Kumagai Yoshito 熊谷嘉人

… Alternative Names

KUMAGAI Yosito 熊谷嘉人

熊谷嘉人クマガイヨシト

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Researcher Number	00250100
Other IDs
Affiliation (Current)	2025: 九州大学, 薬学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 九州大学, 薬学研究院, 特任教授 2011 – 2022: 筑波大学, 医学医療系, 教授 2014: 筑波大学, 大学院人間総合科学研究科, 教授 2007 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 教授 2006: 筑波大学, 大学院人間総合科学研究科, 教授 … More 2004 – 2005: 筑波大学, 大学院・人間総合科学研究科, 教授 2004: 筑波大学, 医学部・社会学系, 教授 2003: 筑波大学, 医学部, 教授 2003: 筑波大学, 社会医学系, 教授 1998 – 2002: 筑波大学, 社会医学系, 助教授 2000: Isukuba University, School of Medicine, Associate Professor, 医学部, 助教授 1999: 筑波大学, 医学部, 講師 1998: Univ.of Tsukuba Inst.of Community Med.Associate Professor, 社会医学系 1996 – 1997: 筑波大学, 社会医学系, 講師 1993: 国立環境研究所, 主任研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Environmental pharmacy / Hygiene / Environmental pharmacy / Basic Section 63030:Chemical substance influence on environment-related / Broad Section K / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Hygiene / Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals / Biological pharmacy … More Except Principal Investigator … More 環境影響評価(含放射線生物学) / Environmental pharmacy / Hygiene / Risk sciences of radiation/Chemicals / Circulatory organs internal medicine / Pathological medical chemistry / Public health/Health science / Public health/Health science Less
Keywords	Principal Investigator 親電子物質 / 共有結合 / 一酸化窒素 / キノン系化合物 / 活性イオウ分子 / 酸化ストレス / ディーゼル排出微粒子 / 環境中親電子物質 / 化学修飾 / ヒ素 … More / 循環器疾患 / ディーゼル排出粒子 / タンパク質付加体 / エクスポソーム / レドックスシグナル伝達 / oxidative stress / 慢性中毒 / 介入研究 / 翻訳後修飾 / シグナル伝達 / メチル水銀 / チオールケミストリー / ケミカルバイオロジー / 多環芳香族炭化水素キノン類 / 大気汚染物質 / 親電子性物質 / 大気中ナノ粒子成分 / 血管調節 / 民生品 / カルボン酸 / リジン残基の化学修飾 / 代謝活性化 / エピジェネティクス変化 / 生体内運命 / イオウ付加体 / レドックスシグナル / 毒性発現 / レドックスシグナル変動 / アンチポーター / 環境中親電子物 / レドックスシグナル系 / 複合曝露 / 複合暴露 / 電子伝達系 / レドックスカップル / レドックスシグナンル伝達 / 活性酸素種 / drinking water / intervention study / nitric oxide / chronic arsenosis / arsenic / 環境疫学 / ビタミン剤 / 慢性ヒ素中毒 / 末梢血管障害 / 井戸水 / tracheal contraction / vasorelaxation / covalent attachment / polycyclic aromatic hydrocarbon quinines / diesel exhaust particles / 血管収縮 / 大気中ナノ粒子 / 気管収縮 / EGFRリン酸化 / NO / 血管内皮機能障害 / 9,10-フェナントラキノン / サイクリックGMP / 井地水中砒素 / 井戸水中砒素 / 慢性砒素中毒 / alteration in gene expression / toxicity / nitric oxide synthase / mercury / 発現変動 / 毒性 / 一酸化窒素合成酵素 / 水銀 / 環境応答 / アミノ基 / 3,4-ジヒドロクマリン / 化学物質過敏症 / 解毒 / 毒性防御 / CSE / CBS / 硫化水素 / S-水銀化 / Nrf2/Keap1システム / グルタチオン / Keap1/Nrf2 / 大気中揮発物質 / レドックスセンサー / C-S切断酵素 / 親電子シグナル / 解毒・排泄 / リスク軽減因子 / センサータンパク質 / 環境科学物質 / S-トランスアリール化 / 多環芳香族炭化水素キノン体 / 親電子化合物 / 新電子性物質 / ナフタレン / 大気汚染 / たんぱく質 / 喘息 / 気道収縮 / 環境化学物質 / 活性酸素 / DT-ジアホラーゼ … More Except Principal Investigator HO-1 / Nrf2 / A549 / CD36 / A170 / Fe-NTA / Prx I / 慢性砒素中毒 / 砒素 / 角化症 / 一酸化窒素 / 活性酸素 / NO / China / Extermination / Well water / Arsenic contamination / Oxidative DNA damage / Carcinogenic / Hyperkeratosis / Chronic arsenic poisoning / 中国 / 予防対策 / 根絶 / 井戸水 / 砒素汚染 / 発癌性 / phenanthraquinone / パーオキシレドキシン / Cu,Zn-SOD / キノン / ヒ素 / HSP70 / スルフォラファン / ニトロキシルラジカル / フェナントラキノン / 血管調節 / 循環器疾患 / 機能障害 / 介入研究 / 慢性中毒 / 色素沈着・脱失 / 砒素の地下水汚染 / arginase / super oxide anion / regression / Citrolline-Arginine cycle / Atherosclerosis / Nitric Oxide / 加齢 / 高脂血症 / 活性酸素(O_2) / 誘導型NO合成酵素(iNOS) / 糖尿病 / NADPHオキシダーゼ / アルギナーゼ / 退縮 / シトルリン-アルギニンサイクル / 動脈硬化 / HSF1 / 熱ショックタンパク質 / 細胞応答システム / 親電子シグナル / PTP1B/EGFR / Keap1/Nrf2 / HSP/HSF1 / ストレス応答 / 親電子物質 / 1,4-ナフトキノン / 親電子 / レドックス / シグナル伝達 / 酸化ストレス / 医薬様植物 / アルツハイマー病 / 肝炎 / 癌 / ホーチミン市 / 転写因子Nrf2 / 生理活性成分 / 南方薬 / 医薬用植物 / Heme oxygenase-1 / Garcinia vilersiana / ベトナム / 生活習慣病 / 公衆衛生学 / バングラデシュ / 国際研究者交流 / アレルギー・喘息 / 公衆生学 / 小児発達 / 胎児発達 / 気象学 / 栄養学 / アレルギー / 感染症 / 環境保健 / 出生コホート / 疫学調査 / cGMP / 頚動脈硬化 / 高血圧 Less

代謝活性化を介した民生品のタンパク質付加体形成によるエピジェネティクス変化Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Kyushu University
環境中親電子物質エクスポソーム研究のモデル化Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  University of Tsukuba
Environmental electrophiles exposome and reactive sulfur species as its regulator moleculePrincipal Investigator
- Principal Investigator
  
  Kumagai Yoshito
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section K
- Research Institution
  University of Tsukuba
電子伝達系におけるユビキノンと活性イオウ分子とのレドックスカップルの意義Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
レドックスシグナル伝達の可逆性担保における活性イオウ分子の役割Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur speciesPrincipal Investigator
- Principal Investigator
  
  Kumagai Yoshito
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  University of Tsukuba
Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles
- Principal Investigator
  
  SAWA Tomohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
  Tohoku University
Activation of cellular signal transduction pathways in protective response to an atmospheric electrophile, 1,4-naphthoquinone
- Principal Investigator
  
  YASUHIRO Shinkai
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
親電子修飾の制御に働く新奇求核分子としての硫化水素Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Exploration of a system for cellular response to the electrophilesexhibiting skin sensitization potentialPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Development of an assay to evaluate the reactivity at chemicals contaminated in the atmosphere, South CaliforniaPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
活性酸素シグナル伝達を制御するCーS切断酵素Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
大気中反応物質により非意図的な化学修飾を受けたタンパク質の生体内運命Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
Sensor proteins and cellular protection factors for environmental electrophilesPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  University of Tsukuba
Exploration of bioactive compounds from traditional medicinal plants in Vietnam
- Principal Investigator
  
  KANAHO Yasunori
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Fetal-birth cohort study in Bangladesh : maternal and child nutrition and environment
- Principal Investigator
  
  WAGATSUMA Yukiko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Public health/Health science
- Research Institution
  University of Tsukuba
Naphthalens that covalently bind to macromolecules contaminated in the atmosphere in southern CaliforniaPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
ディーゼル排出微粒子中に存在する未知の親電子性物質の新規探索法の開発Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
大気中ナノ粒子成分と共有結合して気管収縮を引き起こすタンパク質の同定Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
New evaluation system of cell damage caused by environmental chemicals that effect lifestyle diseases
- Principal Investigator
  
  ISHII Tetsuro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  University of Tsukuba
Biological effect of quinoid compounds causing oxidative stress contaminated in ambient particulate matterPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
A intervention study for improvement of decreased nitric oxide levels and oxidative stress in arsenosis patients in ChinaPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Research on the improvement of the chronic arsenic poisoning in China
- Principal Investigator
  
  YAMAUCHI Hiroshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  St.Marianna University School of medicine
内モンゴルの慢性砒素汚染地域での介入研究
- Principal Investigator
  
  下條信弘 (下条信弘)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tsukuba
中国の慢性砒素汚染地域での介入研究:生体内NO産生変動と中毒症状軽減との関係Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
ディーゼル排出微粒子成分であるフェナントラキノンによる血管調節系の破綻Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
慢性砒素中毒によるNO産生に係る因子の変動とそれに起因する血管調節系の撹乱
- Principal Investigator
  
  下條信弘 (下条信弘)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Tsukuba
一酸化窒素が高血圧・動脈硬化・循環器疾患の発症に及ぼす影響に関する疫学研究
- Principal Investigator
  
  嶋本喬
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Public health/Health science
- Research Institution
  University of Tsukuba
環境物質であるキノン系化合物の曝露による生体内NOの産生低下と循環器疾患の誘発Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Tsukuba
Therapy for Advanced Atherosclerosis by Using Vascular Endocrinological System
- Principal Investigator
  
  HAYASHI Toshio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Role of nitric oxide synthase in mercury toxicityPrincipal Investigator
- Principal Investigator
  
  KUMAGAI Yoshito
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  University of Tsukuba
デイ-ゼル排出粒子によって誘発される喘息様症状におけるフラビン酵素の役割Principal Investigator
- Principal Investigator
  
  熊谷嘉人
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute for Environmental Studies

[Book] 酸化ストレスの医学改訂第2版2014
- Author(s)
  熊谷嘉人.
- Total Pages
  456
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25220103
[Book] 毒性の科学2014
- Author(s)
  熊谷嘉人
- Total Pages
  216
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-25220103
[Book] 改定版分子予防環境医学2010
- Author(s)
  熊谷嘉人
- Publisher
  本の泉社.
- Data Source
  KAKENHI-PROJECT-20241015
[Book] 改定版分子予防環境医学2010
- Author(s)
  熊谷嘉人
- Publisher
  本の泉社
- Data Source
  KAKENHI-PUBLICLY-21117504
[Book] 改定版分子予防環境医学2010
- Author(s)
  熊谷嘉人
- Publisher
  本の泉社
- Data Source
  KAKENHI-PROJECT-22406004
[Book] 改定版分子予防環境医学2010
- Author(s)
  熊谷嘉人
- Publisher
  本の泉社
- Data Source
  KAKENHI-PROJECT-21659154
[Book] 改定版分子予防環境医学2010
- Author(s)
  熊谷嘉人
- Publisher
  本の泉社
- Data Source
  KAKENHI-PROJECT-20241015
[Book] 実験医学増刊号.親電子シグナル伝達2009
- Author(s)
  熊谷嘉人
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-21117504
[Book] 活性酸素シグナルと酸化ストレス(実験医学増刊号)2009
- Author(s)
  熊谷嘉人
- Publisher
  羊土社.
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Extracellularly Secreted Cysteine Derived from Cystine Regulates Oxidative and Electrophilic Stress in HepG2 cells2024
- Author(s)
  Hanako Aoki、Yasuhiro Shinkai Y、Masahiro Akiyama 、Satoshi Yamazaki S、Motohiro Nishida、Yoshito Kumagai
- Journal Title
  
  Free Radical Research
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K28237
[Journal Article] Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine2023
- Author(s)
  Kohei Matsuo, Yumi Abiko, Shigeru Yamano, Akira Toriba, Kimihiko Matsusue, Yoshito Kumagai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 338-342
- DOI
  10.1248/bpb.b22-00543
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15657, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K25015, KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-20K12180
[Journal Article] Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine2023
- Author(s)
  Kohei Matsuo, Yumi Abiko, Shigeru Yamano, Kimihiko Matsusue, Yoshito Kumagai
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 334-337
- DOI
  10.1248/bpb.b22-00531
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15657, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-20K12180
[Journal Article] Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs2022
- Author(s)
  Kumagai Yoshito
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 7 Pages: 968-971
- DOI
  10.1248/bpb.b22-00240
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction2022
- Author(s)
  Shinkai Yasuhiro、Onose Yusuke、Akiyama Masahiro、Hirose Reiko、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 36 Issue: 1 Pages: 23-31
- DOI
  10.1021/acs.chemrestox.2c00223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species2022
- Author(s)
  Uchiyama J. , Akiyama M., Hase K., Kumagai Y., Kim Y.G.
- Journal Title
  
  Cell Reports
  
  Volume: 38(10) Issue: 10 Pages: 110479-110479
- DOI
  10.1016/j.celrep.2022.110479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H00509
[Journal Article] Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain2022
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Shinkai Yasuhiro、Kumagai Yoshito、Fujimura Masatake
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 1 Pages: 31-37
- DOI
  10.2131/jts.47.31
- NAID
  130008139752
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-19K16368
[Journal Article] Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor2022
- Author(s)
  Abiko Yumi、Taguchi Keiko、Hisamori Miwa、Hiyoshi-Arai Kyoko、Luong Nho Cong、Toriba Akira、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 35 Issue: 8 Pages: 1425-1432
- DOI
  10.1021/acs.chemrestox.2c00174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12180, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-23K25015
[Journal Article] Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys2472022
- Author(s)
  Abiko Yumi、Yoshida Eiko、Kumagai Yoshito
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 9 Issue: 1 Pages: 1-5
- DOI
  10.2131/fts.9.1
- NAID
  130008141887
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
- Journal Title
  
  Redox Biology
  
  Volume: 57 Pages: 102514-102514
- DOI
  10.1016/j.redox.2022.102514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-22K19395, KAKENHI-PROJECT-22K19397, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21H03065, KAKENHI-PUBLICLY-22H04799, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation2022
- Author(s)
  Abiko Yumi、Toriba Akira、Kumagai Yoshito
- Journal Title
  
  Redox Experimental Medicine
  
  Volume: 2023 Issue: 1
- DOI
  10.1530/rem-22-0021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12180, KAKENHI-PROJECT-18H05293
[Journal Article] A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones2022
- Author(s)
  Luong Nho Cong、Abiko Yumi、Aoki Hanako、Kumagai Yoshito
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 798-802
- DOI
  10.1248/bpb.b22-00080
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan2022
- Author(s)
  Horai Sawako、Abiko Yumi、Unoki Takamitsu、Shinkai Yasuhiro、Akiyama Masahiro、Nakata Katsushi、Kunisue Tatsuya、Kumagai Yoshito
- Journal Title
  
  Chemosphere
  
  Volume: 295 Pages: 133833-133833
- DOI
  10.1016/j.chemosphere.2022.133833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage2022
- Author(s)
  Liu Jun、Kasai Shuya、Tatara Yota、Yamazaki Hiromi、Mimura Junsei、Mizuno Seiya、Sugiyama Fumihiro、Takahashi Satoru、Sato Tsubasa、Ozaki Taku、Tanji Kunikazu、Wakabayashi Koichi、Maeda Hayato、Mizukami Hiroki、Shinkai Yasuhiro、Kumagai Yoshito、Tomita Hirofumi、Itoh Ken
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 6 Pages: 3201-3201
- DOI
  10.3390/ijms23063201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21K08432, KAKENHI-ORGANIZER-21H05258, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain2022
- Author(s)
  Nomura Ryosuke、Takasugi Nobumasa、Hiraoka Hideki、Iijima Yuta、Iwawaki Takao、Kumagai Yoshito、Fujimura Masatake、Uehara Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15412-15412
- DOI
  10.3390/ijms232315412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Potentiation of methylmercury toxicity by combined metal exposure: in vitro and in vivo models of a restricted metal exposome2022
- Author(s)
  Akiyama M., Shinkai Y., Yamakawa H., Kim Y.G., Kumagai Y.
- Journal Title
  
  Chemosphere
  
  Volume: - Pages: 134374-134374
- DOI
  10.1016/j.chemosphere.2022.134374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-18H05293
[Journal Article] Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression2022
- Author(s)
  Nishiyama Kazuhiro、Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Kato Yuri、Shibata Takahiro、Tanaka Hiroshi、Kurose Hitoshi、Azuma Yasu-Taka、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Eaton Philip、Uchida Koji、Nishida Motohiro
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 716 Pages: 716-716
- DOI
  10.1126/scisignal.abj0644
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07085, KAKENHI-PROJECT-20K21496, KAKENHI-PROJECT-20K16008, KAKENHI-PLANNED-21H05263, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H03383, KAKENHI-PROJECT-19J20086, KAKENHI-PROJECT-22K06646, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-22H00356
[Journal Article] The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice2021
- Author(s)
  Abiko Yumi、Katayama Yusuke、Zhao Wenyang、Horai Sawako、Sakurai Kenji、Kumagai Yoshito
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1
- DOI
  10.1038/s41598-021-96579-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells2021
- Author(s)
  Abiko Yumi、Kurosawa Kohki、Yamakawa Hiroto、Kumagai Yoshito
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 4 Pages: 177-185
- DOI
  10.2131/jts.46.177
- NAID
  130008020939
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K12180
[Journal Article] Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts2021
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 150 Pages: 112061-112061
- DOI
  10.1016/j.fct.2021.112061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K12180
[Journal Article] Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome2021
- Author(s)
  Abiko Yumi、Aoki Hanako、Kumagai Yoshito
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 413 Pages: 115392-115392
- DOI
  10.1016/j.taap.2020.115392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation2021
- Author(s)
  Wang Chen、Okita Yukari、Zheng Ling、Shinkai Yasuhiro、Manevich Lev、Chin Jas M.、Kimura Tomokazu、Suzuki Hiroyuki、Kumagai Yoshito、Kato Mitsuyasu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4187-4197
- DOI
  10.1111/cas.15090
- NAID
  120007178942
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07473, KAKENHI-PROJECT-19K07658, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K20597
[Journal Article] Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.2021
- Author(s)
  Hiraoka, H., Nomura, R., Takasugi, N., Akai, R., Iwawaki, T., Kumagai, Y., Fujimura, M., and Uehara, T.
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 95 Issue: 4 Pages: 1241-1250
- DOI
  10.1007/s00204-021-02982-9
- NAID
  120007185542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J11445, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota2021
- Author(s)
  Seki N, Akiyama M, Yamakawa H, Hase K, Kumagai Y, Kim YG
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 2 Pages: 91-97
- DOI
  10.2131/jts.46.91
- NAID
  130007980544
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490
[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021
- Author(s)
 Takahashi, M., Kubota, T., Fujie, T., Shinkai, Y., Kumagai, Y., Nakano, T., Hara, T., Yamamoto, C.* and Kaji, T.*
- Journal Title
 
 BPB Reports
 
 Volume: 4 Issue: 6 Pages: 175-181
- DOI
 10.1248/bpbreports.4.6_175
- NAID
 130008115933
- ISSN
 2434-432X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K19418, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Synthesis of reactive sulfur species in cultured vascular endothelial cells after exposure to TGF-β1: Induction of cystathionine γ-lyase and cystathionine β-synthase expression mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways2021
- Author(s)
  37.Takahashi, M., Fujie, T., Nakano, T., Hara, T., Shinkai, Y., Takasawa, R., Hara, Y., Kumagai, Y., Yamamoto, C.* and Kaji, T.*
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 11762-11762
- DOI
  10.3390/ijms222111762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor2021
- Author(s)
  Nakahara Kengo、Hamada Kyohei、Tsuchida Tomoki、Takasugi Nobumasa、Abiko Yumi、Shien Kazuhiko、Toyooka Shinichi、Kumagai Yoshito、Uehara Takashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100524-100524
- DOI
  10.1016/j.jbc.2021.100524
- NAID
  120007116763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-20K07014
[Journal Article] Cysteine Trisulfide Protects E.?coli from Electrophile-Induced Death through the Generation of Cysteine Hydropersulfide2020
- Author(s)
  Henderson Catherine F.、Bica Iris、Long Faith T.、Irwin Drew D.、Stull Christine H.、Baker Blaine W.、Suarez Vega Valeria、Taugher Zachary M.、Fletes Eliza D.、Bartleson Juliet M.、Humphrey Megan L.、?lvarez Luc?a、Akiyama Masahiro、Kumagai Yoshito、Fukuto Jon M.、Lin Joseph
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 2 Pages: 678-686
- DOI
  10.1021/acs.chemrestox.9b00494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress2020
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 2 Pages: 545-545
- DOI
  10.3390/ijms21020545
- NAID
  120007132700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Kumagai Yoshito
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 7 Issue: 3 Pages: 161-166
- DOI
  10.2131/fts.7.161
- NAID
  130007840859
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] 酸化ストレスを御する新たな鍵分子の発見2020
- Author(s)
  熊谷嘉人
- Journal Title
  
