MATSUMOTO Yotato 松本洋太郎

… Alternative Names

MATSUMOTO Yotaro 松本洋太郎

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Researcher Number	90420041
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北大学, 薬学研究科, 講師 2017: 東北大学, 大学院薬学研究科, 講師 2013: 帝京大学, 薬学部, 講師 2012 – 2013: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Chemical pharmacy Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical Physics and Radiological Technology / Tumor diagnostics / Drug development chemistry
Keywords	Principal Investigator バイオマーカー / プロファイリング / LC-MS/MS / 修飾ヌクレオシド / 修飾核酸 / 安定同位体 / がん診断法 / 一斉定量 / ROC曲線 / 肺がん … More / LC-MS / 有機合成 / 重水素化 / ターゲットメタボロミクス / 定量系 / ニコチンアミドアデニンジヌクレオチド / サイクリックADPリボース / Meisenheimer 型中間体 / 遷移構造 / 反応機構解析 / SNAr / 位置選択性 / 構造最適化 / マイゼンハイマー型中間体 / 量子化学計算 / 芳香族求核置換反応 … More Except Principal Investigator スフィンゴ脂質 / 質量分析計 / MSイメージング / MALDI / S1P / CD73 / メタボロミクス / アデノシン / 細胞外小胞 / 誘導体化 / 一細胞 / MSイメージング法 / 免疫制御 / ＣＤ３９ / ＣＤ７３ / 免疫抑制 / 化合物ライブラリー / エクソソーム / compound library / inhibitors / CD39 / がん細胞 / 脂肪酸合成酵素 / プロテオミクス / 放射線耐性 / 腫瘍マーカー / LC/MS / がん免疫 / 修飾核酸 / 変異ロドプシン / 網膜色素変性症 / 酵素阻害剤 / ニーマン・ピック病Ｃ型 / 膜タンパク質 / 蛋白質相互作用 / 生理活性物質 / 核内受容体リガンド / マルチテンプレート / 蛋白変性症 / フォールディング異常症 / トラフィッキング Less

投影型MSイメージング法による脂質ラフト含有スフィンゴ脂質の可視化技術開発
- Principal Investigator
  
  三枝大輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Teikyo University
Development of cancer diagnostic method based on modified nucleoside profilingPrincipal Investigator
- Principal Investigator
  
  松本洋太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Development of modified nucleoside profiling methods in precision medicinePrincipal Investigator
- Principal Investigator
  
  Matsumoto Yotaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tohoku University
Distribution analysis of S1P on tissue sections by high resolution MS imaging
- Principal Investigator
  
  Saigusa Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Teikyo University
  Tohoku University
Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery
- Principal Investigator
  
  Tomioka Yoshihisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Construction of highly sensitive quantitative system of cADPR for comprehensive evaluation of NAD-related metabolitesPrincipal Investigator
- Principal Investigator
  
  Matsumoto Yotaro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tohoku University
Investigation of the modified nucleic acid for novel cancer evaluation marker candidates and its diagnostic application.
- Principal Investigator
  
  Tomioka Yoshihisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tohoku University
Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.
- Principal Investigator
  
  Kanemitsu Yoshitomi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical Physics and Radiological Technology
- Research Institution
  Tohoku University
A Theoretical Study of p-Deficient System Aromatic Nucleophlic Substitution (SNAr)Principal Investigator
- Principal Investigator
  
  MATSUMOTO Yotaro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Teikyo University
  The University of Tokyo
Chemical control of protein dramatype
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2024 2023 2020 2019 2018 2017 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Development of a LC-MS/MS analytical method of 15 compounds related to renal function for a prognostic method of progression risk in patients with diabetic kidney disease2023
- Author(s)
  Kujirai Ryota、Matsumoto Yotaro、Abe Mizuki、Hiramoto Kodai、Watanabe Takumi、Suzuki Chitose、Toyohara Takafumi、Abe Takaaki、Tomioka Yoshihisa
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis Open
  
  Volume: 2 Pages: 100021-100021
- DOI
  10.1016/j.jpbao.2023.100021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06737
[Journal Article] Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease2023
- Author(s)
  Oshita Toma、Watanabe Shun、Toyohara Takafumi、Kujirai Ryota、Kikuchi Koichi、Suzuki Takehiro、Suzuki Chitose、Matsumoto Yotaro、Wada Jun、Tomioka Yoshihisa、Tanaka Tetsuhiro、Abe Takaaki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 12508-12508
- DOI
  10.1038/s41598-023-39657-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06737, KAKENHI-PROJECT-23K07713, KAKENHI-PROJECT-21K08270
[Journal Article] The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.2018
- Author(s)
  Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.
- Journal Title
  
  Neuroscience.
  
