Ema Masatsugu 依馬正次

… Alternative Names

EMA Masatsugu 依馬正次

依馬正次エママサツグ

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Researcher Number	60359578
Other IDs	https://orcid.org/0000-0003-0645-6183
External Links
Affiliation (Current)	2025: 滋賀医科大学, 動物生命科学研究センター, 教授
Affiliation (based on the past Project Information) *help	2013 – 2025: 滋賀医科大学, 動物生命科学研究センター, 教授 2014 – 2016: 滋賀医科大学, 学内共同利用施設等, 教授 2015: 滋賀医科大学, 動物生命科学研究センター幹細胞・ヒト疾患モデル研究分野, 教授 2012: 筑波大学, 医学医療系, 准教授 2011: 筑波大学, 医学医療系, 講師 … More 2008 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 講師 2008: 筑波大学, 大学院・人間総合科学研究科, 教授 2007: 筑波大, 人間総合科学研究科, 講師 2006: 筑波大学, 大学院人間総合科学研究科, 講師 2005: 筑波大学, 大学院・人間総合科学研究科, 講師 2003: 筑波大学, 基礎医学系, 講師 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Laboratory animal science / General medical chemistry / Laboratory animal science Except Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Cerebral neurosurgery … More / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 42020:Veterinary medical science-related / Basic Section 43050:Genome biology-related / Basic Section 56010:Neurosurgery-related / General medical chemistry / Applied health science / Neurosurgery / Pathological medical chemistry / Laboratory animal science Less
Keywords	Principal Investigator 血管新生 / 血管内皮細胞 / 胚盤胞 / 発生 / 再生 / 転写因子 / 循環器 / 霊長類 / 不妊 / 内部細胞塊 … More / 胎盤 / 非ヒト霊長類 / カニクイザル / 動物 / 神経 / 再生医学 / 発生・分化 / ヒト胚 / 全能性 / 栄養膜 / トランスポゾン / トランスポザーゼ / トランスジェニック / トランスポゾンベクター / 子宮 / 着床 / 栄養膜幹細胞 / 栄養膜肝細胞 / ノックアウトマウス / イメージング / 腫瘍血管新生 / エキソサイトーシス / リンパ管新生 / 遺伝子改変 / マウス / アリル特異的遺伝子改変 / 常染色体多発性嚢胞腎 / 多発性嚢胞腎 / ゲノム編集 / 胚性幹細胞 / 遺伝子発現 / 多能性幹細胞 / 細胞生物学 / 腫瘍 / 蛍光タンパク質 / ライブイメージング / がん / 網膜 / モデルマウス / VEGF / Flk1 / 臓器発生 / 自己複製 / ES細胞 / 発生学 / 細胞周期 / 幹細胞 / 遺伝子 / 発現制御 … More Except Principal Investigator ゲノム編集 / 血管新生 / カニクイザル / 神経膠腫 / 遺伝子 / グリオーマ / 血管新生抑制 / 発生 / iPS細胞 / blastoid / キメラ / 霊長類 / チンパンジー / 多能性幹細胞 / タンパク質分解 / 霊長類モデル / 老化 / 近赤外 / Max / c-Myc / アポトーシス / 細胞増殖 / がん細胞 / ES細胞 / 遺伝子発現 / 管腔形成 / 神経血管ワイアリング / siRNA / 遺伝子改変マウス / 蛍光タンパク質 / in vivoイメージング / 動物モデル / 蛍光イメージング / 動物 / バイオテクノロジー / 応用動物 / SDF1 / CXCR7 / SDF-1 / ケモカイン / 統合胚 / ノックインマウス / 変異遺伝子スクリーニング / Fused in sarcoma (FUS) / 低分子スクリーニング / RNA / DHX30 / FUS / 筋萎縮性側索硬化症 / caspase 3 / ALS / TDP-43 / レポーターアッセイ / CRISPR-Cas9 / ヒトiPS細胞 / DNAリピート / ゲノム解析 / 脳動脈瘤 / kidney / endothelium / cerebral aneurysm / PKD / 臓器再生 / 再生医療 / 繁殖 / 臓器移植 / ナイーブ型多能性幹細胞 / 多能性 / 早期老化症候群 / MYC / Myc / MAX / c-MYC / 転写因子 / 転写 / プロテアソーム / アンチエイジング / タンパク質恒常性 / western解析 / RT-PCR解析 / 免疫組織化学 / Slit2 / in vivo imaging / 脳腫瘍増殖制御 / 血管内皮細胞 / 神経血管ワイヤリング / slit2 / 低酸素誘導因子 / chetomin / lenalidomide / 血管新生抑制療法 / マウス / イメージング / モデルマウス / 非侵襲 / 蛍光 / 遺伝子編集 / レンチウイルスベクター / 病理学 / トランスレーショナルリサーチ / 癌 / 応用科学 / 光学的窓 / 工学的窓 / 近赤外蛍光タンパク質 / リサーチバイオリソース / 癌細胞 / Nucleostemin / 膠芽種 / 悪性脳腫瘍 / 微小血管内皮細胞 / IDH1 / 腫瘍幹細胞 / 間葉系幹細胞 / ペプチド療法 / 脳腫瘍 / 予後因子 / 血管密度 / 内皮細胞 / VEGF / RANTES / 周皮細胞 / 微小環境 / 内皮細胞ワクチン / metronomic treatment / low molecular weight heparin / bevacizumab / 光線力学療法 / Notchシグナル / マイクロアレイ / 腫瘍微小環境 / 抵抗性 / 腫瘍内皮細胞 / 膠芽腫 / 発光タンパク質 / 薬物動態 / 神経活動 / Tgマウス / 神経科学 / 血管内皮増殖因子 / 再生医学 / 脳神経疾患 / CXCR4 / 低酸素 / 腫瘍血管内皮細胞 / 血管内皮前駆細胞 / 脳腫瘍学 Less

