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MORISHIMA MAHO  森島 真帆

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… Alternative Names

MORISHIMA Maho  森島 真帆

森島 真帆  モリシマ マホ

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Researcher Number 50204722
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立精神・神経医療研究センター, 病院 臨床検査部 , 非常勤研究員
Affiliation (based on the past Project Information) *help 2013 – 2014: 北海道大学, 薬学研究科(研究院), 客員准教授
2012: 北海道大学, 薬学研究科(研究院), 招へい教員
2007 – 2011: Hokkaido University, Graduate School of Pharmaceutical Science, Associate professor
2009: 北海道大学, 薬学研究院, 特任准教授
2006: 東京大学, 大学院医学系研究科, 講師 … More
2002 – 2005: 東京大学, 大学院・医学系研究科, 講師
2004: University of Tokyo, Graduate School of Medicine, Lecturer, 大学院医学系研究科, 講師
2000 – 2001: 東京大学, 大学院・医学系研究科, 助手
1998: The Universi of Tokyo, Granduate School of Medicine, Instructor, 大学院・医学系研究科, 助手
1997: 東京大学, 大学院医学系研究科, 助手
1996: The university of Tokyo Faculty of Medicine, Research Associate, 医学部, 助手
1994: 東京大学, 医学部, 助手
1990: (財)東京都老人総合研究所, 神経生理部門, 研究員 Less
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / 老化(加齢) / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences
Except Principal Investigator
Biological Sciences / Neurochemistry/Neuropharmacology / Functional biochemistry / Neurology
Keywords
Principal Investigator
アルツハイマー病 / APP / アミロイドβタンパク質 / Alzheimer's disease / γセクレターゼ / amyloid β-protein / プレセニリン / ELISA / プロテアーゼ / γ-secretase … More / ラフト / 膜 / presenilin / γ-cleavage / γ切断 / low-denity membrane domains / amyloid beta-protein / 低密度膜ドメイン / βアミロイド蛋白 / 脳 / アルツハマー病 / 脳神経疾患 / リン酸化 / 神経変性 / PFCアッセイ / コンフォメーション / タウオパチー / タウ / ユビキチン / PHF … More
Except Principal Investigator
アルツハイマー病 / γセクレターゼ / Neuronal death / Neurofibrillary tangles / Tau / Alzheimer's disease / 神経細胞死 / 神経原線維変化 / タウ蛋白 / senile plaque / amyloidbeta-protein / Alzheimer's Disease / GM1ガングリオシド / preamyloid / diffuse plaque / β-amylodogenesis / 定量 / 髄膜 / アミロイドβ蛋白 / 老人斑 / β蛋白 / タンパク質分秋 / 細胞応答 / sシグナル伝達 / RIP / アミロイドβタンパク質 / 酵素 / タンパク質 / 認知症 / 脳・神経 / 脳神経疾患 / αヘリックス / 1型膜タンパク質 / APP / 膜内分解 / Aβ産生 / アミロイドβタンパク / トリペプチド仮説 / ε切断 / γ切断 / Alzheimer disease / 胎児抗原 / Sprouting / tau / Paired helical filaments / アルツハイマ-病 Less
  • Research Projects

    (12 results)
  • Research Products

    (72 results)
  • Co-Researchers

    (22 People)
  •  Characterization of gamma-secretase activity in the brain and its significance in the development of Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      MORISHIMA Maho
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Hokkaido University
  •  Identification of a regulatory factor for gamma-secretase activity generating Abeta40/Abeta 42 and its functional analysesPrincipal Investigator

    • Principal Investigator
      MORSHIMA Maho
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Hokkaido University
  •  タウのコンフォメーション変化のタウオパチーにおける意義と抑制法開発Principal Investigator

    • Principal Investigator
      森島 真帆
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  RIPによる細胞内情報伝達機構

    • Principal Investigator
      鈴木 利治
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Hokkaido University
  •  Amyloid β-protein production and metabolism of intramembrane regin of APPthrough stepwise processing.Principal Investigator

    • Principal Investigator
      MORISHIMA Maho
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Hokkaido University
      The University of Tokyo
  •  Characterization of the enzymatic properties of γ-secretase

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Doshisha University
      The University of Tokyo
  •  Molecular mechanisms of γ-cleavage for the generation of amyloid β-proteinPrincipal Investigator

    • Principal Investigator
      MORISHIMA Maho
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  Hyperphosphorylation and aggregation of tau protein, and neuronal death

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo
  •  Protein chemical analysis of amyloid beta-protein in the brain of early stages of beta-amyloidogenesisPrincipal Investigator

