Nakanishi Takeo 中西猛夫

… Alternative Names

NAKANISHI Takeo 中西猛夫

中西猛夫ナカニシタケオ

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Researcher Number	30541742
Other IDs
External Links
Affiliation (Current)	2025: 高崎健康福祉大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 高崎健康福祉大学, 薬学部, 教授 2009 – 2018: Kanazawa University, 薬学系, 准教授 2015: 金沢大学, 医薬保健研究域薬学系, 准教授
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Applied pharmacology / Physical pharmacy / Medical pharmacy / Biological pharmacy Except Principal Investigator Medical pharmacy / Radiation science / Biological pharmacy
Keywords	Principal Investigator トランスポーター / 炎症 / プロスタグランジン / マクロファージ / 輸送体 / 化学療法 / 薬物性肝障害 / 脂肪肝 / ミトコンドリア / 肝炎 … More / うつ病 / Maxi-Cl / SLCO2A1 / うつ / 中枢神経系 / 膜輸送体 / 肺線維症 / 薬理学 / 薬学 / 酵素 / 発現 / プロスタグランジン輸送体 / 薬物代謝酵素・トランスポーター / OATP2A1/SLCO2A1 / 線維化 / 肺 / 大腸癌 / 開口分泌 / 免疫 / 内毒素 / 抗炎症薬 / 発熱 / 白血病 / 幹細胞 / がん / OATP / 前立腺がん / 去勢抵抗性 / ホルモン / 前立腺癌 / 薬物動態・代謝学 / 蛍光診断 / 光力学診断 / 薬物排泄 / プロトポルフォリン / 有機アニオン / 光力学療法 / フェロキラターゼ / プロトポルフィリン / アミノレブリン酸 … More Except Principal Investigator 薬物間相互作用 / トランスポーター / 輸送体 / 薬物動態 / 予測マーカー / 発現調節 / 筋毒性 / 筋肉 / 消化管 / 食品 / 個体間変動 / 薬食相互作用 / ナノ粒子 / マイクロRNA / OATP / 開発戦略 / ポストＦＤＧ製剤 / 腫瘍診断薬 / 機能性分子発現系 / 癌関連トランスポーター / 設計戦略 / 薬物トランスポーター / アミノ酸トランスポーター / ポストFDG 製剤 / 画像診断薬 / 機能性分子安定発現系 / 遺伝子発現解析 / ヒト培養細胞 / 心毒性 / 薬物相互作用 / Local-DDI / Local DDI / シロスタゾール / ドネペジル / BCRP / 分子生物学的研究 / エストロゲン受容体 / 乳がん / エストロゲン前駆体 / 有機アニオン輸送ポリペプチド / MRP2 / 薬物誘導性肝障害 / 可視化 / 胆汁排泄 / 副作用 / 肝細胞 / 生体分子 / 代謝酵素 / 徐放性製剤 / 経口吸収 / 薬物動態学 / 薬学 Less

Dysfunction of mitochondrial carriers and steatohepatitisPrincipal Investigator
- Principal Investigator
  
  中西猛夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Takasaki University of Health and Welfare
An implication of transporter-mediated regulation of brain PG concentration for mental diseasesPrincipal Investigator
- Principal Investigator
  
  Nakanishi Takeo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Takasaki University of Health and Welfare
Micro RNA-mediated expressional regulation of transporters
- Principal Investigator
  
  Ikumi Tamai
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Study on prostaglandin transporter as a novel target for anti-inflammatory drugsPrincipal Investigator
- Principal Investigator
  
  Nakanishi Takeo
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Development strategy of tumor diagnostic agent by system upregulated functional biomolecule based on expression analysis of tumor associated transporter
- Principal Investigator
  
  KAWAI Keiichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kanazawa University
Role of prostaglandin transporter in pulmonary fibrosis and its therapeutic significancePrincipal Investigator
- Principal Investigator
  
  Nakanishi Takeo
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Local drug-drug interaction of donepezil with cilostazol at BCRP transporter
- Principal Investigator
  
  Tamai Ikumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Impact of transporters for uptake of estrogen precursors on progression of breast cancer cells
- Principal Investigator
  
  JUN Matsumoto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  International University of Health and Welfare
Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug Absorption
- Principal Investigator
  
  SHIRASAKA Yoshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
New rational for chemotherapy targeting transporters expressed in cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Takeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Application of Sandwich-cultured hepatocytes for analysis of drug-drug interaction on bile canalicular transporters
- Principal Investigator
  
  TAMAI Ikumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acidPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Takeo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
生体膜の物質輸送機構の解明と膜輸送担体を介した薬物送達法の開発Principal Investigator
- Principal Investigator
  
