HANDA Makoto 半田誠

… Alternative Names

半田誠ハンダマコト

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Researcher Number	40129614
Other IDs
Affiliation (based on the past Project Information) *help	2015: 慶応義塾大学, 医学部, 教授 2013 – 2015: 慶應義塾大学, 医学部, 教授 2007: 慶應義塾大学, 医学部, 准教授 2004 – 2007: 慶應義塾大学, 医学部, 助教授 1995 – 1998: 慶應義塾大学, 医学部, 講師 … More 1992: 慶応義塾大学, 医学部, 講師 1988 – 1989: 慶応義塾大学, 医学部, 助手 1987: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Laboratory medicine / Hematology / Emergency medicine / Laboratory animal science / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator GPVI / anti-platelet therapy / gene knockout mice / phospholipase Cγ2 / collagen / platelets / Bruton's tyrosine kinase / phosphoinositide 3-kinase / 分子ノックアウト / LAT … More / 抗血小板療法 / 遺伝子ノックアウトマウス / フォスフォリパーゼγ2 / コラーゲン / 血小板 / Bruton tyrosine kinase / イノシトールリン脂質3キナーゼ … More Except Principal Investigator 血小板 / platelet / 血小板膜糖蛋白 / chronic myelogenous leukemia / signal transduction / tyrosine kinase / thrombopoietin / 血小板膜蛋白 / 輸血 / リポソーム / フォンビルブランド因子 / 内皮細胞 / 抗サイトカイン作用 / 血小板代替物 / 止血作用 / アデノシン / ドラッグデリバリシステム / レーザー誘起衝撃波 / アデノシン作用 / 止血凝固作用 / Blast Lung Injury / gait disturbance / treadmill / born marrow / peripheral arterial disease / 一過性充血 / 病態評価 / 歩様異常 / トレッドミル / 骨髄細胞移植 / 下肢循環不全 / ARTIFICIAL ORGANS / LIPOSOMES / RECOMBINANTS / TRANSFUSION / VON WILLEBRAND FACTOR / PLATELET SUBSTITUTES / PLATELETS / 人工臓器 / リポゾーム / 遺伝子組換え / 情報伝達機構 / トロンボポエチン / Anti-platelet agents / Adhesion molecules / Platelet membrane glycoproteins / Hematocrit / Wall shear rate / Platelet adhesion / 血栓 / ずり速度 / 抗血小板薬 / ヘマトクリット / 接着分子 / 血液の速度 / 血小板粘着 / 血小板粘着異常症 / GPIaーIIa複合体 / コラーゲン不応症 / 血小板活性化 / 細胞骨格 / 【III】a / Gp【II】b / Gp【I】b / cytosheletrl proteins / von willebrand faotor / fibrinagen / GPIIb1IIIa / GPIb / Cone & plate viscometer / Shear-induced platelet aggregrtion / von Willebrand factor / fibrinogen / GpIIbaIIIa / Shear-induced platelet aggregation / 合成CRP / グルココルチコイド受容体 / 核内受容体 / ナノ医学 / 重症感染症 / 活性酸素 / エンドトキシントレランス / 光線力学療法 / 止血ナノ粒子 / ナノシート / ursodepxycolic acid / レスベラトロール / クッパー細胞 / 外科侵襲 / compromised hosts / 異型適合血 / 高カリウム血症 / 輸血後移植片対宿主病 / 放射線照射 / 不規則抗体 / 溶血性副作用 / 溶血反応 / 未交差同型血輸血 / 異型適合血輸血 / 緊急輸血 / 大量出血 / 手術 / 体外診断 / DDS / IX結合体 / 糖蛋白Ib / 血管 / GMP140 / グライコカリシン / 分子マーカー / 巨核球 / コラーゲン粘着 / IIa複合体 / GpIa Less

Management against surgical stress in compromised hosts
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
The Novel Hemostatic and Tissue Protective Treatment Elucidating the Pathophysiology of Blast Lung Injury
- Principal Investigator
  
  HAGISAWA KOHSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
ABO-compatible red blood cell transfusion practices in the operating room and the following hemolytic reactions.
- Principal Investigator
  
  IRITA Kazuo
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
Establishment of a method for quantification of gait disturbance
- Principal Investigator
  
  ORITO Kensuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Azabu University
Anti-platelet thrombus effect of molecular knock out : role of phosphoinositide 3-kinase and its target enzymesPrincipal Investigator
- Principal Investigator
  