    • Principal Investigator
      MORISHIMA Maho
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      The Universi of Tokyo
  •  Studies on beta-amyloidogenesis-isolation of membrane-bound Abeta

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      University of Tokyo
  •  アルツハイマー病脳に蓄積するPHFにおけるユビキチン結合タンパク質の同定Principal Investigator

    • Principal Investigator
      森島 真帆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  アルツハイマ-病脳におけるSprouting仮説の生化学的検証

    • Principal Investigator
      IHARA Yasuo
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology

All 2014 2012 2011 2009 2008 2007 2006 2005 2004 2003 2001 2000 Other

All Journal Article Presentation Book

  • [Book] The Biology of Alzheimer Disease (The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease)2012

    • Author(s)
      Ihara Y, Morishima-Kawashima M, Nixon R.
    • Total Pages
      511
    • Publisher
      Cold Spring Harbor Laboratory Press
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Book] The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease. In The Biology of Alzheimer Disease2012

    • Author(s)
      Ihara Y, Morishima-Kawashima M, Nixon R
    • Publisher
      Cold Spring Harbor Laboratory Press
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Book] ユビキチン.認知症学(上)-その解明と治療の最新知見-2011

    • Author(s)
      森島真帆
    • Total Pages
      620
    • Publisher
      日本臨床
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Journal Article] Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase.2014

    • Author(s)
      Morishima-Kawashima M
    • Journal Title

      Frontiers in Physiology

      Volume: 8 Pages: 463-463

    • DOI

      10.3389/fphys.2014.00463

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Journal Article] γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.2014

    • Author(s)
      Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 8 Pages: 51095121-51095121

    • DOI

      10.1074/jbc.m113.510131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24500433
  • [Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease2014

    • Author(s)
      Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
    • Journal Title

      J. Alzheimers Dis

      Volume: 39 Issue: 4 Pages: 861-870

    • DOI

      10.3233/jad-131610

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24500433, KAKENHI-PROJECT-24591695, KAKENHI-PROJECT-24790062, KAKENHI-PROJECT-25460058, KAKENHI-PROJECT-25460059, KAKENHI-PROJECT-26293010
  • [Journal Article] Dissociation of beta-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer' s disease accelerates beta-amyloid-422011

    • Author(s)
      Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
    • Journal Title

      assembly. Neurosci Res

      Volume: 89 Issue: 6 Pages: 815-821

    • DOI

      10.1002/jnr.22615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500343, KAKENHI-PROJECT-21591069, KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-23659450
  • [Journal Article] γ-Secretase: Successive tri- and tetrapeptide release from the transmembrane domain of sCTF.2009

    • Author(s)
      Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y
    • Journal Title

      J Neurosci 29

      Pages: 13042-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Gamma-secretase : Successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment2009

    • Author(s)
      Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y
    • Journal Title

      J Neurosci

      Volume: 29 Pages: 13042-13052

    • URL

      http://www.jneurosci.org/content/29/41/13042.long

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Journal Article] Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.2008

    • Author(s)
      Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A
    • Journal Title

      J Biol Chem 283

      Pages: 16488-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Aβ46 is processed to Aβ40 and Aβ43, but not to Aβ42, in the low-density membrane domains.2008

    • Author(s)
      Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y.
    • Journal Title

      J Biol Chem 283(2)

      Pages: 733-738

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Journal Article] As46 is processed to As40 and As43, but not to As42, in the low-density membrane domains.2008

    • Author(s)
      Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y
    • Journal Title

      J Biol Chem 283

      Pages: 733-738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid β-protein concentration and lipid composition in brain low-density membrane domains2007

    • Author(s)
      Morishima-Kawashima M
    • Journal Title

      J Neurochem 101

      Pages: 949-958

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid β-protein concentration and lipid composition in brain low-density membrane domains.2007

    • Author(s)
      Morishima-Kawashima M, et. al.
    • Journal Title

      J. Neurochem. 101

      Pages: 949-958

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid B-protein concentration and lipid composition in brain low-density membrane domains.2007

    • Author(s)
      Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, 'Ihara Y.
    • Journal Title

      J Neurochem 101(4)

      Pages: 949-958

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid β-protein concentration and lipid composition in brain low-density membrane domains.2007

    • Author(s)
      Morishima-Kawashima M, et al.
    • Journal Title

      J. Neurochem. (Online Early Articles) 印刷中

    • Data Source
      KAKENHI-PROJECT-18500277
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid β-protein concentration and lipid composition in brain low-density membrane domains.2007

    • Author(s)
      Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y
    • Journal Title

      Journal of Neurochemistry (印刷中)

    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Effects of human apolipoprotein E isoforms on the amyloid s-protein concentration and lipid composition in brain low-density membrane domains.2007