非ヒト霊長類のための高精度ゲノム編集技術基盤の開発と難病モデルへの適用Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Shiga University of Medical Science
Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALS
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
非ヒト霊長類の着床、胎盤形成機構の解明とヒトへの展開Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Shiga University of Medical Science
in vivo development of non-human primate blastoids
- Principal Investigator
  
  正木英樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokyo Medical and Dental University
PKD遺伝子異常に伴う脳動脈瘤発生の病態解明
- Principal Investigator
  
  野崎和彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
Reconstitution of implantation process with primate endometrial organoidPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Shiga University of Medical Science
Inner cell mass dynamism and totipotency in primatePrincipal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
- Principal Investigator
  
  漆谷真
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Developing a versatile technique to create transgenic rodents and medium sized animalsPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Shiga University of Medical Science
Evaluating the role of cis-regulatory tandem DNA repeats in human disease and evolution
- Principal Investigator
  
  Woltjen Knut
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Kyoto University
Origin of placental tissues in cynomolgus monkeyPrincipal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Development of in vitro chimera assay system utilizing cynomolgus monkey embryos
- Principal Investigator
  
  Hideki Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Tokyo Medical and Dental University
  The University of Tokyo
Development of diagnosis and therapy for aging using a nonhuman primate model of premature aging
- Principal Investigator
  
  Itoh Yasushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Shiga University of Medical Science
Development of genome editing technique in monkey and it's application to ADPKD monkey modelPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Shiga University of Medical Science
Elucidation of the molecular mechanism to maintain hierarchical structure of vascular system and and tumour angiogenesisPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Shiga University of Medical Science
Molecular analysis of the proteasome gene expression and its application to anti-aging.
- Principal Investigator
  
  KOBAYASHI AKIRA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Doshisha University
Molecular bases for masking c-MYC dependent apoptosis common in embryonic stem cells and cancer cells
- Principal Investigator
  
  OKUDA AKIHIKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Saitama Medical University
New technique to sort cells expressing a gene of interestPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
Development and application of advanced non-invasive imaging system for mice
- Principal Investigator
  
  Mira Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Anti-angiogenic therapy for brain tumors targeting neuro-vascular wiring molecules
- Principal Investigator
  
  TAKANO SHINGO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  University of Tsukuba
Development of new in vivo imaging technologies by using biological optical window
- Principal Investigator
  
  Takahashi Satoru
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Generations of mice for imaging of cardiovascular systemPrincipal Investigator
- Principal Investigator
  
  Ema Masatsugu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
Development of a premature aging syndrome non-human primate model
- Principal Investigator
  
  Itoh Yasushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
血管と諸器官のワイアリング機構Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Eradication of cancer cells by controlling Max and/or nucleostemin expression
- Principal Investigator
  
  Okuda Akihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Saitama Medical University
Anti-angiogenic therapy for glioma beyond VEGF inhibition based on tumor microenvironment
- Principal Investigator
  
  TAKANO Shingo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
血管内皮細胞と諸器官のワイアリング機構の解明Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Analysis of physiological functions of novel endothelial-enriched genesPrincipal Investigator
- Principal Investigator
  
  EMA Masatsugu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
  University of Tsukuba
Development of basic technologies for new in vivo imaging to promote life science research
- Principal Investigator
  
  TAKAHASHI Satoru
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Progress of anti-angiogenic therapy for brain tumors : new modality and resolution of the resistance
- Principal Investigator
  
  TAKANO Shingo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Klf5による幹細胞維持機構Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Flk1陽性多能性中胚葉細胞と周囲細胞群の運命決定機構Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Elucidation of functional roles of new genes in angiogenesisPrincipal Investigator
- Principal Investigator
  
  EMA Masatsugu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Tsukuba
血管新生に於ける新規遺伝子群の機能解明Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  University of Tsukuba
Antiangiogenic therapy using endothelial progenitor cells for malignant tumors
- Principal Investigator
  
