YAMANASHI YUJI 山梨裕司

… Alternative Names

YAMANASHI Yuji 山梨裕司

山梨裕二ヤマナシユウジ

山梨裕司ヤマナシユウジ

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Researcher Number	40202387
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 教授
Affiliation (based on the past Project Information) *help	2008 – 2022: The University of Tokyo, 医科学研究所, 教授 2021: 東京大学, 医科学研究所, 所長 2010: 東京大学, 医科学研究所腫瘍抑制分野, 教授 2001 – 2007: 東京医科歯科大学, 難治疾患研究所, 教授 2000: 東京大学, 医科学研究所, 助教授 … More 1998: 東京大学, 医科学研究所, 助手 1991 – 1994: 東京大学, 医科学研究所, 助手 1991: 東京大学, 医科学研究所・制癌研究部, 助手 1989: 日本学術振興会, 特別研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological Sciences / General medical chemistry / Cell biology / Medium-sized Section 48:Biomedical structure and function and related fields / Complex systems / Medium-sized Section 50:Oncology and related fields / Cell biology / Molecular biology / Pathological medical chemistry … More Except Principal Investigator … More Tumor biology / General medical chemistry / Cell biology / Respiratory organ internal medicine / Neurology / Neurophysiology and muscle physiology Less
Keywords	Principal Investigator シグナル伝達 / チロシンキナーゼ / 細胞・組織 / アダプター / 神経科学 / Dok / 神経筋シナプス / 蛋白質 / トランスジェニックマウス / Src … More / 細胞内シグナル伝達 / 遺伝子 / 神経筋疾患 / 癌 / 造血細胞 / 免疫学 / rasGAP / Dok-2 / Fcγ受容体 / B細胞受容体 / HS1 / 遺伝子欠損マウス / Lyn / 血球系細胞 / lyn / 神経筋シナプス形成シグナル / 運動機能障害 / 腫瘍 / 腫瘍悪性化 / Protein phosphorylation / Adaptor / Organ ＆ Cells / Protein / Signal Transduction / リン酸化 / 組織・細胞 / cell proliferation / immune resonse / adaptor / tyrosine kinase / cellular signaling / 細胞増殖 / 免疫応答 / タンパク質 / 病理学 / 神経変性疾患 / dying-backパソロジー / 発現制御 / 転写制御 / 疾患 / 細胞内情報伝達 / タンパク質チロシンキナーゼ / シグナル会達 / EBウイルス / アダプター分子 / Ras-Erk / 感染症 / ウイルス / チロキシンナーゼ / 白血病 / 増殖異常 / Bcr-Abl / 慢性骨髄性白血病 / FcγRIIB / Fyn / B細胞抗原受容体 / 細胞接着 / トランスフォーメーション / p62 / lgn / SVC / レトロウイルス / レトロウィルス / HTLVーI / チロシンキナ-ゼ … More Except Principal Investigator シグナル伝達 / アポトーシス / 転写因子 / 受容体 / 各プラットフォーム間の連携 / 先進ゲノム解析研究推進 / 先端モデル動物支援 / 先端バイオイメージング支援 / コホート・生体試料支援 / 生命科学連携推進協議会 / Apoptosis / CD40 / Rel / 神経筋接合部 / チロシンキナーゼ / 転写制御 / サイトカイン / 情報伝達 / 各プラットフォーム問の連携 / 先進ゲノム研究推進プラットフォーム / 先端モデル動物支援プラットフォーム / 先端バイオイメージング支援プラットフォーム / コホート・生体試料支援プラットフォーム / 大腸癌 / 浸潤・転移 / 癌 / モデルマウス / 悪性化 / 腸管腫瘍 / 筋無力症 / 神経筋シナプス / 神経筋疾患 / 神経科学 / Cancer / Cell growth / Cell cycle reguration / MAPK / EBウイルス / ゲノム複製 / 細胞周期 / がん / 細胞増殖 / 細胞周期制御 / NFkappaB / B cell differentiation / Transcription factor / Signal transduction / 分子生物学 / 活性酸素 / Re1 / NFkB / B細胞分化 / アダプタータンパク質 / 閉塞性肺疾患 / 疾患モデルマウス / アダプター分子 / 喘息 / DOK-7 / 神筋接合部疾患 / 神経筋接合部疾患 / 重症筋無力症 / Dok-7 / 先天性筋無力症候群 / 遺伝子診断 / 運動神経 / アセチルコリン / 骨格筋 / シナプス / 細胞内情報伝達 / 受容体・細胞内シグナル伝達 / 増殖・分化因子 / カドヘリン / ホスホリパ-ゼC / チロシンキナ-ゼ / SH_2 / 癌遺伝子 / 細胞死 / 増殖,分化因子 / アクチン / リン酸化 / がん遺伝子 / 発がん / 細胞膜裏打ち構造 / 細胞骨格 / 細胞接着 / Adherens Junction Less

生命科学連携推進協議会
- Principal Investigator
  
  TAKEKAWA Mutsuhiro
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
- Research Institution
  The University of Tokyo
Signaling in NMJ formation and therapeutic intervention against neuromuscular disordersPrincipal Investigator
- Principal Investigator
  
  Yamanashi Yuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo
神経筋伝達を担うアセチルコリン受容体の発現制御シグナルの解明Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Molecular mechanisms underlying microenvironment-regulated tumor malignant progressionPrincipal Investigator
- Principal Investigator
  
  Yamanashi Yuji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  The University of Tokyo
Signaling in NMJ formation and its synaptopathyPrincipal Investigator
- Principal Investigator
  
