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HIGASHIYAMA Shigeki  東山 繁樹

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Researcher Number 60202272
Other IDs
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Affiliation (Current) 2025: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 腫瘍増殖制御学部 部長
Affiliation (based on the past Project Information) *help 2013 – 2024: 愛媛大学, プロテオサイエンスセンター, 教授
2015: 愛媛大学, プロテサイエンスセンター, 教授
2015: 愛媛大学, 学内共同利用施設等, 教授
2014 – 2015: 愛媛大学, 大学院医学系研究科, 教授
2009 – 2013: Ehime University, プロテオ医学研究センター, 教授 … More
2012: 愛媛大学, 大学院・医学系研究科, 教授
2011: 愛媛大学, 医学部, 教授
2006 – 2009: Ehime University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授
2006: Ehime University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授
2002 – 2006: Ehime University, Faculty of Medicine, Professor, 医学部, 教授
2005: 愛知大学, 医学部, 教授
2001: 大阪大学, 医学部・保健学科, 助教授
1999 – 2001: OSAKA UNIVERSITY, BIOCHEMISTRY, ASSOCIATE PROFESSOR, 医学部, 助教授
2000: 大阪大学, 医学系研究科, 助教授
1999: 大阪大学, 医学部・基礎生体情報学, 助教授
1993 – 1998: 大阪大学, 医学部, 助手
1994 – 1996: 大阪大学, 医学部生化学教室, 助手 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Basic Section 50010:Tumor biology-related / Medium-sized Section 50:Oncology and related fields / Pathological medical chemistry / Biological Sciences / Biological Sciences / Functional biochemistry / Structural biochemistry / Tumor biology / Laboratory medicine / Tumor biology … More
Except Principal Investigator
… More Gastroenterology / Basic Section 56030:Urology-related / Pathological medical chemistry / Dermatology / Endocrinology / Dermatology / Cell biology / 内分泌・代謝学 / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 55020:Digestive surgery-related / Basic Section 44010:Cell biology-related / General medical chemistry / Urology / Radiation science / Experimental pathology / Gastroenterology / Developmental biology / Human pathology / Pathological medical chemistry / Structural biochemistry / Functional biochemistry / Nerve anatomy/Neuropathology / Pediatrics / Digestive surgery / Science and Engineering / General surgery / Biological Sciences Less
Keywords
Principal Investigator
HB-EGF / shedding / Shedding / PLZF / ユビキチンリガーゼ / amphiregulin / EGFファミリー / metalloprotease / EGF family / CUL3 … More / cullin3 / keratinocyte / EGFR / wound healing / タンパク質分解 / 膜型増殖因子 / ADAM / repressor / Transcriptional repressor / ジャクスタクリン活性 / SPOP / proHB-EGF / Cullin3 / CTF / epiregulin / c-myc / レトログレード小胞輸送 / neuregulin / NTAK / PKC / セレクターゼ / HER2 / Phosphatase / CNKSR1 / DNAアプタマー / アクチンダイナミクス / RhoB / KCTD10 / PDGF / EGF / bFGF / gene regulation / SH3 protein / cell migration / ゆらぎ / エクトドメイン・シェディング / proamphiregulin / がん微小環境 / 腫瘍血管新生 / 核膜移行 / エンドサイトーシス / 細胞増殖 / 増殖因子 / 小胞輸送 / Metalloprotease / SH3蛋白質 / IL-8 / 胃がん / Rab / HER1/2 陽性がん / K-Ras 変異 / DNA アプタマー / K-Ras / がん治療 / K-Ras変異 / HER / ユビキチン リガーゼ / 阻害剤 / チロシンフォスファターゼ / CUL3 ユビキチンリガーゼ / EGFR/HER2 / PTPRH / プロテインアレイ / CUL3 ユビキチン リガーゼ / PTPRH・PTPRJ / プロテインチロシンホスファターゼ / HER2陽性乳がん / 標的タンパク質分解 / ユビオキチンリガーゼ / DNA-アプタマー / ユビキチン化 / CBF1 / protein targeting / DNA aptamer / シェディング / ユビキチンE3リガーゼシ / エクトドメイン・シェディング” / Amphiregulin / 膜型細胞増殖因子 / RhoA / 乳がん細胞 / がん細胞の不均一性 / 翻訳後修飾 / CUL3型ユビキチンリガーゼ / エピゲノム / シグナル伝達 / タンパク質翻訳後修飾 / BTBP / integrin beta1 / BTBドメイン含有タンパク質 / Rnd2 / 血管内皮細胞 / VEGFR2 / ANKFY1 / BTBドメインタンパク質 / 血管新生 / cell cycle progression / γ-セクレターゼ / メタロプロテアーゼ / ampbiregulin / TGF-α / EGF-ファミリー / 細胞周期進行 / Wound Healing / PACSIN3 / Angiotensin II / Keratinocyte / 細胞株 / ケラチノサイト / 創傷治癒 / Cell differentiation / Cell growth / ErbB tyrosine kinase / Neuregulin / EGF ファミリー / ErbB チロシンキナーゼ / 細胞分化 / ErbBチロシンキナーゼ / 細胞形質転換 / がん細胞不均一性 / 無細胞蛋白質合成 / MRM / 炎症 / 蛋白質絶対定量 / 炎症マーカー / 無細胞タンパク質合成 / shedding定量 / プロテオミクス / プロテオーム解析 / タンパク質絶対定量 / 臨床検査システム / TNF-α / Ectodomain Shedding / 細胞膜蛋白質 / TNF-alpha / レムナントペプチドシグナル / annexin / proTNF-α / ADAM17 / ectodomian shedding / BAZF / Notch / VEGF / 抗がん剤抵抗性 / 膜型プロテアーゼ / ER/核膜移行 / がん細胞の特性 / ectodomain shedding / 細胞増殖抑制 / Pbx 1 / Bcl6 / BCL6 / HB-EGF-CTF / 転写リプレッサー / CTFシグナル / シグナル伝達と遺伝子発現 / vesicle transport / endocytosis / membrane protein / neuclear import / CTF signal / recycling endosome / Juxtacrine growth / Tumor survival / EGFRトランス活性化 / claudin / cell adhesion molecule / Tight junction / ErbB4 / ErbB3 / ErbB2 / CD9 / EGF受容体 / オートクリン活性 … More
Except Principal Investigator
HB-EGF / 増殖因子 / ADAM / 血管新生 / シグナル伝達 / ユビキチンリガーゼ / CUL3 / 細胞接着 / インテグリン / 血管内皮細胞 / 前立腺癌 / Growth factor / EGFファミリー / 癌の転移 / PSMA / Diabetes mellitus / Regeneration / Betacellulin / EGF / 再生 / 糖尿病 / 分化 / β細胞 / EGF受容体 / 炎症性腸疾患 / shedding / 胃癌 / IL-8 / 転写因子 / 核膜 / アポトーシス / neuregulin / カドヘリン / EGF family / 一酸化窒素 / 活性酸素 / シングルセル解析 / CRL3 / ユビキチンE3リガーゼ / 質量分析法 / ユビキチン / 大腸癌 / Bcl6 / RT-PCR / siRNA / GPCR / Pax6 / ベータセルリン / GFP / growth factor / Differentiation / ベータセルリン(Betacellulin) / 遺伝子治療 / Signal transduction / Apoptosis / Reactive oxygen species / integrin / CD9 / TNF-α / TNFα / ADAM17 / 上皮間葉転換 / 乳腺細胞 / HB-EGF-CTF / 治療 / 炎症性サイトカイン / メンブレントラフィック / 細胞増殖 / 細胞運動 / 血管新生因子 / 接着分子 / MAPキナーゼ / 細胞増殖因子 / アンギオプロテオスタシス / 腫瘍血管 / 腸管慢性炎症発がん / cullin3 / E3ユビキチンリガーゼ / 腸管慢性炎症 / 導管癌 / 神経内分泌癌 / 遺伝子解析 / 神経内分泌分化 / IDCP / 空間的遺伝子発現解析 / 神経内分泌前立腺癌 / 腎癌 / 腎がん / プロテオスタシス / KCTD10 / 髄芽腫 / 新規治療戦略 / 血管腫 / ケラチノサイト / 血管奇形 / タンパク質代謝マーカー / NRM解析 / 定量質量分析 / CUL3型ユビキチンリガーゼ / がんマーカー / 大腸がん / バイオマーカー / KLHL5 / Cullin3型ユビキチンリガーゼ / prostate cancer specimen / tube formation / LNCaP / HUVECs / tumor endothelial cells / SUN1 / 情報伝達 / LINC complex / LINC複合体 / 核膜タンパク質 / 細胞接着装置 / lamin / nesprin / SUN / 核 / 細胞核 / 核小体 / ゴルジ体 / メカノトランスダクション / LINC 複合体 / Integrin β1 / 細胞内膜輸送 / 腫瘍学 / AlphaScreen法 / SPOP / 前立腺がん / CUL3 / PD-L1 / BTB蛋白 / 胃がん / Cullin-3 / PD-L1/PD-1 / Cullin3 / TNF-alfa / Annexin A2 / Annexin A2 / Amphiregulin / EGFR / リン酸化酵素阻害剤 / 乳がん細胞 / CRISPR / RSK / RSK2 / transcriptional repressor / cell death / cardiac myocytosis / cardiomyocyte / 転写抑制因子 / 分化誘導 / 転写制御因子 / 細胞死 / 心筋症 / 心筋細胞 / membrane traffic / nuclear envelope / メンブレントラフィッキング / エンドサイトーシス / EGF様増殖因子 / ヘパリン結合型EGF様増殖因子 / trafficking into nucleu / HB-EGF C terminus / C末端 / c-myc / PLZA / HB-EGF C 末端 / 核内移行 / HB-EGF C末端 / Agents intercepting tumor blood stream / Metastatic potential / Radiation field margin / Gene / DNA chip / Carbon-ion beam / X-ray / 血管新生能 / 浸潤能 / 増殖能 / 細胞生存率 / 重粒子線 / 腫瘍血流遮断薬 / 転移能 / 照射野辺縁 / 遺伝子 / DNAチップ / 炭素イオン線 / X線 / disintegrin / metalloproteinase / cancer metastasis / 肺癌 / 脳転移 / )ディスインテグリン / ディスインテグリン / メタロプロテアーゼ / EGFR ligands / inflammatory cytokines / shelding / EGFR ligand / IL-1β / EGFR ligsnds / male mouse mammary gland / collagen gel / epithelial-mesenchymal interactions / morphogenesis / mouse submandibular gland / 雄乳腺 / マウス乳腺 / マウス雄乳腺 / コラーゲンゲル / 上皮-間充織相互作用 / 形態形成 / マウス唾液腺 / Heparin-binding EGF-like growth factor (HB-EGF) / Gene therapy / Differentioation / β cell / Transcription factor / βcell / Paxファミリー / transfection / integrin α4β1 / chemotherapy / bone metastasis / 破骨細胞 / 骨髄 / VCAM-1 / 遺伝子導入 / インテグリンα4β1 / 抗癌剤 / 骨転移 / CELL ADHESION MOLECULE / ADENOVIRUS VECTOR / THREE DIMENTIONAL RECONSTITUTED SKIN / ARTIFICIAL SKIN / アデノウィルスベクター / 三次元培養 / 細胞接着分子 / アデノウイルスベクター / 三次元培養皮膚 / 人工皮膚 / glutathione peroxidase / redox balance / nitric oxide / glutathine / ペルオキシレドキシン / NO合成酵素 / ベルオキシレドキシン / チオレドキシン / セルロプラスミン / グルタチオン / EGF receptor / EGF-受容体 / Alloxan / beta cell / EGFレセプター / アロキサン / Keratin 1 and 10 / Keratin 5 and 14 / Involucrin / TGF-alpha / Autocrine Growth Factor / Cell Differntiation / Epidermal Keratinocyte / ケラチン1、10 / ケラチン5、14 / インポルクリン / ケラチン1,10 / ケラチン5,14 / インボルクリン / TGF-α / オートクリン細胞増殖因子 / 細胞分化誘導 / 表皮ケラチノサイト / cardiovascular remodeling / aging / atherosclerosis / phenotypic modulation / gene expression / gene therapy / smooth muscle / blood vessels / アテレクトミ- / 組織因子 / Znフィンガー / INOS / プロモーター / BTEB2 / 血管平滑筋 / Klotho / Smooth muscle / カルポニン / クロマチン転写 / klotho / 心血管リモデリング / 老化 / 動脈硬化 / 形質変換 / 遺伝子発現調節 / 平滑筋 / 血管 / 3-Deoxyglucosone / Glycation / Diabetic complications / Antioxidants / グルタチオンペルオキシダーゼ / スーパーオキシドディスムターゼ / 2-オキソアルデヒド化合物 / ヘパリン結合性上皮増殖因子 / 形質転換増殖因子 / 3-デオキシグルコソン / グリケーション / 糖尿病性合併症 / 抗酸化剤 / 活性酸素種 / neuronal network / embryo / mouse / axon repusion / axon guidance / growth cone collapse / semaphorin / collapsin / コプラシン / 神経回路形成 / 反発因子 / 誘導因子 / 神経軸索 / 反発分子 / 軸索 / コラプシン / セマフォリン / 発生 / 軸索反発分子 / コラプス / 成長円錐 / マウス / 神経回路 / membrane-anchored growth factors / haparansulfate proteoglycans / TM4 / juxtacrine / ジフテリア毒素リセプター / 膜結合型細胞増殖因子 / ヘパラン硫酸プロテオグリカン / TM4ファミリー / ジャクスタクライン / 白血病幹細胞 / MLL融合遺伝子 / 融合遺伝子 / 白血病 / 小児血液学 / 新規治療ターゲット / ARP36-2 / 乳腺上皮細胞 / 細胞内シグナル / シェディング / 血管内皮増殖因子 / 細胞遊走 / ヒアルロン酸 / 細胞間接着 / 遺伝子改変マウス / 細胞内シグナル伝達 / リンパ管新生 / 潰瘍性大腸炎 / colitic cancer / Alphascreen assay / PLZF / HB-EGF核移行シグナル / EGF-receptor / epiregulin / amphiregulin / cyclinD2 / c-Myc / 癌治療戦略 / BCL6 / HB-EGF shedding / モノクローナル抗体 / 炎症 / 細胞制御 / 癌 / リンパ管内皮細胞 / 細胞外マトリックス / ectodomain shedding / EGF 増殖因子 / アンチトロンビン / ウリナスタチン / 転移 / セリン・プロテアーゼ / プロテアーゼインヒビター / 細胞浸潤 / 癌治療 / 細胞外基質 / 海洋生物 / 基質分解酵素 / 転移の臓器特異性 / G蛋白共役型リセプター / トランスアクチベーション / 遺伝子ターゲッティング / カテニン / 糖転移酵素 / 糖鎖 / STAT / プロセッシング / 膜アンカー型 / 創傷治癒 / 角化細胞 / c-kit受容体 / インスリン受容体 / 細胞増殖抑制 / Sky / Gas6 / GLUT4のトランスロケーション / ソマトスタチン / ガストリン受容体 / ErbB3 / インスリンシグナル伝達系 / スルホニール尿素受容体 / HEP受容体 / ErbBリガンド / c-Met受容体 / HGF / 細胞増殖制御 / Ras蛋白質 / がん細胞の浸潤性 / 肝細胞増殖因子 / 脱ユビキチン化酵素 / SH3ドメイン / Hrs結合蛋白質 / がん細胞の増殖制御 / c-Met / 肝細胞増殖因子(HGF) / HB-EGF(heparin-binding EGF-like growth factor) / BTC(betacellulin) / 膵β細胞 / IL-1 / TNF / 卵巣癌 / 過酸化物 / 抗酸化酵素 / Mn-スーパーオキサイドディスムターゼ / 腫瘍マーカー Less
  • Research Projects

    (78 results)
  • Research Products

    (350 results)
  • Co-Researchers

    (135 People)
  •  受容体型チロシンキナーゼHERの新規活性抑制機構に基づく創薬とがん治療応用Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Ehime University
  •  Studies of medulloblastoma associating angiogenesis based on CRL3

    • Principal Investigator
      田手 壮太
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Ehime University
  •  腎癌関連血管内皮細胞におけるPSMAの発現制御機構及び、その分子機能の解明

    • Principal Investigator
      菊川 忠彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Ehime University
  •  シングルセル解析による腫瘍微小環境を介した前立腺神経内分泌腫瘍発生機序の解明

    • Principal Investigator
      渡辺 隆太
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Ehime University
  •  International collaboration research on the identification of novel driver genes for prostate cancer by single cell analysis.