  HANDA Makoto
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
血管内皮細胞障害部位のin vivoでの検出と障害修復への新たなアプローチ
- Principal Investigator
  
  池田康夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
CREATION OF A PLATELET SUBSTITUTE USING RECOMBINANT PLATELET MEMBRANE GLYCOPROTEINS
- Principal Investigator
  
  MURATA Mitsuru
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  KEIO UNIVERSITY
Development of mechanical device to continuously guantitute platelet thrunbus formation under flow conditions.
- Principal Investigator
  
  IKEDA Yasuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Keio University School of Medicine
Investigations on the new functions of SHC,Grb2, paxillin, Nck, Csk, PTPase 1C, PTPase 1D.
- Principal Investigator
  
  ODA Atsushi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  School of Medicine, Keio University
血小板分子マーカーの測定に関する研究
- Principal Investigator
  
  渡辺清明
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Keio University
血小板膜糖蛋白GPIaの構造と機能に関する研究
- Principal Investigator
  
  渡辺清明
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
血小板活性化機構における膜糖蛋白と骨格蛋白との相互作用に関する研究
- Principal Investigator
  
  池田康夫 (池田泰夫)
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Keio University
血小板膜糖蛋白GPIaの構造と機能に関する研究
- Principal Investigator
  
  渡辺清明
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University

All 2016 2015 2014 2013 2009 2006 2005 2004

All Journal Article Presentation

[Journal Article] Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling.2016
- Author(s)
  Hagisawa K, Miyawaki H, Kinoshita M, Miyazaki H, Yanagawa R, Doi M, Takeoka S, Suzuki H, Seki S, Saitoh D, Nishida Y, Handa M.
- Journal Title
  
  Critical Care Medicine
  
  Volume: 44 Issue: 9 Pages: e827-e837
- DOI
  10.1097/ccm.0000000000001707
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462843
[Journal Article] Pharmacokinetic properties of single and repeated injection of liposomal platelet substitute in a rat model of red blood cell transfusion-induced dilutional thrombocytopenia.2015
- Author(s)
  Hashimoto M, Taguchi K, Ogaki S, Watanabe H, Kinoshita M, Nishikawa K, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 104 Issue: 11 Pages: 3968-3976
- DOI
  10.1002/jps.24607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Treatment with fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia2015
- Author(s)
  Hagisawa K, Nishikawa K, Yanagawa R, Kinoshita M, Doi M, Suzuki H, Iwaya K, Saitoh D, Seki S, Takeoka S, Handa M, Nishida Y.
- Journal Title
  
  Transfusion.
  
  Volume: 55 Issue: 2 Pages: 314-325
- DOI
  10.1111/trf.12829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25293369
[Journal Article] 人工血小板H12(ADP)リポソームを用いた急性血小板減少病態への止血・救命対策.2013
- Author(s)
  西川可穂子、萩沢康介、柳川錬平、土井麻実、鈴木英紀、齋藤大蔵、阪本敏久、武岡真司、半田誠、木下学
- Journal Title
  
  人工血液
  
  Volume: 21 Pages: 60-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] 手術室における異型輸血に関する実態調査2009
- Author(s)
  入田和男, 稲田英一, 津崎晃一, 稲葉頌一, 半田誠, 紀野修一, 益子邦洋, 久保隆彦, 森田潔
- Journal Title
  
  麻酔 58
  
  Pages: 1045-1054
- NAID
  40016777812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591803
[Journal Article] 麻酔科認定病院の手術室で発生している大量出血とその対応に関する実態調査2009
- Author(s)
  入田和男, 稲田英一, 吉村速, 蕨謙吾, 津崎晃一, 稲葉頌一, 半田誠, 上村知恵, 紀野修一, 益子邦洋, 矢野哲, 亀井良政, 久保隆彦
- Journal Title
  
  麻酔 58
  
  Pages: 109-123
- NAID
  40016420430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591803
[Journal Article] 麻酔科認定病院の手術室で発生している大量出血とその対応に関する実態調査2009
- Author(s)
  入田和男, 稲田英一, 吉村速, 蕨謙吾, 津崎晃一, 稲葉頌一, 半田誠,上村知恵, 紀野修一, 益子邦洋, 矢野哲, 亀井良政, 久保隆彦
- Journal Title
  