  Yamanashi Yuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Committee on Promoting Collaboration in Life SciencesPrincipal Investigator(Support)
- Principal Investigator
  
  INOUE Jun-ichiro, IMAI Kohzoh
- Principal Investigator(Support)
  
  IMAI Kohzoh, KOHARA Yuji, KANO Masanobu, IMOTO Keiji, YAMAMOTO Masayuki, MURAKAMI Yoshinori, NABEKURA Junichi, AGATA Kiyokazu, YAMANASHI Yuji, UENO Naoto, TAKEKAWA Mutsuhiro, NAKAMURA Takuro, TAKADA Masahiko, TANAKA Hideo, WAKAI Kenji, MURAYAMA Shigeo, KATO Kazuto
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
- Research Institution
  The University of Tokyo
Studies on Metastasis of Colon Cancer Using Mouse Models
- Principal Investigator
  
  Arimura Sumimasa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
NMJを起点とするdying-backパソロジーの解明Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
翻訳後修飾によるLrp4シグナル制御機構とその破綻Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular mechanisms of the formation and maintenance of NMJs
- Principal Investigator
  
  TEZUKA Tohru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
アダプター分子の翻訳後修飾とその異常による疾患の解明Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular signaling in neuromuscular synaptogenesis and myastheniaPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
The role of Dok adaptors in pulmonary disorders
- Principal Investigator
  
  MASHIMA Ryuichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
  Akita University
  The University of Tokyo
Transcriptional regulation in multinucleated cellsPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
NMJ形成不全型の先天性筋無力症候群に対する治療法の開発Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Molecular signaling in neuromuscular synaptogenesis, hematopoiesis, and related disordersPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
Genetic analysis and research on treatment of congenital myasthenic syndromes with Dok-7 mutations (Dok-7 CMS) in Japan.
- Principal Investigator
  
  FUKUDA Taku
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagasaki University
Molecular mechanisms of the neuromuscular synapse formation
- Principal Investigator
  
  OSAMU Higuchi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  The University of Tokyo
  Tokyo Medical and Dental University
Protein kinase signaling and malignant cell proliferationPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Tokyo Medical and Dental University
Dok-mediated regulation of cellular functionsPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University
Signal transduction in cell division
- Principal Investigator
  
  SHIRAKATA Masaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University
蛋白質チロシンリン酸化と癌細胞の増殖応答Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Bcr-Abl下流のrasGAP結合蛋白質Dok及びDok-2と慢性骨髄性白血病Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
免疫細胞シグナルによるEpstein-Barrウイルスの抑制機構の研究Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Functional study on Dok family of proteinsPrincipal Investigator
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University
免疫シグナル伝達におけるrasGAP結合蛋白質Dok及びDok-2の機能解析Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Bcr-Abl下流のrasGAP結合蛋白質Dok及びDok-2と慢性骨髄性白血病Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
慢性骨髄性白血病の原因因子Bcr-Ablの標的蛋白質Dokの機能解析Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
B細胞抗原受容体を介する情報伝達とチロシンリン酸化Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
B細胞抗原受容体を介した細胞内情報伝達と免疫寛容の分子機構Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Joint Research on the signal transduction to the nucleus. -from the membrane receptors to the nuclear transcription factors-
- Principal Investigator
  
  INOUE Junichiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
B細胞抗原受容体を介した細胞内情報伝達と免疫寛容の分子機構Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がんの増殖と分化に関連する遺伝子の発現制御
- Principal Investigator
  
  長田重一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka Bioscience Institute
血球系細胞特異時に発現するSrc型チロシンキナ-ゼLynと細胞の癌化Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
がんの増殖と分化に関連する遺伝子の発現制御
- Principal Investigator
  
  長田重一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka Bioscience Institute
細胞増殖・癌化の細胞内情報伝達とイノシト-ルリン脂質代謝
- Principal Investigator
  
  竹縄忠臣
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
血球系細胞特異的に発現するSrc型ケロシンキナ-ゼLynと細胞の癌化Principal Investigator
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Adherens Junction 細胞膜裏打ち細胞骨格
- Principal Investigator
  
  月田承一郎
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

[Book] 先天性筋無力症の分子基盤、生体の科学2011
- Author(s)
  手塚徹、山梨裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-20247024
[Book] 受容体型キナーゼの細胞内からの活性(実験医学)、27巻(6月号)2009
- Author(s)
  井上茜、瀬戸口喜代子、樋口理、山梨裕司
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17014030
[Book] 受容体型キナーゼの細胞内からの活性、実験医学2009
- Author(s)
  井上茜、瀬戸口喜代子、樋口理、山梨裕司
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20247024
[Book] 受容体型キナーゼの細胞内からの活性化2009
- Author(s)
  井上茜、瀬戸口喜代子、樋口理、山梨裕司
- Publisher
  実験医学・6月号
- Data Source
  KAKENHI-PROJECT-19300142
[Book] 神経筋接合部の分子構築2008
- Author(s)
  樋口理、山梨裕司
- Publisher
  Clinical Neuroscience(中外医学社)
- Data Source
  KAKENHI-PROJECT-19300142
[Book] Clinical Neuroscience (26巻9号)2008
- Author(s)
  樋口理、山梨裕司
- Total Pages
  2
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19300142
[Book] Dok-7シグナルと筋無力症、(実験医学)26巻(増刊)2008
- Author(s)
  山梨裕司
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17014030
[Book] 免疫機構とDok-1/2を介した抑制シグナル(Annual Review免疫2007)2006
- Author(s)
  山梨裕司
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17014030
[Book] チロシンキナーゼのシグナル伝達(実験医学)23巻(増刊)2005
- Author(s)
  山梨裕司
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Adeno-associated virus-mediated expression of an inactive CaMKIIβ mutant enhances muscle mass and strength in mice2022
- Author(s)
  Eguchi Takahiro、Yamanashi Yuji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 589 Pages: 192-196
- DOI
  10.1016/j.bbrc.2021.12.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00496, KAKENHI-PROJECT-21K15369
[Journal Article] 特集新組織学シリーズⅡ:骨格筋-今後の研究の発展に向けて Ⅱ.骨格筋組織を支える細胞の役割･応答神経筋接合部(NMJ)の形成･維持メカニズム-NMJを標的とした治療技術の開発を目指して2021
- Author(s)
  江口貴大、山梨裕司
- Journal Title
  
