• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

NAGAYA Hisao  長屋 寿雄

ORCIDConnect your ORCID iD *help
Researcher Number 60464343
Other IDs
Affiliation (based on the past Project Information) *help 2015 – 2022: 兵庫医科大学, 医学部, 助教
2011 – 2013: 兵庫医科大学, 医学部, 助教
2009 – 2010: The University of Tokushima, 疾患酵素学研究センター, 助教
2007: The University of Tokushima, Institute for Enzyme Research, Assistant Professor
Review Section/Research Field
Principal Investigator
General medical chemistry
Except Principal Investigator
Urology / Pathological medical chemistry / Tumor therapeutics
Keywords
Principal Investigator
MMP / ELISA / インスリン受容体 / インスリンシグナル伝達 / 生体分子医学
Except Principal Investigator
膀胱癌 / ナフトピジル / AS160 / GLUT4トランスロケーション / シグナル伝達 … More / ターゲット探索 / 抗がん活性 / 光学分割 / ドラッグリポジショニング / アフィニティ樹脂 / 塩酸塩 / 溶解性 / 悪性中皮腫 / in vio評価 / 薬物動態 / 膀胱がん / 代謝物 / 探索合成 / 中皮腫 / QOL / ドラッグ・リポジショニング / Gq coupled receptor / GLUT4 translocation / signal transduction / diabetes / soluble ectodomain / insulin receptor / インスリン / Gq共役受容体 / 糖尿病 / 可溶性細胞外ドメイン / インスリン受容体 / 抗腫瘍効果 / CD46蛋白質 / アデノウイルス / 腎臓癌 / CAR / CD46 / 遺伝子治療 / アデノウイルスベクター / BIG2 / ARF / BFA / 超高感度sIR測定法 / 高血糖 / sIR / TUG / GLUT4 / インスリン作用 / インスリンシグナル伝達 / 分子病態学 Less
  • Research Projects

    (6 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (10 People)
  •  Discovery of a novel naftopidil-based therapeutic agent for malignant mesothelioma and mechanism of action

    • Principal Investigator
      Tadashi Shimizu
    • Project Period (FY)
      2016 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Hyogo Medical University
      Hyogo University of Health Sciences
  •  Development of novel therapeutic methods for innovative bladder cancer by drug repositioning

    • Principal Investigator
      GOTOH AKINOBU
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Hyogo Medical University
  •  Development of new therapy using novel chimeric oncolytic adenoviruse vector for intractable bladder cancer.

    • Principal Investigator
      GOTOH Akinobu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Hyogo Medical University
  •  Mechanism of secreting soluble insulin receptor in diabetesPrincipal Investigator

    • Principal Investigator
      NAGAYA Hisao
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of Insulin signal transduction and diabetes mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of insulin signal transduction and diabetes mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima

All 2016 2015 2014 2013 2012 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] Piperazine-based alpha-1 AR blocker, naftopidil, selectively suppresses malignant human bladder cells via induction of apoptosis.2016

    • Author(s)
      Nakagawa Yusuke U, Nagaya Hisao, Miyata Takeaki, Wada Yoshitaka, Oyama Tsunehiro, Gotoh Akinobu.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 1563-1570

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Journal Article] Repositioned alpha-1 adrenoceptor blockers as anti-tumor drugs.2015

    • Author(s)
      Nagaya Hisao, Nakagawa Yusuke U, Gotoh Akinobu.
    • Journal Title

      Personalized Medicine Universe

      Volume: 4 Pages: 23-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Journal Article] Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor2013

    • Author(s)
      Niba ET, Nagaya H, Kanno T, Tsuchiya A, Gotoh A, Tabata C, Kuribayashi K, Nakano T, Nishizaki T
    • Journal Title

      Cell Physiol Biochem

      Volume: 31 Pages: 905-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] A3 Adenosine receptor mediates apoptosis in in vitro RCC4-VHL human renal cancer cells by up-regulating AMID expression.2013