    • Principal Investigator
      菊川 忠彦
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Ehime University
  •  腸管慢性炎症からがんの発症・進展を誘導する血管リモデリングの解明

    • Principal Investigator
      渡部 祐司
    • Project Period (FY)
      2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Ehime University
  •  Regulation of HER1/2 receptor tyrosine kinases by RhoB-CNKSR1 complexPrincipal Investigator

    • Principal Investigator
      Higashiyama Shigeki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Ehime University
  •  Regulatory mechanisms of PSMA expression and its molecular functions in prostate cancer-associated vascular endothelial cells.

    • Principal Investigator
      Miura Noriyoshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Ehime University
  •  Development of disease-specific protein-targeting technologyPrincipal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Ehime University
  •  Identification and clinical application of the colon cancer-specific protein markers

    • Principal Investigator
      Watanabe Yuji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Ehime University
  •  Creation of new therapeutic strategies for vascular malformations by targeting the ubiquitin E3 complex

    • Principal Investigator
      Nakaoka Hiroki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56070:Plastic and reconstructive surgery-related
    • Research Institution
      Ehime University
  •  Development and application of disease-specific protein targeting systemPrincipal Investigator

    • Principal Investigator
      Higashiyama Shigeki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Ehime University
  •  LINC complex functions in signal transduction pathways at the nuclear envelope

    • Principal Investigator
      Hieda Miki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Ehime Prefectural University of Health Science
  •  Analysis of the molecular mechanism of PSMA in prostate cancer cells

    • Principal Investigator
      Miura Noriyoshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Ehime University
  •  Membrane trafficking system of PD-L1 in gastric cancer cells and its application to immunotherapy

    • Principal Investigator
      Joh Takashi
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  The identification of CUL3-SPOP and CUL3-PLZF target substrates for therapeutic targets in prostate cancer cells

    • Principal Investigator
      Kikugawa Tadahiko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Ehime University
  •  CUL3 network system in angiogenesisPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA SHIGEKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Ehime University
  •  Fluctuation of ectodomain shedding and the emersion of cancer cell heterogeneityPrincipal Investigator

    • Principal Investigator
      Higashiyama Shigeki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Molecular basis of angiogenesis regulated by CUL3-dependent membrane trafficking

    • Principal Investigator
      Maekawa Masashi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Reversible interconversin of mammary epithelial cells by EGF ligands

    • Principal Investigator
      Fukuda Shinji
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Ehime University
  •  Study on the fluctuation of ectodomain shedding and its application to predict cancer cell dynamicsPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA SHIGEKI
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  新たな血管新生バランス制御因子CUL3の多機能解析Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Ehime University
  •  Identification of targetable leukemogenic pathway and leukemic stem cells in MLL fusion-positive leukemia

    • Principal Investigator
      EGUCHI MARIKO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Ehime University
  •  Advances in refractory IBD treatment: a new therapeutic target, Annexin A2

    • Principal Investigator
      Tanida Satoshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  Regulation of ectodomian shedding by ADAM17 and remnant signalingPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Role of growth factor and cytokine singaling in the determination of mammary epithelial cell characteristics

    • Principal Investigator
      FUKUDA Shinji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Ehime University
  •  Development of membrane protein function analysis and the new suppression mediated by the tumor necrosis factor precursor and producing enzyme

    • Principal Investigator
      JOH Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  Absolute Quantification of Transmembrane Protein Shedding and Its Application to the Monitoring of Chronic InflammationPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Ehime University
  •  Development of HB-EGF-CTF related therapy and biomarker for gastrointestinal cancer

    • Principal Investigator
      Shimura Takaya
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  血管内皮細胞の増殖促進と抑制の新規バランス制御分子による腫瘍血管新生制御の解析Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Ehime University
  •  Biochemical process of membrane-associated protein is induced by inflammatory cytokines in cultured lymphatic endothelial cells

    • Principal Investigator
      HIRAKAWA Satoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Hamamatsu University School of Medicine
  •  Potential of new anti-cancer agents targeting the nuclear translocation signaling of HB-EGF C-terminal fragments

    • Principal Investigator
      TANIDA Satoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  Molecular mechanism of auto-translocation of membrane anchored EGFR ligand into the nuclear membrane and its diagnostic application of cancerPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Ehime University
  •  To clarify the mechanism that C terminal fragments of EGFR ligand cause nuclear export of transcriptional repressors

    • Principal Investigator
      JOH Takashi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  Functional analysis of carboxy-terminal peptide signaling of pro-amphiregulin and pro-epiregulinPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Induction of lymphangiogenesis by membrane-binding growth factors

    • Principal Investigator
      HIRAKAWA Satoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Ehime University
  •  Membrane trafficking mechanism of HB-EGF from the plasma membrane to the nuclear membrane

    • Principal Investigator
      HIEDA Miki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
      Ehime University
  •  Isolation and Analysis of a transcriptional repressor to cause cardiac myopathy

    • Principal Investigator
      INOUE Hirofumi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Ehime University
  •  Functional analysis of the C-treminal frangment of membrane-anchored growth factorsPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Ehime University
  •  Carboxy-ternminal fragment signaling of membrane-anchored growth factors the EGF familyPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Nuclear translocation of cell-surface transmembrane growth factor HB-EGF

    • Principal Investigator
      HIEDA Miki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Ehime University
  •  膜蛋白質の核輸送を規定する因子の同定Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  Regulation of adhesion molecule integrins by membrane-bound proteinase ADAM

    • Principal Investigator
      MATSUURA Nariaki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Osaka University
  •  Radiation Effect on Invasion and Metastatic Potential of Cancer

    • Principal Investigator
      TESHIMA Teruki
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Osaka University
  •  EGFR ligands trafficking into the nucleus in gastric cancer cells

    • Principal Investigator
      JOH Takashi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  C-terminal fragment signaling of membrane-anchored growth factor HB-EGFPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Ehime University
  •  血管新生阻害物質の作用メカニズムの検討

    • Principal Investigator
      松浦 成昭
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
  •  The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric epithelial cells ; ADAM10 mediates IL-8-induced EGFR transactivation

    • Principal Investigator
      SASAKI Makoto, 横山 善文
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Nagoya City University
  •  膜結合型増殖因子と細胞間接着因子による細胞増殖および浸潤制御

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  海洋生物由来の細胞接着阻害物質による癌治療への応用

    • Principal Investigator
      松浦 成昭
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Osaka University
  •  膜結合型増殖因子と受容体型チロシンキナーゼを介したがん細胞の浸潤制御機構Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Ehime University
      Osaka University
  •  Physiological early response in tissue repair and regeneration -molecular mechanism of shedding : Analyses in wound healing modelPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Ehime University
      Osaka University
  •  Roles of EGF family molecules during early morphogenetic processes of mouse embryonic submandibular epithelium

    • Principal Investigator
      NAKANISHI Yasuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Osaka University
  •  接着分子の糖鎖リモデリングの生物学的意義の検討

    • Principal Investigator
      MATSUURA Nariaki
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  接着分子の制御による癌転移の抑制

    • Principal Investigator
      松浦 成昭
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Osaka University
  •  Establishment of the method for gene therapy of β cell regeneration by non-invasive gene delivery via pancreatic duct

    • Principal Investigator
      MIYAGAWA Jun-ichiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Endocrinology
    • Research Institution
      Osaka University
  •  肝細胞増殖因子受容体(c-Met)を介するシグナル伝達の分子機構

    • Principal Investigator
      喜多村 直実 (喜多村 直美)
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Institute of Technology
  •  ErbB2を介する腫瘍の悪性形質獲得の分子機構-新規ErbB2活性化リガンドNTAKとneuregulin-4によるシグナル伝達経路-Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  創傷治癒におけるHB-EGFの膜結合型と遊離型の機能解析(JAK-STATシグナル伝達系との関連について)

    • Principal Investigator
      SHIRAKATA Yuji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Ehime University
  •  Membrane-anchored growth factor shedding in tissue regeneration and repairePrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  Analysis of β cell differentiation in diabetic pancreas induced by betacellulin with special reference to the role of Pax family gene

    • Principal Investigator
      MIYAGAWA Jun-ichiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      Osaka University
  •  Redox regulation by glutathione and the roles of reactive oxygen and nitrogen species

    • Principal Investigator
      TANIGUCHI Naoyuki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  RESEARCH FOR ARTIFICIAL SKIN MASS PRODUCTION SYSTEM INTEGURATED WITH FOREIGN GENE

    • Principal Investigator
      HISHIMOTO Koji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      EHIME UNIVERSITY
  •  Application of integrin α4β1 for diagnosis and therapy of bone metastasis

    • Principal Investigator
      MATSUURA Nariaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Osaka University
  •  Molecular mechanisms of phenotypic modulation and growth of smooth muscle cells

    • Principal Investigator
      NAGAI Ryozo
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      University of Tokyo
      Gunma University
  •  The expression and the role of autocrine growth factors in differentiation of epidermal keratinocytes

    • Principal Investigator
      HIGASHIYAMA Mari
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Osaka University
  •  Studies on the beta cell differentiation signal in AR42J cells and in vivo effect on islet neogenesis in diabetic mice by betacellulin

    • Principal Investigator
      MIYAGAWA Jun-ichiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Osaka University
  •  Remodeling of regulation of cell growth by glycogene and its application.

    • Principal Investigator
      FUJII Junichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka University
  •  Characterization of a novel ligand for Receptor Tyrosine Kinase ErbBPrincipal Investigator

    • Principal Investigator
      HIGASHIYAMA Shigeki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka University
  •  膜アンカー型細胞増殖因子のジャクスタクリン/パラクリン変換の分子機構Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka University
  •  The genes encoding growth cone repulsive molecules

    • Principal Investigator
      FURUYAMA Shinobu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Osaka University
  •  Regulation of Cellular Activity by Reactive Oxygen

    • Principal Investigator
      TANIGUCHI Naoyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka University
  •  膜アンカー型細胞増殖因子の変換機構の解析Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka University
  •  ジャクスタクリン機構を介した細胞膜結合型細胞増殖因子と癌細胞増殖Principal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  新しい細胞増殖因子(BTC,HB-EGF)による膵β細胞分化増殖作用の研究

    • Principal Investigator
      MIYAGAWA Jun-ichiro
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Osaka University
  •  細胞膜結合型増殖因子変換酵素,セクレターゼの遺伝子発現クローニングPrincipal Investigator

    • Principal Investigator
      東山 繁樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka University
  •  Juxtacrine stimulation of cellular communication by HB-EGF.

    • Principal Investigator
      MEKADA Eisuke
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kurume University
  •  腫瘍マーカーとしてのMn-スーパーオキサイドディスムターゼの癌化による発現機構

    • Principal Investigator
      FUJII Junichi, TANIGUCHI Naoyuki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 細胞増殖因子と再生医療2006

    • Author(s)
      松本邦夫, 田畑泰彦, 東山繁樹 他
    • Total Pages
      401
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Book] 細胞増殖因子と再生医療2006

    • Author(s)
      松本邦夫, 田畑恭彦, 東山繁樹 他
    • Total Pages
      401
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Book] 細胞増殖因子と再生医療2006

    • Author(s)
      松本邦夫, 田畑泰彦, 東山繁樹 他
    • Total Pages
      401
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] PSMA‐positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state2021

    • Author(s)
      Watanabe Ryuta、Maekawa Masashi、Kiyoi Takeshi、Kurata Mie、Miura Noriyoshi、Kikugawa Tadahiko、Higashiyama Shigeki、Saika Takashi
    • Journal Title

      The Prostate

      Volume: 81 Issue: 16 Pages: 1390-1401

    • DOI

      10.1002/pros.24237

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09427
  • [Journal Article] CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP2021

    • Author(s)
      Nishiyama Kanako、Maekawa Masashi、Nakagita Tomoya、Nakayama Jun、Kiyoi Takeshi、Chosei Mami、Murakami Akari、Kamei Yoshiaki、Takeda Hiroyuki、Takada Yasutsugu、Higashiyama Shigeki
    • Journal Title

      Life Science Alliance

      Volume: 4 Issue: 9 Pages: e202101095-e202101095

    • DOI

      10.26508/lsa.202101095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K18029, KAKENHI-PROJECT-19K18030, KAKENHI-PUBLICLY-21H00286, KAKENHI-PROJECT-21H02763, KAKENHI-PROJECT-20K05709
  • [Journal Article] SPOP is essential for DNA-protein crosslink repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.2020

    • Author(s)
      Watanabe R, Maekawa M, Hieda M, Taguchi T, Miura N, Kikugawa T, Saika T, Higashiyama S.
    • Journal Title

      Mol Biol Cell

      Volume: 31 Issue: 6 Pages: 478-490

    • DOI

      10.1091/mbc.e19-08-0456

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06226, KAKENHI-PROJECT-19K18613, KAKENHI-PROJECT-18K09137
  • [Journal Article] Development of Human CBF1-Targeting Single-Stranded DNA Aptamers with Antiangiogenic Activity In Vitro2020

    • Author(s)
      Tezuka-Kagajo Mari、Maekawa Masashi、Ogawa Atsushi、Hatta Yoshiko、Ishii Eiichi、Eguchi Mariko、Higashiyama Shigeki
    • Journal Title

      Nucleic Acid Therapeutics

      Volume: 30 Issue: 6 Pages: 365-378

    • DOI

      10.1089/nat.2020.0875

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08866, KAKENHI-PROJECT-19K22564, KAKENHI-PROJECT-18K15718
  • [Journal Article] SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.2020

    • Author(s)
      Watanabe R, Kikugawa T, Saika T, Higashiyama S, et al.
    • Journal Title

      Molecular Biology of the Cell

      Volume: 31 Issue: 8 Pages: 478-490

    • DOI

      10.1091/mbc.

