Sakaguchi Shimon 坂口志文

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SAKAGUCHI Shimon 坂口志文

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Researcher Number	30280770
Other IDs
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Affiliation (Current)	2025: 大阪大学, 免疫学フロンティア研究センター, 特任教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) 2016 – 2020: 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) 2014 – 2016: 大阪大学, 免疫学フロンティア研究センター, 教授 2011 – 2012: 大阪大学, 免疫学フロンティア研究センター, 教授 1999 – 2010: 京都大学, 再生医科学研究所, 教授 … More 2006: 京都大学, 再生医学研究所, 教授 2000: 京都大学, 再生医学研究所, 教授 1998: 財団法人東京都老人総合研究所, 免疫病理部門, 研究室長 1996 – 1997: 東京都老人総合研究所, 免疫病理部門, 研究室長 1996: 東京都老人総合研究所, 部長 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Immunology / Biological Sciences / Immunology / Immunology / Experimental pathology Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 55030:Cardiovascular surgery-related / Biological Sciences … More / Endocrinology / Experimental pathology / General surgery / Immunology / Obstetrics and gynecology Less
Keywords	Principal Investigator 自己免疫病 / 制御性T細胞 / 免疫制御 / Foxp3 / T細胞 / Regulatory T cell / 免疫学 / 免疫自己寛容 / CTLA-4 / 自己免疫 … More / トランスジェニックマウス / T細胞分化 / ゲノム解析 / Protein / Dysfunction / Drug / Exhaustion / CD8 / Immunotherapy / Cancer / 発生・分化 / 発現制御 / シグナル伝達 / エピジェネティクス / 自己免疫疾患 / 自己免疫寛容 / Immunological self-tolerance / Genetic susceptibilit / Co-stimulatory molecule / Semaphoring / Dendritic cells / Autoimmune disease / GITR / 病理学 / 単クローン抗体 / CD25 / helios / Gpr83 / GITR-L / 移植免疫 / 腫瘍免疫 / 樹状細胞 / 遺伝的疾患感受性 / セマフォリン / 教刺激分子 / 自己抗原 / ZAP-70 / 関節リウマチ / 自己免疫性関節炎 / SKG / T細胞抗原レセプター / Ｔ細胞抗原レセプター / Ｔリンパ球 / エピゲノム / 制御性Ｔ細胞 / Tリンパ球 / FOXP3 / 疾患遺伝子 / 動物モデル / 関節炎 / 遺伝子異常 / 慢性関節リウマチ / 疾患モデル / T細胞性制御 / 免疫的自己寛容 … More Except Principal Investigator 制御性T細胞 / CBP / AIRE / APS-1 / APECED / 免疫寛容 / 腫瘍免疫 / Single cell analysis / B-cells / Mass Cytometry / 免疫拒絶反応 / 移植免疫 / 再生医療 / 心臓移植 / 心不全 / 免疫疾患 / Dendritic cells / Antigen presenting cells / Thymus / Autoimmune disease / 転写調節因子 / RelB / 免疫応答 / トランスジェニックマウス / SV40T抗原 / 樹状細胞 / 抗原提示細胞 / 胸腺 / 自己免疫疾患 / ANERGY / TUMOR IMMUNOLOGY / CD25^+ T CELLS / アナージー / アナージ / CD25^+T細胞 / Transcriptional factor / Biosensor / Crystallin gene / Polycomb genes / Transgenics / B cell / Immunological tolerance / T cell / 転写因子 / 有機リン系農薬センサー / 水晶体特異的遺伝子発現 / ポリコ-ム遺伝子 / 発生工学 / B細胞 / T細胞 / 皮下移植 / 移植 / 血糖値 / 糖尿病 / 膵島 / ランゲルハンス氏島 / 免疫制御 / Antibody responses / T Follicular helper / Antibody response / Vaccination / T follicular helper / Regulatory T-cells / PD-L1 / 婦人科悪性腫瘍 / 免疫回避機構 / NK細胞 / BMP / 免疫逃避機構 / PD-1 / 婦人科腫瘍 Less

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseasesPrincipal Investigator
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka University
Development of novels methods for single cell analysis of antigen specific cells
- Principal Investigator
  
  ウィングジェイムス
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Osaka University
Reestablishing immune tolerance and homeostasis in autoimmune and autoinflammatory diseases
- Principal Investigator
  
  竹田潔
- Project Period (FY)
  2022 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Leading Research )
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
制御性T細胞を用いた移植免疫制御方法の開発
- Principal Investigator
  
  宮川繁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka University
Study of the function and development of regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Shimon Sakaguchi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Molecular basis and therapeutic target for autoimmune arthritisPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Shimon
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Transplantation of islets in immune tolerance site under skin induced by bFGF or SEK-1005
- Principal Investigator
  
  IWATA Hiroo
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Mechanisms of regulatory T-cell control of humoral immunity
- Principal Investigator
  
  WING James
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
制御性Ｔ細胞による腫瘍内ＣＤ８＋Ｔ細胞の活性抑制に関する研究Principal Investigator
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Molecular basis of the function and generation of Foxp3-expressing regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Kyoto University
The establishment and clinical application of new immunotherapy for gynecologic cancers by using the activation of self-tolerance
- Principal Investigator
  
  TAKAKURA Kenji, 藤井信吾
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Immune tolerance and regulation towards understanding and cure of autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2001 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
BREAKING IMMUNOLOGICAL TOLERANCE TO TUMOR CELLS AS A NOVEL IMMUNOTHERAPY FOR CANCER
- Principal Investigator
  
  SHIMIZU Jun
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY
Roles of the Autoimmune Regulator (AIRE) Gene in Immune Response
- Principal Investigator
  
  SHIMIZU Nobuyoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
自己免疫性関節炎を自然発症するマウスモデルの確立とその解析Principal Investigator
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
自己免疫病発症の分子機構:自己反応性T細胞の制御機構についてPrincipal Investigator
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
発生工学的手法による自己免疫病発症機構の解析Principal Investigator
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine

[Book] 臨床免疫・アレルギー科　Vol75 No.32021
- Author(s)
  三上統久・坂口志文
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 週刊医学のあゆみVol.274 No.112020
- Author(s)
  大倉永也・坂口志文
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 実験医学　Vol.38 No.17（増刊）2020
- Author(s)
  三上統久・坂口志文
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 週刊医学のあゆみ　Vol.275 No.12020
- Author(s)
  三上統久・坂口志文
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16H06295
[Book] 臨床免疫・アレルギー科: 制御性 T 細胞によるTfh細胞および胚中心形成制御機構2015
- Author(s)
  Wing JB, Morita T, Sakaguchi S.
- Total Pages
  92
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25860356
[Book] Measuring Immunity2005
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Total Pages
  722
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CTLA-4 expression by B-1a B cells is essential for immune tolerance2021
- Author(s)
  Yang Yang、Li Xiao、Ma Zhihai、Wang Chunlin、Yang Qunying et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 525-525
- DOI
  10.1038/s41467-020-20874-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-18K07175
[Journal Article] Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases2020
- Author(s)
  Ohkura Naganari、Yasumizu Yoshiaki、Kitagawa Yohko、Tanaka Atsushi、Nakamura Yamami、Motooka Daisuke、Nakamura Shota、Okada Yukinori、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 52 Issue: 6 Pages: 1119-1132.e4
- DOI
  10.1016/j.immuni.2020.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function2020
- Author(s)
  Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 34 Pages: 20696-20705
- DOI
  10.1073/pnas.2000372117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19K18779, KAKENHI-PROJECT-19KK0202, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-20H03469, KAKENHI-PROJECT-18K16158, KAKENHI-PROJECT-20H03703, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-19K23868
[Journal Article] PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis2020
- Author(s)
  Hsieh Wan-Chen、Svensson Mattias N.D.、Zoccheddu Martina、Tremblay Michael L.、Sakaguchi Shimon、Stanford Stephanie M.、Bottini Nunzio
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 20
- DOI
  10.1172/jci.insight.141868
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression2020
- Author(s)
  Mikami Norihisa、Kawakami Ryoji、Sakaguchi Shimon
- Journal Title
  
  Current Opinion in Immunology
  
  Volume: 67 Pages: 36-41
- DOI
  10.1016/j.coi.2020.07.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation2020
- Author(s)
  Mikami Norihisa、Kawakami Ryoji、Chen Kelvin Y.、Sugimoto Atsushi、Ohkura Naganari、Sakaguchi Shimon
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 22 Pages: 12258-12268
- DOI
  10.1073/pnas.1922600117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Clinical importance of the expression of CD4+CD8+ T cells in Renal Cell Carcinoma.2020
- Author(s)
  Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H.
- Journal Title
  
  Int Immunol
  
  Volume: Jan24 Issue: 5 Pages: 347-357
- DOI
  10.1093/intimm/dxaa004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-16H06295
[Journal Article] Dynamics of effector and naive Regulatory T cells throughout pregnancy2020
- Author(s)
  Shigeta Naoya、Kumasawa Keiichi、Tanaka Atsushi、Badger Wing James、Nakamura Hitomi、Sakaguchi Shimon、Kimura Tadashi
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 140 Pages: 103135-103135
- DOI
  10.1016/j.jri.2020.103135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-19K09779, KAKENHI-PROJECT-16H06295
[Journal Article] VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data2020
- Author(s)
  Yasumizu Yoshiaki、Hara Atsushi、Sakaguchi Shimon、Ohkura Naganari
- Journal Title
  
  Bioinformatics
  
  Volume: btaa859 Issue: 10 Pages: 1465-1467
- DOI
  10.1093/bioinformatics/btaa859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.2020
- Author(s)
  Takeuchi Y, Hirota K, Sakaguchi S.
- Journal Title
  
  Immunol Rev.
  
  Volume: 294 Issue: 1 Pages: 164-176
- DOI
  10.1111/imr.12841
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06295
[Journal Article] Regulatory T Cells and Human Disease2020
- Author(s)
  Sakaguchi Shimon、Mikami Norihisa、Wing James B.、Tanaka Atsushi、Ichiyama Kenji、Ohkura Naganari
- Journal Title
  
  Annual Review of Immunology
  
  Volume: 38 Issue: 1 Pages: 541-566
- DOI
  10.1146/annurev-immunol-042718-041717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-18K07177, KAKENHI-PROJECT-16H06295
[Journal Article] Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy2020
- Author(s)
  Tay Christopher、Qian Yamin、Sakaguchi Shimon
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 1 Pages: 48-48
- DOI
  10.3390/cancers13010048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Tumour Grade Significantly Correlates With Total Dysfunction of Tumour Tissue-Infiltrating Lymphocytes in Renal Cell Carcinoma2020
- Author(s)
  Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Nishida K, Nojima S, Yamamoto Y, Kato T, Hatano K, Ujike T, Nagahara A, Fujita K, Morimoto-Okazawa A, Iwahori K, Uemura M, Imamura R, Ohkura N, Morii E, Sakaguchi S, Wada H, Nonomura N.
- Journal Title
  
  Sci Rep .
  
  Volume: 10 Issue: 1 Pages: 6220-6220
- DOI
  10.1038/s41598-020-63060-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-19K16557
[Journal Article] Control of foreign Ag‐specific Ab responses by Treg and Tfr2020
- Author(s)
  Wing James B.Lim Ee Lyn、Sakaguchi Shimon
- Journal Title
  
  Immunological Reviews
  
  Volume: 296 Issue: 1 Pages: 104-119
- DOI
  10.1111/imr.12888
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-16H06295
[Journal Article] Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases2020
- Author(s)
  Ohkura Naganari、Sakaguchi Shimon
- Journal Title
  
  Cell Research
  
  Volume: 30 Issue: 6 Pages: 465-474
- DOI
  10.1038/s41422-020-0324-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Strain-specific manifestation of lupus-like systemic autoimmunity caused by ZAP70 mutation2019
- Author(s)
  Takashi Matsuo, Motomu Hashimoto, Shimon Sakaguchi, Noriko Sakaguchi, Yoshinaga Ito, Masaki Hikida, Tatsuaki Tsuruyama, Kaoru Sakai, Hideki Yokoi, Mirei Shirakashi, Masao Tanaka, Hiromu Ito, Hajime Yoshifuji, Koichiro Ohmura, Takao Fujii, and Tsuneyo Mimori
- Journal Title
  
  The Journal of Immunology
  
  Volume: 印刷中 Issue: 11 Pages: 3161-3172
- DOI
  10.4049/jimmunol.1801159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09890, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-18H02926
[Journal Article] Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/192019
- Author(s)
  Akamatsu Masahiko、Mikami Norihisa、Ohkura Naganari、Kawakami Ryoji、Kitagawa Yohko、Sugimoto Atsushi、Hirota Keiji、Nakamura Naoto、Ujihara Satoru、Kurosaki Toshio、Hamaguchi Hisao、Harada Hironori、Xia Guliang、Morita Yoshiaki、Aramori Ichiro、Narumiya Shuh、Sakaguchi Shimon
- Journal Title
  
  Science Immunology
  
  Volume: 4 Issue: 40
- DOI
  10.1126/sciimmunol.aaw2707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] Control of Regulatory T Cells by Co-signal Molecules2019
- Author(s)
  Wing James Badger、Tay Christopher、Sakaguchi Shimon
- Journal Title
  
  Co-signal Molecules in T Cell Activation
  
  Volume: 1189 Pages: 179-210
- DOI
  10.1007/978-981-32-9717-3_7
- ISBN
  9789813297166, 9789813297173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-16H06295
[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.2019
- Author(s)
  Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
- Journal Title
  
  International immunology
  
  Volume: 31 Issue: 5 Pages: 335-347
- DOI
  10.1093/intimm/dxz008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06295
[Journal Article] Targeting Treg cells in cancer immunotherapy2019
- Author(s)
  Tanaka Atsushi、Sakaguchi Shimon
- Journal Title
  
  European Journal of Immunology
  
  Volume: 49 Issue: 8 Pages: 1140-1146
- DOI
  10.1002/eji.201847659
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation2019
- Author(s)
  Yasuda Keiko、Kitagawa Yohko、Kawakami Ryoji、Isaka Yoshitaka、Watanabe Hitomi、Kondoh Gen、Kohwi-Shigematsu Terumi、Sakaguchi Shimon、Hirota Keiji
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 549-549
- DOI
  10.1038/s41467-019-08404-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-16H06295
[Journal Article] Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells2019
- Author(s)
  Herppich S, Toker A, Pietzsch B, Kitagawa Y, Ohkura N, Miyao T, Floess S, Hori S, Sakaguchi S, Huehn J
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 2382-2382
- DOI
  10.3389/fimmu.2019.02382
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22526, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-19H04801, KAKENHI-PROJECT-18H04025
[Journal Article] Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance2019
- Author(s)
  Yamaguchi Tomoyuki、Teraguchi Shunsuke、Furusawa Chikara、Machiyama Hiroaki、Watanabe Tomonobu M、Fujita Hideaki、Sakaguchi Shimon、Yanagida Toshio
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 11 Pages: 743-753
- DOI
  10.1093/intimm/dxz043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06165, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H05746
[Journal Article] Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer2019
- Author(s)
  Wing James B.、Tanaka Atsushi、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 50 Issue: 2 Pages: 302-316
- DOI
  10.1016/j.immuni.2019.01.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295
[Journal Article] Functional Roles of the IgM Fc Receptor in the Immune System2019
- Author(s)
  Kubagawa Hiromi、Honjo Kazuhito、Ohkura Naganari、Sakaguchi Shimon、Radbruch Andreas、Melchers Fritz、Jani Peter K.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 945-945
- DOI
  10.3389/fimmu.2019.00945
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer2019
- Author(s)
  Kamada Takahiro、Togashi Yosuke、Tay Christopher、Ha Danbee、Sasaki Akinori、Nakamura Yoshiaki、Sato Eiichi、Fukuoka Shota、Tada Yasuko、Tanaka Atsushi、Morikawa Hiromasa、Kawazoe Akihito、Kinoshita Takahiro、Shitara Kohei、Sakaguchi Shimon、Nishikawa Hiroyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: In press Issue: 20 Pages: 9999-10008
- DOI
  10.1073/pnas.1822001116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18388, KAKENHI-PROJECT-19K22574, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-17H06162
[Journal Article] Synovial Tissue Inflammation Mediated by Autoimmune T Cells2019
- Author(s)
  Takeuchi Yusuke、Hirota Keiji、Sakaguchi Shimon
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1989-1989
- DOI
  10.3389/fimmu.2019.01989
- NAID
  120006726173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-19H01026, KAKENHI-PROJECT-17K19553
[Journal Article] Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.2019
- Author(s)
  Matoba T, Imai M, Ohkura N, Kawakita D, Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 144(11) Issue: 11 Pages: 2811-2822
- DOI
  10.1002/ijc.32024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18006, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05798, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17K16937, KAKENHI-PROJECT-19KK0202, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-17K11679
[Journal Article] Control of Germinal Center Responses by T-Follicular Regulatory Cells2018
- Author(s)
  Wing James B.、Tekguc Murat、Sakaguchi Shimon
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1910-1917
- DOI
  10.3389/fimmu.2018.01910
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-16H06295
[Journal Article] Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis.2018
- Author(s)
  Napier RJ, Lee EJ, Vance EE, Snow PE, Samson KA, Dawson CE, Moran AE, Stenzel P, Davey MP, Sakaguchi S, Rosenzweig HL.
- Journal Title
  