  医学のあゆみ
  
  Volume: 273 Pages: 256-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Environmental pollutants and the immune response2020
- Author(s)
  Suzuki Takafumi、Hidaka Takanori、Kumagai Yoshito、Yamamoto Masayuki
- Journal Title
  
  Nature Immunology
  
  Volume: 21 Issue: 12 Pages: 1486-1495
- DOI
  10.1038/s41590-020-0802-6
- NAID
  40022683384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K17336, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H05649
[Journal Article] Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B2020
- Author(s)
 Luong Nho Cong、Abiko Yumi、Shibata Takahiro、Uchida Koji、Warabi Eiji、Suzuki Midori、Noguchi Takuya、Matsuzawa Atsushi、Kumagai Yoshito
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 45 Issue: 6 Pages: 349-363
- DOI
 10.2131/jts.45.349
- NAID
 130007851869
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-17H06170
[Journal Article] A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract2020
- Author(s)
  Abiko Yumi、Okada Miyuki、Aoki Hanako、Mizokawa Mai、Kumagai Yoshito
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 145 Pages: 111706-111706
- DOI
  10.1016/j.fct.2020.111706
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Control of Protein Function Through Oxidation and Reduction of Persulfidated States2020
- Author(s)
  E Doka, T Ida, M Dagnell, Y Abiko, N C Luong, N Balog, T Takata, B Espinosa, A Nishimura, Q Cheng, Y Funato, H Miki, J M Fukuto, J R Prigge, E E Schmidt, E S J Arner, Y Kumagai, T Akaike, P Nagy
- Journal Title
  
  Sci Adv
  
  Volume: 6 Issue: 1 Pages: 8358-8358
- DOI
  10.1126/sciadv.aax8358
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19396, KAKENHI-PROJECT-19K15803, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-16K14723, KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-18K14853, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-17H04041, KAKENHI-PUBLICLY-20H05508, KAKENHI-PROJECT-17H06170
[Journal Article] Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone is rescued by α-crystallin chaperone2020
- Author(s)
  Shinkai Yasuhiro、Ding Yunjie、Miura Takashi、Kumagai Yoshito
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 1 Pages: 37-43
- DOI
  10.2131/jts.45.37
- NAID
  130007783941
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells2020
- Author(s)
  Tomoya Fujie, Akane Takahashi, Musubu Takahashi, Takato Hara, Asuka Soyama, Kosho Makino, Hideyo Takahashi, Chika Yamamoto, Yoshito Kumagai, Hiroshi Naka and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6053-6053
- DOI
  10.3390/ijms21176053
- NAID
  120007163377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K16454, KAKENHI-PROJECT-18H05293
[Journal Article] Redox Toxicology of Environmental Chemicals Causing Oxidative Stress2020
- Author(s)
  Zheng F., Goncalves FM., Abiko Y., Li H., Kumagai Y., Aschner M.
- Journal Title
  
  Redox Biology
  
  Volume: － Pages: 101475-101475
- DOI
  10.1016/j.redox.2020.101475
- NAID
  120007132623
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-18H05293
[Journal Article] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子を介した制御2020
- Author(s)
  新開泰弘、秋山雅博、熊谷嘉人
- Journal Title
  
  硫酸と工業
  
  Volume: 73
- NAID
  40022236653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Yoshida Eiko、Ding Yunjie、Yamakawa Hiroto、Shinkai Yasuhiro、Ishii Isao、Kumagai Yoshito
- Journal Title
  
  Toxicology Letters
  
  Volume: 330 Pages: 128-133
- DOI
  10.1016/j.toxlet.2020.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] エクスポソーム2020
- Author(s)
  熊谷嘉人
- Journal Title
  
  実験医学増刊号
  
  Volume: 38 Pages: 14-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Redox Signaling and Reactive Sulfur Species to Regulate Electrophilic Stress2020
- Author(s)
  Kanda Hironori、Kumagai Yoshito
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 9 Pages: 1119-1128
- DOI
  10.1248/yakushi.20-00096
- NAID
  130007893808
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Sulfane Sulfur in Toxicology: A Novel Defense System Against Electrophilic Stress2019
- Author(s)
  Shinkai Yasuhiro、Kumagai Yoshito
- Journal Title
  
  Toxicological Sciences
  
  Volume: 170 Issue: 1 Pages: 3-9
- DOI
  10.1093/toxsci/kfz091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.2019
- Author(s)
  Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 32 Issue: 3 Pages: 447-455
- DOI
  10.1021/acs.chemrestox.8b00340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18H05293
[Journal Article] Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na2S2: Evidence for One-Electron Reduction Reaction2019
- Author(s)
  Abiko Yumi、Nakai Yumi、Luong Nho C.、Bianco Christopher L.、Fukuto Jon M.、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 4 Pages: 551-556
- DOI
  10.1021/acs.chemrestox.8b00158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K15489
[Journal Article] Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload2019
- Author(s)
  Nishimura Akiyuki、Shimoda Kakeru、Tanaka Tomohiro、Toyama Takashi、Nishiyama Kazuhiro、Shinkai Yasuhiro、Numaga-Tomita Takuro、Yamazaki Daiju、Kanda Yasunari、Akaike Takaaki、Kumagai Yoshito、Nishida Motohiro
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 587
- DOI
  10.1126/scisignal.aaw1920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07085, KAKENHI-PROJECT-19K16363, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19J20086, KAKENHI-PROJECT-18K14921, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-19H03383
[Journal Article] Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules2019
- Author(s)
  Kumagai Yoshito、Akiyama Masahiro、Unoki Takamitsu
- Journal Title
  
  Toxicological Research
  
  Volume: 35 Issue: 4 Pages: 303-310
- DOI
  10.5487/tr.2019.35.4.303
- NAID
  120007127813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Journal Title
  
  Environmental Health Perspectives
  
  Volume: 127 Issue: 6 Pages: 067002-067002
- DOI
  10.1289/ehp4949
- NAID
  120007133174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-18H05277
[Journal Article] Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells2019
- Author(s)
  Tomoya Fujie, Fukuta Takenaka, Eiko Yoshida, Shuji Yasuike, Yasuyuki Fujiwara, Yasuhiro Shinkai, Yoshito Kumagai, Chika Yamamoto, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 5 Pages: 327-333
- DOI
  10.2131/jts.44.327
- NAID
  130007642916
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-18H05293
[Journal Article] Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology2018
- Author(s)
  Fukuto Jon M.、Ignarro Louis J.、Nagy Peter、Wink David A.、Kevil Christopher G.、Feelisch Martin、Cortese-Krott Miriam M.、Bianco Christopher L.、Kumagai Yoshito、Hobbs Adrian J.、Lin Joseph、Ida Tomoaki、Akaike Takaaki
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 12 Pages: 2140-2152
- DOI
  10.1002/1873-3468.13090
- NAID
  120007133961
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H04020, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-18H05293
[Journal Article] The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems2018
- Author(s)
  Bianco Christopher L、Akaike Takaaki、Ida Tomoaki、Nagy Peter、Bogdandi Virag、Toscano John P、Kumagai Yoshito、Henderson Catherine F、Goddu Robert N、Lin Joseph、Fukuto Jon M
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 176 Issue: 4 Pages: 671-683
- DOI
  10.1111/bph.14372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-18H04020, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PROJECT-18H05293
[Journal Article] Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.2018
- Author(s)
  Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.
- Journal Title
  
  Sci Signal
  
  Volume: 11 Issue: 556 Pages: 5185-5195
- DOI
  10.1126/scisignal.aat5185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K15483, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-18H05293
[Journal Article] Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation2018
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito、Goncalves Filipe Marques、Farina Marcelo、da Rocha Joao Batista Teixeira、Aschner Michael
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 9 Pages: 373-373
- DOI
  10.3389/fgene.2018.00373
- NAID
  120007128084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic2018
- Author(s)
  Abiko Yumi、Kumagai Yoshito
- Journal Title
  
  Arsenic Contamination in Asia
  
  Volume: - Pages: 151-161
- DOI
  10.1007/978-981-13-2565-6_9
- ISBN
  9789811325649, 9789811325656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis2018
- Author(s)
  Kawaguchi Hoshimi、Matsumoto Isao、Osada Atsumu、Kurata Izumi、Ebe Hiroshi、Tanaka Yuki、Inoue Asuka、Umeda Naoto、Kondo Yuya、Tsuboi Hiroto、Shinkai Yasuhiro、Kumagai Yoshito、Ishigami Akihito、Sumida Takayuki
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20 Issue: 1 Pages: 66-66
- DOI
  10.1186/s13075-018-1562-7
- NAID
  120007128092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017
- Author(s)
  Akaike Takaaki、、、Nishida Motohiro（4）、、、、、、Fujii Shigemoto（20）、、、Motohashi Hozumi（26）
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1177-1177
- DOI
  10.1038/s41467-017-01311-y
- NAID
  120007134656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K17583, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26110003, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PLANNED-26116005, KAKENHI-PROJECT-16H05092
[Journal Article] The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity2017
- Author(s)
  Akiyama Masahiro、Shinkai Yasuhiro、Unoki Takamitsu、Shim Ilseob、Ishii Isao、Kumagai Yoshito
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 30 Issue: 12 Pages: 2209-2217
- DOI
  10.1021/acs.chemrestox.7b00278
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-16H05107
[Journal Article] Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides.2017
- Author(s)
  Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y.
- Journal Title
  
  Toxicolgical Sciences
  
  Volume: 156 Pages: 412-421
- DOI
  10.1093/toxsci/kfw268
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042
[Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice2017
- Author(s)
  Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7511-7511
- DOI
  10.1038/s41598-017-07903-4
- NAID
  120007128849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K15585, KAKENHI-PUBLICLY-16H01656, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092
[Journal Article] Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts2017
- Author(s)
  Abiko Yumi、Shinkai Yasuhiro、Unoki Takamitsu、Hirose Reiko、Uehara Takashi、Kumagai Yoshito
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 4814-4814
- DOI
  10.1038/s41598-017-04590-z
- NAID
  120007128910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K08042, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-15H04649
[Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells2017
- Author(s)
  Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 30 Issue: 9 Pages: 1673-1684
- DOI
  10.1021/acs.chemrestox.7b00120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K17583, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-16H05092
[Journal Article] Modulation of Unfolded Protein Response by Methylmercury2017
- Author(s)
  Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 9 Pages: 1595-1598
- DOI
  10.1248/bpb.b17-00359
- NAID
  130006038778
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H04649, KAKENHI-PROJECT-16J00339
[Journal Article] Environmental electrophiles: protein adducts, modulation of redox signaling and interaction with persulfides/polysulfides.2017
- Author(s)
  Kumagai Y, Abiko Y.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 30 Issue: 1 Pages: 203-219
- DOI
  10.1021/acs.chemrestox.6b00326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-17K15489
[Journal Article] 環境中親電子物質のレドックスシグナル伝達変動および毒性発現とそれらを制御する活性イオウ分子2017
- Author(s)
  熊谷嘉人、安孫子ユミ
- Journal Title
  
  硫酸と工業
  
  Volume: 70 Pages: 9-16
- NAID
  40021306408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides2017
- Author(s)
  Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 104 Pages: 118-128
- DOI
  10.1016/j.freeradbiomed.2016.12.047
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18994, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-17K15489, KAKENHI-PROJECT-15K08042
[Journal Article] Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production.2017
- Author(s)
  Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 1 Pages: 205-216
- DOI
  10.1074/jbc.m116.744755
- NAID
  120007135104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26460397, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K08747, KAKENHI-PROJECT-16K15681
[Journal Article] Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity2017
- Author(s)
  Yoshida Eiko、Kurita Masaru、Eto Komyo、Kumagai Yoshito、Kaji Toshiyuki
- Journal Title
  
  Toxicology
  
  Volume: 392 Pages: 40-46
- DOI
  10.1016/j.tox.2017.09.013
- NAID
  120007134588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K21405
[Journal Article] 環境中親電子物質に対する生体応答と捕獲・不活性化因子2017
- Author(s)
  熊谷嘉人
- Journal Title
  
  最新医学「エピジェネティックスと環境科学」
  
  Volume: 72 Pages: 77-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Regulation of redox signaling by nitrated nucleotide and reactive cysteine persulfides. Nitric Oxide: Biology and Pathobiology.2017
- Author(s)
  Sawa T, Kumagai Y, Akaike T.
- Journal Title
  
  Nitric Oxide: Biology and Pathobiology
  
  Volume: 3 Pages: 231-235
- DOI
  10.1016/b978-0-12-804273-1.00017-x
- ISBN
  9780128042731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator2016
- Author(s)
  Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 6 Pages: 775-781
- DOI
  10.2131/jts.41.775
- NAID
  130005281972
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906
[Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016
- Author(s)
  Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 58 Issue: 2 Pages: 91-98
- DOI
  10.3164/jcbn.15-111
- NAID
  130005132519
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-16KT0013
[Journal Article] The chemicall biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generateon.2016
- Author(s)
  Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 97 Pages: 136-147
- DOI
  10.1016/j.freeradbiomed.2016.05.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16K15208, KAKENHI-INTERNATIONAL-15K21759
[Journal Article] Chemical toxicology of reactive species in the atmosphere: two decades of progress in an electron acceptor and an electrophile.2016
- Author(s)
  Kumagai Y, Abiko Y, Luong CN.
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 41 Issue: Special Pages: SP37-SP47
- DOI
  10.2131/jts.41.sp37
- NAID
  130005251461
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15K18906
[Journal Article] Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells.2016
- Author(s)
  Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 295 Pages: 37-46
- DOI
  10.1016/j.taap.2016.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-15K14992, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034, KAKENHI-PUBLICLY-16H01190, KAKENHI-PROJECT-15KK0325
[Journal Article] Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells2016
- Author(s)
  Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 28944-28944
- DOI
  10.1038/srep28944
- NAID
  120007135346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092, KAKENHI-PROJECT-16H05387, KAKENHI-PROJECT-15K14952, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K15573, KAKENHI-PROJECT-16K18920, KAKENHI-PROJECT-15H04649
[Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015
- Author(s)
  Saund SS, Sosa V, Henriquez, Nguyen QNN, Soeda S, Bianco CL, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.
- Journal Title
  
  Archives Biochemistry and Biophysics.
  
  Volume: 588 Pages: 15-24
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Journal Article] Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells2015
- Author(s)
  Abiko Y, Puga A, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 6 Pages: 873-886
- DOI
  10.2131/jts.40.873
- NAID
  130005108871
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-25220103
[Journal Article] S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells2015
- Author(s)
 Toyama T, Abiko Y, Katayama Y, Kaji T, Kumagai Y.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 40 Issue: 6 Pages: 887-893
- DOI
 10.2131/jts.40.887
- NAID
 130005108872
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-25220103
[Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015
- Author(s)
  Saund SS, Sosa V, Henriquez, Nguyen QNN, Soeda S, Bianco CL, Millikin R, White C, Le H, Ono K, Tantillo DJ, Kumagai Y, Akaike T, Lin J, Fukuto JM.
- Journal Title
  
  Archives Biochemistry and Biophysics.
  
  Volume: 588 Pages: 15-24
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Correlation Between Attenuation of Protein Disulfide Isomerase Activity Through S-Mercuration and Neurotoxicity Induced by Methylmercury.2015
- Author(s)
  Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
- Journal Title
  
  Neurotox Res
  
  Volume: 27 Issue: 2 Pages: 99-105
- DOI
  10.1007/s12640-014-9494-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670029, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26460068
[Journal Article] Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells.2015
- Author(s)
  Fujiwara Y, Yamamoto C, Yoshida A, Kumagai Y, Kaji T.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 印刷中 Issue: 2 Pages: 259-267
- DOI
  10.1007/s00204-014-1420-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-24390034
[Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.2015
- Author(s)
  Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
- Journal Title
  
  J Mol Med (Berl).
  
  Volume: 印刷中 Issue: 8 Pages: 879-889
- DOI
  10.1007/s00109-015-1271-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25870549, KAKENHI-PROJECT-26460960, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020
[Journal Article] Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice.2015
- Author(s)
  Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H, Akahoshi N, Kasahara T, Kumagai Y, Ishii I.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 282 Issue: 2 Pages: 195-206
- DOI
  10.1016/j.taap.2014.11.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072
[Journal Article] Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice2015
- Author(s)
  Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 6 Pages: 837-841
- DOI
  10.2131/jts.40.837
- NAID
  130005108870
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-25460072
[Journal Article] A Biotin-PEAC5-maleimide labeling assay to detect electrophiles.2015
- Author(s)
  Abiko Y, Luong NC, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 3 Pages: 405-411
- DOI
  10.2131/jts.40.405
- NAID
  130005068421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18906, KAKENHI-PROJECT-25220103
[Journal Article] Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides.2015
- Author(s)
  Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 28 Issue: 9 Pages: 1796-1802
- DOI
  10.1021/acs.chemrestox.5b00245
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18994, KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15J03367, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020
[Journal Article] RSSによる環境中親電子物質の解毒代謝.2015
- Author(s)
  熊谷嘉人、内田浩二.
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 358-363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015
- Author(s)
  Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 印刷中 Issue: 5 Pages: 838-847
- DOI
  10.1021/tx500416y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25870549, KAKENHI-PROJECT-15K14959, KAKENHI-PROJECT-15K20876, KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670207, KAKENHI-PROJECT-25293018, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25253020
[Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation.2015
- Author(s)
  Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
- Journal Title
  
  Chemical Research in Toxicology.
  
  Volume: 28 Issue: 6 Pages: 1301-1306
- DOI
  10.1021/acs.chemrestox.5b00101
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01392, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-26670207, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25253020
[Journal Article] レドックスサイクルを介して酸化ストレスを生じる大気中成分.2015
- Author(s)
  熊谷嘉人、安孫子ユミ.
- Journal Title
  
  「医学のあゆみ」レドックスUPDATE
  
  Volume: 別冊 Pages: 312-317
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Journal Article] The redox chemistry and chemical biology of H2S, hydropersulfides and derivaed species: implications to their possible biological activity and utility.2014
- Author(s)
  Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 77 Pages: 82-94
- DOI
  10.1016/j.freeradbiomed.2014.09.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670207
[Journal Article] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. Journal of agricultural and food chemistry.2014
- Author(s)
  Abiko Y, Mizokawa M, Kumagai Y.
- Journal Title
  
  J Agric Food Chem.
  
  Volume: 62 Issue: 45 Pages: 10936-10944
- DOI
  10.1021/jf5030592
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014
- Author(s)
  Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: (印刷中) Issue: 21 Pages: 7606-7611
- DOI
  10.1073/pnas.1321232111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24590527, KAKENHI-PROJECT-24790263, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-25870549, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26670207
[Journal Article] Ambient Vapor Samples Activate the Nrf2-ARE Pathway in Human Bronchial Epithelial BEAS-2B Cells2014
- Author(s)
  Yasuhiro Shinkai, Syun Nakajima, Arantza Eiguren-Fernandez, Emma Di Stefano, Debra A. Schmitz, John R. Froines, Arthur K. Cho, Yoshito Kumagai
- Journal Title
  
  Environmental Toxicology
  
  Volume: 29 Pages: 1292-1300
- DOI
  10.1002/tox.21860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590159, KAKENHI-PROJECT-25220103
[Journal Article] Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.2014
- Author(s)
  Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S.
- Journal Title
  
  J Neurochem.
  