  TAKANO Shingo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Wnt誘導型転写因子BTEB2の幹細胞維持における生理機能の解明Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
血島を構成する未分化中胚葉細胞からの血管内皮・血球細胞の発生機構Principal Investigator
- Principal Investigator
  
  依馬正次
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba

[Book] マカクにおける遺伝子改変技術と疾患モデルの作製2023
- Author(s)
  松本翔馬, 依馬正次
- Total Pages
  10
- Publisher
  生体の科学
- Data Source
  KAKENHI-PUBLICLY-22H04669
[Book] マカクにおける遺伝子改変技術と疾患モデルの作製2023
- Author(s)
  松本翔馬、依馬正次
- Total Pages
  2
- Publisher
  生体の科学
- Data Source
  KAKENHI-PROJECT-21H02388
[Book] 発生期における血管形成制御因子の網羅的探索2013
- Author(s)
  依馬正次, 吉原雅大
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Similarities and differences in placental development between humans and cynomolgus monkeys2023
- Author(s)
  Matsumoto Shoma、Okamura Eiichi、Muto Masanaga、Ema Masatsugu
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 22 Issue: 1 Pages: 1-10
- DOI
  10.1002/rmb2.12522
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19247, KAKENHI-PUBLICLY-22H04669
[Journal Article] Signal regulatory protein alpha is a conserved marker for mouse and rat spermatogonial stem cells2023
- Author(s)
  Miyazaki Takehiro、Kanatsu-Shinohara Mito、Ema Masatsugu、Shinohara Takashi
- Journal Title
  
  Biology of Reproduction
  
  Volume: 108 Issue: 4 Pages: 682-693
- DOI
  10.1093/biolre/ioad006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15690, KAKENHI-PROJECT-22K19429, KAKENHI-PROJECT-22K19247, KAKENHI-PUBLICLY-22H04669, KAKENHI-PROJECT-23H00399
[Journal Article] Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation2023
- Author(s)
  Okamura E, Mizuno S, Matsumoto S, Murata K, Tanimoto Y, Huong DT, Suzuki H., Kang W, Ema T, Morimoto K, Kato K, Matsumoto T, Masuyama N, Kijima Y, Morimura T, Sugiyama F, Takahashi S, Mizutani E, Woltjen K, Yachie N, Ema M
- Journal Title
  
  bioRxiv
  
  Volume: 10 Pages: 1-10
- DOI
  10.1101/2023.12.10.570953
- Open Access
- Data Source
  KAKENHI-PROJECT-21H02388
[Journal Article] Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease2019
- Author(s)
  Tsukiyama T, Kobayashi K, Nakaya M, Iwatani C, Seita Y, Tsuchiya H, Matsushita J, Kitajima K, Kawamoto I, Nakagawa T, Fukuda K, Iwakiri T, Izumi H, Itagaki I, Kume S, Maegawa H, Nishinakamura R, Nishio, Nakamura S, Kawauchi A, Ema M
- Journal Title
  
  Nature Communications
  
  Volume: 10 (1) Issue: 1 Pages: 5517-5517
- DOI
  10.1038/s41467-019-13398-6
- NAID
  120006773159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22363, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K09679, KAKENHI-PROJECT-16K20131
[Journal Article] Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells2019
- Author(s)
  Watanabe C., Matsushita J., Azami T., Tsukiyama-Fujii S., Tsukiyama T., Mizuno S., Takahashi S., and Ema M.
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 1 Pages: e0210060-e0210060
- DOI
  10.1371/journal.pone.0210060
- NAID
  120007128325
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-18H02363
[Journal Article] Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system2018
- Author(s)
  Herz Katia、Becker Alexandra、Shi Chenyue、Ema Masatsugo、Takahashi Satoru、Potente Michael、Hesse Michael、Fleischmann Bernd K.、Wenzel Daniela
- Journal Title
  
  Angiogenesis
  
  Volume: 21 Issue: 2 Pages: 349-361
- DOI
  10.1007/s10456-018-9601-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221004
[Journal Article] Fluorescence and Bioluminescence imaging of angiogenesiss in Flk1-nano-lantern Transgenic mice2017
- Author(s)
  Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M
- Journal Title
  
  Sci. Rep
  
  Volume: 7 Issue: 1 Pages: 46597-46597
- DOI
  10.1038/srep46593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04281
[Journal Article] Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.2017
- Author(s)
  Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 46597-46597
- DOI
  10.1038/srep46597
- NAID
  120007129140
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290030, KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-16H02470, KAKENHI-PROJECT-16K08479, KAKENHI-PUBLICLY-16H01630, KAKENHI-PROJECT-16H06147
[Journal Article] Visualization of the Epiblast 1 and Visceral Endodermal Cells using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells2016
- Author(s)
  Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M.
- Journal Title
  
  PLoS One.
  