  J. Immunol.
  
  Volume: 201 Issue: 7 Pages: 1889-1898
- DOI
  10.4049/jimmunol.1700507
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis2018
- Author(s)
  Hirota Keiji、Hashimoto Motomu、Ito Yoshinaga、Matsuura Mayumi、Ito Hiromu、Tanaka Masao、Watanabe Hitomi、Kondoh Gen、Tanaka Atsushi、Yasuda Keiko、Kopf Manfred、Potocnik Alexandre J.、Stockinger Brigitta、Sakaguchi Noriko、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 48 Issue: 6 Pages: 1220-1232
- DOI
  10.1016/j.immuni.2018.04.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19553, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-17K15723
[Journal Article] Are naive T cells and class-switched memory (IgD- CD27+) B cells not essential for establishment and maintenance of pregnancy? Insights from a case of common variable immunodeficiency with pregnancy.2018
- Author(s)
  Shigeta Naoya、Nakamura Hitomi、Kumasawa Keiichi、Imai Kohsuke、Saito Shigeru、Sakaguchi Shimon、Kimura Tadashi
- Journal Title
  
  Medical Hypotheses
  
  Volume: 121 Pages: 36-41
- DOI
  10.1016/j.mehy.2018.09.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-16H06295
[Journal Article] Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody2018
- Author(s)
  Ha Danbee、Tanaka Atsushi、Kibayashi Tatsuya、Tanemura Atsushi、Sugiyama Daisuke、Wing James Badger、Lim Ee Lyn、Teng Karen Wei Weng、Adeegbe Dennis、Newell Evan W.、Katayama Ichiro、Nishikawa Hiroyoshi、Sakaguchi Shimon
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 2 Pages: 609-618
- DOI
  10.1073/pnas.1812186116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-18K08267, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-17H06162
[Journal Article] Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.2018
- Author(s)
  Fuchs A, Gliwinski M, Grageda N, et al.
- Journal Title
  
  Front Immunol.
  
  Volume: 8 Pages: 1844-1844
- DOI
  10.3389/fimmu.2017.01844
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis.2018
- Author(s)
  Ikeno Y, Seo S, Iwaisako K, Yoh T, Nakamoto Y, Fuji H, Taura K, Okajima H, Kaido T, Sakaguchi S, Uemoto S
- Journal Title
  
  J Transl Med.
  
  Volume: 16 Issue: 1 Pages: 95-95
- DOI
  10.1186/s12967-018-1475-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10510, KAKENHI-PROJECT-16H06295
[Journal Article] Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.2018
- Author(s)
  Sekido Y, Yasumizu Y, Nishimura J, Kayama H, Matsuno H, Ogino T, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Takeda K, Ohkura N, Sakaguchi S, Mizushima T.
- Journal Title
  
  Digestion
  
  Volume: 19: Issue: 3 Pages: 1-11
- DOI
  10.1159/000490890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-17K16546
[Journal Article] Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2018
- Author(s)
  Hashimoto Takashi、Takahashi Hayato、Sakaguchi Shimon
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 142 Issue: 6 Pages: 1754-1756
- DOI
  10.1016/j.jaci.2018.08.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08275, KAKENHI-PROJECT-16H06295
[Journal Article] Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated with a Novel Cyclic Peptide without Immunosuppressive Medication2018
- Author(s)
  Kuwabara Rei、Hamaguchi Masahide、Fukuda Takuya、Sakai Hiroki、Inui Makoto、Sakaguchi Shimon、Iwata Hiroo
- Journal Title
  
  Transplantation
  
  Volume: 102 Issue: 3 Pages: 417-425
- DOI
  10.1097/tp.0000000000001923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15203, KAKENHI-PROJECT-17H01579, KAKENHI-PROJECT-17H04033, KAKENHI-PROJECT-16J06573, KAKENHI-PROJECT-16H06295
[Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.2017
- Author(s)
  Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 7 Pages: 1824-1838
- DOI
  10.1016/j.celrep.2017.10.082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08838, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-17H04190, KAKENHI-PROJECT-15K08274
[Journal Article] Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.2017
- Author(s)
  Carrascosa CL, Klein M, Kitagawa Y, Luckel C, Marini F, Konig A, Guralnik A, Raifer H, Hagner S, Raedler D, Bock A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15366-15366
- DOI
  10.1038/ncomms15366
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Novel interferon-γ enzyme-linked immunoSpot assay using activated cells for identifying hypersensitivity-inducing drug culprits.2017
- Author(s)
  Kato K, Kawase A, Azukizawa H, Hanafusa T, Nakagawa Y, Murota H, Sakaguchi S, Asada H, Katayama I
- Journal Title
  
  J Dermatol Sci
  
  Volume: 86 Issue: 3 Pages: 222-229
- DOI
  10.1016/j.jdermsci.2017.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461699, KAKENHI-PROJECT-16K10134, KAKENHI-PROJECT-17K10250, KAKENHI-PROJECT-16H06295
[Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin2017
- Author(s)
  Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 200 Issue: 1 Pages: 119-129
- DOI
  10.4049/jimmunol.1701056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-17K11679, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05798, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-16K15259, KAKENHI-PROJECT-16K15376, KAKENHI-PROJECT-17H04242
[Journal Article] UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses.2017
- Author(s)
  Sasaki, N., T. Yamashita, K. Kasahara, A. Fukunaga, T. Yamaguchi, T. Emoto, K. Yodoi, T. Matsumoto, K. Nakajima, T. Kita, M. Takeda, T. Mizoguchi, T. Hayashi, Y. Sasaki, M. Hatakeyama, K. Taguchi, K. Washio, S. Sakaguchi, B. Malissen, C. Nishigori, and K.I. Hirata
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 37(1) Issue: 1 Pages: 66-74
- DOI
  10.1161/atvbaha.116.308063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08530, KAKENHI-PROJECT-15K09156, KAKENHI-PROJECT-16K09516, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15K09742
[Journal Article] Regulatory T cells in cancer immunotherapy2017
- Author(s)
  Tanaka, A., and Sakaguchi, S.
- Journal Title
  
  Cell Research
  
  Volume: 27 Issue: 1 Pages: 109-118
- DOI
  10.1038/cr.2016.151
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331, KAKENHI-PROJECT-17K15723, KAKENHI-PROJECT-16H06295
[Journal Article] Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.2017
- Author(s)
  Kitagawa Y, Ohkura N, Kidani Y, Vandenbon A, Hirota K, Kawakami R, Yasuda K, Motooka D, Nakamura S, Kondo M, Taniuchi I, Kohwi-Shigematsu T, Sakaguchi S.
- Journal Title
  
  Nat Immunol.
  
  Volume: 18(2) Issue: 2 Pages: 173-183
- DOI
  10.1038/ni.3646
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-16K14650, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05805
[Journal Article] ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori.2017
- Author(s)
  長瀬博次
- Journal Title
  
  Int J Cancer
  
  Volume: 140(3) Issue: 3 Pages: 686-695
- DOI
  10.1002/ijc.30475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19892, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-26290054
[Journal Article] Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.2017
- Author(s)
  Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.
- Journal Title
  
  Oncotarget.
  
  Volume: 8(22) Issue: 22 Pages: 35542-35557
- DOI
  10.18632/oncotarget.16221
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05789, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-15H04747
[Journal Article] Systemic activation of NRF2 alleviates lethal autoimmune inflammation in Scurfy mice2017
- Author(s)
  Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H
- Journal Title
  
  Mol Cell Biol
  
  Volume: 37 Issue: 15
- DOI
  10.1128/mcb.00063-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-16H06295, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-17F17116
[Journal Article] T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.2017
- Author(s)
  Glatman Zaretsky A, Konradt C, Depis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, Cancro MP, Sakaguchi S, Lu LF, Benoist CO, Hunter CA.
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 8 Pages: 906-916
- DOI
  10.1016/j.celrep.2017.01.067
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19129, KAKENHI-PROJECT-16H06295
[Journal Article] Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.2017
- Author(s)
  Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A.
- Journal Title
  
  J Immunol.
  
  Volume: 199 Issue: 6 Pages: 2008-2019
- DOI
  10.4049/jimmunol.1700157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19596, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H06004, KAKENHI-PROJECT-15H04296, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-15K08423
[Journal Article] Molecular control of regulatory T cell development and function.2017
- Author(s)
  Kitagawa Y, Sakaguchi S.
- Journal Title
  
  Curr Opin Immunol.
  
  Volume: 49 Pages: 64-70
- DOI
  10.1016/j.coi.2017.10.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells.2016
- Author(s)
  Miyara M, Chader D, Burlion A, Goldstein J, Sterlin D, Norol F, Trebeden-Negre H, Claer L, Sakaguchi S, Marodon G, Amoura Z, Gorochov G.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Issue: 62 Pages: 104733-104744
- DOI
  10.18632/oncotarget.10914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system.2016
- Author(s)
  Vandenbon A, Dinh VH, Mikami N, Kitagawa Y, Teraguchi S, Ohkura N, Sakaguchi S.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113(17) Issue: 17
- DOI
  10.1073/pnas.1604351113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H06295
[Journal Article] Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.2016
- Author(s)
  Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R.
- Journal Title
  
  J Immunol
  
  Volume: 197 Issue: 2 Pages: 429-40
- DOI
  10.4049/jimmunol.1502656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Advertisement Hypomethylation of the Treg-specific demethylated region in FOXP3 is a hallmark of the regulatory T-cell subtype in adult T-cell leukemia2016
- Author(s)
  Shimazu Y, Shimazu Y, Hishizawa M, Hamaguchi M, Nagai Y, Sugino N, Fujii S, Kawahara M, Kadowaki N, Nishikawa H, Sakaguchi S, Takaori-Kondo A.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 4 Pages: 136-145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine.2016
- Author(s)
  Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 68 Issue: 11 Pages: 2646-2661
- DOI
  10.1002/art.39783
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-16H06233, KAKENHI-PROJECT-15K15152, KAKENHI-PROJECT-26670477, KAKENHI-PROJECT-16K08838, KAKENHI-PROJECT-16K14650, KAKENHI-PROJECT-16H06295
[Journal Article] Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.2016
- Author(s)
  Saito, T., Nishikawa, H., Wada, H., Nagano, Y., Sugiyama, D., Atarashi, K., Maeda, Y., Hamaguchi, M., Ohkura, N., Sato, E., Nagase, H., Nishimura, J., Yamamoto, H., Takiguchi, S., Tanoue, T., Suda, W., Morita, H., Hattori, M., Honda, K., Mori, M., Doki, Y., Sakaguchi, S.
- Journal Title
  
  Nat. Med
  
  Volume: 22 Issue: 6 Pages: 679-684
- DOI
  10.1038/nm.4086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-15H06878, KAKENHI-PROJECT-15H06880, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-26290054
[Journal Article] Utility of CD127 combined with FOXP3 for identification of operational tolerance after liver transplantation.2016
- Author(s)
  Nafady-Hego H, Li Y, Ohe H, Elgendy H, Zhao X, Sakaguchi S, Bishop GA, Koshiba T.
- Journal Title
  
  Transplant Immunology
  
  Volume: 36 Pages: 1-8
- DOI
  10.1016/j.trim.2016.04.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Identification of novel and noninvasive biomarkers of acute cellular rejection after liver transplantation by protein microarray2016
- Author(s)
  Okubo, K., Wada, H., Tanaka, A., Eguchi, E., Hamaguchi, M., Tomokuni, A., Tomimaru, Y., Asaoka, T., Hama, N., Kawamoto, K., Kobayashi, S., Marubashi, S., Nagano, H., Sakaguchi, N., Nishikawa, H., Doki, Y., Mori, M., Sakaguchi, S.
- Journal Title
  
  Transplant Direct
  
  Volume: 2 Issue: 12 Pages: e118-e118
- DOI
  10.1097/txd.0000000000000630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860331, KAKENHI-PROJECT-16H06295
[Journal Article] Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T cell leukemia.2016
- Author(s)
  Ureshino H, Shindo T, Nishikawa H, Watanabe N, Watanabe E, Satoh N, Kitaura K, Kitamura H, Doi K, Nagase K, Kimura H, Samukawa M, Kusunoki S, Miyahara M, Shin-I T, Suzuki R, Sakaguchi S, Kimura S.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 4 Pages: 644-649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.2016
- Author(s)
  Klocke K, Sakaguchi S, Holmdahl R, Wing K.
- Journal Title
  
  PNAS
  
  Volume: 113(17) Issue: 17
- DOI
  10.1073/pnas.1603892113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Journal Article] The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis.2016
- Author(s)
  Morita T, Shima Y, Wing JB, Sakaguchi S, Ogata A, Kumanogoh A
- Journal Title
  
  PLOS one
  
  Volume: 11 Issue: 9 Pages: e0162306-e0162306
- DOI
  10.1371/journal.pone.0162306
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19129, KAKENHI-PROJECT-16H06295
[Journal Article] Antibody to CMRF35-Like Molecule 2, CD300e A Novel Biomarker Detected in Patients with Fulminant Type 1 Diabetes.2016
- Author(s)
  Haseda F, Imagawa A, Nishikawa H, Mitsui S, Tsutsumi C, Fujisawa R, Sano H, Murase-Mishiba Y, Terasaki J, Sakaguchi S, Hanafusa T.
- Journal Title
  
  PLOS ONE
  
  Volume: 11 Issue: 8 Pages: e0160576-e0160576
- DOI
  10.1371/journal.pone.0160576
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09402, KAKENHI-PROJECT-16K15551, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-26290054
[Journal Article] In vivo induction of T-follicular helper cells by modulation of regulatory T cell function.2015
- Author(s)
  Wing , JB. Sakaguchi, S.
- Journal Title
  
  Methods in molecular biology.
  
  Volume: 1291 Pages: 77-85
- DOI
  10.1007/978-1-4939-2498-1_7
- ISBN
  9781493924974, 9781493924981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860356
[Journal Article] Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans.2015
- Author(s)
  Miyara M, Chader D, Sage E, Sugiyama D, Nishikawa H, Bouvry D, Claër L, Hingorani R, Balderas R, Rohrer J, Warner N, Chapelier A, Valeyre D, Kannagi K, Sakaguchi S, Amoura Z, Gorochov G.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 112 Pages: 7225-7230
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] The microbiota regulates type 2 immunity through RORt+ T cells.2015
- Author(s)
  Ohnmacht C, Park J, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G.
- Journal Title
  
  Science.
  
  Volume: 349 Pages: 989-993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Transcriptional and epigenetic control of regulatory T cell development.2015
- Author(s)
  Kitagawa Y, Wing JB, Sakaguchi S.
- Journal Title
  
  Prog Mol Biol Transl Sci.
  
  Volume: 136 Pages: 1-33
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Foxp3⁺ T(reg) cells in humoral immunity.2014
- Author(s)
  Wing JB, Sakaguchi S.
- Journal Title
  
  Int Immunol.
  
  Volume: 26(2) Issue: 2 Pages: 61-9
- DOI
  10.1093/intimm/dxt060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860356
[Journal Article] TREG-cell therapies for autoimmune rheumatic diseases.2014
- Author(s)
  Miyara M, Ito Y, Sakaguchi S.
- Journal Title
  
  Nat Rev Rheumatol.
  
  Volume: 10 Pages: 543-551
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Schmidt-Supprian M. Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool2014
- Author(s)
  Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, RieB D, Hein MY, Buch T, Polic B, Schonle A, Zeiser R, Schmitt-Graff A, Kretschmer K, Klein L, Korn T, Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume: 41 Pages: 722-736
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer.2014
- Author(s)
  Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sakaguchi S, Roers A, Miiller W, Hansen W, Buer J, Westendorf AM.
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Pages: 4258-4269
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.2014
- Author(s)
  Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nago-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest A, Standley D, Date D, Sakaguchi S, and the FANTOM consortium.
- Journal Title
  
  PNAS
  
  Volume: 111 Pages: 5289-5294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] CD8+ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma2014
- Author(s)
  Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, Ono M, Matsumura Y, Kato M, Konishi K, Shiga T, Sano S, Sakaguchi S, Miyagawa-Hayashino A, Takahashi K, Uezato H, Miyachi Y, Tanioka M.
- Journal Title
  
  Int J Cancer
  
  Volume: 134 Pages: 2393-2402
- NAID
  120005458273
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Autosomal dominant immune dysregulation syndrome in humans with CTLA-4 mutations.2014
- Author(s)
  Schubert D, et al.
- Journal Title
  
  Nature Med.
  
