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SUGIYAMA AKIRA  杉山 暁

… Alternative Names

Sugiyama Akira  杉山 暁

SUGIYAMA Akira  杉山 暁

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Researcher Number 40562715
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4406-9475
Affiliation (Current) 2025: 星薬科大学, 薬学部, 講師
2025: 東京大学, アイソトープ総合センター, 特任研究員
Affiliation (based on the past Project Information) *help 2018 – 2024: 東京大学, アイソトープ総合センター, 助教
2013 – 2014: 東京大学, アイソトープ総合センター, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Transformative Research Areas, Section (II) / Medium-sized Section 47:Pharmaceutical sciences and related fields / Medium-sized Section 52:General internal medicine and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 90130:Medical systems-related / Tumor therapeutics
Keywords
Principal Investigator
Antibody Drug Conjugate / HER2 / Axially Substituted / photosensitizer / Silicon Phthalocyanine / antibody mimetic / Psyche / Cupid / single domain antibody / antibody mimetics … More / duocarmyucin / nanobody / Yatakemycin / duocarmycin / antibody drug conjugate / DNAアルキル化剤 / duocarmycin SA / Ax-SiPc / VHH / Nanobody / Affibody / Cupid-Psyche / affibody / 抗体ミメティクス / 巻き戻し / デュオカルマイシン / 光増感剤 / VHH抗体 / ドラッグデリバリー … More
Except Principal Investigator
放射性同位元素 / α線放出核種 / ヒト化白血病モデルマウス / 白血病幹細胞 / アスタチン-211 / アスタチン / 胃癌 / 内照射 / 腹膜播種 / ラジオアイソトープ / プレターゲティング法 / アルファ線標的治療(TAT) / 白血病韓細胞 / アスタチン標識抗体 / がん免疫治療 / 短寿命α線核種 / 医療診断 / 薬剤送達システム / 分子プローブ / もつれγ線 / radiotheranostics / セラノスティクス / ドラッグデリバリーシステム / セラノスティックス / PET / ドジメトリー / アビジン / ビオチン / α線 / アイソトープ治療 / プレターゲティング / 抗CD82抗体 / 急性骨髄性白血病 / RI内用療法 / アスタチン-211標識抗体 / 抗hCD82ヒト化キメラmAb / 急性白血病 / アルファ線標的治療 / CD82抗原 / アイソトープ / アルファ線 / 重粒子線 / ドラッグデリバリー / 内照射療法 / At-211 / α線医薬品 / サイクロトロン / α線内用療法 / 自動化 / アルファ線放出核種 / 放射性医薬品 / 自動化装置 / 加速器 / 核医学治療 / 短寿命α線放出核種 / モノマー化 / 低免疫原性 / ストレプトアビジン / シミュレーション / 塩橋 / シミュレ=ション / 分子動力学 / ビオチン結合 / 巻き戻し / モノマー / テトラマー Less
  • Research Projects

    (11 results)
  • Research Products

    (46 results)
  • Co-Researchers

    (31 People)
  •  短寿命α線放出核種によるネオアンチゲン賦活を利用した新規腹膜播種治療の開発

    • Principal Investigator
      野村 幸世
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Hoshi University
  •  α線放出核種と抗体ドラッグデリバリーシステムによる新規放射性医薬品の開発

    • Principal Investigator
      和田 洋一郎
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      The University of Tokyo
  •  薬物送達システムとα線放出核種を組み合わせた革新的な白血病治療法の開発

    • Principal Investigator
      趙 松吉
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Development of radio-theranostics technology and establishment of an international joint research consortium

    • Principal Investigator
      秋光 信佳
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      The University of Tokyo
  •  もつれ光子対放出原子核と分子プローブの創成による生体内化学環境の医療診断

    • Principal Investigator
      重河 優大
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Institute of Physical and Chemical Research
  •  Creation of Next Generation Antibody Drug Conjugate Therapeutics for Advanced CancerPrincipal Investigator

    • Principal Investigator
      Sugiyama Akira
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  Development of an innovative leukemia therapy using alpha-particle-emitting nuclides targeting cancer stem cells

    • Principal Investigator
      ZHAO Songji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Optimization of pretargeted alpha therapy for multiple types of cancer