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11142
  • [Journal Article] SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.2019

    • Author(s)
      Tanigawa K, Maekawa M, Kiyoi T, Nakayama J, Kitazawa R, Kitazawa S, Semba K, Taguchi T, Akita S, Yoshida M, Ishimaru K, Watanabe Y, Higashiyama S.
    • Journal Title

      J Cell Physiol.

      Volume: in press Issue: 10 Pages: 17280-17294

    • DOI

      10.1002/jcp.28346

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15244, KAKENHI-PROJECT-16H04698, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-18K16317
  • [Journal Article] Cullin‐3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2‐positive breast cancer cells2019

    • Author(s)
      Murakami Akari、Maekawa Masashi、Kawai Katsuhisa、Nakayama Jun、Araki Nobukazu、Semba Kentaro、Taguchi Tomohiko、Kamei Yoshiaki、Takada Yasutsugu、Higashiyama Shigeki
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 2 Pages: 650-661

    • DOI

      10.1111/cas.13899

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06831, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-17K16510, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05903
  • [Journal Article] Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin2018

    • Author(s)
      Nakayama Hironao、Sakaue Tomohisa、Maekawa Masashi、Fujisaki Ayako、Higashiyama Shigeki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 499 Issue: 1 Pages: 17-23

    • DOI

      10.1016/j.bbrc.2018.03.097

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K15221, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013, KAKENHI-PROJECT-18K07234, KAKENHI-PROJECT-16H04698
  • [Journal Article] The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB2018

    • Author(s)
      Kovacevic Igor、Sakaue Tomohisa、Majolee Jisca、Pronk Manon C.、Maekawa Masashi、Geerts Dirk、Fernandez-Borja Mar、Higashiyama Shigeki、Hordijk Peter L.
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Issue: 3 Pages: 1015-1032

    • DOI

      10.1083/jcb.201606055

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-18K07234
  • [Journal Article] Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen2018

    • Author(s)
      Sakaue Tomohisa、Nakaoka Hirotomo、Shikata Fumiaki、Aono Jun、Kurata Mie、Uetani Teruyoshi、Hamaguchi Mika、Kojima Ai、Uchita Shunji、Yasugi Takumi、Higashi Haruhiko、Suzuki Jun、Ikeda Shuntaro、Higaki Jitsuo、Higashiyama Shigeki、Izutani Hironori
    • Journal Title

      Biology Open

      Volume: 7 Issue: 8

    • DOI

      10.1242/bio.034009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10631, KAKENHI-PROJECT-16H04698
  • [Journal Article] The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells2017

    • Author(s)
      Sakaue T, Sakakibara I, Fujisaki A, Uesugi T, Nakashiro K, Hamakawa H, Kubota E, Joh T, Imai Y, Izutani H, Higashiyama S.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 42845-42845

    • DOI

      10.1038/srep42845

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04961, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K15552, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-17K09357
  • [Journal Article] Glutamate-Dependent Ectodomain Shedding of Neuregulin-1 Type II Precursors in Rat Forebrain Neurons.2017

    • Author(s)
      1)Iwakura Y, Wang R, Inamura N, Araki K, Higashiyama S, Takei N, Nawa N
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: e0174780-e0174780

    • DOI

      10.1371/journal.pone.0174780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07053, KAKENHI-PROJECT-16K15221
  • [Journal Article] Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis2017

    • Author(s)
      Sakaue Tomohisa、Maekawa Masashi、Nakayama Hironao、Higashiyama Shigeki
    • Journal Title

      The Journal of Biochemistry

      Volume: 162 Pages: 237-245

    • DOI

      10.1093/jb/mvx051

    • NAID

      40021380486

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013
  • [Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017

    • Author(s)
      Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
    • Journal Title

      Biolology Open

      Volume: 6 Pages: 1707-1719

    • DOI

      10.1242/bio.029579

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
  • [Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017

    • Author(s)
      Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 2 Pages: 208-215

    • DOI

      10.1111/cas.13133

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
  • [Journal Article] Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) is induced by VEGF-A.2016

    • Author(s)
      Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 20 Pages: 10490-10490

    • DOI

      10.1074/jbc.m115.683201

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08308, KAKENHI-PROJECT-16K15221
  • [Journal Article] Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.2016

    • Author(s)
      Fukuda S, Nishida-Fukuda H, Nanba D, Nakashiro K, Nakayama H, Kubota H, Higashiyama S.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 20209-20209

    • DOI

      10.1038/srep20209

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08308, KAKENHI-PROJECT-26461660, KAKENHI-PROJECT-26670143
  • [Journal Article] Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability2016

    • Author(s)
      Hiraoka C, Toki F, Shiraishi K, Sayama K, Nishimura EK, Miura H, Higashiyama S, Nanba D
    • Journal Title

      Journal of Dermatological Science

      Volume: 82 Issue: 2 Pages: 84-94

    • DOI

      10.1016/j.jdermsci.2016.01.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461660, KAKENHI-PROJECT-26670143
  • [Journal Article] Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes.2016

    • Author(s)
      Groth E, Pruessmeyer J, Babendreyer A, Schumacher J, Pasqualon T, Dreymueller D, Higashiyama S, Lorenzen I, Grotzinger J, Cataldo D, Ludwig A.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1863 Issue: 11 Pages: 2795-2808

    • DOI

      10.1016/j.bbamcr.2016.09.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15221
  • [Journal Article] Cell motion predicts human epidermal stemness.2015

    • Author(s)
      Nanba D, Toki F, Tate S, Imai M, Matsushita N, Shiraishi K, Sayama K, Toki H, Higashiyama S, Barrandon Y.
    • Journal Title

      J Cell Biol.

      Volume: 209 Issue: 2 Pages: 305-315

    • DOI

      10.1083/jcb.201409024

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390074, KAKENHI-PUBLICLY-25112712, KAKENHI-PROJECT-26461660, KAKENHI-PROJECT-26670143, KAKENHI-PROJECT-25293245
  • [Journal Article] Long-term exposure to leptin enhances the growth of prostate cancer cells2015

    • Author(s)
      Noda T, Kikugawa T, Tanji N, Miura N, Asai S, Higashiyama S, Yokoyama M.
    • Journal Title

      Int J Oncol.

      Volume: 46 Issue: 4 Pages: 1535-1542

    • DOI

      10.3892/ijo.2015.2845

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Journal Article] Rotation is the primary motion of paired human epidermal keratinocytes2015

    • Author(s)
      Tate S, Imai M, Matsushita N, NIshimura EK, Higashiyama S, Nanba D
    • Journal Title

      Journal of Dermatological Science

      Volume: 79 Issue: 3 Pages: 194-202

    • DOI

      10.1016/j.jdermsci.2015.05.008

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461660, KAKENHI-PROJECT-26670143
  • [Journal Article] High-throughput synthesis of stable isotope-labeled transmembrane proteins for targeted transmembrane proteomics using a wheat germ cell-free protein synthesis system.2015

    • Author(s)
      Takemori N, Takemori A, Matsuoka K, Morishita R, Matsushita N, Aoshima M, Takeda H, Sawasaki T, Endo Y, Higashiyama S.
    • Journal Title

      Mol Biosyst.

      Volume: 11 Issue: 2 Pages: 361-365

    • DOI

      10.1039/c4mb00556b

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25112712, KAKENHI-PUBLICLY-25117719, KAKENHI-PROJECT-25290077, KAKENHI-PROJECT-26640130
  • [Journal Article] Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.2014

    • Author(s)
      Shirato A, Kikugawa T, Miura N, Tanji N, Takemori N, Higashiyama S, Yokoyama M.
    • Journal Title

      Oncol Lett.

      Volume: 7 Pages: 674-678

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Journal Article] Pathophysiology of lung injury induced by common bile duct ligation in mice2014

    • Author(s)
      Shikata F, Sakaue T, Nakashiro K, Okazaki M, Okamura T, Okura M, Ryugo M, Nakamura Y, Yasugi T, Higashiyama S, Izutani H
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 4 Pages: e94550-e94550

    • DOI

      10.1371/journal.pone.0094550

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390457, KAKENHI-PUBLICLY-25112712
  • [Journal Article] ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.2014

    • Author(s)
      Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 307 Issue: 5 Pages: F551-F559

    • DOI

      10.1152/ajprenal.00218.2014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390074, KAKENHI-PUBLICLY-25112712, KAKENHI-PROJECT-26670143
  • [Journal Article] Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells2014

    • Author(s)
      Shirato A, Kikugawa T, Miura N, Tanji N, Takemori N, Higashiyama S, Yokoyama M.
    • Journal Title

      Oncol Lett

      Volume: 7 Pages: 674-678

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24527071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Journal Article] Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage2014

    • Author(s)
      Taira N, Yamaguchi T, Kimura J, Lu Z-G, Fukuda S, Higashiyama S, Ono M, Yoshida K
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 111 Issue: 2 Pages: 717-722

    • DOI

      10.1073/pnas.1313675111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300347, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382, KAKENHI-PUBLICLY-25112712, KAKENHI-PROJECT-25640080, KAKENHI-PROJECT-26290041, KAKENHI-PROJECT-26670143
  • [Journal Article] Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.2014

    • Author(s)
      Shirato A, Kikugawa T, Miura N, Tanji N, Takemori N, Higashiyama S, Yokoyama M.
    • Journal Title

      Oncol Lett.

      Volume: 7 Pages: 674-678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Journal Article] Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-α in monocytes and colon epithelial cells.2013

    • Author(s)
      Hironobu Tsukamoto, Satoshi Tanida, Keiji Ozeki, Shigeki Higashiyama, and Takashi Joh
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590949
  • [Journal Article] Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.2013

    • Author(s)
      Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.
    • Journal Title

      J Cell Biol.

      Volume: 201 Pages: 279-292

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Journal Article] ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cell lines; re-evaluation of their low-affinity interaction.2013

    • Author(s)
      Wang, R., Iwakura, Y., Araki, K., Keino-Masu, K., Masu, M., Wang, X., Takei, N., Higashiyama, S. and Nawa, H.
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 1402-1402

    • DOI

      10.1038/srep01402

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22123006, KAKENHI-PROJECT-22500284, KAKENHI-PUBLICLY-24110502, KAKENHI-PROJECT-25293065, KAKENHI-PROJECT-25430064, KAKENHI-PUBLICLY-23112513, KAKENHI-PLANNED-24116010
  • [Journal Article] Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.2013

    • Author(s)
      Miwa D, Sakaue T, Inoue H, Takemori N, Kurokawa M, Fukuda S, Omi K, Goishi K, Higashiyama S.
    • Journal Title

      Angiogenesis.

      Volume: 16 Issue: 3 Pages: 675-88

    • DOI

      10.1007/s10456-013-9345-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590382, KAKENHI-PUBLICLY-25112712
  • [Journal Article] Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells.2013

    • Author(s)
      Ozeki K, Tanida S, Morimoto C, Inoue Y, Mizoshita T, Tsukamoto H, Shimura T, Kataoka H, Kamiya T, Nishiwaki E, Ishiguro H, Higashiyama S, Joh T.
    • Journal Title

      PLoS One

      Volume: 8(2) Issue: 2 Pages: e56770-e56770

    • DOI

      10.1371/journal.pone.0056770

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579940/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590704, KAKENHI-PROJECT-23790802, KAKENHI-PROJECT-24590923, KAKENHI-PROJECT-24659280
  • [Journal Article] Annexin A2 regulates a disintegrin and metalloproteinase 17-mediated ectodomain shedding of pro-tumor necrosis factor-α in monocytes and colon epithelial cells.2013

    • Author(s)
      Tsukamoto H, Tanida S, Ozeki K, Ebi M, Mizoshita T, Shimura T, Mori Y, Kataoka H, Kamiya T, Fukuda S, Higashiyama S, Joh T.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 19 Issue: 7 Pages: 1365-1373

    • DOI

      10.1097/mib.0b013e318281f43a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24590923, KAKENHI-PROJECT-24590949, KAKENHI-PROJECT-24659280
  • [Journal Article] Involvement of NANOG upregulation in malignant progression of human cells.2013

    • Author(s)
      Li Y., Higashiyama S., Shimakage M., Kawahara K., Yutsudo M., Watari A.
    • Journal Title

      DNA Cell Biol.

      Volume: 32(3) Issue: 3 Pages: 104-10

    • DOI

      10.1089/dna.2012.1908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790155, KAKENHI-PUBLICLY-23112513
  • [Journal Article] Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells2013

    • Author(s)
      Ota I, Higashiyama S, Masui T, et al.
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 4 Pages: 1593-1600

    • DOI

      10.3892/or.2013.2659

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592537, KAKENHI-PROJECT-24390074
  • [Journal Article] Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes.2013

    • Author(s)
      Nakayama H, Fukuda S, Matsushita N, Nishida-Fukuda H, Inoue H, Shirakata Y, Hashimoto K, Higashiyama S.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 15 Pages: 10338-48

    • DOI

      10.1074/jbc.m112.417527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24591655, KAKENHI-PROJECT-24659280
  • [Journal Article] Spatiotemporal visualisation of proHB-EGF ectodomain shedding in living cells2013

    • Author(s)
      H. Inoue, T. Sakaue, T. Ozawa and S. Higashiyama
    • Journal Title

      J. Biochem.

      Volume: 154 Issue: 1 Pages: 67-76

    • DOI

      10.1093/jb/mvt030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21675001, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24659280
  • [Journal Article] Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia2013

    • Author(s)
      Díaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge SA.
    • Journal Title

      J Cell Biol

      Volume: 201 Issue: 2 Pages: 279-292

    • DOI

      10.1083/jcb.201209151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280, KAKENHI-PUBLICLY-25112712
  • [Journal Article] Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes.2013

    • Author(s)
      Kurokawa M, Ise N, Omi K, Goishi K, Higashiyama S.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 7 Pages: 904-911

    • DOI

      10.1111/cas.12171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280, KAKENHI-PUBLICLY-25112712, KAKENHI-PUBLICLY-23112513
  • [Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.2013

    • Author(s)
      Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 437 Issue: 2 Pages: 185-191

    • DOI

      10.1016/j.bbrc.2013.05.097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972, KAKENHI-PROJECT-24590975
  • [Journal Article] Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.2013

    • Author(s)
      Miwa D, Inoue H, Takemori N, Kurokawa M, Sakaue T, Fukuda S, Omi K, Goishi K, Higashiyama S.
    • Journal Title

      Angiogenesis

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23112513
  • [Journal Article] Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.2013

    • Author(s)
      Miwa D, Inoue H, Takemori N, Kurokawa M, Sakaue T, Fukuda S, Omi K, Goishi K, Higashiyama S.
    • Journal Title

      Angiogenesis

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Journal Article] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signalling in angiogenesis2012

    • Author(s)
      Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, and Higashiyama S
    • Journal Title

      Blood

      Volume: 119 Issue: 11 Pages: 2688-2698

    • DOI

      10.1182/blood-2011-03-345306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428, KAKENHI-PUBLICLY-23112513
  • [Journal Article] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis2012

    • Author(s)
      Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, Higashiyama S
    • Journal Title

      Blood

      Volume: 119 Pages: 2688-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23112513
  • [Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of pro-amphiregulin2012

