IDE Toshinori 井出利憲

… Alternative Names

井手利憲イデトシノリ

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Researcher Number	60012746
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Affiliation (based on the past Project Information) *help	2006 – 2007: 広島国際大学, 薬学部, 教授 2005: Hiroshima University, Department of Cellular & Molecular Biology, Professor, 医歯薬総合研究科, 教授 2004: 国立大学法人広島大学, 大学院・医歯薬総合研究科, 教授 2004: Graduate School of Biomedical Sciences, Professor, 医歯薬学総合研究科, 教授 2002 – 2004: Hiroshima University, Graduated School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 … More 2003: 広島大学, 大学院・医師薬総合研究所, 教授 1987 – 2001: Hiroshima University School of Medicine, 医学部, 教授 1986: 広島大, 医学部, 助教授 1985: 広島大学, 医, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy / Biological Sciences Except Principal Investigator Chemical pharmacy / Digestive surgery / Biological pharmacy / Cell biology
Keywords	Principal Investigator テロメア / テロメラーゼ / telomerase / 細胞不死化 / telomere / 細胞老化 / hTERT / 細胞周期 / 培養細胞 / 温度感受性変異株 … More / 細胞分裂寿命 / 分裂寿命 / 体細胞遺伝学 / 細胞増殖 / 癌診断 / 不死化 / 増殖調節 / 肝実質細胞 / 血管内皮細胞 / proliferative life span / ECTR / immortalization / アストロサイト / 繊維芽細胞 / 遺伝子発現 / プロテオーム解析 / TERT / cancer diagnosis / 細胞癌化 / cellular senescence / ヒト細胞 / T抗原 / cDNAライブラリー / 線維芽細胞 / 哺乳類細胞 / 突然変異株 / がんウィルス / オンコジン / 温度感受性変異 / 増殖誘導 / プロテオーム / 変異株 / oncogene / tumor viruses / cell culture / somatic cell genetics / mutants / growth regulation / Cell cycle / 温度感受性 / 細胞培養 / celllar senescence / immortal cells / cell life-span / stem cells / 間葉系幹細胞 / ヒト培養細胞 / 不死化細胞 / 幹細胞 / fibroblasts / gene expression / proteome / ウイルスベクター / 乳腺上皮細胞 / hepatocyte / astrocyte / endothelial cell / human somatic cell / ヒト正常体細胞 / immortalization of cell / telomere-binding proteins / extra chromosomal telomere repeats / telomere DNA / テロメアタンパク質 / 染色体外テロメア配列 / テロメアDNA / growth induction / culture shock / transformation / signal transduction / proliferative lifespan / 骨芽細胞 / 分裂寿命延長 / 癌細胞 / 老化 / バイオテクノロジー / 細胞・組織 / 遺伝子 / 癌 / カルチャーショック / トランスフォーメーション / 細胞内シグナル伝達 / Immortalization / SV40 T-antigen / SV40-T抗原 / cellular immortality / cellular lifespan / 癌組織 / テロメラーゼ発現 / hTRT / テロメラーゼcDNA / differential screening / cDNA library / immortality gene / senescence gene / cell immortality / cDNA / ディファレンシャルスクリーニング / ディファレンシャルスクリーニング / 不死化遺伝子 / 老化遺伝子 / Growth repression / Interferon / Cytokines / CDNA library / Senescence / Fibroblasts / ヒト線維芽細胞 / サイトカン / 増殖抑制 / インターフェロン / サイトカイン / Bovine brain / Cell surface material / Cell growth inhibition / 細胞表層分子 / 増殖抑制因子 / 核タンパク質 / シグナルトランスダクション / 細胞複製 / 遺伝子クローニング / GO期 / プロテアソーム / タンパク質分解 / G1チェックポイント / DNA障害 / 癌早期診断 / 診断マーカー / テロメラーゼ複合体 / テロメラーゼ遺伝子 / HPA法 / TRAP / 制癌剤 / 癌診断法 / 染色体外テロメア断片DNA / テロメア維持機構 / 増殖変異株 / cdk2 / サイクリン / Rポイント / シグナル伝達系 … More Except Principal Investigator 細胞周期 / 温度感受性変異株 / 癌抑制遺伝子 / RB蛋白質 / Premna subscandens / テロメラーゼ / 増殖因子 / サイクリン / 核内癌遺伝子 / acteoside / M cell / collagen / アクテオサイド / M細胞 / コラーゲン / 不死化 / TRAP / テロメアーゼ / テロメア / HGF / シグナル伝達 / 癌と間質との相互作用 / がん抑制遺伝子 / がん遺伝子 / TGFβ / ユビキチン / 癌遺伝子 / cdc2キナ-ゼ / 細胞分化 / cdc2キナーゼ / ECA chip / real time PCR / hTERT / HPA / pancreatic juice / Pancreatic cancer / p53 / RAS / HPA-TRAP / ECAチップ / 膵癌 / Immortalization / Telomerase / Aging / Telomere / 老化 / flavonoid / Alangium platanifolium / ヤエヤマハマクサギ / フラボノイド / モミジウリノキ / アクテオシド / ヤエヤマハマクサビ / phenylethanoid / liver fibrosis / クマツヅラ科 / フェニルエタノイド / 肝線維化 / RADIATION HYBRID / GENE MAPPING / CHROMOSOME 7 / GENE / IMMORTALIZATION / SENESCENCE / シグナル伝達系 / cGMP-依存プロテインキナーゼ / D群不死化細胞株 / 不死化細胞 / 情報伝達 / 細胞老化遺伝子 / 細部不死化 / 細部老化 / 遺伝子マッピング / 7番染色体 / 遺伝子クローン化 / 放射線雑種細胞 / 細胞老化 / DNA複製起点 / DnaA蛋白質 / N-myc蛋白質 / ホルボールエステル / コフィリン / イノシトール輸送 / myc / fos / がんウイルス / ゲノムライブラリー / cDNAライブラリー / 細胞変異株 / 阻害物質 / オトギリソウ科 / テリハボク / 癌 / Hrs / アポトーシス / インターフェロン / p115 / c-met / 増殖因子レセプター / TGFbeta / DNAポリメラーゼalpha / ERMファミリー / 細胞接着分子 / チロシンキナーゼ受容体 / サイトカイン / ^<cdc2>キナーゼ / RV蛋白質 / 細胞のトランスフォ-メ-ション / CDNAライブラリィ / 転写制御因子 / ヒストンデアセチラ-ゼ / cーmosキナ-ゼ / TGFーβ / ホスファチジルセリン / 形質導入ベクタ- / cDNAライブラリィ / 遺伝子発現制御 / 染色体分配 / 発現の調節 / 遺伝子組換え / 減数分裂 / DNAメチル化 / クロマチン凝縮 / 細胞複製 / 細胞のトランスフォーメーション / 遺伝子のクローニング / 転写制御 / アンチ癌遺伝子 / トリコスタチン / DNA複製開始点 / cーmos蛋白質 / デストリン Less