    • Principal Investigator
      Washiyama Kohshin
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Analysis of the treatment for gastric cancer peritoneal metastasis using hyper-selective short lived alpha-emitting radio isotope

    • Principal Investigator
      Nomura Sachiyo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Tokyo
  •  Development of Robotic Purification and Labeling Technology to Reduce Radiation Exposure in Short-lived Alpha-ray Drug Manufacturing Process

    • Principal Investigator
      wada youichiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90130:Medical systems-related
    • Research Institution
      The University of Tokyo
  •  study of low-immunogenic monomeric streptavidin

    • Principal Investigator
      DOI Hirofumi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Patent Other

  • [Journal Article] pH dependence of perturbed angular correlation in DOTA chelated $$^{111}$$In measured with ring-shape gamma-ray detectors2024

    • Author(s)
      Shimazoe Kenji、Donghwan Kim、Mineo Tomoko、Sato Takeshi、Ohta Seiichi、Tatsumi Toshifumi、Sugiyama Akira、Yamatsugu Kenzo、Nomura Sachiyo、Terabayashi Ryohei、Tomita Hideki、Sonoda Tetsu、Shigekawa Yudai、Yokokita Takuya、Uenomachi Mizuki
    • Journal Title

      Interactions

      Volume: 245 Issue: 1 Pages: 22-22

    • DOI

      10.1007/s10751-024-01864-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18223, KAKENHI-PROJECT-20KK0174, KAKENHI-ORGANIZER-22H05017, KAKENHI-PLANNED-22H05018, KAKENHI-ORGANIZER-22H05021, KAKENHI-PLANNED-22H05022, KAKENHI-PLANNED-22H05024, KAKENHI-PROJECT-22H04961
  • [Journal Article] Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin2024

    • Author(s)
      Sakata Juri、Tatsumi Toshifumi、Sugiyama Akira, et al.
    • Journal Title

      Protein Expression and Purification

      Volume: 214 Pages: 106375-106375

    • DOI

      10.1016/j.pep.2023.106375

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15217, KAKENHI-PROJECT-22KJ0538, KAKENHI-PROJECT-20KK0174, KAKENHI-ORGANIZER-22H05017, KAKENHI-PLANNED-22H05018, KAKENHI-PLANNED-22H05024, KAKENHI-PROJECT-19H01032, KAKENHI-PROJECT-21H02601, KAKENHI-PROJECT-21H02779
  • [Journal Article] Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system2022

    • Author(s)
      Yamatsugu Kenzo、Katoh Hiroto、Yamashita Takefumi、Takahashi Kazuki、Aki Sho、Tatsumi Toshifumi、Kaneko Yudai、Kawamura Takeshi、Miura Mai、Ishii Masazumi、Ohkubo Kei、Osawa Tsuyoshi、Kodama Tatsuhiko、Ishikawa Shumpei、Kanai Motomu、Sugiyama Akira
    • Journal Title

      Protein Expression and Purification

      Volume: 192 Pages: 106043-106043

    • DOI

      10.1016/j.pep.2021.106043

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03510, KAKENHI-PROJECT-21H02779, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H02779, KAKENHI-PROJECT-20K07260, KAKENHI-PROJECT-21K19399, KAKENHI-PUBLICLY-20H04819
  • [Journal Article] Nucleic acid-triggered tumoral immunity propagates pH‐selective therapeutic antibodies through tumor‐driven epitope spreading2022

    • Author(s)
      Furuya G, Katoh H, Atsumi S, Hashimoto I, Komura D, Hatanaka R, Senga S, Hayashi S, Akita S, Matsumura H, Miura A, Mita H, Nakakido M, Nagatoishi S, Sugiyama A, Suzuki R, Konishi H, Yamamoto A, Abe H, Hiraoka N, Aoki K, Kato Y, Seto Y, Yoshimura C, Miyadera K, Tsumoto K, Ushiku T, Ishikawa S
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 321-338

    • DOI

      10.1111/cas.15596

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-22K09929, KAKENHI-PLANNED-22H05024, KAKENHI-PROJECT-19H01032, KAKENHI-PROJECT-20H02531
  • [Journal Article] The serological diversity of serum IgG/IgA/IgM against SARS-CoV-2 nucleoprotein, spike, and receptor-binding domain and neutralizing antibodies in patients with COVID-19 in Japan2022

