2変異のCa2+遊離特性　- カテコラミン誘発性多型性心室頻拍（CPVT）変異と特発性心室細動（I-VF）変異の比較‐.2016
- Author(s)
  呉林なごみ, 村山尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井隆.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Development and evaluation of sialyl lewis X mimic-coated liposomes2016
- Author(s)
  Chanikarn Chantarasrivong, Akiharu Ueki, Hiromune Ando, Shinya Nakamura, Isao Nakanishi, Yuriko Higuchi, Fumiyoshi Yamashita, Makoto Kiso, Mitsuru Hashida
- Organizer
  The 1st Workshop Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  京都教育文化センター（京都）
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01861
[Presentation] 薬物間相互作用のin silico予測2016
- Author(s)
  山下富義
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子市文化ホール（鳥取県）
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-15K08071
[Presentation] In vitro-in vivo補外予測によりin vivo動態試験のサンプリングコストを低減できるか？2015
- Author(s)
  山下富義、酒井千賀、橋田充
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（神戸市）
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 薬物動態学的相互作用の予測を目指した多階層生体モデリング2015
- Author(s)
  山下富義
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-03-19
- Invited
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Naチャネルの変異に伴う心室筋細胞活動電位の変化のシミュレーション.2015
- Author(s)
  稲田慎, 吉田秀哉, 相庭武司, 山下富義, 中沢一雄.
- Organizer
  第３５回医療情報学連合大会
- Place of Presentation
  沖縄コンベンションセンター（宜野湾市）
- Year and Date
  2015-11-03
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 2 型リアノジン受容体の不整脈原性変異はCICR 活性と細胞内Ca2+動態にどのような影響を及ぼすか?2015
- Author(s)
  呉林なごみ、村山尚、太田亮作、山下富義、鈴木純二、金丸和典、飯野正光、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] コンピューターサイエンスがもたらす薬剤学研究のイノベーション2015
- Author(s)
  山下富義
- Organizer
  第21回創剤フォーラム若手研究会
- Place of Presentation
  東京大学薬学部（東京都文京区）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K08071
[Presentation] 薬物動態学的相互作用の予測を目指した多階層生体モデリング2015
- Author(s)
  山下富義
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] コンピューターサイエンスがもたらす薬剤学研究のイノベーション.2015
- Author(s)
  山下富義.
- Organizer
  第21回創剤フォーラム若手研究会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-11-28
- Invited
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 2 型リアノジン受容体の不整脈原性変異はCICR 活性と細胞内Ca2+動態にどのような影響を及ぼすか?2015
- Author(s)
  呉林なごみ、村山尚、太田亮作、山下富義、鈴木純二、金丸和典、飯野正光、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] In vitro-in vivo補外予測によりin vivo動態試験のサンプリングコストを低減できるか？2015
- Author(s)
  山下富義、酒井千賀、橋田　充
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸サンボーホール（神戸）
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Modeling and prediction of cytochrome P450 induction-mediated drug-drug interaction2014
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  11th France-Japan DDS Symposium
- Place of Presentation
  淡路夢舞台国際会議場（淡路市）
- Year and Date
  2014-10-06
- Invited
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Computer-aided full-automatic construction of covariate models in population pharmacokinetic analysis2014
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
- Organizer
  Joint Scientific Meeting: 29th JSSX Meeting and 19th North American ISSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square (San Francisco, CA, USA)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 自己組織化ヘパリン誘導体の抗炎症作用と構造活性相関2014
- Author(s)
  山下富義、Hasan Babazada、酒井千賀、橋田充
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザ（熊本市）
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 自己組織化ヘパリン誘導体の抗炎症作用と構造活性相関2014
- Author(s)
  山下富義、Hasan Babazada、酒井千賀、橋田充
- Organizer
  第42回構造活性相関シンポジウム
- Place of Presentation
  くまもと森都心プラザ（熊本）
- Year and Date
  2014-11-14
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Modeling and prediction of cytochrome P450 induction-mediated drug-drug interaction2014
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  11th France-Japan DDS Symposium
- Place of Presentation
  淡路夢舞台国際会議場（淡路）
- Year and Date
  2014-10-06
- Invited
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Computer-aided full-automatic construction of covariate models in population pharmacokinetic analysis2014
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
- Organizer
  Joint Scientific Meeting: 29th JSSX Meeting and 19th North American ISSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square (San Francisco)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-25670073
[Presentation] Computer-aided full-automatic construction of covariate models in population pharmacokinetic analysis2014
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
- Organizer