Role of telomerase on stem cellsPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima International University
Development of genetic diagnosis system for pancreatic cancer using modified telomeric repeat amplification protocols and electrochemical array chip
- Principal Investigator
  
  MIZUMOTO Kazuhiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYUSHU UNIVERSITY
Possible new function of telomerasePrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
DNA障害時に急速に分解するタンパク質群の役割Principal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
Immortalization of human somatic cells ; possible stem cells.Principal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Telomerase and telomere maintenance and cell immortalityPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Analysis and clinical application of telomerase and telomere functionsPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
Do telomere regulate in vivo aging?
- Principal Investigator
  
  TAHARA Hidetoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
テロメラーゼ機能・テロメア維持機構の解明とその臨床応用Principal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
テロメラーゼ酵素活性を阻害する植物成分検索法確立の可能性
- Principal Investigator
  
  OTSUKA Hideaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hiroshima University
Mechanisms of cellular immortalization and, carcinogenesisPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
SEARCH AND POSSIBLE USAGE OF FUNCTIONAL MOLECULES USING COLLAGEN-FORMING CULTURED CELLS
- Principal Investigator
  
  OTSUKA Hideaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hiroshima University
Cloning and clinical application of telomerase cDNAPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
細胞増殖因子からみた癌細胞と間質細胞との相互作用-その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
GO期特異的変異株を相補するcDNAのクローニングPrincipal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
Screening for biologically active compounds which influence the formation of collagen fibers using culltured liver M cells
- Principal Investigator
  
  OTSUKA Hideaki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
cDNA cloning of cellular aging and cellular senescencePrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
CHARACTERIZATION OF SENESCENCE GENES IN HUMAN CELLS
- Principal Investigator
  
  AYUSAWA Dai
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  KIHARA INSTITUTE FOR BIOLOGICAL RESEARCH
  The University of Tokyo
細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-
- Principal Investigator
  
  田原榮一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
細胞周期の制御機構における癌遺伝子・癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
G1/S境界移行に関わる変異株細胞の解析Principal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
Cloning of genes which regulate mortalityPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
細胞増殖,分化の制御における核内癌遺伝子の機能
- Principal Investigator
  
  小田鈎一郎
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Science
細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
増殖誘導時にのみ機能する細胞遺伝子群の探索と解析Principal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
細胞増殖、分化の制御における核内癌遺伝子の機能
- Principal Investigator
  
  小田鈎一郎
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Science
細胞複製と遺伝子発現の相関
- Principal Investigator
  
  堀田康雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
細胞増殖,分化の制御における核内癌遺伝子の機能
- Principal Investigator
  