  中西猛夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University

[Book] 次世代吸入製剤とデバイスの開発　『肺胞上皮細胞におけるトランスポーターの発現・機能』2018
- Author(s)
  中西猛夫
- Total Pages
  252
- Publisher
  シーエムシー出版
- ISBN
  9784781313535
- Data Source
  KAKENHI-PROJECT-15H04755
[Book] Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development2016
- Author(s)
  4.Gustavsson L, Bosquillon C, Gumbleton M, Hegelund-Myrba T, Nakanishi T, Price D, Tamai I, Zhou X-H.
- Total Pages
  35
- Publisher
  The Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A102024
- Author(s)
  Nakamura Yoshinobu、Ito Masa-aki、Hoshino Yukino、Matsuoka Isao、Okada Toshiaki、Okada Yasunobu、Nakanishi Takeo
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 326 Issue: 4 Pages: C1042-C1053
- DOI
  10.1152/ajpcell.00701.2023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15295, KAKENHI-PROJECT-20K07018, KAKENHI-PROJECT-20K16010
[Journal Article] N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A12023
- Author(s)
  Nakamura Y, Aizawa C, Kawata H, Nakanishi T
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 165 Pages: 106714-106714
- DOI
  10.1016/j.prostaglandins.2023.106714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07018, KAKENHI-PROJECT-22K15295
[Journal Article] Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A12022
- Author(s)
  Nakamura Yoshinobu、Kozakai Hina、Nishio Tsubura、Yoshida Kazuki、Nakanishi Takeo
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 44 Pages: 100452-100452
- DOI
  10.1016/j.dmpk.2022.100452
- NAID
  210000188858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22719, KAKENHI-PROJECT-20K07018
[Journal Article] Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action2021
- Author(s)
  Nakanishi T, Nakamura Y, Umeno J
- Journal Title
  
  Pharmacol Ther
  
  Volume: 223 Pages: 107803-107803
- DOI
  10.1016/j.pharmthera.2021.107803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07018, KAKENHI-PROJECT-20K22719
[Journal Article] Experimental evidence for resecretion of PGE2 across rat alveolar epithelium by OATP2A1/SLCO2A1-mediated transcellular transport2019
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 368 Issue: 2 Pages: 317-325
- DOI
  10.1124/jpet.118.249789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Contribution of equilibrative　nucleoside　transporters(s)　to　intestinal　basolateral　and　apical　transport　of　anticancer　trifluridine2018
- Author(s)
  Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 39 Issue: 1 Pages: 38-46
- DOI
  10.1002/bdd.2110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05111, KAKENHI-PROJECT-16K15158
[Journal Article] Foreword2018
- Author(s)
  Nakanishi T, Tamai I, Deguchi Y
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 9 Pages: 1322-1323
- DOI
  10.1248/bpb.b18-ctf4109
- NAID
  130007480024
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] 細胞内PGE2シグナルにおけるOATP2A1の役割2018
- Author(s)
  中西猛夫
- Journal Title
  
  細胞
  
  Volume: 50 Pages: 151-153
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Membrane Transporters Contributing to PGE<sub>2</sub> Distribution in Central Nervous System2018
- Author(s)
  Nakamura Y, Nakanishi T, Tamai I
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 9 Pages: 1337-1347
- DOI
  10.1248/bpb.b18-00169
- NAID
  130007479901
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Roles of organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1) in regulating the pathophysiological actions of prostaglandins2018
- Author(s)
  Nakanishi T, Tamai I
- Journal Title
  
  AAPS J
  
  Volume: 20 Issue: 1 Pages: 13-13
- DOI
  10.1208/s12248-017-0163-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer2017
- Author(s)
  Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16567-16567
- DOI
  10.1038/s41598-017-16738-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Impact of FDA-approved drugs on the prostaglandin transporter OATP2A1/SLCO2A12017
- Author(s)
  Kamo S, Nakanishi T, Aotani R, Nakamura Y, Gose T, Tamai I
- Journal Title
  
  J Pharm Sci
  
  Volume: 未定 Issue: 9 Pages: 2483-2490
- DOI
  10.1016/j.xphs.2017.04.046
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Impact of FDA-approved drugs on the prostaglandin transporter OATP2A1/SLCO2A12017
- Author(s)
  Kamo S, Nakanishi T, Aotani R, Nakamura Y, Gose T, Tamai I
- Journal Title
  
  J Pharm Sci
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15181
[Journal Article] Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs.2017
- Author(s)
  Ehrhardt C, Beckman P, Couet W, Edwards C, Forbes B, Friden M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R
- Journal Title
  