  生体の科学
  
  Volume: 72 Issue: 6 Pages: 527-531
- DOI
  10.11477/mf.2425201435
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2021-12-15
- Data Source
  KAKENHI-PROJECT-20H00496
[Journal Article] Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission2020
- Author(s)
  Eguchi T, Tezuka T, Fukudome T, Watanabe Y, Sagara H, Yamanashi Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 523 Issue: 1 Pages: 214-219
- DOI
  10.1016/j.bbrc.2019.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01532
[Journal Article] DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice2020
- Author(s)
  Ueta R, Sugita S, Minegishi Y, Shimotoyodome A, Ota N, Ogiso N, Eguchi T, Yamanashi Y
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 8 Pages: 101385-101385
- DOI
  10.1016/j.isci.2020.101385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-20H00496, KAKENHI-PROJECT-18K06127
[Journal Article] Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia2020
- Author(s)
  Webster RG, Vanhaesebrouck AE, Maxwell SE, Cossins JA, Liu W, Ueta R, Yamanashi Y, Beeson DMW
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 29 Issue: 14 Pages: 2325-2336
- DOI
  10.1093/hmg/ddaa116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00496
[Journal Article] Roles of collagen XXV and its putative receptors PTP s/d in intramuscular motor innervation and congenital cranial dysinnervation disorder2019
- Author(s)
  Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 13 Pages: 4362-4376
- DOI
  10.1016/j.celrep.2019.11.112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K06435, KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-17K07091, KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-17H04193
[Journal Article] Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology2016
- Author(s)
  Eguchi T, Tezuka T, Miyoshi S, and Yamanashi Y
- Journal Title
  
  Genes to Cells
  
  Volume: 印刷中 Issue: 6 Pages: 670-676
- DOI
  10.1111/gtc.12370
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-25117708, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-14J08885, KAKENHI-PROJECT-16K14575
[Journal Article] Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.2016
- Author(s)
  Waseda M, Arimura S, Shimura E, Nakae S, and Yamanashi Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 478 Issue: 1 Pages: 135-142
- DOI
  10.1016/j.bbrc.2016.07.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05574, KAKENHI-PROJECT-26860761
[Journal Article] DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction2014
- Author(s)
  Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin’ichi Takeda, Yuji Yamanashi
- Journal Title
  
  Science
  
  Volume: 345 Issue: 6203 Pages: 1505-1508
- DOI
  10.1126/science.1250744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-24500472, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-25461318, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26461302, KAKENHI-PROJECT-26860273
[Journal Article] Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.2014
- Author(s)
  Hughan SC, Spring CM, Schoenwaelder SM, Sturgeon S, Alwis I, Yuan Y, McFadyen JD, Westein E, Goddard D, Ono A, Yamanashi Y, Nesbitt WS, and Jackson SP
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 8 Pages: 5051-5060
- DOI
  10.1074/jbc.m113.520148
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25117708
[Journal Article] The MuSK-activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses2014
- Author(s)
  Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, and Yuji Yamanashi
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 111 Issue: 46 Pages: 16556-16561
- DOI
  10.1073/pnas.1408409111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460357
[Journal Article] Critical role of Frizzledl in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.2014
- Author(s)
  Doi R, Endo M, Yamakoshi K, Y amanashi Y, Nishita M, Fukada SI. Minami Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 19 Issue: 4 Pages: 287-296
- DOI
  10.1111/gtc.12132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J01138, KAKENHI-PLANNED-23112007, KAKENHI-PUBLICLY-24112528, KAKENHI-PROJECT-24390080, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460367, KAKENHI-PROJECT-25702044
[Journal Article] Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.2013
- Author(s)
  Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, Yamanashi Y.
- Journal Title
  
  Genes to Cells
  
  Volume: 18 Issue: 1 Pages: 56-65
- DOI
  10.1111/gtc.12016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J08500, KAKENHI-PUBLICLY-23117511, KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-23591115, KAKENHI-PROJECT-23657113, KAKENHI-PROJECT-24659520, KAKENHI-PLANNED-23112007
[Journal Article] A Mutation Causes MuSK Reduced Sensitivity to Agrin and Congenital Myasthenia2013
- Author(s)
  Asma Ben Ammar
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e53826-e53826
- DOI
  10.1371/journal.pone.0053826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-23657113
[Journal Article] Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic differentiation in myotubes.2013
- Author(s)
  Hoshi T, Tezuka T, Yokoyama K, Iemura S-I, Natsume T, and Yamanashi Y
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 23 Pages: 3749-3754
- DOI
  10.1016/j.febslet.2013.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117511, KAKENHI-PROJECT-23249013, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24121705, KAKENHI-PUBLICLY-25110711, KAKENHI-PUBLICLY-25117708, KAKENHI-PROJECT-25460357
[Journal Article] Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.2012
- Author(s)
  Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, and Yamanashi Y.
- Journal Title
  