    • Author(s)
      Kaneko Y, Sugiyama A, Tanaka T, Fukui K, Taguchi A, Tatsuno K, Nakayama A, Koga K, Kishi Y, Daming W, Qian C, Xia F, He F, Zheng L, Yu Y, Wada You, Wada Yos, Kodama T, Kawamura T
    • Journal Title

      Health Science reports

      Volume: 5(3) Issue: 3

    • DOI

      10.1002/hsr2.572

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0174, KAKENHI-PLANNED-22H05024
  • [Journal Article] Pathological complete remission of relapsed tumor by photo‐activating antibody-mimetic drug conjugate treatment2022

    • Author(s)
      Kaneko Yudai、Yamatsugu Kenzo、Yamashita Takefumi、Takahashi Kazuki、Tanaka Toshiya、Aki Sho、Tatsumi Toshifumi、Kawamura Takeshi、Miura Mai、Ishii Masazumi、Ohkubo Kei、Osawa Tsuyoshi、Kodama Tatsuhiko、Ishikawa Shumpei、Tsukagoshi Masanobu、Chansler Michael、Sugiyama Akira、Kanai Motomu、Katoh Hiroto
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 12 Pages: 4350-4362

    • DOI

      10.1111/cas.15565

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05024, KAKENHI-PROJECT-19H01032, KAKENHI-PROJECT-19H03496, KAKENHI-PROJECT-20H02779, KAKENHI-PROJECT-21H02779, KAKENHI-PROJECT-20K07260, KAKENHI-PROJECT-21K19399, KAKENHI-PUBLICLY-20H04819, KAKENHI-ORGANIZER-22H05017
  • [Journal Article] Axially-substituted silicon phthalocyanine payloads for antibody-drug conjugates2021

    • Author(s)
      Takahashi Kazuki、Sugiyama Akira、Ohkubo Kei、Tatsumi Toshifumi、Kodama Tatsuhiko、Yamatsugu Kenzo、Kanai Motomu
    • Journal Title

      Synlett

      Volume: 32 Issue: 11 Pages: 1098-1103

    • DOI

      10.1055/a-1503-6425

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-20H04819, KAKENHI-PROJECT-19H03510, KAKENHI-PROJECT-20H02779
  • [Journal Article] Cupid and Psyche system for the diagnosis and treatment of advanced cancer2019

    • Author(s)
      Sugiyama A, Kawamura T, Tanaka T, Doi H, Yamashita T, Shinoda K, Fujitani H, Yamatsugu K, Shimizu Y, Tatsumi T, Takahashi K, Kanai M, Mizohata E, Kawato T, Doi T, Inoue T, Kodama T.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 95 Issue: 10 Pages: 602-611

    • DOI

      10.2183/pjab.95.041

    • NAID

      130007760701

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2019-12-11
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22496, KAKENHI-PROJECT-18H03548
  • [Patent] VHH抗体とストレプトアビジン変異体との融合タンパク質2023

    • Inventor(s)
      杉山 暁、田中 十志也、児玉 龍彦、その他
    • Industrial Property Rights Holder
      国立大学法人東京大学、国立大学法人東北大学、その他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-053049
    • Filing Date
      2023
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Patent] ビオチン改変二量体とその診断および治療的利用2020

    • Inventor(s)
      杉山暁(他11名)
    • Industrial Property Rights Holder
      東京大学、福島県立医科大学および他1法人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18H03548
  • [Presentation] RADIOIMMUNOTHERAPY OF AT-211-LABELED ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR 4 (FGFR4) ANTIBODY IS A PROMISING TREATMENT FOR PERITONEAL DISSEMINATION OF GASTRIC CANCER: IN IMMUNOCOMPETENT MICE STUDY2023

    • Author(s)
      Komei Kuge, Hiroki Masuda, Wan-Ying Du, Tomohiko Yasuda, Akira Sugiyama, Hiromitsu Haba, Toshifumi Tatsumi, Nobuyoshi Akimitsu, Yoshitaka Kumakura, Hiroshi Yoshida, Yasuyuki Seto, Youichiro Wada, Sachiyo Nomura
    • Organizer
      DDW2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] Pretargeted alpha radioimmunotherapy for the treatment of gastric cancer using low-immunogenic mutated streptavidin and 211At labeled modified bis-iminobiotin2023