  Joint Scientific Meeting: 29th JSSX Meeting and 19th North American ISSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square (San Francisco)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] スフィンゴシン結合両親媒性ヘパリンによるナノ粒子の調整と物性評価2013
- Author(s)
  福岡美帆、Hasan Babazada、山下富義、橋田　充
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] スフィンゴシン結合両親媒性ヘパリンによるナノ粒子の調整と物性評価2013
- Author(s)
  福岡美帆、 Hasan Babazada、山下富義、橋田充
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] Utilization of machine learning techniques to pursue automatic PPK modeling2013
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  2013 PAGJA-PAGK Joint Annual Meeting
- Place of Presentation
  Grand Hilton Seoul (Seoul)
- Invited
- Data Source
  KAKENHI-PROJECT-25670073
[Presentation] マンノース修飾バブルリポソームを用いたNF-kappaB 活性制御による腫瘍関連マクロファージのphenotype 変化2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、鈴木亮、丸山一雄、山下富義、橋田充
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち(愛知県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] マンノース修飾バブルリポソームを用いたNF-kappaB活性制御による腫瘍関連マクロファージのphenotype変化2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、鈴木亮、丸山一雄、山下富義、橋田充
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] 情報科学的アプローチによる薬物動態の予測2013
- Author(s)
  山下富義
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学板橋キャンパス（東京）
- Invited
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Mechanisms of anti-inflammatory effect of heparin-sphingosine nanoparticles in activated macrophages in vitro2013
- Author(s)
  Hasan Babazada、福岡美帆、山下富義、橋田充
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] 多階層生体機能モデリング・シミュレーションプラットフォームを利用した酵素誘導型薬物間相互作用シミュレータの開発2013
- Author(s)
  山下富義、笹友香子、吉田秀哉、樋坂章博、浅井義之、北野宏明、橋田充、鈴木洋史
- Organizer
  第29回Population Pharmacokinetics研究会
- Place of Presentation
  慶應義塾大学日吉キャンパス協生館藤原洋記念ホール（神奈川）
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Impact and application of data mining in ADME researches2013
- Author(s)
  山下富義
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Invited
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] 遺伝的数式プログラミング法を用いたCYP3A4阻害活性に対する構造活性相関解析2013
- Author(s)
  吉田秀哉、藤田淳人、山下富義、橋田　充
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Visualization of IkappaBalpha dagradation in hela cells with IkappaBalpha fragments fused to mK022013
- Author(s)
  Nilufar Rahimova, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第28回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25670259
[Presentation] マンノース６リン酸受容体を標的としたがん細胞指向性新規糖修飾リポソームの開発2013
- Author(s)
  松田顕也、川上茂、安藤弘宗、樋口ゆり子、山下富義、木曽真、橋田充
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都テルサ（京都府）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Automated information extraction and structure-activity relationship analysis of cytochrome P450 substrates2013
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  9th Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  The Villas of Grand Cypress Orlando, Orlando
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] NF-kB decoyの腫瘍関連マクロファージ選択的DDSの開発：TAM phenotypeの再分化の誘導評価2013
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] 情報科学的アプローチによる薬物動態の予測2013
- Author(s)
  山下富義
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学（東京）
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Mechanisms of anti-inflammatory effect of heparin-sphingosine nanoparticles in activated macrophages in vitro2013
- Author(s)
  Hasan Babazada、福岡美帆、山下富義、橋田　充
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] Impact and application of data mining in ADME researches2013
- Author(s)
  山下富義
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 遺伝的数式プログラミング法を用いたCYP3A4阻害活性に対する構造活性相関解析2013
- Author(s)
  吉田秀哉、藤田淳人、山下富義、橋田　充
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-25670073
[Presentation] 多階層生体機能モデリング・シミュレーションプラットフォームを利用した酵素誘導型薬物間相互作用シミュレータの開発2013
- Author(s)
  山下富義、笹友香子、吉田秀哉、樋坂章博、浅井義之、北野宏明、橋田充、鈴木洋史
- Organizer
  第29回Population Pharmacokinetics研究会
- Place of Presentation
  慶応大学日吉キャンパス（横浜）
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Automated information extraction and structure-activity relationship analysis of cytochrome P450 substrates2013
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  9th Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  The Villas of Grand Cypress Orlando (Orlando)
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] Utilization of machine learning techniques to pursue automatic PPK modeling2013