  J Pharm Sci
  
  Volume: 未定 Issue: 9 Pages: 2234-2244
- DOI
  10.1016/j.xphs.2017.04.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755, KAKENHI-PROJECT-17K19482, KAKENHI-PROJECT-26293033, KAKENHI-PROJECT-15K08074
[Journal Article] Association of miR-145 with statin-induced skeletal muscle toxicity in human rhabdomyosarcoma RD cells.2017
- Author(s)
  Saito S, Nakanishi T, Shirasaki Y, Nakajima M, Tamai I.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15158
[Journal Article] プロスタグランジン輸送体が関わるPGE2分泌機構の提唱2017
- Author(s)
  中西猛夫, 玉井郁巳
- Journal Title
  
  Bio Clinica
  
  Volume: 32 Pages: 1117-1121
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Role of OATP2A1 in PGE2 secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.2016
- Author(s)
  Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I.
- Journal Title
  
  Exp Cell Res
  
  Volume: 341(2) Issue: 2 Pages: 123-131
- DOI
  10.1016/j.yexcr.2016.02.002
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15181
[Journal Article] Local drug-drug interactoin of donepezil with cilostazol at breast cancer resistance protein (ABCG2) increases drug accumulation in heart2016
- Author(s)
  Takeuchi R, Shinozaki K, Nakanishi T, Tamai I
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 44 Issue: 1 Pages: 68-74
- DOI
  10.1124/dmd.115.066654
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670075
[Journal Article] Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.2016
- Author(s)
  Gose T, Nakanishi T, Kamo S, Shimada H, Otake K, Tamai I.
- Journal Title
  
  Prostaglandins Other Lipid Mediat.
  
  Volume: 122 Pages: 10-17
- DOI
  10.1016/j.prostaglandins.2015.12.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.2015
- Author(s)
  Shimada H, Nakamura Y, Nakanishi T, Tamai I.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 98(4) Issue: 4 Pages: 629-638
- DOI
  10.1016/j.bcp.2015.10.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15181, KAKENHI-PROJECT-15H04755
[Journal Article] [14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells.2015
- Author(s)
  Ono M, Oka S, Okudaira H, Nakanishi T, Mizotani A, Kobayashi M, Schuster DM, Goodman MM, Shirakami Y, Kawai K.
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 42 Issue: 11 Pages: 887-892
- DOI
  10.1016/j.nucmedbio.2015.07.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09949, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-25293260
[Journal Article] Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis2015
- Author(s)
  Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I.
- Journal Title
  
  PLoS One
  
  Volume: 10(4) Issue: 4 Pages: e0123895-e0123895
- DOI
  10.1371/journal.pone.0123895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells2015
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Yoshiyuki Okubo, Nobumitsu Shiina, Kaoru Fujisaki, Takeshi Nagashima, Yukio Nakatani, Ikumi Tamai, Harumi Yamada, Hiroshi Takeda and Itsuko Ishii
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 30 Issue: 2 Pages: 133-141
- DOI
  10.1016/j.dmpk.2014.10.005
- NAID
  210000170465
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25893224
[Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.2014
- Author(s)
  Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I.
- Journal Title
  
  Pharm Res.
  
  Volume: In Press Issue: 8 Pages: 2035-2043
- DOI
  10.1007/s11095-014-1305-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B12014
- Author(s)
  Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I
- Journal Title
  
  Pharm Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions2013
- Author(s)
  Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I
- Journal Title
  
  J Pharm Sci
  
  Volume: 102(9) Pages: 3418-3426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1- mediated drug absorption2013
- Author(s)
  Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, and Tamai I
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41(3) Pages: 615-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013
- Author(s)
  Shirasaka Y., Shichiri M, Nakanishi T., and Tamai I.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 1 Pages: 280-288
- DOI
  10.1002/jps.23357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013
- Author(s)
  Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 9 Pages: 3418-3426
- DOI
  10.1002/jps.23653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] A Putative Role of Organic Anion Transporting Polypeptides (OATPs) In Cell Survival of Hormone-Dependent Breast and Prostate Cancers2013
- Author(s)
  Nakanishi T, Tamai I
- Journal Title
  
  J Cancer Res Therap Oncol
  
  Volume: 1 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590176
[Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide.2012
- Author(s)
  Arakawa H., Shirasaka Y., Haga M., Nakanishi T., and Tamai I.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 33 Issue: 6 Pages: 332-341
- DOI
  10.1002/bdd.1809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.2012
- Author(s)
  Shirasaka Y., Mori T., Shichiri M., Nakanishi T., and Tamai I.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: In press
- NAID
  130004463259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites2012
- Author(s)
  Shirasaka Y, Mori T, Shichiri M, Nakanishi T, and Tamai I
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27(3) Pages: 360-364
- NAID
  130004463259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites.2012
- Author(s)
  Nakanishi T, Ikenaga M, Fukuda H, Matsunaga N, Tamai I.
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 263 Pages: 244-250
- Data Source
  KAKENHI-PROJECT-23659076
[Journal Article] Application ofquantitative time-lapse imaging(QTLI) for evaluation of Mrp2-baseddrug-drug interaction induced byliver metabolites.2012
- Author(s)
  Nakanishi T, Ikenaga M, Fukuda H, Matsunaga N, Tamai I
- Journal Title
  