  Genes Cells
  
  Volume: 18 Pages: 56065-56065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657113
[Journal Article] Activation of Receptor Protein-Tyrosine Kinases from the Cytoplasmic Compartment2012
- Author(s)
  Yamanashi Y, Tezuka T, and Yokoyama K.
- Journal Title
  
  J Biochem
  
  Volume: (n press) Issue: 4 Pages: 353-359
- DOI
  10.1093/jb/mvs013
- NAID
  10031166074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700391, KAKENHI-PROJECT-23249013, KAKENHI-PLANNED-23112007, KAKENHI-PUBLICLY-24121705
[Journal Article] The transcription factor Sp1 plays a crucial role in dok-7 gene expression2011
- Author(s)
  Hamuro J, Hishida Y, Higuchi O, Yamanashi Y
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 408 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117511
[Journal Article] The transcription factor Sp1 plays a crucial role in dok-7 gene expression.2011
- Author(s)
  Hamuro J, Hishida Y, Higuchi O, and Yamanashi Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 408 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657113
[Journal Article] Autoantibodies to Low-Density Lipoprotein Receptor-Related Protein 4 in Myasthenia Gravis2011
- Author(s)
  Osamu Higuchi, Hamuro Johko, Masakatsu Motomura, and Yuji Yamanashi
- Journal Title
  
  Ann. Neurol
  
  Volume: 69 Pages: 418-422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Autoantibodies to Low-density lipoprotein receptor-related protein 4 in myasthenia gravis.2011
- Author(s)
  Osamu H, Hamuro J, Motomura M, Yamanashi Y
- Journal Title
  
  Annals of Neurology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts2011
- Author(s)
  Kawamata J, Inoue A, Miyajima D, Hemmi H, Mashima R, Hayata T, Exura Y, Amagasa T, Yamanashi Y, Noda M
- Journal Title
  
  J.Cell.Physiol.
  
  Volume: 226 Pages: 3087-3093
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117511
[Journal Article] The transcription factor Sp1 plays a crucial role in dok-7 gene expression2011
- Author(s)
  Hamuro J, Hishida Y, Higuchi O, Yamanashi Y
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 408 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia Gravis2011
- Author(s)
  Higuchi O, Hamuro J, Motomura M, Yamanashi Y
- Journal Title
  
  Annals of Neurology
  
  Volume: 69 Pages: 418-422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Dok-1 and Dok-2 deficiency induces osteopenia via regulation of osteoclasts2011
- Author(s)
  Aya Kawamata
- Journal Title
  
  J. Cell. Physiol.
  
  Volume: 226 Issue: 12 Pages: 3087-3093
- DOI
  10.1002/jcp.22909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-23591115, KAKENHI-PROJECT-23659868, KAKENHI-PROJECT-23791628
[Journal Article] The transcription factor Sp1 plays a crucial role in dok-7 gene expression. Biochem. Biophys.2011
- Author(s)
  Hamuro J, Hishida Y, Higuchi O, and Yamanashi Y.
- Journal Title
  
  Res. Commun.
  
  Volume: 408 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657113
[Journal Article] Autoantibodies to Low-density lipoprotein receptor-related protein 4 in myasthenia gravis.2011
- Author(s)
  Osamu H, Hamuro J, Motomura M, Yamanashi Y
- Journal Title
  
  Annals of Neurology
  
  Volume: 69 Pages: 418-422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659075
[Journal Article] The transcription factor Sp1 plays a crucial role in dok-7 gene expression2011
- Author(s)
  Hamuro Johko, Yukihiro Hishida, Osamu Higuchi, and Yuji Yamanashi
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 408 Pages: 293-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.2010
- Author(s)
  Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y
- Journal Title
  
  Laboratory Investigation
  
  Volume: 90 Pages: 1357-1364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive hisitocytic sarcoma2010
- Author(s)
  Ryuichi Mashima, Honda Kazuho, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, and Yuji Yamanashi
- Journal Title
  
  Lab. Investigation
  
  Volume: 90 Pages: 1357-1364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive hisitocytic sarcoma.2010
- Author(s)
  Ryuichi Mashima, Honda Kazuho, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, Yuji Yamanashi.
- Journal Title
  
  Lab.Investigation 90
  
  Pages: 1357-1364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma2010
- Author(s)
  Mashima R., Honda K., Yang Y., Morita Y., Inoue A., Arimura S., Nishina H., Ema H., Nakauchi H., Seed B., Oda H., Yamanashi Y
- Journal Title
  
  Laboratory Investigation
  
  Volume: 90 Pages: 1357-1364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] The roles of Dok family adapters in immunoreceptor signaling2009
- Author(s)
  Mashima R, Hishida Y, Tezuka T, Yamanashi Y
- Journal Title
  
  Immunological Reviews
  
  Volume: 232 Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] The roles of Dok family adapters in immunoreceptor signaling2009
- Author(s)
  Mashima R., Hishida Y., Tezuka T., Yamanashi Y.
- Journal Title
  
  Immunological Reviews 232
  
  Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659075
[Journal Article] The roles of Dok family adaptors in immunoreceptor signaling.2009
- Author(s)
  Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, Yuji Yamanashi.
- Journal Title
  
  Immunological Reviews 232
  
  Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.2009
- Author(s)
  Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi 0, Yamanashi Y.
- Journal Title
  
  Science Signaling 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation2009
- Author(s)
  Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi O, Yamanashi Y
- Journal Title
  