    • Author(s)
      Hironao Nakayama
    • Journal Title

      Molecular Biology of the Cell

      Volume: (印刷中) Issue: 10 Pages: 1964-1975

    • DOI

      10.1091/mbc.e11-08-0683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790319, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24591628, KAKENHI-PROJECT-24591655, KAKENHI-PROJECT-24659280, KAKENHI-PUBLICLY-23112513
  • [Journal Article] TGFα shedding assay: an accurate and versatile method for detecting GPCR activation.2012

    • Author(s)
      Asuka Inoue
    • Journal Title

      Nat Methods

      Volume: 9 Issue: 10 Pages: 1021-1029

    • DOI

      10.1038/nmeth.2172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659025, KAKENHI-PROJECT-24659280, KAKENHI-PROJECT-24790064, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PUBLICLY-23112513
  • [Journal Article] A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.2012

    • Author(s)
      Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M.
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Journal Article] Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF growth factor domain independent manner2012

    • Author(s)
      Tanaka H, Nishioka Y, Yokoyama Y, Higashiyama S, Matsuura N, Matsuura S, Hieda M.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin2012

    • Author(s)
      Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashiyama S
    • Journal Title

      Mol.Biol.Cell

      Volume: (未定)(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin2012

    • Author(s)
      Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashiyama S.
    • Journal Title

      Mol. Biol. Cell

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer2012

    • Author(s)
      Yoshida Michihiro
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 4 Pages: 708-715

    • DOI

      10.1111/j.1349-7006.2012.02204.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790319, KAKENHI-PROJECT-22790665, KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24590923, KAKENHI-PUBLICLY-23112513
  • [Journal Article] A disintegrin and metalloenzyme (ADAM) 17 activation is regulated byα5β1 integrin in kidney mesangial cells2012

    • Author(s)
      Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 3 Pages: e33350-e33350

    • DOI

      10.1371/journal.pone.0033350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659280, KAKENHI-PUBLICLY-23112513
  • [Journal Article] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding2012

    • Author(s)
      Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 420 Pages: 315-320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer2012

    • Author(s)
      Yoshida M, Shimura T, Fukuda S, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Nakazawa T, Higashiyama S, Joh T.
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 708-715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells2012

    • Author(s)
      Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] A Disintegrin and Metalloenzyme(ADAM) 17 Activation Is Regulated byα5β1 Integrin in Kidney Mesangial Cells2012

    • Author(s)
      Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M.
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding2012

    • Author(s)
      Shinji Fukuda
    • Journal Title

      Biochemical and Biophysical Research Communication

      Volume: 420 Issue: 2 Pages: 315-320

    • DOI

      10.1016/j.bbrc.2012.02.156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790319, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382
  • [Journal Article] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding2012

    • Author(s)
      Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Pages: 315-320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion2012

    • Author(s)
      Shimura T, Yoshida M, Fukuda S, Ebi M, Hirata Y, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      BMC Cancer

      Volume: 12 Issue: 1 Pages: 205-205

    • DOI

      10.1186/1471-2407-12-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24590923
  • [Journal Article] Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF growth factor domain independent manner2012

    • Author(s)
      Tanaka H, Nishioka Y, Yokoyama Y, Higashiyama S, Matsuura N, Matsuura S, Hieda M
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: (未定)(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands2011

    • Author(s)
      Higashiyama S, Nanba D, Nakayama H, Inoue H, Fukuda S.
    • Journal Title

      J. Biochem

      Volume: 150 Pages: 15-22

    • NAID

      10030586134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] HB-EGF-C末端核移行シグナルをターゲットにした新規薬剤探索と細胞増殖抑制機序2011

    • Author(s)
      尾関啓司, 谷田諭史, 溝下勤, 水島隆史, 志村貴也, 村上賢治, 平田慶和, 片岡洋望, 神谷武, 福田伸治, 東山繁樹, 城卓志
    • Journal Title

      消化器と免疫

      Volume: 47 Pages: 144-146

    • Data Source
      KAKENHI-PROJECT-21590790
  • [Journal Article] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro2011

    • Author(s)
      Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci

      Volume: 51 Pages: 630-639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] HB-EGF-C末端核移行シグナルをターゲットにした新規薬剤探索と細胞増殖抑制機序2011

    • Author(s)
      尾関啓司,谷田諭史,溝下 勤,水島隆史,志村貴也,村上賢治,平田慶和,片岡洋望,神谷 武,福田伸治,東山繁樹,城 卓志
    • Journal Title

      消化器と免疫

      Volume: 47 Pages: 144-146

    • Data Source
      KAKENHI-PROJECT-22590704
  • [Journal Article] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.2011

    • Author(s)
      Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ.
    • Journal Title

      Wound Repair Regen

      Volume: 19 Pages: 229-240

    • NAID

      10031181736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.2011

    • Author(s)
      Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ.
    • Journal Title

      Wound Repair Regen

      Volume: 19 Pages: 229-240

    • NAID

      10031181736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts2011

    • Author(s)
      Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ.
    • Journal Title

      Wound Repair Regen

      Volume: 19 Pages: 229-240

    • NAID

      10031181736

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Insulin-Induced Ectodomain Shedding of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Adipocytes In Vitro.2010

    • Author(s)
      Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y.
    • Journal Title

      Obesity (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line2010

    • Author(s)
      Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.
    • Journal Title

      Int J Mol Med. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.2010

    • Author(s)
      Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 402 Pages: 449-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Insulin-Induced Ectodomain Shedding of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Adipocytes In Vitro2010

    • Author(s)
      Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y.
    • Journal Title

      Obesity (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors.Laboratory investigation.2010

    • Author(s)
      Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka J, Higashiyama S, Saito N, Kirino T, Kawahara N.
    • Journal Title

      J Neurosurg.

      Volume: 113 Pages: 835-850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Novel monoclonal antibodies recognizing the active conformation of epidermal growth factor receptor.2010

    • Author(s)
      Ise N, Omi K, Miwa K, Honda H, Higashiyama S, Goishi K.
    • Journal Title

      Biochem Biophys Res Commun. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.2010

    • Author(s)
      Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 630-639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro2010

    • Author(s)
      Yamamoto T, Suganami T, Kiso-Narita M, Scherle PA, Kamei Y, Isobe M, Higashiyama S, Ogawa Y.
    • Journal Title

      Obesity

      Volume: 18 Pages: 1888-1894

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] TGFβinduces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells2010

    • Author(s)
      Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 1402 Pages: 449-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells.2010

    • Author(s)
      Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 402 Pages: 449-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.2010

    • Author(s)
      Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 630-639

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Journal Article] TGFβinduces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancercells2010

    • Author(s)
      Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 402(3) Issue: 3 Pages: 449-54

    • DOI

      10.1016/j.bbrc.2010.09.130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590790, KAKENHI-PROJECT-22590704
  • [Journal Article] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors.2010

    • Author(s)
      Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N.
    • Journal Title

      J Neurosurg. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Induction of striatal neurogenesis and generation of region-specific functional mature neurons after ischemia by growth factors2010

    • Author(s)
      Yoshikawa G, Momiyama T, Oya S, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N.
    • Journal Title

      J Neurosung (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.2010

    • Author(s)
      Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.
    • Journal Title

      Int J Mol Med. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.2009

    • Author(s)
      Schirrmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Iaumann M, Lendeckel U.
    • Journal Title

      Exp Cell Res. 315

      Pages: 3500-3508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.2009

    • Author(s)
      Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW
    • Journal Title

      Mol Biol Cell. 24

      Pages: 5236-5249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cansers2009

    • Author(s)
      Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      BrJCancer 100

      Pages: 1320-1329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity2009

    • Author(s)
      Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR
    • Journal Title

      Immunity 30

      Pages: 802-816

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.2009

    • Author(s)
      Myers TJ, Higashiyama S
    • Journal Title

      Mol Biol Cell. 20(24)

      Pages: 5236-49

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling.2009

    • Author(s)
      Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A
    • Journal Title

      Mol Membr Biol. 5

      Pages: 279-792

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.2009

    • Author(s)
      Xu D, Higashiyama S
    • Journal Title

      Immunity 30(6)

      Pages: 802-16

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling2009

    • Author(s)
      Grossmann S, Higashiyama S, Oksche A, Schaefer M, Tannert A
    • Journal Title

      Mol Mernbr Biol. 5

      Pages: 279-792

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells.2009

    • Author(s)
      Akino Y, Teshima T, Kihara A, Kodera-Suzumoto Y, Inaoka M, Higashiyama S, Furusawa Y, Matsuura N
    • Journal Title

      Int J Radiat Oncol Biol Phys. 75

      Pages: 475-481

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Insufficiency of pro-heparin-binding epidermal growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via activation of caspase-3 and c-Jun N-terminal kinase2009

    • Author(s)
      Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S.
    • Journal Title

      J Biol Chem. 284

      Pages: 12399-12409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.2009

    • Author(s)
      Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S.
    • Journal Title

      J Biol Chem. 284

      Pages: 12399-12409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Insufficient shedding of proHB-EGF enhances hypoxic cell death in H9c2 cardiomyoblasts via activation of Caspase-3 and c-Jun N-terminal kinase2009

    • Author(s)
      Uetani, T., Nakayama, H., Okayama, H.,Okura T., Higaki, J., Inoue, H., &Higashiyama, S.
    • Journal Title

      J.Biol. Chem (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.2009

    • Author(s)
      Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K.
    • Journal Title

      Mol Cancer Res 9

      Pages: 1572-1581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.2009

    • Author(s)
      Oyagi A, Higashiyama S
    • Journal Title

      PLoS One. 4(10)

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Mitochondrial reactive oxygen Species mediate GPCR-induced TACE/ADAM17-dependent transforming growth-alpha shedding2009

    • Author(s)
      Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW
    • Journal Title

      Mol Biol Cell. 24

      Pages: 5236-5249

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation : involvement of PKC-delta and PKC-epsilon in the in the shedding of epidermal growth factor receptor ligands2009

    • Author(s)
      Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N
    • Journal Title

      Eur J Pharm Sci 38

      Pages: 504-511

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.2009

    • Author(s)
      Myers TJ, Higashiyama S
    • Journal Title

      Mol Biol Cell. 20

      Pages: 5236-5249

    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CAl region after ischemic injury2009

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N.
    • Journal Title

      Neuroscience 58

      Pages: 683-692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation : involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.2009

    • Author(s)
      Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N
    • Journal Title

      Eur J Pharm Sci. 38

      Pages: 504-511

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells2009

    • Author(s)
      Akino Y, Teshima T, Kihara A, Kodera-Suzumoto Y, Inaoka M, Higashiyama S, Furusawa Y, Matsuura N
    • Journal Title

      Int J Radiat Oncol Biol Phys 75

      Pages: 475-481

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] BCL6 degradation caused by the interation with the C-terminus of proHB-EGF induces cycline D2 expression in gastric cancers2009

    • Author(s)
      Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Mizoshita T, Shimura T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      British Journal of Cancer

      Volume: 100 Issue: 5 Pages: 1320-1329

    • DOI

      10.1016/s0016-5085(09)61447-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590790, KAKENHI-PROJECT-22590704
  • [Journal Article] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.2009

    • Author(s)
      Uetani T, Inoue H, Higashiyama S
    • Journal Title

      J Biol Chem. 284(18)

      Pages: 12399-409

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice2009

    • Author(s)
      Oyagi A, Oida Y, Kakefuda K, Shimarawa M, Shioda N, Moriguchi S, Kitaichi K, Nanba D, Yamaguchi K, Furuta Y, Fukunaga K, Higashiyama S, Hara H
    • Journal Title

      PLoS One 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Serine protease inhibitor Kazaltype 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor2009

    • Author(s)
      Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K.
    • Journal Title

      Mol Cancer Res 9

      Pages: 1572-1581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury2009

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N.
    • Journal Title

      Neuroscience 158

      Pages: 683-692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.2009

    • Author(s)
      Xu D, Higashiyama S
    • Journal Title

      Immunity. 30

      Pages: 802-816

    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection2009

    • Author(s)
      Schimmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Naumann M, Lendeckel U.
    • Journal Title

      Exp Cell Res 315

      Pages: 3500-3508

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.2009

    • Author(s)
      Oyagi A, Oida Y, Kakefuda K, Shimazawa M, Shioda N, Moriguchi S, Kitaichi K, Nanba D, Yamaguchi K, Furuta Y, Fukunaga K, Higashiyama S, Hara H
    • Journal Title

      PLoS One 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.2009

    • Author(s)
      Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR
    • Journal Title

      Immunity. 30

      Pages: 802-816

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers.2009

    • Author(s)
      Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, Mori Y, Kubota E, Wada T, Tanida S, Kataoka H, Kamiya T, Higashiyama S, Joh T
    • Journal Title

      Br J Cancer. 100

      Pages: 1320-1329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury.2009

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI, Higashiyama S, Saito N, Kirino T, Kawahara N.
    • Journal Title

      Neuroscience. 58

      Pages: 683-692

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer2008

    • Author(s)
      Ezumi, K., Yamamoto, H., Murata, K.,Higashiyama, M., Damdinsuren, B.,Nakamura, Y., Kyo, N., Okami, J., Ngan,C.Y., Takemasa, I., Ikeda, M., Sekimoto,M., Matsuura, N., Nojima, H., Monden, M.
    • Journal Title

      Clin. Cancer Res 14

      Pages: 677-684

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Membrane-anchored growth factors,the EGF family.Beyond receptor lig ands2008

    • Author(s)
      Higashiyama, et. al.
    • Journal Title

      Cancer Science 99

      Pages: 214-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Membrane-anchored growth factor,HB-EGF, on the cell surface targeted to the inner nuclear membrane2008

    • Author(s)
      Hieda, M., Isokane, M., Koizumi, M.,Higashi, C., Tachibana, T., Shudou, M.,Taguchi, T., Hieda, Y., and Higashiyama, S.
    • Journal Title

      J. Cell Biol 180

      Pages: 763-769

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Membrane-anchored Growth Factors, The EGF Family : Beyond receptor ligands2008

    • Author(s)
      Higashiyama, S., Iwabuki, H., Morimoto,C., Hieda, M., Inoue, H., and Matsushita, N.
    • Journal Title

      Cancer Sci 99

      Pages: 214-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Region-specific proliferative response of neural progenitors to exogenous stimulation by growth factors following ischemia2008

    • Author(s)
      Oya S, Yoshikawa G, Takai K, Tanaka JI,Higashiyama, S., Saito N, Kirino T,Kawahara N.
    • Journal Title

      Neuroreport 19

      Pages: 805-809

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] The plasma membrane-anchored growth factor, pro-amphiregulin, binds A-type lamin and regulates global transcription2008

    • Author(s)
      Isokane, M., Hieda, M., Hirakawa, S.,Shudou, M., Nakashiro, K., Hashimoto, K., Hamakawa, H., and Higashiyama, S.
    • Journal Title

      J. Cell. Sci 121

      Pages: 3608-3618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.2008

    • Author(s)
      Isokane M, Hieda M, Hirakawa S, Shudou M, Nakashiro K, Hashimoto K, Hamakawa H, Higashiyama S.
    • Journal Title

      J Cell Sci. 121

      Pages: 3608-3618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591348
  • [Journal Article] Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.2008

    • Author(s)
      Hieda M, Higashiyama S
    • Journal Title

      J Cell Biol. 180(4)

      Pages: 763-9

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.2008

    • Author(s)
      Nanba D, Inoue H, Higashiyama S
    • Journal Title

      J Cell Physiol. 214(2)