  Toxicol ApplPharmacol
  
  Volume: 263(2) Pages: 244-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659076
[Journal Article] Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.2012
- Author(s)
  Arakawa H, Nakanishi T, Yanagihara C, Nishimoto T, Wakayama T, Mizokami A, Namiki M, Kawai K, Tamai I.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 84 Issue: 8 Pages: 1070-1077
- DOI
  10.1016/j.bcp.2012.07.026
- NAID
  120004997008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590176, KAKENHI-PROJECT-24659558
[Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a52012
- Author(s)
  Arakawa H, Shirasaka Y, Haga M, Nakanishi T, and Tamai I
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 33(6) Pages: 332-341
- NAID
  120004997009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.2011
- Author(s)
  Shirasaka Y., Suzuki K., Nakanishi T., and Tamai I.
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Issue: 9 Pages: 3843-3853
- DOI
  10.1002/jps.22586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Quantitative time-lapse imaging (QTLI)-based analysis of drug-drug interaction mediated by . hepatobiliary transporter, multidrug associated protein 2, in sandwich-cultured rat hepatocytes2011
- Author(s)
  Nakanishi T., Shibue Y., Fukuyama Y., Yoshida K., Fukuda H., Shirasaka Y., Tamai I
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39(6) Issue: 6 Pages: 984-991
- DOI
  10.1124/dmd.111.038059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659076
[Patent] 分子イメージングにより代謝機能を測定するための検査薬2012
- Inventor(s)
  川井恵一、玉井郁巳、国嶋崇隆太、中西猛夫、小林正和
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2012-044231
- Filing Date
  2012-02-29
- Data Source
  KAKENHI-PROJECT-23659076
[Presentation] Do hypotonicity and accessory proteins required for Maxi-Cl channel affect SLCO2A1-mediated prostaglandin E2 transport activity?2023
- Author(s)
  中村吉伸，伊藤政明，星野雪乃，松岡功，中西猛夫
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] Maxi-Clアクセサリータンパク質ANXA2およびS100A10がSLCO2A1のプロスタグランジンE2輸送活性に及ぼす影響2023
- Author(s)
  中村吉伸，伊藤政明，星野雪乃，松岡功，中西猛夫
- Organizer
  第17回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] 肺プロスタグランジン動態解析から見えてきた薬物の経肺吸収における膜輸送体の可能性2022
- Author(s)
  中西猛夫、中村吉伸
- Organizer
  日本薬剤学会第37年会・学術シンポジウム２
- Invited
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] フェノールスルホンフタレインを用いたプロスタグランジン膜輸送体SLCO2A1機能評価2022
- Author(s)
  西尾円来，中村吉伸，小酒井陽菜，吉田一貴，中西猛夫
- Organizer
  日本薬学会第142年会（オンライン）
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] Pathophysiological significance of the prostaglandin transporter SLCO2A1 in lung inflammation2021
- Author(s)
  Nakanishi T
- Organizer
  Physiology 2021 Symposia (On-line), The Physiological Society（英国生理学会）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] Phenol red as a novel substrate of prostaglandin transporter SLCO2A12021
- Author(s)
  中村吉伸，小酒井陽菜，西尾円来，青木澪士，中西猛夫
- Organizer
  日本薬物動態学会　第36年会（オンライン）
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] プロスタグランジン膜輸送体SLCO2A1による海馬PGD2濃度調節2021
- Author(s)
  中村吉伸，中西猛夫
- Organizer
  日本薬学会第141年会(広島)，オンライン
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] SLCO2A1 による脳の領域特異的なプロスタグランジン D2 動態制御機構2020
- Author(s)
  中村吉伸，中西猛夫
- Organizer
  第35回日本薬物動態学会年会，オンライン
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] プロスタグランジン膜輸送体SLCO2A1による中枢神経系におけるPGD2濃度調節機構2020
- Author(s)
  中村吉伸，坂口貴俊，中西猛夫
- Organizer
  第15回トランスポーター研究会年会，オンライン
- Data Source
  KAKENHI-PROJECT-20K07018
[Presentation] Essential contribution of prostaglandin transporter OATP2A1/SLCO2A1 to the febrile response2018
- Author(s)
  Nakamura Y, Nakanishi T, Higuchi K, Okura T, Deguchi Y, Tamai I
- Organizer
  International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Role of OATP2A1/SLCO2A1 in intracellular PGE2 dispositon in murine macrophages2018
- Author(s)
  Sakaguchi T, Nakamura Y, Shimizu J, Nakanishi T, Tamai I
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Essential role of prostaglandin transporter OATP2A1/SLCO2A1 on body temperature regulation during fever2018
- Author(s)
  Nakanishi T
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Functional characterization of prostaglandin transporter OATP2A1/SLCO2A1 in alveolar epithelial cells2018
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Organizer
  The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Effect of cigarette smoke extract on expression and function of prostaglandin transporter (OATP2A1/SLCO2A1).2018
- Author(s)
  Takashima H, Nakanishi T, Honda R, Tamai I
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Post-transcriptional regulation of prostaglandin transporter (OATP2A1/SLCO2A1) during the epithelial-mesenchymal transition2018
- Author(s)
  Komori H, Nakanishi T, Takashima H, Honda R, Tamai I