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      12th International Symposium on Targeted Alpha Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Antibody Mimetic Drug Conjugateによるがん治療法開発2023

    • Author(s)
      坂田 樹理、巽 俊文、金井求、児玉龍彦、徳山英利、山次健三、杉山 暁
    • Organizer
      日本抗体学会
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] Antibody Mimetic Drug Conjugate によるがん治療法開発2023

    • Author(s)
      杉山 暁,巽 俊文,金井求,児玉龍彦,田中十志也,川村猛,徳山英利,坂田樹里,山次健三
    • Organizer
      第2回日本抗体学会
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] Pretargeted alpha radioimmunotherapy for gastric cancer using low-immunogenic mutated streptavidin and 211At labeled modified bis-iminobiotin2023

    • Author(s)
      K. Washiyama, A. Sugiyama, S. Zhao, T. Tatsumi, M. Aoki, K. Yamatsugu, K. Nishijima, N. Ukon, S. Shimoyama, T. Joho, N. Oriuchi, M. Kanai, K. Takahashi, T. Kodama
    • Organizer
      12th Targeted Alpha Therapy International Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] 胃癌腹膜播種モデルマウスを用いた腹膜播種に対する211At標識抗FGFR4抗体による放射線免疫療法の検討2022

    • Author(s)
      久下 恒明、杜 婉瑩、保田 智彦、杉山 暁、羽場 宏光、巽 俊文、秋光 信佳、熊倉 嘉貴、吉田 寛、瀬戸 泰之、和田 洋一郎、野村 幸世
    • Organizer
      第81回日本癌学会総会
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] Synthesis and Astatine Labeling of a bis-iminobiotin derivative with enhanced plasma stability2022

    • Author(s)
      K. Washiyama, A. Sugiyama, S. Zhao, T. Tatsumi, M. Aoki, K. Yamatsugu, K. Nishijima, N. Ukon, S. Shimoyama, T. Joho, N. Oriuchi, M. Kanai, K. Takahashi, T. Kodama
    • Organizer
      International Symposium On Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] Synthesis of an 211At labelled bis-iminobiotin derivativewith enhanced plasma stability2022

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      2022 JSNM Annual Meeting
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 改変ストレプトアビジン-イミノビオチンを用いた抗体ミメティクス薬物複合体と近赤外治療法への展開2022

    • Author(s)
      山次健三、高橋和希、加藤洋人、山下雄史、安藝翔、 巽俊文、 金子雄大、川村猛、三浦麻衣、 石井正純、 大久保敬、 大澤 毅、 児玉龍彦、 石川俊平、杉山 暁 、金井求
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] 低免疫原性ストレプトアビジン変異体と改変ビオチンを用いるプレターゲティングシステムの開発2022

    • Author(s)
      T. Tatsumi, K. Washiyama, A. Sugiyama, S. Zhao, M. Aoki, K. Yamatsugu, K. Nishijima, N. Ukon, S. Shimoyama, T. Joho, N. Oriuchi, M. Kanai, K. Takahashi, T. Kodama
    • Organizer
      日本放射化学会第66回討論会(2022)
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] 胃癌腹膜播種モデルマウスを用いた腹膜播種に対する211At標識抗FGFR4抗体による放射線免疫療法2022

    • Author(s)
      久下恒明、杜 婉瑩、増田寛喜、保田智彦、杉山暁、巽俊文、羽場宏光、瀬戸泰之、吉田寛、秋光信佳、熊倉嘉貴、和田洋一郎、野村幸世
    • Organizer
      第33回日本消化器癌発生学会総会
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] 改変ストレプトアビジン-イミノビオチンを用いた抗体ミメティクス薬物複合体と近赤外治療法への展開2022

    • Author(s)
      山次健三、高橋和希、加藤洋人、山下雄史、安藝翔、 巽俊文、 金子雄大、川村猛、三浦麻衣、 石井正純、 大久保敬、 大澤 毅、 児玉龍彦、 石川俊平、杉山 暁 、金井求
    • Organizer
      日本ケミカルバイオロジー学会 第16回年会
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] Synthesis and evaluation of 211At-labeled bis-iminobiotin for pretargeted alpha radioimmunotherapy2022