  Sci. Signaling 2
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.2009
- Author(s)
  Akane Inoue, Kiyoko Setoguchi, Yosuke Matsubara, Kumiko Okada, Nozomi Sato, Yoichiro Iwakura, Osamu Higuchi, Yuji Yamanashi.
- Journal Title
  
  Science Signaling 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation2009
- Author(s)
  Akane Inoue, Kiyoko Setoguchi, Yosuke Matsubara, Kumiko Okada, Nozomi Sato, Yoichiro Iwakura, Osamu Higuchi, and Yuji Yamanashi
- Journal Title
  
  Science Signaling
  
  Volume: 2 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] The roles of Dok family adapters in immunoreceptor sigrraling2009
- Author(s)
  Mashima R., Hishida Y., Tezuka T., Yamanashi Y.
- Journal Title
  
  Immunological Reviews
  
  Volume: 232 Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] The roles of Dok family adaptors in immunoreceptor signaling2009
- Author(s)
  Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, and Yuji Yamanashi
- Journal Title
  
  Immunological Reviews
  
  Volume: 232 Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Dok-7/MuSK signaling pathway and congenital myasthenic syndromes2008
- Author(s)
  Yamanashi Y, Higuchi O, Beeson D
- Journal Title
  
  Acta Myol 27
  
  Pages: 25-9
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Mutations causing DOK7 congenital myasthenia ablate functional elements in Dok-7.2008
- Author(s)
  Hamuro J, Higuchi 0, Okada K, Ueno M, Spearman H, Iemura S, Natsume T, Beeson D, Yamanashi Y.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 5518-5524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARg phosphorylation.2008
- Author(s)
  Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, Takehiro Nakamura, Hiroshi Sakaue, Hiroshi Inoue, Wataru Ogawa, Kazutoshi Tobimatsu, Kazuo Takazawa, Mashito Sakai, Yasushi Matsuki, Ryuji Hiramatsu, Tomoharu Yasuda, Mitchell A.Lazar, Yuji Yamanashi, Masato Kasuga.
- Journal Title
  
  Nature Med. 14
  
  Pages: 188-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-72008
- Author(s)
  Johko Hamuro, Osamu Higuchi, Kumiko Okada, Makiko Ueno, Shun-ichiro Iemura, Tohru Natsume, Hayley Spearman, David Beeson, and Yuji Yamanashi
- Journal Title
  
  J. Biol. Chem
  
  Volume: 283 Pages: 5518-5524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7.2008
- Author(s)
  Johko Hamuro, Osamu Higuchi, Kumiko Okada, Makiko Ueno, Shun-ichiro Iemura, Tohru Natsume, Hayley Spearman, David Beeson, Yuji Yamanashi.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 5518-5524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-7/MuSK signaling and a congenital myasthenic syndrome.2008
- Author(s)
  Yuji Yamanashi, Osamu Higuchi, David Beeson.
- Journal Title
  
  Acta Myologica 27
  
  Pages: 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-7/MuSK signaling pathway and congenital myasthenic syndromes2008
- Author(s)
  Yamanashi Y, Higuchi 0, Beeson D
- Journal Title
  
  Acta Myologica 27
  
  Pages: 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Mutations causing DOK7 congenital myasthenia ablate functional elements in Dok-72008
- Author(s)
  Hamuro J, Higuchi O, Okada K, Ueno M, Spearman H, Iemura S, Natsume T, Beeson D, Yamanashi Y.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 5518-24
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Mutations Causing DOK7 Congenital Myasthenia Ablate Functional Motifs in Dok-72008
- Author(s)
  Johko Hamuro, Osamu Higuchi, Kumiko Okada, Makiko Ueno, Shun-ichiro Iemura, Tohru Natsume, Hayley Spearman, David Beeson, Yuji Yamanashi
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 5518-5524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300142
[Journal Article] Dok-7/MuSK signaling and a congenital myasthenic syndrome2008
- Author(s)
  Yuji Yamanashi, Osamu Higuchi, and David Beeson
- Journal Title
  
  Acta Myologica
  
  Volume: 27 Pages: 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247024
[Journal Article] The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.2007
- Author(s)
  Yosuke Matsubara, Ichiro Kawasaki, Seiichi Urushiyama, Tomoharu Yasuda, Masaki Shirakata, Yuichi Iino, Hiroshi Shibuya, Yuji Yamanashi.
- Journal Title
  
  Genes Cells 12
  
  Pages: 407-420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-1 and Dok-2 are negative regulators of T cell receptor signaling.2007
- Author(s)
  Tomoharu Yasuda, Kenji Bundo, Ayako Hino, Kazuho Honda, Akane Inoue, Masaki Shirakata, Mitsujiro Osawa, ToshikiTamura, Hideo Nariuchi, Hideaki Oda, Tadashi Yamamoto, Yuji Yamanashi.
- Journal Title
  
  Int.Immunology 19
  
  Pages: 487-495
- NAID
  10020110607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-1 is a positive regulator of IL-4 signaling and IgE response.2007
- Author(s)
  Akane Inoue, Tomoharu Yasuda, Tadashi Yamamoto, Yuji Yamanashi.
- Journal Title
  
  J.Biochemistry 142
  
  Pages: 257-263
- NAID
  10020097405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Clinical features of the DOK7 neuromuscular junction synaptopathy.2007
- Author(s)
  Jacqueline Palace, Daniel Lashley, John Newsom-Davis, Judy Cossins, Susan Maxwell, Robin Kennett, Sandeep Jayawant, Yuji Yamanashi, David Beeson.
- Journal Title
  