  Volume: 20 Issue: 12 Pages: 1410-1416
- DOI
  10.1038/nm.3746
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25121727, KAKENHI-PROJECT-25440031, KAKENHI-PROJECT-25860356
[Journal Article] Genetic and epigenetic basis of Treg cell development and function: From a FoxP3-centered view to an epigenome-defined view of natural Treg cells2014
- Author(s)
  Morikawa H, Sakaguchi S.
- Journal Title
  
  Immunol. Rev
  
  Volume: 259 Pages: 192-205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] A promoter level mammalian expression atlas.2014
- Author(s)
  Forrest A, ..., Morikawa H., ..., Hamaguchi M., ..., Ohkura N., ...,Sakaguchi S., ...,Hayashizaki Y, et al.,
- Journal Title
  
  Nature
  
  Volume: 507 Pages: 462-470
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Regulatory T cells in cancer immunotherapy.2014
- Author(s)
  Nishikawa H, Sakaguchi S.
- Journal Title
  
  Curr Opin Immunol.
  
  Volume: 27 Pages: 1-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.2014
- Author(s)
  Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
- Journal Title
  
  Immunity
  
  Volume: 41 Issue: 6 Pages: 1013-25
- DOI
  10.1016/j.immuni.2014.12.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860356, KAKENHI-PROJECT-26221306
[Journal Article] CD28 signals the differential control of regulatory T cells and effector T cells.2014
- Author(s)
  Mikami N, Sakaguchi S.
- Journal Title
  
  Eur J Immunol
  
  Volume: 44 Pages: 955-957
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Comprehensive exploration of autoantibody in Behçet's disease: A novel autoantibody to claudin-1, an essential protein for tight junctions, is identified.2014
- Author(s)
  Morishima A, Hirano T, Nishikawa H, Nakai K, Sakaguchi S, Kumanogoh A.
- Journal Title
  
  Joint Bone Spine.
  
  Volume: 81 Pages: 546-548
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Interleukin-10- Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation2014
- Author(s)
  Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, Kallies A, Nutt SL, Sakaguchi S, Takeda K, Kurosaki T, and Baba Y.
- Journal Title
  
  Immunity
  
  Volume: 41 Pages: 1040-1051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals2014
- Author(s)
  Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Pages: 1536-1540
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Detection of self-reactive CD8⁺ T cells with an anergic phenotype in healthy individuals.2014
- Author(s)
  Maeda Y, Nishikawa H, Sugiyama D, Ha D, Hamaguchi M, Saito T, Nishioka M, Wing JB, Adeegbe D, Katayama I, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Issue: 6216 Pages: 1536-40
- DOI
  10.1126/science.aaa1292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860356, KAKENHI-PROJECT-26290054, KAKENHI-PROJECT-26670581
[Journal Article] Homeostasis of Thymus-Derived Foxp3+ Regulatory T Cells Is Controlled by Ultraviolet B Exposure in the Skin.2014
- Author(s)
  Yamazaki S, Nishioka A, Kasuya S, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A.
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 5488-5497
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease2014
- Author(s)
  Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
- Journal Title
  
  Science
  
  Volume: 346 Pages: 363-368
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Foxp3+ Treg cells in humoral immunity.2014
- Author(s)
  Wing JB, Sakaguchi S.
- Journal Title
  
  Int Immunol.
  
  Volume: 26 Pages: 61-69
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Regulatory T-cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-42014
- Author(s)
  Wing JB, Ise W, Kurosaki T, Sakaguchi S.
- Journal Title
  
  Immunity
  
  Volume: 41 Pages: 1013-1025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Epigenetic control of thymic Treg-cell development.2014
- Author(s)
  Kitagawa Y, Ohkura N, Sakaguchi S.
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 45 Pages: 11-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] FRT - Fondation Rene Touraine: Pour La Dermatologie.2014
- Author(s)
  Sakaguchi S, Sallusto F, Gebhardt T, Stingl G, Clark RA, Santamaria-Babí LF, Guttman-Yassky E, Schuler G, Koenen HJ.
- Journal Title
  
  Exp Dermatol
  
  Volume: 23 Pages: 772-785
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253030
[Journal Article] Development and Maintenance of Regulatory T cells.2013
- Author(s)
  Ohkura N, Kitagawa Y, Sakaguchi S.
- Journal Title
  
  Immunity
  
  Volume: 38 Pages: 414-423
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes2013
- Author(s)
  Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, Shiku H.
- Journal Title
  
  Eur J Immunol
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] .Pregnancy amelioration of arthritis in SKG mice corresponds with alterations in serum amyloid A3 levels2012
- Author(s)
  Shaw LA, Stefanski AL, Peterson LK, Rumer KK, Vondracek A, Phang TL, Sakaguchi S, Winn VD, Dragone LL
- Journal Title
  
  Am J Clin Exp Immunol
  
  Volume: 1 Pages: 12-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Treg cells acquire new directions, cytokines navigate2012
- Author(s)
  Ohkura N, Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume: 37 Pages: 443-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Re-establishing immunological self-tolerance in autoimmune disease2012
- Author(s)
  Sakaguchi, S., Powrie, F., Ransohoff, R. M
- Journal Title
  
  Nat Med
  
  Volume: 18 Pages: 54-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.2012
- Author(s)
  Sakaguchi, S., Benham, H., Cope,A. P., Thomas, R.
- Journal Title
  
  Immunol Cell Biol.
  
  Volume: 90 Pages: 277-87
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two modes of immune suppression by Foxp3(十) regulatory T cells under inflammatory or non-inflammatory conditions2012
- Author(s)
  Yamaguchi, T., Wing, J.B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol
  
  Volume: 23 Pages: 424-430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.2012
- Author(s)
  Nishikawa, H., Maeda, Y., Ishida, T.,Gnjatic, S., Sato, E., Mori, F.,Sugiyama, D., Ito, A., Fukumori, Y., Utsunomiya, A., Inagaki, H., Old, L. J., Ueda, R., and Sakaguchi, S.
- Journal Title
  
  Blood.
  
  Volume: 119 Pages: 3097-3104
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] A Novel Model of Rheumatoid Arthritis-Associated Interstitial Lung Disease in SKG Mice2012
- Author(s)
  Keith, R. C., Powers, J. L., Redente, E. F., Sergew, A., Martin, R. J., Gizinski, A., Holers, V. M., Sakaguchi, S., Riches, D. W
- Journal Title
  
  Exp Lung Res
  
  Volume: 38 Pages: 55-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation2012
- Author(s)
  Yoshioka, Y., Ono, M., Osaki, M., Konishi, I., Sakaguchi, S.
- Journal Title
  
  Eur J Immunol
  
  Volume: 42 Pages: 749-759
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T.Factors affecting operational tolerance after pediatric living-donor liver transplantation : impact of early post-transplant events and HLA match2012
- Author(s)
  Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda, N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G.A., Koshiba, T.
- Journal Title
  
  Transpl Int
  
  Volume: 25 Pages: 97-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.2012
- Author(s)
  Noguchi, T., Kato, T., Wang, L., Maeda,Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., and Nishikawa, H
- Journal Title
  
  Cancer Res.
  
  Volume: 72 Pages: 1672-1682
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Re-establishingimmunological self- tolerance in autoimmune disease.2012
- Author(s)
  Sakaguchi, S., Powrie, F., Ransohoff, R. M.
- Journal Title
  
  Nat Med.
  
  Volume: 18 Pages: 54-58
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for Treg cell development.2012
- Author(s)
  Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S.
- Journal Title
  
  Immunity.
  
  Volume: 37 Pages: 785-99
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man2012
- Author(s)
  Sakaguchi, S., Benham, H., Cope, A. P., Thomas, R
- Journal Title
  
  Immunol Cell Biol
  
  Volume: 90 Pages: 277-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
- Journal Title
  
  J Immunol
  
  Volume: 189 Pages: 2869-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth2012
- Author(s)
  Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I
- Journal Title
  
  J Exp Med
  
  Volume: 209 Pages: 2001-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple treg suppressive modules and their adaptability2012
- Author(s)
  Wing JB, Sakaguchi S
- Journal Title
  
  Front Immunol
  
  Volume: 3 Pages: 178-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for Treg cell development2012
- Author(s)
  Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume: 37 Pages: 785-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match2012
- Author(s)
  Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda, N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G. A., Koshiba, T.
- Journal Title
  
  Transpl Int
  
  Volume: 25 Pages: 97-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy2012
- Author(s)
  Noguchi, T., Kato, T., Wang, L., Maeda, Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., and Nishikawa, H
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 1672-1682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Factors affecting operational tolerance after pediatric living-donor liver transplantation: impact of early post-transplant events and HLA match.2012
- Author(s)
  Ohe, H., Waki, K., Yoshitomi, M., Morimoto, T., Nafady-Hego, H., Satoda,N., Li, Y., Zhao, X., Sakaguchi, S., Uemoto, S., Bishop, G. A., Koshiba, T
- Journal Title
  
  Transpl Int.
  
  Volume: 25 Pages: 97-106
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma2012
- Author(s)
  Nishikawa, H., Maeda, Y., Ishida, T., Gnjatic, S., Sato, E., Mori, F., Sugiyama, D., Ito, A., Fukumori, Y., Utsunomiya, A., Inagaki, H., Old, L. J., Ueda, R., and Sakaguchi, S
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 3097-3104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells expressing PPAR-γ control inflammation in obesity2012
- Author(s)
  Hamaguchi M, Sakaguchi S
- Journal Title
  
  Cell Metab
  
  Volume: 16 Pages: 4-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T-cell receptor signaling and the pathogenesis of autoimmune arthritis : insights from mouse and man2012
- Author(s)
  Sakaguchi, S., Benham, H., Cope, A.P., Thomas, R.
- Journal Title
  
  Immunol Cell Biol
  
  Volume: 90 Pages: 277-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth2012
- Author(s)
  Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I.
- Journal Title
  
  J Exp Med.
  
  Volume: 209 Pages: 2001-16
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] The long-term survival potential of mature T lymphocytes is programmed during development in the thymus2012
- Author(s)
  Sinclair, C, Saini, M., van der Loeff, I.S., Sakaguchi, S., Seddon, B.
- Journal Title
  
  Sci Signal
  
  Volume: 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple treg suppressive modules and their adaptability.2012
- Author(s)
  Wing JB, Sakaguchi S
- Journal Title
  
  Front Immunol.
  
  Volume: 3 Pages: 178-178
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Thymus, innate immunity and autoimmune arthritis : interplay of gene and environment2012
- Author(s)
  Sakaguchi, S., Tanaka, S., Tanaka, A., Ito, Y., Maeda, S., Sakaguchi, N., Hashimoto, M.
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 3633-3639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] SLAP Deficiency Enhances Number and Function of Tregs Preventing Chronic Autoimmune Arthritis in SKG Mice2012
- Author(s)
  Peterson, L.K., Shaw, L.A., Joetham, A., Sakaguchi, S., Gelf, E.W., Dragone, L.L.
- Journal Title
  
  J.Immunol.
  
  Volume: 186 Pages: 2273-2281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.2012
- Author(s)
  Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K.
- Journal Title
  
  J Immunol.
  
  Volume: 189 Pages: 2869-78
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens2011
- Author(s)
  Cote, A.L., Zhang, P., O'Sullivan, J.A., Jacobs, V.L., Clemis, C.R., Sakaguchi, S., Guevara-Patino, J.A., Turk, M.J.
- Journal Title
  
  J.Immunol
  
  Volume: 186 Pages: 275-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells: history and perspective.2011
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Methods in Molecular Biology.
  
  Volume: 77 Pages: 1-13
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Maturation of effector regulatory T cells2011
- Author(s)
  Ohkura, N., Sakaguchi, S.
- Journal Title
  
  Nat Immunol
  
  Volume: 12 Pages: 283-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CSF-1-dependent red pulp macrophages regulate CD4 T cell responses2011
- Author(s)
  Kurotaki, D., Kon, S., Bae, K., Ito, K., Matsui, Y., Nakayama, Y., Kanayama, M., Kimura, C., Narita, Y., Nishimura, T., Iwabuchi, K., Mack, M., van Rooijen, N., Sakaguchi, S., Uede, T., Morimoto, J.
- Journal Title
  
  J.Immunol
  
  Volume: 186 Pages: 2229-2237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] SLAP Deficiency Enhances Number and Function of Tregs Preventing Chronic Autoimmune Arthritis in SKG Mice.2011
- Author(s)
  Peterson, L. K., Shaw, L. A., Joetham, A., Sakaguchi, S., Gelfand, E. W.,and Dragone, L. L.
- Journal Title
  
  J. Immunol.
  
  Volume: 186 Pages: 1173-1181
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] TCR diversity and Treg cells, sometimes more is more2011
- Author(s)
  Wing, J.B., Sakaguchi, S.
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Pages: 3097-3100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Minimal but essential doses of immunosuppression: A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation2011
- Author(s)
  Ohe, H., Li, Y., Nafady-Hego, H., Kayo, W., Sakaguchi, S., Wood, K., Calne,R., Uemoto, S., Koshiba, T.
- Journal Title
  
  Transplantation
  
  Volume: 91 Pages: 808-810
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Human FoxP3(+) regulatory T cells in systemic autoimmune diseases2011
- Author(s)
  Miyara, M., Gorochov, G., Ehrenstein, M., Musset, L., Sakaguchi, S., Amoura, Z.
- Journal Title
  
  Autoimmun.Rev
  
  Volume: 10 Pages: 744-755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P.L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog
  
  Volume: 7(2)
- NAID
  120002807462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] FoxP3+CD4+ regulatory T cells: their knowns and unknowns.2011
- Author(s)
  Miyara, M., and Sakaguchi, S
- Journal Title
  
  Immunol. Cell. Biology.
  
  Volume: 89 Pages: 346-351
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Trends Immunol.
  
  Volume: 32 Pages: 428-43
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions2011
- Author(s)
  Yamaguchi, T., Wing, J. B., Sakaguchi, S.
- Journal Title
  
  Semin Immunol.
  
  Volume: 23 Pages: 424-430
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Pillars Article : Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases2011
- Author(s)
  Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M.
- Journal Title
  
  J.Immunol
  
  Volume: 186 Pages: 3808-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] FOXP3(+) regulatory T cells: control of FOXP3 expression by pharmacological agents2011
- Author(s)
  3633-3639, 2011.18. Ohkura, N., Hamaguchi, M., Sakaguchi, S.
- Journal Title
  
  Trends Pharmacol. Sci.
  
  Volume: 32 Pages: 158-66
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] The long-term survival potential of mature T lymphocytes is programmed during development in the thymus.2011
- Author(s)
  Sinclair, C., Saini, M., van der Loeff, I. S., Sakaguchi, S., Seddon, B
- Journal Title
  
  Sci Signal.
  
  Volume: 4(199)
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Minimal but essential doses of immunosuppression : A more realistic approach to improve long-term outcomes for pediatric living-donor liver transplantation2011
- Author(s)
  Ohe, H., Li, Y, Nafady-Hego, H., Kayo, W., Sakaguchi, S., Wood, K., Calne, R., Uemoto, S., Koshiba, T.
- Journal Title
  
  Transplantation
  
  Volume: 91 Pages: 808-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011
- Author(s)
  Satou, Y., Yasunaga, J., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., Matsuoka, M.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 7(2)
- NAID
  120002807462
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Cell-autonomous and -nonautonomous functions of CTLA-4 for negative control of immune responses2011
- Author(s)
  Wing, K., Yamaguchi, T, Sakaguchi, S.
- Journal Title
  
  Trends Immunol
  
  Volume: 32 Pages: 428-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Human FoxP3(+) regulatory T cells in systemic autoimmune diseases2011
- Author(s)
  Miyara, M., Gorochov, G., Ehrenstein, M., Musset, L., Sakaguchi,S., Amoura, Z.
- Journal Title
  
  Autoimmun. Rev
  
  Volume: 10 Pages: 744-755
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : history and perspective2011
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 77 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Stimulation of the glucocorticoid- induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens.2011
- Author(s)
  Cote, A. L., Zhang, P., O'Sullivan,J. A., Jacobs, V. L., Clemis, C. R., Sakaguchi, S., Guevara-Patino, J. A., and Turk, M. J.
- Journal Title
  
  J. Immunol.
  
  Volume: 186 Pages: 275-283
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] innate immunity and autoimmune arthritis: interplay of gene and environment.2011
- Author(s)
  Sakaguchi, S., Tanaka, S., Tanaka,A., Ito, Y., Maeda, S., Sakaguchi, N., Hashimoto, M. Thymus
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Pages: 3633-3639
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] FoxP3+CD4+ regulatory T cells : their knowns and unknowns2011
- Author(s)
  Miyara, M., Sakaguchi, S.
- Journal Title
  
  Immunol.Cell.Biology
  
  Volume: 89 Pages: 346-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Histological changes in chronic autoimmune SKG-arthritis evaluated by quantitative three-dimensional stereological estimators2011
- Author(s)
  Keller, K.K., Stengaard-Pedersen, K., Dagnass-Hansen, F., Nyengaard, J.R., Sakaguchi, S., Hauge, E.M.
- Journal Title
  
  Clin.Exp.Rheumatol
  
  Volume: 29 Pages: 536-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Damping by depletion2011
- Author(s)
  Sakaguchi, S., Wing K.
- Journal Title
  
  Science
  
  Volume: 332 Pages: 542-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Perturbations of both non-regulatory and regulatory FOXP3(+) T cells in patients with malignant melanoma.2010
- Author(s)
  Fujii, H., Arakawa, A., Kitoh, A., Miyara, M., Kato, M., Kore-Eda, S., Sakaguchi, S., Miyachi, Y., Tanioka, M., and Ono, M.
- Journal Title
  
  Br. J. Dermatol.
  