    • Author(s)
      Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y
    • Journal Title

      J Neurochem 101

      Pages: 949-958

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Ihara Y. DAPT-induced intracellular accumulations of longer amyloid 13-proteins: Further implications for the mechanism of intramembrane cleavage by γ-secretase.2006

    • Author(s)
      Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S
    • Journal Title

      Biochemistry 45(12)

      Pages: 3952-3960

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Journal Article] DAPT-induced intracellular accumulations of longer amyloid s-proteins: further implications for the mechanism of intramembrane cleavage byγ-secretase.2006

    • Author(s)
      Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y
    • Journal Title

      Biochemistry 45

      Pages: 3952-3960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] DAPT-induced intracellular accumulations of longer amyloid β-proteins : further implications for the mechanism of intramembrane cleavage by γ-secretase.2006

    • Author(s)
      Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y
    • Journal Title

      Biochemistry 45

      Pages: 3952-3960

    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Longer forms of amyloid β-protein : implications for the mechanism of intramembranous cleavage by y-secretase.2005

    • Author(s)
      Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Hirotani N, Horikoshi Y, Maeda M, Saido TC, Ihara Y
    • Journal Title

      J Neurosci 25

      Pages: 436-445

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Longer forms of amyloid s-protein: implications for the mechanism of intramembranous cleavage byγ-secretase.2005

    • Author(s)
      Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Hirotani N, Horikoshi Y, Maeda M, Saido TC, Ihara Y
    • Journal Title

      J Neurosci 25

      Pages: 436-445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex.2005

    • Author(s)
      Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y
    • Journal Title

      Neurology 64

      Pages: 687-692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Blocking the cleavage at midportion between γ- and ε-sites remarkably suppresses the generation of amyloid β-protein.2005

    • Author(s)
      Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawasdhima M, Ihara Y
    • Journal Title

      FEBS Lett 579

      Pages: 2907-2912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Independent accumulations of tau and amyloid s-protein in the human entorhinal cortex2005

    • Author(s)
      Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y
    • Journal Title

      Neurology 64

      Pages: 687-692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads.2005

    • Author(s)
      Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DMA, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y
    • Journal Title

      J Neuropathol Exp Neurol 64

      Pages: 665-674

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads2005

    • Author(s)
      Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DMA, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y
    • Journal Title

      J Neuropathol Exp Neurol 64

      Pages: 665-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Blocking the cleavage at midportion betweenγ- andε-sites remarkably suppresses the generation of amyloid s-protein2005

    • Author(s)
      Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawasdhima M, Ihara Y
    • Journal Title

      FEBS Lett 579

      Pages: 2907-2912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Journal Article] Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid Β-proteins 40 and 42.2004

    • Author(s)
      Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y
    • Journal Title

      Biochemistry 43

      Pages: 13532-13540

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Molecular aging of tau : disulfide-independent aggregation and nonenzymatic degradation in vitro and in vivo.2004

    • Author(s)
      Watanabe A, Hong W-K, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y
    • Journal Title

      J Neurochem 90

      Pages: 1302-1311

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Potential link between amyloid β-protein 42 and C-terminal fragment γ49-99 of β-amyloid precursor protein.2003

    • Author(s)
      Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y
    • Journal Title

      J Biol Chem 278

      Pages: 24294-24301

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] γ-Secretase activity is present in rafts, but not cholesterol-dependent.2003

    • Author(s)
      Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y
    • Journal Title

      Biochemistry 42

      Pages: 13977-13986

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid β-protein 42 in Chinese hamster ovary cells.2003

    • Author(s)
      Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y
    • Journal Title

      Biochemistry 42

      Pages: 1042-1052

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation.2001

    • Author(s)
      Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima, K, Ihara Y
    • Journal Title

      J Neuropathol Exp Neurol 60

      Pages: 872-884

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Molecular analysis of mutant and wild-type tau deposited in the brain affected by FTDP-17 R406W mutation.2001

    • Author(s)
      Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y
    • Journal Title

      Am J Pathol 158

      Pages: 373-379

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.2001

    • Author(s)
      Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y
    • Journal Title

      Am J Pathol 158

      Pages: 2209-2218

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain.2000

    • Author(s)
      Morishima-Kawashima M, et al.
    • Journal Title

      Am J Pathol 157

      Pages: 2093-2099

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Mutant-presenilin 2-transgenic mice : A large increase in the levels of Aβ42 is presumably associated with the low-density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.2000

    • Author(s)
      Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Ito M, Oyama F, Ando S, Ihara Y
    • Journal Title