  Volume: 377 Pages: 87-97
- DOI
  10.1016/j.neuroscience.2018.02.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-16J02855, KAKENHI-PROJECT-16K20909, KAKENHI-PROJECT-16H05219
[Journal Article] An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody2017
- Author(s)
  Tsukamoto Hiroki、Yamagata Yuki、Ukai Ippo、Takeuchi Shino、Okubo Misaki、Kobayashi Yohei、Kozakai Sao、Kubota Kanae、Mumasaki Muneo、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tomioka Yoshihisa
- Journal Title
  
  FEBS Letters
  
  Volume: 591 Issue: 16 Pages: 2406-2416
- DOI
  10.1002/1873-3468.12768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20909
[Journal Article] Simultaneous quantitative analysis of uremic toxins by LC-MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column2017
- Author(s)
  Kanemitsu Yoshitomi、Asaji Kei、Matsumoto Yotaro、Tsukamoto Hiroki、Saigusa Daisuke、Mukawa Chikahisa、Tachikawa Tatsuki、Abe Takaaki、Tomioka Yoshihisa
- Journal Title
  
  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
  
  Volume: 1068-1069 Pages: 1-8
- DOI
  10.1016/j.jchromb.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20909
[Journal Article] Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach2017
- Author(s)
  †Mishima, E., †Fukuda, S. (†equally contributed), Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T.
- Journal Title
  
  Kidney International
  
  Volume: 92 Issue: 3 Pages: 634-645
- DOI
  10.1016/j.kint.2017.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04901, KAKENHI-PROJECT-16K19474, KAKENHI-PROJECT-16K20909
[Journal Article] Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry.2017
- Author(s)
  4.Jinno D, Kanemitsu Y, Saitoh K, Nankumo S, Tsukamoto H, Matsumoto Y, Abe T, Tomioka Y
- Journal Title
  
  J Anal Sci Technol.
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1186/s40543-017-0110-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04704, KAKENHI-PROJECT-26460058
[Journal Article] Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan eceptors.2014
- Author(s)
  Hirozumi Toyama　他５名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 6 Pages: 1948-1959
- DOI
  10.1016/j.bmc.2014.01.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24790004
[Journal Article] Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.2014
- Author(s)
  Daisuke Kajita　他４名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 7 Pages: 2244-2252
- DOI
  10.1016/j.bmc.2014.02.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24790004
[Journal Article] Organosilicon Compounds as Adult T-Cell Leukemia Cell Proliferation Inhibitors2013
- Author(s)
  Nakamura, M., Matsumoto, Y., Toyama, M., Baba, M. and Hashimoto, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 61 Issue: 2 Pages: 237-241
- DOI
  10.1248/cpb.c12-00839
- NAID
  130003360727
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790004
[Journal Article] Amidocuprates for Directed ortho Cupration : Structural Study, Mechanistic Investigation, and Chemical Requirements2012
- Author(s)
  Shinsuke Komagawa
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 51 Issue: 48 Pages: 12081-12085
- DOI
  10.1002/anie.201204923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J01857, KAKENHI-PROJECT-24790004
[Journal Article] Specific Inhibitors of Puromycin-Sensitive Aminopeptidase with a 3-(Halogenated Phenyl)-2,4(1H,3H)-quinazolinedione Skeleton2012
- Author(s)
  Matsumoto, Y., Noguchi-Yachide, T., Nakamura, M., Mita, Y., Numadate, A. and Hashimoto, Y.
- Journal Title
  