  Volume: 164 Pages: 1052-1060
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : history and perspective.2010
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 77 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4+ T Cell Responses Enhances Antiparasitic Immunity.2010
- Author(s)
  Haque, A., Stanley, A. C., Amante,F. H., Rivera, F. D., Zhou, Y., Kuns, R. D., Yardley, V., Sakaguchi, S., Hill, G. R., and Engwerda, C. R
- Journal Title
  
  J. Immunol.
  
  Volume: 184 Pages: 2583-2592
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells exert checks and balances on self-tolerance and autoimmunity.2010
- Author(s)
  Wing, K., and Sakaguchi, S.Regulatory T cells exert checks and
- Journal Title
  
  Nat. Immunol
  
  Volume: 11 Pages: 7-13
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Perturbations of both non-regulatory and regulatory FOXP3(+) T cells in patients with malignant melanoma.2010
- Author(s)
  Fujii, H., Arakawa, A., Kitoh, A., Miyara, M., Kato, M., Kore-Eda, S., Sakaguchi, S., Miyachi, Y., Tanioka, M., Ono, M.
- Journal Title
  
  Br.J.Dermatol.doi
  
  Volume: 10.1111 Pages: 1365-2133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.2010
- Author(s)
  Tanaka, S., Maeda, S., Hashimoto. M., Teradaira, S., Hirota,K., Yoshitomi, H., Katakai, T., Shimizu, A., Nomura, T., Sakaguchi, N., and Sakaguchi, S.
- Journal Title
  
  J. Immunol.
  
  Volume: 185 Pages: 2295-305
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.2010
- Author(s)
  Snell, L.M., McPherson, A.J., Lin, G.H., Sakaguchi, S., Pandolfi, P.P., Riccardi, C., Watts, T.H.
- Journal Title
  
  J.Immunol
  
  Volume: 185 Pages: 7223-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells in tumor immunity.2010
- Author(s)
  Nishikawa, H., Sakaguchi, SOld, L.J., Kato, T., Shiku, H.
- Journal Title
  
  Int.J.Cancer
  
  Volume: 127 Pages: 759-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Complement drives Th-17 cell differentiation and triggers autoimmune disease.2010
- Author(s)
  Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S.,Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Kohl, J., Heyman, B.,Takahashi, M., Fujita, T., Mimori, T., Sakaguchi, S.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 207 Pages: 1135-43
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Complement drives Th-17 cell differentiation and triggers autoimmune disease.2010
- Author(s)
  Hashimoto, M., Hirota, K., Yoshitomi, H., Maeda, S., Teradaira, S., Akizuki, S., Prieto-Martin, P., Nomura, T., Sakaguchi, N., Kohl, J., Heyman, B., Takahashi, M., Fujita, T., Mimori, T., Sakaguchi, S.
- Journal Title
  
  J.Exp.Med. 207
  
  Pages: 1135-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., and Smyth,M.J.
- Journal Title
  
  Cancer Res
  
  Volume: 70 Pages: 2665-2674
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] FOXP3+ regulatory T cells in the human system.2010
- Author(s)
  Sakaguchi, S., Miyara, M., Costantino, C. M., and Hafler, D. A.
- Journal Title
  
  Nat. Rev. Immunol.
  
  Volume: 185 Pages: 2295-305
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.2010
- Author(s)
  Snell, L. M., McPherson, A. J., Lin, G. H., Sakaguchi, S., Pandolfi, P. P., Riccardi, C., and Watts, T. H.
- Journal Title
  
  J.Immunol.
  
  Volume: 185 Pages: 7223-7234
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Conditional stability of T cells.2010
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Nature
  
  Volume: 468 Pages: 41-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : roles of Tcell erceptor for their development and function.2010
- Author(s)
  Ohkura, N., Sakaguchi, S.
- Journal Title
  
  Semin.Immunopathol.
  
  Volume: 32 Pages: 95-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells: roles of Tcell erceptor for their development and function.2010
- Author(s)
  Ohkura, N., and Sakaguchi, S
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: 32 Pages: 95-106
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] The generation of donor-specific CD4+CD25++CD45RA+ naive regulatory T cells in operationally tolerance patients after pediatric living-donor liver transplantation.2010
- Author(s)
  Nafady-Hego, H., Li, Y., Ohe, H., Zhao, X., Satoda, N., Sakaguchi, S., Wood, K., Uemoto, S., Koshiba, T.
- Journal Title
  
  Transplantation
  
  Volume: 90 Pages: 1547-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulation of Zap 70 expression during thymic development allows temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.2010
- Author(s)
  Saini M, Sinclair C, Marshall D, Tolaini M, Sakaguchi S, Seddon B.
- Journal Title
  
  Science Signaling. 3(114):ra23.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Chronic arthritis leads to disturbances in the bone collagen network.2010
- Author(s)
  Caetano-Lopes J, Nery AM, Canhao H, Duarte J, Cascao R, Rodrigues A, Perpetuo IP, Abdulghani S, Amaral PM, Sakaguchi S, Konttinen YT, Graca L, Vaz MF, Fonseca JE.
- Journal Title
  
  Arthritis Res Ther. 12(1):R9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4+ T Cell Responses Enhances Antiparasitic Immunity.2010
- Author(s)
  Haque A, Stanley AC, Amante FH, Rivera FD, Zhou Y, Kuns RD, Yardley V, Sakaguchi S, Hill GR, Engwerda CR.
- Journal Title
  
  J Immunol. 184
  
  Pages: 2583-2592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.2010
- Author(s)
  Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato,E., Kondo, S., Allison, J. P., Sakaguchi,S., Old, L. J., Kato, T., and Shiku, H.
- Journal Title
  
  Clin. Cancer Res.
  
  Volume: 16 Pages: 2781-91
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxo1 and Foxo3 help Foxp3.2010
- Author(s)
  Ohkura N, Sakaguchi S
- Journal Title
  
  Immunity
  
  Volume: 33 Pages: 835-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.2010
- Author(s)
  Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato, E., Kondo, S., Allison, J.P., Sakaguchi, S.
- Journal Title
  
  Clin.Cancer Res.
  
  Volume: 16 Pages: 2781-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens.2010
- Author(s)
  Cote, A.L., Zhang, P., O'Sullivan, J.A., Jacobs, V.L., Clemis, C.R., Sakaguchi, S., Guevara-Patino, J.A., Turk, M.J.
- Journal Title
  
  J.Immunol
  
  Volume: 186 Pages: 275-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] FOXP3+ regulatory T cells in the human system.2010
- Author(s)
  Sakaguchi, S., Miyara, M., Costantino, C.M., Hafler, D.A.
- Journal Title
  
  Nat.Rev.Immunol.
  
  Volume: 185 Pages: 2295-305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion.2010
- Author(s)
  Teng, M.W., Swann, J.B., von Scheidt B, Sharkey, J., Zerafa, N., McLaughlin, N., Yamaguchi, T., Sakaguchi, S., Darcy, P.K., Smyth, M.J.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 2665-2674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells in tumor immunity2010
- Author(s)
  Nishikawa, H., and Sakaguchi, S
- Journal Title
  
  Int. J. Cancer.
  
  Volume: 127 Pages: 759-67
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance.2009
- Author(s)
  Nagahama, K., Fehervari, Z., Oida, T., Ogawa, 0., Sakaguchi, S.
- Journal Title
  
  Int.Immunol. 21
  
  Pages: 379-391
- NAID
  10025385421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.2009
- Author(s)
  Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
- Journal Title
  
  Proc Natl Acad Sci U S A. 106
  
  Pages: 13974-13949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion.2009
- Author(s)
  Miyara, M., Wing, K., Sakaguchi, S.
- Journal Title
  
  J Allergy Clin Immunol. 123
  
  Pages: 749-755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation.2009
- Author(s)
  Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., and Uemoto, S.
- Journal Title
  
  Transplantation.
  
  Volume: 87 Pages: 606-614
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runx1/Cbf・complexes for in vivo suppressive function of FoxP3+regulatory T cells2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S.
- Journal Title
  
  Immunity.
  
  Volume: 31 Pages: 609-620
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells : how do they suppress immune responses?2009
- Author(s)
  Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T.
- Journal Title
  
  Int. Immunol. 21
  
  Pages: 1105-1111
- NAID
  10027389567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) Tcells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages: 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg2009
- Author(s)
  Sakaguchi, S., Wing, K., and Yamaguchi, T.
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 39 Pages: 2331-6
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance.2009
- Author(s)
  Nagahama, K., Fehervari, Z., Oida, T., Ogawa, O., and Sakaguchi, S.
- Journal Title
  
  Int.Immunol.
  
  Volume: 21 Pages: 379-391
- NAID
  10025385421
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells exert checks and balances on self-tolerance and autoimmunity.2009
- Author(s)
  Wing K, Sakaguchi S.
- Journal Title
  
  Nat. Immunol. 11
  
  Pages: 7-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] A novel modifier of regulatory T cells2009
- Author(s)
  Ohkura, N,. Sakaguchi, S.
- Journal Title
  
  Nat Immunol. 10
  
  Pages: 385-686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-22009
- Author(s)
  Okamura, T., Fujio, K., Shibuya,M., Sumitomo, S., Shoda, H., Sakaguchi,S., and Yamamoto, K.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 106 Pages: 13974-9
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells: how do they suppress immune responses?2009
- Author(s)
  Sakaguchi, S., Wing, K., Onishi,Y.
- Journal Title
  
  Int. Immunol
  
  Volume: 21 Pages: 1105-11
- NAID
  10027389567
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis2009
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchis Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
- Journal Title
  
  Arthritis Rheum. 60
  
  Pages: 2294-2303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Therapeutic Immunity by Adoptive Tumor-primed CD4(+)T-cell Transfer in Combination With In Vivo GITR Ligation.2009
- Author(s)
  Liu, Z., Tian, S., Falo, L.D.Jr, Sakaguchi, S., You, Z.
- Journal Title
  
  Mol Ther. 17
  
  Pages: 1274-1284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] M., Wing, K., and Sakaguchi, S. Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion.2009
- Author(s)
  Miyara, M., Wing, K., and Sakaguchi, S.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 123 Pages: 749-55
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.2009
- Author(s)
  Onodera, T., Jang, M. H., Guo, Z., Yamasaki, M., Hirata, T., Bai, Z., Tsuji,N. M., Nagakubo, D., Yoshie, O., Sakaguchi, S., Takikawa, O., and Miyasaka, M.
- Journal Title
  
  J. Immunol
  
  Volume: 183 Pages: 5608-5614
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Immune rejection of mouse tumors expressing mutated self.2009
- Author(s)
  Duan F, Lin Y, Liu C, Engelhorn ME, Cohen AD, Curran M, Sakaguchi S, Merghoub T, Terzulli S, Wolchok JD, Houghton AN.
- Journal Title
  
  Cancer Res. 69
  
  Pages: 3545-3553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., and Sakaguchi, S.
- Journal Title
  
  Immunity
  
  Volume: 30 Pages: 899-911
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes : functional involvement of the CTLA-4B7 and CCL22/CCR4 interacoons.2009
- Author(s)
  Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M.
- Journal Title
  
  J.Immunol. 183
  
  Pages: 5608-5614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor.2009
- Author(s)
  Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Gorochov, G., Sakaguchi, S.
- Journal Title
  
  Immunity. 30
  
  Pages: 899-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation.2009
- Author(s)
  Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., Uemoto, S.
- Journal Title
  
  Transplantation. 87
  
  Pages: 606-614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of Runxl/Cbf complexes for in vivo suppressive function of FoxP^<3+> regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages: 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours.2009
- Author(s)
  Piao J,Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S, Azuma M.
- Journal Title
  
  Immunity. 127
  
  Pages: 489-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Indispensable role of in vivo suppressive function of FoxP3+ regulatory T cells.2009
- Author(s)
  Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi, Y., Taniuchi, I., Sakaguchi, S.
- Journal Title
  
  Immunity. 31
  
  Pages: 609-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Dynamics of peripheral tolerance and immune regulation mediated by Treg.2009
- Author(s)
  Sakaguchi, S., Wing, K., Yamaguchi, T.
- Journal Title
  
  Eur. J.Immunol. 39
  
  Pages: 2331-2336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 29
  
  Pages: 10113-10118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cell and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., and Ono, M
- Journal Title
  
  Cell 133
  
  Pages: 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Value of FOXP3 Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung Transplantation.2008
- Author(s)
  Satoda, N., Shoji, T., Wu, Y., Fujinaga, T., Chen, F., Aoyama, A., Zhang, J. T., Takahashi, A., Okamoto, T., Matsumoto, I., Sakai, H., Li, Y., Zhao,X., Manabe, T., Kobayashi, E., Sakaguchi, S., Wada, H., Ohe, H., Uemoto, S., Tottori, J., Bando, T., Date
- Journal Title
  
  J. Heart Lung Transplant
  
  Volume: 27 Pages: 1293-1301
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cells and immune tolerance2008
- Author(s)
  Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M.
- Journal Title
  
  Cell
  
  Volume: 133 Pages: 775-787
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 29 Pages: 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+ regulatory T cell function.2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., Sakaguchi, S.
- Journal Title
  
  Science. 322
  
  Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Foxp^<3+> natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation2008
- Author(s)
  Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi. S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 29
  
  Pages: 10113-10118
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] CTLA-4 control over Foxp3+regulatory T cell function2008
- Author(s)
  Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S.
- Journal Title
  
  Science.
  
  Volume: 322 Pages: 271-275
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] The presence of FOXP3 expressing T cells within grafts of tolerance human liver transplant recipients.2008
- Author(s)
  Li, Y., Zhao, X., Cheng, D., Haga, H., Tsuruyama, T., Wood, K., Sakaguchi, S., Tanaka, K., Uemoto, S., and Koshiba, T.
- Journal Title
  
  Transplantation
  
  Volume: 86 Pages: 1837-1843
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Regulatory T cellsin the past and for the future.2008
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  ur. J. Immunol.
  