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      2022 SNMMI Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 胃癌腹膜播種モデルマウスを用いた211At標識抗FGFR4抗体による放射線免疫療法の検討2022

    • Author(s)
      久下恒明,増田寛喜,杜婉瑩,保田智彦,杉山暁,羽場宏光,巽俊文,秋光信佳,熊倉嘉貴,吉田寛,瀬戸泰之,和田洋一郎,野村幸世
    • Organizer
      日本放射化学会第66回討論会(2022)
    • Data Source
      KAKENHI-PLANNED-22H05024
  • [Presentation] 改変ストレプトアビジン―イミノビオチン薬物送達システムを用いた近赤外治療法の開発(Near-infrared Phototherapy Using Modified Streptavidin-iminobiotin drug delivery system.)2022

    • Author(s)
      山次 健三, 加藤 洋人, 山下 雄史,安藝 翔3, 巽 俊文, 高橋 和希, 金子雄大, 三浦 麻衣, 石井 正純, 大久保 敬, 大澤 毅, 児玉 龍彦, 石川俊平, 金井 求, 杉山 暁
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] Targeted delivery of 211-At with low immunogenic mutant streptavidin-bisiminobiotin pre-targeting therapy2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Yohei Shimizu, Akira Sugiyama, Songji Zhao, Ken-ichi Nishijima, Naoyuki Ukon, Noboru Oriuchi, Kazuhiro Takahashi, Kohshin Washiyama, Tatsuhiko Kodama,Motomu Kanai
    • Organizer
      AIMECS 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] Targeted delivery of 211-At with low immunogenic mutant streptavidinbisiminobiotin pre-targeting therapy2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Yohei Shimizu, Akira Sugiyama, Songji Zhao, Ken-ichi Nishijima, Naoyuki Ukon, Noboru Oriuchi, Kazuhiro Takahashi, Kohshin Washiyama, Tatsuhiko Kodama,Motomu Kanai)
    • Organizer
      AIMECS 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03510
  • [Presentation] Targeted delivery of 211At with low immunogenic mutant streptavidin bisiminobiotin pre-targeting system2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Akira Sugiyama, Songji Zhao, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Fengying Gao, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      Pacifichem2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03510
  • [Presentation] 改変ストレプトアビジン―イミノビオチン薬物送達システムを用いた近赤外治療法の開発2021

    • Author(s)
      高橋 和希 山次 健三, 加藤 洋人, 山下 雄史,安藝 翔3, 巽 俊文, 金子雄 大, 三浦 麻衣, 石井 正純, 大久保 敬, 大澤 毅, 児玉 龍彦, 石川俊平, 金井 求, 杉山 暁)
    • Organizer
      日本薬学会第142回年会
    • Data Source
      KAKENHI-PROJECT-19H03510
  • [Presentation] Targeted delivery of At-211 with low immunogenic mutant streptavidin-bisiminobiotin pre-targeting system2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Akira Sugiyama, Songji Zhao, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Fengying Gao, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      Pacifichem 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02779
  • [Presentation] Targeted delivery of 211At with low immunogenic mutant streptavidin-bisiminobiotin pre-targeting system2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Akira Sugiyama, Songji Zhao, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Fengying Gao, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] イミノビオチン誘導体の合成とアスタチン標識の検討2020

    • Author(s)
      粟生木美穂, 巽俊文, 西嶋剣一, 山次健三, 城寶大輝, 趙松吉, 杉山暁, 児玉龍彦, 高橋和弘, 金井求, 鷲山幸信
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] プレターゲティングへの応用を目指した211At標識改変イミノビオチンの体内分布測定2020

    • Author(s)
      鷲山幸信, 巽俊文, 杉山暁, 粟生木美穂, 譚成博, 下山彩希, 山次健三, 金井求, 児玉龍彦, 趙松吉, 高橋和弘
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 進行癌におけるCupidと211At標識Psyche-Bを用いたプレターゲティング法の治療効果評価2020