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Regulatory Effect of Fruit-derived Nanoparticle on Intestinal Transporters2018
- Author(s)
  Daichi Fujita, Toshiki Arai, Yuma Shirasaki, Yui Iwamoto, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15158
[Presentation] Pathophysiological relevance prostaglandin transporter OATP2A1/SLCO2A1 expressed in alveolar epithelial cells2018
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Organizer
  International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] The role of OATP2A1/SLCO2A1 in macrophages in PGE2 disposition in the hypothalamus during fever2018
- Author(s)
  Nakamura Y, Nakanishi T, Shimada H, Tamai I
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Unappreciated roles of organic anion transporting polypeptides (OATPs) in human diseases2017
- Author(s)
  Nakanishi T.
- Organizer
  University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Hormone-Responsive Cancer Program Special Seminar
- Place of Presentation
  Baltimore, MD, USA
- Year and Date
  2017-03-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体OATP2A1/SLCO2A1によるPGE2の細胞内動態調節作用2017
- Author(s)
  清水淳也，御勢智香，中村吉伸，中西猛夫，玉井郁巳
- Organizer
  日本薬学会北陸支部第129回例会
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体 OATP2A1/SLCO2A1阻害作用を持つ医薬品の探索2017
- Author(s)
  Nakanishi T, Kamo S, Aotani R, Tamai I.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  Sendai, Japan
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] LPS投与マウスの脳内PGE2動態におけるOatp2a1/Slco2a1の役割2017
- Author(s)
  中村吉伸，中西猛夫，樋口慧，黄倉崇，出口芳春，玉井郁巳
- Organizer
  日本薬物動態学会第32年会
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体OATP2A1/SLCO2A1阻害作用を持つ医薬品の探索2017
- Author(s)
  Nakanishi T, Kamo S, Aotani R, Tamai I.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  Sendai, Japan
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体OATP2A1を介したⅠ型肺胞上皮細胞におけるPGE2経細胞輸送制御2017
- Author(s)
  高島大樹，中西猛夫，玉井郁巳
- Organizer
  日本薬物動態学会第32年会
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体OATP2A1/SLCO2A1欠損マウスにおける内毒素の発熱作用2017
- Author(s)
  中村吉伸，中西猛夫，清水淳也，玉井郁巳
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] マクロファージにおけるプロスタグランジン輸送体 OATP2A1/SLCO2A1 を介した PGE2 分泌調節機構2017
- Author(s)
  清水淳也, 御勢智香, 中村吉伸, 中西猛夫, 玉井郁巳
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Effect of Fruit-derived nanoparticle on intestinal transporters2017
- Author(s)
  Toshiki Arai, Yuma Shirasaki, Daichi Fujita, Takeo Nakanishi, Ikumi Tamai
- Organizer
  第32回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-16K15158
[Presentation] 血管内皮細胞遊走能におけるプロスタグランジン輸送体 OATP2A1 の役割2017
- Author(s)
  Maruyama S, Nakanishi T, Tamai I
- Organizer
  日本薬学会第137年会
- Place of Presentation
  Sendai, Japan
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] 内毒素による脳内プロスタグランジン動態変化におけるOATP2A1の役割2017
- Author(s)
  中村吉伸，中西猛夫，樋口慧，黄倉崇，出口芳春，玉井郁巳
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] 果物由来ナノ粒子が及ぼす小腸輸送体への影響2017
- Author(s)
  荒井俊樹、白崎佑磨、小森久和、中西猛夫、玉井郁巳
- Organizer
  日本薬学会年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15158
[Presentation] Alteration in PGE2 disposition by subcellular localization of prostaglandin transporter, OATP2A1/SLCO2A12016
- Author(s)
  Nakanishi T, Tamai I.
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Davis, CA, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] プロスタグランジン輸送体 Slco2a1 遺伝子欠損マウスにおけるリポ多糖誘発性体温上昇の抑制2016
- Author(s)
  中村吉伸、中西猛夫、島田紘明、清水淳也、玉井郁巳
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] プロスタグランジン輸送体OATP2A1機能阻害によるマウスマクロファージPGE2動態の変動2016
- Author(s)
  Gose T, Nakanishi T, Tamai I.
- Organizer
  日本薬物動態学会31年会
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] nflammatory Fever Induced by LPS is Attenuated in Macrophage Specific OATP2A1 Knockout (Mφ-Slco2a1-/-) Mice2016
- Author(s)
  Shimizu J, Nakamura Y, Shimada H, Maruyama S, Nakanishi T, Tamai I.
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] 炎症性疾患におけるプロスタグランジントランスポーターの新規役割2016
- Author(s)
  Nakanishi T.
- Organizer
  日本薬物動態学会第31年会シンポジウム12
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] Unappreciated role of prostaglandin transporter OATP2A1 in inflammatory diseases.2016
- Author(s)
  Nakanishi T.
- Organizer
  The 11th International Meeting of the International Society for the Study of Xenobiotics (ISSX)
- Place of Presentation
  Busan, Korea
- Year and Date
  2016-06-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Prostaglandin Transporter OATP2A1 Contributes to PGE2 Secretion from Macrophages in Response to Inflammatory Stimulation2016
- Author(s)
  Nakamura Y, Nakanishi T, Shimada H, Tamai I.
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2016-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] 炎症性疾患におけるプロスタグランジントランスポーターの新規役割2016