      Pages: 465-73

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.2008

    • Author(s)
      Higashiyama S
    • Journal Title

      Cancer Sci 99(2)

      Pages: 214-20

    • NAID

      10024001752

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.2008

    • Author(s)
      Isokane M, Hieda M, Higashiyama S.
    • Journal Title

      J Cell Sci. 121

      Pages: 3608-3618

    • Data Source
      KAKENHI-PROJECT-20390082
  • [Journal Article] Membrane-anchored growth factors, the EGF tamily. Beyond receptor ligands.2008

    • Author(s)
      Higashiyama, et al.
    • Journal Title

      Cancer Science 211

      Pages: 214-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription.2008

    • Author(s)
      Isokane M, Hieda M, Higashiyama S
    • Journal Title

      J Cell Sci. 121(Pt21)

      Pages: 3608-18

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Pbx1 is a major target of PLZF-mediated melanoma cell growth suppression.2007

    • Author(s)
      Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Oncogene 26

      Pages: 339-348

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Pbx1is a major target of PLZF-mediated melanoma cell growth suppression2007

    • Author(s)
      Shiraishi, K., Yamasaki, K., Nanba, D.,Inoue, H., Hanakawa, Y., Shirakata, Y.,Hashimoto, K., and Higashiyama, S.
    • Journal Title

      Oncogene 26

      Pages: 339-348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts2007

    • Author(s)
      Furochi, H., Tamura, S., Mameoka, M.,Yamada, C., Ogawa, T., Hirasaka, K.,Okumura, Y., Imagawa, T., Oguri, S.,Ishidoh, K., Kishi, K., Higashiyama, S.Nikawa, T.
    • Journal Title

      FEBS Lett 581

      Pages: 5743-5750

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] The carboxy-terminal fragment of proHB-EGF reverses Bc16-mediated gene repression2007

    • Author(s)
      Y.Kinugasa, M.Hieda, M.Hori, S.Higashiyama
    • Journal Title

      The Journal of Biological Chemistry (In press)

    • Data Source
      KAKENHI-PROJECT-17570163
  • [Journal Article] Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding2007

    • Author(s)
      Ikin, A.F., Causevic, M., Pedrini, S.,Lyndsey S. Bensonl, L.S., Buxbaum, J.D.,Suzuki, T., Simon Lovestone, S.,Higashiyama, S., Mustelin, T., Burgoyne, R.D., and Gandy, S.
    • Journal Title

      Molecular Neurodegeneration 2, 23

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] The carboxy-terminal fragment of proHB-EGF reverses Bcl6-mediated gene repression2007

    • Author(s)
      Y.Kinugasa, M.Hieda, M.Hori, S.Higashiyama
    • Journal Title

      The Journal of Biological Chemistry (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570163
  • [Journal Article] Pbx1is a major target of PLZF-mediated melanoma cell growth suppression.2007

    • Author(s)
      Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Oncogene 26

      Pages: 339-348

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] The carboxy-terminal fragment of proHB-EGF reverses Bcl6-mediated gene expression.2007

    • Author(s)
      Kinugasa, Y., Hieda, M., Hori, M., Higashiyama, S.
    • Journal Title

      J. Biol. Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] An intermediary role of proHB-EGF shedding in growth factor-induced c-myc expression2007

    • Author(s)
      Nanba, D., Inoue, Y., Shigemi, Y., Shirakata, Y., Hashimoto, K., and Higashiyama, S.
    • Journal Title

      J.Cell.Physiol 214

      Pages: 465-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members2007

    • Author(s)
      Morita, S., Shirakata, Y., Shiraishi, A.Kadota, Y., Hashimoto , K., Higashiyama,S., Ohashi, Y.
    • Journal Title

      Mol. Vision 13

      Pages: 2119-2128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.2007

    • Author(s)
      Shiraishi K, Inoue H, Higashiyama S
    • Journal Title

      Oncogene 26(3)

      Pages: 339-48

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] he carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression.2007

    • Author(s)
      Kinugasa Y, Hieda M, Hori M, Higashiyama S
    • Journal Title

      J Biol Chem. 282(20)

      Pages: 14797-806

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] The carboxyl-terminal fragment of proHB-EGF reverses Bcl6-mediated gene repression2007

    • Author(s)
      Kinugasa, Y., Hieda, M., Hori, M., and Higashiyama, S.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 14797-14806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Journal Article] Pbxl is a major target of PLZF-mediated melanoma cell growth suppression.2007

    • Author(s)
      Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Oncogene 26

      Pages: 339-348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Alternative recycling of E-cadeherin depends on metalloprotease activity of ADAM92006

    • Author(s)
      Hirao, F., Nanba, D., Tanaka, M., Ishiguro, H., Kinugasa, Y., Doki, Y., Yanao, M., Matuura, N., Monden, M., Higashiyama, S.
    • Journal Title

      Exp. Cell Res. 312

      Pages: 331-339

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.2006

    • Author(s)
      Kikugawa, T., Kinugasa, Y., Shiraishi, K., Nanba, D., Nakashiro K., Tanji, N., Yokoyama, M., Higashiyama, S.
    • Journal Title

      The Prostate 66

      Pages: 1092-2099

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart valve malformation and cardiac hypertrophy.2006

    • Author(s)
      Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamutra, H., Takahashi, K., Takakura, N., Mekada, E., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Biochem Biophys Res Commun. 350

      Pages: 315-321

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.2006

    • Author(s)
      Kikugawa T., Kinugasa Y., Shiraishi K., Nanba D., Nakashiro K., Tanji N., Yokoyama M., Higashiyama S.
    • Journal Title

      The Prostate 66

      Pages: 1092-2099

    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons.2006

    • Author(s)
      Shishido, Y., Tanaka, T., Piao, Y.S., Araki, K., Takei, N., Higashiyama, S., Nawa H.
    • Journal Title

      Biochem Biophys Res Commun. 348

      Pages: 963-970

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Alternative recycling of E-cadeherin depends on metalloprotease activity of ADAM92006

    • Author(s)
      Hirao, F., Nanba, D., Tanaka, M., Ishiguro, H., Kinugasa, Y., Doki, Y., Yanao, M., Matuura, N., Monden, M., Higashiyama, S.
    • Journal Title

      Exp.Cell Res. 312

      Pages: 331-339

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart valve malformation and cardiac hypertrophy.2006

    • Author(s)
      Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamutra, H., Takahashi, K., Takakura, N., Mekada, E., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Biochem Biophys Res Commun. 350

      Pages: 315-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] PLZF regulates Pbxl transcription and Pbxl-HoxC8 complex leads to androgen-independent prostate cancer proliferation.2006

    • Author(s)
      Kikugawa, T., Kinugasa, Y., Shiraishi, K., Nanba, D., Nakashiro K., Tanji, N., Yokoyama.M., Higashiyama.S.
    • Journal Title

      The Prostate 66

      Pages: 1092-2099

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] HB-EGF ad liver regeneration.2006

    • Author(s)
      Higashiyama, S., Kiso, S.
    • Journal Title

      Growth Factor & Regenerative Medicine

      Pages: 50-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons.2006

    • Author(s)
      Shishido, Y., Tanaka, T., Piao, Y.S., Araki, K., Takei, N., Higashiyama, S., Nawa H.
    • Journal Title

      Biochem Biophys Res Commun. 348,

      Pages: 963-970

    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart valve malformation and cardiac hypertrophy.2006

    • Author(s)
      Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamutra, H., Takahashi, K., Mekada, E., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Biochem Biophys Res Commun. 350

      Pages: 315-321

    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons.2006

    • Author(s)
      Shishido, Y., Tanaka, T., Piao, Y.S., Araki, K., Takei, N., Higashiyama, S., Nawa H.
    • Journal Title

      Biochem Biophys Res Commun. 348

      Pages: 963-970

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart valve malformation and cardiac hypertrophy.2006

    • Author(s)
      Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamutra, H., Takahashi K., Takakura, N., Mekada, E., Hashimoto, K., Higashiyama, S.
    • Journal Title

      Biochem Biophys Res Commun. 350

      Pages: 315-321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.2006

    • Author(s)
      Kikugawa, T., Kinugasa, Y., Shiraishi, K., Nanba, D., Nakashiro K., Tanji, N., Yokoyama, M., Higashiyama, S.
    • Journal Title

      The Prostate 66

      Pages: 1092-2099

    • Data Source
      KAKENHI-PROJECT-17014068
  • [Journal Article] Ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor and subcellular localization of the C-terminal fragment in a cell cycle.2005

    • Author(s)
      Toki, F., Nanba, D., Matsuura, N., Higashiyama, S.
    • Journal Title

      J. Cell. Physiol. 202

      Pages: 839-848

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Helicobacter pylori-Stimulated Interleukin-8 (IL-8) Promotes Cell Proliferation Through Transactivation of Epidermal Growth Factor Receptor (EGFR) by Disintegrin and Metalloproteinase (ADAM) Activation.2005

    • Author(s)
      Joh, T., Kataoka, H., Tanida, S., Watanabe, K., Ohshima, T., Sasaki M., Nakao, H., Ohhara, H., Higashiyama, S., Itoh, M.
    • Journal Title

      Dig Dis Sci. 50

      Pages: 2081-2089

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in Human Colon Carcinoma Cells.2005

    • Author(s)
      Itoh, Y., Joh, T., Tanida, S., Sasaki, M,.Kataoka, H., Itoh, K., Oshima, T., Ogasawara, N., Togawa, S., Wada, T., Kubota, H., Mori, Y., Ohara, H., Nomura, T., Higashiyama, S., Itoh, M.
    • Journal Title

      Cytokine 29

      Pages: 275-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in Human Colon Carcinoma Cells.2005

    • Author(s)
      Itoh, Y., Joh, T., Tanida, S., Sasaki, M., Kataoka, H., Itoh, K., Oshima, T., Ogasawara, N., Togawa, S., Wada, T., Kubota, H., Mori, Y., Ohara, H., Nomura, T., Higashiyama, S., Itoh, M.
    • Journal Title

      Cytokine 29

      Pages: 275-282

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.2005

    • Author(s)
      Mifune, M., Ohtsu, H., Suzuki, H., Nakashima, H., Brailoiu, E., Dun, N.J., Frank, G.D., Inagami, T., Higashiyama, S., Thomas, W.G., Eckhart, A.D., Dempsey, P.J., Eguchi, S.
    • Journal Title

      J. Biol Chem. 280

      Pages: 26592-26599

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37.2005

    • Author(s)
      Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., Yang, L., Higashiyama, S., Yoshimura, A, Sugai, M., Hashimoto, K.
    • Journal Title

      J.Immunol. 175

      Pages: 4662-4668

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in a cell cycle.2005

    • Author(s)
      Toki, F., Nanba, D., Matsuura, N., Higashiyama, S.
    • Journal Title

      J.Cell.Physiol. 202

      Pages: 839-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.2005

    • Author(s)
      Kozawa, J., Tokui, Y., Moriwaki, M., Li, M., Ohmoto, H., Yuan, M., Zhang, J., Iwahashi, H., Imagawa, A., Yamagata, K., Tochino, Y., Shimomura, I., Higashiyama, S., Miyagawa, J.
    • Journal Title

      Pancreas 31

      Pages: 32-42

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.2005

    • Author(s)
      Fukui, K., Yang, Q., Cao, Y., Takahashi, N., Hatakeyama, H., Wang, H., Wada, J., Zhang, Y., Marselli, L., Namno, T., Yoneda K., Onishi, M., Higashiyama S., Matsuzawa, Y., Gonzalez, F.J., Weir, G.C., Kasai, H., Shimomura, I., Miyagawa, J., Wollheim, C.B., Yamagata, K.
    • Journal Title

      Cell Metabolism 2

      Pages: 373-384

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Heparin-binding EGF-like growth factor is essential for keratinocyte migration in skin wound heaking.2005

    • Author(s)
      Shirakata, Y., Kimura, R., Nanba, D., Morimoto, C., Yokota, K., Nakamura, M., Mekada, E., Higashiyama, S., Hashimoto, K.
    • Journal Title

      J. Cell Science 118

      Pages: 2363-2370

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.2005

    • Author(s)
      Mifune, M., Ohtsu, H., Suzuki, H., Nakashima, H., Brailoiu, E., Dun, N.J., Frank, GD., Inagami, T., Higashiyama, S., Thomas, W.G, Eckhart, A.D., Dempsey, P.J., Eguchi, S.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 26592-26599

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Helicobacter pylori-Stimulated Interleukin-8 (IL-8) Promotes Cell Proliferation Through Transactivation of Epidermal Growth Factor Receptor (EGFR) by Disintegrin and Metalloproteinase (ADAM) Activation.2005

    • Author(s)
      Joh, T., Kataoka, H., Tanida, S., Watanabe, K., Ohshima, T., Sasaki, M., Nakao, H., Ohhara, H., Higashiyama, S., Itoh, M.
    • Journal Title

      Dig Dis Sci. 50

      Pages: 2081-2089

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Heparin-binding EGF-like growth factor is essential for keratinocyte migration in skin wound heaking.2005

    • Author(s)
      Shirakata, Y., Kimura, R, Nanba, D., Morimoto, C., Yokota, K., Nakamura, M, Mekada, E., Higashiyama, S., Hashimoto, K.
    • Journal Title

      J.Cell Science 118

      Pages: 2363-2370

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.2005

    • Author(s)
      Fukui, K., Yang, Q., Cao, Y., Takahashi, N., Hatakeyama, H., Wang, H., Wada, J., Zhang, Y., Marselli, L., Namno, T., Yoneda, K., Onishi, M., Higashiyama, S., Matsuzawa, Y., Gonzalez, F.J., Weir, GC., Kasai, H., Shimomura, I., Miyagawa, J., Wollheim, C.B., Yamagata, K.
    • Journal Title

      Cell Metabolism 2

      Pages: 373-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.2005

    • Author(s)
      Kozawa, J., Tokui, Y.Moriwaki, M., Li, M., Ohmoto, H., Yuan, M., Zhang, J., Iwahashi, H., Imagawa, A, Yamagata, K., Tochino, Y., Shimomura, I., Higashiyama, S., Miyagawa, J.
    • Journal Title

      Pancreas 31

      Pages: 32-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Journal Article] Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37.2005

    • Author(s)
      Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., Yang, L., Higashiyama, S., Yoshimura, A., Sugai, M., Hashimoto, K.
    • Journal Title

      J. Immunol. 175

      Pages: 4662-4668

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390081
  • [Patent] CBF1結合核酸分子およびその用途2020

    • Inventor(s)
      東山繁樹、小川敦、前川大志、八田佳子、加賀城真理
    • Industrial Property Rights Holder
      東山繁樹、小川敦、前川大志、八田佳子、加賀城真理
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-059546
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19K22564
  • [Patent] CBF1結合核酸分子およびその用途2020

    • Inventor(s)
      前川大志, 東山繁樹, 小川敦司, 八田佳子, 加賀城真理
    • Industrial Property Rights Holder
      前川大志, 東山繁樹, 小川敦司, 八田佳子, 加賀城真理
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-059546
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19K22564
  • [Patent] 細胞内輸送を介した膜蛋白質の分解又はリサイクリングの制御剤2017