  Brain 130
  
  Pages: 1507-1515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.2006
- Author(s)
  Kumiko Okada, Akane Inoue, Momoko Okada, Yoji Murata, Shigeru Kakuta, Takafumi Jigami, Sachiko Kubo, Hirokazu Shiraishi, Katsumi Eguchi, Masakatsu Motomura, Tetsu Akiyama, Yoichiro Iwakura, Osamu Higuchi, Yuji Yamanashi.
- Journal Title
  
  Science 312
  
  Pages: 1802-1805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-7 mutations underlie a neuromuscular junction synaptopathy.2006
- Author(s)
  David Beeson, Osamu Higuchi, Jackie Palace, Judy Cossins, Hayley Spearman, Susan Maxwell, John Newsom-Davis, Georgina Burke, Peter Fawcett, Masakatsu Motomura, Juliane S.Muller, Hanns Lochmuller, Clarke Slater, Angela Vincent, Yuji Yamanashi.
- Journal Title
  
  Science 313
  
  Pages: 1975-1978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.2006
- Author(s)
  Miyuki Honma, Osamu Higuchi, Masaki Shirakata, Tomoharu Yasuda, Hiroshi Shibuya, Shun-ichiro Iemura, Tohru Natsume, Yuji Yamanashi.
- Journal Title
  
  Genes Cells 11
  
  Pages: 143-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] FLN29, a novel interferon-and LPS-inducible gene acting as a negative regulator of Toll-like receptor signaling.2005
- Author(s)
  Ryuichi Mashima, Kazuko Saeki, Daisuke Aki, Yasumasa Minoda, Hiromi Takaki, Takahito Sanada, Takshi Kobayashi, Hiroyuki Aburatani, Yuji Yamanashi, Akihiko Yoshimura.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 41289-41297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.2005
- Author(s)
  Hisaaki Shinohara, Akane Inoue, Noriko Toyama-Sorimachi, Yoshinori Nagai, Tomoharu Yasuda, Hiromi Suzuki, Reiko Horai, Yoichiro Iwakura, Tadashi Yamamoto, Hajime Karasuyama, Kensuke Miyake, Yuji Yamanashi.
- Journal Title
  
  J.Exp.Med. 201
  
  Pages: 333-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014030
[Journal Article] Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.2004
- Author(s)
  Tomoharu Yasuda, Masaki Shirakata, Atsushi Iwama, Asuka Ishii, Yasuhiro Ebihara, Mitsujiro Osawa, Kazuho Honda, Hisaaki Shinohara, Katsuko Sudo, Kohichiro Tsuji, Hiromitsu Nakauchi, Yoichiro Iwakura, Hisamaru Hirai, Hideaki Oda, Tadashi Yamamoto, Yuji Yamanashi
- Journal Title
  
  Journal of Experimental Medicine 200
  
  Pages: 1681-1687
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570154
[Journal Article] Placental extravillous cytotrophoblasts persistently express class I MHC molecules after human cytomegalovirus infection.2003
- Author(s)
  Masakazu Terauchi, Hideki Koi, Chikako Hayano, Noriko Toyama-Sorimachi, Hajime Karasuyama, Yuji Yamanashi, Takeshi Aso, Masaki Shirakata
- Journal Title
  
  Journal of Virology 77
  
  Pages: 8187-8195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570154
[Journal Article] CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation.2003
- Author(s)
  Ken-Ichi Imadome, Masaki Shirakata, Norio Shimizu, Shigeaki Nonoyama, Yuji Yamanashi
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 100
  