- Author(s)
  Nakanishi T.
- Organizer
  日本薬物動態学会第31年会シンポジウム12
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] ブレオマイシン誘導性肺線維症モデル炎症期におけるプロスタグランジン輸送体 OATP2A1 の役割2016
- Author(s)
  崎山栞、中西猛夫、黄舒瑩、島田紘明、玉井郁巳
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] FDA承認薬ライブラリを用いたOATP2A1阻害薬の探索2016
- Author(s)
  Aotani R, Nakanishi T, Kamo S, Gose T, Tamai I.
- Organizer
  日本薬物動態学会31年会
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] 肺線維症モデルを用いた炎症におけるプロスタグランジン輸送体OATP2A1の役割の検討2016
- Author(s)
  Nakanishi T, Tamai I.
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Unappreciated role of prostaglandin transporter OATP2A1 in inflammatory diseases.2016
- Author(s)
  Nakanishi T.
- Organizer
  The 11th International Meeting of the International Society for the Study of Xenobiotics
- Place of Presentation
  Busan, Korea
- Year and Date
  2016-06-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] FDA承認薬ライブラリを用いたOATP2A1阻害薬の探索2016
- Author(s)
  Aotani R, Nakanishi T, Kamo S, Gose T, Tamai I.
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Attenuation of endotoxin-induced fever in prostaglandin transporter OATP2A1 global and macrophage-specific knockout mice.2016
- Author(s)
  Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Tamai I.
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Conference
- Place of Presentation
  Lawrence, KS、USA
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] プロスタグランジン輸送体OATP2A1機能阻害によるマウスマクロファージPGE2動態の変動2016
- Author(s)
  Gose T, Nakanishi T, Tamai I.
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  Matsumoto, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Role of Prostaglandin Transporter OATP2A1 in Inflammatory Phase in Bleomycin-induced Pulmonary Fibrosis2016
- Author(s)
  Nakanishi T, Sakiyama S, Kou J, Tamai I.
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2016-06-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Pyrogenic effect of endotoxin is attenuated in organic anion transporting polypeptide (OATP) 2A1 knockout (Slco2a1-/-) mice.2015
- Author(s)
  中村吉伸、中西猛夫、清水淳也、島田紘明、玉井郁巳
- Organizer
  日本薬物動態学会29年会
- Place of Presentation
  東京タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] ABC輸送体上での薬物相互作用に起因するDonepezilの心毒性リスク2015
- Author(s)
  Takeuchi R, Shinozaki K, Nakanishi T, Tamai I.
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26670075
[Presentation] OATP2A1のプロスタグランジンE2動態調節を介した炎症制御に関する研究2015
- Author(s)
  中西猛夫、中村吉伸、島田紘明、御勢智香、黄舒瑩、崎山栞、玉井郁巳
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] The Role of OATP2A1/SLCO2A1 in PGE2 Secretion from Macrophages.2015
- Author(s)
  島田紘明、中西猛夫、中村吉伸、丸山詩央、玉井郁巳
- Organizer
  日本薬物動態学会29年会
- Place of Presentation
  東京タワーホール船堀
- Year and Date
  2015-11-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] FDA承認薬ライブラリを用いたプロスタグランジントランスポーターOATP2A1の阻害剤探索2015
- Author(s)
  加茂駿介、中西猛夫、青谷梨加、御勢智香、玉井郁巳
- Organizer
  日本薬学会北陸支部第127回例会
- Place of Presentation
  富山大学薬学部
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] プロスタグランジン輸送体OATP2A1は肺を線維症から保護する2015
- Author(s)
  中西猛夫
- Organizer
  第10回トランスポーター研究会・中堅若手シンポジウム（招待講演）
- Place of Presentation
  慶応大学芝キャンパス
- Year and Date
  2015-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Transport Mechanism and Androgen-stimulated Uptake of Amino Acid PET Tracer [18F]Fluciclovine (anti-[18F]FACBC) in Primary and Castration-resistant Prostate Cancer Cells.2015
- Author(s)
  Ono M., Okudaira H., Oka S., Nakanishi T, Mizokami A, Kobayashi M., Schuster D.M., Goodman M.M., Yoshimura H., Kawai K.
- Organizer
  9th International BioMedical Transporters Conference
- Place of Presentation
  Palazzo dei Congressi, Lugano, Switzerland
- Year and Date
  2015-08-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15452
[Presentation] OATP2A1のプロスタグランジンE2動態調節を介した炎症制御に関する研究2015
- Author(s)
  中西猛夫、中村吉伸、島田紘明、御勢智香、黄舒瑩、崎山栞、玉井郁巳
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] FDA承認薬ライブラリを用いたプロスタグランジントランスポーターOATP2A1の阻害剤探索2015
- Author(s)
  加茂俊介、中西猛夫、青谷梨花、御勢智香、玉井郁巳
- Organizer
  日本薬学会北陸支部第127回例会
- Place of Presentation
  富山大学薬学部
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-15K15181
[Presentation] Negative transcriptional regulation of organic anion transporting polypeptide (OATP) 1A2 in androgen receptor (AR)-positive prostate cancer cells2013
- Author(s)
  柳原千泰、中西猛夫、西本朋弘、早川人希、玉井郁巳
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] アンドロゲン受容体陽性前立腺がん細胞の増殖におけるOATPの役割2013
- Author(s)
  中西猛夫、荒川大、玉井郁巳
- Organizer
  日本薬学会医療薬科学部会　次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B12012
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] 前立腺癌細胞におけるトランスポーターを介したアンドロゲン供給調節機構の解明2012
- Author(s)
  西本朋弘、中西猛夫、柳原千泰、荒川大、玉井郁巳
