MOCHIDUKI Hideki 望月秀樹

… Alternative Names

望月秀樹モチヅキヒデキ

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Researcher Number	90230044
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Affiliation (Current)	2024: 大阪大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 教授 2014 – 2020: 大阪大学, 医学系研究科, 教授 2012 – 2017: 大阪大学, 医学(系)研究科(研究院), 教授 2015: 大阪大学, 医学部, 教授 2015: 大阪大学, 大学院医学系研究科神経内科学, 教授 … More 2011: 大阪大学, 医学部, 教授 2011: 大阪大学, 神経内科学, 教授 2009 – 2010: 北里大学, 神経内科, 教授 2007 – 2010: 順天堂大学, 医学部, 准教授 2008: 順天堂大学, 医学部, 先任准教授 2007: Juntendo University, 神経内科, Associate Professor 2006: 順天堂大学, 医学部, 講師 2005 – 2006: Juntendo University, Dept.of Neurology, Associate professor, 医学部, 助教授 1999 – 2004: 順天堂大学, 医学部, 講師 2002: 順天堂大学, 神経内科学, 講師 Less
Review Section/Research Field	Principal Investigator Neurology / Biological Sciences / Neurology / Medium-sized Section 51:Brain sciences and related fields / Basic Section 51030:Pathophysiologic neuroscience-related / Neurophysiology / General neuroscience / Basic Section 52020:Neurology-related Except Principal Investigator Neurology / Neurology / Cerebral neurosurgery … More / Medium-sized Section 53:Organ-based internal medicine and related fields / Neurophysiology / General neuroscience / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / Pediatrics / Pediatrics / Digestive surgery / Biomedical engineering/Biomaterial science and engineering / Living organism molecular science / Biological Sciences Less
Keywords	Principal Investigator パーキンソン病 / αシヌクレイン / MPTP / 遺伝子治療 / Parkinson's disease / AAV vector / アデノ随伴ウイルスベクター / 蛋白質凝集 / 構造多型 / iPS細胞 … More / α-シヌクレイン / Apaf-1-DN / 猿 / Gene therapy / ARJP / アミロイド線維 / 神経変性疾患 / 再生医療 / 神経幹細胞 / レトロウイルス / Apaf-1 / アポトーシス / 機能的アミロイド / PIP3 / 多系統萎縮症 / 疾患構造多型 / parkin / rotenone / mitochondria / Rotenone / Parkin / Mitophagy / Mitochondria / アミロイド / パーキンソン / フィブリル / シヌクレイン / バイオマーカー / 凝集 / 伝播 / alpha synuclein / 動物モデル / α-ｓｙｎ / α-syn / マーモセット / Retrovirus vector / Neuronal stem cell / Hepatocyte growth factor / Regeneration medicine / 神経栄養因子 / MTPT / HGF / 幹細胞 / レトロウイルスベクター / 肝細胞増殖因子 / Caspase 11 / alpha-synuclein / 大型動物(猿) / α-synuclein / Apaf-DN / caspase 11 / Parkin gene / 常染色体劣性遺伝若年性パーキンソン病 / パーキン遺伝子 / 神経科学 / 神経内科学 / 構造解析 / J-PARC / SPring-8 / 生物物理学 / レビー小体 / 神経炎症 / インフラマソーム / 自然免疫 / ミトコンドリア / JAK2阻害剤 / ミクログリア / インフラマゾーム / 神経細胞死 / パーキンソン病モデル猿 / アルファ・シヌクレイン / 片側パーキンソン病モデル猿 / リボザイム / リン酸化アルファ・シヌクレイン / ウイルスベクター / 移植 / 皮膚 / Mashi-1 / ガレクチン / 皮膚幹細胞 / calbindin / MnSOD / CuSOD / dominant negative / caspase-1 … More Except Principal Investigator パーキンソン病 / 遺伝子治療 / Gene therapy / PEDF / Apoptosis / アポトーシス / ミトコンドリア / 血液脳関門 / てんかん / 異染性白質ジストロフィー / リソゾーム病 / gene therapy / 神経栄養因子 / Adeno-associated virus / Striatum / Substantia nigra / MPTP / NF-kB / 脳虚血 / パッチクランプ / 神経細胞新生 / 海馬 / 神経変性疾患 / 中枢神経病変治療用外用薬 / 結節性硬化症 / 新規薬剤輸送機構 / シロリムス / シロリムス局所外用療法 / α-synucelin / 脳神経疾患 / Exosome / α-synuclein / exosome / 実験的自己免疫性脳脊髄炎 / 血管 / EAE / セマフォリン / 神経変性 / 血流 / 低酸素 / 虚血 / Sema3E / 筋萎縮性側索硬化症 / 多発性硬化症 / 脳卒中 / 神経疾患 / 低分子化合物 / TORC / エピゲノム / CREB / HDAC / SIK（塩誘導性キナーゼ） / CRTC / 創薬 / ＨＤＡＣ阻害剤 / ＨＤＡＣ（ヒストン脱アセチル化酵素） / ＳＩＫ（塩誘導性キナーゼ） / ＣＲＥＢ / シグナルトランスダクション / 立体構造予測 / SUMO化 / 翻訳後修飾 / 酸化ストレス / 活性酸素種 / 転写因子 / ユビキチン化 / 遺伝子導入 / パーキンソン病モデル / 遺伝子変異マウス / PGC-1α / 生存能 / エネルギー代謝 / ニューロン / Necdin / アミロイド線維 / 神経内科学 / レビー小体 / アミロイド / 医療診断装置 / Metachromatic leukodystrophy / Mannose-6 phosp[hate receptor / Lysosomal diseases / Blood brain barrier / Viral vector / トランスサイトーシス / マンノース6リン酸 / アリルスルファターゼ / マンノース-6-リン酸受容体 / ウイルスベクター / AAV vector / neural stem cells / stem cells / lysosomal disorders / cell therapy / 多能性骨髄幹細胞 / HIVベクター / 脂肪組織由来幹細胞 / 多能性幹細胞 / アリルサルファターゼ / 異染性ロイコジストロフィー / AAVベクター / 神経幹細胞 / 幹細胞 / 細胞治療 / Microglia / Bone marrow transplantation / Adeno-associated virus vector / Oxidative stress / Ischemic neuronal death / Cerebral infarction / GAPDH / アデノウイルスベクター / ミクログリア / 骨髄移植 / アデノ随伴ウイルスベクター / 酸化的ストレス / 虚血性神経細胞死 / 脳梗塞 / neurotrophic factor / angiogenesis / 血管新生 / Neurotrophic factor / Pigment epitheliurm-derived factori / 黒質神経細胞 / 移植 / マイクログリア / アストロサイト / レトロウィルスベクター / 黒質神経細胞死 / Neurotrophic fador / Pigment epitheliom-derived fador / Knock out mouse / Caspase-11 / Parkinson's disease / neurotoxin / ドパミン / ヅメトキツフェニルエチルアミン / パパベリン / 本年度の研究実施計画 / フリーラジカル / アデノウイルス / MnSOD / カスパーゼ11 / カスパーゼ1 / ノックアウトマウス / カスパーゼ 11 / カスパーゼ 1 / 神経毒 / 歩行リズム / 生体ゆらぎ / 臨界現象 / 拡散解析 / 非ガウス性 / 固視微動 / 姿勢動揺 / 間欠制御 / システム生理学 / 生体計測 / 生物・生体工学 / 非線形システム / 生体運動制御 / 生体シミュレーション / 生体生命情報学 / 生体医工学 / ゆらぎ / 非線形制御 / 眼球運動 / 歩行 / 姿勢制御 / 計算論的神経科学 / 運動制御 / SH-SY5Y細胞 / カルシウム非依存性フォスフォリパーゼA2β / 神経病理 / 神経筋疾患 / IRP / NBIA / 鉄調節蛋白質 / DMT1 / PLA2G6 / NBIA2 / 血管内皮細胞 / 細胞接着 / 血管内皮 / 脳小血管 / VEGF / 機能脳神経外科学 / 間欠的低酸素 / アミロイドベータ42 / アルツハイマー病 / 睡眠時無呼吸症候群 / 神経生理学 / パッチクランプ法 / 神経新生細胞 / てんかん原生 / ホールセルパッチクランプ / 神経科学 / 再生医学 / 湾曲化完全結晶 / 中間領域散乱 / 溶液散乱解析 / タンパク質溶液散乱 / 中性子広角散乱 / シヌクレイン / 中性子モノクロメータ / 中性子小角散乱 / 中性子散乱 / 動的光散乱 / 機器分析 / 14-3-3蛋白 / パーキン / 発症機序 / LRRK2 / PINK1 / parkin / alpha-synuclein / α-シヌクレイン / バーキン / 免疫機序 / 家族性パーキンソン病 / TH遺伝子 / ヒト羊膜細胞 / Parkinson病 / 細胞移植治療 / 羊膜細胞 Less

Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid FibrilsPrincipal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Osaka University
血液脳関門を介さない皮膚から脳への新規薬剤輸送機構の解明
- Principal Investigator
  
  金田眞理
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsitiesPrincipal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Development of biomarker and new therapy using the protein structurePrincipal Investigator
- Principal Investigator
  
  Mochizuki Hideki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Generation of a new mouse model using neurons derived from iPS cells of Parkinson's disease patientsPrincipal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Deciphering molecular mechanisms underlying the unconventional extracellular mitochondria releasePrincipal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Osaka University
パーキンソン病マーモセットにおけるiPS由来α-Syn蛋白伝播Principal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Study of biomarkers of Parkinson's disease by the amplification of amyloid fibrils in biological sample
- Principal Investigator
  
  Araki Katsuya
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Osaka University
Analysis of propagation molecule mechanism via exosome in Parkinson's disease related gene SNCA
- Principal Investigator
  
  Kawahara Hironori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Kanazawa University
Neural control mechanisms during gaze and posture in health and disease
- Principal Investigator
  
  Nomura Taishin
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Structure and function analysis of alpha-synuclein in Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Mochizuki Hideki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Trials to treat progressive MS
- Principal Investigator
  
  Okuno Tatsusada
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
変性疾患における神経細胞、ミクログリアの相互作用、インフラマゾームを中心にPrincipal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Dysfunction of endothelial junction by vascular risk factors in the cerebral small vessel.
- Principal Investigator
  
  YAGITA Yoshiki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
The study about the mechanism underlying brain iron accumulation in the deficiency of iPLA2 beta.
- Principal Investigator
  
  BECK Goichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Strengthening mechanism of neuronal vitality by necdin
- Principal Investigator
  
  YOSHIKAWA Kazuaki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka University
The role and mechanisms of TORC and HDAC signaling pathway and therapeutic new-class small compounds for neurological disease
- Principal Investigator
  
  sasaki tsutomu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
The effect of chronic nocturnal intermittent hypoxia in in the brain of Alzheimer's model mice
- Principal Investigator
  
  SHIOTA Satomi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Transduction of neurogenesis inducing gene to the hippocampus
- Principal Investigator
  
  SUGANO Hidenori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Juntendo University
Dentate neurogenesis and neural maturation in animal models of epilepsy
- Principal Investigator
  
  NAKAJIMA Madoka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Juntendo University
Structural study of Parkinson disease related protein by intermediate region neutron scattering method
- Principal Investigator
  
  FURUSAKA Michihiro, 内藤幸雄
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Hokkaido University
  High Energy Accelerator Research Organization
パーキンソン病における神経細胞死の機序解明とその防御
- Principal Investigator
  
  水野美邦
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
パーキンソン病におけるリン酸化アルファ・シヌクレイン制御薬剤の開発Principal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Non-invasive gene therapy for inherited neurodegenerative disorders (How to cross the BBB?)
- Principal Investigator
  
  SHIMADA Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
Enhancement of adult neurogenesis for Parkisnon's diseased primate modelsPrincipal Investigator
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
自己皮膚幹細胞を用いたパーキンソン病治療Principal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Primate Study for Gene Therapy of Porkinson's disease for clinicPrincipal Investigator
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Therapeutic strategies for inherited neurodegerative disorders using gene transfer and stem-cell transplantation technologies
- Principal Investigator
  
  SHIMADA Takashi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
Basic research of the new gene therapy for cerebral infarction
- Principal Investigator
  
  URABE takao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
パーキンソン病に対する抗アポトーシス遺伝子を用いた新たな遺伝子治療Principal Investigator
- Principal Investigator
  
  望月秀樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Gene therapy for digestive system cancer by using new antiangiogenetic factor
- Principal Investigator
  
  ATOMI Yutaka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyorin University School of Medicine
TH遺伝子を導入したヒト羊膜細胞を用いたパーキンソン病に対する細胞移植治療
- Principal Investigator
  
  北村伸
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nippon Medical School
Reseach for Gene therapy of ARJPPrincipal Investigator
- Principal Investigator
  
  MOCHIZUKI Hideki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Inhibition of neuronal cell death in Parkinson's disease by transduction of neurotrophic factor gene.
- Principal Investigator
  
  MORI Hideo, 杉田之宏
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY
Research for the pathogenesis of Parkinson's disease (microdyalisi study for neurotxin)
- Principal Investigator
  
  MIZUNO Yoshikuni, 田久保秀樹
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  JUNTENDO UNIVERSITY

[Book] Neuromyelitis Optica:Diagnosis and Treatment. Neuroimmunological Disease (Kusunoki S).2016
- Author(s)
  Nakatuji Y, Kinoshita M, Okuno T, Takata K, Koda T, Honorat JA, Sakoda S, Mochizuki H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461293
[Book] ＢＩＯ　Ｃｌｉｎｉｃａ　慢性炎症と疾患　神経系における慢性炎症2014
- Author(s)
  奥野龍禎　島上洋　望月秀樹
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PUBLICLY-24111531
[Book] 神経系の慢性炎症2014
- Author(s)
  奥野龍禎　島上洋　望月秀樹
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-26461293
[Book] Progress in Gene Therapy, Diagnosis and Clinical Management (Edition 2. Factor SA and Weiner WJ(eds)) (In : Parkinson's Disease)2007
- Author(s)
  Mochizuki H.
- Publisher
  Demos Medical Publishing(In press)
- Data Source
  KAKENHI-PROJECT-17659268
[Book] Elsevier2007
- Author(s)
  Mizuno, Y・Hattori, N・Mochiduki, H・Koller, W・Melamed, E.
- Publisher
  Genetic Aspects of Parkinson's Disease. In Handbook of Clinical Neurology, eds
- Data Source
  KAKENHI-PROJECT-17025037
[Book] Neuroprotection. In Treatment of Parkinson's disease. (Shapira AHV(ed))2006
- Author(s)
  Mochizuki H.
- Total Pages
  372
- Publisher
  Elsevier Science Publishers
- Data Source
  KAKENHI-PROJECT-17659268
[Book] Neuroprotection. In Treatment of Parkinson's disease. Shapira AHV and Olanow CW, (Ed)Woburn2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Book] Neuroprotection. In Treatment of Parkinson's disease. (Shapira AHV and Olanow CW,(Ed)) Woburn2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers(In press)
- Data Source
  KAKENHI-PROJECT-17659268
[Book] Treatment of Parkinson's disease. "Neuroprotection." (Shapira AHV and Olanow CW, (Ed))2006
- Author(s)
  Mochizuki H, Mizuno Y
- Publisher
  Elsevier Science Publishers, Woburn (In press)
- Data Source
  KAKENHI-PROJECT-16390255
[Book] Anti-apoptotic therapy for Parkinson's disease : overexpression of an apf-1-dominant-gnegative inhibitor can block MPTP toxicity. Mapping the Program of Alzheimer's and Parkinson's Disease. (edited by Mizuno et al.)2002
- Author(s)
  Mochizuki, H., Hayakawa, H., Nigita, M., Shimada, T., Masyuki, M., Mizuno, Y.
- Publisher
  Kluwer Academic Publishers
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism2023
- Author(s)
  Choong Chi-Jing、Aguirre Cesar、Kakuda Keita、Beck Goichi、Nakanishi Hiroki、Kimura Yasuyoshi、Shimma Shuichi、Nabekura Kei、Hideshima Makoto、Doi Junko、Yamaguchi Keiichi、et al.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 145 Issue: 5 Pages: 573-595
- DOI
  10.1007/s00401-023-02555-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-23K24212, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-22K07538, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K23848
[Journal Article] Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles2023
- Author(s)
  Kakuda Keita、Ikenaka Kensuke、Kuma Akiko、Doi Junko、Aguirre Cesar、Wang Nan、Ajiki Takahiro、Choong Chi-Jing、Kimura Yasuyoshi、Badawy Shaymaa Mohamed Mohamed、Shima Takayuki、Nakamura Shuhei、Baba Kousuke、Nagano Seiichi、Nagai Yoshitaka、Yoshimori Tamotsu、Mochizuki Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 1
- DOI
  10.1073/pnas.2312306120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-22K15709, KAKENHI-PROJECT-22KJ2105, KAKENHI-PROJECT-22K07516, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K24212
[Journal Article] Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane2023
- Author(s)
  Ito Naohito、Tsuji Mayumi、Adachi Naoki、Nakamura Shiro、Sarkar Avijite Kumer、Ikenaka Kensuke、Aguirre Cesar、Kimura Atsushi Michael、Kiuchi Yuji、Mochizuki Hideki、Teplow David B.、Ono Kenjiro
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 9 Issue: 1 Pages: 139-139
- DOI
  10.1038/s41531-023-00583-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18255, KAKENHI-PROJECT-20K19685, KAKENHI-PROJECT-22K07514, KAKENHI-PROJECT-22K09918, KAKENHI-PROJECT-19K07965, KAKENHI-PLANNED-23H03850, KAKENHI-PROJECT-23K24212
[Journal Article] Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor2023
- Author(s)
  Zhou Lianjie、Hajiri Touko、Nakajima Kichitaro、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Yamaguchi Keiichi、Goto Yuji、Ogi Hirotsugu
- Journal Title
  