  Pages: 7836-7840
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570154
[Patent] Methods and Compositions for Treatment of Age-Related Dysfunction2021
- Inventor(s)
  山梨　裕司、植田　亮、杉田　聡、峯岸　慶彦
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00496
[Patent] Methods and Compositions for Treatment of Age-Related Dysfunction2020
- Inventor(s)
  山梨　裕司、植田　亮、杉田　聡、峯岸　慶彦
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-17H01532
[Patent] Methods and Compositions for Treatment of Age-Related Dysfunction2020
- Inventor(s)
  山梨　裕司、植田　亮、杉田　聡、峯岸　慶彦
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00496
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2007
- Inventor(s)
  山梨裕司, 他
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2007-04-26
- Overseas
- Data Source
  KAKENHI-PROJECT-20247024
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2007
- Inventor(s)
  山梨裕司, 他
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2007-12-05
- Overseas
- Data Source
  KAKENHI-PROJECT-20247024
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2007
- Inventor(s)
  山梨裕司, 他
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-20247024
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2007
- Inventor(s)
  山梨裕司、他
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2007-04-26
- Overseas
- Data Source
  KAKENHI-PROJECT-17014030
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2007
- Inventor(s)
  山梨裕司, 他
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-17014030
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2006
- Inventor(s)
  山梨裕司, 他
- Industrial Property Rights Holder
  東京医科歯科大学
- Industrial Property Number
  2006-158987
- Filing Date
  2006-06-07
- Data Source
  KAKENHI-PROJECT-17014030
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2006
- Inventor(s)
  山梨裕司, 樋口理, 岡田久未子, 井上茜
- Industrial Property Rights Holder
  東京医科歯科大学
- Industrial Property Number
  2006-158987
- Filing Date
  2006-06-07
- Data Source
  KAKENHI-PROJECT-17370066
[Patent] 筋特異的チロシンキナーゼの活性化を制御するポリペプチドをコードするDNA2006
- Inventor(s)
  山梨裕司他
- Industrial Property Rights Holder
  東京医科歯科大学
- Industrial Property Number
  2006-158987
- Filing Date
  2006-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17370066
[Presentation] 神経筋接合部を標的とする筋疾患の新規治療法の開発2022
- Author(s)
  山梨裕司
- Organizer
  第６３回日本神経学会学術集会（シンポジウム S-03-2）
- Invited
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] CDK5活性化因子p35を起点とした神経筋シナプス形成・維持制御メカニズムの解析2022
- Author(s)
  江口貴大、依田実朗、山梨裕司
- Organizer
  第８回日本筋学会学術集会（ポスター発表）
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] A study of therapeutic interventions aimed at enhancing neuromuscular junction innervation and skeletal muscle mass2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  The 16th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] 骨格筋における変異型CaMKIIβの強制発現は筋肥大を誘導する2021
- Author(s)
  江口貴大、范文蘭、山梨裕司
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] 神経筋シナプス（NMJ）形成シグナルとNMJ標的治療2020
- Author(s)
  山梨裕司
- Organizer
  第6回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04949
[Presentation] 神経筋接合部（NMJ）の形成増強治療は老齢マウスにおけるNMJの神経結合を増強し、運動機能と筋力を強化する2020
- Author(s)
  江口貴大、杉田聡、峯岸慶彦、下豊留玲、太田宣康、小木曽昇、植田亮、山梨裕司
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] 神経筋シナプス（NMJ）形成シグナルとNMJ標的治療2020
- Author(s)
  山梨裕司
- Organizer
  第6回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01532
[Presentation] 神経筋シナプス（NMJ）形成シグナルとNMJ標的治療2020
- Author(s)
  山梨裕司
- Organizer
  第6回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] DOK7発現ベクターの投与は老齢マウスのNMJにおける神経結合を増強し、運動機能と筋力を強化する2020
- Author(s)
  江口貴大、杉田聡、峯岸慶彦、下豊留玲、太田宣康、小木曽昇、植田亮、山梨裕司
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H00496
[Presentation] 神経筋接合部の出生後の維持におけるAgrinの新たな役割2015
- Author(s)
  手塚徹、井上茜、星太輔、Weatherbee SD、Burgess RW、植田亮、山梨裕司
- Organizer
  日本筋学会
- Place of Presentation
  国立研究開発法人国立精神・神経医療研究センター（東京都小平市）
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-25460357
[Presentation] Signaling in NMJ formation and a possible therapeutic approach2015
- Author(s)
  Yuji Yamanashi
- Organizer
  The 10th Japan-French Workshop on “New advances in treatments of neuromuscular diseases: From basic to applied myology”
- Place of Presentation
  Paris, France
- Year and Date
  2015-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-25117708
[Presentation] 神経筋シナプス形成シグナルとその制御2015
- Author(s)
  山梨裕司
- Organizer
  第１回日本筋学会学術集会
- Place of Presentation
  東京、日本
- Year and Date
  2015-08-08
- Invited
- Data Source
  KAKENHI-PUBLICLY-25117708
[Presentation] NMJ形成シグナルとその制御2014
- Author(s)
  山梨裕司
- Organizer
  研究班会議（精神・神経疾患研究開発費「筋ジストロフィーモデル動物を用いた新たな治療法の開発」）
- Place of Presentation
  東京都千代田区（ＪＡ共済ビル、カンファレンス・ホール）
- Year and Date
  2014-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-23249013
[Presentation] Dok-7, MuSK, and the development of the neuromuscular junction2012
- Author(s)
  Yuji Yamanashi
- Organizer
  12th International Conference on Myasthenia Gravis and Related Disorders (organized by the New York Academy of Sciences)
- Place of Presentation
  New York, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23249013
[Presentation] Plenary Lecture: Dok-7, MuSK, and the development of the neuromuscular junction2012
- Author(s)
  Yamanashi Y.
- Organizer
  12th International Conference on Myasthenia Gravis and Related Disorders (organized by the New York Academy of Sciences).
- Place of Presentation
  New York, USA.
- Data Source
  KAKENHI-PROJECT-23657113
[Presentation] Dok-7, MuSK, and the development of the neuromuscular junction2012
- Author(s)
  Yuji Yamanashi
- Organizer
  12th International Conference on Myasthenia Gravis and Related Disorders (organized by the New York Academy of Sciences)
- Place of Presentation
  New York, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23657113
[Presentation] 神経筋シナプスの形成とその破綻2010
- Author(s)
  山梨裕司
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)シンポジウム(1S3)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-20247024
[Presentation] Activation of a receptor kinase by an adaptor-like protein upon neuromuscular synaptogenesis.2009
- Author(s)
  Yuji Yamanashi
- Organizer
  In The 9th Korea-Japan Symposium on Cancer and Aging Research (Plenary Lecture)
- Place of Presentation
  Damyang, Korea.
- Year and Date
  2009-03-11
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7, MuSK, and the development of the neuromuscular junction.2009
- Author(s)
  Yuji Yamanashi
- Organizer
  In International Conference on Myasthenia Gravis (Plenary Lecture)
- Place of Presentation
  Paris, France.
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Plenary Lecture : Dok-7, MuSK, and the development of neuromuscular junction2009
- Author(s)
  Yuji Yamanashi
- Organizer
  International Conference on Myasthenia Gravis.(Organized by the EruroMyasthenia Network)
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-20247024
[Presentation] Dok-7 signaling and its defects in DOK7 myasthenia.2008
- Author(s)
  Yuji Yamanashi
- Organizer
  In The 15th East Asia Joint Conference on Biomedical Research (Invited)
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2008-07-22
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7/MuSK signaling and DOK7 myasthenia.2008
- Author(s)
  Yuji Yamanashi
- Organizer
  In Symposium 4S2 of The 31st Annual Meeting of the Molecular Biology Society of Japan and The 81st Annual Meeting of the Japanese Biochemical Society (Invited)
- Place of Presentation
  Kobe, Japan.
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7/MuSK シグナルの役割とその作用機序2008
- Author(s)
  井上茜、瀬戸口喜代子、樋口理、山梨裕司
- Organizer
  日本分子生物学会・日本生化学会合同年会BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19300142
[Presentation] Dok-7/MuSK signaling and DOK7 myasthenia.2008
- Author(s)
  Yuji Yamanashi
- Organizer
  In Symposium 1 of the 20th meeting of the Japanese Society for Neuroimmunology (Invited)
- Place of Presentation
  Niigata, Japan.
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7/MuSKシグナルの役割とその作用機序2008
- Author(s)
  井上茜、瀬戸口喜代子、樋口理、山梨裕司
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19300142
[Presentation] Dok-7型先天性筋無力症におけるDok-7蛋白質の機能異常2007
- Author(s)
  葉室浄香、樋口理、岡田久未子、上野真紀子、David Beeson、山梨裕司
- Organizer
  日本分子生物学会・日本生化学会合同年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19300142
[Presentation] Activation of the receptor tyrosine kinase MuSK by Dok-7 and myasthenia.2007
- Author(s)
  Yuji Yamanashi
- Organizer
  In Workshop 4W19 of The 30th Annual Meeting of the Molecular Biology Society of Japan and The 80th Annual Meeting of the Japanese Biochemical Society (Invited)
- Place of Presentation
  Yokohama, Japan.
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7/MuSK signaling and a congenital myasthenic syndrome.2007
- Author(s)
  Yuji Yamanashi
- Organizer
  In The 8th Japan-Korea Symposium on Cancer and Aging Research (Invited)
- Place of Presentation
  Gifu, Japan.
- Year and Date
  2007-08-11
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-7型先天性筋無力症におけるDok-7蛋白質の機能異常2007
- Author(s)
  葉室浄香、樋口理、岡田久未子、上野真紀子、David Beeson、山梨裕司
- Organizer
  日本分子生物学会・日本生化学会合同年会(BMB2007)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19300142
[Presentation] Dok-7/MuSK signaling and a congenital myasthenic syndrome.2007
- Author(s)
  Yuji Yamanashi
- Organizer
  In 7th Japanese-French Workshop on "Development of Molecular Therapy toward Muscular Dystrophy" (Invited)
- Place of Presentation
  Hayama, Japan.
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Dok-mediated signaling in Cancer and other disorders.2006
- Author(s)
  Yuji Yamanashi
- Organizer
  In Symposium 1 of 2006 Korean Society ofMedical Biochemistry and Molecular Biology Meeting (Invited)
- Place of Presentation
  Seoul, Korea.
- Year and Date
  2006-10-26
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Roles of the Dok-family adaptors in hematopoietic cells.2005
- Author(s)
  Yuji Yamanashi
- Organizer
  In The 7th Korea-Japan Symposium on Cancer and Aging Research (Invited)
- Place of Presentation
  Muju, Korea.
- Year and Date
  2005-11-04
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Roles of Dok-1 and Dok-2 in negative regulation of immune signaling.2005
- Author(s)
  Yuji Yamanashi
- Organizer
  In Symposium 9 of 2005 General Meeting of The Japanese Society for Immunology (Invited)
- Place of Presentation
  Yokohama, Japan.
- Year and Date
  2005-12-14
- Data Source
  KAKENHI-PROJECT-17014030
[Presentation] Regulation of cellular signaling by the Dok-family adaptors.
- Author(s)
  Yuji Yamanashi
- Organizer
  In 15th Endotoxin and LPS Meeting (Invited).
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-17014030