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  2013 PAGJA-PAGK Joint Annual Meeting
- Place of Presentation
  Grand Hilton Seoul (Seoul, Korea)
- Data Source
  KAKENHI-ORGANIZER-22136001
[Presentation] 遺伝的数式プログラミング法を用いたCYP3A4阻害活性に対する構造活性相関解析2013
- Author(s)
  吉田秀哉、藤田淳人、山下富義、橋田　充
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] In Silico Pharmacokinetics : from QSAR to PK Modeling2012
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] In Silico Pharmacokinetics : from QSAR to PK Modeling2012
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] P-glycoprotein輸送基質に関する構造活性相関解析2012
- Author(s)
  吉田秀哉、山下富義、尾瀬淳、前田和也、杉山雄一、橋田充
- Organizer
  日本動物実験代替法学会第25回大会
- Place of Presentation
  慶應義塾大学薬学部（東京都）
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] NF-kB を標的とする抑制性オリゴ核酸による癌微小環境中のマクロファージの免疫再賦活化2012
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Place of Presentation
  仙台市民会館(宮城県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] GRP78 siRNAリポプレックスによるがん細胞アポトーシスの誘導と抗がん剤耐性の克服2012
- Author(s)
  松村一史、川上茂、山下富義、橋田充
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Chemoinformatic Modeling for Discriminating Pregnane X Receptor Activators2012
- Author(s)
  Shuya Yoshida, Fumiyoshi Yamashita
- Organizer
  1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics
- Place of Presentation
  東京大学(東京都)
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Pharmacokinetic Modeling Considering Dynamics of Induction of Drug Metabolizing Enzymes2012
- Author(s)
  Yukako Sasa, Fumiyoshi Yamashita
- Organizer
  1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics
- Place of Presentation
  東京大学(東京都)
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] ヘパリンナノパーティクルの物性及び免疫抑制効果の検討2012
- Author(s)
  Hasan Babazada、福岡美帆、山下富義、橋田充
- Organizer
  日本薬物動態学会第27 年会
- Place of Presentation
  タワーホール船堀(東京都)
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] 再帰分割法を用いた化合物／Pregnane X receptor間相互作用に関する構造活性相関解析2012
- Author(s)
  吉田秀哉、山下富義、橋田　充
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Immunosuppressive effect of heparin nanoparticles on activated macrophages in primary culture2012
- Author(s)
  Hasan Babazada, Miho Fukuoka, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第27回日本薬物動態学会年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-23659022
[Presentation] Chemoinformatic Modeling for Discriminating Pregnane X Receptor Activators2012
- Author(s)
  Shuya Yoshida, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  1st HD Physiology International Symposium : Integrative Multi-level Systems Biology for In silico Cardiology and Pharmacokinetics
- Place of Presentation
  東京大学(東京都)
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] NF-ｋBを標的とする抑制性オリゴ核酸による癌微小環境中のマクロファージの免疫再賦活化2012
- Author(s)
  河野裕允、川上茂、樋口ゆり子、山下富義、橋田充
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム２０１２
- Place of Presentation
  仙台市民会館（宮城県）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] Prediction of drug-drug interactions with rifampicin based on dynamics of induction of cytochrome P450 3A42012
- Author(s)
  Y. Sasa, F. Yamashita, M. Hashida
- Organizer
  第28回Population Pharmacokinetics研究会
- Place of Presentation
  臨床研究情報センター（兵庫県）
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] 遺伝的数式プログラミング法によるCYP3A4阻害活性予測モデルの構築2012
- Author(s)
  藤田淳人、山下富義、橋田　充
- Organizer
  日本動物実験代替法学会第25回大会
- Place of Presentation
  慶應義塾大学薬学部（東京都）
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Evalution of the inhibition of NF-κB activity by using decoy oligonucleotides on the immune response of macrophages cultured in various cancer cells conditioned medium2012
- Author(s)
  Yusuke Kono, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都大学薬学部（京都府）
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] In Silico Prediction of Pregnane X Receptor Activators by Classification Tree Model2011
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Evalustion of endosomal escape of lysine-histidine dendrons by live cell imaging2011
- Author(s)
  Yuriko Higuchi, Kai-ling Chang, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場(広島県)
- Data Source
  KAKENHI-PROJECT-23240072
[Presentation] In Silico Prediction of Pregnane X Receptor Activators by Classification Tree Model2011
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, and Mitsuru Hashida
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] 進化的アルゴリズムを利用した母集団薬物動態モデル構築の自動化2011
- Author(s)
  笹友香子、山下富義、橋田充
- Organizer
  第4回日本ファーマコメトリクス研究会
- Place of Presentation