  ACS Sensors
  
  Volume: 8 Issue: 7 Pages: 2598-2608
- DOI
  10.1021/acssensors.3c00331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K14013, KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-23K23848, KAKENHI-PROJECT-23K24212
[Journal Article] Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient ( PARK4 ) with SNCA triplication2021
- Author(s)
  Fukusumi Hayato、Togo Kazuyuki、Sumida Miho、Nakamori Masayuki、Obika Satoshi、Baba Kousuke、Shofuda Tomoko、Ito Daisuke、Okano Hideyuki、Mochizuki Hideki、Kanemura Yonehiro
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 2 Pages: 354-366
- DOI
  10.1002/2211-5463.13060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22597, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-18K07534, KAKENHI-PROJECT-23K21397
[Journal Article] Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners2021
- Author(s)
  Yamaguchi Keiichi、So Masatomo、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Kawata Yasushi、Goto Yuji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100510-100510
- DOI
  10.1016/j.jbc.2021.100510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06580, KAKENHI-PROJECT-18H02741
[Journal Article] Detection of Phosphorylated Alpha-Synuclein in the Muscularis Propria of the Gastrointestinal Tract Is a Sensitive Predictor for Parkinson’s Disease2020
- Author(s)
  Beck Goichi、Hori Yumiko、Hayashi Yoshito、Morii Eiichi、Takehara Tetsuo、Mochizuki Hideki
- Journal Title
  
  Parkinson's Disease
  
  Volume: 2020 Pages: 1-8
- DOI
  10.1155/2020/4687530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06910, KAKENHI-PROJECT-18H02741
[Journal Article] The secondary structural difference between Lewy body and glial cytoplasmic inclusion in autopsy brain with synchrotron FTIR micro-spectroscopy2020
- Author(s)
  Araki Katsuya、Yagi Naoto、Ikemoto Yuka、Hayakawa Hideki、Fujimura Harutoshi、Moriwaki Taro、Nagai Yoshitaka、Murayama Shigeo、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-100
- DOI
  10.1038/s41598-020-76565-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02741, KAKENHI-PLANNED-20H05927
[Journal Article] Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.2019
- Author(s)
  2. Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf O, Ogi H, Goto Y, Mochizuki H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 6001-6001
- DOI
  10.1038/s41598-019-42399-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-17K16122, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16K09716, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741
[Journal Article] Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein2019
- Author(s)
  Araki Katsuya、Yagi Naoto、Aoyama Koki、Choong Chi-Jing、Hayakawa Hideki、Fujimura Harutoshi、Nagai Yoshitaka、Goto Yuji、Mochizuki Hideki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 36 Pages: 17963-17969
- DOI
  10.1073/pnas.1906124116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] Interaction of nectin-2α with the auxiliary protein of the voltage-gated A-type K(+) channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula2019
- Author(s)
  Shiotani H, Miyata M, Mizutani K, Wang S, Mizoguchi A, Mochizuki H, *Mandai K, *Takai Y
- Journal Title
  
  Mol. Cell. Neurosci.
  
  Volume: 94 Pages: 32-40
- DOI
  10.1016/j.mcn.2018.11.001
- NAID
  120006850502
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06463, KAKENHI-PUBLICLY-17H05700, KAKENHI-PLANNED-26114007
[Journal Article] Structurally Distinct α‐Synuclein Fibrils Induce Robust Parkinsonian Pathology2019
- Author(s)
  Hayakawa Hideki、Nakatani Rie、Ikenaka Kensuke、Aguirre Cesar、Choong Chi‐Jing、Tsuda Hiroshi、Nagano Seiichi、Koike Masato、Ikeuchi Takeshi、Hasegawa Masato、Papa Stella M.、Nagai Yoshitaka、Mochizuki Hideki、Baba Kousuke
- Journal Title
  
  Movement Disorders
  
  Volume: 35 Issue: 2 Pages: 256-267
- DOI
  10.1002/mds.27887
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09299, KAKENHI-PROJECT-18H02718, KAKENHI-PROJECT-18H02741, KAKENHI-PROJECT-16K09690, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K19512, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease2018
- Author(s)
  Uenaka Takeshi、Satake Wataru、Cha Pei-Chieng、Hayakawa Hideki、Baba Kousuke、Jiang Shiying、Kobayashi Kazuhiro、Kanagawa Motoi、Okada Yukinori、Mochizuki Hideki、Toda Tatsushi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 27 Pages: 3974-3985
- DOI
  10.1093/hmg/ddy279
- NAID
  120006549191
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19512, KAKENHI-PUBLICLY-17H05700, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-16H05353, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-17H04056
[Journal Article] Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson's disease.2018
- Author(s)
  Takahashi H, Watanabe Y, Tanaka H, Mihara M, Mochizuki H, Liu T, Wang Y, Tomiyama N
- Journal Title
  
  The British Journal of Radiology
  
  Volume: 2 Issue: 1086 Pages: 20180037-20180037
- DOI
  10.1259/bjr.20180037
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05700, KAKENHI-PROJECT-16K01453
[Journal Article] Targeted knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism2018
- Author(s)
  Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani N, Hashimoto H
- Journal Title
  
  EMBO Reports
  
  Volume: 19(3) Issue: 3
- DOI
  10.15252/embr.201744860
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08269, KAKENHI-PROJECT-26293020, KAKENHI-PUBLICLY-17H05700, KAKENHI-PROJECT-15J06322, KAKENHI-PROJECT-17K19488, KAKENHI-PROJECT-15H04645, KAKENHI-PROJECT-17H03989
[Journal Article] New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.2018
- Author(s)
  Hirata Y, Sasaki T, Kanki H, Choong CJ, Nishiyama K, Kubo G, Hotei A, Taniguchi M, Mochizuki H, Uesato S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1400-1400
- DOI
  10.1038/s41598-018-19664-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700, KAKENHI-PROJECT-17F17413, KAKENHI-PROJECT-16K15317
[Journal Article] A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing2018
- Author(s)
  Murakami Tatsuya C.、Mano Tomoyuki、Saikawa Shu、Horiguchi Shuhei A.、Shigeta Daichi、Baba Kousuke、Sekiya Hiroshi、Shimizu Yoshihiro、Tanaka Kenji F.、Kiyonari Hiroshi、Iino Masamitsu、Mochizuki Hideki、Tainaka Kazuki、Ueda Hiroki R.
- Journal Title
  
  Nat Neurosci
  
  Volume: 21 Issue: 4 Pages: 627-637
- DOI
  10.1038/s41593-018-0109-1
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01621, KAKENHI-PUBLICLY-17H05688, KAKENHI-PUBLICLY-17H05700, KAKENHI-PLANNED-25117002, KAKENHI-PROJECT-25221004, KAKENHI-PROJECT-15H03123, KAKENHI-PROJECT-16K15124, KAKENHI-PROJECT-18K14915, KAKENHI-PUBLICLY-17H05680, KAKENHI-PUBLICLY-17H06062, KAKENHI-PROJECT-16J05041, KAKENHI-PROJECT-25221304
[Journal Article] Inappropriate trafficking of damaged mitochondria in Parkinson’s disease2017
- Author(s)
  Choong Chi-Jing、Mochizuki Hideki
- Journal Title
  