  Volume: 38 Pages: 901-937
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.2007
- Author(s)
  Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, Iwakura Y, Sakaguchi N, Sakaguchi S.
- Journal Title
  
  J Exp Med. 204
  
  Pages: 41-47
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3 and Aire in thymus-generated T (reg) cells : a link in self-tolerance.2007
- Author(s)
  Nomura T, Sakaguchi S.
- Journal Title
  
  Nat Immunol. 8(4)
  
  Pages: 333-334
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Foxp3 and Aire in thymus-generated T(reg) cells : a link in self-tolerance.2007
- Author(s)
  Nomura T, Sakaguchi S.
- Journal Title
  
  Nat Immunol. 8
  
  Pages: 333-334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3 controls regulatory T cell function via i nteracting with AML1/Runxl..2007
- Author(s)
  Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.
- Journal Title
  
  Nature. 446
  
  Pages: 685-689
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cell-mediated suppression : potential role of ICER..2007
- Author(s)
  Bodor J, Fehervari Z, Diamond B, Sakaguchi S.
- Journal Title
  
  J Leukoc Biol. 81
  
  Pages: 161-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] and pathological aspects of operational tolerance after pediatric living-donor liver transplantation.2007
- Author(s)
  Koshiba T, Li Y, Takemura M, Wu Y, Sakaguchi S, Minato N, Wood KJ, Haga H, Ueda M, Uemoto S. Clinical, immunological
- Journal Title
  
  Transpl Immunol. 17
  
  Pages: 94-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Natural regulatory T cells : mechanisms of suppression.2007
- Author(s)
  Miyara M, Sakaguchi S.
- Journal Title
  
  Trends Mol Med. 13
  
  Pages: 108-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3 controls regulatory T-cell function by interacting with AMLl/Runxl.2007
- Author(s)
  Ono M, Yaguchi H, Ohkura N, (4), Tsukada T, Sakaguchi S.
- Journal Title
  
  Nature 446 (7136)
  
  Pages: 685-689
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] T lymphocytes : Regulatory.2006
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Nature Encyclopedia of Life Sciences. Wiley Interscience
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] van den Brink MR. Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity..2006
- Author(s)
  Ramirez-Montagut T, Chow A, Hirschhom-Cymerman D, Terwey TH, Kochman AA, Lu S, Miles RC, Sakaguchi S, Houghton AN
- Journal Title
  
  J Immunol. 176
  
  Pages: 6434-6442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells : meden agan..2006
- Author(s)
  Sakaguchi, k S.:
- Journal Title
  
  Immunol. Rev 212
  
  Pages: 5-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease.2006
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Curr Top Microbiol Immunol 305
  
  Pages: 51-66
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T cells. In The hereditary Basis of Rheumatic Diseases,.2006
- Author(s)
  Sakaguchi, S et al.
- Journal Title
  
  Progress in Inflammation Research Basel
  
  Pages: 147-159
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Peacekeepers of the immune system.2006
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Sci Am. 259
  
  Pages: 56-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Conversion of alloantigen-specific CD8+ T-cell priming through in vitro ligation of glucocorticoid-induced TNF receptor..2006
- Author(s)
  Kim, J., Choi, W.S, Kim, H.J., Suh, J-H., Sakaguchi, S., Kwon B.
- Journal Title
  
  J. Immunol. 176
  
  Pages: 5223-5231
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction : Part 1.2006
- Author(s)
  Sakaguchi, S., Sakaguchi, N., Yoshitomi, H., Hata, H., Takahashi, T., Nomura, T.
- Journal Title
  
  Semin. Immunol. 18
  
  Pages: 199-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Delineation of immunoregulatory properties of adult T-cell leukemia cells..2006
- Author(s)
  Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T.
- Journal Title
  
  Int. J. Hematol. 84
  
  Pages: 63-69
- NAID
  10020357858
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells : meden agan.2006
- Author(s)
  Sakaguchi. S.
- Journal Title
  
  Immunol. Rev. 212
  
  Pages: 5-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] A role for Dicer in immune regulation.2006
- Author(s)
  Cobb BS, Hertweck A, Smith J, O'connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M.
- Journal Title
  
  J Exp Med. 203
  
  Pages: 2519-2527
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3^+CD25^+CD4^+ natural regulatory T cells in dominant self-tolerance and autoimmune disease.2006
- Author(s)
  Sakaguchi, S.et ai
- Journal Title
  
  Immunol. Rev 212
  
  Pages: 8-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in allergy. 6 : 482-8, 2006.2006
- Author(s)
  Wing, K., Sakaguchi, S.
- Journal Title
  
  Cum Opin. Allergy and Immunol. 55
  
  Pages: 335-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing naturally arising CD4+ regulatory T cells..2006
- Author(s)
  Ono, M., Shimizu, J., Miyachi, Y., Sakaguchi, S.
- Journal Title
  
  J. Immunol. 176
  
  Pages: 4748-4756
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] The dichotomous roles of IL-2 : tolerance versus immunity.2006
- Author(s)
  Fehervari, Z., Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Trends Immunol. 27
  
  Pages: 109-111
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Skin controls immune regulators.2006
- Author(s)
  Yamaguchi T, Sakaguchi S
- Journal Title
  
  Nat Med 12
  
  Pages: 1358-1359
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Introduction : Regulatory T cells2006
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Springer Ssemin. Immunopathol 28
  
  Pages: 1-2
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3-dependent and-independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis..2006
- Author(s)
  Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., Sakaguchi.S.
- Journal Title
  
  Mt. Immunol. 18
  
  Pages: 1197-1209
- NAID
  10018772951
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preparation of regulatory T cells in vitro, In Immunological Tolerance2006
- Author(s)
  Nagahama, K, Sakaguchi, S
- Journal Title
  
  Methods and Protocols, edit. P. J. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Emerging possibilities in the development and function of regulatory T cells.2006
- Author(s)
  Wing, K., Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Int. Immunol. 18
  
  Pages: 991-1000
- NAID
  10020617443
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+ T cells..2006
- Author(s)
  Lee SK, Choi BK, Kim YH, Kang WJ, Kim KH, Sakaguchi S, Suh JH, Kim TY, Kwon BS.
- Journal Title
  
  Immunology. 119(4)
  
  Pages: 479-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] 「研究成果報告書概要(欧文)」より2006
- Author(s)
  Sakaguchi, S., Takahashi, T., Hata, H., Yoshitomi, H., Tanaka, S., Hirota, K.
- Journal Title
  
  Birkhaeuser Verlag, Basel
  
  Pages: 147-159
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction : Part 1.2006
- Author(s)
  Sakaguchi, S et al.
- Journal Title
  
  Semin. Immunol, 18
  
  Pages: 199-206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity..2006
- Author(s)
  Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4904-4912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease..2006
- Author(s)
  Sakaguchi, S., Ono, M., Setoguchi, R., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., Nomura, T.
- Journal Title
  
  Immunol. Rev. 212
  
  Pages: 8-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in immune surveillance and treatment of cancer. Semin..2006
- Author(s)
  Yamaguchi, T., Sakaguchi, S.
- Journal Title
  
  Cancer Biol. 16
  
  Pages: 115-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25^+Cd4^+ regulatory T cells in self-tolerance and autoimmune disease.2006
- Author(s)
  Sakaguchi, S., et al.
- Journal Title
  
  Curr Top Microbiol Immunol. 305
  
  Pages: 51-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD4+CD25+ Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice..2006
- Author(s)
  Nishioka, T., Shimizu, J, Iida, R., Yamazaki, S., Sakaguchi, S.
- Journal Title
  
  J. Immunol. 176
  
  Pages: 6586-6593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+ -ATPase-Reactive TCR Transgenic Mouse..2006
- Author(s)
  Katakai T, Nomura T, Gonda H, Sugai M, Agata Y, Nishio A, Masuda T, Sakaguchi S, Shimizu A.
- Journal Title
  
  Jlmmunol. 177
  
  Pages: 7858-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Cutting Edge : Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism..2005
- Author(s)
  Gondek, D.C., Lu, L-F., Quezada, S.A., Sakaguchi, S., Noelle, R.J.
- Journal Title
  
  J. Immunol. 174
  
  Pages: 1783-1786
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Animal models of arthritis caused by systemic alteration of the immune system.2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N.
- Journal Title
  
  Curr Opin Immunol. 17
  
  Pages: 589-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.2005
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Nat. Immunol. 6
  
  Pages: 345-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Definition of target antigens for naturally occurring CD4+CD25+ regulatory T cells.2005
- Author(s)
  Nishikawa, H., Kato, T., Tawara, I., Saito, K., Ikeda, H., Kuribayashi, K., Allen, P.M., Schreiber, R.D., Sakaguchi, S., Old, L.J., Shiku, H.
- Journal Title
  
  J. Exp. Med. 201
  
  Pages: 681-686
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice..2005
- Author(s)
  Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, Bando Y, Izumi K, Takahashi T, Nomura T, Sakaguchi S, Ueno T, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matsushima A, Yamada G, Matsumoto M.
- Journal Title
  
  J. Immunol. 174
  
  Pages: 1862-1870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD4+ regulatory cells as a potential immunotherapy. Philos Trans R Soc Lond B2005
- Author(s)
  Fehervari Z, Sakaguchi S.
- Journal Title
  
  Biol Sci. 360
  
  Pages: 1647-1661
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] History of CD25+CD4+ regulatory T cells. In Regulatory T cells in inflammation, Progress in Inflammation Research. Eds. L. S. Taams, A. N. Akbar, and M. H. M. Wauben,.2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N.
- Journal Title
  
  Birkhaeuser Verlag, Basel
  
  Pages: 3-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in immunologic self-tolerance and autoimmune diseases..2005
- Author(s)
  Sakaguchi.S., Sakaguchi, N.
- Journal Title
  
  Int. Rev. Immunol. 24
  
  Pages: 211-226
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preface : Regulatory T cells in autoimmune diseases2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Int.Rev.Immunol (印刷中)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in tumor immunity.2005
- Author(s)
  Nomura, T., Sakaguchi, S.
- Journal Title
  
  Curr Top Microbiol Immunol. 293
  
  Pages: 287-302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells.2005
- Author(s)
  Fehervari, Z., Sakaguchi, S
- Journal Title
  
  Measuring Immunity, (In eds. Elsevier.)
  
  Pages: 322-335
- NAID
  40022339907
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in self-tolerance and autoimmune diseases2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Int.Rev.Immunol (印刷中)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in immunologic self-tolerance and autoimmune diseases.2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N
- Journal Title
  
  Int. Rev. Immunol 24
  
  Pages: 211-226
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] History of CD25^+CD4^+ regulatory T cells. In Regulatory T cells in inflammation,.2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N
- Journal Title
  
  Progress in Inflammation Research Basel
  
  Pages: 3-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25^+CD4^+regulatory T cells in immunologic tolerance to self and non-self2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Nature Immunol 6
  
  Pages: 345-352
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation.2005
- Author(s)
  Yoshizawa, A., Ito, A., Li, Y., Koshiba, T., Sakaguchi, S., Wood, K.J., Tanaka, K.
- Journal Title
  
  Transplant. Proc. 37
  
  Pages: 37-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Animal models of arthritis caused by systemic alteration of the immune system.2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Curr Opin Immunol. 17
  
  Pages: 589-594
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Noelle RJ : Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance : the interplay of clonal anergy and immune regulation..2005
- Author(s)
  Quezada SA, Bennett K, Blazar BR, Rudensky AY, Sakaguchi S
- Journal Title
  
  J. Immunol. 175
  
  Pages: 771-779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Autoimmunity..2005
- Author(s)
  Bach, J.F., Sakaguchi, S.
- Journal Title
  
  Curr Opin Immunol 17
  
  Pages: 567-569
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Phenotypic and functional relationship between adult T cell leukemia and regulatory T cells..2005
- Author(s)
  Matsubara, Y., Hori, T., Morita, R., Sakaguchi, S., Uchiyama, T.
- Journal Title
  
  Leukemia 19
  
  Pages: 482-483
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in tumor immunity..2005
- Author(s)
  Nomura, T., Sakaguchi, S
- Journal Title
  
  Curr Top Microbiol Immunol 293
  
  Pages: 287-302
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells..2005
- Author(s)
  Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., Sakaguchi, S.
- Journal Title
  
  J. Exp. Med. 202
  
  Pages: 885-891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Animal models of arthritis caused by systemic alteration of the immune system..2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N.
- Journal Title
  
  Curr Opin Immunol 17
  
  Pages: 589-594
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preface : Regulatory T cells in autoimmune diseases.2005
- Author(s)
  Sakaguchi, S., Sakaguchi, N.
- Journal Title
  
  Preface : Regulatory T cells in autoimmune diseases. 24
  
  Pages: 211-226
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.2005
- Author(s)
  Setoguchi, R., Hori, S., Takahashi, T., Sakaguchi, S.
- Journal Title
  
  J. Exp. Med. 201
  
  Pages: 723-735
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preface : Regulatory T cells in autoimmune diseases..2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Int. Rev. Immunol 24
  
  Pages: 157-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.2005
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Nat.Immunol. 6
  
  Pages: 345-352
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells. In Measuring Immunity2005
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Thompson, Elsevier.
  
  Pages: 322-335
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Environmental stimulation of innate immunity triggers chronic arthritis in mice genetically prone to produce arthritogenic autoimmune T cells : a key role of fungal 13-glucans and their receptor Dectin-12005
- Author(s)
  Yoshitomi, H., Sakaguchi, N., Brown, G., Tagami, T., Sakihama, T., Nomura, T., Akira, S., Gordon, S., Nakamura, T., Sakaguchi, S.
- Journal Title
  
  J. Exp. Med. 201
  
  Pages: 949-960
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD4^+ regulatory cells as a potential immunotherapy.2005
- Author(s)
  Fehervari Z, Sakaguchi S
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci 360
  
  Pages: 1647-1661
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising Foxp3-expressing CD25^+CD4^+ regulatory T cells in immunological tolerance to self and non-self.2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Nat. Immunol 6
  
  Pages: 345-352
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] History of CD25^+CD4^+ regulatory T cells2005
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Progress in Inflammation Research (印刷中)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] History of CD25+CD4+ regulatory T cells. In Regulatory T cells in inflammation, Progress in Inflammation Research.2005
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Progress in Inflammation Research. (Eds.L.S.Taams, A.N.Akbar, and M.H.M.Wauben, Birkhaeuser Verlag, Basel)
  
  Pages: 3-17
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] derived from naive CD4+CD25-T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance..2005
- Author(s)
  Chai, J-G, Xue, S., Coe, D., Addey, C., Bartok, I., Scott, D., Simpson, E., Stauss, H.J., Hori, S., Sakaguchi, S., Dyson, J.P.Regulatory T cells
- Journal Title
  
  Transplantation. 79
  
  Pages: 1310-1316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preface : Regulatory T cells in autoimmune diseases.2005
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Int. Rev. Immunol. 24
  
  Pages: 157-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Development and function of CD25^+CD4^+ regulatory T cells.2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Curr Opin Immunol. 16
  
  Pages: 203-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.2004
- Author(s)
  Zhang, X., Koldzix, D.J., Izikson, L., Reddy, J., Nazareno, R.F., Sakaguchi, S., Kuchroo, V.K., Weiner, H.L.
- Journal Title
  
  Int. Immunology. 16
  
  Pages: 1-8
- NAID
  10013083385
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] A crucial role of IL-2 in the homeostatic maintenance of CD25+CD4+ regulatory T cells.2004
- Author(s)
  Setoguchi, R., Hori, S., Takahashi, T., Sakaguchi, S.
- Journal Title
  
  mmunology2004. MedimondI S.r.1., Bologna, Italy.
  