  Volume: 16(1) Issue: 7 Pages: 310-310
- DOI
  10.1371/journal.pone.0159246
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-15K21080
[Journal Article] Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells.2016
- Author(s)
  Khoa le TP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M.
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 3 Pages: e0150715-e0150715
- DOI
  10.1371/journal.pone.0150715
- NAID
  120007129540
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290030, KAKENHI-PROJECT-15K14361
[Journal Article] Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body2016
- Author(s)
  Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 24868-24868
- DOI
  10.1038/srep24868
- NAID
  130007023590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26640053, KAKENHI-PROJECT-15K21080, KAKENHI-PROJECT-16H04671, KAKENHI-PROJECT-26430070, KAKENHI-PROJECT-26870282, KAKENHI-PROJECT-16K14578
[Journal Article] Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.2015
- Author(s)
  Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y.
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Issue: 1 Pages: 7925-7925
- DOI
  10.1038/ncomms8925
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430002, KAKENHI-PROJECT-26440044, KAKENHI-PROJECT-15K19001, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-15H02503, KAKENHI-PROJECT-26670107, KAKENHI-PROJECT-24300330, KAKENHI-PROJECT-25293050, KAKENHI-PROJECT-26290030, KAKENHI-PROJECT-26305006
[Journal Article] Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression2015
- Author(s)
  Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki, Okuda A.
- Journal Title
  
  STEM CELLS
  
  Volume: 33 Issue: 4 Pages: 1089-1101
- DOI
  10.1002/stem.1918
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25670147, KAKENHI-PROJECT-25860244, KAKENHI-PUBLICLY-26112512, KAKENHI-PROJECT-26670162, KAKENHI-PROJECT-15K14361, KAKENHI-ORGANIZER-25112001
[Journal Article] Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus2015
- Author(s)
  Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W, Momose A
- Journal Title
  
  Development
  
  Volume: 142 Pages: 3912-3920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290030
[Journal Article] Functional crosstalk between Myc and PI3K signaling for supporting unlimited self-renewal of embryonic stem cells2015
- Author(s)
  Hishida T, Nakachi Y, Mizuno Y, Katano M, Okazaki Y, Ema M, Takahashi S, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Hishida-Nozaki Y, Vazquez-Ferrer E, Sancho-Martinez I, Izpisua Belmonte JC, Okuda A.
- Journal Title
  
  STEM CELLS
  
  Volume: 33 Issue: 3 Pages: 713-725
- DOI
  10.1002/stem.1893
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25670147, KAKENHI-PROJECT-25860244, KAKENHI-PUBLICLY-26112512, KAKENHI-PROJECT-26670162, KAKENHI-PROJECT-15K14361, KAKENHI-INTERNATIONAL-15K21737, KAKENHI-ORGANIZER-25112001
[Journal Article] CXCL12 secreted from glioma stem cells regulates their proliferation2014
- Author(s)
  Uemae Y, Ishikawa E, Osuka S, Matsuda M, Sakamoto N, Takano S, Nakai K, Yamamoto T, Matsumura A
- Journal Title
  
  J Neurooncol
  
  Volume: 117 Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390339
[Journal Article] Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses.2014
- Author(s)
  Muramoto Y, Shoemaker JE, Le MQ, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y.
- Journal Title
  
  Journal of Virlogy
  
  Volume: 88(16) Issue: 16 Pages: 8981-8997
- DOI
  10.1128/jvi.00907-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J01509, KAKENHI-PROJECT-23000012, KAKENHI-PROJECT-23590145, KAKENHI-PROJECT-25670216, KAKENHI-PROJECT-26293095, KAKENHI-PROJECT-26640053, KAKENHI-PROJECT-26850180
[Journal Article] Generation and Characterization of Ins1-cre-driver C57BL/6N for Exclusive Pancreatic Beta Cell-specific Cre-loxP Recombination2014
- Author(s)
  Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K
- Journal Title
  
  Exp Animal
  
  Volume: 63 Pages: 183-191
- NAID
  130003391621
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/24770644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009
[Journal Article] Neurons limit angiogenesis by titrating VEGF in retina.2014
- Author(s)
  Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M, Kubota Y.
- Journal Title
  
  Cell
  
  Volume: 159 Pages: 584-596
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25122702
[Journal Article] Clgalt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes2013
- Author(s)
  Kudo T, et al. (13人中8番目)
- Journal Title
  
  Blood
  
  Volume: 122 Issue: 9 Pages: 1649-1657
- DOI
  10.1182/blood-2012-12-471102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00028, KAKENHI-PROJECT-23500488, KAKENHI-PROJECT-23791069, KAKENHI-PLANNED-24108006, KAKENHI-PROJECT-24241073, KAKENHI-PROJECT-24300152, KAKENHI-PROJECT-24590498, KAKENHI-PUBLICLY-25122702
[Journal Article] Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors2013
- Author(s)
  Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 183 Issue: 2 Pages: 592-603
- DOI
  10.1016/j.ajpath.2013.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25670147
[Journal Article] In vivo monitoring of pancreatic β-cell mass and intrahepatic insulin gene activity in Ins1-luc BAC transgenic mice by bioluminescence imaging.2013
- Author(s)
  Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Ema M, Kudo T, Takahashi S.
- Journal Title
  