      J Biol Chem 275

      Pages: 27901-27908

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain.2000

    • Author(s)
      Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y
    • Journal Title

      Am J Pathol 157

      Pages: 2093-2099

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Journal Article] Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells.2000

    • Author(s)
      Misonou H, Morishima-Kawashima M, Ihara Y
    • Journal Title

      Biochemistry 39

      Pages: 6951-6959

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210005
  • [Presentation] DRMにおけるγセクレターゼのAPP切断機序2012

    • Author(s)
      松村展敬,高見真子,井原康夫,森島真帆
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構.2012

    • Author(s)
      松村展敬,高見真子,田上真次,大河内正康,井原康夫,森島真帆.
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば国際会議場 (茨城県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Presentation] マウス脳γセクレターゼ活性の解析2011

    • Author(s)
      宮本一仁,孫瑜,松村展敬,森島真帆
    • Organizer
      第30回日本認知症学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Presentation] Protein-fragment complementationアッセイ法を用いたタウの凝集体形成過程の解析2009

    • Author(s)
      松村展敬、宮坂知宏、吉名佐和子、中台枝里子、三谷昌平、井原康夫、森島真帆
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] Protein-fragment complementationアッセイ法を用いたタウの凝集体形成過程の解析2009

    • Author(s)
      松村展敬,宮坂知宏,千野拓,吉名佐和子,中台枝里子,三谷昌平,井原康夫,森島真帆
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      東北大学百周年記念会館(仙台市)
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-21500343
  • [Presentation] γ-Secretase : Intramembrane cleavage of B-amyloid precursor protein2008

    • Author(s)
      Morishima-Kawashima M
    • Organizer
      第51回日本神経化学会大会シンポジウム
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-13
    • Data Source
      KAKENHI-PROJECT-20023002
  • [Presentation] APP cleavage by g-secretase: To test the tripeptide hypothesis using LC-MS/MS2008

    • Author(s)
      Takami M, Sano Y, Funamoto S, Tsuji S, Morishima M, Ihara Y
    • Organizer
      ICAD
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] γセクレターゼ:APP膜内切断のメカニズムと創薬の可能性2008

    • Author(s)
      森島 真帆
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2008-03-28
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] γ-Secretase: Mechanism of intramembrane cleavage of APP and possible drug discovery2008

    • Author(s)
      Morishima-Kawashima M
    • Organizer
      The 128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama(Pacifico YOKOHAMA)
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] γセクレターゼ: APP膜内切断のメカニズムと創薬の可能性2008

    • Author(s)
      森島真帆
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜(横浜パシフィコ)
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Lipid rafts and Abeta production2007

    • Author(s)
      Morishima-Kawashima M
    • Organizer
      Neuro2007(第30回日本神経科学大会/第50回日本神経化学会大会/第17回日本神経回路学会大会, 合同大会)
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2007-09-12
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Lipid rafts and Abeta production.2007

    • Author(s)
      Morishima-Kawashima M
    • Organizer
      Neuro2007(第30回日本神経科学大会/第50回日本神経化学会大会/第17回日本神経回路学会大会, 合同大会)
    • Place of Presentation
      横浜(横浜パシフイコ)
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Lipid rafts and Abeta production.2007

    • Author(s)
      Morishima-Kawashima M.
    • Organizer
      Neuro 2007
    • Place of Presentation
      Yokohama (Pacifico YOKOHAMA)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Stepwise processing of s-amyloid precursor protein byγ-secretase.2006

    • Author(s)
      Morishima-Kawashima M, Ihara Y.
    • Organizer
      International Symposium on "Medical and Biological Perspectives in Proteases and Their Inhibitors"
    • Place of Presentation
      Awaji, Hyogo
    • Year and Date
      2006-06-26
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] γ-Secretase: Relationship between γ-cleavage and ε-cleavage.2006

    • Author(s)
      Morishima-Kawashima M, et. al.
    • Organizer
      The 10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid (Spain) (Contro de Convenciones)
    • Year and Date
      2006-07-16
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Effects of apoE isoforms on Aβ concentration and lipid composition in the brain LDM domains.2006

    • Author(s)
      Morishima-Kawashima M, et. al.
    • Organizer
      第25回日本認知症学会
    • Place of Presentation
      広島(広島国際会議場)
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Effects of apoE isoforms on Aβ concentration and lipid composition inn the brain LDM domains.2006

    • Author(s)
      Morishima-Kawashima M, Tanimura Y, Hamanaka H, Nukina N, Fujita SC, Ihara Y.
    • Organizer
      The 6th Annual Meeting of International College of Geriatric Psychoneuropharmacology (ICGP)
    • Place of Presentation
      Hiroshima (International conference center .HIEROSHIMA )
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Effects of human apoE isoforms on the As concentration and lipid composition in low-density membrane domains of the brain.2006