    • Inventor(s)
      東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
    • Industrial Property Rights Holder
      東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-244776
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16K19038
  • [Patent] 血管新生制御剤及びその利用法2017

    • Inventor(s)
      東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
    • Industrial Property Rights Holder
      東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-193118
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16K19038
  • [Patent] 炎症性疾患治療薬のスクリーニング方法、並びに炎症性疾患の治療及び検査2012

    • Inventor(s)
      谷田諭史、城 卓志、東山繁樹、塚本宏延
    • Industrial Property Rights Holder
      谷田諭史、城 卓志、東山繁樹、塚本宏延
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-11
    • Data Source
      KAKENHI-PROJECT-24590949
  • [Patent] 新規ユビキチンリガーゼ及びその利用法2009

    • Inventor(s)
      東山繁樹、井上博文、大貫秀隆
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Filing Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Patent] 新規ユビキチンチガーゼ複合体及びその利用法2009

    • Inventor(s)
      東山繁樹、井上博文、大貫秀隆
    • Industrial Property Rights Holder
      愛媛大学
    • Industrial Property Number
      2009-277073
    • Filing Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Patent] 新規ユビキチンリガーゼ及びその利用法2009

    • Inventor(s)
      東山繁樹, 井上博文, 大貫秀隆
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Filing Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Patent] 血管新生制御剤、及びそのスクリーニンク方法、並びにスクリーニンク用キット2008

    • Inventor(s)
      東山繁樹、井上博文、大貫秀隆
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Filing Date
      2008-08-14
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Patent] 血管新生制御剤, 及びそのスクリーニング方法、並びにスクリーニング用キット2008

    • Inventor(s)
      東山繁樹、井上博文、大貫秀隆
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Filing Date
      2008-08-14
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] A novel mechanism of phosphatase activation for EGFR in HER2-positive breast cancer cells2021

    • Author(s)
      Kanako Nishiyama, Masashi Maekawa, Jun Nakayama, Akari Murakami, Yoshiaki Kamei, Yasutugu Takada, Shigeki Higashiyama
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H02763
  • [Presentation] A novel mechanism of phosphatase activation for EGFR by Cullin-3/KCTD10 ubiquitin E3 complex in HER2-positive breast cancer cells2021

    • Author(s)
      Kanako Nishiyama, Masashi Maekawa, Akari Murakami, Kaho Utsunomiya, Kana Takemoto, Erina Kusakabe, Haruna Noda, Reina Aoki, Kana Taguchi, Michiko Yamashita, Tomoya Nakagita, Jun Nakayama, Mami Chosei, Takeshi Kiyoi, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada and Shigeki Higashiyama.
    • Organizer
      2021 San Antonio Breast Cancer Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02763
  • [Presentation] A novel function of a prostate cancer-associated SPOP mutant in topoisomerase 2A-dependent DNA-protein crosslink repair2020

    • Author(s)
      Masashi Maekawaa, Ryuta Watanabeb, Miki Hieda, Tomohiko Taguchi, Noriyoshi Miura, Tadahiko Kikugawa, Takashi Saika and Shigeki Higashiyama
    • Organizer
      第79回 日本癌学会 学術総会
    • Data Source
      KAKENHI-PROJECT-18K09137
  • [Presentation] 前立腺癌細胞のtopoisomerase2A制御におけるSPOPの新規機能解明とDNA修復標的治療の治療マーカーとしての可能性2020

    • Author(s)
      渡辺隆太, 前川大志, 檜枝美紀, 田口友彦, 三浦徳宣, 菊川忠彦, 東山繁樹, 雑賀隆史
    • Organizer
      第108回日本泌尿器科学会
    • Data Source
      KAKENHI-PROJECT-18K06226
  • [Presentation] 前立腺癌細胞のtopoisomerase2A制御におけるSPOPの新規機能解明とDNA修復標的治療の治療マーカーとしての可能性2020

    • Author(s)
      渡辺隆太, 前川大志, 檜枝美紀, 田口友彦, 三浦徳宣, 菊川忠彦, 東山繁樹, 雑賀隆史
    • Organizer
      第29回泌尿器科分子・細胞研究会
    • Data Source
      KAKENHI-PROJECT-18K06226
  • [Presentation] 前立腺癌細胞株LNCaP cellsから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019

    • Author(s)
      渡辺隆太 、前川大志、三浦徳宣、菊川忠彦、 雑賀隆史、東山繁樹
    • Organizer
      第28回 泌尿器科分子・細胞研究会
    • Data Source
      KAKENHI-PROJECT-18K09137
  • [Presentation] LNCaP cellから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019

    • Author(s)
      渡辺隆太 前川大志 三浦徳宣 菊川忠彦 東山繁樹 雑賀隆史
    • Organizer
      第28回 泌尿器科分子細胞研究会
    • Data Source
      KAKENHI-PROJECT-18K09137
  • [Presentation] 前立腺癌細胞株LNCaP cellsから放出されるPSMA陽性microvesicleが及ぼす血管内皮細胞の質的変化2019

    • Author(s)
      渡辺隆太 、前川大志、三浦徳宣、菊川忠彦、 雑賀隆史、東山繁樹
    • Organizer
      第60回 日本生化学会 中国四国支部例会
    • Data Source
      KAKENHI-PROJECT-18K09137
  • [Presentation] 血管内皮細胞運動を制御する新規CUL3複合体の解析2018

    • Author(s)
      坂上倫久、藤崎亜耶子、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      第59回 日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] Regulation of the intracellular localization of Ribosomal S6 Kinase 2 (RSK2) by EGF2018

    • Author(s)
      Shinji Fukuda, Hisayo Nishida-Fukuda, Subaru Sakamoto, Deborah A. Lannigan, Shigeki Higashiyama
    • Organizer
      プロテインアイランド松山2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] CUL3複合体を標的とした新規血管新生阻害化合物の探索2018

    • Author(s)
      坂上倫久、藤崎亜耶子、竹田浩之、前川大志、高橋宏隆 、澤崎達也 、 泉谷裕則 、東山繁樹
    • Organizer
      第23回日本病態プロテアーゼ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] Cullin-3ユビキチン複合体によるshedding制御2018

    • Author(s)
      松木依理奈、近藤綾乃、楠本智章、藤原章、坂上倫久、前川大志、藤崎亜耶子、福田信治、東山繁樹、中山寛尚
    • Organizer
      第59回日本生化学会中国四国支部例会
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] 血管新生を制御するCUL3ユビキチンE3複合体依存的な細胞内膜輸送2018

    • Author(s)
      前川大志,谷川和史,坂上倫久,渡部祐司、田口友彦,東山繁樹
    • Organizer
      第59回 日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 増殖因子によるRibosomal S6 Kinase 2 (RSK2)の細胞内局在制御機構2018

    • Author(s)
      福田 信治、福田 尚代、Deborah A. Lannigan、東山 繁樹
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] Cullin-3-based E3 ubiquitin ligases as novel modulators of VEGF signal transduction2018

    • Author(s)
      Tomohisa Sakaue, Ayako Fujisaki, Masashi Maekawa, Hironori Izutani Shigeki Higashiyama
    • Organizer
      The 16th Korea-Japan Joint Symposium on Vascular Biology(K-J meeting)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3型ユビキチンリガーゼ複合体による血管新生制御機構2018

    • Author(s)
      坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、竹田浩之、中山寛尚、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3-based E3 ubiquitin ligase complex is essential for vascular endothelial cell motility2018

    • Author(s)
      14.Tomohisa Sakaue、Ayako Fujisaki、Masashi Maekawa、Hirotaka Takahashi、Tatsuya Sawasaki、Hironori Izutani、Shigeki Higashiyama
    • Organizer
      20th International Vascular Biology Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] ユビキチンリガーゼCUL3-BTB複合体解析システムの構築2017

    • Author(s)
      藤崎亜耶子、坂上倫久、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      第22回日本病態プロテアーゼ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 血管新生を制御する細胞内膜輸送関連分子の探索2017

    • Author(s)
      谷川和史、前川大志、藤崎亜耶子, 渡部祐司、東山繁樹
    • Organizer
      第58回日本生化学会中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] NEDD8化シグナル伝達経路は血管内皮細胞運動を制御する2017

    • Author(s)
      坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 新規CUL3複合体による血管新生制御機構2017

    • Author(s)
      坂上倫久、前川大志、藤崎亜耶子、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      第25回日本血管生物医学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 血管内皮細胞におけるユビキチンE3リガーゼ複合体依存的な細胞内膜輸送2017

    • Author(s)
      前川大志、谷川和史、坂上倫久、渡部祐司、田口友彦、東山繁樹
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 血管新生制御を担うCul3-based ubiquitin ligaseの機能解析2017

    • Author(s)
      坂上倫久、藤崎亜耶子、前川大志、高橋宏隆、澤崎達也、泉谷裕則、東山繁樹
    • Organizer
      第22回日本病態プロテアーゼ学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.2016

    • Author(s)
      Tomohisa Sakaue, Ayako Fujisaki, Hironori Izutani, Shigeki Higashiyama
    • Organizer
      Protein Island Matsuyama 2016 & The 14th Matsuyama International Symposium
    • Place of Presentation
      Matsuyama
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 血管内皮細胞におけるCUL3によるVEGF-A応答制御機構2016

    • Author(s)
      坂上 倫久, 藤崎 亜耶子, 泉谷 裕則, 東山 繁樹
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in endothelial cells.2016

    • Author(s)
      Sakaue Tomohisa, Fujisaki Ayako, Izutani Hironori, Higashiyama Shigeki
    • Organizer
      The 19th International Vascular Biology Meeting
    • Place of Presentation
      Boston
    • Year and Date
      2016-10-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3によるVE-cadherinモジュレーションを介した血管内皮細胞接着制御機2016

    • Author(s)
      藤崎亜耶子, 坂上倫久, 中山寛尚, 前川大志, 東山繁樹
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3-KLHL20軸による細胞内タンパク質輸送制御機構の解析2016

    • Author(s)
      宇都宮果歩, 深江舜也, 上杉恭広, 坂上倫久, 中山寛尚, 前川大志, 泉谷裕則, 東山繁樹
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] Signal strength generated by the EGF family of growth factors regulates epithelial and mesenchymal-like characteristics of immortalized mammary epithelial cell lines2016

    • Author(s)
      Shinji Fukuda, Hisayo Nishida-Fukuda, Shigeki Higashiyama
    • Organizer
      Vanderbilt Ingram Cancer Center Annual Scientific Retreat
    • Place of Presentation
      Vanderbilt Univ., Nashville, TN
    • Year and Date
      2016-05-06
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] EGFファミリー分子のshedding特性解析2016

    • Author(s)
      中山寛尚, 坂上倫久, 前川大志, 藤崎亜耶子, 東山繁樹
    • Organizer
      第57回日本生化学会中国・四国支部例会
    • Place of Presentation
      高知
    • Year and Date
      2016-05-27
    • Data Source
      KAKENHI-PROJECT-16K15221
  • [Presentation] CUL3による血管内皮細胞活性化制御機構2016

    • Author(s)
      坂上倫久, 藤崎亜耶子, 泉谷裕則, 東山繁樹
    • Organizer
      日本病態プロテアーゼ学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-08-05
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] CUL3によるVE-cadherinを介した血管内皮細胞接着制御2016

    • Author(s)
      藤崎亜耶子, 坂上倫久, 中山寛尚, 前川大志, 東山繁樹
    • Organizer
      第57回日本生化学会中国・四国支部例会
    • Place of Presentation
      高知
    • Year and Date
      2016-05-27
    • Data Source
      KAKENHI-PROJECT-16H04698
  • [Presentation] 乳がん細胞の形質転換に伴うproHB-EGFのエクトドメインシェディング活性変化2015

    • Author(s)
      河村勇志,田中涼果、難波大輔、東山繁樹
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26670143
  • [Presentation] Switching of EGFR ligands alter mammary epithelial phenotypes through the control of signal strength2015

    • Author(s)
      Shinji Fukuda, Hisayo Nishida-Fukuda, Shigeki Higashiyama
    • Organizer
      Protein Island Matsuyama International Symposium 2015
    • Place of Presentation
      愛媛大学城北キャンパス、愛媛県松山市
    • Year and Date
      2015-09-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] Reversible interconversion of mammary epithelial cell characteristics by the ligand-regulated EGFR system2015

    • Author(s)
      Hisayo Nishida-Fukuda, Shinji Fukuda, Shigeki Higashiyama
    • Organizer
      Protein Island Matsuyama International Symposium 2015
    • Place of Presentation
      愛媛大学城北キャンパス、愛媛県松山市
    • Year and Date
      2015-09-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08308
  • [Presentation] EGF受容体シグナル伝達経路の活性化強度変動による乳腺細胞間接着制御機構2014

    • Author(s)
      福田 信治,福田(西田) 尚代,東山繁樹
    • Organizer
      第55回日本生化学会中国・四国支部例会
    • Place of Presentation
      愛媛大学 南加記念ホール・校友会館
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] EGFファミリー増殖因子-EGF受容体シグナル伝達経路が制御する乳腺細胞形質の可逆的変換機構2014

    • Author(s)
      福田(西田) 尚代,福田 信治,東山繁樹
    • Organizer
      第55回日本生化学会中国・四国支部例会
    • Place of Presentation
      愛媛大学 南加記念ホール・校友会館
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] E3 ユビキチンリガーゼCUL3はVEGFR2 mRNAの安定性を制御する2013

    • Author(s)
      坂上倫久、井上博文、東山繁樹
    • Organizer
      第86回 日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] Ectodomain shedding in EGFR/ligand signaling; regulation, functional implication and imaging2013

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Matrix Metalloproteinases、Gordon Research Conferance
    • Place of Presentation
      Lucca, Italy
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Ectodomain shedding制御とEGFR/Ligandシグナリング2013

    • Author(s)
      東山繁樹、福田信二
    • Organizer
      日本病態プロテアーゼ学会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] E3 ユビキチンリガーゼCUL3は細胞骨格調節によって血管新生を制御する2013

    • Author(s)
      坂上倫久、井上博文、東山繁樹
    • Organizer
      第21回 日本血管生物医学学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] コムギ胚芽無細胞タンパク質合成系を用いた絶対定量プロテオーム解析技術の開発2013

    • Author(s)
      武森信暁、武森文子、森下了、青島理人、澤崎達也、東山繁樹
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      愛知
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Cullin3 E3 ubiquitin ligase regulates angiogenesis through the multiple protein turn-over.2013

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      The 3rd International Symposium by JSPS Core-to-Core Program “Cooperative International Framework in TGF-β Family Signaling”
    • Place of Presentation
      Matsuyama, Ehime, Japan
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] Absolute Quantitative Analysis of Urinary Proteome Alterations Using Wheat Germ Cell Free Protein Synthesis and MRM Mass Spectrometry2013

    • Author(s)
      Takemori N, Takemori A, Higashiyama S.
    • Organizer
      HUPO 11th Annual World Congress
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] G protein-coupled receptor 56 (GPR56) によるヒト培養乳腺細胞の増殖・運動能制御機構2013

    • Author(s)
      越智仁美、福田尚代、吉本彩花、福田信治、東山繁樹
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] Ectodomain shedding制御とEGFR/Ligandシグナル2013