  Heterocycles
  
  Volume: 86 Issue: 2 Pages: 1449-1463
- DOI
  10.3987/com-12-s(n)109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10146, KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24790004
[Presentation] DKD進行予測マーカー候補化合物精密定量系における分析対象の拡大と新規カラムの分離・保持検討2024
- Author(s)
  今野愛、鯨井涼太、安部水輝、松本洋太郎、阿部高明、富岡佳久
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-23K06737
[Presentation] 糖尿病性腎臓病における腎機能予後予測法の実現を志向したバイオマーカー候補低分子化合物のLC-MS/MS同時定量法の開発研究2024
- Author(s)
  鯨井涼太、安部水輝、平本航大、渡辺匠、鈴木千登世、豊原敬文、阿部高明、松本洋太郎、富岡佳久
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-23K06737
[Presentation] 安定同位体内標準物質を用いた修飾核酸一斉定量系の構築2020
- Author(s)
  平本航大、渡辺匠、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H03509
[Presentation] CKD評価法に用いる蛍光標識フェニルサルフェートの合成2019
- Author(s)
  中村隆太郎、松本洋太郎、塚本宏樹、金光祥臣、富岡佳久
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19H03509
[Presentation] 多層オミクス手法による放射線耐性化関連分子の探索2018
- Author(s)
  富岡佳久、金光祥臣、松本洋太郎、桑原義和、福本　学、塚本宏樹
- Organizer
  第3回治療耐性がん細胞研究協議会セミナー
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] 修飾核酸の高精度一斉定量系の構築2018
- Author(s)
  平本航大、松本洋太郎、塚本宏樹、富岡佳久
- Organizer
  日本薬学会　第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16H04704
[Presentation] ミックスドモード ODS カラムを用いた LC-MS/MS による尿毒症物質一斉定量系の構築2017
- Author(s)
  金光祥臣、淺地圭、松本洋太郎、塚本宏樹、三枝大輔、阿部高明、富岡佳久
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] LC-HDMS および IMS を用いたヒト肝癌組織メタボロミクスによる新規バイオマーカーの同定2017
- Author(s)
  永井滉士、三枝大輔、山崎貴広、金光祥臣、塚本宏樹、池田均、矢冨裕、松本洋太郎、富岡佳久
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16K20909
[Presentation] 新規 ROR 転写抑制リガンドの創製とケイ素導入による活性の向上2014
- Author(s)
  外山　大純，中村　雅陽，中村　政彦，松本　洋太郎，中込　まどか，橋本　祐一
- Organizer
  日本薬学会第134回年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24790004
[Presentation] 膠芽腫幹細胞を標的とした sirtuin2 阻害剤の創製研究2014
- Author(s)
  境　太希，若井　信彦，松本　洋太郎，林　寛敦，石川　稔，杉田　和幸，北尾　彰朗，秋山　徹，橋本　祐一
- Organizer
  日本薬学会第134回年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24790004
[Presentation] 含ケイ素抗エストロゲン様活性物質の創製2014
- Author(s)
  梶田　大資，中村　雅陽，松本　洋太郎，橋本　祐一
- Organizer
  日本薬学会第134回年会（熊本）
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24790004
[Presentation] 膠芽腫幹細胞を標的としたsirtuin2 阻害剤の創製研究2014
- Author(s)
  境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012
- Author(s)
  谷内出友美、杉田和幸、松本洋太郎、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[]

1. Tomioka Yoshihisa (00282062)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. TSUKAMOTO Hiroki (70423605)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. Saigusa Daisuke (90545237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 可野邦行 (50636404)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. ISHIKAWA Minoru (70526839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGITA Kazuyuki (60542090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YACHIDE Tomomi (20401284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MISAWA Takashi (40709820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Kanemitsu Yoshitomi (30752943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. FUKUMOTO Manabu (60156809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KUWAHARA Yoshikazu (00392225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 秋山泰利 (70635557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 青木順 (90452424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NUMASAKI Muneo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NOGUCHI Tomomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 矢吹悌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 福田真嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUMOTO Yotato 松本 洋太郎

MATSUMOTO Yotaro 松本 洋太郎

Research Projects

Research Products

Co-Researchers

投影型MSイメージング法による脂質ラフト含有スフィンゴ脂質の可視化技術開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cancer diagnostic method based on modified nucleoside profilingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of modified nucleoside profiling methods in precision medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Distribution analysis of S1P on tissue sections by high resolution MS imaging

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for molecules that control the CD39-CD73-adenosine cascade and expand into drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of highly sensitive quantitative system of cADPR for comprehensive evaluation of NAD-related metabolitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the modified nucleic acid for novel cancer evaluation marker candidates and its diagnostic application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Theoretical Study of p-Deficient System Aromatic Nucleophlic Substitution (SNAr)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical control of protein dramatype

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of a LC-MS/MS analytical method of 15 compounds related to renal function for a prognostic method of progression risk in patients with diabetic kidney disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.2018

Author(s)

Journal Title

DOI

Data Source

MATSUMOTO Yotato 松本洋太郎

MATSUMOTO Yotaro 松本洋太郎