  Pages: 341-344
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Distinct contribution of IL-6, TNF-a, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice..2004
- Author(s)
  Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Rennick, D., Azuma, Y., Kanai, C., Moriizumi, E., Nakamura, T., Sakaguchi, S.
- Journal Title
  
  J. Clin. Invest. 114
  
  Pages: 582-588
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells..2004
- Author(s)
  Yagi, H., Nomura, T, Nakamura, K., Kitawaki, T., Hori, S., Maeda, M., Onodera, M, Uchiyama, T, Fujii, S., Sakaguchi, S.
- Journal Title
  
  Int. Immunol. 16
  
  Pages: 1643-1656
- NAID
  10013778181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in tumor immunity. In Cancer Immunotherapy, edit. K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi.2004
- Author(s)
  Sakaguchi, S., Ko, K., Yamazaki, S., Nakamura, K., Hirota, K., Nomura, T.
- Journal Title
  
  Princess Takamatsu Cancer Research Fund, Tokyo
  
  Pages: 47-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Altered thymic T-cell selection due to a spontaneous mutation of the ZAP-70 gene causes autoimmune arthritis.2004
- Author(s)
  Sakaguchi, N
- Journal Title
  
  Immunology 2004
  
  Pages: 239-242
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells..2004
- Author(s)
  Choi, B.K., Bae, J.S., Choi, E.M., Kang, W.J., Sakaguchi, S., Vinay, D.S., won, B.S.
- Journal Title
  
  J. Leukoc. Biol. 75
  
  Pages: 785-791
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD25+CD4+ T cells in human cord blood : an immunoregulatory subset with na・e phenotype and specific expression of forkhead box p3 (Foxp3) gene..2004
- Author(s)
  Takahata, Y., Nomura, A., Takada, H., Ohga, S., Furuno, K., Hikino, S., Nakayama, H., Sakaguchi, S., Hara, T.
- Journal Title
  
  Exp Hematol. 32
  
  Pages: 622-629
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] NF-kB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner.2004
- Author(s)
  Kajiura, F., S.Sun, T Nomura, K.Izumi, T.Ueno, Y.Bando, N.Kuroda, H.Han, Yi Li, A.Matsushima, Y.Takahama, S.Sakaguchi, T.Mitani, M.Matsumoto.
- Journal Title
  
  J. Immunol. 172
  
  Pages: 2067-2075
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3, a critical regulator of regulatory T cell development and function.. 6 : 745-51, 2004.2004
- Author(s)
  Hori, S., Sakaguchi, S
- Journal Title
  
  Microbes Infect 6
  
  Pages: 745-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising CD25+CD4+ regulatory T cells..2004
- Author(s)
  Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka.K., Sakaguchi, S.
- Journal Title
  
  Int. Immunol. 16
  
  Pages: 1189-1201
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of CD25アCD4+ regulatory T cell activation and function by dendritic cells..2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Int. Immunol. 16
  
  Pages: 1769-1780
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising CD4^+ regulatory T cells for immunologic self-tolerance and negative control of immune responses.2004
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Annu. Rev. Immunol. 22
  
  Pages: 531-562
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in tumor immunity. In Cancer Immunotherapy, edit. K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi.,2004
- Author(s)
  Sakaguchi, S et al.
- Journal Title
  
  Princess Takamatsu Cancer Research Fund
  
  Pages: 47-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation..2004
- Author(s)
  Li, Y., Koshiba, T., Yoshizawa, A., Yonekawa, Y., Ito, A., Mori, T., Kawamoto, H., Tanaka, Y., Sakaguchi, S., Minato, N., Wood, K.J., Tanaka, K
- Journal Title
  
  Am J. Transplant. 4
  
  Pages: 2118-2125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection..2004
- Author(s)
  He, H., Messer, R.J., Sakaguchi, S., Yang, G., Robertson, S.J., Hasenkrug, K.J.
- Journal Title
  
  J. Virology 78
  
  Pages: 11641-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Altered thymic T-cell selection due to a spontaneous mutation of the ZAP-70 gene causes auto immune arthritis..2004
- Author(s)
  Sakihama, T., Negishi, I., Nakatsuru, S., Sakaguchi, S.
- Pages
  239-242
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] A paragon of self-tolerance : Regulatory T cells and the control of immune responses..2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Arthritis Res. Ther 6
  
  Pages: 19-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Development and function of CD25+CD4+ regulatory T cells..2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Curr Opin Immunol. 16
  
  Pages: 203-208
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] GITR Activation induces an opposite effect on alloreactive CD4+ and CD8+ T cells in graft-versus-host disease..2004
- Author(s)
  Muriglan, S.J., Ramirez-Montagut, T., Alpdogan, 0., Van Huystee, T.W., Eng, J.M., Hubbard, V.M., Kochman, A.A., Tjoe, K.H., Riccardi, C., Pandolfi, P.P., Sakaguchi, S., Houghton, A.N., Van Den Brink, M.R.
- Journal Title
  
  J. Exp. Med 200
  
  Pages: 149-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection..2004
- Author(s)
  Dittmer, U., He, H., Messer, R.J., Schimmer, S., Olbrich, A.R., Ohlen, C., Greenberg, P.D., Stromnes, I.M., Iwashiro, M., Sakaguchi, S., Evans, L.H., Peterson, K.E., Yang, G, Hasenlcrug, K.J.
- Journal Title
  
  Immunity. 20
  
  Pages: 1-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of CD25^+CD4^+ regulatory T cell activation and function by dendritic cells.2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Int. Immunol. 16
  
  Pages: 1769-1780
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Induction of fatal auto immune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing T cells..2004
- Author(s)
  Ono, M., Shimizu, J., Miyachi, Y., Sakaguchi, S.
- Journal Title
  
  Immunology 2004. Medimond S.r.l., Bologna, Italy.
  
  Pages: 193-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Altered thymic T-cell selection due to a spontaneous mutation of the ZAP-70 gene causes autoimmune arthritis.2004
- Author(s)
  Sakaguchi, N., et al.
- Journal Title
  
  Immunology 2004
  
  Pages: 239-242
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells.2004
- Author(s)
  Kanamaru, F., Youngnak, P., Hashiguchi, M., Nishioka, T., Takahashi, T., Sakaguchi.S., Ishikawa, I., Azuma, M.
- Journal Title
  
  J. Immunol. 172
  
  Pages: 7306-7314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses.2004
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Annu. Rev. Immunol. 22
  
  Pages: 531-562
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising CD4^+ regulatory T cells for immunologic self-tolerance and negative control of immune responses.2004
- Author(s)
  Sakaguchi, S
- Journal Title
  
  Ann.Rev.Immunol. 22
  
  Pages: 531-562
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Costimulation via glucocorticoid-induced tumor necrosis factor receptor (GITR) in both conventional and CD25^+ regulatory CD4^+ T cells.2004
- Author(s)
  Kanamaru F, Youngnak P, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M.
- Journal Title
  
  J. Immunol 172
  
  Pages: 7306-7314
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] A paragon of self-tolerance : Regulatory T cells and the control of immune responses.2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Arthritis Res. Ther 6
  
  Pages: 19-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD4^+ regulatory T cells and immune control.2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  J. Clin. Invest. 114
  
  Pages: 1209-117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Italy.2004
- Author(s)
  Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S.
- Journal Title
  
  Immunology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulation of autoimmune diabetes by non-islet-specific T cells-a role for the glucocorticoid-induced TNF receptor.2004
- Author(s)
  Suri, A., Shimizu, J., Katz, J.D., Sakaguchi, S., Unanue, E.R., Kanagawa, 0.
- Journal Title
  
  Eur. J. Immunol. 34
  
  Pages: 447-454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Foxp3, a critical regulator of regulatory T cell2004
- Author(s)
  Hori, S., Sakaguchi, S.
- Journal Title
  
  Microbes Infect. 6
  
  Pages: 745-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] CD4+ regulatory T cells and immune control.2004
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  J. Clin. Invest. 114
  
  Pages: 1209-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] The origin of FOXP3-expressing CD4^+ regulatory T cells : thymus or periphery2003
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  J. Clin. Invest 112
  
  Pages: 1310-1312
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in transplantation.2003
- Author(s)
  Wood, K., Sakaguchi, S
- Journal Title
  
  Nat. Rev. Immunol. 3
  
  Pages: 199-210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of immune responses by naturally arising CD4^+ regulatory T cells.2003
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  J. Exp. Med 197
  
  Pages: 397-401
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] The role of regulatory T cells in controlling immunologic self-tolerance..2003
- Author(s)
  Takahashi, T., Sakaguchi, S.
- Journal Title
  
  Int. Rev. Cytol. 225
  
  Pages: 1-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising CD25^+CD4^+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease.2003
- Author(s)
  Takahashi, T., Sakaguchi, S
- Journal Title
  
  Curr. Mol. Med. 3
  
  Pages: 693-706
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Taming transplantation by regulatory T cells.2003
- Author(s)
  Sakaguchi, S.:
- Journal Title
  
  Nat Med 9
  
  Pages: 1117-1118
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of regulatory T cell development by the transcription factor Foxp3.2003
- Author(s)
  Hori, S., Nomura, T., Sakaguchi, S.
- Journal Title
  
  Science. 299
  
  Pages: 1057-1061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of regulatory T cell development by the transcription factor Foxp3.2003
- Author(s)
  Hori, S., Nomura, T., Sakaguchi S.
- Journal Title
  
  Science 299
  
  Pages: 1057-1061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells : mediating compromises between host and parasite...2003
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Nat Immunol 4
  
  Pages: 10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Thymic generation and selection of CD25^+CD4^+ regulatory T cells : Implications of their broad repertoire and high self-reactivity for the maintenance of immunologic self-tolerance2003
- Author(s)
  Sakaguchi, S. et al.
- Journal Title
  
  Novartis Foundation Symposium 252
  
  Pages: 6-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Taming transplantation by regulatory T cells.2003
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Nat Med. 9
  
  Pages: 1117-1118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of autoimunity by natural regulatory T cells..2003
- Author(s)
  Hori, S., Takahashi, T., Sakaguchi, S.
- Journal Title
  
  Adv. Immunol. 81
  
  Pages: 329-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.2003
- Author(s)
  Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N.
- Journal Title
  
  J. Autoimmunity 20
  
  Pages: 291-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of immune responses by naturally arising CD4+ regulatory T cells..2003
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  J. Exp. Med. 197
  
  Pages: 397-401
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Control of autoimunity by natural regulatory T cells.2003
- Author(s)
  Hori, S., Takahashi, T., Sakaguchi, S
- Journal Title
  
  Adv. Immunol. 81
  
  Pages: 329-369
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in transplantation.2003
- Author(s)
  Wood, K.J., H.Ushigome, M.Karim, A.Bushell, H.S, S.Sakaguchi.
- Journal Title
  
  Novartis Foundation Symposium.Am. J. Pharmacogenomics 252 28:177-88 discussion
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulatory T cells in transplantation.2003
- Author(s)
  Wood, K., Sakaguchi, S.
- Journal Title
  
  Nat. Rev. Immunol 3
  
  Pages: 199-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] mediating compromises between host and parasite.2003
- Author(s)
  Sakaguchi, S.Regulatory T cells
- Journal Title
  
  Nat Immunol. 4
  
  Pages: 10-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice2003
- Author(s)
  Sakaguchi, N. et al.
- Journal Title
  
  Nature 426
  
  Pages: 454-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease..2003
- Author(s)
  Takahashi, T., Sakaguchi, S.
- Journal Title
  
  Curr. Mol. Med. 3
  
  Pages: 693-706
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Thymic generation and selection of CD25+CD4+ regulatory T cells : Implications of their broad repertoire and high self-reactivity for the maintenance of immunologic self-tolerance..2003
- Author(s)
  Sakaguchi, S., Hori, S., Fukui, Y., Sasazuki, T., Sakaguchi, N., Takahashi, T.
- Journal Title
  
  Novartis Foundation Symposium. 252 252
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] The role of regulatory T cells in controlling immunologic self-tolerance.2003
- Author(s)
  Takahashi, T., Sakaguchi, S
- Journal Title
  
  Int. Rev. Cytol 225
  
  Pages: 1-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.2003
- Author(s)
  Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T., Tagami, T., Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I., Nakatsuru, S., Sakaguchi, S.
- Journal Title
  
  Nature. 426
  
  Pages: 454-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulation of tumor immunity by CD25^+ Tcells2002
- Author(s)
  Gallimore, A., Sakaguchi, S.
- Journal Title
  
  Immunology 107
  
  Pages: 5-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Immunologic tolerance maintained by regulatory T cells : Implications for autoimmunity, tumor immunity and transplantation tolerance.2002
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Vox Sang 83
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Stimulation of CD25^+ CD4^+ regulatory T cells through GITR breaks immunological self-tolerance.2002
- Author(s)
  Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S.
- Journal Title
  
  Nat Immunol. 3
  
  Pages: 135-142
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Regulation of tumor immunity by CD25+ Tcells.2002
- Author(s)
  Gallimore, A., Sakaguchi, S.
- Journal Title
  
  Immunology 107
  
  Pages: 5-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Stimulation of CD25+ CD4+ regulatory T cells through GITR breaks immunological self-tolerance.2002
- Author(s)
  Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S.
- Journal Title
  
  Nat Immunol. 3
  
  Pages: 135-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Immunologic tolerance maintained by regulatory T cells: Implications for autoimmunity, tumor immunity and transplantation tolerance.2002
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Vox Sang 83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Construction of self-recognizing regulatory T cells from conventional T cells by controllingCTLA-4 and IL-2 expression.
- Author(s)
  Yamaguchi T, Kishi A, Osaki M, Morikawa H, Prieto-Martin P, Wing K, Saito T, and Sakaguchi S.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: (In press)
- Data Source
  KAKENHI-PROJECT-20002007
[Journal Article] Preparation of regulatory T cells in vitro. In Immunological Tolerance : Methods and Protocols, edit. P. J. Fairchild,.
- Author(s)
  Nagahama, K., Sakaguchi, S.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction.
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Semin.Immunol (In press)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T cells.
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Progress in Inflammation Research. (In press)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] a monogenic model of autoimmune arthritis due to altered signal transduction in T cells. In The hereditary Basis of Rheumatic Diseases, Progress in Inflammation Research. Edited by Rikard Holmdahl,.
- Author(s)
  Nomura, T., Sakaguchi, N.SKG mice
- Journal Title
  
  Humana Press (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Introduction : Regulatory T cells. 2006
- Author(s)
  Sakaguchi, S.
- Journal Title
  
  Springer Semin. Immunopathol. 28
  
  Pages: 1-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] T lymphocytes : Regulatory.
- Author(s)
  Fehervari, Z., Sakaguchi, S.
- Journal Title
  
  Nature Encyclopedia of Life Sciences. (In press)
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Naturally arising 305 : 51-66, 2006. Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease.
- Author(s)
  Sakaguchi, S., Setoguchi, R., Yagi, H., Nomura, T.
- Journal Title
  
  Curr Top Microbiol Immunol.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis.
- Author(s)
  Kobayashi K, Suda T, Nan-Ya K, Sakaguchi N, Sakaguchi S, Mild I.
- Journal Title
  