  Volume: 130 Issue: 6 Pages: 826-838
- DOI
  10.1111/jnc.12762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-25220103
[Journal Article] Identification and quantification of in vivo metabolites of 9,10-phenanthrenequino ne in human urine associated with producing reactive oxygen species2014
- Author(s)
  Asahi M, Kawai M, Toyama T, Kumagai Y, Chuesaard T, Tang N, Kameda T. Havakawa K and Toriba A
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 27(1) Issue: 1 Pages: 76-85
- DOI
  10.1021/tx400338t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24406001, KAKENHI-PROJECT-24590160, KAKENHI-PROJECT-25220103
[Journal Article] Glutathione adduct of methylmercury activates the Keap1-Nrf2 pathway in SH-SY5Y cells.2014
- Author(s)
  Yoshida E, Abiko Y, Kumagai Y.
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 27 Issue: 10 Pages: 1780-1786
- DOI
  10.1021/tx5002332
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] S-Mercuration of cellular proteins by methylmercury and its toxicological implications2014
- Author(s)
 Kanda H, Shinkai Y, Kumagai Y.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 39 Issue: 5 Pages: 687-700
- DOI
 10.2131/jts.39.687
- NAID
 130004690955
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-25220103
[Journal Article] Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species2014
- Author(s)
  西田基宏、外山喬士、熊谷嘉人、富田拓郎.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 134 Issue: 12 Pages: 1239-1243
- DOI
  10.1248/yakushi.14-00209-1
- NAID
  130004712987
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2014-12-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] たくさん繋がるS.2014
- Author(s)
  澤智裕、熊谷嘉人、赤池孝章.
- Journal Title
  
  実験医学増刊「驚愕の代謝システム」
  
  Volume: 32 Pages: 46-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] The role of the Keap1/Nrf2 pathway in the cellular response to methylmercury2013
- Author(s)
  Kumagai Y, Kanda H, Shinkai Y and Toyama T
- Journal Title
  
  Oxid Med Cell Loneev
  
  Volume: (Online) Pages: 848279-848279
- DOI
  10.1155/2013/848279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-25220103
[Journal Article] A convenient method to assess chemical modification of protein thiols by electrophilic metals2013
- Author(s)
  Toyama T, Shinkai Y, Kaji T and Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 3 Pages: 477-484
- DOI
  10.2131/jts.38.477
- NAID
  10031158913
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-25220103
[Journal Article] Interaction of Keap 1 modified by 2-tert-butyl-1,4-benzoquinone with GSH : Evidence for Stransarylation2013
- Author(s)
  Yumi Abiko, Yoshito Kumagai
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 26 Issue: 7 Pages: 1080-1087
- DOI
  10.1021/tx400085h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J01747, KAKENHI-PROJECT-25220103
[Journal Article] Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.2013
- Author(s)
  Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 436 Issue: 2 Pages: 212-6
- DOI
  10.1016/j.bbrc.2013.05.075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-24390100, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670167
[Journal Article] Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling2013
- Author(s)
  Koizumi R, Taguchi K, Hisamori M, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 3 Pages: 317-324
- DOI
  10.2131/jts.38.317
- NAID
  10031158897
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-25220103
[Journal Article] 酸化ストレスと親電子シグナル制御.2013
- Author(s)
  熊谷嘉人
- Journal Title
  
  医学のあゆみ
  
  Volume: 247 Pages: 787-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells2013
- Author(s)
 Yasuhiro Shinkai, Ichiro Yamanaka, Ho Huynh Thuy Duong, Nguyen Thi Quynh, Yasunori Kanaho, Yoshito Kumagai
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 38 Issue: 6 Pages: 875-878
- DOI
 10.2131/jts.38.875
- NAID
 130004447090
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-24590159, KAKENHI-PROJECT-25220103
[Journal Article] Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells2013
- Author(s)
  Chang B, Iwamoto N, Inaba T, Shinkai Y, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 5 Pages: 793-797
- DOI
  10.2131/jts.38.793
- NAID
  10031191738
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25220103
[Journal Article] Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling.2012
- Author(s)
  Shinkai Y
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 25 Issue: 6 Pages: 1222-1230
- DOI
  10.1021/tx300069r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659063
[Journal Article] A method for detecting covalent modification of sensor proteins associated with 1,4-naphthoquinone-induced activation of electrophilic signal transduction pathways2012
- Author(s)
  Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 37 Issue: 5 Pages: 891-898
- DOI
  10.2131/jts.37.891
- NAID
  130004447003
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-24590159
[Journal Article] The chemical biology of naphthoquinones and its environmental implications2012
- Author(s)
  Kumagai Y
- Journal Title
  
  Annual Review of Pharmacology and Toxicology
  
  Volume: 52 Issue: 1 Pages: 221-247
- DOI
  10.1146/annurev-pharmtox-010611-134517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015, KAKENHI-PROJECT-22406004, KAKENHI-PUBLICLY-23117703, KAKENHI-PROJECT-23659063
[Journal Article] Cho AK. The chemical biology of naphthoquinones and its environmentalimpl ications2012
- Author(s)
  Kumagai Y, Shinkai Y, Miura T
- Journal Title
  
  Annual Review of Pharmacology and Toxicology
  
  Volume: 52 Pages: 221-247
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] 環境中親電子リガンドの細胞内侵入とそれに伴うシグナル伝達の模倣および攪乱.2012
- Author(s)
  熊谷嘉人
- Journal Title
  
  実験医学「活性酸素・ガス状分子による恒常性制御と疾患」
  
  Volume: 30 Pages: 70-75
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117703
[Journal Article] Two-electron quinone reductase (AKR1C isozyme) augments the oxidative DNA damage induced by quinones in diesel exhaust particles by accelerating redox cycling2011
- Author(s)
  Yamano S, Shibata M, Kita H, Matsusue K, Narimatsu S, Taguchi K, Kumagai Y
- Journal Title
  
  Journal of Health Science
  
  Volume: 57 Pages: 107-114
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1, 2-naphthoquinone protein adduct formation2011
- Author(s)
  Miura T, Shinkai Y, Hirose R, Iwamoto N, Cho AK, Kumagai Y
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 51 Pages: 2082-2089
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.2011
- Author(s)
  Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y.
- Journal Title
  
  Envornmental Health Perspective in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] DNA microarray analysis of human neuroblastoma SH-SY5Y cells exposed to methylmercury2011
- Author(s)
  Toyama T, Yoshida E, Shinkai Y, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 36 Pages: 843-845
- NAID
  10030037141
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury2011
- Author(s)
  Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y
- Journal Title
  
  Environmental Health Perspective
  
  Volume: 119 Pages: 1117-1122
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate2011
- Author(s)
  Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 24 Pages: 1836-1844
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Initial response and cellular protection through the Keapl/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone.2011
- Author(s)
  Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y.
- Journal Title
  
  Chemical Research in Toxicology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells2011
- Author(s)
  Takayama N
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 6 Pages: 817-821
- DOI
  10.2131/jts.36.817
- NAID
  10030037072
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015, KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-22790128
[Journal Article] Participation of covalent modification f Keap1 in the activation of Nrf2 by tert-ylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole2011
- Author(s)
  Abiko Y, Miura T, Bui H Phuc, Shinkai Y, Kumagai Y
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 255 Pages: 32-39
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Peroxiredoxin 6 is a molecular target for 1, 2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells2011
- Author(s)
  Takayama N, Iwamoto N, Sumi D, Shinkai Y, Tanaka-Kagawa T, Jinno H, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 36 Pages: 817-821
- NAID
  10030037072
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1, 2-naphthoquinone2011
- Author(s)
  Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 24 Pages: 559-567
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone2011
- Author(s)
  Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 24 Issue: 4 Pages: 559-567
- DOI
  10.1021/tx100427p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-22790127, KAKENHI-PUBLICLY-23117503
[Journal Article] Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole2011
- Author(s)
  Endo A, Sumi D, Iwamoto N, Kumagai Y
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 255 Pages: 32-39
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro2010
- Author(s)
  Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 1 Pages: 761-767
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Biochemical and cellular effects of electrophiles present in ambient air samples2010
- Author(s)
  Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M
- Journal Title
  
  Atmospheric Environment
  
  Volume: 44 Issue: 12 Pages: 1483-1489
- DOI
  10.1016/j.atmosenv.2010.01.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004
[Journal Article] 1, 2-Naphthoquinone suppresses lipopolysaccharidedependentactivation of IKKss/NF-kB/NO signaling : an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation2010
- Author(s)
  Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 35 Pages: 891-898
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic the micals contaminated in the atmosphere2010
- Author(s)
  Kumagai Y
- Journal Title
  
  Journal of Health Sciences 55
  
  Pages: 887-894
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21117504
[Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2010
- Author(s)
  Kumagai Y
- Journal Title
  
  Journal of Health Sciences 55
  
  Pages: 887-894
- NAID
  130000127984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659154
[Journal Article] Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro2010
- Author(s)
  Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H.
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 1 Issue: 5 Pages: 761-767
- DOI
  10.3892/etm.2010.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004
[Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells.2010
- Author(s)
  Abiko Y, Shinkai Y, Sumi D, Kumagai Y.
- Journal Title
  
  Journal of Toxicological Sciences 35
  
  Pages: 419-423
- NAID
  10026469935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Redox and electrophilic properties ofvapor- and particle-phase components of ambient aerosols2010
- Author(s)
  Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, Distefano E, Hinds W, Kumagai Y, Cho AK, Froines JR
- Journal Title
  
  Environmental Research
  
  Volume: 110 Issue: 3 Pages: 207-212
- DOI
  10.1016/j.envres.2010.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004
[Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ)2010
- Author(s)
  Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK.
- Journal Title
  
  Archives of Toxicology
  
  Volume: 84 Issue: 2 Pages: 109-117
- DOI
  10.1007/s00204-009-0427-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406004
[Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants : diesel exhaust particles (DEP) and 1, 2-naphthoquinone (1, 2-NQ)2010
- Author(s)
  Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK
- Journal Title
  
  Archives of Toxicology
  
  Volume: 84 Pages: 109-117
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells2010
- Author(s)
  Abiko Y, Shinkai Y, Sumi D, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 35 Pages: 419-423
- NAID
  10026469935
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells2010
- Author(s)
  Sumi D, Shinkai Y, Kumagai Y
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 244 Pages: 385-392
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Immunochemical method to detect proteins that undergo selective modification by 1, 2-naphthoquinone derived from naphthalene through metabolic activation2010
- Author(s)
  Miura T, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 35 Pages: 843-852
- NAID
  10026963043
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells2010
- Author(s)
  Toyama T, Shinkai Y, Sumi D, Kumagai Y
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 249 Pages: 86-90
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range chemical compounds2009
- Author(s)
  Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 29 Pages: 493-502
- NAID
  120007138388
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2009
- Author(s)
  Kumagai Y
- Journal Title
  
  Journal of Health Sciences 55
  
  Pages: 887-894
- NAID
  130000127984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere2009
- Author(s)
  Kumagai Y
- Journal Title
  
  Journal of Health Sciences
  
  Volume: 55 Pages: 887-894
- NAID
  130000127984
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] 親電子シグナル伝達2009
- Author(s)
  熊谷嘉人
- Journal Title
  
  実験医学増刊号
  
  Volume: 27 Pages: 50-55
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article]2009
- Author(s)
  熊谷嘉人
- Journal Title
  
  実験医学増刊号.親電子シグナル伝達(羊土社)
  
  Pages: 50-55
- Data Source
  KAKENHI-PROJECT-21659154
[Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes2009
- Author(s)
  Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 237 Pages: 232-236
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap12009
- Author(s)
  Sumi D, Numasawa Y, Endo A, Iwamoto N, Kumagai Y
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 34 Pages: 627-635
- NAID
  110007485673
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article]2009
- Author(s)
  熊谷嘉人
- Journal Title
  
  実験医学増刊号.親電子シグナル伝達(羊土社)
  
  Pages: 50-55
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells2008
- Author(s)
  Taguchi K, Shimada M, Fujii S,umi D, Pan XQ,Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Free Radical Biology & Medicine 2008 44
  
  Pages: 1945-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism.2008
- Author(s)
  Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y.
- Journal Title
  
  Archives of Toxicology. 82
  
  Pages: 803-808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Xylulose reductase is involved in 9, 10-phenanthrenequinone-induced apoptosis in human T lymphoma cells2008
- Author(s)
  Matsunaga T, Kamiya T, Sumi D, Kumagai Y, B. Kalyanaraman, Hara A
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 44 Pages: 1191-1202
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Downregulation of Arginase II and Renal Apoptosis by Inorganic Mercury : Overexpression of Arginase II Reduces Its Apoptosis2008
- Author(s)
  Kanda H, Kikushima M, Homma-Takeda S, Sumi D, Endo A, Toyama T, Miura N, Naganuma A, Kumagai Y
- Journal Title
  
  Archives of Toxicology
  
  Volume: 82 Pages: 67-73
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Redox cycling of 9, 10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells2008
- Author(s)
  Taguchi K, Shimada M, Fujii S, Sumi D, 24. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Free Radical Biology & Medicine
  
  Volume: 44 Pages: 1645-1655
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles2008
- Author(s)
  Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK
- Journal Title
  
  Evidence for electrophilic species 42
  
  Pages: 517-529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism2008
- Author(s)
  Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y
- Journal Title
  
  Archives of Toxicology
  
  Volume: 82 Pages: 803-808
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells.2008
- Author(s)
  Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y.
- Journal Title
  
  Free Radical Biology & Medicine 44
  
  Pages: 1645-1655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241015
[Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice2007
- Author(s)
  Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y
- Journal Title
  
  Archives of Toxicology 2007 81
  
  Pages: 575-581
- NAID
  120007139196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Arsenic: Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity2007
- Author(s)
  Kumagai Y
- Journal Title
  
  Annual Review of Pharmacology and Toxicology 47
  
  Pages: 243-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18256005
[Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice.2007
- Author(s)
  Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y.
- Journal Title
  
  Eur Respir J. 29
  
  Pages: 259-267
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice2007
- Author(s)
  Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y
- Journal Title
  
  European Respiratory Journal 2007 29
  
  Pages: 259-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress2007
- Author(s)
  Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y
- Journal Title
  
  Free Radical Biology & Medicine 2007 43
  
  Pages: 789-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Arsenic : signal transduction, Transcription factor, and biotransformation involved in cellular response and toxicity2007
- Author(s)
  Kumagai, Y
- Journal Title
  
  Annual Review of Pharmacology and Toxicology 47
  
  Pages: 243-262
- Data Source
  KAKENHI-PROJECT-18256005
[Journal Article] Chemical knockdown of protein tyrosine phosphatase 1B by 1, 2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor2007
- Author(s)
  Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Journal of Biological Chemistry 2007 282
  
  Pages: 33396-33404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Naphthoquinone enhances antigen-related airway inflammation in mice.2007
- Author(s)
  Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y.
- Journal Title
  
  Eur Respir J. 29
  
  Pages: 259-267
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] Arsenic : Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity.2007
- Author(s)
  Kumagai Y, Sumi D.
- Journal Title
  
  Annu Rev Pharmacol Toxicol. 47
  
  Pages: 243-262
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity2007
- Author(s)
  Kumagai Y, Sumi D. Arsenic
- Journal Title
  
  Annual Review of Pharmacology and Toxicology 47
  
  Pages: 243-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18256005
[Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice.2007
- Author(s)
  Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y.
- Journal Title
  
  Arch Toxicol. (In press)
- NAID
  120007139196
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice.2007
- Author(s)
  Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y.
- Journal Title
  
  Arch Toxicol. (In press)
- NAID
  120007139196
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Arsenic : Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity.2007
- Author(s)
  Kumagai Y, Sumi D.
- Journal Title
  
  Annu Rev Pharmacol Toxicol. 47
  
  Pages: 243-262
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity2007
- Author(s)
  Y. Kumagai, et. al.
- Journal Title
  
  Annu. Rev. Pharm. 47
  
  Pages: 789-799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406003
[Journal Article] 1, 2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
- Author(s)
  Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y.
- Journal Title
  
  Toxicology and Applied Pharmacology. 210
  
  Pages: 47-54
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
- Author(s)
  Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Toxicology, and Applied Pharmacology 210
  
  Pages: 47-54
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression of Endothelium-Dependent Vasorelaxation by 1,2-Naphthoquinone, a Component of Diesel Exhaust Particles.2006
- Author(s)
  Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y.
- Journal Title
  
  Arch Toxicol. 80
  
  Pages: 280-285
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
- Author(s)
  Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y.
- Journal Title
  
  Toxicology and Applied Pharmacology. 210
  
  Pages: 47-54
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.2006
- Author(s)
  Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines, JR, Kumagai Y
- Journal Title
  
  Toxicology, and Applied Pharmacology 210
  
  Pages: 47-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Sulforphane, an activator of Nrf2,suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
- Author(s)
  Shinkai Y, sumi D, Fukami I, Ishii T, Kumagai Y
- Journal Title
  
  FEBS Letters (In press)
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
- Author(s)
  Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y.
- Journal Title
  
  FEBS Letters. 580
  
  Pages: 1771-1774
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression of Endothelium-Dependent Vasorelaxation by 1, 2-Naphthoquinone, a Component of Diesel Exhaust Particles.2006
- Author(s)
  Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y.
- Journal Title
  
  Arch Toxicol. 80
  
  Pages: 280-285
- Data Source
  KAKENHI-PROJECT-18659167
[Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
- Author(s)
  Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y.
- Journal Title
  
  FEBS Letters. 580
  
  Pages: 1771-1774
- Data Source
  KAKENHI-PROJECT-18406003
[Journal Article] Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.2006
- Author(s)
  Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y
- Journal Title
  
  FEBS Letters (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Effects of single intratracheal administration of phenanthraquinone on murine lung.2005
- Author(s)
  Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Journal of Applied Toxicology 25
  
  Pages: 47-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu, Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis.2005
- Author(s)
  Sugimoto R, Kumagai Y, Nakai Y, Ishii T
- Journal Title
  
  Free Radical Biology & Medicine 38
  
  Pages: 388-397
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Effects of phenanthraquinone on allergic airway inflammation in mice.2005
- Author(s)
  Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Kumagai Y
- Journal Title
  
  Clinical Experimental Allergy 35
  
  Pages: 1243-1248
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Effects of single intraracheal administration of phenanthraquinoes on murine lung.2005
- Author(s)
  Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y
- Journal Title
  
  Journal of Applied Toxicology 25
  
  Pages: 47-51
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure.2005
- Author(s)
  Pi JB, Yamauchi H, Sun GF, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui RZ, Kumagai Y
- Journal Title
  
  Environmental Health Perspective 113
  
  Pages: 339-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Effects of single intratracheal administration of phenanthraquinone on murine lung.2005
- Author(s)
  Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines, JR, Kumagai Y
- Journal Title
  
  Journal of Applied Toxicology 25
  
  Pages: 47-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu, Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1.10-phenanthroline affords protection against apoptosis.2005
- Author(s)
  Sugimoto R, Kumagai Y, Nakai Y, Ishii T
- Journal Title
  
  Free Radical Biology & Medicine 38
  
  Pages: 388-397
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] 9,10-phenanthraquinone in diesel exhaust downregulates HO-1 and Cu,Zn-SOD in human pulmonary epithelial cells : intracellular iron scavenger 1.10-phenanthroline affords protection against apoptosis.2005
- Author(s)
  Sugimoto R, Kumagai Y, Nakai Y, Ishii T
- Journal Title
  
  Free Radical Biology & Medicine 38
  
  Pages: 388-397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Monomethylarsonous acid inhibits endothelial nitric oxide activity.2005
- Author(s)
  Sumi D, Taguchi K, Sun Y, Shinkai Y, Kumagai Y
- Journal Title
  
  Journal of Health Sciences 52
  
  Pages: 728-730
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Redox activity of airborne particulate matter at different sites in the Los Angeles Basin.2005
- Author(s)
  Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR
- Journal Title
  
  Environmental Research 99
  
  Pages: 40-47
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Redox activity of airborne particulate matter at different sites in the Los Angels Basin.2005
- Author(s)
  Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR
- Journal Title
  
  Environmental Research 99
  
  Pages: 40-47
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Monomethylarsonous acid inhibits endothelial nitritic oxide activity.2005
- Author(s)
  Sumi D, Taguchi K, Sun Y, Shinkai Y, Kumagai Y
- Journal Title
  
  Journal of Health Sciences 52
  
  Pages: 728-730
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
- Author(s)
  Kumagai Y et al.
- Journal Title
  
  Free Rad Biol Med 37
  
  Pages: 350-357
- Data Source
  KAKENHI-PROJECT-15659141
[Journal Article] Determination of four quinones in diesel exhaust particles, SRM1649a and, atmospheric PM2.5.2004
- Author(s)
  Cho AK, Schmitz DA, Ying Y, Rodriguez CE, DiStefano EW, Kumagai Y, Miguel A, Eiguren A, Kobayashi T, Avol E, Froines JR
- Journal Title
  
  Aerosol Science and Technology 38
  
  Pages: 68-81
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
- Author(s)
  Kumagai Y et al.
- Journal Title
  
  Free Rad Biol Med 37
  
  Pages: 350-357
- Data Source
  KAKENHI-PROJECT-15390184
[Journal Article] Neuronal nitric oxide synthase (nNOS) catalyzes one-electron reduction of 2,4,6-trinitrotoluene, resulting in decreased nitric oxide production and increased nNOS gene expression : Implication for oxidative stress.2004
- Author(s)
  Kumagai Y et al.
- Journal Title
  
  Free Rad Biol Med 37
  
  Pages: 350-357
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Molecular basis for arsenic-mediated alteration in nitric oxide production and oxidative stress : implication of endothelial dysfunction.2004
- Author(s)
  Kumagai Y, Pi JB.
- Journal Title
  
  Toxicol Appl Pharmacol 198
  
  Pages: 450-457
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Decreased enzyme activities of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenate.2003
- Author(s)
  Nikaido M, Pi JB, Kumagai Y, Yamauchi H, Taguchi K, Horiguchi S, Sun Y, Sun GF, Shimojo N
- Journal Title
  
  Environmental Toxicology 18
  
  Pages: 306-311
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits.2003
- Author(s)
  Pi JB, Horiguchi S, Sun Y, Nikaido M, Shimojo N, Hayashi T, Yamauchi H, Sun GF, Itoh K, Yamamoto M, Waalkes MP, Kumagai Y
- Journal Title
  