  昭和大学(東京都)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PLANNED-23136102
[Presentation] Techniques for ADME Screening2011
- Author(s)
  Fumiyoshi Yamashita, Data Mining and Visualization
- Organizer
  Spring International Convention of The Pharmaceutical Society of Korea
- Place of Presentation
  Busan Exhibition and Convention Center(Busan)
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] In Silico Prediction of Pregnane X Receptor Activators by Classification Tree Model2011
- Author(s)
  Fumiyoshi Yamashita, Shuya Yoshida, Mitsuru Hashida
- Organizer
  The 8th AFMC International Medicinal Chemistry Symposiun
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] CpG DNA lipoplex経鼻投与による肺転移・腹膜播種抑制の機構解明2010
- Author(s)
  周舒文, 川上茂, 山下富義, 橋田充
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Data mining and visualization techniques for ADME screening2010
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  FIP Pharmaceutical Sciences 2010 World Congress in association with the AAPS Annual Meeting and Exposition
- Place of Presentation
  Ernest N.Morial Convention Center(New Orleans, USA)(招待講演)
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] CYP-化合物間相互作用情報のテキストマイニングと構造活性相関解析2010
- Author(s)
  吉田秀哉, 山下富義, 橋田充
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] Automated knowledge acquisition and structure-activity relationship analysis regarding cytochrome P450 metabolism2010
- Author(s)
  Fumiyoshi Yamashita, Chunlai Feng, Shuya Yoshida, Mitsuru Hashida
- Organizer
  18th European Symposium on Quantitative Structure-Activity Relationships
- Place of Presentation
  The Rodos Palace International Convention Centre(Rhodes)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] Techniques for ADME Screening2010
- Author(s)
  Fumiyoshi Yamashita, Data Mining and Visualization
- Organizer
  FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  The Ernest N. Morial Convention Center(New Orleans)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] 構造活性相関法に基づくin slico薬物動態予測2010
- Author(s)
  山下富義
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] CpGDNA lipoplexp経鼻投与による肺転移・腹膜播種抑制の機構解明2010
- Author(s)
  周舒文, 川上茂, 山下富義, 橋田充
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Automated knowledge acquisition and structure-activity relationship analysis regarding cytochrome P450 metabolism2010
- Author(s)
  Fumiyoshi Yamashita, Chunlai Feng, Shuya Yoshida, Mitsuru Hashida
- Organizer
  18th European Symposium on Quantitative Structure-Activity Relationships
- Place of Presentation
  Rhodes Palace Hotel(ギリシア)
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] コンピュータを利用した薬物動態評価・予測の方法論2009
- Author(s)
  山下富義
- Organizer
  第2回ファーマコメトリクス研究会
- Place of Presentation
  昭和大学上條講堂(東京都)
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-21390008
[Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009
- Author(s)
  増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル(東京)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] アミノ酸デンドリマーを用いたDNAアプタマーの生体内応用に向けたアプローチ:癌細胞指向型アプタマー/デンドリマー結合体の開発2009
- Author(s)
  増田真理恵、川上茂、Wijagkanalan Wassana、山下富義、橋田充
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京ドームホテル(東京都)
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Enhanced growth inhibition of metastatic lung tumor by intravenous injection of IL12-ATRA-lipoplexes in mice2009
- Author(s)
  Pensri Charoensit, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Inhalation of Dexamethasone Palmitate Encapsulated Mannosylated Liposomes Efficiently Ameliorates LPS-Induced Lung Inflammation in Rats2008
- Author(s)
  Wassana Wijagkanalan, Shigeru Kawakami, Mariko Kuroda, Hitoshi Sasaki, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Inhalation of Dexamethasone Palmitate Encapsulated Mannosylated Liposomes Efficiently Ameliorates LPS-Induced Lung Inflammation in Rats2008
- Author(s)
  Wassana wijagkanalan, Shigeru Kawakami, Mariko Kuroda, Hitoshi Sasaki, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リボソーム研究会議
- Place of Presentation
  横浜シンポジア
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Evaluation of proinflammatory cytokine production induced by siRNA/polyethylenimine complexes2008
- Author(s)
  Pensri Charoensit, 川上茂, 山下富義, 橋田充
- Organizer
  第24回日本DDS学会
- Place of Presentation
  六本木アカデミーヒルズ
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Evaluation of proinflammatory cytokine production inducedby siRNA/polyethylenimine complexes2008