  Inflamm Res. 55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Patent] 制御性T細胞の作製法2018
- Inventor(s)
  坂口　志文、三上　統久
- Industrial Property Rights Holder
  坂口　志文、三上　統久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-155507
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H06295
[Patent] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤2008
- Inventor(s)
  坂口志文
- Industrial Property Rights Holder
  坂口志文
- Filing Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-20002007
[Patent] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤2008
- Inventor(s)
  坂口志文
- Industrial Property Rights Holder
  坂口志文
- Acquisition Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-20002007
[Patent] 4型葉酸受容体も発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤2008
- Inventor(s)
  坂口志文
- Industrial Property Rights Holder
  坂口志文
- Filing Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-20002007
[Patent] 4型葉酸受容体の発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤2005
- Inventor(s)
  坂口志文, 山口智之, 廣田圭司
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2005-134279
- Filing Date
  2005-05-02
- Data Source
  KAKENHI-PROJECT-13140203
[Patent] 免疫抑制性のマクロライド系抗生剤を用いる制御性T細胞の製造方法2005
- Inventor(s)
  坂口志文, 小柴貴明, 伊藤淳, 田中紘一
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2005-289224
- Filing Date
  2005-09-30
- Data Source
  KAKENHI-PROJECT-13140203
[Patent] 抗体の作製方法2005
- Inventor(s)
  坂口志文, 浜窪隆雄, 先浜俊子, 舟橋真一, 岩成宏子
- Industrial Property Rights Holder
  国立大学法人京都大学, 国立大学法人東京大学, 中外製薬株式会社, 株式会社ペルセウスプロテオミクス
- Industrial Property Number
  2005-166547
- Filing Date
  2005-06-07
- Data Source
  KAKENHI-PROJECT-13140203
[Patent] 制御性T細胞の製造方法2005
- Inventor(s)
  坂口志文, 小柴貴明, 伊藤淳, 田中紘一
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2005-106887
- Filing Date
  2005-04-01
- Data Source
  KAKENHI-PROJECT-13140203
[Patent] METHOD FOR DETECING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR4 AS INDECATOR, METHOD FOR TREATING DISEASE2005
- Inventor(s)
  坂口志文, 山口智之, 廣田圭司
- Industrial Property Rights Holder
  KYOTO UNIVERSITY, RIKEN
- Filing Date
  2005-10-03
- Data Source
  KAKENHI-PROJECT-13140203
[Presentation] Discovery of T-Regulatory Cells and Their Role in The Immune System2021
- Author(s)
  Shimon Sakaguchi
- Organizer
  UCL Immunology Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Treg-specific epigenetic variations and susceptibility to common autoimmune diseases2021
- Author(s)
  Shimon Sakaguchi
- Organizer
  Immunogenomics of Disease: Accelerating to Patient Benefit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] 制御性T細胞による免疫応答制御2020
- Author(s)
  坂口志文
- Organizer
  第27回大阪小児感染免疫カンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Control of immune responses by regulatory T cells2020
- Author(s)
  Shimon Sakaguchi
- Organizer
  Robert Koch Lecture
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Molecular targeting of Treg cells for controlling immune responses2020
- Author(s)
  Shimon Sakaguchi
- Organizer
  JSA/WAO Joint Congress 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Molecular targeting of regulatory T cells for treatment of immunological diseases.2020
- Author(s)
  Shimon Sakaguchi
- Organizer
  FOCIS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Basic aspects of Treg biology related to self-tolerance and autoimmune disease, and Treg-based therapeutic approach to autoimmune diseases2020
- Author(s)
  Shimon Sakaguchi
- Organizer
  Rheuma Tolerance for Cure Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Single-cell transcriptomic atlas of thymic Treg development2019
- Author(s)
  Yoshiaki Yasumizu, Naganari Ohkura, Yamami Nakamura, Atsushi Tanaka, Shimon Sakaguchi
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] High dimensional analysis of T-follicular regulatory cells.2018
- Author(s)
  James B Wing, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  Keystone symposia: B Cell-T Cell Interactions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] T-follicuiar regulatory cells in human blood.2018
- Author(s)
  James B Wing, Shimon Sakaguchi
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Distinct transcriptional regulation in tumor-infiltrating regulatory T cells.2018
- Author(s)
  Yujiro Kidani, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  The 8th NIF Winter School on Advanced Immunology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] A role of Ripk3 and Gsdmd in the development of autoimmune arthritis in SKG mice2018
- Author(s)
  Yusuke Takeuchi, Hitomi Watanabe, Gen Kondo, Noriko Sakaguchi, Shimon Sakaguchi, Tsuneyo Mimori,Keiji Hirota:
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Distinct transcriptional regulation in tumor-infiltrating regulatory T cells.2018
- Author(s)
  Yujiro KIdani, YohkoKitagawa, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] A new feature of regulatory Tcells in human head and neck cancer.2018
- Author(s)
  Takuma Matoba, Masaki Imai, Naganari Ohkura, Daisuke Kawakita, Kei Ijichi, Tatsuya Toyama, Akimichi Morita, Shingo Murakami, Shimon Sakagichi, Sayuri Yamazaki
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Satb1-mediated regulation of GM-CSF and PD-1 in effector Th17 cells in experimental autoimmune encephalomyelitis2018
- Author(s)
  Keiko Yasuda, Yohko Kitagawa, Ryoji Kawakami, Hitomi Watanabe, Gen Kondo, Terumi Kohwi-Shigematsu, Shimon Sakaguchi
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] EPIGENETIC LANDSCAPE OF FOXP3 ENHANCER SITES DURING THYMIC FOXP3+ TREG DEVELOPMENT OF CNS0-AND CNS3-DEFICIENT MICE2018
- Author(s)
  R. Kawakami, Y. Kitagawa, K. Hirota, H. Watanabe, G. Kondo, K. Chen, N. Ohkura, S. Sakaguchi
- Organizer
  the 6th Annual Meeting of the International Cytokine & Interferon Society (Cytokines 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin.2018
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka,Hiroaki Shime,Hiroaki Henmi, Masaki Imai,Tsuneyasu Kaisho, Naganari Ohkura Shimon Sakaguchi, Akimichi Morita
- Organizer
  The 47th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Epigenomic signatures of extrathymic-derived regulatory T-cells2017
- Author(s)
  Ryoji Kawakami, Norihisa Mikami, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  第46回日本免疫学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Significance of the regulatory T cell-specific epigenetics in autoimmune disease susceptibility2017
- Author(s)
  Yoshiaki Yasumizu, Naganari Ohkura, Yohko Kitagawa, Shimon Sakaguchi
- Organizer
  第46回日本免疫学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Satb1 controls the differentiation and terminal effector function of Th17 cells2017
- Author(s)
  Keiko Yasuda, Yohko Kitagawa, Shimon Sakaguchi
- Organizer
  第46回日本免疫学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Selective control of regulatory T cells through TCR signaling molecule.2016
- Author(s)
  田中淳、西川博嘉、野口晋佐、高橋直人、坂口教子、坂口志文
- Organizer
  Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Regulatory T cell precursors develop from negative selected CCR7+ Helios+ medullary thymocytes.2016
- Author(s)
  Daniel Y. Hu, Stephen R. Daley, Christopher C. Goodnow, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Epigenetic control of regulatory T cell identity and its assortiation with autoimmune diseases in human.2016
- Author(s)
  Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Soluble form of CTLA-4 produced by regulatory T cells facilitates M2 macrophage differentiation in auto-inflammatory condition.2016
- Author(s)
  Motonao Osaki, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] A distinct subset of CD25 negative T-follicular regulatory cells localizes in the germinal centers2016
- Author(s)
  James Badger Wing, Hannah Hume, Michela Locci, Yohko Kitagawa, Christopher Tay, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] SKGマウスの関節炎に関わるILCsサブセット2016
- Author(s)
  廣田圭司、伊藤能永、近藤玄、田中淳、坂口教子、坂口志文
- Organizer
  Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Specific transcriptional regulation of tumor infiltrating regulatory T cells.2016
- Author(s)
  Yujiro Kidani, Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Role of CTLA-4 in controlling expression of costimulatory molecules by antigen-presenting cells.2016
- Author(s)
  Murat Tekguc, James Badger Wing, Motonao Osaki, Shimon Sakaguchi
- Organizer
  第４５回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16H06295
[Presentation] Regulation of immune responses by sCTLA-4 produced by Treg cells2015
- Author(s)
  Osaki Motonao, Sakaguchi Shimon
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Specific characteristics of tumor infiltrating regulatory T cells2015
- Author(s)
  Kidani Yujiro, Sakaguchi Shimon, Ohkura Naganari
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Rheumatoid arthritis patients-derived gut microbiota induce Th17-mediated arthritis in SKG Mice2015
- Author(s)
  Maeda Yuichi, Umemoto Eiji, Matsushita Masato, Saeki Yukihiko, Ito Yoshinaga, Hirota Keiji, Sakaguchi Noriko, Kumanogo Atushi, Sakaguchi Shimon, Takeda Kiyoshi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Role of glucocorticoid-induced TNFR-related protein (GITR) ligand in effector function and Treg-mediated suppression2015
- Author(s)
  Yasuda Keiko, Nishioka Tomohisa, Hirota Keiji, Takeda Kiyoshi, Akira Shizuo, Sakaguchi Shimon
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Establishment of regulatory T cell-specific super-enhancers2015
- Author(s)
  Kitagawa Yohko, Ohkura Naganari, Sakaguchi Shimon
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of immune responses by regulatory T cells2014
- Author(s)
  Shimon Sakaguchi
- Organizer
  BK seminar Integrative Biosciences and Biotechnology
- Place of Presentation
  Pohan（Korea）
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Regulatory T cells in autoimmunity and tumor immunity2014
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 1st joint symposium of Karolinska Institute and Osaka University 2014 Immunology and Infection biology
- Place of Presentation
  Stockholm（Sweden）
- Year and Date
  2014-06-10
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Genetic and epigenetic basis of Treg cell development and function.2014
- Author(s)
  Shimon Sakaguchi
- Organizer
  2014 Beijing-Shanghai Immunology Joint Symposium
- Place of Presentation
  Hangzhou（China）
- Year and Date
  2014-04-12
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御2014
- Author(s)
  坂口志文
- Organizer
  第38回日本リンパ学会総会東京
- Place of Presentation
  北里大学白金キャンパス薬学部コンベンションホール（東京）
- Year and Date
  2014-06-21
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Regulatory T cells2014
- Author(s)
  Shimon Sakaguchi
- Organizer
  development, maintenance and function in normal and disease states 22nd FRT –Fondation Rene Touraine Annual Scientific Meeting
- Place of Presentation
  Paris（France）
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of autoimmunity and tumor immunity by regulatory T cells2014
- Author(s)
  坂口志文
- Organizer
  日本研究皮膚科学会第39回年次学術大会・総会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪）
- Year and Date
  2014-12-14
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Genetic and epigenetic control of regulatory T cell development2013
- Author(s)
  Shimon Sakaguchi
- Organizer
  JST-CREST International Symposium Frontiers in Immunology and Inflammation From Molecules to Disease
- Place of Presentation
  ＪＳＴ本部（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] The Molecular Basis of Treg-Mediated Suppression2013
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 2nd NIF Winter School 2013 on Advanced Immunology
- Place of Presentation
  SIgN(Singapore)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T-cells modulate T-follicular helper and germinal center formation via CTLA-42013
- Author(s)
  Wing JB, Ise W, Kurosaki T, Sakaguchi S.
- Organizer
  Gordon research conference T Follicular Helper Cells: Basic Discoveries and Clinical Applications
- Place of Presentation
  The Chinese University of Hong Kong, Hong Kong, China
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] Regulatory T-cells modulate T-follicular helper and germinal center formation via CTLA-42013
- Author(s)
  Wing JB, Ise W, Kurosaki T, Sakaguchi S.
- Organizer
  Kyoto T Cell Conference 2013
- Place of Presentation
  Shiran Kaikan, Kyoto University, Kyoto
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] Regulatory T-cells modulate T-follicular helper and germinal center formation via CTLA-42013
- Author(s)
  Wing JB, Ise W, Kurosaki T, Sakaguchi S.
- Organizer
  Annual meeting of Japanese society for Immunology
- Place of Presentation
  Makuhari Messe, Chiba.
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] 遺伝子変異と発病の間のブラックボックス解明のために構造生物学ができること2012
- Author(s)
  坂口志文
- Organizer
  日本学術会議公開シンポジウム
- Place of Presentation
  日本学術会議大講堂(東京)(招待講演)
- Year and Date
  2012-01-09
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, Regulatory T cells, and Autoimmune Diseases2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  橋本病百周年記念国際シンポジウム International Symposium II
- Place of Presentation
  アクロス福岡（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Molecular basis of regulatory T cells development and their functional stability2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  Centre for Immune Regulation University of Oslo
- Place of Presentation
  Grand Hotel (Norway)(招待講演)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Molecular basis of regulatory T cells development and their functional stability2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  Helmholtz Centre for Infection Research
- Place of Presentation
  Braunschweig (Germany)(招待講演)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞を標的とした免疫応答制御の展望2012
- Author(s)
  坂口志文
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Control of Regulatory T cell Development2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
- Place of Presentation
  シャトレーゼ　ガトーキングダム札幌（札幌）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2012
- Author(s)
  坂口志文
- Organizer
  第13回運動器科学研究会
- Place of Presentation
  アピカルイン京都（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Molecular basis of regulatory T cells development and their functional stability2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  Max Planck Institute of Neurobiology
- Place of Presentation
  MPI fur Neurobiologie (Germany)(招待講演)
- Year and Date
  2012-03-22
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for Immune Regulation2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  International symposium : Infection, immunity and cacer
- Place of Presentation
  芝蘭会館(京都)(招待講演)
- Year and Date
  2012-01-16
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2012
- Author(s)
  坂口志文
- Organizer
  第14回白馬シンポジウムin京都
- Place of Presentation
  京都市国際交流会館（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic basis of the development and function of natural Foxp3-expressing regulatory T cells2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  novo nordisk innovation summit Tokyo 2012 chronic inflammation and autoimmune diseases
- Place of Presentation
  シェラトン都ホテル東京（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2012
- Author(s)
  坂口志文
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Basis of Regulatory T Cell Function in Their Clinical Application2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  FOCiS (Federation of Clinical Immunology Societies)2012
- Place of Presentation
  Vancouver,BC<, Canada(Vancouve,r Canada)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Control of Regulatory T cellFunction2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  3rd European Congress of Immunology
- Place of Presentation
  University of Glasgow(Glasgow, UK)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Treg development and function2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  International Symposium Migration and Regulation : Managing immune-mediated diseases
- Place of Presentation
  Berlin-Brandenburgische Akademie der Wissenschaften, Berlin (Germany)(招待講演)
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2012
- Author(s)
  坂口志文
- Organizer
  The 4th BMC(Brainstorming MedicalConference)
- Place of Presentation
  泉ガーデンコンファレンスセンター（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Roles of concurrent epigenetic conversion and Foxp3 expression for the development of regulatory T cells2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  Winter School 2012 on Advanced Immunology
- Place of Presentation
  淡路夢舞台(兵庫)(招待講演)
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Roles of concurrent epigenetic conversion and Foxp3 expression for the development and function of regulatory T cells2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  International Symposium Dynamism of Immune Reactions & Regulation
- Place of Presentation
  大阪国際会議場（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2012
- Author(s)
  坂口志文
- Organizer
  第66回日本栄養・食糧学会
- Place of Presentation
  東北大学（仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Control of Regulatory T cell Development2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 12th International Symposium on Dendritic Cells
- Place of Presentation
  EXCO,Deagu(Daegu Korea)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞と自己免疫病2012
- Author(s)
  坂口志文
- Organizer
  第２回T-cell Camp
- Place of Presentation
  ヒルトン小田原リゾート＆スパ（小田原）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞と免疫寛容、免疫制御2012
- Author(s)
  坂口志文
- Organizer
  第14回日本免疫学会免疫サマースクール2012
- Place of Presentation
  ラフォーレ那須（那須）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Control of Regulatory T cell Development2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  The Third International Conference on Regulatory T Cells and Helper T Cell Subsets and Clinical Application in Human Diseases
- Place of Presentation
  Renaissance Shanghai Pudong Hotel(Shanghai China)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and Epigenetic Control of Regulatory T cell Development and Function2012
- Author(s)
  Shimon Sakaguchi
- Organizer
  French-Japanese Meeting
- Place of Presentation
  フランス大使館（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T Cells for immunological tolerance and immune homeostasis2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  8^<th> Nestle International Nutrition Symposium Nutrition & the Immune System
- Place of Presentation
  Lausanne (Switzerland)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  第62回未来医療セミナー
- Place of Presentation
  大阪大学医学部講義棟C講堂(大阪)(招待講演)
- Year and Date
  2011-04-20
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T Cells for immunological self-tolerance and immune homeostasis2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  14^<th> Australasian Autoimmunity Workshop
- Place of Presentation
  The University of Queens land(Australia)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Autoimmune arthritis caused by systemic alteration of the T cell immune system2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  39^<th> Congress of the German Society of Rheumatology
- Place of Presentation
  ICM&ndash InternationalCongrees Centre Munich( Germany)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immune tolerance and homeostasis2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  nstitut Pasteur, Immunology Department Seminar
- Place of Presentation
  Paris(France)(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  第21回日本サイトメトリ-学会学術集会
- Place of Presentation
  京都市国際交流会館(京都)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Induction of tumor immunity by targeting regulatory T cells2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  Joint Symposium of Seoul St.Mary's Hop, Osaka Univ.Postech
- Place of Presentation
  Seoul St, Mary's Hospital (Korea)(招待講演)
- Year and Date
  2011-12-19
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Biology of Regulatory T Cells2011
- Author(s)
  坂口志文
- Organizer
  BMT Tandem Meetings
- Place of Presentation
  ハワイ(アメリカ)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells, and self-tolerance2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  Advances in Targeted Therapies
- Place of Presentation
  Hotel Radisson Blu (Croatia)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Therapeutic modalities-future prospects2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  The Herrenhausen Symposium on Autoimmunity
- Place of Presentation
  Kloster Seeon, (Germany)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による腫瘍免疫応答の制御2011
- Author(s)
  坂口志文
- Organizer
  第15回日本がん免疫学会総会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  第47回日本移植学会総会
- Place of Presentation
  仙台国際センター(福島県)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  日本免疫学会第13回免疫サマースクール
- Place of Presentation
  ラフォーレ蔵王リゾート&スパ(山形)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immune tolerance and homeostasis2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  Institut Federatif de Recherche Bio-Medicale de Toulouse INSERM
- Place of Presentation
  Toulouse(France)(招待講演)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  第61回日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪(東京)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  自治医科大学大学院特別セミナー
- Place of Presentation