1. HIGUCHI Osamu (50361720)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
2. INOUE Junichiro (70176428)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SHIRAKATA Masaki (70251551)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. 清宮啓之 (50280623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. 根本知己 (50291084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. VERMA Inder M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. KATSURA Isao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
61. HANAOKA Fumio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
62. SUGANO Sumio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
63. YOKOYAMA Kazumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 橋本唯史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMANASHI YUJI 山梨 裕司

YAMANASHI Yuji 山梨 裕司

山梨 裕二 ヤマナシ ユウジ

山梨 裕司 ヤマナシ ユウジ

Research Projects

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Co-Researchers

生命科学連携推進協議会

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Signaling in NMJ formation and therapeutic intervention against neuromuscular disordersPrincipal Investigator

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神経筋伝達を担うアセチルコリン受容体の発現制御シグナルの解明Principal Investigator

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Molecular mechanisms underlying microenvironment-regulated tumor malignant progressionPrincipal Investigator

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Signaling in NMJ formation and its synaptopathyPrincipal Investigator

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Committee on Promoting Collaboration in Life SciencesPrincipal Investigator(Support)

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Studies on Metastasis of Colon Cancer Using Mouse Models

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NMJを起点とするdying-backパソロジーの解明Principal Investigator

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翻訳後修飾によるLrp4シグナル制御機構とその破綻Principal Investigator

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Molecular mechanisms of the formation and maintenance of NMJs

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アダプター分子の翻訳後修飾とその異常による疾患の解明Principal Investigator

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Molecular signaling in neuromuscular synaptogenesis and myastheniaPrincipal Investigator

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The role of Dok adaptors in pulmonary disorders

Principal Investigator

YAMANASHI YUJI 山梨裕司

YAMANASHI Yuji 山梨裕司

山梨裕二ヤマナシユウジ

山梨裕司ヤマナシユウジ