    • Author(s)
      東山繁樹、福田信二
    • Organizer
      第18回日本病態プロテアーゼ学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] ヒト培養乳腺細胞におけるG protein-coupled receptor 56 (GPR56)の発現解析2013

    • Author(s)
      吉本彩花、福田尚代、越智仁美、福田信治、東山繁樹
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] Ectodomain shedding制御とEGFR/Ligandシグナリング2013

    • Author(s)
      東山繁樹、福田信二
    • Organizer
      日本病態プロテアーゼ学会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Ectodomain shedding in EGFR/ligand signaling; regulation, functionalimplication and imaging2013

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Matrix Metalloproteinases、Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] RNA 結合蛋白質Human antigen R による膜型増殖因子Amphiregulin のmRNA 安定化機構の解析2013

    • Author(s)
      福田信治, 中山寛尚, 松下夏樹, 福田尚代, 井上博文, 白方裕司, 橋本公二, 東山繁樹
    • Organizer
      第54回日本生化学会中国・四国支部例会
    • Place of Presentation
      徳島大学大塚講堂
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] Cullin3 E3 ubiquitin ligase-based angiogenic regulation2013

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Scientific Coordination Network (ISCN) The 3rd GDRI French Japanese Cancer Meeting
    • Place of Presentation
      Toulouse, France
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] コムギ無細胞タンパク質合成系を用いた絶対定量プロテオーム解析技術の開発2013

    • Author(s)
      武森信暁、武森文子、森下了、青島理人、澤崎達也、東山繁樹
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      愛知
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Cullin3 E3 ubiquitin ligase regulates angiogenesis through stabilizing vascular endothelial cell growth factor 2 mRNA2013

    • Author(s)
      Tomohisa Sakaue, Shigeki Higashiyama
    • Organizer
      Vascular Biology 2013
    • Place of Presentation
      Hyannis, MA, USA
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] Ectodomain shedding in EGFR/ligand signaling; regulation, functional implication and imaging. Matrix Metalloproteinases2013

    • Author(s)
      Higashiyama S.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Regulation of ectodomain shedding in EGFR/ligand signaling2012

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Scientific Coordination Network (ISCN) France-Japan
    • Place of Presentation
      Naruto, Japan
    • Year and Date
      2012-11-28
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23112513
  • [Presentation] アネキシンファミリーによるectodomain sheddingの制御機構2012

    • Author(s)
      福田信治、中山寛尚、福田尚代、井上博文、東山繁樹
    • Organizer
      第53回日本生化学会中国・四国支部例会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] Absolute Quantitative Analysis of Urinary Proteome Alteratins Using Wheat Germ Cell Free Protein Synthesis and MRM Mass Spectrometry.2012

    • Author(s)
      Takemori N, Takemori A, Higashiyama S.
    • Organizer
      HUPO 11th Annual World Congress
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-24659280
  • [Presentation] Regulation of ectodomain shedding in EGFR/ligand signaling2012

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Scientific Coordination Network(ISCN) France-Japan
    • Place of Presentation
      Naruto, Japan(招待講演)
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] BAZF mRNA-binding protein regulates stability of proangiogenic genes mRNA under a VEGF-A stimulation2012

    • Author(s)
      Hirofumi Inoue, Daisuke Miwa, Tomohisa Sakaue, Nobuaki Takemori, Katsutoshi Goishi, Shigeki Higashiyama
    • Organizer
      キーストンシンポジウム
    • Place of Presentation
      米国ユタ州Snowbird Resort
    • Data Source
      KAKENHI-PUBLICLY-23112513
  • [Presentation] Regulation of ectodomain shedding in EGFR/ligand signaling2012

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      The 2nd international Symposium by JSPS Core-to Core Program "TGF-β Family Signal Network and Tumor Microenvironment"
    • Place of Presentation
      Tokyo, Japan(招待講演)
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] RNA結合蛋白質HuRが制御する膜型増殖因子AmphiregulinのmRNA安定化機構2012

    • Author(s)
      福田信治、中山寛尚、松下夏樹、福田尚代、井上博文、白方裕司、橋本公二、東山繁樹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] モノユビキチン化による膜型増殖因子Amphiregulinの機能制御機構2012

    • Author(s)
      福田尚代、福田信治、中山寛尚、井上博文、東山繁樹
    • Organizer
      第53回日本生化学会中国・四国支部例会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] HB-EGF-CTF nuclear translocation induce gastric cancer invasion2011

    • Author(s)
      Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T.
    • Organizer
      第70会日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] TGFβによるROSおよびADAM17を介したEGF受容体transactivationのメカニズムの解析2011

    • Author(s)
      海老正秀、片岡洋望、志村貴也、溝下 勤、谷田諭史、平田慶和、神谷 武、水島隆史、東山繁樹、城 卓志
    • Organizer
      JDDW 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-22590704
  • [Presentation] ZF50 mRNA-binding protein controls vascular endotghelial growth factor-induced angiogeneic response by increasing mRNA stability of proangiogenic genes2011

    • Author(s)
      Tomohisa Sakaue, Hirofumi Inoue, Daisuke Miwa, Nobuaki Takemori, Katsutoshi Goishi, Shigeki Higashiyama
    • Organizer
      北米血管生物学会(NAVBO)
    • Place of Presentation
      米国マサチューセッツ州Cape Cod
    • Data Source
      KAKENHI-PUBLICLY-23112513
  • [Presentation] The role of monoubiqutination in the regulation of endocytosis and ectodomain shedding of a ligand of epidermal growth factor (EGF) recetor, amphiregulin2011

    • Author(s)
      Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] HB-EGF-CTFの核内移行は胃癌浸潤を促進する2011

    • Author(s)
      志村貴也,吉田道弘,福田信治,溝下 勤,片岡洋望,東山繁樹,城 卓志
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-22590704
  • [Presentation] The role of monoubiqutination in the regulation of endocytosis and ectodomain shedding of a ligand of epidermal growth factor(EGF) recetor, amphiregulin2011

    • Author(s)
      Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-15
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer2011

    • Author(s)
      Yoshida M, Shimura T, Fukuda S, Higashiyama S, Mizoshita T, Kataoka H, Joh T.
    • Organizer
      第70会日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] HB-EGF-CTFの核内移行は胃癌浸潤を促進する2011

    • Author(s)
      志村貴也, 吉田道弘, 福田信治, 溝下勤, 片岡洋望, 東山繁樹, 城卓志
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-21590790
  • [Presentation] HB-EGF-CTF nuclear translocation induce gastric cancer invasion2011

    • Author(s)
      Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] TGFβによるROSおよびADAM17を介したEGF受容体transactivationのメカニズムの解析2011

    • Author(s)
      海老正秀、片岡洋望、志村貴也、溝下勤、谷田諭史、平田慶和、神谷武、水島隆史、東山繁樹、城卓志
    • Organizer
      JDDW 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Data Source
      KAKENHI-PROJECT-21590790
  • [Presentation] TGFbeta induces shedding of proHB-EGF and EGFR transactivasion though ADAMactivation2010

    • Author(s)
      海老正秀、城卓志、神谷武、片岡洋望、久保田英嗣、溝下勤、志村貴也、村上賢治、平田慶和、東山繁樹
    • Organizer
      第69回日本癌学会総会English Workshops
    • Place of Presentation
      東京
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21590790
  • [Presentation] TGFbeta induces shedding of proHB-EGF and EGFR transactivasion though ADAM activation.2010

    • Author(s)
      海老正秀、城 卓志、神谷武、片岡洋望、久保田英嗣、溝下 勤、志村貴也、村上賢治、平田慶和、東山繁樹.
    • Organizer
      第69回 日本癌学会総会 English Workshops
    • Place of Presentation
      東京
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-22590704
  • [Presentation] Development of Ientivirus vector system for conditional gene knockdown2010

    • Author(s)
      Natsuki Mtasushita, Sachi Matsushita, Satoshi Hirakawa, Shigeki Higashiyama
    • Organizer
      第33回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] HB-EGF-C末端核移行シグナルをターゲットにした新規薬剤探索と細胞増殖抑制効果について.2010

    • Author(s)
      尾関啓司、谷田諭史、福田信治、東山繁樹、城 卓志
    • Organizer
      第47回日本消化器免疫学会総会 一般演題
    • Place of Presentation
      大津
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-22590704
  • [Presentation] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御2010

    • Author(s)
      東山繁樹
    • Organizer
      第48回日本癌治療学会 学術集会JSCO-JCA joint symposium 1「がんの微小環境(血管浸潤、がんの転移・浸潤)からのがん治療」
    • Place of Presentation
      京都
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Ectodomain shedding of LYVE-1 : VEGF-A promotes the initial step of pathological lymphoangiogenesis2010

    • Author(s)
      Satoshi Hirakawa, Shigeki Higashiyama
    • Organizer
      第18回 日本血管生物医学会学術集会 シンポジウム5 : Angiogenesis/Lymphangiogenesis
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御2010

    • Author(s)
      東山繁樹
    • Organizer
      第48回日本癌治療学会 学術集会 JSCO-JCA joint symposium 1「がんの微小環境(血管浸潤、がんの転移・浸潤)からのがん治療」
    • Place of Presentation
      京都
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death2010

    • Author(s)
      東山繁樹、井上博文
    • Organizer
      第18回日本血管生物医学会学術集会シンポジウム2 :心不全・冠動脈
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] Ectodomain shedding of LYVE-1 : VEGF-A promotes the initial step of pathological lymphoangiogenesis2010

    • Author(s)
      Satoshi Hirakawa, Shigeki Higashiyama
    • Organizer
      第18回 日本血管生物医学会学術集会 シンポジウム5:Angiogenesis/Lymphangiogenesis
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] VEGF-A induces the ectodomain shedding of LYVE-1 via MAPK path-Way in cultured lymphatic endothelial cells2010

    • Author(s)
      平川聡史, 東山繁樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場,大阪市
    • Data Source
      KAKENHI-PROJECT-20591348
  • [Presentation] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death2010

    • Author(s)
      東山繁樹、井上博文
    • Organizer
      第18回 日本血管生物医学会学術集会 シンポジウム2:心不全・冠動脈
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] C-terminal fragment signaling of proHB-EGF for protection of cardiac cell death2010

    • Author(s)
      東山繁樹、井上博文
    • Organizer
      第18回 日本血管生物医学会学術集会 シンポジウム2:心不全・冠動脈
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Identification of novel molecules that regulate ectodomain shedding of EGF ligands2010

    • Author(s)
      福田信治、中山寛尚、東山繁樹
    • Organizer
      第33回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御2010

    • Author(s)
      東山繁樹
    • Organizer
      第48回日本癌治療学会学術集会JSCO-JCA joint symposium 1「がんの微小環境(血管浸潤、がんの転移・浸潤)からのがん治療」
    • Place of Presentation
      京都
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] Identification of novel molecules that regulate ectodomain shedding of EGF ligands2010

    • Author(s)
      福田信治、中山寛尚、東山繁樹
    • Organizer
      第33回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] Identification of novel molecules that regulate ectodomain shedding of EGF ligands2010

    • Author(s)
      福田信治、中山寛尚、東山繁樹
    • Organizer
      第33回日本分子生物学会年会、第88回日本生化学会大会 合同大会3S5 : Ectodomain shedding biology-functional conversion of plasma membrane proteins-
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] HB-EGF-C末端核移行シグナルをターゲットにした新規薬剤探索と細胞増殖抑制効果について2010

    • Author(s)
      尾関啓司、谷田諭史、福田信治、東山繁樹、城卓志
    • Organizer
      第47回日本消化器免疫学会総会
    • Place of Presentation
      滋賀
    • Year and Date
      2010-07-08
    • Data Source
      KAKENHI-PROJECT-21590790
  • [Presentation] 増殖因子による増殖の正と負のシグナル制御機構と癌微小環境制御2010

    • Author(s)
      東山繁樹
    • Organizer
      第48回日本癌治療学会 学術集会JSCO-JCA joint symposium 1「がんの微小環境(血管浸潤、がんの転移・浸潤)からのがん治療」
    • Place of Presentation
      京都
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] dentification of novel molecules that regulate ectodomain shedding of EGF ligands2010

    • Author(s)
      福田信治、中山寛尚、東山繁樹
    • Organizer
      第33回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22650228
  • [Presentation] A zinc finger transcription factor regulates vascular sprouting through the downregulation of Notch signaling in vascular endothelial cells.2009

    • Author(s)
      Hidetaka Ohnuki, Hirofumi Inoue, Hironao Nakayama, Shinji Fukuda, Shigeki Higashiyama
    • Organizer
      Keystone Symposia -Angiogenesis and Lymphangiogenesis in Cancer-
    • Place of Presentation
      Big Sky Resort, Big Sky, Montana, USA (Hidetaka Ohnuki received Keystone Symposia Scholarship Award, NIH, National Cancer Institute Grant #1R13CA135834-01. )
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors2009

    • Author(s)
      東山繁樹
    • Organizer
      第61回日本細胞生物学会大会 シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors2009

    • Author(s)
      東山繁樹
    • Organizer
      第61回日本細胞生物学会大会 シンポジウム
    • Place of Presentation
      名古屋国際会議揚
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus"
    • Place of Presentation
      Ventura, California, USA
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] A zine finger transcnption factorregulates vascular sproutmg hough the down egulaion of Notch signaling in vascular endothelial cells2009

    • Author(s)
      Hidetaka Ohnuki, Shigeki Higashiyama, et.al.
    • Organizer
      Keystone Symposia-Angiiogenesis and Lymphangiogenesis in Cancer-
    • Place of Presentation
      Big Sky, MT, USA
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Nuclear signaling of membrane-anchored growth factors and cell growth regulation2009

    • Author(s)
      東山繁樹
    • Organizer
      International Symposium "New Frontiers in Cancer Research"
    • Place of Presentation
      Sapporo, Hokkaido
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] 膜型増殖因子のEctodomain Shedding-分子機構から生理機能まで2009

    • Author(s)
      東山繁樹
    • Organizer
      第73回 日本生化学会中部支部例会シンポジウム
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Nuclear signaling of membrane-anchored growth factors and cell growth regulation (Invited)2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Symposium “New Frontiers in Cancer Research"
    • Place of Presentation
      The Hokkaido University Conference Hall (北海道)
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Nuclear signaling of membrane-anchored growth factors and cell growth regulation2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Symposium "New Frontiers in Cancer Research"
    • Place of Presentation
      Sapporo, Hokkaido
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Inner nuclear membrane targetmg of membrane anchored growth factors and transcriptional regulation (Invited)2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference Signal Transduction Within The Nucleus-
    • Place of Presentation
      Ventura, CA, USA
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation (Invited)2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference-Signal Transduction Within The Nucleus-rdon Research Conference
    • Place of Presentation
      Ventura, CA, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation2009

    • Author(s)
      東山繁樹
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus" (Invited)
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2009-04-01
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] 膜型増殖因子の Ectodomain Shedding-分子機構から生理機能まで2009

    • Author(s)
      東山繁樹
    • Organizer
      第73回 日本生化学会中部支部例会 シンポジウム
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Nuclear signaling of membrane-anchored growth factors and cell growth regulation (Invited)2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Symposium "New Frontiers in Cancer Research"
    • Place of Presentation
      The Hokkaido University Conference Hall (北海道)
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] A novel amphiregulin-binding protein, ARP35, regulates the amphiregulin-ADAM17 interaction and the ectodomain shedding2009