  Free Radical Biology & Medicine 35
  
  Pages: 102-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] Molecular Basis for Arsenic-Mediated Alteration in Nitric Oxide Puroduction and Oxidative Stress : Implication of Endothelial Dysfunction2003
- Author(s)
  Kumagai Y, Pi JB.
- Journal Title
  
  Toxicology and Applied Pharmacology (in press)
- Data Source
  KAKENHI-PROJECT-13576029
[Journal Article] Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes : involvement of hydrogen peroxide.2003
- Author(s)
  Pi JB, Qu W, Reece J M, Kumagai Y
- Journal Title
  
  Experimental Cell Research 290
  
  Pages: 234-245
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15406004
[Journal Article] ディーゼル排出微粒子と酸化ストレス防御蛋白質2002
- Author(s)
  石井哲郎, 熊谷嘉人
- Journal Title
  
  The Lung Perspective 10
  
  Pages: 64-69
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to exvironmental chemicals2002
- Author(s)
  Kumagai Y, Shimojo N.
- Journal Title
  
  Environmental Health and Preventive Mdicine 7
  
  Pages: 141-150
- Data Source
  KAKENHI-PROJECT-13575036
[Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to exvironmental chemicals2002
- Author(s)
  Kumagai Y, Shimojo N.
- Journal Title
  
  Environmental Health and Preventive Mdicine 7
  
  Pages: 141-150
- Data Source
  KAKENHI-PROJECT-13680620
[Journal Article] Oxidatrion of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust uarticles2002
- Author(s)
  Kumagai Y, Koide S, Taguchi K, et al.
- Journal Title
  
  Chemical Research in Toxicology 15
  
  Pages: 483-489
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] Posaible Mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to environmental chemicals2002
- Author(s)
  Kumagai Y, Shimojo N.
- Journal Title
  
  Environmental Health and Preventive Medicine 7
  
  Pages: 141-150
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] Possible mechanisms for induction of oxidative stress and suppression of systemic nitric oxide production caused by exposure to environmental chemicals2002
- Author(s)
  Kumagai Y, Shimojo N.
- Journal Title
  
  Environmental Health and Perventive Medicine 7
  
  Pages: 141-150
- NAID
  110004087642
- Data Source
  KAKENHI-PROJECT-13576029
[Journal Article] Evidence for induction of oxidative stress caused by chronic eaposure of Chinese residents to arsenic contained in drinking water2002
- Author(s)
  Pi JB, Yamauchi H, Kumagai Y, et al.
- Journal Title
  
  Environmental Health Perspective 110
  
  Pages: 331-336
- Data Source
  KAKENHI-PROJECT-13575036
[Journal Article] Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water2002
- Author(s)
  Pi JB, Yamauchi H, Kumagai Y, et al.
- Journal Title
  
  Environmental Health Perspective 110
  
  Pages: 331-336
- Data Source
  KAKENHI-PROJECT-13576029
[Journal Article] Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water2002
- Author(s)
  Pi JB, Yamauchi H, Kumagai Y, et al.
- Journal Title
  
  Environmental Health Perspective 110
  
  Pages: 331-336
- Data Source
  KAKENHI-PROJECT-13680620
[Journal Article] Phenanthraquinone affects endothelial nitric oxide synthase activity through modification of the thiol groups : An alternative inhibition machanism2001
- Author(s)
  Taguchi K, Kumagai Y, Endo A, ei al.
- Journal Title
  
  Journal of Health Sciences 47
  
  Pages: 571-574
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation2001
- Author(s)
  Kumagai Y, Hayashi T, Miyauchi T, et al.
- Journal Title
  
  American Journal of Physiology 281
- Data Source
  KAKENHI-PROJECT-13672340
[Journal Article] Induction of oxidative stress and dyafunction of nitric oxide-dependent vascular tone caused by quinones contained in diesel exhaust particles2001
- Author(s)
  Kumagai Y, Shimojo N.
- Journal Title
  