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B12012
- Author(s)
  Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions2012
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] 新しい化学療法を目指したがん細胞における輸送体の機能特性と発現調節に関する研究2012
- Author(s)
  中西猛夫
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀（千葉県）
- Invited
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] In vitro蛍光イメージング(QTLI)法を用いたMRP2機能変動評価－肝代謝を考慮した薬物間相互作用予測への応用－2011
- Author(s)
  池永美穂、中西猛夫、福田元、白坂善之、玉井郁巳
- Organizer
  日本薬学会北支部第123回例会
- Place of Presentation
  金沢大学
- Data Source
  KAKENHI-PROJECT-23659076
[Presentation] VARIABILITY OF FRUIT JUICE-DRUG INTERACTION IN ABSORPTION PROCESS CAUSED BY MULTIPLE BINDING SITES ON OATP2B12011
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] FUNCTIONAL PLEIOTROPY OF OATP2B1 DUE TO MULTIPLE BINDING SITES2011
- Author(s)
  Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Functional Pleiotropy of OATP2B1 Due to Multiple Binding Sites2011
- Author(s)
  Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe International Conference Center/Kobe, Japan
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe International Conference Center（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011
- Author(s)
  白坂善之、Peter Langguth、中西猛夫、玉井郁巳
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀/東京
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] DRUG ABSORPTION AND INTERACTION ON INTESTINAL TRANSPORTERS2011
- Author(s)
  Ikumi Tamai, Yoshiyuki Shirasaka, Takeo Nakanishi
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Upregulation of organic anion transporting polypeptides (OATPs) under the androgen-depletion conditions; A possible molecular mechanism for castration resistance in prostate cancer.2011
- Author(s)
  荒川大、中西猛夫、白坂義之、玉井郁巳
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場（広島）
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011
- Author(s)
  白坂善之、Peter Langguth、中西猛夫、玉井郁巳
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Differential Interaction of Fruit Juices with Transporter-Mediated Absorption of Drugs2011
- Author(s)
  Megumi Shichiri, Yoshiyuki Shirasaka, Takanori Mori, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  The 4th Asian Pacific ISSX Regional Meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-24
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Drug Absorption and Interaction on Intestinal Transporters2011
- Author(s)
  Ikumi Tamai, Yoshiyuki Shirasaka, and Takeo Nakanishi
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Upregulation of organic anion transporting polypeptides (OATPs) under the androgen-depletion conditions; A possible molecular mechanism for castration resistance in prostate cancer.2011
- Author(s)
  荒川大、中西猛夫、白坂義之、玉井郁巳
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590176
[Presentation] Variability of Fruit Juice-Drug Interaction in Absorption Process Caused by Multiple Binding Sites on OATP2B12011
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] ヒト癌細胞株におけるOAT2を介した光線力学療法薬5-アミノレブリン酸の細胞膜輸送2010
- Author(s)
  小川哲郎、中西猛夫、白坂善之、松井裕史、玉井郁巳
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県強度文化会館(徳島市、徳島)
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21890084
[Presentation] Impact of OATP2B1 expression on cell proliferation in ER-positive breast cancer.
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Ikumi Tamai, Takeshi Nagashima and Itsuko Ishii.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-25893224
[Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B1
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Application of quantitative time-laspe imaging(QTL1) for evaluation of MRP2/MRP2-based drug-drug interaction in rat and human hepatocytes.
- Author(s)
  池永美穂、、中西猛夫、福田元、松永憲和、玉井郁巳
- Organizer
  The 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23659076
[Presentation] 新規創薬ターゲットおよびバイオマーカーの確立を目指した乳がんにおけるestrogen前駆体取り込み機構の解明
- Author(s)
  松本准、有吉範高、榊原雅裕、中西猛夫、石井伊都子、山田治美、武田弘志
- Organizer
  第4回国際医療福祉大学学会学術大会
- Place of Presentation
  日本、栃木
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-25893224
[Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B1
- Author(s)
  Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Uptake of an Estrogen Precursor in Estrogen Receptor-Positive Breast Cancer Cells: Focusing on Organic Anion Transporting Polypeptide 2B1
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Yoshiyuki Okubo, Nobumitsu Shiina, Kaoru Fujisaki, Yukio Nakatani, Ikumi Tamai, Takeshi Nagashima, Harumi Yamada, Hiroshi Takeda and Itsuko Ishii
- Organizer
  World congress on Pharmacology
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2015-07-20 – 2015-07-22
- Data Source
  KAKENHI-PROJECT-25893224
[]