  自治医科大学(栃木)(招待講演)
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of Immune Responses by Regulatory T Cells2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  10^<th> Faculty Research Symposium Frontiers in Biomedical Research
- Place of Presentation
  Cheung Kung Hai Conference Centre (China)(招待講演)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T細胞シグナル、制御性T細胞、自己免疫病2011
- Author(s)
  坂口志文
- Organizer
  東京大学大学院GCOEセミナー
- Place of Presentation
  東京大学(東京)(招待講演)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  久留米大学大学院講義
- Place of Presentation
  久留米大学(福岡)(招待講演)
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] TCR signaling and autoimmune arthritis2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  Australian Rheumatology Association 52^<nd> Annual Scientific Meeting
- Place of Presentation
  Brisbane Convention and Exhibition Centre (Australia)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2011
- Author(s)
  坂口志文
- Organizer
  東京大学医科学研究所大学院特別セミナー
- Place of Presentation
  東京大学(東京)(招待講演)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T Cells for the control of physiological and pathological immune responses2011
- Author(s)
  Shimon Sakaguchi
- Organizer
  6^<th> European Workshop on Immune-Mediated Inflammatory Diseases
- Place of Presentation
  Radisson Blu(France)(招待講演)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells, and self-tolerance.2010
- Author(s)
  坂口志文
- Organizer
  97^<th> Annual Meeting of the American Association of Immunologist
- Place of Presentation
  ボルチモア(アメリカ)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune responses by regulatory T cells.2010
- Author(s)
  坂口志文
- Organizer
  IFReC-New Zealand Immunology Workshop
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Treg cells.2010
- Author(s)
  坂口志文
- Organizer
  14^<th> Congress of Asia Pacific League of Associations for Rheumatology
- Place of Presentation
  香港(中国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for self-tolerance.2010
- Author(s)
  坂口志文
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of Immune Responses by Regulatory T Cells.2010
- Author(s)
  坂口志文
- Organizer
  Gladstone Institute of Virology and Immunology Seminar Series
- Place of Presentation
  サンフランシスコ(アメリカ)
- Year and Date
  2010-05-06
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune responses by regulatory T cells.2010
- Author(s)
  坂口志文
- Organizer
  International Conference in Sapporo 2010
- Place of Presentation
  北海道
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Overview and Mechanisms of Treg Suppression.2010
- Author(s)
  坂口志文
- Organizer
  British Society for Immunology Annual Congress
- Place of Presentation
  リバプール(イギリス)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2010
- Author(s)
  坂口志文
- Organizer
  日本臨床検査自動化学会第42回大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T-cell signaling, regulatory T cells and self-tolerance2010
- Author(s)
  坂口志文
- Organizer
  8^<th> German-Japan Symposium
- Place of Presentation
  クックスハーフェン(ドイツ)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immunological tolerance and immune homeostasis.2010
- Author(s)
  坂口志文
- Organizer
  International Symposium for Immunology of Reproduction (ISIR-Osaka 2010)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and self-tolerance.2010
- Author(s)
  坂口志文
- Organizer
  The 2010 Cold Spring Harbor Asia Conference : Frontier of Immunology in Health & Diseases
- Place of Presentation
  蘇州市(中国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T Cells in Innate and Adaptive Immunity.2010
- Author(s)
  坂口志文
- Organizer
  2010 Keystone Symposia Innate Immunity : Mechanisms Linking with Adaptive Immunity
- Place of Presentation
  ダブリン(アイルランド)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2010
- Author(s)
  坂口志文
- Organizer
  第7回生物学的製剤治療研究会
- Place of Presentation
  横浜
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune responses by regulatory T cells2010
- Author(s)
  Shimon Sakaguchi
- Organizer
  8^<th> EAACI-GAZLEN-Immunology Winter School
- Place of Presentation
  Germany,Gralnau, Garmlsah-Partenklrohan
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2010
- Author(s)
  坂口志文
- Organizer
  第6回皮膚免疫疾患研究会
- Place of Presentation
  大阪
- Year and Date
  2010-04-08
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Construction of regulatory T cells without FoxP3.2010
- Author(s)
  T.Yamaguchi, A.Kishi, M.Osaki, S.Sakaguchi
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Th17 and Treg in inflammatory diseases.2010
- Author(s)
  坂口志文
- Organizer
  14^<th> Congress of Asia Pacific League of Associations for Rheumatology
- Place of Presentation
  香港(中国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Altered TCR signaling as a cause of autoimmune disease.2010
- Author(s)
  坂口志文
- Organizer
  FROM THE LABORATORY TO THE CLINIC : Differences between immunity and inflammation in mice and men : Reasons for translational failures?
- Place of Presentation
  オックスフォード(イギリス)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and self-tolerance.2010
- Author(s)
  坂口志文
- Organizer
  40^<th> Annual Meeting German Society for Immunology
- Place of Presentation
  ライプツヒ(ドイツ)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] State-of-the-Art Address. Regulatory T cells for immunological tolerance.2010
- Author(s)
  坂口志文
- Organizer
  American Transplantation Congress 2010
- Place of Presentation
  サンディエゴ(アメリカ)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells, and self-tolerance.2010
- Author(s)
  Shimon Sakaguchi
- Organizer
  97thAnnual Meeting of the American Association of Immunologist
- Place of Presentation
  Baltimore, USA
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Analysis of epigenetic status in regulatory T cells.2010
- Author(s)
  N.Ohkura, M.Hamaguchi, K.Sugimura, A.Tanaka, N.Sasaki S.Sakaguchi
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] SKGマウスにおける関節炎発症のメカニズム2010
- Author(s)
  坂口志文
- Organizer
  第54回日本リウマチ学会総会・学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for self-tolerance.2010
- Author(s)
  Shimon Sakaguchi
- Organizer
  14thInternational Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] The molecular basis of the development and function of regulatory T cells.2010
- Author(s)
  坂口志文
- Organizer
  The 2010 Fall Conference of The Korean Association of Immunologists
- Place of Presentation
  ソウル(韓国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Keynote lecture Construction of regulatory T cells without Foxp3.2010
- Author(s)
  坂口志文
- Organizer
  The second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases China Tregs/Th17
- Place of Presentation
  上海(中国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御2010
- Author(s)
  坂口志文
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, Treg, and autoimmunity.2010
- Author(s)
  坂口志文
- Organizer
  The second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases China Tregs 2010
- Place of Presentation
  上海(中国)
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling for dominant and recessive self-tolerance2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  ASI(Australasian Society for Immunology)39^<th> Annual Scientific Meeting
- Place of Presentation
  Australia, Canrad Jupiters Queensland
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] CTLA-4 for Treg-mediated suppression, Tolerance and Immunoregulation2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  From basic mechanisms to therapeutic applications, Satellite Symposium of the European Congress of Immunology
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immunological tolerance and immune homeostasis2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  The First International Kishimoto Foundation Symposium Immune Regulation : Present and Future
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Tolerance2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  10^<th> FIMSA(Federation of Immunological Society of Asia-Oceania)Advanced Immunology Training Course
- Place of Presentation
  Australia, Tanga looma
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] CTLA-4-dependent mechanism of Treg-mediated in vivo and in vitro suppression.2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  WORLD IMMUNE REGULATION MEETING-III
- Place of Presentation
  Davos, Switzerland
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immune tolerance and homeostasis towards their clinical use2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  TWINCORE-Symposium Infection Research and Beyond
- Place of Presentation
  Hannover Germany
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] CTLA-4 Dependent Mechanism of Treg-Mediated In Vivo and In Vitro Suppression in Tumor Immunity2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  Control of Cancer Immunosuppression The Challenge for Cancer Vaccine Development The XVII^<th> Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Series
- Place of Presentation
  New York USA
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and self-tolerance.2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  1^<st> International Conference on Immune Tolerance
- Place of Presentation
  Boston U.S.A.
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune response by regulatory T cells2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  45^<th> Joint Committee Meeting Japan-U.S. Cooperative Medical Science Program
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and self-tolerance.2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 5^<th> International Workshop of Kyoto T Cell Conference.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and autoimmunity.2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  Cellular and Genetic View on Autoimmunity. RCAI-JSI International Symposium on Immunology 2009
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Suppression Mechanisms of Foxp3^+ Regulatory T Cells2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  FOCIS 2009
- Place of Presentation
  San Francisco USA
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] T cell signaling, regulatory T cells and autoimmunity.2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  Tolerance and Development. The Foundation des Treilles
- Place of Presentation
  Tourtour France
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immune tolerance and tumor immunity2009
- Author(s)
  Shimon Sakaguchi
- Organizer
  International Symposium on Immunotherapy and immunodeficiency
- Place of Presentation
  Heidelberg, Germany
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for the control of immunological diseases.2008
- Author(s)
  Shimon Sakaguchi
- Organizer
  2008 Keio Medical Science Prize Commemorative Symposium
- Place of Presentation
  東京
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T cells for immune tolerance and homeostasis2008
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 4th Congress of the Federation of Immunology Societies of Asia-Oceania 2008
- Place of Presentation
  Taipei Taiwan
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Roleof regulatory Tcell intorelace and autoimmunity2008
- Author(s)
  Shimon Sakaguchi
- Organizer
  EurAPS International Symposium on Molecular Background of tolerance and Autoimmunity
- Place of Presentation
  Helsinki, Finland
- Year and Date
  2008-04-10
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T-cells control antigen-specific Tfh expansion and humoral immune responses via CTLA-4
- Author(s)
  Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
- Organizer
  The 13th Awaji International Forum on Infection and Immunity in Nara
- Place of Presentation
  Nara Prefectural New Public Hall, Japan
- Year and Date
  2014-09-23 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] 胸腺と末梢の制御性T細胞発生におけるSATB1の役割
- Author(s)
  北川瑤子、大倉永也、廣田圭司、安田佳子、谷内一郎、近藤元就、重松照美、坂口志文
- Organizer
  第24回Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル(京都）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of Tumor Immunity by Regulatory T Cells.
- Author(s)
  Shimon Sakaguchi
- Organizer
  IAAO(International Academy for Advanced Oncology) Convergence for Breakthroughs in Oncology Therapy
- Place of Presentation
  六本木ヒルズ（東京）
- Year and Date
  2014-08-01 – 2014-08-02
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第2回北摂呼吸器・アレルギー研究会
- Place of Presentation
  大阪大学銀杏会館（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第10回北東北血液研究会
- Place of Presentation
  秋田温泉さとみコンベンションホール（秋田）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T Cells and Immune Tolerance.
- Author(s)
  Shimon Sakaguchi
- Organizer
  Sushruta Lecture Transplantation Update-2015
- Place of Presentation
  Ahmedabad（India）
- Year and Date
  2015-01-09 – 2015-01-11
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Regulatory T-cells control antigen-specific Tfh expansion and humoral immune responses via CTLA-4
- Author(s)
  Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
- Organizer
  The 43rd Annual Meeting of the Japanease Society for Immunology
- Place of Presentation
  Kyoto International Conference Center, Japan
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] Control of Treg cells for immune tolerance
- Author(s)
  Shimon Sakaguchi
- Organizer
  Novo nordisk innovation summit Tokyo
- Place of Presentation
  東京大学医科学研究所（東京）
- Year and Date
  2014-10-01 – 2014-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第12回先端医療センターMonthly Lecture
- Place of Presentation
  先端医療センター（神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第18回千葉基礎・臨床免疫セミナー
- Place of Presentation
  千葉大学医学部（千葉）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞と自己免疫・癌
- Author(s)
  坂口志文
- Organizer
  第57回日本甲状腺学会学術集会
- Place of Presentation
  ナレッジキャピタルコングレコンベンションセンター（大阪）
- Year and Date
  2014-11-13 – 2014-11-15
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of autoimmunity and tumor immunity by regulatory T cells.
- Author(s)
  Shimon Sakaguchi
- Organizer
  RJKEN IMS-JSI International Symposium on Immunology 2014 Decoding Immune Complexity Bench to Bedside
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-06-26 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第33回分子病理学研究会
- Place of Presentation
  宮城蔵王ロイヤルホテル（蔵王）
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Treg-mediated control of the cell fate of autoimmune T cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  The Fourth International Conference on Regulatory T Cells and T Helper Cell Subsets and Clinical Application in Human Diseases
- Place of Presentation
  Shanghai（China）
- Year and Date
  2014-11-01 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  2012 Young Physician Workshop
- Place of Presentation
  京都ブライトンホテル（京都）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Keynote Address Immune Regulation for Cancer Immunotherapy The 45th International Symposium of The Princess Takamatsu Cancer Research Fund
- Author(s)
  Shimon Sakaguchi
- Organizer
  Recent Advances in Cancer Immunotherapy
- Place of Presentation
  パレスホテル東京（東京）
- Year and Date
  2014-11-18 – 2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] 制御性T細胞と腫瘍免疫
- Author(s)
  坂口志文
- Organizer
  第１回癌・免疫若手セミナー
- Place of Presentation
  大阪大学医学部付属病院（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune responses by regulatory T cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  Tri-Institutional Immunology and Microbial Pathogenesis Program Research Seminar Series
- Place of Presentation
  Memorial Sloan-Kettering Cancer Center(New York USA)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Control of immune responses by regulatory T cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  Immunology seminar Series Massachusetts General Hospital
- Place of Presentation
  マサセチューセッツ大学（Boston USA）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第51回補体シンポジウム
- Place of Presentation
  神戸常盤大学（神戸）
- Year and Date
  2014-08-22 – 2014-08-23
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] The genome organizer Satb1 differentially controls thymic and peripheral development of regulatory T cells.
- Author(s)
  4.Kitagawa Yohko, Ohkura Naganari, Hirota Keiji, Adeegbe Olakunle, Yasada Keiko, Kondo Motonari, Taniuchi Ichiro, Kohwi-ShigematuTerumi, Sakaguchi Shimon
- Organizer
  第43回日本免疫学会総会・学術総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Epigenetic changes and Treg cell development.
- Author(s)
  Shimon Sakaguchi
- Organizer
  European Academy of Allergy and Clinical Immunology Congress 2014
- Place of Presentation
  Copenhagen（Denmark）
- Year and Date
  2014-06-07 – 2014-06-11
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] The soluble form of CTLA-4 in regulatory T cells-mediated suppression
- Author(s)
  Osaki Motonao, Sakaguchi Shimon
- Organizer
  第43回日本免疫学会総会・学術総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] APC and T Regs
- Author(s)
  Shimon Sakaguchi
- Organizer
  KEYSTONE SYMPOSIA Dendritic Cells and Macrophages Reunited
- Place of Presentation
  Montreal（Canada）
- Year and Date
  2015-03-08 – 2015-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of immune responses by regulatory T cells.
- Author(s)
  Shimon Sakaguchi
- Organizer
  The 4th NIF Winter School on Advanced Immunology
- Place of Presentation
  Singapore
- Year and Date
  2015-01-18 – 2015-01-23
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Regulatory T-cells control antigen-specific Tfh expansion and humoral immune responses via CTLA-4
- Author(s)
  Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
- Organizer
  Keystone Symposium: T Cells: Regulation and Effector Function (D3)
- Place of Presentation
  Snowbird Resort, Snowbird, Utah USA
- Year and Date
  2015-03-29 – 2015-04-02
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  第51回日本消化器免疫学会総会
- Place of Presentation
  京都大学医学部芝蘭会館（京都）
- Year and Date
  2014-07-10 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Regulatory T cells in autoimmune diseases
- Author(s)
  Shimon Sakaguchi
- Organizer
  橋本病百周年記念国際シンポジウム International Symposium I
- Place of Presentation
  アクロス福岡（福岡）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Genetic and epigenetic basis of Treg cell development and function.
- Author(s)
  Shimon Sakaguchi
- Organizer
  Academy of Immunology and Microbiology Workshop on Immunology 2014
- Place of Presentation
  Pohan（Korea）
- Year and Date
  2014-11-09 – 2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of Immune Responses by Regulatory T cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  KEYSTONE SYMPOSIA T Cells: Regulation and Effector Function
- Place of Presentation
  Utah（USA）
- Year and Date
  2015-03-29 – 2015-04-03
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Genetic and Epigenetic Control of Regulatory T cell Function
- Author(s)
  Shimon Sakaguchi
- Organizer
  National Institute for Medical Research
- Place of Presentation
  National Institute for Medical Research(Mill Hill, UK)
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] 制御性T細胞による免疫応答制御
- Author(s)
  坂口志文
- Organizer
  大阪医科大学大学院特別講義
- Place of Presentation
  大阪医科大学（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007
[Presentation] Regulatory T-cells control antigen-specific Tfh expansion and humoral immune responses via CTLA-4
- Author(s)
  Wing, JB. Ise, W. Kurosaki, T. Sakaguchi, S.
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases
- Place of Presentation
  Renaissance Hotel, Shanghai, China
- Year and Date
  2014-11-01 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25860356
[Presentation] Regulatory T Cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  Development, Maintenance and Function in Normal and Disease States The 2014 Fall Conference of Korean Association of Immunologists
- Place of Presentation
  Seoul（Korea）
- Year and Date
  2014-11-06 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-26253030
[Presentation] Control of immune responses by regulatory T cells
- Author(s)
  Shimon Sakaguchi
- Organizer
  Immunology seminar Series Harvard Medical School
- Place of Presentation
  ハーバード大学（Boston USA）
- Invited
- Data Source
  KAKENHI-PROJECT-20002007

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Sakaguchi Shimon 坂口 志文

SAKAGUCHI Shimon 坂口 志文

Research Projects

Research Products

Co-Researchers

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseasesPrincipal Investigator

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Study of the function and development of regulatory T cellsPrincipal Investigator

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Molecular basis and therapeutic target for autoimmune arthritisPrincipal Investigator

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制御性Ｔ細胞による腫瘍内ＣＤ８＋Ｔ細胞の活性抑制に関する研究Principal Investigator

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Molecular basis of the function and generation of Foxp3-expressing regulatory T cellsPrincipal Investigator

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Immune tolerance and regulation towards understanding and cure of autoimmune diseasePrincipal Investigator

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Sakaguchi Shimon 坂口志文

SAKAGUCHI Shimon 坂口志文

[Book] 臨床免疫・アレルギー科　Vol75 No.32021

[Book] 実験医学　Vol.38 No.17（増刊）2020

[Book] 週刊医学のあゆみ　Vol.275 No.12020