  Journal of Health Sciences 47
  
  Pages: 439-445
- Data Source
  KAKENHI-PROJECT-13672340
[Presentation] 衛生薬学的発想と手法で環境問題に挑む2023
- Author(s)
  熊谷嘉人
- Organizer
  第22回分子予防環境医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀に対する生体応答・防御を探る2023
- Author(s)
  熊谷嘉人
- Organizer
  環境省「重金属等による健康影響に関する総合的研究」メチル水銀研究ミーティング
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 生活環境由来カルボン酸が引き起こす新規ヒストンリジンアシル化修飾の探索2023
- Author(s)
  青木康明、則次恒太、高瀬翔平、勝間蒼衣、鈴木健裕、熊谷嘉人、堂前直、伊藤昭博
- Organizer
  日本毒性学会付加体科学部会第１回キックオフシンポジウム
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 細胞外システインは親電子ストレスを制御する2023
- Author(s)
  青木はな子、新開泰弘、小野瀬祐輔、秋山雅博、広瀬玲子、熊谷嘉人
- Organizer
  日本毒性学会付加体科学部会第1回キックオフシンポジウム
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 細胞外のシステインは酸化および親電子ストレスを制御する2023
- Author(s)
  青木はな子、新開泰弘、秋山雅博、山崎聡、西田基宏、熊谷嘉人
- Organizer
  フォーラム2023: 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] Drp1タンパク質のシステイン修飾を介したミトコンドリア過剰分裂を伴う心筋老化2023
- Author(s)
  西村明幸、湯肖康、加藤百合、熊谷嘉人、赤池孝章、西田基宏
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] メタロチオネイン3を誘導する候補薬剤の探索2023
- Author(s)
  水流瑞貴、駒居和起、大内一輝、新開泰弘、木村朋紀、三浦伸彦、熊谷嘉人、保住功、位田雅俊、栗田尚佳
- Organizer
  フォーラム2023: 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K28237
[Presentation] 細胞外における大気中キノン化合物の不活性化に対するシステインの役割2022
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 大気中親電子物質 1,4- ナフトキノンを特異的に認識する抗体を用いたケミカルバイオロジー2022
- Author(s)
  広瀬玲子、安孫子ユミ、新開泰弘、熊谷嘉人
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] イオウ付加体を中間体としたメチル水銀の生体内運命2022
- Author(s)
  安孫子ユミ、熊谷嘉人
- Organizer
  環境省「重金属等による健康影響に関する総合的研究」令和3年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] タバコ副流煙による心筋細胞の老化誘導機構2022
- Author(s)
  湯肖康、西村明幸、西山和宏、加藤百合、伊吹裕子、赤池孝章、熊谷嘉人、西田基宏
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 超硫黄タンパク質としての神経成長抑制因子(GIF/MT3) のレドックス制御2022
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  第2回レドックスR&D戦略委員会春のシンポジウム最先端技術が切り拓くレドックスバイオロジー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Phytochemicals repressing methylmercury risk2022
- Author(s)
  Kumagai Y
- Organizer
  International Conference on Nutrition and Physical Activity in Aging, Obesity and Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 生体側から見た毒性学：親電子ストレスに対する生体応答・防御システム2022
- Author(s)
  熊谷嘉人
- Organizer
  第96回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ニンニクに存在するサルフェン硫黄含有脂肪族炭化水素によるメチル水銀のリスク軽減2022
- Author(s)
  熊谷嘉人
- Organizer
  環境省「重金属等による健康影響に関する総合的研究」令和3年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Environmental stress-induced aberrant mitochondrial fission underlies cardiac vulnerability to mechanical load through Drp1 depolysulfidation2022
- Author(s)
  Akiyuki Nishimura, Kakeru Shimoda, Xiaokang Tang, Kazuhiro Nishiyama, Yuri Kato, Yuko Ibuki, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida
- Organizer
  4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露による細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Redox-dependent alternative internalization (REDAI) of GPCRs2022
- Author(s)
  Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Yuri Kato, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro Nishida
- Organizer
  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Adaptive response and protection against electrophilic stress2022
- Author(s)
  Kumagai Y
- Organizer
  International Conference on New Knowledge and Application of Biomedicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 高濃度メチル水銀曝露によるマウス中枢小胞体ストレス惹起2022
- Author(s)
  野村亮輔、藤村成剛、熊谷嘉人、上原孝
- Organizer
  令和3年度メチル水銀研究ミーティングプログラム（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 限定メタルエキスポソームのモデル化：銅の複合曝露によるメチル水銀毒性の増強2022
- Author(s)
  新開泰弘、秋山雅博、山川寛人、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] レドックスホメオスタシス制御の新たな提案2022
- Author(s)
  熊谷嘉人
- Organizer
  環境省国立水俣病総合研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Phytochemicals repressing methylmercury toxicity2022
- Author(s)
  Kumagai Y
- Organizer
  第49回日本毒性学会学術年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 見落とされてきた神経成長抑制因子（GIF/MT3）の生化学：サルフェン硫黄で制御される亜鉛シグナルの新展開2022
- Author(s)
  熊谷嘉人
- Organizer
  第23回日本亜鉛栄養治療研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] シスチン要求性アンチポーターを介した過剰な活性イオウ分子の細胞外排出.2022
- Author(s)
  青木はな子、秋山雅博、鵜木隆光、蕨英治、西村明幸、西田基宏、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露における細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子ストレスの制御に働くファイトケミカル2022
- Author(s)
  熊谷嘉人
- Organizer
  おかやまバイオアクティブ研究会第60回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] シスチン要求性アンチポーターは硫黄ストレスを制御する2022
- Author(s)
  青木はな子、秋山雅博、鵜木隆光、蕨栄治、西村明幸、西田基宏、熊谷嘉人
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 衛生薬学的発想と手法で環境問題に挑む:親電子ストレスに対する生体応答・防御の解明2022
- Author(s)
  熊谷嘉人
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀誘導性神経毒性メカニズムにおける小胞体ストレス応答の寄与2022
- Author(s)
  野村亮輔、熊谷嘉人、藤村成剛、上原孝
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] スルフォラファンによる GPCR 内在化機構の発見2022
- Author(s)
  西山和宏、西村明幸、下田翔、加藤百合、柴田貴広、熊谷嘉人、赤池孝章、内田浩二、西田基宏
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 神経成長抑制因子(GIF/MT3)の再生を担うタンパク質の発見2022
- Author(s)
  人見颯馬、新開泰弘、熊谷嘉人
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 外来性親電子物質によるエピゲノム調節を介した遺伝子発現変化2022
- Author(s)
  土田知貴、高杉展正、伊藤昭博、熊谷嘉人、上原孝
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 腸内細菌による超硫黄分子産生と酸化ストレス防御への寄与2022
- Author(s)
  秋山雅博、内山純、熊谷嘉人、金倫基
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Mechanism of cardiomyocytes aging due to cigarette sidestream smoke2022
- Author(s)
  Xiaokang Tang, Akiyuki Nishimura, Kazuhiro Nishiyama, Yuri Kato, Yuko Ibuki, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 超硫黄分子による重金属毒性の制御機構2022
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2022
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームの研究戦略2021
- Author(s)
  熊谷嘉人
- Organizer
  第81回日本分析化学会年会・討論会「エクスポゾームと分析化学」
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 銅の複合曝露で生じるレドックスホメオスタシスの破綻とメチル水銀によるタンパク質の化学修飾の増強2021
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  令和2年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子ストレスとそれに対する生体応答・防御システム2021
- Author(s)
  熊谷嘉人
- Organizer
  第1回レドックスR&D戦略委員会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームのモデル化2021
- Author(s)
  熊谷嘉人
- Organizer
  第94回日本薬理学会年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Biochemical strategy to excrete methylmercury out of the body via exhalation: Obligatory role of bismethylmercury sulfide as an intermediate in mice2021
- Author(s)
  Kumagai Y
- Organizer
  pacifichem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 衛生薬学的発想と手法で環境問題に挑む2021
- Author(s)
  熊谷嘉人
- Organizer
  九州大学第2回創薬産学官連携セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄から紐解くメタロチオネインのレドックス制御2021
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会生体金属部会シンポジウム～メタロチオネイン機能の新たな展開～
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 酸化ストレスエクスポソーム：環境化学物質に起因する活性酸素種に着目したアプローチ2021
- Author(s)
  安孫子ユミ、熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Adaptive response and protection against electrophilic stress2021
- Author(s)
  Kumagai Y
- Organizer
  The 9th International Congress of Asian Society of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] HepG2細胞における環境中親電子物質の複合曝露によるNrf2の活性化および細胞毒性への影響2021
- Author(s)
  青木はな子、安孫子ユミ、熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] レドックス生物学におけるアダクトエクスポソームの重要性2021
- Author(s)
  熊谷嘉人
- Organizer
  第94回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 求核分子による大気中キノン化合物の細胞外での捕獲2021
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] HepG2細胞における親電子物質複合曝露によるNrf2活性化および細胞毒性への相加相乗的な影響2021
- Author(s)
  青木はな子、安孫子ユミ、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 鉛はPERK-ATF4経路の活性化によって血管内皮細胞の活性イオウ分子産生を促進させる2021
- Author(s)
  高橋結、藤江智也、宇田川直利、中野毅、新開泰弘、熊谷嘉人、山本千夏、鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Reduction of Arsenic Toxicity Through Nuclear Factor E2 Related Factor 2 Activation Mediated by The (E)-2-Alkenals in Coriandrum Sativum L. Leaf Extract2021
- Author(s)
  Aoki H、Abiko Y、Okada M、Mizokawa M、Kumagai Y
- Organizer
  11th Congress of Toxicology in Developing Countries (CTDC11)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露による脳中水銀蓄積と中毒症状は活性イオウ分子産生酵素CSEにより抑制される2021
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、石井功、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 1,2-ナフトキノンによるN-アリール化を介したEGFR活性化機構2021
- Author(s)
  土田知貴、中原健吾、熊谷嘉人、上原孝
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 腸内細菌由来活性イオウ分子が宿主の抗酸化能に及ぼす影響2021
- Author(s)
  内山純、秋山雅博、熊谷嘉人、金倫基
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE: Two sides of the same coin in protection against electrophilic stress as a category of oxidative stress2021
- Author(s)
  Kumagai Yoshito
- Organizer
  The Society of Toxicology’s 59th Annual Meeting: The SOT/JSOT Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄を介したメタロチオネイン-3のレドックス制御2021
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄結合タンパク質としてのメタロチオネイン：見落とされてきたレドックス制御システム2021
- Author(s)
  熊谷嘉人
- Organizer
  新学術領域研究「生命金属科学」領域会議
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Hexane Extract of Garlic Suppresses Methylmercury Mediated Toxicity2021
- Author(s)
  Abiko Y、Katayama Y、Akiyama M、Kumagai Y
- Organizer
  11th Congress of Toxicology in Developing Countries (CTDC11)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露によるマウス脳内小胞体ストレス応答2021
- Author(s)
  野村亮輔、平岡秀樹、熊谷嘉人、藤村成剛、上原孝
- Organizer
  第48回日本毒性学会学術年会（神戸・オンライン）
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] TGF-β1-ALK5-Smad2/3/4-ATF4経路を介した活性イオウ分子の増加はTGF-β1の血管内皮細胞増殖抑制作用をmodulateする2021
- Author(s)
  高橋結、藤江智也、中野毅、新開泰弘、熊谷嘉人、山本千夏、鍜冶利幸
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Adaptive response and protection against electrophilic stress2021
- Author(s)
  Kumagai Yoshito
- Organizer
  The 24th SANKEN International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 大気中キノン化合物の細胞外での捕獲：フェーズゼロ反応の提案2021
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] A431細胞における親電子物質複合曝露によるEGFR活性化2021
- Author(s)
  安孫子ユミ、黒澤航軌、山川寛人、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 1,2-ナフトキノンによるN-アリール化を介したEGFR-Aktシグナリング活性化機構の解析2021
- Author(s)
  土田知貴、中原健吾、熊谷嘉人、上原孝
- Organizer
  生体機能と創薬シンポジウム2021（北海道大学・オンライン）
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ニンニク中活性イオウ分子によるメチル水銀毒性の軽減2021
- Author(s)
  安孫子ユミ、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2021
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子物質複合曝露によるKeap1/Nrf2システムの活性化および毒性の亢進2020
- Author(s)
  青木はな子、安孫子ユミ、小野瀬祐輔、熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀毒性を制御する低分子の今昔．2020
- Author(s)
  熊谷嘉人
- Organizer
  環境省　国立水俣病総合研究センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Adaptive response and protection against electrophilic stress2020
- Author(s)
  Kumagai Yoshito
- Organizer
  The 1st International Virtual Forum on Modern Toxicology: A2020 Vision
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子ストレスに対する細胞外での意外な防御応答機構2020
- Author(s)
  小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 細胞内外のレドックスホメオスタシスを制御するアンチポーター2020
- Author(s)
  秋山雅博、鵜木隆光、青木はな子、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 金属の複合曝露で生じるレドックスホメオスタシスの破綻とそれに起因するタンパク質の化学修飾の増強2020
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 重金属/必須微量元素の複合曝露影響（メタルエクスポソーム）のモデル化．2020
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子物質(E)-2-alkenal 類を含有する C. sativum L. 抽出液による Nrf2 活性化と細胞中ヒ素濃度の減少2020
- Author(s)
  安孫子ユミ、青木はな子、岡田美幸、溝河真衣、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質に対する細胞外生体防御機構の実証．2020
- Author(s)
  小野瀬祐輔、秋山雅博、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子の細胞外排出機構．2020
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、本橋ほづみ、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 銅の複合曝露で生じるレドックスホメオスタシスの破綻とメチル水銀毒性の増強2020
- Author(s)
  秋山雅博、山川寛人、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] レドックスサイクル能を有する多環芳香族炭化水素:多彩なROSの産生機構と細胞内シグナル系とのクロストーク2020
- Author(s)
  熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ラマン分光法を用いたメタロチオネイン -3 の分子構造解析2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、Sumeet Mahajan、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質の毒性防御に働くシグナル伝達経路と活性イオウ分子による制御2020
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀の毒性を制御する活性イオウ分子2020
- Author(s)
  熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子性金属を中心としてメタルエクスポソームのモデル化2020
- Author(s)
  秋山雅博、山川寛人、熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄結合タンパク質の同定とその機能解析．2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、井田智章、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子を介した親電子ストレス防御2020
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、熊谷嘉人、藤村成剛
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子の脳内分布とメチル水銀感受性の連関2020
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] タンパク質修飾能を有する化学物質を対象とした限定エクスポソームのモデル化2020
- Author(s)
  熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 複合曝露評価の新たな手法．2020
- Author(s)
  熊谷嘉人
- Organizer
  日本学術会議公開シンポジウム　複合曝露とHuman Biomonitoring
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄によるレドックス制御と環境中親電子物質のフェーズゼロ反応2020
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出機構によるレドックス恒常性維持とフェーズゼロ反2020
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、西田基宏、本橋ほずみ、赤池孝章、熊谷嘉人
- Organizer
  第73回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀による部位特異的神経障害における小胞体ストレスの寄与2020
- Author(s)
  平岡秀樹、岩脇隆夫、熊谷嘉人、藤村成剛、上原孝
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] パースルフィドの新たな機能：親電子ストレスを制御する細胞外システム2020
- Author(s)
  熊谷嘉人
- Organizer
  第73回日本酸化ストレス学会・第20回日本NO学会合同学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄(sulfane sulfur)結合タンパク質としてのメタロチオネイン -3 の分子構造解析2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、Sumeet Mahajan 、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Involvement of PI3K-Akt Signaling in Antiapoptotic Effect Evoked by 1,2-Naphthoquinone2019
- Author(s)
  Nakahara K、Hiraoka H、Hamada K、Kumagai Y、Uehara T
- Organizer
  IUTOX ICTXV 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] CSEとNrf2は異なる経路を介して親電子ストレスを抑制する鍵分子である．2019
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、熊谷嘉人
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Identification, characterization and a three-dimensional structure modeling of metallothionein-3 as a sulfane sulfur- and zinc-binding protein.2019
- Author(s)
  Shinkai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Unoki Takamitsu、Ida Tomoaki、Akaike Takaaki、Jon M. Fukuto、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メタロチオネイン研究のパラダイムシフト.2019
- Author(s)
  熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームのモデル化：1,4-NQ 依存的なPTP1B/EGFRシグナル活性化における1,2-NQ 複合曝露影響．2019
- Author(s)
  安孫子ユミ、黒澤航軌、山川寛人、熊谷嘉人
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Identification and characterization of metallothionein-3 as a pesulfide binding protein2019
- Author(s)
  Yunjie Ding、Shinaki Yasuhiro、Kumagai Yoshito
- Organizer
  Society of Toxicology 58th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質に対する生体応答とそれを制御する活性イオウ分子.2019
- Author(s)
  熊谷嘉人
- Organizer
  第22回日本環境ホルモン学会研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Jon M Fukuto、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出輸送機構によるレドックス制御.2019
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、新開泰弘、安孫子ユミ、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子による親電子シグナル制御系の破綻に起因する有機水銀の神経毒性発現機構．2019
- Author(s)
  笠松真吾、西田基宏、澤智裕、熊谷嘉人、赤池孝章、居原秀
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームのモデル化：A431細胞における1,4-NQ依存的PTP1B/EGFRシグナル活性化に対する1,2-NQ複合曝露の影響.2019
- Author(s)
  黒澤航軌、山川寛人、安孫子ユミ、熊谷嘉人
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Unique adaptive response to electrophilic stress2019
- Author(s)
  Kumagai Yoshito
- Organizer
  Seminar on biovailability of arsenic at Department of Toxicology of Zhejiang University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] フェーズゼロ反応：活性イオウ分子を利用した化学物質の不活性化というパラダイムシフト．2019
- Author(s)
  熊谷嘉人
- Organizer
  第46回日本毒性学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームのモデル化: 親電子物質複合曝露によるKeap1/Nrf2 システム活性化の相加相乗的な変動．2019
- Author(s)
  青木はな子、小野瀬祐輔、安孫子ユミ、熊谷嘉人
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for repression of environmental electrophile-mediated toxicity in mice.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 酸化・親電子ストレスとそれを制御する活性イオウ分子2019
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メタルエキスポソームのモデル化．2019
- Author(s)
  秋山雅博、山川寛人、小野瀬祐輔、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 重金属の毒性に対する血管内皮細胞の防御システム．2019
- Author(s)
  新開泰弘、熊谷嘉人
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Molecular Mechanism of Methylmercury-Induced Neurotoxicity via Endoplasmic Reticulum Stress2019
- Author(s)
  Hiraoka H、Nakahara K、Takasugi N、Fujimura M、Iwawaki T、Kumagai Y、Uehara T
- Organizer
  IUTOX ICTXV 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of redox signaling pathways mediated by xenobiotic electrophiles.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  The 10th International Conference on Nutrition and Physical Activity on Aging, Obesity and Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  IUTOX 15th International Congress of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE: Two sides of the same coin in protection against electrophilic stress.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Phase-zero reaction as a primary defense systeme against electrophilic stress in out of cell: Involvement of reactive persulfides.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Warabi Eiji、Shinkai Yasuhiro、Abiko Yumi、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子との反応を介したメチル水銀の解毒・排泄における反応中間体としてのイオウ付加体．2019
- Author(s)
  安孫子ユミ、片山優助、熊谷嘉人
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 1,4-Naphthoquinone-mediated activation of PTEN/Akt/CREB signaling and cytotoxicity are negatively regulated by sodium tetrasulfide.2019
- Author(s)
  Hirose Reiko、Abiko Yumi、Shinkai Yasuhiro、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfide and polysulfide species in plants to detoxify methylmercury.2019
- Author(s)
  Abiko Yumi、Katayama Yusuke、Kumagai Yoshito
- Organizer
  IUTOX 15th International Congress of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Understanding Adaptive Response to Electrophilic Stress.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  2019 KSOT/KEMS Toxicology Workshop & Spring International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 酸化・親電子ストレスとそれを制御する活性イオウ分子2019
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] メチル水銀の細胞傷害特異性に対する含イオウ求核低分子の影響．2019
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 小胞体ストレス応答可視化マウスを用いた脳内メチル水銀応答解析2019
- Author(s)
  平岡秀樹、岩脇隆夫、熊谷嘉人、藤村成剛、上原孝
- Organizer
  メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄結合タンパク質としてのメタロチオネイン-3 の機能と3 次元構造モデリング．2019
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] A 3D structure modeling of metallothionein-3 and its related function as a sulfane sulfur binding protein．2019
- Author(s)
  Yunjie Ding、Shinkai Yasuhiro、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] S-Sulfuration of Cys215 is required for reversibility of PTP1B activity.2019
- Author(s)
  Kumagai Yoshito、Abiko Yumi、Nho Cong Luong
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] カドミウム誘導性の生体応答および肝毒性は活性イオウ分子によって抑制される．2019
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Metallothionein-3 as a sulfur binding protein: Identification, characterization and 3D structure modeling.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] The obligatory role of the S-sulfuration in reversibility of PTP1B activity.2019
- Author(s)
  Abiko Yumi、Nho C. Luong、Jon M. Fukuto、Funato Y、Miki H、Eva Doka、Markus Dagnell、Ida Tomoaki、Noemi Balog、Belen Espinosa、Nishimura A、Justin R. Prigge、Edward E. Schmidt、Elias S. J. Arner、Akaike Takaaki、 Peter Nagy、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 心筋梗塞後のマウス心臓におけるミトコンドリアーアクチン相互作用の病態生理学的意義2019
- Author(s)
  田中智弘、西村明幸、下田翔、島内司、外山喬士、北島直幸、石川達也、進藤直哉、冨田拓郎、安田智、佐藤陽治、桑原宏一郎、熊谷嘉人、赤池孝章、井手友美、王子田彰夫、森泰生、西田基宏
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamto Masayuki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Regulation of electrophilic stress by reactive persulfide released in out of cell:Phase-zero reaction.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamizu、Warabi Eiji、Shinkai Yasuhiro、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Role of sulfane sulfur in metallothionein-3 as a model zinc-binding protein.2019
- Author(s)
  Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 亜鉛結合タンパク質のモデルとしてのメタロチオネイン-3 におけるサルフェン硫黄の役割．2019
- Author(s)
  Yunjie Ding、新開泰弘、秋山雅博、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] A paradigm shift to redox signal regulation by reactive sulfur species from metallothionein-32019
- Author(s)
  Kumagai Yoshito
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀誘発性神経障害における小胞体ストレスの寄与．2019
- Author(s)
  平岡秀樹、藤村成剛、岩脇隆夫、熊谷嘉人、上原孝
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Electrophilic stress: Good or Bad?2018
- Author(s)
  Kumagai Yoshito
- Organizer
  Environmental Health Conference 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子によるカドミウムのイオウ付加体の生成を介した毒性防御2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人
- Organizer
  生理学研究所研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子を基軸とする有害金属研究の新展開2018
- Author(s)
  熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームと防御応答・適応2018
- Author(s)
  熊谷嘉人
- Organizer
  生理学研究所　研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 新しいレドックス反応：パースルフィドはキノン系化合物を一電子還元する2018
- Author(s)
  安孫子ユミ、中井由実、Luong Cong Nho、Fukuto M Jon、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ケミカルバイオロジーを基盤とした酸化・親電子ストレスを生じる化学物質の毒性学的研究2018
- Author(s)
  熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 鉛による内皮細胞の活性イオウ分子合成関連酵素の発現異常2018
- Author(s)
  宇田川直利、藤江智也、熊谷嘉人、山本千夏、鍜冶利幸
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] パースルフィド・ポリスルフィドとの反応を介した環境中電子受容体のレドックスサイクルで生じるチイルラジカル2018
- Author(s)
  安孫子ユミ、中井由実、Nho Cong LUONG、Jon M FUKUTO、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of redox signal transduction pathways mediated by electrophilic metals2018
- Author(s)
  Kumagai Yoshito
- Organizer
  10th Congress of Toxicology in Developing Countries
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] エクスポソームと生命環境応答・適応2018
- Author(s)
  熊谷嘉人
- Organizer
  第71回日本酸化ストレス学会・第18回日本NO学会合同学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] エクスポソームと生命環境応答・適応2018
- Author(s)
  熊谷嘉人
- Organizer
  第71回日本酸化ストレス学会・第18回日本NO学会合同学術集会、日本NO学会企画シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H04133
[Presentation] 活性イオウ分子種定量解析システムの開発と新しいシステインパースルフィド合成酵素の発見2018
- Author(s)
  井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、居原　秀、澤　智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
- Organizer
  第17回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Nrf2およびCSE は環境中親電子物質によるマウス肝細胞毒性の抑制に必須である2018
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfide as a protection factor to block peroxidation of protein cysteine residue2018
- Author(s)
  Nho Cong Luong、Abiko Yumi、Kumagai Yoshito
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀による活性イオウ分子種依存的レドックスシグナルの破綻2018
- Author(s)
  居原秀、北村篤志、笠松真吾、井田智章、西田基宏、澤智裕、熊谷嘉人、赤池孝章
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] ケミカルバイオロジーを基盤とした酸化・親電子ストレスを生じる化学物質の毒性学的研究2018
- Author(s)
  熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] CSEとNrf2は異なる経路を介して親電子性重金属毒性を抑制する鍵分子である2018
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] マウスにおけるメチル水銀の生体内変換：活性イオウ分子で生じる代謝中間体を用いた検討2018
- Author(s)
  片山優助、安孫子ユミ、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of Epidermal Growth Factor Receptor Signaling Through S-oxidation of Protein Tyrosine Phosphatase 1B in A431 Cells by Reactive Oxygen Species Produced from 9 10-Phenanthrenequinone2018
- Author(s)
  Luong Cong Nho、Abiko Yumi、Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄（sulfane sulfur）結合タンパク質としてのメタロチオネイン：レドックス制御に関する新たな提案2018
- Author(s)
  熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Identification of a Sulfur Adduct of 1,4-Naphthoquinone during Reaction with a Polysulfide2018
- Author(s)
  R Hirose, Y Shinkai, Y Abiko, Y Kumagai
- Organizer
  Society of Toxicology 57th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] サルフェン硫黄（sulfane sulfur）結合タンパク質としてのメタロチオネイン：レドックス制御に関する新たな提案2018
- Author(s)
  熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Invited
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 無機亜鉛の内皮細胞毒性に対する活性イオウ分子産生酵素の役割2018
- Author(s)
  毛塚彩、吉田映子、新開泰弘、熊谷嘉人、鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質エクスポソームと防御応答・適応2018
- Author(s)
  熊谷嘉人
- Organizer
  生理学研究所　研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
- Invited
- Data Source
  KAKENHI-PROJECT-18H04133
[Presentation] ポリスルフィドによるカドミウムの不活性化を介した肝毒性の防御機構2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄（sulfane sulfur）結合タンパク質としてのメタロチオネイン-3の同定とその機能解析2018
- Author(s)
  新開泰弘、Yunjie Ding、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] 1,4-NQ-Mediated Activation of PTEN/Akt/CREB Signaling in Primary Mouse Hepatocytes2018
- Author(s)
  Y Abiko, Y Shinkai, T Unoki, R Hirose, T Uehara, Y Kumagai
- Organizer
  Society of Toxicology 57th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 血管内皮細胞のメタロチオネイン転写誘導機構の解析への有機－無機ハイブリッド分子の活用2018
- Author(s)
  竹中福太、吉田映子、藤江智也、山本千夏、藤原泰之、熊谷嘉人、鍜冶利幸
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Activation of Epidermal Growth Factor Receptor Signaling Through S-oxidation of Protein Tyrosine Phosphatase 1B in A431 Cells by Reactive Oxygen Species Produced from 9 10-Phenanthrenequinone2018
- Author(s)
  Luong Cong Nho、Abiko Y、Kumagai Y
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Modulation of unfolded protein response by methylmercury2018
- Author(s)
  Hideki Hiraoka、Kengo Nakahara、Kosaku Okuda、Yoshito Kumagai、Takashi Uehara
- Organizer
  WCP2018 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Electrophilic stress regulated by reactive sulfur species2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 10th International Conference on Home Oxygenase 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfide as a protection factor to block peroxidation of protein cysteine residue2018
- Author(s)
  Nho Cong Luong、Abiko Y、Kumagai Y
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Nrf2 とCSE はメチル水銀中毒症状を抑制する鍵分子である2018
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄（sulfane sulfur）結合タンパク質としてのメタロチオネイン-3の同定とその機能解析2018
- Author(s)
  新開泰弘、Yunjie Ding、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Environmental electrophiles and reactive sulfur species: implications to regulation of redox signaling and toxicity2018
- Author(s)
  Kumagai Y
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性の防御機構2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Cystathionine Gamma-Lyase Is a Key Protein Repressing Methylmercury Poisoning Symptoms in Mice2018
- Author(s)
  M Akiyama, Y Shinkai, I Ishii, T Akaike, Y Kumagai
- Organizer
  Society of Toxicology 57th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子：親電子ストレスに対する防御的役割とその細胞内過剰蓄積による還元ストレス2018
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、新開泰弘、石井功、赤池孝章、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Electrophilic stress regulated by reactive sulfur species2018
- Author(s)
  Kumagai Y
- Organizer
  The 10th International Conference on Home Oxygenase 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Electrophilic stress: Good or bad?2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 6th Conference of the Japanese Association for Hypoxia Biology International Symposium for Innovative Areas Oxygen Biology and New Insights into Ion Channel Functions and Pharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfides and Polysulfides as Phytochemicals to Detoxify MeHg2018
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Electrophilic stress: Good or Bad?2018
- Author(s)
  Kumagai Y
- Organizer
  Environmental Health Conference 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Activation of redox signal transduction pathways mediated by electrophilic metals2018
- Author(s)
  Kumagai Y
- Organizer
  10th Congress of Toxicology in Developing Countries
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04133
[Presentation] A variety of adaptive responses to atmospheric electrophiles2018
- Author(s)
  Kumagai Yoshito
- Organizer
  Tsukuba Global Science Week 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Cadmium-Mediated Activation of the HSP90/ HSF1 Pathway Regulated by Reactive Persulfides and Polysulfides2018
- Author(s)
  Y Shinkai, A Masuda, M Akiyama, M Xian, Y Kumagai
- Organizer
  Society of Toxicology 57th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀による小胞体ストレスを介した細胞死惹起機構2018
- Author(s)
  平岡秀樹、中原健吾、藤村成剛、岩脇隆夫、熊谷嘉人、上原孝
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] パースルフィド・ポリスルフィドとの反応を介した環境中電子受容体のレドックスサイクルで生じるチイルラジカル2018
- Author(s)
  安孫子ユミ、中井由実、Nho Cong LUONG、Jon M FUKUTO、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Environmental electrophiles and reactive sulfur species: implications to regulation of redox signaling and toxicity2018
- Author(s)
  Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子解毒代謝系システインパースルフィドの新しい合成酵素の発見2018
- Author(s)
  井田智章、守田匡伸、西村明、松永哲郎、居原秀、澤智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 新しいレドックス反応：パースルフィドはキノン系化合物を一電子還元する2018
- Author(s)
  安孫子ユミ、中井由実、Luong Cong Nho、Fukuto M Jon、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Methylmercury(MeHg)-induced neuronal cell death via unfolded protein response2018
- Author(s)
  H.HIRAOKA、K.NAKAHARA、M.FUJIMURA、Y.KUMAGAI、T.UEHARA
- Organizer
  Society for Neuroscience 2018（SfN 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 食用植物に含まれる活性イオウ分子種がメチル水銀毒性を低毒性化する2018
- Author(s)
  片山優助、安孫子ユミ、秋山雅博、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Understanding unique adaptive response to electrophilic stress2018
- Author(s)
  Kumagai Yoshito
- Organizer
  BiomedicMedicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メタロチオネイン-3の意外な機能：可動性イオウによるメチル水銀の捕獲・不活性化2018
- Author(s)
  Yunjie Ding、新開泰弘、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Molecular mechanism of Akt signaling evoked by 1,2-naphthoquinone2018
- Author(s)
  Kengo Nakahara、Hideki Hiraoka、Kyohei Hamada、Yoshito Kumagai、Takashi Uehara
- Organizer
  WCP2018 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子ストレスを制御するレドックスシグナル伝達と活性イオウ分子2017
- Author(s)
  熊谷嘉人
- Organizer
  第39回日本薬学会九州支部コロキウム
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子性金属に対する新たな防御応答システムの提案2017
- Author(s)
  熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀のケミカルバイオロジー2017
- Author(s)
  熊谷嘉人.
- Organizer
  基盤（S）公開シンポジウムメチル水銀研究の現状と展望
- Place of Presentation
  一の坊（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 水銀が操る生体応答とトキシコロジー2017
- Author(s)
  熊谷嘉人
- Organizer