    • Author(s)
      Morishima M, Tanimura Y, Hamanaka H, Nukina N, Fujita S, Ihara Y
    • Organizer
      ICGP and JSDS joint meeting
    • Place of Presentation
      Hiroshima
    • Year and Date
      2006-10-06
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] Stepwise processing of β-amyloid precursor protein by γ-secretase.2006

    • Author(s)
      Morishima-Kawashima M, et. al.
    • Organizer
      International Symposium on "Medical and Biological Perspectives in Proteases and Their Inhibitors"
    • Place of Presentation
      Awaji, Hyoao(淡路夢舞台国際会議場)
    • Year and Date
      2006-06-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Stepwise processing of 13-amyloid precursor protein by γ-secretase.2006

    • Author(s)
      Morishima-Kawashima M, Ihara Y.
    • Organizer
      International Symposium on "Medical and Biological Perspectives in Proteases and Their Inhibitors"
    • Place of Presentation
      Awaji, Hyogo (Awaji Yumebutai' international Conference Center)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] γ-Secretase: Relationship between y-cleavage and e-cleavage2006

    • Author(s)
      Morishima-Kawashima M, Ihara Y.
    • Organizer
      The 10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid (Spain)(Contro de Conventions')
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18500277
  • [Presentation] Relationship between g-cleavage and e-cleavage.2006

    • Author(s)
      Morishima-Kawashima M, Ihara Y. g-Secretase
    • Organizer
      The 10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid (Spain)
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] The mechanism of APP cleavage byγ-secretase: To test the tripeptide hypothesis using LCMSMS.2006

    • Author(s)
      Takami M, Morishima M, Okochi M, Ihara Y
    • Organizer
      第25回日本認知症学会
    • Place of Presentation
      広島
    • Year and Date
      2006-10-06
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] γセクレターゼ阻害剤DAPTの細胞内Aβに対する影響2005

    • Author(s)
      柳下聡介、森島真帆、石浦章一、井原康夫
    • Organizer
      第24回日本痴呆学会
    • Place of Presentation
      大阪
    • Year and Date
      2005-09-30
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] Visualization of newly deposited tau in neurofibirillary tangles and neuropil thread. Mini-symposium2005

    • Author(s)
      宮坂知宏、渡邊淳、斉藤祐子、村山繁雄、マンデビッド、山崎峰雄、レイビッドリブカ、森島真帆、井原康夫
    • Organizer
      第48回神経化学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] Stepwise processing of sCTF in As production: Analysis using lipid rafts.

    • Author(s)
      Yagishita S, Morishima M, Ishiura S, Ihara Y
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-17025008
  • [Presentation] X11Lの構造変換によるAPPの輸送・代謝制御機構.

    • Author(s)
      本館利佳,齋藤優実,森島真帆,齋藤有紀,鈴木利治.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Presentation] Alcadein代謝産物による機能発現.

    • Author(s)
      江波綾佳,朴懿,森島真帆,羽田沙緒里,鈴木利治.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Presentation] てんかん発作、アルツハイマー病発症におけるX11/X11Lの関与.

    • Author(s)
      木村尚紀,齋藤有紀,井上剛,森島真帆,鈴木利治.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Presentation] Alcadeinのリン酸化.

    • Author(s)
      蘇武佑里子,古郡慶子,森島真帆,羽田沙緒里,鈴木利治.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • [Presentation] Alcadeinによるkinesin-1活性と膜小胞輸送制御機構.

    • Author(s)
      白木柚葉,河野高徳,千葉杏子,森島真帆,山本融,鈴木利治.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡 (福岡県)
    • Data Source
      KAKENHI-PROJECT-24500433
  • 1.  IHARA Yasuo (60114386)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 35 results
  • 2.  FUNAMOTO Satoru (10345043)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  YAMAZAKI Tsuneo (80200658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  IWATSUBO Takeshi (50223409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YANAGISAWA Katsuhiko (10230260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIYASAKA Tomohiro (90342857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  ITO Mamoru (00176364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  FUJITA Shinobu (30092323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  金丸 和富 (10214488)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  森 啓 (10159189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  鈴木 利治 (80179233)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  駒野 宏人 (40170378)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  矢部 大介 (60378643)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  西村 正樹 (40322739)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  石浦 章一 (10158743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  松村 展敬 (60327707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  元永 耕三 (20345044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  小山 文隆 (40194641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  岡澤 均 (50261996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  小河原 緑
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  TAGAMI Shinji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  大河内 正康
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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