  麻酔 58
  
  Pages: 109-123
- NAID
  40016420430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591803
[Journal Article] Analyzing the mechanism of Rap1 activation in platelets : Rap1 activation is related to the release reaction mediated through the collagen receptor GPVI2006
- Author(s)
  Jung SM, Handa M, et al.
- Journal Title
  
  Thromb Res (印刷中)
- Data Source
  KAKENHI-PROJECT-16590963
[Journal Article] Hemostatic Effects of Fibrinogen-γ Chain Dodecapeptide-Conjugated Polymerized Albumin Particles in vitro and in vivo2005
- Author(s)
  Okamura Y, Handa M, et al.
- Journal Title
  
  Transfusion 印刷中
- Data Source
  KAKENHI-PROJECT-16590963
[Journal Article] Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activatio2005
- Author(s)
  Kamata T, Handa M, et al.
- Journal Title
  
  J Biol Chem 280・26
  
  Pages: 24775-24783
- Data Source
  KAKENHI-PROJECT-16590963
[Journal Article] Hemostatic Effects of Fibrinogen-γ Chain Dodecapeptide-Conjugated Polymerized Albumin Particles in vitro and in vivo2005
- Author(s)
  Okaznura Y, Handa M, et al.
- Journal Title
  
  Transfusion 45・7
  
  Pages: 1221-1228
- Data Source
  KAKENHI-PROJECT-16590963
[Journal Article] Phosphoinositide3-kinase independent regulation of Bruton's tyrosine kinase in platelet immunoreceptor signaling2004
- Author(s)
  Watanabe N, Handa M, et al.
- Journal Title
  
  Blood 104・11
- Data Source
  KAKENHI-PROJECT-16590963
[Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014
- Author(s)
  木下学、萩沢康介、西川可穂子、柳川錬平、小野　聡、齋藤大蔵、高瀬凡平、酒井宏水、半田誠、武岡真司、関修司
- Organizer
  第114回日本外科学会定期学術集会　(パネルデスカッション1-3)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 大量出血後の血小板減少状態下での肝外傷出血に対するH12(ADP)リポソーム投与の止血救命効果.2013
- Author(s)
  萩沢康介、木下学、西川可穂子、柳川錬平、土井麻実、武岡真司、齋藤大蔵、関修司、西田育弘、半田誠
- Organizer
  日本血栓止血学会第85回学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 人工血小板H12(ADP)liposomeの止血能評価（臓器損傷後投与による検討）2013
- Author(s)
  土井麻実、木下学、萩沢康介、西川可穂子、柳川錬平、半田誠、池田康夫、武岡真司
- Organizer
  第20回日本血液代替物学会（シンポジウム2-5）
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25293369

1. IKEDA Yasuo (00110883)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 渡辺清明 (20101983)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MURATA Mitsuru (50174305)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. Hagisawa Kosuke (50539244)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. Takeoka Shinji (20222094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. INADA Eiichi (40193552)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. TSUZAKI Koichi (90138107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. MORITA Kiyoshi (40108171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. Kinoshita Manabu (70531391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. Saitoh Daizoh (90531632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
11. ODA Atsushi (50255436)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 川合陽子 (00129727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. IRITA Kazuo (80168541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. Seki Shuhji (80531392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. Tanaka Yuji (50221396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Sakamoto Toshihisa (50178571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. Morimoto Yuji (10449069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Miyazaki Hiromi (30531636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Takahashi Tetsuya (00589905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Nakashima Hiroyuki (10574064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Ono Satoshi (30531355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. Hinoki Akinari (90383257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Nishikawa Kahoko (20345416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
24. YOKOYAMA Kenji (70230662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ORITO Kensuke (70333143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ISHIDA Akaru (80212885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SATOH Shunichi (90502906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SUZUKI Hidenori (30158977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. 千谷晃一 (60179942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 村上博 (60157758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 河合陽子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 土田英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

HANDA Makoto 半田 誠

半田 誠 ハンダ マコト

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Anti-platelet thrombus effect of molecular knock out : role of phosphoinositide 3-kinase and its target enzymesPrincipal Investigator

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[Journal Article] Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling.2016

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[Journal Article] Pharmacokinetic properties of single and repeated injection of liposomal platelet substitute in a rat model of red blood cell transfusion-induced dilutional thrombocytopenia.2015

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[Journal Article] Treatment with fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia2015

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HANDA Makoto 半田誠

半田誠ハンダマコト