    • Author(s)
      Nagaya H, Gotoh A, Kanno T, Nishizaki T
    • Journal Title

      J Urol

      Volume: 189 Issue: 1 Pages: 321-328

    • DOI

      10.1016/j.juro.2012.08.193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor.2013

    • Author(s)
      Niba ET, Nagaya H, Kanno T, Tsuchiya A, Gotoh A, Tabata C, Kuribayashi K, Nakano T, Nishizaki T
    • Journal Title

      Cell Physiol Biochem

      Volume: 31 Issue: 6 Pages: 905-913

    • DOI

      10.1159/000350108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] A_3 Adenosine receptor mediates apoptosis in in vitro RCC4-VHL human renal cancer cells by up-regulating AMID expression2013

    • Author(s)
      Nagaya H, Gotoh A, Kanno T, Nishizaki T
    • Journal Title

      J Urol

      Volume: 189 Pages: 321-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] Fiber-substituted conditionally replicating adenovirus Ad5F35 induces oncolysis of human bladder cancer cells in in vitro analysis2013

    • Author(s)
      Gotoh A, Nagaya H, Kanno T, Tagawa M, Nishizaki T
    • Journal Title

      Urology

      Volume: 81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] Fiber-substituted conditionally replicating adenovirus Ad5F35 induces oncolysis of human bladder cancer cells in in vitro analysis.2013

    • Author(s)
      Gotoh A, Nagaya H, Kanno T, Tagawa M, Nishizaki T.
    • Journal Title

      Urology.

      Volume: 81 Issue: 4 Pages: 920.e7-920.e11

    • DOI

      10.1016/j.urology.2012.12.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591951, KAKENHI-PROJECT-23592354
  • [Journal Article] Fiber-substituted conditionally replicating adenovirus for oncolysis of human renal carcinoma cells.2012

    • Author(s)
      Nagaya H, Tagawa M, Hiwasa K, Terao S, Kanno T, Nishizaki T Gotoh A.
    • Journal Title

      Anticancer Res

      Volume: 32 Pages: 2985-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Journal Article] Regulated motion of proteins in the endoplasmic reticulum2009

    • Author(s)
      Nagaya H., Tamura T.
    • Journal Title

      Seikagaku 81(7)

      Pages: 605-609

    • NAID

      10025188391

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Journal Article] 小胞体内分泌タンパク質のダイナミクスの制御機構2009

    • Author(s)
      長屋寿雄, 田村拓
    • Journal Title

      生化学(日本生化学会) Vol.81, Issue 7

      Pages: 605-609

    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] 未分化胃がん細胞に対するナフトピジルの抗腫瘍効果(Antitumor effect of naftopidil against undifferentiated gastric cancer cells.)2016

    • Author(s)
      中村安澄, 長屋寿雄, 宮田剛彰, 小山倫浩, 松本浩彦, 後藤章暢.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Presentation] 排尿障害治療薬による抗腫瘍メカニズムの解明2016

    • Author(s)
      中村安澄, 長屋寿雄, 和田義孝, 小野義春, 後藤章暢.
    • Organizer
      第22回国際個別化医療学会学術集会
    • Place of Presentation
      大崎ブライトコアホール(東京都品川区)
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Presentation] ドラッグリポジショニング法を用いた新規抗がん剤の開発(Development of the new anti-cancer drug using drug repositioning methods.)2015

    • Author(s)
      長屋寿雄, 中川佑介, 馬渕美雪, 宮田剛彰, 小山倫浩, 松本浩彦, 後藤章暢
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Presentation] 革新的膀胱癌新規治療法の開発2015

    • Author(s)
      中川佑介, 長屋寿雄, He, Yun-Chi, 清水 忠, 馬渕美雪, 田中明人, 後藤章暢
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、金沢市アートホール他(石川県、金沢市)
    • Year and Date
      2015-04-19
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Presentation] ナフトピジルの新規抗がん剤としての適応拡大に関する研究2015