  Plos One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009
[Journal Article] Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method2013
- Author(s)
  Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: i435(4) Issue: 4 Pages: 586-91
- DOI
  10.1016/j.bbrc.2013.05.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23500490, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
[Journal Article] In vivo monitoring of pancreatic β -cell mass and intrahepatic insulin gene activity in Ins1-luc BAC transgenic mice by bioluminescence imaging2013
- Author(s)
  Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Ema M, Kudo T, Takahashi S
- Journal Title
  
  Plos One
  
  Volume: 8 Issue: 4 Pages: e60411-e60411
- DOI
  10.1371/journal.pone.0060411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-23590325, KAKENHI-PROJECT-24650228, KAKENHI-PROJECT-221S0001
[Journal Article] Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination2013
- Author(s)
  Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K-I
- Journal Title
  
  Exp Animal
  
  Volume: 62 Pages: 295-304
- NAID
  130003382716
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/?term=Hasegawa+Y%2C+Daitoku+Y%2C+Sekiguchi+K
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009
[Journal Article] Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture2013
- Author(s)
  Lebrun C., Avci HX., Wehrlé R., Doulazmi M., Jaudon F., Morel MP., Rivals I., Ema M., Schmidt S., Sotelo C., Vodjdani G., Dusart I
- Journal Title
  
  Mol Cell Neurosci
  
  Volume: 54 Pages: 9-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Bioluminescence imaging of β cells and intrahepatic insulin gene activity under normal and pathological conditions2013
- Author(s)
  Katsumata T, Oishi H, Sekiguchi Y, Nagasaki H, Daassi D, Tai PH, Ema M, Kudo T, Takahashi S
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes2013
- Author(s)
  Kudo T, Sato T, Hagiwara K, Kozuma Y, Yamaguchi T, Ikehara Y, Hamada M, Matsumoto K, Ema M, Murata S, Ohkohchi N, Narimatsu H, Takahashi S
- Journal Title
  
  Blood
  
  Volume: 122 Pages: 1649-1657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.2013
- Author(s)
  Hasegawa Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K-i.
- Journal Title
  
  Experimental Animals
  
  Volume: 62 Pages: 295-304
- NAID
  130003382716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009
[Journal Article] In vivo function and evolution of the eutherian-specific pluripotency marker UTF1.2013
- Author(s)
  Nishimoto M, Katano M, Yamagishi T, Hishida T, Kamon M, Nabeshima Y, Nabeshima Y, Katsura Y, Satta Y, Deakin J E, Graves J A M, Kuroki Y, Ono R, Ishino F, Okazaki Y, Kato H and Okuda A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: 68119-68119
- DOI
  10.1371/journal.pone.0068119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221010, KAKENHI-PUBLICLY-24113507, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25670147, KAKENHI-PROJECT-25860244
[Journal Article] Endothelial cell-enriched genes in the mouse embryo2012
- Author(s)
  Takase H, Takano S, Ema M et al
- Journal Title
  
  Blood 2012
- Data Source
  KAKENHI-PROJECT-21390403
[Journal Article] Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells2012
- Author(s)
  Avci HX., Lebrun C., Wehrlé R., Doulazmi M., Chatonnet F., Morel MP., Ema M., Vodjdani G., Sotelo C., Flamant F., Dusart I
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 14206-14211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice2012
- Author(s)
  Matsumoto K., Azami T., Otsu A., Takase H., Ishitobi H., Tanaka J., Miwa Y., Takahashi S., Ema M
- Journal Title
  
  Genesis
  
  Volume: 50 Pages: 561-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo2012
- Author(s)
  Takase H, Matsumoto H, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M
- Journal Title
  
  Blood
  
  Volume: 120 Issue: 4 Pages: 914-923
- DOI
  10.1182/blood-2011-12-398156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-22590282, KAKENHI-PROJECT-23500488, KAKENHI-PROJECT-24791634, KAKENHI-PUBLICLY-23122503
[Journal Article] Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice2012
- Author(s)
  Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M, Kojima T, Uchida K, Kato M, Miyata T, Takahashi S
- Journal Title
  
  J. Biochem
  
  Volume: 152 Pages: 549-555
- NAID
  10031166173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Glioma immunotherapy with combined autologous tumor celland endothelial vaccination in vivo2012
- Author(s)
  Sakamoto N, Uemae Y, Ishikawa E, Takano S, Nakai K, Yamamoto T, Zaboronok A, Matsumura A
- Journal Title
  
  Neurol Med Chir (Tokyo)
  