  第17回日本抗加齢医学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] レドックスシグナル伝達の可逆性担保における活性イオウ分子の役割.2017
- Author(s)
  熊谷嘉人
- Organizer
  第4回新学術領域研究「酸素生物学」全体班会議・公開シンポジウム
- Place of Presentation
  九州大学（福岡県、福岡市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] Environmental electrophiles activate redox signaling transduction pathways through covalent modification of sensor proteins2017
- Author(s)
  Abiko Y, Kumagai Y
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー日韓次世代シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 9,10- フェナントラキノンにより生じた活性酸素種によるプロテインチロシンフォスファターゼ活性阻害に対するパースルフィドおよびポリスルフィドの保護効果．2017
- Author(s)
  Luong Cong Nho、安孫子ユミ、熊谷嘉人．
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] 活性イオウ分子はカドミウムの不活性化を介して生体応答および肝毒性の惹起を負に制御する2017
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] The phase-zero reaction: capture and inactivation of electrophiles by persulfides2017
- Author(s)
  Kumagai Y
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] ビスメチル水銀スルフィドの生成を介したニンニクのヘキサン抽出成分によるメチル水銀の毒性軽減2017
- Author(s)
  Yunjie DING、安孫子ユミ、秋山雅博、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017
- Author(s)
  小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化と活性イオウ分子によるその制御2017
- Author(s)
  鵜木隆光、新開泰弘、増田章、秋山雅博、Ming XIAN、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 8-ニトロ-cGMPとタンパク質poly-S-グアニル化を介した親電子シグナル制御2017
- Author(s)
  赤司壮一郎、笠松真吾、ジョン　ミンギョン、松永哲郎、井田智章、藤井重元、澤　智裕、熊谷嘉人、本橋ほづみ、赤池孝章
- Organizer
  2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子を介したカドミウムの肝毒性の防御機構2017
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] ポリスルフィドNa2S4はイオウ付加体形成を通じて1,4-NQによる PTEN/ Akt/CREB シグナルの活性化と細胞毒性を抑制する2017
- Author(s)
  鵜木隆光、安孫子ユミ、新開泰弘、広瀬玲子、上原孝、熊谷嘉人
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] The chemical biology of environmental electrophiles2017
- Author(s)
  Kumagai Y
- Organizer
  Special seminar at University of Bordeaux school of Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] マウスにおけるアクリルアミドの神経毒性に対する活性イオウ分子の役割2017
- Author(s)
  秋山雅博、安孫子ユミ、熊谷嘉人
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] アセトアミノフェン投与マウスにおけるアセトアミノフェンーイオウ付加体：新しい解毒機構.2017
- Author(s)
  安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
- Organizer
  第16回分子予防環境医学研究会
- Place of Presentation
  熊本市国際交流会館（熊本県、熊本市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムによるHSP90の化学修飾を介する転写因子HSF1の活性化と活性イオウ分子によるその制御2017
- Author(s)
  鵜木隆光、新開泰弘、増田章、秋山雅博、Xian Ming、熊谷嘉人
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀を低毒性化する食用植物中生理活性物質としてのper/polysulfides2017
- Author(s)
  片山優助、安孫子ユミ、秋山雅博、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化はポリサルファイドモデル化合物Na2S4により抑制される2017
- Author(s)
  安孫子ユミ、新開泰弘、鵜木隆光、広瀬怜子、上原孝、熊谷嘉人
- Organizer
  第70回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性および生体応答の制御2017
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive persulfide-dependent redox signaling in neuronal cells and its impairment by exposure to electrophiles2017
- Author(s)
  Shigemoto Fujii, Hideshi Ihara, Shingo Kasamatsu, Akira Nishimura, Tomoaki Ida, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
- Organizer
  8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] マウスにおけるアクリルアミドの神経毒性に対するCSEの役割2017
- Author(s)
  秋山雅博、安孫子ユミ、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] ポリサルファイドモデル化合物Na2S4は1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化を抑制する2017
- Author(s)
  安孫子ユミ、新開泰弘、鵜木隆光、広瀬玲子、上原孝、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 新規システインパースルフィド合成酵素の同定と機能解析2017
- Author(s)
  井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、Jung Minkyung、赤司壮一郎、居原　秀、澤　智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中電子受容体とパースルフィドとの反応で生じるパーチイルラジカル．2017
- Author(s)
  安孫子ユミ、中井由実、Luong Cong Nho、熊谷嘉人．
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] The chemical biolgy of environmental electrophiles2017
- Author(s)
  Kumagai Y
- Organizer
  Special seminar at National Taiwan University of School of Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 高血糖誘発性心不全の改善メカニズムにおけるTRPC6チャネルの役割2017
- Author(s)
  小田紗矢香、冨田拓郎、北島直幸、外山喬士、原田英里、島内司、西村明幸、石川達也、熊谷嘉人、Lutz Birnbaumer、西田基宏
- Organizer
  TRP研究会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Environmental electrophile exposure and health2017
- Author(s)
  Kumagai Y
- Organizer
  National Conference of Toxicology2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 新しいシステインパースルフィド産生酵素の同定と機能解析2017
- Author(s)
  井田智章、守田匡伸、魏　范研、松永哲郎、西村　明、Jung Minkyung、赤司壮一郎、居原　秀、澤　智裕、藤井重元、熊谷嘉人、富澤一仁、本橋ほづみ、赤池孝章
- Organizer
  2017年度生理学研究所研究会「オルガネラダイナミクスの新規制御機構とその病態生理」
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子およびその産生酵素は1,4-NQ曝露によるHSP90/HSF1シグナルの活性化を抑制する2017
- Author(s)
  広瀬玲子、安孫子ユミ、新開泰弘、鵜木隆光、土屋幸弘、渡邊泰男、赤池孝章、熊谷嘉人
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive oxygen species produced from 9,10-phenanthrenequinone activate epidermal growth factor receptor signaling through oxidative modification of protein tyrosine phosphatase 1B.2017
- Author(s)
  Luong Cong Nho, Abiko Y, Kumagai Y.
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PUBLICLY-17H05519
[Presentation] Environmental electrophiles: Modulation of redox signaling and interaction with persulfides/polysulfides.2017
- Author(s)
  熊谷嘉人.
- Organizer
  第90回日本細菌学会総会国際シンポジウム
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Is environmental electrophile an essential item for exposome?2017
- Author(s)
  Kumagai Y
- Organizer
  第44回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] CSE 欠損による親電子ストレスに対する感受性増強と CSE 高発現による還元ストレスに対する生体応答2017
- Author(s)
  秋山雅博、蕨栄治、鵜木隆光、新開泰弘、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Capture of methylmercury by persulfides to form bismethylmercury sulfide.2016
- Author(s)
  Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
- Organizer
  IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
- Place of Presentation
  Convention Center in Merida (Merida, Mexico)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質によるレドックスシグナル伝達の活性化と破綻.2016
- Author(s)
  熊谷嘉人
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] The phase-zero reaction: capture of electrophiles mediated by reactive sulfur species.2016
- Author(s)
  Kumagai Y.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Stoweflake Conference Center (Stowe, USA)
- Year and Date
  2016-08-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質によるレドックスシグナル伝達の活性化と破綻.2016
- Author(s)
  熊谷嘉人.
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子プローブを用いたMRM-MS による生体試料中の活性イオウ分子の定量法の構築.2016
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、井田智章、赤池孝章、熊谷嘉人.
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都、品川区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Translation-coupled protein polysulfuration, a unique biosynthesis pathway of cysteine persulfide.2016
- Author(s)
  Ida T, Ihara H, Wei F, Tomozawa K, Kasamatsu S, Morita M, Matsunaga T, Kumagai Y, Sawa T, Motohashi H, Fujii S, Akaike T.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムによるHSP90の化学修飾を介した転写因子HSF1の活性化とその防御的役割.2016
- Author(s)
  新開泰弘、増田章、熊谷嘉人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県、名古屋市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Cystathionine gamma-lyase はメチル水銀中毒症状を抑制する鍵分子である.2016
- Author(s)
  秋山雅博、安孫子ユミ、新開泰弘、鵜木隆光、Ding Yunjie、外山喬士、吉田映子、熊谷嘉人.
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都、品川区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子によるカドミウムの毒性防御の分子機構.2016
- Author(s)
  新開泰弘、熊谷嘉人.
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質/電子受容体で活性イオウ分子の役割を探る.2016
- Author(s)
  熊谷嘉人
- Organizer
  第12回レドックスイノベーションシンポジウム
- Place of Presentation
  熊本大学（熊本県、熊本市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] 親電子・活性イオウ分子付加体の化学と解析法.2016
- Author(s)
  安孫子ユミ、新開泰弘、熊谷嘉人.
- Organizer
  新学術領域研究｢酸素生物学｣第3回技術支援セミナー
- Place of Presentation
  名古屋大学シンポジオン（愛知県・名古屋市）
- Year and Date
  2016-01-23
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Generation of cystathionine γ-lyase overexpressing Tg mouse.2016
- Author(s)
  Warabi E, Kumagai Y.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Methylmercury activates and disrupts the Akt/CREB/Bcl-2 signal transduction pathway in SH-SYSY cells.2016
- Author(s)
  Kumagai Y, Unoki T, Abiko Y, Toyama T.
- Organizer
  The 52nd European Congress of the European Societies of Toxicology
- Place of Presentation
  FEBES, Conference and Exhibition Centre (Seville, Spain)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 1,4-Naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its negative regulation by reactive sulfur species in human A431 cells.2016
- Author(s)
  Unoki T, Shinkai Y, Sha L, Hirose R, Kumagai Y.
- Organizer
  IUTOX2016 XIV International Congress of Toxicology and X Mexican Congress of Toxicology
- Place of Presentation
  Convention Center in Merida (Merida, Mexico)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中に存在する親電子物質および電子受容体で活性イオウ分子の役割を探る.2016
- Author(s)
  熊谷嘉人
- Organizer
  オルガネラ研究会2016
- Place of Presentation
  生理学研究所（愛知県、岡崎市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] 1,4-naphthoquinone-mediated activation of the HSP90/HSF1 signal transduction pathway and its modulation by reactive sulfur species in human A431 cells.2016
- Author(s)
  Unoki T, Shinkai Y, Sha L, Kumagai Y.
- Organizer
  Society of Toxicology 55th Annual Meeting
- Place of Presentation
  New Orleans（アメリカ）
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive sulfur species as a regulator molecule for the phase-zero reaction to attenuate reactivity of electrophiles.2016
- Author(s)
  Kumagai Y
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] アセトアミノフェンの新規代謝経路：イオウ付加体の同定.2016
- Author(s)
  安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県、名古屋市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Coriandrum sativum L.葉抽出液中の脂肪族親電子物質によるNrf2活性化および無機三価ヒ素の細胞毒性軽減.2016
- Author(s)
  安孫子ユミ、溝河真衣、里見綾香、熊谷嘉人.
- Organizer
  第22回ヒ素シンポジウム
- Place of Presentation
  産総研臨界副都心センター（東京都、港区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子によるカドミウムの毒性防御.2016
- Author(s)
  鵜木隆光、新開泰弘、秋山雅博、熊谷嘉人.
- Organizer
  第32回臨床フリーラジカル会議
- Place of Presentation
  京都・烟河（京都府・亀岡市）
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Protein poly-S-guanylation: Reversible post-translational modification regulated by protein polysulfur and 8-nitrocGMP.2016
- Author(s)
  Akashi S, Kasamatsu S, Jung M, Matsunaga T, Ida T, Fujii S, Sawa T, Kumagai Y, Motohashi H, Akaike T.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Role of reactive sulfur species as a key molecule to diminish toxicity of the environmental electrophile in mice.2016
- Author(s)
  Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中に存在する親電子物質および電子受容体で活性イオウ分子の役割を探る.2016
- Author(s)
  熊谷嘉人.
- Organizer
  オルガネラ研究会2016
- Place of Presentation
  生理学研究所（愛知県、岡崎市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質による生体影響の二面性：SH-SY5Y 細胞におけるメチル水銀曝露により生じるAkt/CREB/Bcl-2 経路の活性化と破綻.2016
- Author(s)
  鵜木隆光、安孫子ユミ、外山喬士、上原孝、坪井康次、西田基宏、鍜冶利幸、熊谷嘉人.
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都、品川区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Protective effect of sodium tetrasulfide on covalent modification of cellular proteins and cellular toxicity mediated by 1,4-naphthoquinone, an atmospheric electrophile.2016
- Author(s)
  Hirose R, Unoki T, Shinkai Y, Abiko Y, Kumagai Y.
- Organizer
  Society of Toxicology 55th Annual Meeting
- Place of Presentation
  New Orleans（アメリカ）
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀曝露による健康リスクを制御する活性イオウ分子の役割.2016
- Author(s)
  秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県、名古屋市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子シグナルを制御する活性イオウ分子.2016
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会第136年会（横浜）2016年3/28
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 1,4-ナフトキノンによるHSF90/HSF1経路の活性化と活性イオウ分子によるその制御.2016
- Author(s)
  鵜木隆光、新開泰弘、沙亮、広瀬玲子、熊谷嘉人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県、名古屋市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Paraquat-generated reactive oxygen species activate epidermal growth factor receptor signaling pathway in A431 cells.2016
- Author(s)
  Luong CN, Abiko Y, Kumagai Y.
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都、品川区）
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] カドミウムの肝毒性に対する活性イオウ分子の防御的役割.2016
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人.
- Organizer
  オルガネラ研究会2016
- Place of Presentation
  生理学研究所（愛知県、岡崎市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] The chemical biology of electrophiles and reactive sulfur species.2016
- Author(s)
  Kumagai Y.
- Organizer
  The special seminar for visiting professor of China Medical University
- Place of Presentation
  China Medical University（Shenyang, China）
- Year and Date
  2016-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Activation of Nrf2 through S-transmerculation of methylmercury glutathione adduct to Keap1 in SH-SY5Y cells.2016
- Author(s)
  Abiko Y, Yoshida E, Kumagai Y.
- Organizer
  Society of Toxicology 55th Annual Meeting
- Place of Presentation
  New Orleans（アメリカ）
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質/電子受容体で活性イオウ分子の役割を探る.2016
- Author(s)
  熊谷嘉人.
- Organizer
  第12回レドックスイノベーションシンポジウム
- Place of Presentation
  熊本大学（熊本県、熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムによるレドックスシグナル伝達経路の活性化とその制御系.2016
- Author(s)
  新開泰弘、熊谷嘉人.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Role of cystathionine gamma-lyase in the health risks of methylmercury.2016
- Author(s)
  Akiyama M, Toyama T, Yoshida E, Unoki T, Abiko Y, Shinkai Y, Kumagai Y.
- Organizer
  Society of Toxicology 55th Annual Meeting
- Place of Presentation
  New Orleans（アメリカ）
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子・活性イオウ分子付加体の化学と解析法.2016
- Author(s)
  安孫子ユミ、新開泰弘、熊谷嘉人.
- Organizer
  新学術領域研究｢酸素生物学｣第3回技術支援セミナー
- Place of Presentation
  名古屋大学シンポジオン（愛知県・名古屋市）
- Year and Date
  2016-01-23
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] フェーズゼロ反応：活性イオウ分子による親電子物質の捕獲.2016
- Author(s)
  熊谷嘉人.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの撹乱.2016
- Author(s)
  熊谷嘉人
- Organizer
  第89回日本薬理学会年会日本薬理学会・日本毒性学会共催シンポジウム
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Capture of reactive sulfur species by methylmercury to form bismethylmercury sulfide: Implication of the disruptionof redox homeostasis.2016
- Author(s)
  Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Sodium tetrasulfide, a reactive sulfur species, protects cells from 1,4-naphthoquinone induced cytotoxicity through sulfur adduct formation.2016
- Author(s)
  Unoki T, Shinkai Y, Abiko Y, Hirose R, Kumagai Y.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台国際センター（宮城県、仙台市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 反応性環境物質によるタンパク質の化学修飾とそれに対する生体防御系.2016
- Author(s)
  熊谷嘉人.
- Organizer
  第89回産業衛生学会教育講演
- Place of Presentation
  福島県文化センター（福島県、福島市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀による活性イオウ分子の捕獲.2016
- Author(s)
  安孫子ユミ、吉田映子、熊谷嘉人.
- Organizer
  第15回分子予防環境医学研究会大会
- Place of Presentation
  自治医科大学（栃木県・下野市）
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] An atmospheric electrophile activates heat shock factor 1 through S-arylation of heat shock protein 90.2016
- Author(s)
  Hirose R, Unoki T, Abiko Y, Shinkai Y, Sha R, Kumagai Y.
- Organizer
  The 52nd European Congress of the European Societies of Toxicology
- Place of Presentation
  FEBES, Conference and Exhibition Centre (Seville, Spain)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] アセトアミノフェンの新規イオウ付加体の同定.2016
- Author(s)
  安孫子ユミ、石井功、鎌田祥太郎、土屋幸弘、渡邊泰男、居原秀、赤池孝章、熊谷嘉人.
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス（東京都、品川区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Role of Reactive Sulfur Species in Detoxification of Methylmercury: Phase Zero Reaction for Electrophile Trapping and Detoxification.2016
- Author(s)
  Kumagai Y
- Organizer
  Society of Toxicology 55th Annual Meeting Society of Toxicology and Japanese Society of Toxicology Mini-Symposium
- Place of Presentation
  New Orleans（アメリカ）
- Year and Date
  2016-03-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴うレドックスホメオスタシスの破綻.2016
- Author(s)
  熊谷嘉人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（愛知県、名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] The phase-zero reaction: caputure of electrophiles by reactive sulfur species.2016
- Author(s)
  Kumagai Y.
- Organizer
  The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide. Satellite Symposium on Chemical Biology of Reactive Persulfide
- Place of Presentation
  東北大学医学部（宮城県、仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子Na2S4はイオウ付加体形成を通じて1,4-NQによる細胞毒性を軽減する.2015
- Author(s)
  鵜木隆光、新開泰弘、熊谷嘉人.
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス.2015
- Author(s)
  井田智章、居原　秀、澤　智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] 親電子物質のケミカルバイオロジー：化学修飾を介したレドックスシグナル伝達および毒性発現とそれらを制御する活性イオウ分子.2015
- Author(s)
  熊谷嘉人
- Organizer
  持田製薬株式会社創薬研究所セミナー
- Place of Presentation
  持田製薬創薬研究所（静岡県・御殿場市）
- Year and Date
  2015-10-14
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive sulfur species and reactive oxygen species-mediated reversible activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone.2015
- Author(s)
  Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju（韓国）
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 有機水銀の神経毒性発現における8-ニトロ-cGMPの役割と活性イオウ分子による制御.2015
- Author(s)
  藤井重元、笠松真吾、居原秀、津々木博康、石崎健勝、井田智章、澤智裕、熊谷嘉人、赤池孝章.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀曝露による健康リスクに対する活性イオウ分子の役割.2015
- Author(s)
  秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
- Organizer
  フォーラム2015：衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子による修飾.2015
- Author(s)
  新開泰弘、鵜木隆光、鍜冶利幸、熊谷嘉人.
- Organizer
  第10回メタルバイオサイエンス研究会
- Place of Presentation
  名古屋国際センターホール（愛知県・名古屋市）
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] カドミウムの防御応答に関わるHSP/HSF1経路の活性化と活性イオウ分子によるその制御.2015
- Author(s)
  増田章、新開泰弘、熊谷嘉人.
- Organizer
  フォーラム2015：衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質のレドックスシグナル伝達変動とそれを制御する活性イオウ分子2015
- Author(s)
  熊谷嘉人
- Organizer
  生理学研究所生体情報研究系心循環シグナル研究部門公開セミナー
- Place of Presentation
  自然科学研究機構岡崎統合バイオサイエンスセンター（愛知県・岡崎市）
- Year and Date
  2015-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Chemical Biology of Electrophiles.2015
- Author(s)
  Kumagai Y
- Organizer
  CEPID-Redoxoma seminar in University of Sao Paulo
- Place of Presentation
  Sao Paulo（ブラジル）
- Year and Date
  2015-11-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Methylmercury glutathione adduct activates Nrf2 through S-transmercuration to Keap1 in SH-SY5Y cells.2015
- Author(s)
  Abiko Y, Yoshida E, Kumagai Y.
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju（韓国）
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質によるタンパク質の化学修飾を介したシグナル伝達活性化.2015
- Author(s)
  熊谷嘉人
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Glutathione adduct of methylmercury activates Nrf2 through covalent modification of Keap1in SH-SY5Y Cells.2015
- Author(s)
  Kumagai Y, Abiko Y, Yoshida E.
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies.
- Place of Presentation
  Honolulu（アメリカ）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質ポリサルファ化の分子メカニズムの解明.2015
- Author(s)
  井田智章、居原秀、魏范研、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章.
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] メチル水銀による活性イオウ分子の捕獲とそれに伴う生体内レドックスホメオスタシスの変動.2015
- Author(s)
  安孫子ユミ、吉田映子、熊谷嘉人.
- Organizer
  第10回メタルバイオサイエンス研究会
- Place of Presentation
  名古屋国際センターホール（愛知県・名古屋市）
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質poly-S-グアニル化を介した親電子シグナルの可逆的制御.2015
- Author(s)
  赤司壮一郎、笠松真吾、ジョンミンギョン、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、本橋ほづみ、赤池孝章.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質poly-S-グアニル化を介した親電子シグナルの可逆的制御.2015
- Author(s)
  赤司壮一郎、笠松真吾、ジョンミンギョン、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、本橋ほづみ、赤池孝章.
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion．2015
- Author(s)
  石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠．
- Organizer
  第16回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  日本薬学会長井記念ホール（東京都・渋谷区）
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Biotin-(PEAC)5-maleimide-ELISAを用いた親電子性キノン化合物によるタンパク質修飾の簡便アッセイの提案.2015
- Author(s)
  安孫子ユミ、Nho Cong Luong、熊谷嘉人.
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子と酸化ストレスが介在する1,2-ナフトキノンによる可逆的なKeap1-Nrf2経路の活性化．2015
- Author(s)
  新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人．
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質の不活性化に関与する活性イオウ分子：フェーズゼロ反応の提案.2015
- Author(s)
  熊谷嘉人:
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質S－ポリチオール化による親電子シグナル制御.2015
- Author(s)
  赤司壮一郎、笠松真吾、Jung Minkyung、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤　智裕、熊谷嘉人、赤池孝章.
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] システイン・活性イオウ分子産生酵素CSEのアセトアミノフェン肝障害における保護的役割.2015
- Author(s)
  石井功、安孫子ユミ、鎌田祥太郎、熊谷嘉人.
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス.2015
- Author(s)
  井田智章、居原　秀、澤　智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 生体内でのメチル水銀解毒代謝におけるCSEの役割.2015
- Author(s)
  秋山雅博、外山喬士、吉田映子、鵜木隆光、安孫子ユミ、新開泰弘、熊谷嘉人.
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他（石川県・金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] A431細胞における9,10- フェナントラキノン曝露により生じる活性酸素種によるEGFR/ERK シグナルの活性化.2015
- Author(s)
  Luong Cong Nho、安孫子ユミ、熊谷嘉人.
- Organizer
  フォーラム2015：衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] 親電子性キノン化合物によるタンパク質修飾のBiotin-(PEAC)5-maleimide-ELISA を用いた検出.2015
- Author(s)
  安孫子ユミ、Luong Cong Nho、熊谷嘉人.
- Organizer
  フォーラム2015：衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Contribution of the Keap1-Nrf2 pathway and CBS/CSE to produce reactive sulfur species to protection against methylmercury.2015
- Author(s)
  Kumagai Y
- Organizer
  The 9th Congress of Toxicology in Developing Countries
- Place of Presentation
  Natal（ブラジル）
- Year and Date
  2015-11-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 有機水銀の神経毒性発現における8-ニトロ-cGMPの役割と活性イオウ分子による制御.2015
- Author(s)
  藤井重元、笠松真吾、居原秀、津々木博康、石崎健勝、井田智章、澤智裕、熊谷嘉人、赤池孝章.
- Organizer
  第88回日本生化学会大会、2015年　12/3
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] タンパク質S－ポリチオール化による親電子シグナル制御.2015
- Author(s)
  赤司壮一郎、笠松真吾、Jung Minkyung、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤　智裕、熊谷嘉人、赤池孝章.
- Organizer
  第68回日本酸化ストレス学会学術集会
- Place of Presentation
  かごしま県民交流センター（鹿児島県・鹿児島市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質ポリサルファ化の分子メカニズムの解明.2015
- Author(s)
  井田智章、居原秀、魏范研、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Dynamin-related protein 1の酸化修飾による病的心臓リモデリング制御2015
- Author(s)
  西田基宏、西村明幸、永井直杜、外山喬士、冨田（沼賀）拓郎、熊谷嘉人、赤池孝章
- Organizer
  第15回日本ＮＯ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府・豊中市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Activation of the Keap1/Nrf2 pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L.2015
- Author(s)
  Kumagai Y
- Organizer
  The 7th International Congress of Asian Society of Toxicology
- Place of Presentation
  Jeju（韓国）
- Year and Date
  2015-06-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Chemical Biology of Electrophiles.2015
- Author(s)
  Kumagai Y
- Organizer
  CEPID-Redoxoma seminar in University of Sao Paulo
- Place of Presentation
  サンパウロ（ブラジル）
- Year and Date
  2015-11-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01392
[Presentation] 心虚血再灌流障害におけるホモシステインの新規作用機序.2015
- Author(s)
  石井功、中埜信太郎、新村健、玉城香代子、菱木貴子、赤星軌征、井田智章、中西豪、鎌田祥太郎、熊谷嘉人、赤池孝章、福田恵一、佐野元昭、末松誠.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Environmental electrophiles-mediated modulation of redox signal transduction pathways and toxicity regulated by reactive sulfur species.2015
- Author(s)
  Kumagai Y
- Organizer
  2015 International Conference on Industrial Hygiene and Occupational Medicine
- Place of Presentation
  高雄（台湾）
- Year and Date
  2015-04-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Ambient Vaper Samples Acrivate the Nrf2-ARE Pathway but Not an Inflammatory Response in Human Bronchial Epithelial BEAS-2B Cells.2014
- Author(s)
  Shinkai Y, Nakajima S, Eiguren-Fernandez A, Stefano ED, Schmitz DA, Froines JR, Cho AK, Kumagai Y.
- Organizer
  Society of Toxicology 53th Annual Meeting
- Place of Presentation
  Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Identification of phytochemicals from Coriandrum sativum L. leaf extract to activate Nrf2 through electrophilic modification of the 2-alkenal group.2014
- Author(s)
  Abiko Y, Mizokawa M, Kumagai Y.
- Organizer
  The Environmental Response IV
- Place of Presentation
  東北大学さくらホール（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Proteomics Analysis to Identify Sensor Proteins with Covalent Modification Associated with 1,4-Naphthoquinone-Induced Activation of Electrophilic Signal Transduction Pathways.2014
- Author(s)
  Hirose R, Miura T, Sha R, Shinkai Y, Tanaka-Kagawa T, Kumagai Y.
- Organizer
  Society of Toxicology 53th Annual Meeting
- Place of Presentation
  Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 芳香族炭化水素キノン類による芳香族炭化水素受容体の活性化.2014
- Author(s)
  安孫子ユミ、Puga Alvaro、熊谷嘉人
- Organizer
  第13回分子予防環境医学研究会
- Place of Presentation
  和歌山県民文化会館（和歌山県和歌山市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Cooperative role of the Keap1-Nrf2 pathway and CBS/CSE in methyl mercury toxicity.2014
- Author(s)
  Kumagai Y.
- Organizer
  The Environmental Response IV
- Place of Presentation
  東北大学さくらホール（宮城県仙台市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Regulation of Covalent Modification of 2-Tert-Butyl-1,4-Benzoquinone to Keap1 through Glutathione-Mediated S-Transarylation.2014
- Author(s)
  Abiko Y, Kumagai Y.
- Organizer
  Society of Toxicology 53th Annual Meeting
- Place of Presentation
  Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Role of Reactive Sulfur Species in Reduction of Methylmercury Toxicity In Vitro and In Vivo.2014
- Author(s)
  Yoshida E, Toyama T, Kumagai Y.
- Organizer
  Society of Toxicology 53th Annual Meeting
- Place of Presentation
  Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性硫黄種によるレドックス恒常性維持機構に基づいた新規心不全治療戦略の構築.2014
- Author(s)
  西田基宏、外山喬士、熊谷嘉人、冨田拓郎
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質のケミカルバイオロジー：化学修飾を介したシグナル伝達の変動および毒性発現とそれらを制御する活性イオウ分子.2014
- Author(s)
  熊谷嘉人
- Organizer
  東北薬科大学創薬研究センターシンポジウム
- Place of Presentation
  東北薬科大学（宮城県・仙台市）
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質のケミカルバイオロジー.2014
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会九州支部特別講演会
- Place of Presentation
  第一薬科大学（福岡県・福岡市）
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Activation of Nrf1/ARE pathway by cadmium in vascular endothelial cells.2014
- Author(s)
  Shinkai Y, Kaji T, Kumagai Y.
- Organizer
  The Environmental Response IV
- Place of Presentation
  東北大学さくらホール（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 親電子物質の反応性を制御する活性イオウ分子：フェーズゼロ反応の提案.2014
- Author(s)
  熊谷嘉人
- Organizer
  レドックスシンポジウム：酸素生物学の誕生
- Place of Presentation
  名古屋大学ES総合館ESホール（愛知県・名古屋市）
- Year and Date
  2014-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Activation of Nrf1/ARE pathway by cadmium in vascular endothelial cells2014
- Author(s)
  Yasuhiro Shinkai, Toshiyuki Kaji, Yoshito Kumagai
- Organizer
  The Environmental Response
- Place of Presentation
  東北大学片平さくらホール（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] メチル水銀とそのグルタチオン抱合体によるKeap1/Nrf2 経路の活性化2013
- Author(s)
  新開泰弘、吉田映子、外山喬士、熊谷嘉人
- Organizer
  環境省メチル水銀研究ミーティング
- Place of Presentation
  ＬＭＪ東京研修センター（東京都文京区）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Role of the keap1/Nrf2 pathway in methylmercury-mediated neurotoxicity.2013
- Author(s)
  Kumagai Y
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  COEX Convention Center（韓国ソウル）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] グルタチオンによるユビキチンC末端加水分解酵素L1の親電子修飾の可逆性.2013
- Author(s)
  外山喬士、矢澤亜季、鍛冶利幸、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] タンパク質の化学修飾を生じる環境中親電子物質のケミカルバイオロジー.2013
- Author(s)
  熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー学術賞受賞講演
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀と活性イオウ分子2013
- Author(s)
  熊谷嘉人
- Organizer
  環境省メチル水銀研究ミーティング
- Place of Presentation
  ＬＭＪ東京研修センター（東京都文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Activation of Heat Shock Response during exposure of human epithelial A431 cells to an environmental electrophile, 1,4-naphthoquinone2013
- Author(s)
  Sha R, Shinkai Y, Kumagai Y.
- Organizer
  第12回分子予防環境医学研究会
- Place of Presentation
  つくば
- Year and Date
  2013-02-02
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] 環境中親電子物質の有害性を制御する活性イオウ分子.2013
- Author(s)
  熊谷嘉人
- Organizer
  第24回日本生体防御学会学術総会
- Place of Presentation
  くまもと森都心プラザ｣プラザホール（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 転写因子Nrf2の活性化能を有するCoriandrum sativum L. 葉抽出物に含有される脂肪族親電子物質の同定.2013
- Author(s)
  溝河真衣、安孫子ユミ、新開泰弘、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] GSH-mediates S-Transarylation regulates covalent modification of Keap1 by tert-butylbenzoquinone.2013
- Author(s)
  Abiko Y, Miura T, Bui H Phuc, Shinkai Y, Kumagai Y.
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  COEX Convention Center（韓国ソウル）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] グルタチオン依存的 S-トランスアリール化反応は Keap1へのtert-ブチルベンゾキノンによる化学修飾を制御する.2013
- Author(s)
  安孫子ユミ、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Coriandrum sativum L.葉抽出物に含有される脂肪族親電子物質による無機三価ヒ素の細胞毒性軽減.2013
- Author(s)
  安孫子ユミ、溝川真衣、熊谷嘉人
- Organizer
  第19回ヒ素シンポジウム
- Place of Presentation
  九州大学コラボステーション
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀の解毒を制御するタンパク質由来活性イオウ分子のプロテオミクス.2013
- Author(s)
  吉田映子、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Removal of 2-tert-butyl-1,4-benzoquinone from Keap1-TBQ adduct by glutathione-mediated S-transarylation.2013
- Author(s)
  Abiko Y, Kumagai Y.
- Organizer
  The 8th Tsukuba Medical Science Research Meeting
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 硫化水素による親電子シグナルと毒性制御.2013
- Author(s)
  熊谷嘉人
- Organizer
  第13回日本NO学会学術集会
- Place of Presentation
  沖縄県医師会館（沖縄県那覇市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Adaptive response and detoxification of the environmental electrophile regulated by the Keap1/Nrf2 pathway.2013
- Author(s)
  Kumagai Y
- Organizer
  International Conference on Nutrition and Physical Activity in Aging, Obesity and Cancer （NAPA2013）
- Place of Presentation
  Centara Grand Mirage Beach Resort（Thailand）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 有機-無機ハイブリッド分子による生体防御系の活性化.2013
- Author(s)
  藤江智也, 中寛史, 立浪忠志, 山本千夏, 廣岡孝志, 安池修之, 新開泰弘,熊谷嘉人, 内山真伸, 鍜冶利幸
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23659063
[Presentation] 1,4ナフトキノンは親電子修飾を介して生存シグナル制御に関わるHSF90/HSF1系を活性化する.2013
- Author(s)
  新開泰弘、沙亮、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] A unique redox signal transduction pathway regulated by reactive sulfur species.2013