    • Author(s)
      中村安澄, 長屋寿雄, 中川佑介, 宮田剛彰, 小山倫浩, 松本浩彦, 後藤章暢
    • Organizer
      第21回国際個別化医療学会学術集会
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター(大阪府、大阪市)
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-15K10613
  • [Presentation] 生薬成分と分子標的薬を用いた併用療法によるがん治療のための基礎研究2014

    • Author(s)
      長屋寿雄,中川佑介,宮田剛彰,下村欣也,小山倫浩,後藤章暢
    • Organizer
      第23回泌尿器科分子・細胞研究会
    • Place of Presentation
      山形
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Antitumor Effect of Alpha1-Adrenoceptor Blockers on Human Urological Cancer Cells(泌尿器系癌に対するα1ブロッカーの抗腫瘍効果の検討)2013

    • Author(s)
      中川佑介,長屋寿雄,宮田剛彰,下村欣也,日和佐一弘,西崎知之,後藤章暢
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Antitumor Effect of Alpha1-Adrenoceptor Blockers on Human Urological Cancer Cells(泌尿器系癌に対するα1ブロッカーの抗腫瘍効果の検討).2013

    • Author(s)
      中川佑介, 長屋寿雄, 宮田剛彰, 下村欣也, 日和佐一弘, 西崎知之, 後藤章暢
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Oncolytic effects of a fiber knob substituted adenovirus vector to human lung cancer cells.2013

    • Author(s)
      Nagaya H, Kanno T, Hiwasa K, Nakagawa Y, Shimomura K, Nakano T, Nishizaki T, Tagawa M, Gotoh A
    • Organizer
      第19回日本遺伝子治療学会年次学術集会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Crosstalk between ERK and Akt pathways in malignant mesothelioma cells(中皮腫細胞株におけるERKシグナルとAktシグナルのクロストークの検討).2013

    • Author(s)
      長屋寿雄, 中川佑介, 宮田剛彰, 下村欣也, 日和佐一弘, 中野孝司, 西崎知之, 後藤章暢
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Oncolytic effects of a fiber knob substituted adenovirus vector to human lung cancer cells2013

    • Author(s)
      Nagaya H, Kanno T, Hiwasa K, Nakagawa Y, Shimomura K, Nakano T, Nishizaki T, Tagawa M, Gotoh A
    • Organizer
      第19回日本遺伝子治療学会年次学術集会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Crosstalk between ERK and Akt pathways in malignant mesothelioma cells(中皮腫細胞株におけるERKシグナルとAktシグナルのクロストークの検討)2013

    • Author(s)
      長屋寿雄,中川佑介,宮田剛彰,下村欣也,日和佐一弘,中野孝司,西崎知之,後藤章暢
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] 腎癌細胞株に対するファイバー改変アデノウイルスベクターによるin vitroでの抗腫瘍効果の検討2012

    • Author(s)
      長屋寿雄、寺尾秀治、日和佐一弘、田川雅敏、後藤章暢
    • Organizer
      第21回 泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Oncolytic effects of a fiber knob substituted adenovirus vector to human bladder carcinoma cells.2012

    • Author(s)
      Nagaya H, Terao S, Hiwasa K, Tagawa M, Gotoh A.
    • Organizer
      第18回日本遺伝子治療学会年次学術集会
    • Place of Presentation
      ホテル熊本テルサ(熊本)
    • Data Source
      KAKENHI-PROJECT-23592354
  • [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2010

    • Author(s)
      Yuasa Tomoyuki, Nagaya Hisao, Hashida Seiichi, Asako Umehara, Yokota Ichiro, Obata Toshiyuki, Ebina Yousuke
    • Organizer
      XI INTERNATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION
    • Place of Presentation
      Naples
    • Data Source
      KAKENHI-PROJECT-20390095
  • [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2010

    • Author(s)
      Yuasa Tomoyuki, Nagaya Hisao, Hashida Seiichi, Asako Umehara, Yokota Ichiro, Obata Toshiyuki, Ebina Yousuke
    • Organizer
      XI INTERNATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION
    • Place of Presentation
      Naplaes
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる2009