  Volume: 52 Pages: 194-201
- Data Source
  KAKENHI-PROJECT-21390403
[Journal Article] Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice2012
- Author(s)
  Sano K., Katsuta O., Shirae S., Kubota Y., Ema M., Suda T., Nakamura M., Hirashima M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Pages: 422-427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Journal Article] Study of normal and pathological blood vessel morphogenesis in Flt1-tdsRed BAC Tg mice2012
- Author(s)
  Matsumoto K, Azami T, Otsu A, Takase H, Ishitobi H, Tanaka J, Miwa Y, Takahashi S, Ema M
- Journal Title
  
  Genesis
  
  Volume: 50 Issue: 7 Pages: 561-571
- DOI
  10.1002/dvg.22031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-23500488, KAKENHI-PUBLICLY-23122503
[Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011
- Author(s)
  Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
- Journal Title
  
  J Exp Med
  
  Volume: 208 Issue: 5 Pages: 949-960
- DOI
  10.1084/jem.20102187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PUBLICLY-22021019, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-22390096, KAKENHI-PUBLICLY-23111536, KAKENHI-PUBLICLY-23118527, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-23790533
[Journal Article] Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse2011
- Author(s)
  Ishitobi H, Wakamatsu A, Lui F, Azami T, Hamada M, Matsumoto K, Kataoka H, kobayashi M, Choi K, Nishikawa S-I, Takahashi S, Ema M
- Journal Title
  
  Development
  
  Volume: 138 Issue: 24 Pages: 5357-5368
- DOI
  10.1242/dev.065565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-21659043
[Journal Article] Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse2011
- Author(s)
  Ishitobi, H, Wakamatsu A, Liu F, Azami T, Hamada M, Matsumoto K, Kataoka H, Kobayashi M, Choi K, Nishikawa S, -I, Takahashi S, Ema, M
- Journal Title
  
  Development
  
  Volume: 138 Pages: 5357-5368
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23122503
[Journal Article] Indefinite self-renewal of ES cells through Myc/Max transcriptional complexes-independent mechanisms2011
- Author(s)
  Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A
- Journal Title
  
  Cell Stem Cell
  
  Volume: 9 Issue: 8 Pages: 37-49
- DOI
  10.1002/stem.1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009, KAKENHI-PROJECT-22501017, KAKENHI-PROJECT-22590275
[Journal Article] Flk1-GFP BAC Tg mice : an animal model for the study of blood vessel development2010
- Author(s)
  Ishitobi H, Matsumoto K, Azami T, Itoh F, Itoh S, Takahashi S, Ema M
- Journal Title
  
  Exp Anim (Experimental Animals(日本実験動物学会機関誌)2010年最優秀論文賞受賞 )
  
  Volume: 59 Pages: 615-622
- NAID
  130000419256
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21030789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220009
[Journal Article] Kruppel-like factor 5 Is Essential For Blastocyst Development and the Normal Self-Renewal of Mouse ES cell2008
- Author(s)
  Ema, M., et.al.
- Journal Title
  
  Cell Stem Cell 3
  
  Pages: 555-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20052008
[Journal Article] Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo.2007
- Author(s)
  Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M
- Journal Title
  
  EMBO.J 26
  
  Pages: 184-194
- Data Source
  KAKENHI-PROJECT-17045004
[Journal Article] Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin and CD34 in the mouse embryo.2006
- Author(s)
  Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S
- Journal Title
  
  Blood 108
  
  Pages: 4018-4024
- Data Source
  KAKENHI-PROJECT-17045004
[Journal Article] Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival.2006
- Author(s)
  Wada T, Haigh JJ, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D
- Journal Title
  
  J Neurosci. 26
  
  Pages: 6803-6812
- Data Source
  KAKENHI-PROJECT-17045004
[Journal Article] Deletion of selection cassette but not cis-acting elements in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors.2006
- Author(s)
  Ema M, Takahashi S, Rossant J.
- Journal Title
  
  Blood. 107
  
  Pages: 111-117
- Data Source
  KAKENHI-PROJECT-17045004
[Journal Article] Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival.2006
- Author(s)
  Eremina V Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, Ema M, Rossant J, Jothy S, Miner JH, Quaggin SE.
- Journal Title
  
