Hosono Yasuyuki 細野祥之

Researcher Number	60820363
Other IDs
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 教授 2025: 愛知県がんセンター(研究所), がん予防研究分野, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2025: 岡山大学, 医歯薬学域, 教授 2022 – 2023: 愛知県がんセンター(研究所), がん予防研究分野, 客員研究員 2018 – 2021: 愛知県がんセンター(研究所), がん標的治療TR分野, ユニット長
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields / 0901:Oncology and related fields Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56020:Orthopedics-related / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 42:Veterinary medical science, animal science, and related fields … More / Basic Section 54010:Hematology and medical oncology-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 50010:Tumor biology-related / Complex systems Less
Keywords	Principal Investigator 化合物スクリーニング / ゼブラフィッシュ / 癌・精巣RNA / リボヌクレオタンパク質 / 癌・精巣遺伝子 / シングルセルRNAシークエンス法 / CRISPRスクリーニング法 / CRISPRスクリーニング / シングルセルRNAシークエンス / PDX / 動物モデル / 転写因子 / lncRNA … More Except Principal Investigator … More ゼブラフィッシュ / 空間解析 / 薬剤耐性 / 癌 / ヒト多能性幹細胞 / 細胞老化 / 比較ゲノミクス / 小型魚類 / 微小環境 / マルチオミクス解析 / がん微小環境 / 非小細胞肺がん / 悪性リンパ腫 / マルチオミックス / AI / 融合タンパク質 / 融合遺伝子 / 動物モデル / 遺伝性腫瘍 / 固形がん / 治療化合物 / Gefitinib / グルタミン代謝 / 化合物スクリーニング / EGFR変異 / 肺癌 / ゲフィチニブ / 創薬 / ヘモペキシン / 血漿タンパクとがんの関係 / CRISPR screening / 溶血 / がん / 血漿タンパク / 血漿タンパク質 / バイオインフォマティクス / ケモインフォマティクス / ゼブラフィッシュモデル / モデルマウス / 骨伸長 / 塩酸メクリジン / FGFR3 / 軟骨無形成症 / 細胞内輸送 / メンブレントラフィック / 生体膜ダイナミクス / カベオリン / 細胞膜 / ROR1 / エンドサイトーシス / カベオラ / 癌細胞 / 肺がん / ノンコーディングRNA / システム生物学 Less

癌・生殖細胞ネットワークの解明と新たな細胞死誘導経路を標的とした新規抗がん剤開発Principal Investigator
- Principal Investigator
  
  細野祥之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
生物種を超えた多面的解析による遺伝性腫瘍の新規バリアント機能解明
- Principal Investigator
  
  奥舎有加
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
難治性肉腫における融合遺伝子の機能解明とタンパク質立体構造に基づく治療薬開発
- Principal Investigator
  
  黒住尭巨
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
37℃環境で生育する魚ガラルファを用いたヒト由来癌移植モデルの構築
- Principal Investigator
  
  島田康人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Mie University
Novel Animal Models for the Analysis of Tumor-Associated Senescent Cell Spreading
- Principal Investigator
  
  冨樫庸介
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
ヒト骨格アセンブロイドを利用した骨格形成過程の4Dバイオイメージング
- Principal Investigator
  
  宝田剛志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Okayama University
Prediction of drug efficacies with AI methodologies for the medical application of plasma proteins
- Principal Investigator
  
  澤田隆介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Okayama University
シングルセル・マルチオミクス解析がもたらすリンパ腫時空間的不均一性の解明
- Principal Investigator
  
  遠西大輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Okayama University
Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancer
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Validation and drug development for anti-cancer therapy targeting hemolysis-hemopexin related axis
- Principal Investigator
  
  逢坂大樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
固形癌における抗腫瘍薬の薬剤耐性を改善するグルタミン代謝抑制化合物の開発
- Principal Investigator
  
  増田隆明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
癌・精巣リボヌクレオタンパク質の機能解明と、新規抗がん剤創出Principal Investigator
- Principal Investigator
  
  細野祥之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Development of therapeutic drugs fro achondroplasia-Examination of FGFR3 inhibitory effects of meclizine hydrochloride
- Principal Investigator
  
  Kitoh Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Aichi Children’s Health and Medical Center
Zebrafish Patient Derived Xenograft (PDX) models for efficient in vivo gene and drug screeningPrincipal Investigator
- Principal Investigator
  