  Stem Cell Investigation
  
  Volume: 4 Pages: 17-17
- DOI
  10.21037/sci.2017.02.07
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17413
[Journal Article] Gene therapy targeting mitochondrial pathway in Parkinson’s disease2017
- Author(s)
  Choong Chi-Jing、Mochizuki Hideki
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 124 Issue: 2 Pages: 193-207
- DOI
  10.1007/s00702-016-1616-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17413
[Journal Article] Neurofeedback-induced facilitation of the supplementary motor area affects postural stability.2017
- Author(s)
  Fujimoto H, Mihara M, Hattori N, Hatakenaka M, Yagura H, Kawano T, Miyai I, Mochizuki H.
- Journal Title
  
  Neurophotonics
  
  Volume: 4 Issue: 04 Pages: 045003-045003
- DOI
  10.1117/1.nph.4.4.045003
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Journal Article] Evidence that glial cells attenuate G47R transthyretin accumulation in the central nervous system.2017
- Author(s)
  Sumi-Akamaru H, Etoh M, YamauchiA, Uehara T, Kakuda K, Obayashi K, Kato S, Naka T, Mochizuki H
- Journal Title
  
  Neuropathology
  
  Volume: 38 Issue: 1 Pages: 11-21
- DOI
  10.1111/neup.12412
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07095, KAKENHI-PUBLICLY-17H05700
[Journal Article] MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells.2017
- Author(s)
  Ito K, Eguchi Y, Imagawa Y, Akai S, Mochizuki H, Tsujimoto Y.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 3 Issue: 1 Pages: 17013-17013
- DOI
  10.1038/cddiscovery.2017.13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-15K14519
[Journal Article] A refined concept: α-synuclein dysregulation disease2017
- Author(s)
  Mochizuki Hideki、Choong Chi-Jing、Masliah Eliezer
- Journal Title
  
  Neurochemistry International
  
  Volume: S0197-0186(17)30571-5 Pages: 1-13
- DOI
  10.1016/j.neuint.2017.12.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17413
[Journal Article] Characteristics of cryptogenic stroke in cancer patients2016
- Author(s)
  Gon Y, Okazaki S, Terasaki Y, Sasaki T, Yoshimine T, Sakaguchi M, Mochizuki H.
- Journal Title
  
  Ann Clin Transl Neurol.
  
  Volume: Feb 11;3(4) Issue: 4 Pages: 280-7
- DOI
  10.1002/acn3.291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390222
[Journal Article] “Dynamical Behavior of Human α-Synuclein Studied by Quasielastic Neutron Scattering”2016
- Author(s)
  Satoru Fujiwara , Katsuya Araki, Tatsuhito Matsuo, Hisashi Yagi, Takeshi Yamada, Kaoru Shibata, Hideki Mochizuki
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 4 Pages: e0151447-e0151447
- DOI
  10.1371/journal.pone.0151447
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25790005, KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-26293210, KAKENHI-PROJECT-16K13730
[Journal Article] Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.2016
- Author(s)
  Hasegawa, K., Yasuda, T., Shiraishi, C., Fujiwara, K., Przedborski, S., Mochizuki, H., Yoshikawa, K.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 10943-10943
- DOI
  10.1038/ncomms10943
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830047, KAKENHI-PROJECT-25830053, KAKENHI-PROJECT-24300134
[Journal Article] A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.2016
- Author(s)
  Choong CJ, Sasaki T, Hayakawa H, Yasuda T, Baba K, Hirata Y, Uesato S, Mochizuki H.
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 37 Pages: 103-116
- DOI
  10.1016/j.neurobiolaging.2015.10.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-24390222
[Journal Article] A small-angle X-ray scattering study of alpha-synuclein from human red blood cells.2016
- Author(s)
  Araki K, Yagi N, Nakatani R, Sekiguchi H, So M, Yagi H, Ohta N, Nagai Y, Goto Y, Mochizuki H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 30473-30473
- DOI
  10.1038/srep30473
- NAID
  120006557626
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01558, KAKENHI-ORGANIZER-26105001, KAKENHI-PROJECT-26293210, KAKENHI-PROJECT-16K09716, KAKENHI-INTERNATIONAL-15K21719, KAKENHI-PROJECT-16H05325
[Journal Article] Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors.2016
- Author(s)
  Hatate J, Miwa K, Matsumoto M, Sasaki T, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H.
- Journal Title
  
  Parkinsonism Relat Disord.
  
  Volume: Feb 13. pii: S1353-8020(16) Pages: 30039-6
- DOI
  10.1016/j.parkreldis.2016.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-15K19227
[Journal Article] Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia2016
- Author(s)
  Watanabe A, Sasaki T, Kanki H, Yukami T, Takemori H, Sakaguchi M, Kitagawa K, Mochizuki H
- Journal Title
  
  Neuroscience
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390222
[Journal Article] Neuroaxonal dystrophy in PLA2G6 knockout mice2015
- Author(s)
  Sumi H, Beck G, Kato S, Mochizuki H
- Journal Title
  
  Neuropathology
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591294
[Journal Article] The role of gut microbiota and diet in EAE and MS2015
- Author(s)
  奥野、木下、中辻、望月
- Journal Title
  
  Clinical & Experimental Neuroimmunology
  
  Volume: 6 Issue: S1 Pages: 30-37
- DOI
  10.1111/cen3.12270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461293
[Journal Article] Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora2015
- Author(s)
  Takata K,　Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: ２ Issue: 1 Pages: 56-66
- DOI
  10.1002/acn3.153
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860712, KAKENHI-PROJECT-26461293
[Journal Article] Synchrotron FTIR Micro-Spectroscopy for Structural Analysis of Lewy Bodies in the Brain of Parkinson’s Disease Patients2015
- Author(s)
  K. Araki, N. Yagi, Y. Ikemoto, S. Choong, H. Hayakawa, G. Beck, H. Sumi, H. Fujimura, T. Moriwaki, Y. Nagai, Y. Goto and H. Mochizuki
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 17625-17625
- DOI
  10.1038/srep17625
- NAID
  120006557628
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05142, KAKENHI-PUBLICLY-15H01558, KAKENHI-PROJECT-15H04362, KAKENHI-PROJECT-15K14339, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26293210
[Journal Article] Chronic Elevation of Tumor Necrosis Factor-α Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice.2015
- Author(s)
  Yukami T, Yagita Y, Sugiyama Y, Oyama N, Watanabe A, Sasaki T, Sakaguchi M, Mochizuki H, Kitagawa K.
- Journal Title
  
  Stroke
  
  Volume: 46 Issue: 6 Pages: 1657-63
- DOI
  10.1161/strokeaha.114.008062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04844, KAKENHI-PROJECT-24390222
[Journal Article] 11C-Acetate PET Imaging in Patients with Multiple Sclerosis.2014
- Author(s)
  Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 11 Pages: e111598-e111598
- DOI
  10.1371/journal.pone.0111598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249077, KAKENHI-PROJECT-25860712, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-26462204
[Journal Article] Granulocyte colony-stimulating factor fails to enhance leptomeningeal collateral growth in spontaneously hypertensive rats2014
- Author(s)
  Sugiyama Y, Yagita Y, Yukami T, Watanabe A, Oyama N, Terasaki Y, Omura-Matsuoka E, Sasaki T, Mochizuki H, Kitagawa K
- Journal Title
  
  Neurosci Lett
  
  Volume: 564 Pages: 16-20
- DOI
  10.1016/j.neulet.2014.01.053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390234, KAKENHI-PROJECT-24591260, KAKENHI-PROJECT-24390222
[Journal Article] Partial suppression of M1microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosi2014
- Author(s)
  Tada S, Okuno T, Hitoshi Y, Yasui T, Honorat J, Takata K, Koda T, Shimagami H, Chi-Jing C, Namba A,Sugimoto T, Sakoda S, Mochizuki H, Kikutani H, Nakatsuji Y
- Journal Title
  
  J Neuroinflammation
  
  Volume: 11 Issue: 1 Pages: 179-179
- DOI
  10.1186/s12974-014-0179-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461293
[Journal Article] The promises of stem cells: stem cell therapy for movement disorders.2014
- Author(s)
  Mochizuki H, Choong CJ, Yasuda T.
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 20 Suppl 1 Pages: 43-9
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Lewy body pathology in a patient with a homozygous parkin deletion. Lewy body pathology in a patient with a homozygous parkin deletion2013
- Author(s)
  Miyakawa S., 他12名, *Mochizuki H.
- Journal Title
  
  Movement Disorder
  
  Volume: 28(3) Pages: 388-91
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] PLA2G6(PARK14)遺伝子欠損に伴う軸索変性の病態2013
- Author(s)
  隅寿恵, 別宮豪一, 望月秀樹
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 1061-1068
- Data Source
  KAKENHI-PROJECT-24591294
[Journal Article] Functional deterioration of endothelial nitric oxide synthase after focal cerebral ischemia2013
- Author(s)
  Yagita Y, Kitagawa K, Oyama N, Yukami T, Watanabe A, Sasaki T, Mochizuki H
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 33 Issue: 10 Pages: 1532-9
- DOI
  10.1038/jcbfm.2013.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390234, KAKENHI-PROJECT-24390222, KAKENHI-PROJECT-24591260
[Journal Article] BAFF controls neural cell survival through BAFF receptor.2013
- Author(s)
  Tada S, Yasui T, Nakatsuji Y, Okuno T, Koda T, Mochizuki H, Sakoda S, Kikutani H
- Journal Title
  
  PLoS One.
  