  J Am Soc Nephrol. 17
  
  Pages: 724-735
- Data Source
  KAKENHI-PROJECT-17045004
[Journal Article] Genome-wide identification of endothelial cell-enriched genes in the mouse embryo
- Author(s)
  Takase H., Matsumoto K., Yamadera R., Kubota Y., Otsu A., Suzuki R., Ishitobi H., Mochizuki H., Kojima T., Takano S., Uchida K., Takahashi S., Ema M
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 914-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 試験管内人工着床系開発に向けたカニクイザル着床期子宮内膜オルガノイドの構築2023
- Author(s)
  松本翔馬, 小原実穂, 山海直, 依馬正次.
- Organizer
  第64回日本卵子学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19247
[Presentation] カニクイザル胎盤発生機序の解明2023
- Author(s)
  松本翔馬, 依馬正次
- Organizer
  第116回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-22K19247
[Presentation] Modeling Autosomal Dominant Polycystic Kidney Disease with Genome-Edited Cynomolgus Monkeys2023
- Author(s)
  Masatsugu Ema
- Organizer
  ゲノム編集学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02388
[Presentation] PKD1ノックアウトカニクイザルの作製・解析と今後の展開2022
- Author(s)
  依馬　正次
- Organizer
  日本毒性学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02388
[Presentation] 遺伝子改変カニクイザルを用いたヒト疾患モデリング2021
- Author(s)
  依馬　正次
- Organizer
  再生医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02388
[Presentation] Genetically Modified Cynomolgus Monkeys for Human Autosomal Dominant Polycystic Kidney Disease Modeling2020
- Author(s)
  依馬正次
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22363
[Presentation] Genetically Modified Cynomolgus Monkeys for Human Autosomal Dominant Polycystic Kidney Disease Modeling2019
- Author(s)
  依馬　正次
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22363
[Presentation] Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice2016
- Author(s)
  M Ema, S Inagaki, T Nishie, T Sakasai, J Tanaka, Y Miwa, K Matsumoto, K Takara, H Naito, H Kidoya, N Takakura, T Nagai, S Takahashi, J Matsushita
- Organizer
  血管生物医学会
- Place of Presentation
  長崎
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-26290030
[Presentation] Origin of cardiovascular cells and heart development controlled by VEGF-Flk1 signaling2014
- Author(s)
  Masatsugu Ema, Ayaka Otsu, Takuya Azami, Masanori Hirashima , Kazuko Koshiba-Takeuchi , Jun Takeuchi , Masabumi Shibuya, Janet Rossant, Satoru Takahashi, Tomomi Nishie
- Organizer
  第91回生理学会大会, シンポジウム講演
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] Origin of cardiovascular cells and heart development controlled by VEGF-Flk1 signaling2014
- Author(s)
  依馬　正次
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PUBLICLY-25122702
[Presentation] VEGF-Flk1による心臓発生のメカニズム2014
- Author(s)
  西江友美, 大津彩香, 平島正則, 小柴和子, 竹内純, 渋谷正史, Janet Rossant, 高橋智, 依馬正次
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-25122702
[Presentation] Origin of cardiovascular cells and heart development controlled by VEGF-Flk1 signaling2014
- Author(s)
  依馬　正次
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Invited
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 心血管系細胞の起源と血管による心臓発生制御2013
- Author(s)
  依馬正次
- Organizer
  第36回分子生物学会年会(ワークショップ)オーガナイザー
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 血管内皮細胞関連遺伝子の網羅的探索による血管形成機序の解明2013
- Author(s)
  依馬正次
- Organizer
  第21回日本血管生物医学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 血管内皮細胞を可視化するためのFlk1-GFPおよびFlt1-tdsRed BACトランスジェニックマウスの作製2013
- Author(s)
  松本健、浅見拓哉、高橋智、依馬正次
- Organizer
  実験動物学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21220009
[Presentation] 心血管系細胞の起源と血管による心臓発生制御2013
- Author(s)
  依馬　正次
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 生物発光イメージングを用いた膵β細胞および肝内インスリン遺伝子発現の可視化2013
- Author(s)
  大石久史、勝又斗紀夫、関口有佳里、長崎はるか、ダーシドーハ、依馬正次、工藤崇、高橋智
- Organizer
  実験動物学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21220009
[Presentation] Cre/loxP遺伝子組換え前後を異なる蛍光タンパク質でモニターするRosa26ノックインマウスC57BL/6Nマウス2013
- Author(s)
  大徳陽子、長谷川賀一、谷本陽子、村上亞弓、門田雅世、橋本知美、目加田和之、中田初美、吉木淳、三輪佳宏、依馬正次、水野聖哉、杉山文博、八神健一、高橋智
- Organizer
  実験動物学会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-21220009
[Presentation] 心血管系細胞の起源と血管による心臓発生制御2013
- Author(s)
  依馬　正次
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PUBLICLY-25122702
[Presentation] 血管内皮細胞の発生・分化の分子機構2012
- Author(s)
  依馬正次
- Organizer
  日本解剖学会総会(招待講演)
- Place of Presentation
  甲府
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 心臓発生におけるVEGF受容体の役割2012
- Author(s)
  大津彩香、若松麻美、石飛博之、平島正則、小柴和子、竹内純、渋谷正史、Janet Rossant、高橋智、依馬正次
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PUBLICLY-23122503
[Presentation] Genome-wide discovery of novel genes specific for endothelial cells2012
- Author(s)
  松本健、高瀬春華、依馬正次