- Author(s)
  Pensri Charoensit、川上茂、山下富義、橋田充
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-18209006
[Presentation] Intranasally Administered CpG DNA /Cationic Liposome Complexes Prevents Lung Metastases in Mice2008
- Author(s)
  Shuwen Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜シンポジア(神奈川)
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Intranasally Administered CpG DNA/Cationic Liposome Complexes Prevents Lun Metastases in Mice2008
- Author(s)
  Shuwen-Zhou, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  第11回国際リポソーム研究会議
- Place of Presentation
  横浜シンポジア
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-17016035
[Presentation] Text Mining and QSAR Analysis on Chemicals-Cytochrome P450s Interactions2007
- Author(s)
  Hideto Hara, Chunlai Feng, Takayuki Itoh, Fumiyoshi Yamashita, Mitsuru Hashida
- Organizer
  the 3rd Pharmaceutical Sciences World Congress(PSWC 2007)
- Place of Presentation
  Amsterdam
- Year and Date
  2007-04-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Informatics-based data acquisition and structure-activity relationship analysis of Cytochrome P450 interactions2007
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  6th Retrometabolism Based Drug Design and Targeting Conference
- Place of Presentation
  God, Hungary
- Year and Date
  2007-06-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] In silico knowledge acquisition and data minihg in the cyp-chemical interaction studies2007
- Author(s)
  Fumiyoshi, Yamashita
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai, Japan
- Year and Date
  2007-10-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Text Mining and QSAR Analysis on Chemicals-Cytochrome P450s Interactions2007
- Author(s)
  Hideto, Hara, Chunlai, Feng, Takayuki, Itoh, Fumiyoshi, Yamashita, Mitsuru, Hashida
- Organizer
  the 3rd Pharmaceutical Sciences World Congress (PSWC 2007)
- Place of Presentation
  Amsterdam
- Year and Date
  2007-04-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] In silico knowledge acquisition and data mining in the cyp-chemical interaction studies2007
- Author(s)
  Fumiyoshi Yamashita
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Computer-aided evaluation of drug absorbability and acceleration of drug discovery and development2006
- Author(s)
  Fumyioshi, Yamashita
- Organizer
  43th Yakuzaigaku Kondankai
- Place of Presentation
  Shizuoka
- Year and Date
  2006-06-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] コンピュータを利用した薬物吸収性評価と創薬の効率化2006
- Author(s)
  山下富義
- Organizer
  第43回薬剤学懇談会研究討論会
- Place of Presentation
  静岡
- Year and Date
  2006-06-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Hashida : Comprehensive structure-activity relationship analysis and information visualization of cytochrome P450 metabolism2006
- Author(s)
  Hideto, Hara, Fumiyoshi, Yamashita, Takayuki, Itoh, Mitsuru
- Organizer
  21th Annual Meeting of Japanese Society for the Study of Xenobiotics
- Place of Presentation
  Tokyo
- Year and Date
  2006-11-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] 化合物とチトクロームP450との相互作用に関する構造活性相関解析2006
- Author(s)
  馮春来、山下富義、橋田充
- Organizer
  第34回構造活性相関シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2006-11-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Acquisition of extended information regarding chemicals-CYPs interactions by natural language processing2006
- Author(s)
  Chunlai Feng、 Fumiyoshi Yamashita、 Mitsuru Hashida
- Organizer
  2006 Annual Meeting of CBI Society
- Place of Presentation
  Tokyo
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Structure-activity relationship of chemical-cytochrome P450 interactions2006
- Author(s)
  Chunlai, Feng, Fumiyoshi, Yamashita, Mitsuru, Hashida
- Organizer
  34th KouzoKasseiSokan Symposium
- Place of Presentation
  Niigata
- Year and Date
  2006-11-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] チトクロムP450代謝の包括的構造活性相関解析と情報可視化2006
- Author(s)
  原秀人、山下富義、伊藤貴之、橋田充
- Organizer
  第21回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2006-11-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140
[Presentation] Computer-Based Information Acquisition and Analysis of CYP3A4 Drug Interaction2006
- Author(s)
  Fumiyoshi Yamashita, Chunlai Feng, Mitsuru Hashida
- Organizer
  7th France-Japan DDS Symposium
- Place of Presentation
  Ohtsu
- Year and Date
  2006-09-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590140