  Volume: 28;32(48)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.2013
- Author(s)
  Honorat JA, Kinoshita M, Okuno T, Takata K, Koda T, Tada S, Shirakura T, Fujimura H, Mochizuki H, Sakoda S, Nakatsuji Y.
- Journal Title
  
  PLoS One.
  
  Volume: 8(7)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination.2013
- Author(s)
  Takahashi C, Muramatsu R, Fujimura H, Mochizuki H, Yamashita T.
- Journal Title
  
  Cell Death Dis
  
  Volume: 12;4
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin.2012
- Author(s)
  Muramatsu R., Takahashi C., Miyake S., Fujimura H., Mochizuki H., Yamashita T.
- Journal Title
  
  Nature Medicine
  
  Volume: 18(11) Pages: 1658-64
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Accumulation of α-synuclein triggered by presynaptic dysfunction.2012
- Author(s)
  Nakata Y., 他11名, Mochizuki H.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 32(48) Pages: 17186-96
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of interferon-beta therapy in multiple sclerosis.2012
- Author(s)
  Nakatsuji Y., Okuno T., 17名, Mochizuki H., Kumanogoh A.
- Journal Title
  
  Journal of Immunology
  
  Volume: 188(10) Pages: 4858-4865
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] Sonographic guidance provides a low-risk approach to the longus colli muscle.2012
- Author(s)
  Fujimoto H., Mezaki T., Yokoe M., Mochizuki H.
- Journal Title
  
  Movement Disorder
  
  Volume: 27(7) Pages: 928-9
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111531
[Journal Article] AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice2007
- Author(s)
  Kawakami, T., Kanazawa, H., Satoh, T., Ieda, M., Ieda, Y., Kimura, K., Mochizuki, M., Shimada, T., Yokoyama, C., Ogawa, S., Tanabe, T., Fukuda, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 363
  
  Pages: 656-661
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390305
[Journal Article] Neuronal specificity of α-synuclein toxicity and effect of Parkin co-expression in primates2007
- Author(s)
  Yasuda, T., Miyachi, S., Kitagawa, R., Wada, K., Nihira, T., Ren, Y.-R., Hirai, Y., Ageyama, Y., Terao, K., Shimada, T., Takada, M., Mizuno, Y., Mochiduki, H.
- Journal Title
  
  Neuroscience 144
  
  Pages: 743-745
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390305
[Journal Article] The isolation of neural stem cells from olfactory bulb of Parkinson's disease model.2007
- Author(s)
  Hayakawa, H・Hayashita-Kinoh, H・Nihira, T・Mizuno, Y・Mochizuki, H
- Journal Title
  
  Neurosci Res 57
  
  Pages: 393-398
- NAID
  10024413286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun Mar 24; 341(4)
  
  Pages: 1088-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun. Mar 24;341(4)
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the subatantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H
- Journal Title
  
  Biochem Biophys Res Commun. Mar24;341(4)
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal Hydrolase L1 in water by small-angle neutron scattering.2006
- Author(s)
  Naito S, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu H, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K
- Journal Title
  
  Biochem Biophys Res Commun 339(2)
  
  Pages: 717-725
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.2006
- Author(s)
  Hayashita-Kinoh H, Yamada M, Yokota T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Biochem Biophys Res Commun. 341(4)
  
  Pages: 1088-1095
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Ex vivo cell-mediated gene therapy for metachromatic leukodystrophy using neurospheres2006
- Author(s)
  Kawabata, K., Migita, M., Mochizuki, H., Miyake, K., Igarashi, T., Fukunaga, Y., Shimada, T.
- Journal Title
  
  Brain Res. 1094
  
  Pages: 13-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390305
[Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal Hydrolase L1 in water by small-angle neutron scattering.2006
- Author(s)
  Naito S, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Ikeda S, Adachi T, Shimizu H, Suzuki J, Fujiwara S, Okada T, Nishikawa K, Aoki S, Wada K
- Journal Title
  
  Biochem Biophys Res Commun 339(2)
  
  Pages: 717-725
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci Jan; 21(2)
  
  Pages: 317-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci. Jan;21(2)
  
  Pages: 317-326
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul;58(1)
  
  Pages: 31-40
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb;16(2)
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Parkin Gene Therapy for α-Synucleinopathy : A Rat Model of Parkinson's disease2005
- Author(s)
  Yamada M, Mizuno Y, Mochizuki H
- Journal Title
  
  Hum Gene Therapy 16
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. 58(1)
  
  Pages: 31-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Human Gene Therapy 16
  
  Pages: 262-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb; 16(2)
  
  Pages: 262-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] The fate of neural progenitor cells expressing astrocytic and glial markers in the postnatal rat dentate gyrus.2005
- Author(s)
  Namba T, Mochizuki H, Onodera M, Mizuno Y, Namiki H, Seki T
- Journal Title
  
  Eur J Neurosci. Oct;22(8)
  
  Pages: 1928-1941
- Data Source
  KAKENHI-PROJECT-17659268
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul; 58(1)
  
  Pages: 31-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Parkin inhibits alpha-synucleinopathy in rat substantia nigra.2005
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Hum Gene Ther. Feb;16(2)
  
  Pages: 262-270
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Possibility for Neurogenesis in Substantia Nigra of Parkinsonian2005
- Author(s)
  Yoshimi K, Young RR, Mizuno Y, Mochizuki H, et al.
- Journal Title
  
  Ann Neurol 58
  
  Pages: 58-31
- Data Source
  KAKENHI-PROJECT-17025037
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R.
- Journal Title
  
  Eur J Neurosci. Jan;21(2)
  
  Pages: 317-326
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.2005
- Author(s)
  Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H. Mizuno Y, Katsube N, Ishitani R
- Journal Title
  
  Eur J Neurosci. 21(2)
  
  Pages: 317-326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Possibility for neurogenesis in substantia nigra of parkinsonian brain.2005
- Author(s)
  Yoshimi K, Ren YR, Seki T, Yamada M, Ooizumi H, Onodera M, Saito Y, Murayama S, Okano H, Mizuno Y, Mochizuki H.
- Journal Title
  
  Ann Neurol. Jul;58(1)
  
  Pages: 31-40
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Functional Effects of NAD(P)H Oxidase p22phox C242T Mutation in Human Leukocytes and Association with Thrombotic Cerebral Infarction.2004
- Author(s)
  Shimo Y, Hasebe T, Suzuki A, Mochizuki H, Tanaka Y, Nagaoka I, Mizuno Y, Urabe T.
- Journal Title
  
  Atherosclerosis: 175
  
  Pages: 109-115
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Neurogenesis After Transient Global Ischemia in the Adult Hippocampus Visualized by Improved Retroviral Vector.2004
- Author(s)
  Tanaka R, Yamashiro K, Mochizuki H, Cho N, Onodera M, Mizuno Y, Ur
- Journal Title
  
  Stroke. 35(6)
  
  Pages: 1454-1459
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice.2004
- Author(s)
  Yamada M, Onodera M, Mizuno Y, Mochizuki H.
- Journal Title
  
  Neuroscience. 124
  
  Pages: 173-181
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1b, and expression of caspase-11 in mice.2004
- Author(s)
  Arai H, Furuya T, Miura M, Mizuno Y, Mochizuki H.
- Journal Title
  
  J Biol Chem 79
  
  Pages: 51647-51653
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Dual role of Fcgamma receptor in transient focal cerebral ischemia in mice.2004
- Author(s)
  Komine M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T.
- Journal Title
  