1. TAMAI Ikumi (20155237)

# of Collaborated Projects: 8 results

# of Collaborated Products: 51 results
2. AIZAWA Shin (30202443)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SHIRASAKA Yoshiyuki (60453833)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
4. Wakayama Tomohiko (70305100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. KAWAI Keiichi (30204663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. KUNISHIMA Munetaka (10214975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. JUN Matsumoto (60709012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. ISHII Itsuko (00202929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. ARIYOSHI Noritaka (00243957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. NAGASHIMA Takeshi (60292710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SAKAKIBARA Masahiro (70375632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. Nakamichi Noritaka (10401895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKAZAWA Hidehiko (50360813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小林正和 (30444235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 小森久和 (00634180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. 中島美紀 (70266162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Takeuchi Ryota

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. Nakamura Yoshinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
19. Deguchi Yoshiharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. Hinoi Eiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西弘大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 中嶋美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakanishi Takeo 中西 猛夫

NAKANISHI Takeo 中西 猛夫

中西 猛夫 ナカニシ タケオ

Research Projects

Research Products

Co-Researchers

Dysfunction of mitochondrial carriers and steatohepatitisPrincipal Investigator

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An implication of transporter-mediated regulation of brain PG concentration for mental diseasesPrincipal Investigator

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Micro RNA-mediated expressional regulation of transporters

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Study on prostaglandin transporter as a novel target for anti-inflammatory drugsPrincipal Investigator

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Development strategy of tumor diagnostic agent by system upregulated functional biomolecule based on expression analysis of tumor associated transporter

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Role of prostaglandin transporter in pulmonary fibrosis and its therapeutic significancePrincipal Investigator

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Local drug-drug interaction of donepezil with cilostazol at BCRP transporter

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Impact of transporters for uptake of estrogen precursors on progression of breast cancer cells

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Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug Absorption

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New rational for chemotherapy targeting transporters expressed in cancer stem cellsPrincipal Investigator

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Application of Sandwich-cultured hepatocytes for analysis of drug-drug interaction on bile canalicular transporters

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Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acidPrincipal Investigator

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生体膜の物質輸送機構の解明と膜輸送担体を介した薬物送達法の開発Principal Investigator

Principal Investigator

Nakanishi Takeo 中西猛夫

NAKANISHI Takeo 中西猛夫

中西猛夫ナカニシタケオ

[Book] 次世代吸入製剤とデバイスの開発　『肺胞上皮細胞におけるトランスポーターの発現・機能』2018

[Journal Article] Contribution of equilibrative　nucleoside　transporters(s)　to　intestinal　basolateral　and　apical　transport　of　anticancer　trifluridine2018