    • Author(s)
      趙松吉, 右近直之, 織内昇, 高峰英, 下山彩希, 高橋和弘, 巽俊文, 山次健三, 金井求, 杉山暁, 児玉龍彦
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Development of a pre-targeting strategy of low-immunogenic mutated streptavidin with 211At labeled modified biotin for advanced cancer treatment2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      SNMMI 2020 Annual Meeting - Virtual Edition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Search for the optimal bis-iminobiotin for the pretargeting strategy using a mutated low immunogenic streptavidin2020

    • Author(s)
      K. Washiyama, T. Tatsumi, S. Zhao, A. Sugiyama, M. Aoki, K. Yamatsugu, N. Ukon, K. Nishijima, S. Shimoyama, C. Tan, T. Joho, N. Oriuchi, M. Kanai, K. Takahashi, T. Kodama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 211At標識イミノビオチンを用いたプリターゲティング法の最適化 投与間隔による薬物動態評価2020

    • Author(s)
      右近直之, 鷲山幸信, 杉山暁, 巽俊文, 山次健三, 下山彩希, 織内昇, 金井求, 児玉龍彦, 高橋和弘, 趙松吉
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Biodistribution and dosimetry studies for the optimization of pre-targeted radionuclide therapy using 211At-labeled modified biotin2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 低免疫原性を持つストレプトアビジンとRI標識イミノビオチンを用いたプ レターゲティング法の開発2020

    • Author(s)
      杉山暁、山次健三、巽俊文、鷲山幸信、金井求、児玉龍彦、清水洋平、溝端栄一、井上豪
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] α放射体211At標識イミノビオチンの作成と安定性評価2020

    • Author(s)
      鷲山幸信、粟生木美穂、巽俊文、山次健三、杉山暁、西嶋剣一、城寶大輝、高峰英、趙松吉、金井求、児玉龍彦、高橋和弘
    • Organizer
      日本放射化学会第64回討論会(2020)
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 進行がん治療を指向した低免疫原性ストレプトアビジン変異体と 211At標識イミノビオチンを用いるプレターゲティングシステムの開発2020

    • Author(s)
      巽俊文, 山次健三, 清水洋平, 杉山暁, 趙松吉, 粟生木美穂, 西嶋剣一, 右近直之, 高橋和弘, 児玉龍彦, 鷲山幸信, 金井求
    • Organizer
      反応と合成の進歩2020特別企画シンポジウム|
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] α放射体211Atを用いたプレターゲティング法による進行がんの治療2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Kenzo Yamatsugu, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Naoyuki Ukon, Saki Shimoyama, Ken-ichi Nishijima, Chengbo Tan, Taiki Joho, Fengying Gao, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      日本放射線影響学会第63回大会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 低免疫原性を持つストレプトアビジンとRI標識イミノビオチンを用いたプレターゲティング法の開発2020

    • Author(s)
      杉山暁
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H03548
  • [Presentation] Evaluation of therapeutic effect of the targeted alpha therapy using Cupid-211At-labeled Psyche-B pretargeting system in a human gastric cancer cell xenograft2020

    • Author(s)
      Songji Zhao, Akira Sugiyama, Naoyuki Ukon, Saki Shimoyama, Toshifumi Tatsumi, Miho Aoki, Fengying Gao, Kenzo Yamatsugu, Ken-ichi Nishijima, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • []

  • []

  • 1.  Nomura Sachiyo (70301819)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  羽場 宏光 (60360624)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  秋光 信佳 (40294962)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  wada youichiro (10322033)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  ZHAO Songji (80374239)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 6.  Washiyama Kohshin (80313675)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 7.  織内 昇 (40292586)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  熊倉 嘉貴 (90517773)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  高橋 和弘 (20370257)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 10.  右近 直之 (70792985)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 11.  巽 俊文 (80868232)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 22 results
  • 12.  池添 隆之 (80294833)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  西嶋 剣一 (60364254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  粟生木 美穂 (10783227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 15.  DOI Hirofumi (80403335)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  小泉 憲裕 (10396765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  小木曽 公尚 (30379549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  久下 裕司 (70321958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  山下 雄史 (50615622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  横山 明彦 (80230655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  田中 十志也 (20396930)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  坂田 樹理 (20772700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 23.  張 宰雄 (50964764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  重河 優大 (60845626)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  横北 卓也 (10802655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  山下 篤 (90372797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  崔 正国 (90572115)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  大久保 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  上ノ町 水紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  加藤 靖正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  鈴木 厚子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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