  Stroke 35(4)
  
  Pages: 958-963
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase2004
- Author(s)
  Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H.
- Journal Title
  
  Neurochem 91
  
  Pages: 451-161
- Data Source
  KAKENHI-PROJECT-16390255
[Journal Article] Migration of EGFP expressing bone marrow-derived microglia/macrophage into the mice brain following permanent focal ischemia.2003
- Author(s)
  Tanaka, R., Komine-Kobayashi, M., Mochizuki, H., Yamada, M., Furuya, T., Migita, M., Shimada, T., Mizuno, Y., Urabe, T.
- Journal Title
  
  Neuroscience 117
  
  Pages: 531-539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta-cells.2003
- Author(s)
  Choi, J.B., Uchino, H., Azuma, K., Iwashita, N., Tanaka, Y., Mochizuki, H., Migita, M., Shimada, T., Kawamori, R., Watada, H.
- Journal Title
  
  Diabetologia 46
  
  Pages: 1366-1374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders.2003
- Author(s)
  Furuya, T., Tanaka, R., Urabe, T., Hayakawa, J., Migita, M., Shimada, T., Mizuno, Y., Mochizuki, H.
- Journal Title
  
  NeuroReport 14
  
  Pages: 629-631
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Adeno-associated virus mediated antiapoptotic gene delivery; in vivo gene therapy for neurological disorders.2002
- Author(s)
  Mochizuki, H., Miura, M., et al.
- Journal Title
  
  Methods 28
  
  Pages: 248-252
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Adeno-associated virus mediated antiapoptotic gene delivery : in vivo gene therapy for neurological disorders.2002
- Author(s)
  Mochizuki, H., Miura, M., Shimada, T., Mizuno, Y.
- Journal Title
  
  Methods 28
  
  Pages: 248-252
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Anti-apoptotic therapy for Parkinson's disease: overexpression of an apf-1-dominant-gnegative inhibitor can block MPTP toxicity. Mapping the Program of Alzheimer's and Parkinson's Disease. (edited by Mizuno et al.)2002
- Author(s)
  Mochizuki, H., Hayakawa, H., et al.
- Journal Title
  
  Kluwer Academic Publishers
  
  Pages: 469-472
- Data Source
  KAKENHI-PROJECT-14370253
[Journal Article] Adeno-associated virus mediated antiapoptotic gene delivery : in vivo gene therapy for neurological disorders.2002
- Author(s)
  Mochizuki, H., et al.
- Journal Title
  