  小田鈎一郎
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo University of Science
Purification of Growth Inhibitory Material from Bovine BrainPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
細胞核内に局在するがん遺伝子産物の機能
- Principal Investigator
  
  山口宣生
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
哺乳類細胞の細胞の細胞複製調節に関与する遺伝子群の遺伝学的解析Principal Investigator
- Principal Investigator
  
  井手利憲
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hiroshima University
GoーG1移行期にのみ働らく遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
Isolation and analysis of temperature-sensitive mutants defective in growth regulationPrincipal Investigator
- Principal Investigator
  
  IDE Toshinori
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HIROSHIMA UNIVERSITY
増殖誘導時にのみ機能する細胞遺伝子群の探索Principal Investigator
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University

All 2007 2006

All Journal Article Presentation Book

[Book] 細胞の老化2006
- Author(s)
  井出利憲
- Total Pages
  179
- Publisher
  サイエンス社
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] Telomerase activation induces elongation of the telomeric single-strand overhang, but does not prevent chromosome aberrations in human vascular endothelial cells.2007
- Author(s)
  井出利憲ほか5名
- Journal Title
  
  Biochem.Biophys.Res.Commun. 353
  
  Pages: 926-932
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞老化機構とヒトの老化2007
- Author(s)
  井出利憲
- Journal Title
  
  再生医療 6
  
  Pages: 336-343
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] Simulated microgravity facilitates human mesenchymal stem cell proliferation and chondrocyte differentiation after transplantation.2007
- Author(s)
  井出利憲ほか10名
- Journal Title
  
  Stem Cells and Development (印刷中)
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞老化---細胞老化は個体老化の原因である2006
- Author(s)
  井出利憲
- Journal Title
  
  医学の歩み 217
  
  Pages: 787-762
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3'telomeric overhang in cancer cells2006
- Author(s)
  Hidetoshi Tahara
- Journal Title
  
  Oncogene 25
  
  Pages: 1955-1966
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞増殖のしくみ-細胞周期,癌遺伝子,細胞老化-2006
- Author(s)
  井出利憲
- Journal Title
  
  薬学雑誌 126
  
  Pages: 1087-1115
- NAID
  110004857373
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells2006
- Author(s)
  Hidetoshi Tahara
- Journal Title
  
  Oncogene 25
  
  Pages: 1955-1966
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞老化-細胞老化は個体老化の原因である2006
- Author(s)
  井出利憲
- Journal Title
  
  医学の歩み 217
  
  Pages: 757-762
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞増殖のしくみ-細胞周期,癌遺伝子,細胞老化-2006
- Author(s)
  井出利憲
- Journal Title
  
  広島医学雑誌 54
  
  Pages: 1-43
- NAID
  110004857373
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.2006
- Author(s)
  井出利憲ほか6名
- Journal Title
  
  Oncogene 25
  
  Pages: 1955-1966
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 内因性細胞老化(老化時計)2006
- Author(s)
  井出利憲
- Journal Title
  
  肝, 胆, 膵 55
  
  Pages: 13-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] 細胞増殖のしくみ--細胞周期、癌遺伝子、細胞老化2006
- Author(s)
  井出利憲
- Journal Title
  
  薬学雑誌 126
  
  Pages: 1087-1115
- NAID
  110004857373
- Data Source
  KAKENHI-PROJECT-18590058
[Journal Article] Mitogenic signalling and the p16^<ink4a>-Rb pathway cooperate to enforce irreversible cellular senescence through activating ROS/PKC-delta signalling pathway.2006
- Author(s)
  井出利憲ほか9名
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Data Source
  KAKENHI-PROJECT-18590058
[Presentation] Development of anti-cancer drugs targeted on telomere G-tail2006
- Author(s)
  Hidetoshi Tahara
- Organizer
  Sixty-fifth Annual Meeting of the Japanese Canser Association
- Place of Presentation
  Pacifico Yokohama, Yokohama, Kanagawa, Japan
- Year and Date
  2006-09-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590058

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IDE Toshinori 井出 利憲

井手 利憲 イデ トシノリ

Research Projects

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Co-Researchers

Role of telomerase on stem cellsPrincipal Investigator

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Possible new function of telomerasePrincipal Investigator

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DNA障害時に急速に分解するタンパク質群の役割Principal Investigator

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Immortalization of human somatic cells ; possible stem cells.Principal Investigator

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Telomerase and telomere maintenance and cell immortalityPrincipal Investigator

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Analysis and clinical application of telomerase and telomere functionsPrincipal Investigator

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テロメラーゼ機能・テロメア維持機構の解明とその臨床応用Principal Investigator

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Mechanisms of cellular immortalization and, carcinogenesisPrincipal Investigator

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Cloning and clinical application of telomerase cDNAPrincipal Investigator

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IDE Toshinori 井出利憲

井手利憲イデトシノリ