    • Author(s)
      湯浅智之, 小畑利之, 横田一郎, 岡本英治, 長屋寿雄, 橋田誠一, 前川聡, 柏木厚典, 松本満, 松本俊夫, 岸和弘, 蛯名洋介
    • Organizer
      1型糖尿病研究会, 第7回1型糖尿病研究会
    • Place of Presentation
      日光
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker2009

    • Author(s)
      湯浅智之, 矢野聖二, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
    • Organizer
      第68回 日本癌学会学術総会記事,pp.450-450
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-20390095
  • [Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker, The Japanese Cancer Association2009

    • Author(s)
      Yuasa Tomoyuki, Yano Seiji, Nishioka Yasuhiko, Kubo Yoshiaki, Takahashi Masayuki, Nakatsuji Hiroyoshi, Nagaya Hisao, Kanayama Hiro-omi, Arase Seiji, Sone Saburo, Ebina Yousuke
    • Organizer
      第68回日本癌学会学術総会記事, pp.450-450
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2009

    • Author(s)
      Yuasa Tomoyuki, Obata Toshiyuki, Yokota Ichiro, Okamoto Eiji, Kanezaki Yoshiko, Maegawa Hiroshi, Hirota Fumiko, Kishi Kazuhiro, Hashida Seiichi, Nagaya Hisao, Yuko Ogura, Kazuhiko Masuda, Matsumoto Mitsuru, Matsumoto Toshio, Kashiwagi Atsunori, Ebina Yousuke
    • Organizer
      International Symposium on Diabetes -Kickoff of Hannover-Tokushima Research Communiation
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] 可溶化インスリン受容体細胞外ドメイン(sIR)は癌患者血清中で増加している2009

    • Author(s)
      湯浅智之, 小畑利之, 矢野聖二, 岡本英治, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
    • Organizer
      第29回日本分子腫瘍マーカー研究会事務局, 第29 回日本分子腫瘍マーカー研究会プログラム, pp.70-71
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790279
  • [Presentation] 可溶化インスリン受容体細胞外ドメイン(sIR)は癌患者血清中で増加している2009

    • Author(s)
      湯浅智之, 小畑利之, 矢野聖二, 岡本英治, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
    • Organizer
      第29回日本分子腫瘍マーカー研究会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-30
    • Data Source
      KAKENHI-PROJECT-20390095
  • [Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる2009

    • Author(s)
      湯浅智之, 小畑利之, 横田一郎, 岡本英治, 長屋寿雄, 橋田誠一, 前川聡, 柏木厚典, 松本満, 松本俊夫, 岸和弘, 蛯名洋介
    • Organizer
      第7回1型糖尿病研究会
    • Place of Presentation
      日光
    • Year and Date
      2009-11-07
    • Data Source
      KAKENHI-PROJECT-20390095
  • [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2008

    • Author(s)
      Yuasa Tomoyuki, Obata Toshiyuki, Yokota Ichiro, Okamoto Eiji, Kanezaki Yoshiko, Maegawa Hiroshi, Hirota Fumiko, Kishi Kazuhiro, Hashida Seiichi, Nagaya Hisao, Yuko Ogura, Kazuhiko Masuda, Matsumoto Mitsuru, Matsumoto Toshio, Kashiwagi Atsunori, Ebina Yousuke
    • Organizer
      The 1st Insulin Resistance in Metabolic Disease Forum
    • Place of Presentation
      Osaka
    • Year and Date
      2008-08-20
    • Data Source
      KAKENHI-PROJECT-20390095
  • 1.  EBINA Yousuke (00112227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  UCHIYAMA Keiji (60294039)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  YUASA Tomoyuki (50304556)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  OGURA Yuko (90464354)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  GOTOH Akinobu (70283885)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 22 results
  • 6.  TAGAWA Masatoshi (20171572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 7.  Tadashi Shimizu (40509022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  小畑 利之 (40325296)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  勅使河原 匡 (40403737)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  大野 喜也 (40509155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi