Miyoshi Kei 三好圭

… Alternative Names

MIYOSHI Kei 三好圭

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Researcher Number	70755272
Affiliation (Current)	2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 九州大学, 医学研究院, 共同研究員 2016 – 2022: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55040:Respiratory surgery-related / Digestive surgery / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Respiratory surgery
Keywords	Principal Investigator 膵癌 / 癌微小環境 / オルガノイド / 膵星細胞 / ゲノムワイドスクリーニング / 樹状細胞 / 免疫微小環境 / 免疫療法 / Genom wide screening / CRISPR-Cas9 … More / 樹状細胞(DC) / 膵癌subtype分類 / 膵癌オルガノイド / シングルセル発現解析 / 膵癌subtype / シングルセル解析 / 膵癌Subtype / 微小環境因子 / 癌関連線維芽細胞 / PSC / 癌間質相互作用 / 微小環境 / 肝転移 / エクソソーム … More Except Principal Investigator 膵癌 / 新規治療法開発 / 浸潤能 / 増殖能 / 浸潤 / 増殖 / 癌微小環境 / 抗腫瘍効果 / Hedgehogシグナル / PTPN3 / 予後予測因子 / 腫瘍形成能 / 悪性形質誘導 / 肺NET / 膵星細胞 / 腫瘍微小環境 / 遊走能 / 癌悪性形質 / 癌組織浸潤リンパ球 / チロシンキナーゼ / 免疫チェックポイント / 活性化リンパ球 / 癌間質相互作用 / 樹状細胞 / 浸潤抑制 / 増殖抑制 / 癌免疫治療 / 遊走 / 癌治療法開発 / 癌悪性形質誘導 / 新規治療標的 / 診断補助因子 / 腫瘍形成 / 治療標的因子 / 免疫チェックポイント分子 / 腫瘍免疫 / CD8T細胞 / MAML3 / Notchシグナル / リンパ球 / 免疫監視機構構築 / 癌浸潤リンパ球 / 細胞傷害性リンパ球 / 癌線維化 / 免疫治療 / 抗癌剤感受性 / 胆嚢癌 / Hedgehog signal / 小細胞肺癌 / オルガノイド / CAF / 腹膜播種 / 腹膜中皮細胞 / single cell RNA sequence / 空間情報 / 化学療法 / 胃癌 / TLS / scRNA-seq / 食道癌 / B細胞 / 抗原提示細胞 / 消化器癌 / 予後因子 / FAM115c / バイオマーカー / 遊走抑制 / 肺神経内分泌腫瘍 / FAM115C / 空間的トランスクリプトーム解析 / 癌関連線維芽細胞 (CAF) / 腫瘍微小環境 (TME) / heterogeneity / 大腸癌 / 胆のうがん / 形態形成シグナル / NOTCHシグナル / 捕捉能 / グランザイムB / IFN-gamma / CD86 / CD80 / 細胞傷害性Tリンパ球 / CD4T細胞 / チロシンキナーゼ脱リン酸化酵素 / 新規がん免疫治療開発 / 抗原提示能 / リンパ球活性化 / 抗体医薬 / オートファジー / 癌関連線維芽細胞 / 腫瘍促進性好中球 / 腫瘍免疫微小環境 / CCL5 / TAN / 好中球 / 癌遊走 / 癌浸潤 / 癌増殖 / PTPH1 / 新規シグナル経路 / 微小環境 / クラスター浸潤 / 上皮間葉転換 / エピジェネティック / collective invasion / partial EMT / 癌抗原認識他家細胞傷害性Tリンパ球 / 癌再発制御 / 癌抗原 / cell cycle再進入 / cell cycle離脱 / 癌再発 / 免疫監視構築 / 細胞周期再進入 / 細胞周期離脱 / 細胞周期 / 新規癌治療法開発 / 低酸素環境 / C4orf47 / 癌休眠 / G0/G1アレスト / 細胞周期再進入癌 / 細胞周期離脱癌 / 膵癌治療 / MAPK経路 / 免疫治療効果増強 / 新規免疫治療 / 免疫治療j効果増強 / 新規癌免疫治療 / 固形癌 / 癌免疫治療開発 / 免疫寛容 / 癌組織線維化 / 細胞性免疫能亢進 / 制御性T細胞 / SCLC / RBPJ / 免疫チェックポイント阻害剤 / リンパ球浸潤 / 免疫監視機構 / hedgehog阻害剤 / 線維化 / リンパ球組織浸潤 / ヘッジホッグ阻害剤 / 抗PD-1抗体 / スキルス胃癌 / Gli1 / 転写因子 / Gli2 / GLI2 / クロストーク経路 / シグナルクロストーク / TrkB / 治療薬創生 / BDNF / TRKB / hedgehog signal / PSC / clearance / organoid / 脂肪由来間質細胞 / spheroid / leading cell / 播種 / 免疫細胞 / 膵微小環境 / リモデリング / 中皮細胞 / 間質リモデリング / リーディングセル Less

網羅的解析による膵癌免疫抑制環境メカニズムの解明Principal Investigator
- Principal Investigator
  
  三好圭
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Elucidation of the tumor-associated neutrophil creating the immunosuppressive microenvironment in pancreatic cancer
- Principal Investigator
  
  HORIOKA Kohei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Analysis of a biological significance of PTPN3 expressed on dendritic cells for development of a new cancer immunotherapy
- Principal Investigator
  
  MORISAKI Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University
Development of a new therapeutic strategy for gallbladder cancer targeting MAML3 by the inhibition of both Hh and Notch signaling
- Principal Investigator
  
  山崎章生
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Spatial transcriptome analysis reveals CAF-induced colorectal cancer immune remodeling mechanism
- Principal Investigator
  
  SADA Masafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis of biological significance of FAM115c for development of a new therapeutic strategy of lung NET
- Principal Investigator
  
  永井俊太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
Elucidation of diversity and novel roles of APCs in the cancer microenvironment by scRNAseq with spatial gene expression analysis
- Principal Investigator
  
  OHUCHIDA Kenoki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Classification of pancreatic ductal adenocarcinoma based on niche factor dependency with single cell analysis and organoidPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Kei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of a new therapy of lung NET by inhibiting protein tyrosine phosphatase H1 (PTPH1)
- Principal Investigator
  
  Nakamura Katsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
Development of a new therapeutic strategy regulated Treg cells targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)
- Principal Investigator
  
  NAGAMI Masayo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University
Development of new therapeutic strateg for pancreatic cancer targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)
- Principal Investigator
  
  YANAI Kosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
The regulation of cancer recurrence by the construction of immunosurveilance targeing cell cycle withdrawal/reentry cancer cell
- Principal Investigator
  
  ONISHI Hideya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Elucidation and control of the mechanism of cluster invasion by partialEMT using pancreatic cancer organoids
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Development of new therapeutical strategy for gallbladder cancer targeting Gli2 signaling pathway
- Principal Investigator
  
  YAMASAKI Akio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of therapy for inhibition of fibrosis of schirrhous type gastric cancer using Hh inhibitor aiming establishment of immunosurveilance
- Principal Investigator
  
  NAGAI Shuntaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of new therapeutical strategy for lung NET by inhibiting Hh/Notch signaling targeting RBPJ
- Principal Investigator
  
  MORISAKI Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
Clarification and control of immune cell-induced PSC substrate remodeling using KPCL mice
- Principal Investigator
  
  ONIMARU Manabu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Cellular clearance leading to peritoneal dissemination of pancreatic cancer and a new role of peritoneal mesothelium -From defense to promotion-
- Principal Investigator
  
  INOUE Shigetaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Elucidating the mechanisms of pre-metastatic niche formation by pancreatic cancer exosomesPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Kei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University
Analysis of TrkB/BDNF-Hh crosstalk pathway for development of therapeutic strategy against lung NET
- Principal Investigator
  
  NAKAMURA Katsuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyushu University
Identification of the organ-specific cancer leading cells and regulation of the tumor micro-environment remodeling which leads to cancer cell metastasis.
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Tropomyosin-related kinase B is a biomarker of prognosis and therapeutic target for malignant thymic epithelial tumors2022
- Author(s)
  Ozono K, Onishi H, Iwamoto N, Nakamura K, Miyoshi K, Nakamura M, Oda Y
- Journal Title
  