- Author(s)
  Kumagai Y
- Organizer
  The 2nd Human Biology Symposium
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子リガンドの毒性を制御するH2S/HS-系.2013
- Author(s)
  新開泰弘、吉田映子、外山喬、石井功、赤池孝章、熊谷嘉人
- Organizer
  第66回日本酸化ストレス学会学術集会
- Place of Presentation
  ウインクあいち（愛知県名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 1,4ナフトキノンは親電子修飾を介して生存シグナル制御に関わるHSF90/HSF1系を活性化する2013
- Author(s)
  新開泰弘、沙亮、熊谷嘉人
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] 血管内皮細胞においてビグリカンの発現制御はシンデカン-4の発現を誘導する.2013
- Author(s)
  原崇人、新開泰弘、山本千夏、熊谷嘉人、鍛冶利幸
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Detoxification of methylmercury by hydrogen sulfide producing enzyme in vitro and in vivo.2013
- Author(s)
  Yoshida E, Toyama T, Kumagai Y.
- Organizer
  The 8th Tsukuba Medical Science Research Meeting
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質によるタンパク質の化学修飾とそれに対する応答戦略2012
- Author(s)
  熊谷嘉人
- Organizer
  第39回日本毒性学会学術年会シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] Negative regulation of CBS to generate hydrogen sulfide on activation of an electrophilic signaling in human epithelial A431 cells.2012
- Author(s)
  Kumagai Y.
- Organizer
  The 33rd Naito Conference on Oxygen, Oxidative Stress and Diseases
- Place of Presentation
  札幌
- Year and Date
  2012-06-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] Invasion of environmental electrophiles into cells, resulting in a modulation of cellular signaltransduction pathways2012
- Author(s)
  Kumagai Y
- Organizer
  UK-Japan Research Symposium. Molecular Mechanisms of Stress Response in Disease
- Place of Presentation
  つくば
- Year and Date
  2012-04-07
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] The Keap1-Nrf2 system regulates metallothionein expression and protects vascular endothelial cells from cadmium cytotoxicity2011
- Author(s)
  Shinkai Y, Kumagai Y, Kimura T, Yamamoto C, Yamamoto M, Jinno H, Tanaka-Kagawa T, Kaji T
- Organizer
  Society of Toxicology 50th Annual Meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化は仁素の毒性の軽減に関与する2011
- Author(s)
  安孫子ユミ、新開泰弘、角大悟、熊谷嘉人
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  旭川市(北海道)
- Year and Date
  2011-01-06
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気親電子物質1, 4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発2011
- Author(s)
  広瀬玲子, 三浦高, 新開泰弘, 香川(田中)聡子, 神野透人, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] タンパク質の親電子修飾の制御に働く新奇求核分子としての硫化水素2011
- Author(s)
  熊谷嘉人
- Organizer
  第11回日本NO学会学術集会
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] 親電子物質によるタンパク質の化学修飾と心毒性2011
- Author(s)
  熊谷嘉人
- Organizer
  八ヶ岳フォーラム
- Place of Presentation
  長野県
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] カドミウムによる親電子物質応答配列を介した転写因子Nrf1の活性化2011
- Author(s)
  伊藤友里, 新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子修飾の自己制御を司る解糖系タンパク質2011
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム.2011
- Author(s)
  熊谷嘉人
- Organizer
  九州大学・生体防御医学研究所共同利用研究集会(招待講演)
- Place of Presentation
  九州大学（福岡県）
- Data Source
  KAKENHI-PROJECT-23659063
[Presentation] メチル水銀によるS-水銀化を介したソルビトール脱水素酵素の機能破綻2011
- Author(s)
  外山喬士, 神田洋紀, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  安全性評価研究会セミナー
- Place of Presentation
  東京都
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気親電子物質1,4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発2011
- Author(s)
  広瀬玲子、三浦高、新開泰弘、香川(田中)聡子、神野透人、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質によるタンパク質の化学修飾と心毒性2011
- Author(s)
  熊谷嘉人
- Organizer
  八ヶ岳フォーラム
- Place of Presentation
  長野県(招待講演)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  第4回エコファーマシンポジウム
- Place of Presentation
  熊本市(熊本県)
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] Mechanisms by which glyceraldehyde-3-phosphate dehydrogenase protects itself against a chemical modification2011
- Author(s)
  Miura T, Egara Y, Hirose R, Iwamoto N, Shinkai Y, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
- Organizer
  Society of Toxicology 50th Annual Meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-03-08
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略.2011
- Author(s)
  熊谷嘉人
- Organizer
  第4回エコファーマシンポジウム
- Place of Presentation
  熊本市(熊本県)
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質の活性制御を担う硫化水素2011
- Author(s)
  熊谷嘉人
- Organizer
  第64回日本酸化ストレス学会学術集会
- Place of Presentation
  北海道(招待講演)
- Year and Date
  2011-07-03
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] Detoxification of an environmental electrophile by hydrogen sulfide : a function as a nucleophilic molecule2011
- Author(s)
  Kumagai Y
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都府(招待講演)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略.2011
- Author(s)
  熊谷嘉人
- Organizer
  安全性評価研究会セミナー(招待講演)
- Place of Presentation
  明治製菓ビル（東京都）
- Data Source
  KAKENHI-PROJECT-23659063
[Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  安全性評価研究会セミナー
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム2011
- Author(s)
  熊谷嘉人
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  旭川市(北海道)
- Year and Date
  2011-01-15
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] グルタチオンの新たな機能:大気中親電子物質による細胞内タンパク質の化学修飾制御に係わるS-トランスアリール化2011
- Author(s)
  三浦高, 掛橋秀直, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
- Author(s)
  熊谷嘉人.
- Organizer
  第4回エコファーマシンポジウム
- Place of Presentation
  熊本
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御2011
- Author(s)
  熊谷嘉人, 外山喬士, 新開泰弘, 角大悟, 山本雅之
- Organizer
  第10回分子予防環境医学研究会
- Place of Presentation
  京都府
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム2011
- Author(s)
  熊谷嘉人
- Organizer
  九州大学・生体防御医学研究所共同利用研究集会
- Place of Presentation
  福岡県
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化はヒ素の毒性の軽減に関与する2011
- Author(s)
  安孫子ユミ, 新開泰弘, 角大悟, 熊谷嘉人
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  北海道
- Year and Date
  2011-02-05
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム.2011
- Author(s)
  熊谷嘉人
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  旭川市
- Year and Date
  2011-01-05
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電子物質:タンパク質の化学修飾を介した有害反応とそれに対する生体側の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  日本自動車研究所講演会
- Place of Presentation
  東京
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム2011
- Author(s)
  熊谷嘉人
- Organizer
  九州大学・生体防御医学研究所共同利用研究集会
- Place of Presentation
  福岡県(招待講演)
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム2011
- Author(s)
  熊谷嘉人
- Organizer
  第16回ヒ素シンポジウム
- Place of Presentation
  北海道
- Year and Date
  2011-02-05
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御2011
- Author(s)
  熊谷嘉人、外山喬士、新開泰弘、角大悟、山本雅之
- Organizer
  分子予防環境医学研究会
- Place of Presentation
  京都市(京都府)
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム2011
- Author(s)
  熊谷嘉人
- Organizer
  九州大学・生体防御医学研究所共同利用研究集会
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-23659063
[Presentation] メチル水銀の解毒防御因子としての硫化水素2011
- Author(s)
  吉田映子、外山喬士、新開泰弘、熊谷嘉人
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  愛知県
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] 哺乳類における硫化水素産生酵素が係わるメチル水銀の新奇解毒代謝物(MeHg)2S2011
- Author(s)
  吉田映子、外山喬士、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] A unique protein mediating cellular protection against methylmercury.2011
- Author(s)
  Kumagai Y
- Organizer
  NIMD Forum
- Place of Presentation
  水俣市(熊本県)
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電子物質:タンパク質の化学修飾を介した有害反応とそれに対する生体側の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  日本自動車研究所講演会
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  第4回エコファーマシンポジウム
- Place of Presentation
  熊本県
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  安全性評価研究会セミナー
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23659063
[Presentation] ブチルヒドロキシアニソールで生じるNrf2活性化はその親電子代謝物によるKeap1の化学修飾が関与する2011
- Author(s)
  安孫子ユミ, 岩本典子, Bui Hoang Phuc, 新開泰弘, 熊谷嘉人
- Organizer
  第38回日本トキシコロジー学会学術集会
- Place of Presentation
  神奈川県
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  第4回エコファーマシンポジウム2011年
- Place of Presentation
  熊本市(熊本県)
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] アクアポリン9はマウス初代肝細胞においてヒ素の細胞内蓄積とそれに伴う細胞毒性に関与する2011
- Author(s)
  新開泰弘, 角大悟, 外山喬士, 熊谷嘉人
- Organizer
  第17回ヒ素シンポジウム
- Place of Presentation
  茨城県
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] ブチルヒトロキシアニソールの親電子代謝物による芳香族炭化水素受容体の活性化2011
- Author(s)
  安孫子ユミ, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  石川県
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  第4回エコファーマシンポジウム
- Place of Presentation
  熊本県(熊本市)
- Year and Date
  2011-02-08
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略2011
- Author(s)
  熊谷嘉人
- Organizer
  安全性評価研究会セミナー
- Place of Presentation
  東京都(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PUBLICLY-23117703
[Presentation] 生体内親電子性代謝物ニトロ化オレイン酸はPTP1Bの活性を阻害しEGFRシグナル伝達経路を活性化する2010
- Author(s)
  岩本典子、Bruce A Freeman、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略2010
- Author(s)
  熊谷嘉人
- Organizer
  北陸大学学術フロンティア・サテライトミーティング
- Place of Presentation
  熊本県
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する2010
- Author(s)
  新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京都
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化2010
- Author(s)
  安孫子ユミ Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
- Author(s)
  矢澤亜季、岩本典子、安孫子ユミ、浅井聡、三浦高、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  仙台市(宮城県)
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割2010
- Author(s)
  新開泰弘、外山喬士、安武章、山本雅之、熊谷嘉人
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  仙台市(宮城県)
- Year and Date
  2010-05-11
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質とその制御に係わる細胞内システム2010
- Author(s)
  熊谷嘉人
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  亀岡市(京都府)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
- Author(s)
  矢澤亜季、岩本典子、安孫子ユミ、浅井聡、三浦高、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] 8-Nitro-cGMPによるGAPDHの基質依存的な酸化的不活性化の促進2010
- Author(s)
  小野勝彦、居原秀、三浦高、岩本典子、澤智裕、熊谷嘉人、赤池孝章
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸市(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 血管内皮細胞においてNrf1はカドミウムに対する防御応答を担う転写因子である2010
- Author(s)
  新開泰弘, 山本千夏, 鍛治利幸, 熊谷嘉人
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄県
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Nrf2-dependent protection against methylmercury toxicity in vitro and in vivo2010
- Author(s)
  Kumagai Y, Toyama T, Shinkai Y, Yasutake
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  Balcelona, Spain
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略2010
- Author(s)
  熊谷嘉人
- Organizer
  北陸大学学術フロンティアー・サテライトミーティング
- Place of Presentation
  水俣
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Activation of EGFR coupled to reduction of PTP1B activity by nitratedoleic acid : an electrophile signaling.2010
- Author(s)
  Iwamoto N, Akaike T, BA Freeman, Kumagai Y
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  京都市(京都府)
- Year and Date
  2010-06-14
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化2010
- Author(s)
  安孫子ユミ, Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京都
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する2010
- Author(s)
  新開泰弘、山本千夏、鍛冶利幸、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 血管内皮細胞においてNrflはカドミウムに対する防御応答を担う転写因子である2010
- Author(s)
  新開泰弘、山本千夏、鍛治利幸、熊谷嘉人
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  宜野湾市(沖縄県)
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Glyceraldehyde 3-phosphate dehydrogenaseの基質依存的な酸化的不活性化2010
- Author(s)
  小野勝彦、居原秀、三浦高、岩本典子、熊谷嘉人、澤智裕、赤池孝章
- Organizer
  第63回日本酸化ストレス学会学術集会
- Place of Presentation
  横浜市(神奈川県)
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  仙台市(宮城県)
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
- Author(s)
  三浦高、岩本典子、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
- Author(s)
  三浦高、岩本典子、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割2010
- Author(s)
  新開泰弘, 外山喬士, 安武章, 山本雅之, 熊谷嘉人
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  宮城県
- Year and Date
  2010-05-11
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定2010
- Author(s)
  矢澤亜季, 岩本典子, 安孫子ユミ, 浅井聡, 三浦高, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京都
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Nrf2-dependent protection' against methylmercury toxicity in vitro and in vivo.2010
- Author(s)
  Kumagai Y, Toyama T, ShinkaiY, Yasutake
- Organizer
  XII International Congress of Toxicology
- Place of Presentation
  バルセロナ(スペイン)
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
- Author(s)
  三浦高, 岩本典子, 新開泰弘, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京都
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質とその制御に係わる細胞内システム2010
- Author(s)
  熊谷嘉人
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  亀岡市(京都府)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾.2010
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  仙台市
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素2010
- Author(s)
  三浦高、岩本典子、新開泰弘、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  品川区(東京都)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質とその制御に係わる細胞内システム2010
- Author(s)
  熊谷嘉人
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  京都府
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾2010
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  宮城県
- Year and Date
  2010-05-09
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾.フォーラム20092009
- Author(s)
  熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジーシンポジウム
- Place of Presentation
  沖縄県
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
- Author(s)
  熊谷嘉人
- Organizer
  大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
- Place of Presentation
  大阪
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] Cellular proteins regulating electrophile signaling2009
- Author(s)
  熊谷嘉人
- Organizer
  FRR International Free Radical School in Japan
- Place of Presentation
  新潟
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合.2009
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会129年会日本薬学会学術振興賞受賞講演
- Place of Presentation
  京都市
- Year and Date
  2009-03-25
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 転写因子Nrf2はメチル水銀のリスク軽減因子である2009
- Author(s)
  外山喬士, 安武章, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄県
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Electrophile-mediated activation of PTP1B/EGFR signaling through post-translational modification of a non-catalytic Cys121 of PTP1B2009
- Author(s)
  Iwamoto N, Ito S, Kobayashi M, Kumagai Y
- Organizer
  International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
- Place of Presentation
  熊本県
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile2009
- Author(s)
  Kumagai Y, Iwamoto N
- Organizer
  The 5th International Congress of Asian Society of Toxicology
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 新電子シグナルの制御機構2009
- Author(s)
  熊谷嘉人
- Organizer
  第62回日本酸化ストレス学会学術集会シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
- Author(s)
  熊谷嘉人
- Organizer
  大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
- Place of Presentation
  大阪府
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
- Author(s)
  熊谷嘉人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫県
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電物質によるレドックスセンサーの翻訳後修飾2009
- Author(s)
  熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] Reduction of arsenic mediated cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells2009
- Author(s)
  Abiko A, Sumi D, Kumagai Y
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京都
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 酸化ストレスを生じる大気中多環芳香族炭化水素2009
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-04-01
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
- Author(s)
  熊谷嘉人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系2009
- Author(s)
  熊谷嘉人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] 新電子シグナルの制御機構2009
- Author(s)
  熊谷嘉人
- Organizer
  第62回日本酸化ストレス学会学術集会シンポジウム
- Place of Presentation
  福岡県
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquinone2009
- Author(s)
  Kumagai Y, Iwamoto N
- Organizer
  International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
- Place of Presentation
  熊本県
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile2009
- Author(s)
  熊谷嘉人
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Protective role of Nrf2 against methylmercury toxicity2009
- Author(s)
  Toyama T, Yasutake A, Kumagai Y
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京都
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾とそれを制御する因子2009
- Author(s)
  熊谷嘉人
- Organizer
  大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
- Place of Presentation
  大阪
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾2009
- Author(s)
  熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PUBLICLY-21117504
[Presentation] 親電子シゲナルの制御機構2009
- Author(s)
  熊谷嘉人
- Organizer
  第62回日本酸化ストレス学会学術集会シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] 1, 2-NQのCys121修飾によるプロテインチロシンホスファターゼ1B(PTP1B)の構造および活性への影響2009
- Author(s)
  岩本典子, 伊藤創平, 角大悟, 熊谷嘉人
- Organizer
  第129年会日本薬学会
- Place of Presentation
  京都府
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquin one2009
- Author(s)
  熊谷嘉人
- Organizer
  International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
- Place of Presentation
  熊本
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合2009
- Author(s)
  熊谷嘉人
- Organizer
  日本薬学会129年会日本薬学会学術振興賞受賞講演
- Place of Presentation
  京都府
- Year and Date
  2009-03-25
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中揮発相成分はPTP1Bの酸化及び化学修飾を介してEGFR/ERKシグナルを活性化する2009
- Author(s)
  岩本典子, 中嶋瞬, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄県
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 1, 2-Naphthoquinone disrupts CREB transcriptional activity through modification of Cys2862009
- Author(s)
  Endo A, Sumi D, Kumagai Y
- Organizer
  Society of Toxicology's 48th Annual Meeting
- Place of Presentation
  Baltimore, USA
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Atmospheric electrophiles causing oxidative stress and protein modification. JSPS Asia and Africa Platform Program International Seminar2009
- Author(s)
  Kumagai Y
- Organizer
  Environment and Health
- Place of Presentation
  石川県
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 転写因子Nrf2によるメチル水銀の毒性軽減.2009
- Author(s)
  外山喬士, 安武章, 熊谷嘉人
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京都
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile2009
- Author(s)
  熊谷嘉人
- Organizer
  The 5th International Congress of Asian Society of Toxicology
- Place of Presentation
  台湾
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] HepG2細胞における転写因子Nrf2を介したHO-1によるヒ素の毒性軽減2009
- Author(s)
  安孫子ユミ, 角大悟, 熊谷嘉人
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京都
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Atmospheric electrophiles causing oxidative stress and protein modification2009
- Author(s)
  熊谷嘉人
- Organizer
  JSPS Asia and Africa Platform Program International Seminar"Environment and Health"
- Place of Presentation
  金沢
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による非触媒性Cys121の翻訳後修飾を介したPTP1B/EGFRシグナルの活性化2009
- Author(s)
  岩本典子, 伊藤創平, 小林麻己人, 熊谷嘉人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫県
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Cellular proteins regulating electrophile signaling2009
- Author(s)
  熊谷嘉人
- Organizer
  SERR International Free Radical School in Japan
- Place of Presentation
  新潟
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-21659154
[Presentation] Nrf2/Keap1システムを介したヒ素に対する細胞応答・毒性防御戦略2009
- Author(s)
  熊谷嘉人
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会
- Place of Presentation
  東京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系.2009
- Author(s)
  熊谷嘉人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Reduction of protein tyrosine phosphatase 1B activity caused by electrophiles is accompanied by a conformational alteration following covalent modification of Cys1212009
- Author(s)
  Iwamoto N, Ito S, Kobayashi M, Kumagai Y
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京都
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Initial response and cellular protection against 1, 2-Naphthoquinone through Nrf2/Keap1 system2009
- Author(s)
  Miura T, Jiang HY, Nishiyama A, Iwamoto N, Sumi D, Yamamoto M, Kumagai Y
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京都
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile2009
- Author(s)
  Kumagai Y
- Organizer
  21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
- Place of Presentation
  東京都
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾2009
- Author(s)
  熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中親電子性物質とレドックスセンサーの共有結合に起因する細胞内シグナル伝達の撹乱2008
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会(シンポジウム)
- Place of Presentation
  熊本
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19406003
[Presentation] タンパク質に共有結合する環境化学物質の生体応答システム2008
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18256005
[Presentation] 環境化学物質によるタンパク質の翻訳後修飾 : 毒性発現機構の解明に向けた修飾タンパク質の検出とその構造解析2008
- Author(s)
  石井剛志、岩本典子、熊谷嘉人
- Organizer
  第78回日本衛生学会総会
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] 1, 2-ナフトキノンはCys286を介して転写因子CREBに共有結合しその機能を阻害する2008
- Author(s)
  遠藤亜希子, 角大悟, 岩本典子, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本県
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 大気中に含まれる未知の親電子性物質とそれに対する生体応答を評価するシステムの構築2008
- Author(s)
  西山彰、岩本典子、外山喬士、角大悟、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] タンパク質に共有結合する環境化学物質の生体応答システム2008
- Author(s)
  熊谷嘉人
- Organizer
  日本衛生学会総会(シンポジウム)
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19406003
[Presentation] タンパク質に共有結合する環境化学物質の生体応答システム2008
- Author(s)
  熊谷嘉人
- Organizer
  第78回日本衛生学会総会シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18256005
[Presentation] 1, 2-ナフトキノンによるプロテインチロシンホスファターゼ1Bの活性阻害におけるCys121の役割2008
- Author(s)
  岩本典子, 角大悟, 熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本県
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] カドミウムの毒性防御の細胞応答システムを担う転写因子Nrf22008
- Author(s)
  新開泰弘, 山本千夏, 熊谷嘉人, 山本雅之, 鍛冶利幸
- Organizer
  第35回日本トキシコロジー学会学術年会
- Place of Presentation
  東京都
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] メチル水銀の分子標的と細胞応答システム.2008
- Author(s)
  熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  熊本市
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-20241015
[Presentation] 酸化ストレスを生じる1, 2-ナフトキノンの分子標的としてのチオレドキシン2007
- Author(s)
  岩本典子、角大悟、石井剛志、内田浩二、中村肇、淀井淳司、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Year and Date
  2007-11-01
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] 大気中微小粒子成分によるERK1/2シグナル伝達経路の活性化2007
- Author(s)
  岩本典子、張璧伊、角大悟、熊谷嘉人
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] 1, 2-ナフトキノンの解毒に関わるNrf2/Keap1システムの役割2007
- Author(s)
  姜海燕、角大悟、田口恵子、Kit I. Tong、山本雅之、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  大阪
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] Sticky pollutants: chemical knockdown of redox sensors.2007
- Author(s)
  Kumagai Y, et. al.
- Organizer
  The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
- Place of Presentation
  つくば(つくば国際会議場)
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-18659167
[Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化.2007
- Author(s)
  熊谷嘉人, 他
- Organizer
  第7回分子予防環境医学研究会
- Place of Presentation
  北九州
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] 芳香族炭化水素キノン体によるPTP1Bの化学修飾とそれに伴うEGFRのリン酸化.2007
- Author(s)
  熊谷嘉人, 他
- Organizer
  北陸大学学術フロンティア・サテライトミーティング
- Place of Presentation
  岐阜(ぎふ長良川ホテルパーク)
- Year and Date
  2007-07-27
- Data Source
  KAKENHI-PROJECT-18659167
[Presentation] 芳香族炭化水素キノン体によるPTF1Bの化学修飾とそれに伴うEGFRのリン酸化.2007
- Author(s)
  熊谷嘉人, 他
- Organizer
  北陸大学学術フロンティア・サテライトミーティング
- Place of Presentation
  岐阜
- Year and Date
  2007-07-27
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化.2007
- Author(s)
  熊谷嘉人, 他
- Organizer
  第7回分子予防環境医学研究会
- Place of Presentation
  北九州(西日本総合展示場)
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-18659167
[Presentation] 大気中親電子性物質によるPTP1B修飾に伴うEGFRリン酸化2007
- Author(s)
  熊谷嘉人、岩本典子、角大悟
- Organizer
  第7回分子予防環境医学研究会
- Place of Presentation
  福岡
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] Sticky pollutants: chemical knockdown of redox sensors.2007
- Author(s)
  Kumagai Y, et. al.
- Organizer
  The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
- Place of Presentation
  つくば
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] Sticky pollutants: chemical knockdown of redox sensors2007
- Author(s)
  Y. Kumagai
- Organizer
  The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium
- Place of Presentation
  Tsukuba, Japan
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19406003
[Presentation] 大気汚染物質のケミカルバイオロジー(その4) : ナフタレンの活性代謝物1, 2-ナフトキノンと共有結合する細胞内タンパク質を検出する免疫化学的方法2006
- Author(s)
  三浦高、岩本典子、新開泰弘、角大悟、早川和一、熊谷嘉人
- Organizer
  衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Year and Date
  2006-10-30
- Data Source
  KAKENHI-PROJECT-18406003
[Presentation] Role of reactive sulfur species in detoxification of methylmercury: Phase zero reaction for electrophile trapping and detoxification.
- Author(s)
  Kumagai Y, Yoshida E, Shinkai Y, Fukuto JM, Akaike T.
- Organizer
  8th International Nitric Oxide Conference & 6th International Nitrite/Nitrate Conference
- Place of Presentation
  Cleveland, USA
- Year and Date
  2014-06-16 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Bismethylmercury sulfideアッセイを用いた活性イオウ分子を分子内に有するタンパク質の同定.
- Author(s)
  熊谷嘉人、吉田映子、新開泰弘、石井功、赤池孝章.
- Organizer
  第14回日本NO学会学術集会
- Place of Presentation
  ホテルニューオータニ佐賀（佐賀県・佐賀市）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 環境中親電子物質によるタンパク質の化学修飾とそれに対する応答戦略.
- Author(s)
  熊谷嘉人
- Organizer
  第39回日本毒性学会学術年会シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.
- Author(s)
  Shinkai Y, Miura T, Kakehashi H, Akaike T, Kumagai Y.
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  San Diego, United States
- Year and Date
  2015-03-21 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by Generation and Action of Reactive.
- Author(s)
  Kumagai Y.
- Organizer
  Society for Free Radical Biology and Medicine's 21st Annual Meeting
- Place of Presentation
  Seattle, United States
- Year and Date
  2014-11-19 – 2014-11-23
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 転写因子Nrf2の活性化を生じるCoriandrum sativum L.葉抽出物に含有される脂肪族親電子物質の実態解明.
- Author(s)
  安孫子ユミ、溝河真衣、熊谷嘉人.
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Sulfur adducts formation during interaction of nitro-oleic acid with polysulfides.
- Author(s)
  Kumagai Y, Shinkai Y, Schopfer F. J., Akaike T, Freeman B. A.
- Organizer
  The 2015 Nitric Oxide Gordon Research Conference
- Place of Presentation
  Ventura, United States
- Year and Date
  2015-02-15 – 2015-02-20
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子と酸化ストレスを介した 1,2-ナフトキノンによる親電子シグナルの活性化
- Author(s)
  新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] Activation of PTP1B/EGFR signal transduction pathway mediated by environmental electrophiles.
- Author(s)
  Kumagai Y
- Organizer
  2014 Spring Annual Convention of Pharmaceutical Society of Korea
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-04-17 – 2014-04-18
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Invasion of environmental electrophiles into cells, resulting in a modulation of cellular signal transduction pathways. U
- Author(s)
  Kumagai Y
- Organizer
  K-Japan Research Symposium. Molecular Mechanisms of Stress Response in Disease
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PROJECT-22406004
[Presentation] Suppression of arsenite-induced cytotoxicity and activation of Nrf2 by aliphatic electrophiles from Coriandrum sativum L. leaf extract in HepG2 cells.
- Author(s)
  Abiko Y, Mizokawa M, Kumagai Y.
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  San Diego, United States
- Year and Date
  2015-03-21 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress
- Author(s)
  Yasuhiro Shinkai, Takashi Miura, Hidenao Kakehashi, Takaaki Akaike, Yoshito Kumagai
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  San Diego Convention Center（San Diego, USA)
- Year and Date
  2015-03-22 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] 環境中親電子物質の化学修飾を介したレドックスシグナル伝達変動とそれを制御する活性イオウ分子.
- Author(s)
  熊谷嘉人
- Organizer
  第14回分子予防環境医学研究会大会
- Place of Presentation
  大阪市立大学（大阪府・大阪市）
- Year and Date
  2015-02-13 – 2015-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Corianderum sativum L.葉抽出液に含有される脂肪族親電子物質によるシグナル伝達の変動その1：Keap1/Nrf2 システムの活性化と脂肪族親電子物質の同定.
- Author(s)
  安孫子ユミ、溝河真衣、里見綾香、熊谷嘉人.
- Organizer
  第14回分子予防環境医学研究会大会
- Place of Presentation
  大阪市立大学（大阪府・大阪市）
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 8-ニトロ-cGMPによる新規タンパク質翻訳後修飾poly-S-グアニル化の検出法の確立．
- Author(s)
  赤司壮一郎、Jung Minkyung、松永哲郎、井田智章、藤井重元、澤智裕、熊谷嘉人、赤池孝章.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] Corianderum sativum L.葉抽出液に含有される脂肪族親電子物質によるシグナル伝達の変動その2：ヒ素の細胞毒性軽減と炎症シグナル抑制作用.
- Author(s)
  里見綾香、安孫子ユミ、溝河真衣、熊谷嘉人.
- Organizer
  第14回分子予防環境医学研究会大会
- Place of Presentation
  大阪市立大学（大阪府・大阪市）
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子と活性酸素種が介在する可逆的な親電子シグナルの活性化
- Author(s)
  新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する．
- Author(s)
  井田智章、澤智裕、居原秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松誠、本橋ほづみ、藤井重元、松永哲郎、山本雅之、Xian Ming、Fukuto Jon、赤池孝章.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] HepG2細胞における Coriandrum sativum L. 葉抽出液中の脂肪族親電子物質による無機三価ヒ素細胞毒性の軽減.
- Author(s)
  安孫子ユミ、溝川真衣、熊谷嘉人.
- Organizer
  フォーラム2014　衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子と活性酸素種が介在する可逆的な親電子シグナルの活性化.
- Author(s)
  新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀による心臓リスク増大の分子メカニズム.
- Author(s)
  外山喬士、熊谷嘉人、鍜冶利幸、赤池孝章、西田基宏.
- Organizer
  フォーラム2014　衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 活性イオウ分子と酸化ストレスを介した 1,2-ナフトキノンによる親電子シグナルの活性化．
- Author(s)
  新開泰弘、三浦高、掛橋秀直、赤池孝章、熊谷嘉人.
- Organizer
  フォーラム2014　衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] メチル水銀とそのグルタチオン抱合体によるKeap1/Nrf2 経路の活性化
- Author(s)
  新開泰弘、吉田映子、外山喬士、熊谷嘉人
- Organizer
  平成25年度メチル水銀研究ミーティング
- Place of Presentation
  LMJ東京研修センター（東京都文京区）
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] メチル水銀によるタンパク質のS-水銀化を制御する活性イオウ分子.
- Author(s)
  熊谷嘉人
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25220103
[Presentation] 第41回日本毒性学会学術年会
- Author(s)
  新開泰弘、吉田映子、Bruce A. FREEMAN、西田基宏、澤智裕、赤池孝章、熊谷嘉人
- Organizer
  神戸コンベンションセンター
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24590159
[Presentation] 活性イオウ分子産生酵素シスタチオニンβシンターゼによる親電子シグナル伝達系の制御.
- Author(s)
  新開泰弘、吉田映子、Bruce A. FREEMAN、西田基宏、澤智裕、赤池孝章、熊谷嘉人.
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25220103