1. HASHIDA Mitsuru (20135594)

# of Collaborated Projects: 11 results

# of Collaborated Products: 73 results
2. YURIKO Higuchi (40402797)

# of Collaborated Projects: 8 results

# of Collaborated Products: 23 results
3. KAWAKAMI Shigeru (20322307)

# of Collaborated Projects: 6 results

# of Collaborated Products: 43 results
4. NISHIKAWA Makiya (40273437)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
5. ITO Takayuki (80401595)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. AMANO Akira (60252491)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OKUNO Yasushi (20283666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HASHIDA Yasuhiko (30512462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
9. TAKAKURA Yoshinobu (30171432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Tsuda Masahiro (10726813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
11. FENG Chunlai (40456835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. KURACHI YOSHIHISA (30142011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. INOUE Ryuji (30232573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. KITANO Hiroaki (80500256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KINOSHITA Kengo (60332293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HARI Yoshiyuki (50347423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MAKITA Naomasa (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ISHIKAWA Yoshihiro (40305470)

# of Collaborated Projects: 1 results

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21. HONJO Haruo (70262912)

# of Collaborated Projects: 1 results

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22. NAKAZAWA Kazuo (50198058)

# of Collaborated Projects: 1 results

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23. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 1 results

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24. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects: 1 results

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25. NIIJIMA Satoshi (30456834)

# of Collaborated Projects: 1 results

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26. INOGUCHI Akihiro (70452456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. YANO Ikuko (50273446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAMAOKA Kiyoshi (50109013)

# of Collaborated Projects: 1 results

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29. 杉山直幸 (50545704)

# of Collaborated Projects: 1 results

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30. 宗可奈子 (50816684)

# of Collaborated Projects: 1 results

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31. 小西聡 (50288627)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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33. 浅井義之 (00415639)

# of Collaborated Projects: 1 results

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34. 喜多知子 (20362519)

# of Collaborated Projects: 1 results

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35. 佐藤篤靖 (30706677)

# of Collaborated Projects: 1 results

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36. 岸本曜 (80700517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 高山和雄 (10759509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamashita Fumiyoshi 山下 富義

YAMASHITA Fumiyoshi 山下 富義

山下 富義 ヤマシタ フミヨシ

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糖代謝疾患の時間発展評価を目指した仮想現実統合型生体チップモデルの開拓Principal Investigator

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Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motilityPrincipal Investigator

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Muti-step targeted drug delivery to endoplasmic reticulum via retrograde transport systemsPrincipal Investigator

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Mechanism of anti-inflammatory action of self-assembling heparion nanoparticlesPrincipal Investigator

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Full-automatic PopPK modeling utilizing an evolutionary algorithmPrincipal Investigator

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Integrated analysis of biological interaction of small molecules at the molecular level of living organismsPrincipal Investigator

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Yamashita Fumiyoshi 山下富義

YAMASHITA Fumiyoshi 山下富義

山下富義ヤマシタフミヨシ