  Hosono Yasuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
  Aichi Cancer Center Research Institute
Promoter analysis of THOR, cancer-testis lncRNAPrincipal Investigator
- Principal Investigator
  
  Hosono Yasuyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Role of ROR1-mediated caveolae function in cell membrane organization and dynamics
- Principal Investigator
  
  YAMAGUCHI Tomoya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Systems analysis of roles of non-coding RNAs in lung cancer development
- Principal Investigator
  
  Takahashi Takashi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Aichi Cancer Center Research Institute
  Nagoya University

All 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish2022
- Author(s)
  Takemoto Genta、Matsushita Masaki、Okamoto Takaaki、Ito Toshinari、Matsuura Yuki、Takashima Chieko、Chen-Yoshikawa Toyofumi Fengshi、Ebi Hiromichi、Imagama Shiro、Kitoh Hiroshi、Ohno Kinji、Hosono Yasuyuki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 694018-694018
- DOI
  10.3389/fcell.2021.694018
- NAID
  120007190703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-21H03063, KAKENHI-PROJECT-19K09646, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561
[Journal Article] Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR-Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target2018
- Author(s)
  Song KA, Hosono Y, Turner C, Jacob S, Lochmann TL, Murakami Y, Patel NU, Ham J, Hu B, Powell KM, Coon CM, Windle B, Oya Y, Koblinski JE, Harada H, Leverson JD, Souers AJ, Hata AN, Boikos SA, Yatabe Y, Ebi H, Faber AC
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24 Issue: 22 Pages: 5658-5672
- DOI
  10.1158/1078-0432.ccr-18-0304
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0303, KAKENHI-PROJECT-16H05167, KAKENHI-PROJECT-19K21295, KAKENHI-PROJECT-16K07164
[Journal Article] Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.2017
- Author(s)
  Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M,Takahashi T, Mano H, Niki T.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 9 Pages: 1888-1896
- DOI
  10.1111/cas.13313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-17K07250, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-26293080, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H02468
[Presentation] ゼブラフィッシュを用いたがん研究2019
- Author(s)
  細野祥之
- Organizer
  第3回学際的がん研究夏の学校
- Data Source
  KAKENHI-PROJECT-19K21295

1. 澤田隆介 (00570433)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 山口類 (90380675)

# of Collaborated Projects: 2 results

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3. 冨田秀太 (10372111)

# of Collaborated Projects: 2 results

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4. Takahashi Takashi (50231395)

# of Collaborated Projects: 1 results

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5. YAMAGUCHI Tomoya (70452191)

# of Collaborated Projects: 1 results

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6. Kitoh Hiroshi (40291174)

# of Collaborated Projects: 1 results

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7. 梶野泰祐 (50723673)

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8. 中杤昌弘 (10559983)

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9. 柳澤聖 (20372112)

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10. 長田啓隆 (30204176)

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11. 三島健一 (40646519)

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12. 松下雅樹 (60721115)

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13. 座間味義人 (70550250)

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14. 逢坂大樹 (70839141)

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15. 王登莉 (40815693)

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16. 増田隆明 (50463493)

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17. 三森功士 (50322748)

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18. 奥舎有加 (50762027)

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19. 黒住尭巨 (50989457)

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20. 藤原智洋 (80639211)

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21. 尾崎敏文 (40294459)

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22. 林陽平 (00588056)

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23. 佐藤綾人 (10512428)

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24. 遠西大輔 (20825096)

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25. 前田嘉信 (60403474)

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26. 枝園和彦 (30708079)

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27. 豊岡伸一 (30397880)

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28. 山本寛斉 (40467733)

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29. 諏澤憲 (90839713)

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30. 島田康人 (40378427)

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31. 臧黎清 (10437105)

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32. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

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33. 宝田剛志 (30377428)

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34. 高尾知佳 (40612429)

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35. 大曽根達則 (10962243)

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36. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

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37. 衣斐寛倫

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38. 大野欽司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosono Yasuyuki 細野 祥之

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癌・生殖細胞ネットワークの解明と新たな細胞死誘導経路を標的とした新規抗がん剤開発Principal Investigator

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癌・精巣リボヌクレオタンパク質の機能解明と、新規抗がん剤創出Principal Investigator

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Zebrafish Patient Derived Xenograft (PDX) models for efficient in vivo gene and drug screeningPrincipal Investigator

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Promoter analysis of THOR, cancer-testis lncRNAPrincipal Investigator

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Hosono Yasuyuki 細野祥之