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京
- Year and Date
  2012-12-10
- Data Source
  KAKENHI-PUBLICLY-23122503
[Presentation] 生物発光イメージングによるIns1-luc-BACトランスジェニックマウスを用いた膵β細胞量と肝臓でのインスリン遺伝子発現活性化能の検出2012
- Author(s)
  勝又斗紀夫、大石久史、関口有佳里、長崎はるか、ダーシドーハ、依馬正次、工藤崇、高橋智
- Organizer
  分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21220009
[Presentation] Genome-wide identification of angiogenesis- related genes in the mouse embryo2012
- Author(s)
  Masatsugu Ema
- Organizer
  第21回日本血管生物医学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 血管内皮細胞の発生・分化の分子機構2012
- Author(s)
  依馬正次、松本健、高瀬春華、大津彩香、高橋智
- Organizer
  日本解剖学会総会
- Place of Presentation
  甲府
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PUBLICLY-23122503
[Presentation] Genome-wide discovery of novel gene2011
- Author(s)
  依馬正次
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] Genome-wide discovery of novel gene2011
- Author(s)
  依馬正次
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] Genome-wide discovery of novel genes specific for endothelial cells2011
- Author(s)
  高瀬春華、松本健、山寺里枝、大津彩香、石飛博之、小島孝宏、内田和彦、高橋智、依馬正次
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PUBLICLY-23122503
[Presentation] 新規血管内皮細胞特異的遺伝子群の網羅的探索2011
- Author(s)
  松本健, 高瀬春華, 山寺里枝, 大津彩香, 石飛博之, 小島崇宏, 内田和彦, 高橋智, 依馬正次
- Organizer
  第34回分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23500488
[Presentation] 血管内皮細胞を可視化するためのFlk1-GFPおよびFlt1-tdsRed BACトランスジェニックマウスの作製2011
- Author(s)
  松本健、石飛博之、浅見拓哉、伊東史子、伊東進、田中順子、三輪佳宏、高橋智、依馬正次
- Organizer
  実験動物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21220009
[Presentation] 血管内皮細胞を可視化するためのFlk1-GFPおよびFlt1-DsRed BACトランスジェニックマウスの作製2010
- Author(s)
  松本健、石飛博之、浅見拓哉、伊東史子、伊東進、田中順子、三輪佳宏、高橋智、依馬正次
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20590273
[Presentation] 血管内皮細胞を可視化するためのFlk1-GFP およびFlt1-DsRed BAC トランスジェニックマウスの作製2010
- Author(s)
  松本健、石飛博之、浅見拓哉、伊東史子、伊東進、田中順子、三輪佳宏、高橋智、依馬正次
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590273
[Presentation] The role of chemokine SDF-1/CXCR4/CXCR7 for glioblastoma angiogenesis and glioblastoma derived endothelial cells2009
- Author(s)
  Takano S, Ema M, Ohneda O, Ishikawa E etal
- Organizer
  The 3^<rd> Quadrennial Meeting of the WFNO
- Place of Presentation
  横浜
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390403
[Presentation] 新規血管内皮細胞特異的遺伝子群の網羅的探索2009
- Author(s)
  松本健、高瀬春香、鈴木留美子、山寺里枝、大津彩香、石飛博之、小島崇宏、内田和彦、高橋智、依馬正次
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590273
[Presentation] SDF-1 and CXCR7 are key molecules for glioma angiogenesis and invasiveness2009
- Author(s)
  高野晋吾, Ema M, 石川栄一, 大根田修, et al.
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390403
[Presentation] SDF-1 and CXCR7 are key molecules for glioma angiogenesis and invasiveness2009
- Author(s)
  Takano S, Ema M, Ishikawa E, Ohneda O etal
- Organizer
  第68 回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21390403
[Presentation] 新規血管内皮特異的遺伝子群の網羅的探索2008
- Author(s)
  鈴木留美子、山寺里枝、石飛博之、高橋智、依馬正次、
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20590273
[Presentation] Hematocardiovascular progenitorにおけるFlk1新規エンハンサーの機能解析2008
- Author(s)
  石飛博之、若松麻美、浜田理人、長谷川賀一、高橋智、依馬正次
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20057002
[Presentation] 新規血管内皮細胞特異的遺伝子群の網羅的探索2008
- Author(s)
  鈴木留美子、山寺里枝、石飛博之、高橋智、依馬正次
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590273

1. TAKAHASHI Satoru (50271896)

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Ema Masatsugu 依馬 正次

EMA Masatsugu 依馬 正次

依馬 正次 エマ マサツグ

Research Projects

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非ヒト霊長類のための高精度ゲノム編集技術基盤の開発と難病モデルへの適用Principal Investigator

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非ヒト霊長類の着床、胎盤形成機構の解明とヒトへの展開Principal Investigator

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Reconstitution of implantation process with primate endometrial organoidPrincipal Investigator

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Inner cell mass dynamism and totipotency in primatePrincipal Investigator

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Developing a versatile technique to create transgenic rodents and medium sized animalsPrincipal Investigator

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Origin of placental tissues in cynomolgus monkeyPrincipal Investigator

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Development of genome editing technique in monkey and it's application to ADPKD monkey modelPrincipal Investigator

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Ema Masatsugu 依馬正次

EMA Masatsugu 依馬正次

依馬正次エママサツグ