    • Author(s)
      中山寛尚, 福田信治, 井上博文, 東山繁樹
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸(優秀プレゼンテーション賞受賞)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation (Invited).2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus"
    • Place of Presentation
      Ventura, CA, USA
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Plasma membrane-anchored growth factors HB-EGF and amphiregulin targeted to the inner nuclear membrane and regulated gene expression.2009

    • Author(s)
      Mayumi Isokane, Miki Hieda, Shigeki Higashiyama
    • Organizer
      Cold Spring Harbor Laboratory Meeting "Dynamic Organization of Nuclear Function"
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Innernuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation2009

    • Author(s)
      東山繁樹
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus"
    • Place of Presentation
      Ventura, Califomia, USA
    • Year and Date
      2009-04-01
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane translocation and nuclear signaling of membrane-anchored growth factors2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      第61回日本細胞生物学会大会シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Inner nuclear membrane targeting of membrane-anchored growth factors and transcriptional regulation2009

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      Gordon Research Conference "Signal Transduction within the Nucleus"
    • Place of Presentation
      Ventura, California, USA
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] A zinc finger transcription factor regulates vascular sprouting through the downregulation of Notch signaling in vascular endothelial cells.2009

    • Author(s)
      Hidetaka Ohnuki, Shigeki Higashiyama, et al.
    • Organizer
      Keystcne Symposia-Angiogenesis and Lymphangiogenesis in Cancer-
    • Place of Presentation
      Big Sky, MT, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Plasma membrane anchored growth factors HB-EGF and amphiregulin targeted to the inner nuclear membrane and regulate gene expressioa.2008

    • Author(s)
      Mayumi Isokane, Shigeki Higashiyama, et al.
    • Organizer
      Cold Spring Harbor Laboratory Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, U.S.A.
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Plasma membrane anchored growth factors HB EGF and amphmegulm targeted to the inner nuclear membrane and regulate gene expression2008

    • Author(s)
      Maynmi Isokane, Shigeki Higashiyama, et.al.
    • Organizer
      Cold Spring Harbor Laboratory Meeting
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] 膜型増殖因子amphiregulinの細胞内輸送経路およびその解析2008

    • Author(s)
      礒兼真由美, 東山繁樹, (他2名)
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフイコ横浜 (横浜)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, Satoshi Hirakawa, Koichi Nakashiro, Koji Hashimoto, Hiroyuki Hamakawa and Shigeki Higashiyama
    • Organizer
      12th International Congress on Oral Cancer conjunction with 24th Congress of ICMFS (former IAMFS)
    • Place of Presentation
      Shanghai, China
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Inner nuclear membrane targeting of pro-amphiregulin regulates Oral Squamous Cell Carcinoma cell viability2008

    • Author(s)
      Mayumi Isokane, Shigeki Higashiyama, et al.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際議場 (名古屋)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Plaama membrane anchored growth factors proHB-EGF and proamphiregulin targeted to the nuclear inner membrane and regulate gene expression (Symposium)2008

    • Author(s)
      Shigeki Higashiyama, et al.
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Intracellular transport of membrane-anchored EGF family growth factor from the plasma membrane to the inner nuclear membrane 「膜型増殖因子EGF ファミリー分子は細胞膜から核膜へ局在変化する」2008

    • Author(s)
      檜枝美紀、礒兼真由美、東山繁樹
    • Organizer
      第60回日本細胞生物学会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] 膜型填殖因子amphiregulinの細胞内輪送経路およびその解析2008

    • Author(s)
      礒兼真由美、東山繁樹 (他2名)
    • Organizer
      第60回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] The ectodomian shedding of amphiregulin (AREG) is regulated by a 35kDa protein, a novel proAREG associated protein2008

    • Author(s)
      Hironao Nakayama, Shigeki Higashiyama, et al.
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Inner nuclear membrane targeting of pro-amphiregulin regulates oral squamous cell carcinoma cell viability2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, Eriko Koya, Koichi Nakashiro, Hiroyuki Hamakawa and Shigeki Higashiyama
    • Organizer
      第67回日本癌学会学術総会 (ミニシンポジウム・口頭発表)
    • Place of Presentation
      愛知県・名古屋市
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Plasma membrane anchored growth factors HB-EGF and mamphiregulin targeted to the inner nuclear membrane and regulate gene expression2008

    • Author(s)
      Mayumi Isokane, Miki Hieda, and Shigeki Higashiyama
    • Organizer
      Cold Spring Harbar meeting, Nuclear structure and function Dynamic Organization of Nuclear Function (ポスタ ー発表)
    • Place of Presentation
      Cold Spring Harbar, NY, U.S.A.
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] The plasma membrane-anchored growth factor, amphiregulin, binds A-type lamin and regulates global transcription 「膜型増 殖因子amphiregulin の細胞内輸送経路およびその機能解析」2008

    • Author(s)
      礒兼真由美、檜枝美紀、東山繁樹
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Inner nuclear membrane translocation and transcriptional regulation of proHB-EGF and pro-amphiregulin (International Session)2008

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際議場(名古屋)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] 膜型増殖因子EGFファミリー分子は細胞膜から核膜へ局在変化する2008

    • Author(s)
      檜枝美紀、東山繁樹(他1名)
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] 膜型増殖因子の核膜内膜移行とがん細胞特性の変化2008

    • Author(s)
      東山繁樹
    • Organizer
      文部科学省, 厚生労働省がん研究合同シンポジウム
    • Place of Presentation
      学術総合センター一橋記念講堂(東京)、招待講演
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Ectodomian shedding of EGF family members -the molecular mechanism and the physiological roles- (Symposium)2008

    • Author(s)
      Hirofumi Inoue, Shigeki Higashiyama, et al.
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド (神戸)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] 膜型増殖因子の核膜内膜移行による転写調節2008

    • Author(s)
      東山繁樹
    • Organizer
      特定領域研究「核ダイナミクス」「遺伝情報デコード」合同シンポジウム「クロマチンシグナリングの分子機構」
    • Place of Presentation
      東京ステーションカンファレンス
    • Year and Date
      2008-01-08
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] 膜型増殖因子EGFファミリー分子は細胞膜から核膜へ局在変化する2008

    • Author(s)
      檜枝美紀, 東山繁樹, (他1名)
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフイコ横浜 (横浜)
    • Data Source
      KAKENHI-PROJECT-20390082
  • [Presentation] Amphiregulin overexpressed in Oral Squamous Cell Carcinoma cell lines accumulates at the inner nuclear membrane.2007

    • Author(s)
      Mayumi Isokane, Shigeki Higashiyama, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Molecular target therapy for gastric cancer. suppression of proHb-EGF carboxy-terminal fragment nuclear translocation,2007

    • Author(s)
      Takaya Shimura, Shigeki Higashiyama, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] The carboxy-terminal fragment of proHB-EGF reverses Bc16-mediated gene expression.2007

    • Author(s)
      Yumi Kinugasa, Shigeki Higashiyama, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Membrane-anchored growth factor, HB-EGF targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda, Shigeki Higashiyama, etc.
    • Organizer
      第40回発生生物学会第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007

    • Author(s)
      上谷 晃由、井上 博文、東山 繁樹
    • Organizer
      30回日本分子生物学学会年会・第80回日本生化学学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Data Source
      KAKENHI-PROJECT-18590298
  • [Presentation] 膜型増殖因子による遺伝子転写制御機構(招待講演)2007

    • Author(s)
      東山繁樹
    • Organizer
      第44回日本口腔組織培養学会
    • Place of Presentation
      松山
    • Year and Date
      2007-12-01
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrance-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Hieda M, and Higashiyama S.
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      兵庫県洲本町
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] 「膜型増殖因子HB-EGFは核膜内膜に移行し転写を調節する2007

    • Author(s)
      檜枝美紀、衣笠由美、東山繁樹
    • Organizer
      核ダイナミクス研究会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      淡路島
    • Year and Date
      2007-11-27
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      EMBO Conference Series on Nuclear Structure and Dynamics Montpellier
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      国際シンポジウム「メンブレントラフィック」
    • Place of Presentation
      淡路島
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007

    • Author(s)
      上谷 晃由、井上 博文、東山 繁樹
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590298
  • [Presentation] Molecular Mechanism of cardiac cell death regulated by ectodomain Shedding of growth factor2007

    • Author(s)
      Teruyoshi, Uetani, Hirofumi, Inoue, Shigeki, Higashiyama
    • Organizer
      Biochemistry and Molecular Biology 2007
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-12-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590298
  • [Presentation] Sheddingフィールド形成因子同定と増殖因子シグナル制御機構2007

    • Author(s)
      中山寛尚、井上博文、東山繁樹
    • Organizer
      第30回日本分子生物学会 第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007

    • Author(s)
      上谷晃由、井上博文、大蔵隆文、檜垣實夫、東山繁樹
    • Organizer
      第30回日本分子生物学会 第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] 癌微小環境における細胞特性の変化-膜型増殖因子の役割(招待講演)2007

    • Author(s)
      東山繁樹
    • Organizer
      第59回日本泌尿器科学会西日本総会
    • Place of Presentation
      松山
    • Year and Date
      2007-11-10
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrane-anchored growth factor, HB-EGF targets tothe nuclear membrane and regulates gene expression2007

    • Author(s)
      Hieda M, Kinugasa Y, Higashi C., Tachibana T, Taguchi T., and Higashiyama S.
    • Organizer
      第40回発生生物学会第49回日本細胞生物学会合同大会
    • Place of Presentation
      福岡県福岡市
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrane-anchored growth factor, HB-EGF targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda, Yumi Kinugasa, Chizuru Higashi, Taro Tachibana, Tomohiko Taguchi, and Shigeki Higashiyama
    • Organizer
      第40回発生生物学会第49回日本細胞生物学会合同大会
    • Place of Presentation
      福岡県福岡市国際会議場
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] Membrane-anchored growth factor amphiregulin translocates to the inner nuclear memberane via retrograde membrane trafficking.2007

    • Author(s)
      Mayumi Isokane, Shigeki Higashiyama, etc.
    • Organizer
      第40回発生生物学会第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-06-01
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membrane and regulates gene expression2007

    • Author(s)
      Miki Hieda and Shigeki Higashiyama
    • Organizer
      EMBO Conference Series on Nuclear structure and Dynamics
    • Place of Presentation
      Montpellier、France
    • Year and Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Membrane-anchored growth factor amphiregulin translocates to the inner nuclear membrane via retrograde membrane trafficking.2007

    • Author(s)
      Mayumi Isokane, Shigeki Higashiyama, et. al.
    • Organizer
      EMBO Conference Series on Nuclear structure and Dynamics
    • Place of Presentation
      Montpellier、France
    • Year and Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-17014068
  • [Presentation] Membrane-anchored growth factor HB-EGF on cell surface targets to the nuclear membra ne and regulates gene expression2007

    • Author(s)
      Hieda M, and Higashiyama S.
    • Organizer
      EMBO Conference Series on Nuclear Structure and Dynamics
    • Place of Presentation
      フランス モンペリエ
    • Data Source
      KAKENHI-PROJECT-19570182
  • [Presentation] EGFファミリーの増殖因子による乳腺細胞の細胞間接着制御機構

    • Author(s)
      福田 信治,福田(西田)尚代,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] EGF受容体シグナルによる乳腺細胞の可逆的な表現型変換の制御機構解析

    • Author(s)
      福田(西田) 尚代,福田 信治,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26670143
  • [Presentation] Angiogenic regulation by CUL3

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      第73回日本癌学会学術総会 シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] 乳がん細胞における形質転換とproHB-EGFのエクトドメインシェディングの相関性

    • Author(s)
      河村勇志,田中涼果、難波大輔、東山繁樹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26670143
  • [Presentation] The EGF family growth factors generate distinct mammary cell types through the regulation of EGFR signaling pathway

    • Author(s)
      Shinji Fukuda, Nishida-Fukuda Hisayo, Shigeki Higashiyama
    • Organizer
      プロテイン・アイランド・松山 国際シンポジウム2014
    • Place of Presentation
      愛媛大学 南加記念ホール
    • Year and Date
      2014-09-16 – 2014-09-17
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] Cullin3 E3 ubiquitin ligase-based angiogenic regulation

    • Author(s)
      Shigeki Higashiyama
    • Organizer
      International Scientific Coordination Network (ISCN) The 4th GDRI French Japanese Cancer Meeting
    • Place of Presentation
      京都 関西セミナーハウス
    • Year and Date
      2014-11-20 – 2014-11-23
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] EGF受容体シグナルによる乳腺細胞の可逆的な表現型変換の制御機構解析

    • Author(s)
      福田(西田) 尚代,福田 信治,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] EGF受容体シグナル伝達経路の活性化強度変動による乳腺細胞間接着制御機構

    • Author(s)
      福田 信治,福田(西田) 尚代,東山繁樹
    • Organizer
      第55回日本生化学会中国・四国支部例会
    • Place of Presentation
      愛媛大学 南加記念ホール
    • Year and Date
      2014-06-06 – 2014-06-07
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] 乳がん細胞における形質転換とproHB-EGFのエクトドメインシェディングの相関性

    • Author(s)
      河村勇志,田中涼果、難波大輔、東山繁樹
    • Organizer
      第73回日本癌学会学術総会 シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24390074
  • [Presentation] EGFファミリーの増殖因子による乳腺細胞の細胞間接着制御機構

    • Author(s)
      福田 信治,福田(西田)尚代,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26670143
  • [Presentation] EGFファミリーの増殖因子による乳腺細胞の細胞間接着制御機構

    • Author(s)
      福田 信治,福田(西田)尚代,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24590382
  • [Presentation] CUL3はRhoタンパク質の発現および活性制御を介して血管新生を調節する

    • Author(s)
      坂上倫久、東山繁樹
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都 国際会議場
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PUBLICLY-25112712
  • [Presentation] EGF受容体シグナルによる乳腺細胞の可逆的な表現型変換の制御機構解析

    • Author(s)
      福田(西田) 尚代,福田 信治,東山繁樹
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24590382
  • 1.  JOH Takashi (30231369)
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  • 2.  MATSUURA Nariaki (70190402)
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  • 3.  FUKUDA SHINJI (70398238)
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  • 6.  雑賀 隆史 (10314676)
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  • 81.  永渕 昭良 (80218023)
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  • 88.  武田 憲昭 (30206982)
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  • 116.  武田 力
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  • 117.  RUDA Maryan
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  • 118.  KOLODOKIN Al
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  • 119.  ALLEN Nick
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  • 120.  UHL George R
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  • 121.  OTA Ichiro
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  • 122.  IMAI Yuuki
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  • 123.  KAWAI Katsuhisa
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  • 124.  徳久 剛史
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  • 125.  桝 和子
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  • 126.  桝 正幸
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  • 127.  渡利 彰浩
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  • 128.  泉谷 裕則
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  • 129.  中城 公一
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  • 130.  榊原 伊織
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  • 131.  小澤 岳昌
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  • 132.  荒木 伸一
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  • 133.  武井 延之
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  • 134.  吉田 清嗣
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  • 135.  村上 朱里
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