  Methods 28
  
  Pages: 248-252
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370253
[Patent] パーキンソン病モデル非ヒト動物2018
- Inventor(s)
  望月　秀樹、馬場　孝輔、早川　英規
- Industrial Property Rights Holder
  望月　秀樹、馬場　孝輔、早川　英規
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02741
[Patent] 含窒素複素環誘導体、神経保護剤及びがん治療用医薬組成物2015
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-09
- Overseas
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アシルアミノフェニル基を有する化合物及びその用途2015
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、住吉孝之
- Industrial Property Rights Type
  特許
- Filing Date
  2015-11-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アイソフォーム特異的新規 HDAC 阻害剤による神経疾患治療法の開発2014
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一、平田佳之
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一、平田佳之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-183239
- Filing Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] アシルアミノフェニル基を有する化合物及びその用途2014
- Inventor(s)
  佐々木勉、望月秀樹、Choong CJ、上里新一
- Industrial Property Rights Holder
  佐々木勉、望月秀樹、Choong CJ、上里新一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-237826
- Filing Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24390222
[Patent] 新規含窒素複素環誘導体2014
- Inventor(s)
  上里新一、住吉孝明、平田佳之、望月秀樹、佐々木勉
- Industrial Property Rights Holder
  上里新一、住吉孝明、平田佳之、望月秀樹、佐々木勉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-183235
- Filing Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Is Parkinson’s disease systemic amyloidosis?2019
- Author(s)
  Hideki Mochizuki
- Organizer
  TOWARDS A CURE FOR AMYLOID DISEASES: A SUCCESSFUL EXAMPLE OF PRECISION AND TRANSLATIONAL MEDICINE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02741
[Presentation] Small-molecule inhibitors of p53/negative regulator-interaction protect dopaminergic neurons against MPP+/MPTP-induced neurotoxicity.2017
- Author(s)
  Choong CJ, Sasaki T, Hayakawa H, Baba K, Hirata Y, Uesato S, Mochizuki H.Small-molecule inhibitors of p53/negative regulator-interaction protect dopaminergic neurons against MPP+/MPTP-induced neurotoxicity.
- Organizer
  XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Presentation] Antisense oligonucleotides containing amido-bridged nucleic acid downregulate SNCA expression and improve motor function in Parkinson's disease mouse models.2017
- Author(s)
  Takuya Uehara, Chi-Jing Choong, Hideki Hayakawa, Yuuya Kasahara, Tetsuya Nagata, Takanori Yokota, Kousuke Baba, Masayuki Nakamori, Satoshi Obika, Hideki Mochizuki.
- Organizer
  MDS 2017 Vancouver, BC, Canada　Vancouver Convention Centre VANCOUVER JUNE 4-8 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Presentation] Small-molecule inhibitors of p53/negative regulator-interaction protect dopaminergic neurons against MPP+/MPTP-induced neurotoxicity2017
- Author(s)
  Choong CJ, Sasaki T, Hayakawa H, Baba K, Hirata Y, Uesato S, Mochizuki H.
- Organizer
  XXIII World Congress of Neurology, Kyoto, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17413
[Presentation] Structural variations in alpha synuclein (αSyn) fibrils of Parkinson’s disease and related disorders.2017
- Author(s)
  Kensuke Ikenaka, Katsuya Araki, Masatomo So, Cesar Aguirre, Kousuke Baba, Yuji Goto, Hideki Mochizuki.
- Organizer
  American Neurological Association 2017 SAN DIEGO OCTOBER 15-17 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Presentation] A novel method for behavioral assessments of the common marmoset Marmodetector, detects general natural movement and changes in motor behavior.2017
- Author(s)
  Taiki Yabumoto, Fumiaki Yoshida, Kousuke Baba, Hideki Hayakawa, Hiroki Hamanaka, Masayuki Hirata, Hideki Mochizuki.
- Organizer
  XXIII World Congress of Neurology (WCN 2017), Kyoto, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Presentation] Gapmer型Amido-bridged nucleic acids搭載核酸医薬によるα-シヌクレイン抑制の検討.2017
- Author(s)
  上原拓也, Choong Chi-Jing, 早川英規, 笠原勇矢, 永田哲也, 横田隆徳, 馬場孝輔, 中森雅之, 小比賀聡, 望月秀樹.
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス　2017年10月　東京
- Data Source
  KAKENHI-PUBLICLY-17H05700
[Presentation] Selective inhibition of NR2B attenuates ischemic neuronal injury in neuronal culture and rats2016
- Author(s)
  Terasaki Y, Sasaki T, Yukami T, Oyama N, Yagita Y, Sakaguchi M, Kitagawa K, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 多発性硬化症患者における血清Sema4A値高値群の臨床的特徴．2016
- Author(s)
  南波明子，山下和哉，甲田亨，奥野龍禎，熊ノ郷淳，中辻裕司，望月秀樹．
- Organizer
  57回日本神経学会学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 多発性硬化症患者における血清Sema4A高値群の臨床的特徴と、IFN-β開始後5年間のNEDA達成率．2016
- Author(s)
  南波明子，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，熊ノ郷淳，中辻裕司，望月秀樹
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] Novel HDAC1/2 isoform-specific inhibitor K560 ameliorates MPP+/MPTP-mediated experimental Parkinson’s disease2016
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  AOPMC 2016 (5th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress)
- Place of Presentation
  MANILA, PHILIPPINES
- Year and Date
  2016-03-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 多発性硬化症治療選択バイオマーカーＳｅｍａ４Ａ～フィンゴリモドとの相関について2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深沢俊行、南波明子，山下和哉、清水幹人、熊ノ郷淳、佐古田三郎、望月秀樹．
- Organizer
  第28回　日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] Serine racemase inhibition induces NO-mediated neurovascular protection during cerebral ischemia2016
- Author(s)
  Watanabe A, Sasaki T, Kanki H, Yukami T, Takemori H, Sakaguchi M, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Effect of thrombin and cAMP-PKA signaling on the angiogenesis in brain microvasculature2016
- Author(s)
  Kanki H, Sasaki T, Watanabe A, Yukami T, Sakaguchi M, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] The structure analysis for alpha-synuclein and Lewy bodies with synchrotron radiation.2016
- Author(s)
  Katsuya Araki, Naoto Yagi, Rie Nakatani, Hideki Hayakawa, Kousuke Baba, Yuji Goto, Hideki Mochizuki.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] NMOsdにおいて血中Sema4Aは増加する2016
- Author(s)
  榊原佳織，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，深沢俊行，熊ノ郷淳，望月秀樹　中辻裕司．
- Organizer
  第28回　日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 放射光顕微赤外分光法を用いた剖検脳のグリア細胞内嗜銀性封入体の構造解析．2016
- Author(s)
  荒木克哉，八木直人，池中健介，早川英規，永井義隆，藤村晴俊，望月秀樹．
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都ホテルオークラ
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] The structure analysis for alpha-synuclein and Lewy bodies of Parkinson's disease patients with synchrotron radiation.2016
- Author(s)
  Katsuya Araki, Naoto Yagi, Rie Nakatani, Hideki Hayakawa, Kousuke Baba, Yuji Goto, Hideki Mochizuki.
- Organizer
  5th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress (AOPMC)
- Place of Presentation
  Manila, Philippines
- Year and Date
  2016-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] Efficacy and implications of isoform selective Histone deacetylase inhibitors for cerebral ischemia2016
- Author(s)
  Sasaki T, Chonng Chi-Jing, Watanabe A, Kanki H, Yukami T, Hayakawa H, Yasuda T, Baba K, Sakaguchi M, Uesato S, Mochizuki H
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] The structure analysis for alpha-synuclein and Lewy bodies of Parkinson's disease patients with synchrotron radiation2016
- Author(s)
  Katsuya Araki, Naoto Yagi, Rie Nakatani, Hideki Hayakawa, Kosuke Baba, Hideki Mochizuki,
- Organizer
  5th AOPMC
- Place of Presentation
  マニラ（フィリピン）
- Year and Date
  2016-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14339
[Presentation] 脳虚血におけるSRR-Serineの役割について2015
- Author(s)
  渡邊　彰弘、佐々木　勉、神吉　秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.2015
- Author(s)
  Chi-Jing Choong, Tsutomu Sasaki, Hideki Hayakawa, Toru Yasuda, Kousuke Baba, Yoshiyuki Hirata, Shinichi Uesato, and Hideki Mochizuki
- Organizer
  XXI World Congress on Parkinson’s Disease and Related Disorders. IAPRD 2015
- Place of Presentation
  Milan, Italy
- Year and Date
  2015-12-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Loss of calcium-independent phospholipase A2β causes degeneration of mitochondrial and presynaptic membranes in neurons2015
- Author(s)
  Goichi Beck, Hisae Sumi-Akamaru, Koei Shinzawa, Yuki Sugiura, Mitsutoshi Setou, Yoshihide Tsujimoto, and Hideki Mochizuki
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Year and Date
  2015-02-11
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] Efficacy and implications of selective class I or II Histone deacetylase inhibitors for neurological disorders.2015
- Author(s)
  CJ Choong, T Sasaki, H Hayakawa, K Baba, Watanabe A, Y Hirata, S Uesato and H Mochizuki
- Organizer
  17th Annual Meeting of the American Society for Experimental NeuroTherapeutics (ASENT 2015)
- Place of Presentation
  Georgetown University Hotel And Conference Center, District of Columbia, Washington, USA
- Year and Date
  2015-02-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるPGC-1αシグナルの調節機構の検討2015
- Author(s)
  佐々木勉、渡邊　彰弘、神吉　秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Necdin promotes mitochondrial biogenesis to prevent neurodegeneration in experimental Parkinson's disease2015
- Author(s)
  Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Mochizuki H, Yoshikawa K
- Organizer
  Neuroscience 2015, Society for Neuroscience
- Place of Presentation
  Chicago（USA)
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24300134
[Presentation] The structure analysis for alpha-synuclein and Lewy bodies with synchrotron radiation.2015
- Author(s)
  Katsuya Araki, Naoto Yagi, Rie Nakatani, Hideki Hayakawa, Kousuke Baba, Yuji Goto, Hideki Mochizuki.
- Organizer
  第56回　日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] パーキンソン病の新しい治療に向けて　～凝集阻害因子のハイスループットスクリーニング～2015
- Author(s)
  荒木克哉，薮本大紀，宗正智，馬場孝輔，後藤祐児，望月秀樹
- Organizer
  第33回　日本神経治療学会
- Place of Presentation
  名古屋
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] Structure analysis of post-translationally modified alpha-synuclein by small angle X-ray scattering (SAXS)2015