  Anticancer Res
  
  Volume: 42 Issue: 8 Pages: 3779-3787
- DOI
  10.21873/anticanres.15868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08673, KAKENHI-PROJECT-21K08712, KAKENHI-PROJECT-21K08906, KAKENHI-PROJECT-22K08715, KAKENHI-PROJECT-20K09180, KAKENHI-PROJECT-23K24422
[Journal Article] PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor2021
- Author(s)
  Koga S, Onishi H, Masuda S, Fujimura A, Ichimiya S, Nakayama K, Imaizumi A, Nishiyama K, Kojima M, Miyoshi K, Nakamura K, Umebayashi M, Morisaki T, Nakamura M
- Journal Title
  
  Transl Oncol
  
  Volume: 14(9) Issue: 9 Pages: 101152-101152
- DOI
  10.1016/j.tranon.2021.101152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09047, KAKENHI-PROJECT-19K09124, KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-20K09180, KAKENHI-PROJECT-21K08672, KAKENHI-PROJECT-21K09583
[Journal Article] S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer2019
- Author(s)
  Nakayama H, Ohuchida K, Yonenaga A, Sagara A, Ando Y, Kibe S, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Shido K, Miyoshi K, Nakata K, Moriyama T, Miyasaka Y, Inoue S, Ohtsuka T, Mizumoto K, Nakamura M
- Journal Title
  
  Int J Oncol
  
  Volume: 55 Pages: 211-222
- DOI
  10.3892/ijo.2019.4812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02881, KAKENHI-PROJECT-17K10700
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08620
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08788
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K22662
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09124
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09047
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規小細胞肺癌治療の開発2020
- Author(s)
  古賀智子、大西秀哉、三好圭、大山康博、中山和典、一宮　脩、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08682
[Presentation] TrkBシグナルとHedgehogシグナルの負のクロストークを考慮した小細胞肺癌に対する新たな治療法の開発2018
- Author(s)
  大西秀哉、中村勝也、梁井公輔、川元　真、大山康博、中山和典、山崎章生、三好　圭、中村雅史
- Organizer
  第118回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08620
[Presentation] TrkBシグナルとHedgehogシグナルの負のクロストークを考慮した小細胞肺癌に対する新たな治療法の開発2018
- Author(s)
  大西秀哉、中村勝也、梁井公輔、川元　真、大山康博、中山和典、山崎章生、三好　圭、中村雅史
- Organizer
  第118回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10792

1. ONISHI Hideya (30553276)

# of Collaborated Projects: 11 results

# of Collaborated Products: 10 results
2. NAGAI Shuntaro (90755240)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
3. OHUCHIDA Kenoki (20452708)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
4. YAMASAKI Akio (80404440)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
5. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
6. SADA Masafumi (10783508)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAKAMURA Katsuya (60585743)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. MORISAKI Takashi (90291517)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. YANAI Kosuke (10621055)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 宮坂義浩 (40507795)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
11. 森山大樹 (70586859)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. 寅田信博 (00398075)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. 今泉晃 (30624051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. NAGAMI Masayo (80792209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 進藤幸治 (00788432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 藤田逸人 (40611281)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. ONIMARU Manabu (80529876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. INOUE Shigetaka (00529802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. HORIOKA Kohei (10783699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大塚隆生 (20372766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 江口大樹 (90726390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 江上拓哉 (40507787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 岩本千佳 (10752842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 水元一博 (90253418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 甲斐昌也 (10755242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 木庭遼 (10866776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 小薗真吾 (40706850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 永吉絹子 (90761015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 仲田興平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyoshi Kei 三好 圭

MIYOSHI Kei 三好 圭

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網羅的解析による膵癌免疫抑制環境メカニズムの解明Principal Investigator

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Classification of pancreatic ductal adenocarcinoma based on niche factor dependency with single cell analysis and organoidPrincipal Investigator

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Miyoshi Kei 三好圭

MIYOSHI Kei 三好圭