1. TAKANO Hirohisa (60281698)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. SHINKAI Yasuhiro (10454240)

# of Collaborated Projects: 6 results

# of Collaborated Products: 123 results
3. SHIMOJO Nobuhiro (00080622)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. SUMI Daigo (30400683)

# of Collaborated Projects: 5 results

# of Collaborated Products: 50 results
5. YAMAUCHI Hiroshi (90081661)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
6. ISHII Tetsuro (20111370)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
7. YAMANO Shigeru (80140755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
8. YOSHIDA Takahiko (90200998)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. KAWAKAMI Yasushi (70234028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAGATA Kyosuke (40180492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. AKAIKE Takaaki (20231798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 47 results
12. WARABI Eiji (70396612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. HAYASHI Toshio (80303634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 宮内卓 (60222329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
15. 西田基宏 (90342641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
16. 相川浩幸 (40102850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 石井祐次 (90253468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 伊藤昭博 (40391859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 57 results
19. WAGATSUMA Yukiko (40400676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NOGUCHI Emiko (40344882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OKADA Masafumi (70375492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HAYASHI Taiichi (10111981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TERAO Toru (30303910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ARINAMI Tadao (10212648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KANAHO Yasunori (00214437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. OHNEDA Osamu (30311872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KATO Mitsuyasu (20194855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. INOUE Kenichiro (20373219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. SAWA Tomohiro (30284756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. YOSHITAKE Jun (70414349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. HOMMA Shino (00272203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. IGUCHI Akihisa (20109763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YANAGAWA Toru (10312852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ICHINOSE Takamichi (50124334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
35. AMINAKA Masahito (30231997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. SERA Koichiro (00230855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 嶋本喬 (50143178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 磯博康 (50223053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 石井功 (90292953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
40. 伊東健 (10323289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 上原孝 (00261321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
42. 秋山雅博 (60754570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 58 results
43. 加藤百合 (10732042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
44. SUZUKI Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. Nishimura Akiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
46. WATANABE Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. TAGUCHI Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. TSUCHIYA Yukihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
51. 鵜木隆光

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
52. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
53. 金倫基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
54. 安孫子ユミ

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
55. 船戸洋佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 鈴木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 鍛冶利幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
58. 奥村康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kumagai Yoshito 熊谷 嘉人

KUMAGAI Yosito 熊谷 嘉人

熊谷 嘉人 クマガイ ヨシト

Research Projects

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Co-Researchers

代謝活性化を介した民生品のタンパク質付加体形成によるエピジェネティクス変化Principal Investigator

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環境中親電子物質エクスポソーム研究のモデル化Principal Investigator

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Environmental electrophiles exposome and reactive sulfur species as its regulator moleculePrincipal Investigator

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電子伝達系におけるユビキノンと活性イオウ分子とのレドックスカップルの意義Principal Investigator

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レドックスシグナル伝達の可逆性担保における活性イオウ分子の役割Principal Investigator

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Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur speciesPrincipal Investigator

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Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles

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Activation of cellular signal transduction pathways in protective response to an atmospheric electrophile, 1,4-naphthoquinone

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親電子修飾の制御に働く新奇求核分子としての硫化水素Principal Investigator

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Exploration of a system for cellular response to the electrophilesexhibiting skin sensitization potentialPrincipal Investigator

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Development of an assay to evaluate the reactivity at chemicals contaminated in the atmosphere, South CaliforniaPrincipal Investigator

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活性酸素シグナル伝達を制御するCーS切断酵素Principal Investigator

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Review Section

Research Institution

大気中反応物質により非意図的な化学修飾を受けたタンパク質の生体内運命Principal Investigator

Principal Investigator

Kumagai Yoshito 熊谷嘉人

KUMAGAI Yosito 熊谷嘉人

熊谷嘉人クマガイヨシト