- Author(s)
  Katsuya Araki, Naoto Yagi, Rie Nakatani, Hisashi Yagi, Yuji Goto, Hideki Mochizuki
- Organizer
  第56回神経学会総会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K14339
[Presentation] Promotion of neuronal mitochondiral biogenesis by necdin: Neuroprotection in experimental Parkinsonism2015
- Author(s)
  吉川和明, 長谷川孝一, 安田徹, 望月秀樹
- Organizer
  第３８回　日本神経科学会大会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2015-07-29
- Invited
- Data Source
  KAKENHI-PROJECT-24300134
[Presentation] アイソフォーム特異的HDAC阻害剤による虚血性脳血管障害の治療検討2015
- Author(s)
  佐々木　勉、鐘　其静、渡邊　彰弘、神吉　秀明、馬場　孝輔、平田　佳之、坂口　学、上里　新一、望月　秀樹
- Organizer
  第33回日本神経治療学会総会 The 33rd Annual Meeting of Japanese Society of Neurological Therapeutics
- Place of Presentation
  名古屋
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるCRTC-PGC-1αシグナルの動態についての検討2014
- Author(s)
  佐々木　勉、渡邊彰弘、神吉秀明、由上登志郎、竹森　洋、坂口　学、望月秀樹
- Organizer
  第51回日本臨床分子医学会総会
- Place of Presentation
  東京国際フォーラム、東京都千代田区
- Year and Date
  2014-04-11
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Neuroaxonal dystrophy in PLA2G6 gene knockout mice2014
- Author(s)
  Hisae Sumi-Akamaru, Goichi Beck, Hideki Mochizuki
- Organizer
  第55回日本神経病理学会総会学術研究会
- Place of Presentation
  Tokyo
- Year and Date
  2014-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] Structure and function of α-synuclein2014
- Author(s)
  望月秀樹
- Organizer
  日本神経科学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-26293210
[Presentation] PLA2G6遺伝子ノックダウンによるαシヌクレインの細胞内動態2014
- Author(s)
  別宮豪一、隅寿恵、新沢康英、早川英規、辻本賀英、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6（Park14）遺伝子欠損マウスにおける神経変性のメカニズム2014
- Author(s)
  望月秀樹、隅寿恵、別宮豪一、新沢康英、辻本賀英
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] ニコチン性アセチルコリン受容体活性化による神経保護作用の検討2014
- Author(s)
  佐々木勉、北川一夫、渡邉彰弘、竹森　洋、渡邊　彰弘、由上登志郎、竹森　洋、望月秀樹
- Organizer
  日本脳卒中学会(Stroke2014)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血時のCRTC-PGC-1αシグナルの動態2014
- Author(s)
  佐々木　勉、北川一夫、八木田佳樹、由上登志郎、佐野坂真人、八木田佳樹、竹森　洋、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場、福岡県福岡市博多区
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 脳虚血におけるCRTC-PGC-1αシグナルの動態についての検討2014
- Author(s)
  佐々木勉、竹森　洋、渡邊　彰弘、由上登志郎、北川一夫、望月秀樹
- Organizer
  臨床分子医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] プロスタグランジンI2 アゴニストであるONO-1301はALSモデル動物の神経変性を抑制する。2014
- Author(s)
  多田智、安居輝人、奥野龍禎、中辻裕司、酒井芳紀、宮川繁、澤芳樹、菊谷仁、佐古田三郎、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 2型糖尿病では脳軟膜動脈吻合の発達は障害される2014
- Author(s)
  由上登志郎、八木田佳樹、渡邊彰弘、佐々木勉、坂口学、望月秀樹、北川一夫
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場、福岡県福岡市博多区
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] 血清Sema4A増加を示すNMO spectrum disordersの臨床的特徴の解析2014
- Author(s)
  奥野龍禎、甲田亨、宮本勝一、中辻裕司、高田和城、オノラジョセフ、木下允、楠進、熊ノ郷淳、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] Efficacy and implications of selective class I or II Histone deacetylase inhibitors for ischemic brain injury.2014
- Author(s)
  Sasaki T, Choong CJ, Watanabe A, Hirata Y, Sanosaka M, Yukami T, Kitagawa K, Takemori H, Uesato S, Mochizuki H.
- Organizer
  American Neurological Association's 2014 Annual Meeting
- Place of Presentation
  Baltimore Marriott Waterfront Hotel, Maryland, USA
- Year and Date
  2014-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Neuroaxonal dystrophy in the striatum of PLA2G6 knockout mice2014
- Author(s)
  隅寿恵、別宮豪一、伊藤朝子、新沢康英、加藤信介、辻本賀英、佐古田三郎、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] BAFF controls neural cell survival through BAFF receptor2013
- Author(s)
  ada S, Yasui T, Nakatsuji Y, Okuno T, Mochizuki H, Sakoda S, Kikutani H.
- Organizer
  XXI WORLD CONGRESS OF NEUROLOGY
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] The Promises of Stem Cells2013
- Author(s)
  Hideki Mochizuki
- Organizer
  World Congress on Parkinson’s Disease and Related disorders
- Place of Presentation
  Geneva Switzerland
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] T LYMPHOCYTES CONTROL MICROGLIAL ACTIVATION THROUGH CD40 IN NEURODEGENERATIVE DISEASES2013
- Author(s)
  Tatsusada Okuno, Hideki Mochizuki
- Organizer
  World Congress on Parkinson’s Disease and Related disorders
- Place of Presentation
  Geneva Switzerland
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) over primary foot motor area in Parkinson's disease (PD)2013
- Author(s)
  Yokoe M Maruo T Saitoh Y Mochizuki H
- Organizer
  SENT 15th Annual Meeting
- Place of Presentation
  Washington DC USA
- Year and Date
  2013-03-11
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] A Role of CREB-CRTC signaling in nicotine-induced neuroprotection.2013
- Author(s)
  T Sasaki, K Kitagawa, A Watanabe, T Yukami, N Oyama, Y Yagita, H Takemori, and H Mochizuki
- Organizer
  Brain 2013
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] ニコチンによる神経保護機構の検討2013
- Author(s)
  佐々木勉、北川一夫、渡邊彰弘、由上登志郎、八木田佳樹、竹森　洋、望月秀樹
- Organizer
  第54回日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390222
[Presentation] Cell cycle regulation promotes survival of dopaminergic neurons in experimental Parkinson disease2012
- Author(s)
  Toru Yasuda, Kazuaki Yoshikawa, Serge Przedborski, Yoshikuni Mizuno, Hideki Mochizuki
- Organizer
  The Movement Disorder Society’s 16th International Congress of Parkinson’s Disease and Movement Disorders
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2012-06-17
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] パーキンソン病の炎症機転におけるCD40 の役割2012
- Author(s)
  奥野龍禎中辻裕司　望月秀樹
- Organizer
  第6回パーキンソン病運動障害疾患コングレス
- Place of Presentation
  京都
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] Brain iron accumulation in calcium-independent phospholipase A2 beta knockout mice
- Author(s)
  Goichi Beck, Hisae Sumi-Akamaru, Koei Shinzawa, Toru Yasuda, Yoshihide Tsujimoto, Hideki Mochizuki
- Organizer
  Twenty-third Meeting of the European Neurological Society
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] 筋委縮性側索硬化症の脊髄白質におけるリン酸化TDP-43の局在
- Author(s)
  隅　寿恵、別宮　豪一、加藤　信介、山寺　みさき、藤村　晴俊、望月　秀樹
- Organizer
  第53回日本神経病理学会総会学術研究会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6遺伝子欠損マウス脳におけるtyrosine hydroxylase陽性異常構造物の経時的変化
- Author(s)
  別宮豪一、隅寿恵、新沢康英、安田徹、辻本賀英、佐古田三郎、望月秀樹
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] Necdinによるニューロン内ミトコンドリア機能の促進：パーキンソン病モデルにおける神経保護作用
- Author(s)
  長谷川孝一、安田徹、白石千夏、藤原一志郎、望月秀樹、吉川和明
- Organizer
  第57回日本神経化学会大会
- Place of Presentation
  奈良県文化会館 (奈良市)
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24300134
[Presentation] PLA2G6遺伝子欠損マウス線条体におけるドパミン神経終末マーカーの変化
- Author(s)
  隅寿恵、別宮豪一、新沢康英、早川英規、辻本賀英、望月秀樹
- Organizer
  第7回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] Recent progress in multiple system atrophy
- Author(s)
  望月秀樹
- Organizer
  日本神経学会学術集会
- Place of Presentation
  東京フォーラム
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] PLA2G6遺伝子欠損マウス脊髄におけるユビキチン陽性構造物と軸索変性
- Author(s)
  隅寿恵、別宮豪一、新沢康英、加藤信介、佐古田三郎、辻本賀英、望月秀樹
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6遺伝子欠損マウス脊髄神経細胞における異常ミトコンドリアとユビキチン陽性の変性軸索の関係
- Author(s)
  隅寿恵、別宮豪一、新沢康英、加藤信介、佐古田三郎、辻本賀英、望月秀樹
- Organizer
  第54回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] Neuroinflammation in Parkinson’s Disease
- Author(s)
  望月秀樹
- Organizer
  日本神経免疫学会
- Place of Presentation
  下関　山口
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111531
[Presentation] Involvement of Sema4A in multiple sclerosis and neuromyelitis optica.
- Author(s)
  Tatsusada Okuno, Toru Koda, Katsuichi Miyamoto, Kazushiro Takata, Josephe A. Honorat, Susumu Kusunoki, Atsushi Kumanogoh, Yuji Nakatsuji, Hideki Mochizuki.
- Organizer
  The 12th International Congress of Neuroimmunology.
- Place of Presentation
  Ｍainz, Ｇermany
- Year and Date
  2014-11-09 – 2014-11-13
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] iPLA2β遺伝子欠損マウス脳における鉄沈着および軸索変性との関連性の検討
- Author(s)
  別宮　豪一、隅　寿恵、白井　良樹、安田　徹、新沢　康英、辻本　賀英、望月　秀樹
- Organizer
  第53回日本神経病理学会総会学術研究会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6遺伝子欠損マウスにおけるドパミン作動性神経系の変性
- Author(s)
  別宮　豪一、隅　寿恵、新沢　康英、加藤　信介、安田　徹、辻本　賀英、望月　秀樹
- Organizer
  第6回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] iPLA2β遺伝子欠損マウス脳における鉄沈着および軸索変性との関連性の検討
- Author(s)
  白井　良樹、別宮　豪一、隅　寿恵、新沢　康英、安田　徹、辻本　賀英、望月　秀樹
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6遺伝子欠損マウス脊髄におけるリン酸化αシヌクレインの蓄積
- Author(s)
  隅　寿恵、別宮　豪一、加藤　信介、新沢　康英、安田　徹、辻本　賀英、佐古田　三郎、望月　秀樹
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591294
[Presentation] PLA2G6遺伝子欠損マウスにおけるリン酸化αシヌクレインの神経細胞内蓄積と軸索内輸送
- Author(s)
  隅　寿恵、別宮　豪一、新沢　康英、加藤　信介、安田　徹、辻本　賀英、佐古田　三郎、望月　秀樹
- Organizer
  第6回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591294

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MOCHIDUKI Hideki 望月 秀樹

望月 秀樹 モチヅキ ヒデキ

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Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid FibrilsPrincipal Investigator

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Elucidate the pathomechanisms of alpha synuclein polymorphinsms imparts disease dievrsitiesPrincipal Investigator

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Development of biomarker and new therapy using the protein structurePrincipal Investigator

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Generation of a new mouse model using neurons derived from iPS cells of Parkinson's disease patientsPrincipal Investigator

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Deciphering molecular mechanisms underlying the unconventional extracellular mitochondria releasePrincipal Investigator

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パーキンソン病マーモセットにおけるiPS由来α-Syn蛋白伝播Principal Investigator

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Structure and function analysis of alpha-synuclein in Parkinson's diseasePrincipal Investigator

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変性疾患における神経細胞、ミクログリアの相互作用、インフラマゾームを中心にPrincipal Investigator

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MOCHIDUKI Hideki 望月秀樹

望月秀樹モチヅキヒデキ