OKUMURA Yutaka 奥村寛

… Alternative Names

奥村寛オクムラユタカ

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Researcher Number	00073130
Other IDs
Affiliation (based on the past Project Information) *help	2003 – 2005: Nagasaki University, Graduated School of Biochemical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 2002: 長崎大学, 医学部, 助手 1988 – 2002: 長崎大学, 医学部, 教授 1992: 長崎大, 医・後障研, 教授 1992: Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 教授 1992: 長崎大学, 医学部原爆資料センター, 教授 1986: 長崎大, 医学部, 助教授
Review Section/Research Field	Principal Investigator Radiation science / Radiation science Except Principal Investigator Biological Sciences / 環境影響評価(含放射線生物学) / Radiation science / 医学一般 / 環境生理学(含体力医学･栄養生理学) / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator RBE / ハイパーサーミア / 癌治療 / 熱耐性 / 温熱処理 / 細胞致死 / 放射線照射 / scid細胞 / 放射線感受性 / 重粒子線 … More / DNA二重鎖切断 / DNA-PK活性 / heavy ion particles / radiosensitivity / DNA double strand breaks / DNA-PK activity / scid cells / FAK / ERK / p53 / ミトコンドリア / 体温調節 / 化学療法 / 温熱療法 / 加熱処理 / 温熱増感効果 / 癌遺伝子 / 熱感受性 / NIH3T3細胞 / Oncogene / Thermosensitivity / NIH3T3 Cells / DNAニ重鎖切断 / DNA二重鎖 / 細胞運動性 / がん転移 / X線 / インテグリン / ラミニン / 癌転移 / 細胞外マトリックス / 神経膠芽腫細胞 / P53 / cell mobility / metastasis / X-ray / integrin / laminin … More Except Principal Investigator p53 / 放射線感受性 / DNA-PK / 温熱感受性 / 放射線 / 癌治療 / 放射線耐性 / アポトーシス / 温熱療法 / 遺伝子導入 / Ku70 / HSP72 / 変異部位 / スクリーニング / 制癌剤 / DNA修復 / 放射線治療 / accelerated aging / シグナル伝達 / signal transduction / 80 / 温熱処理 / 熱ショック蛋白質 / Ku80 / HSC73 / ATM / MTF-1 / XRCC / 一過性骨髄異常増殖症 / 発生機構 / ダイソミー性ホモ接合性 / がん関連遺伝子 / 変異遺伝子の量的効果 / 染色体異型 / RFLP / 21番染色体の過剰 / 毛細血管拡張性運動失調症 / 11番染色体 / 染色体移入 / 放射線抵抗性DNA合成 / 癌細胞 / 癌遺伝子 / 癌抑制遺伝子 / ヒートショックタンパク質 / scidマウス / アタキシアーテランジェクタシア / 遺伝子マッピング / P53 / 先行指導 / NBS1 / 放射線誘導タンパク / 細胞死(アポトーシス) / 感受性修飾 / 先行指標 / DNA・PK / リン酸化・脱リン酸化 / Saos-2 / 放射線加齢 / 血清成分 / 時系列変化 / 老化促進モデルマウス / 加齢 / 線形モデル / 時系列 / SAM / radiation-induced aging / serum components / time series changes / senescence accelerated mouse / 温熱耐性 / ニューロ・ペプタイド / サイトカイン / ニューロテンシン / ボンベシン / インターロイキン1αβ / 熱ショック蛋白 / 温度修飾因子 / 熱耐性 / 熱感受性 / 温熱細胞性免疫 / 発熱・解熱 / 寒冷・暑熱適応機序 / 体温調節機序 / SDS-PAGE,Western,Northan blotting / Thermosensitivity / thermotolerance / neuro-peptides / cytokine / neurotensin / Bombesin / IL-1alpha beta / heat shock protein(HSP) / 突然変異 / シグナルトランスダクション / Saos2 / G1停止 / SaOS-2 / mutation / radio-sensitivity / apoptosis / transduction / DNA二本鎖切断 / DNA-PK活性 / DNA二本鎖切断の修復 / X線 / DNA double strand break / Heat treatment / 熱失活の回復 / Heat shock protein / Recovery of hea-inactivation / Heat shock Protein / 環境ストレス / クロストーク / 放射線応答 / リン酸化 / 環境ストレ / environmental stress / crosstalk / radiation response / phosphorylation / 甲状腺 / 細胞周期 / MDM2 / 甲状腺がん / thyroid / radiation / DNA repair / cell cycle Less

Study of Involvement of DNA Repair in Radiation Induced Thyroid Cancer
- Principal Investigator
  
  ASHIZAWA Kiyoto
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Radiation Effects Research Foundation
Effect of X-ray irradiation on tumor metastasisPrincipal Investigator
- Principal Investigator
  
  MATSUDA Naoki, 奥村寛
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
各種変異p53遺伝子導入細胞のマイクロプレートによる放射線・制癌剤感受性の測定
- Principal Investigator
  
  岡市協生
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Crosstalk of signal transduction of p53 by various stress from environments
- Principal Investigator
  
  OKAICHI Kumio
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Nagasaki University
各種変異p53遺伝子導入細胞による放射線治療と制癌剤のスクリーニングシステム
- Principal Investigator
  
  岡市協生
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Role of heat shock protein (HSP) for the recovery of heat-inactivated DNA-PK
- Principal Investigator
  
  MAKOTO Ihara
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
各種変異p53遺伝子導入細胞による放射線治療と制癌剤のスクリーニングシステム
- Principal Investigator
  
  岡市協生
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Radiosensitivity of Scid Cells Deficient in Repair of DNA Damages Induced by High LET IrradiationPrincipal Investigator
- Principal Investigator
  
  OKUMURA Yutaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
放射線感受性予測の基礎研究
- Principal Investigator
  
  鈴木紀夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
p53の変異部位に対応した放射線による癌治療法の開発
- Principal Investigator
  
  岡市協生
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagasaki University
Relationship between DNA double strand break repair and DNA-PK activity
- Principal Investigator
  
  IHARA Makoto
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
p53の変異部位に対応した放射線による癌治療法の開発
- Principal Investigator
  
  OKAICHI Kumio
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
Radiosensitivity of scid cells for heavy ion particlesPrincipal Investigator
- Principal Investigator
  
  OKUMURA Yutaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  NAGASAKI UNIVERSITY
The changes of radio-sensitivity and signal transduction by mutation in p53
- Principal Investigator
  
  OKAICHI Kumio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Nagasaki University
癌関連遺伝子を標的とする遺伝操作による温熱感受性の制御
- Principal Investigator
  
  大西武雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Medical University
Analysis of Thermotolerance of Cancer by Introduction of OncogegesPrincipal Investigator
- Principal Investigator
  
  OKUMURA Yutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
癌関連遺伝子からみた温熱療法抵抗性癌の細胞特性
- Principal Investigator
  
  大西武雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Medical University
癌関連遺伝子からみた温熱療法抵抗性癌の細胞特性
- Principal Investigator
  
  大西武雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nara Medical University
癌関連遺伝子からみた温熱抵抗性癌の細胞持性
- Principal Investigator
  
  大西武雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nara Medical University
V(D)Jリコンビネース欠損突然変異を用いたDNA修復機序の解析
- Principal Investigator
  
  小松賢志
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University
Research project on the varient modification of thermosensitivity in the
- Principal Investigator
  
  KOSAKA Mitsuo
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  環境生理学(含体力医学･栄養生理学)
- Research Institution
  Institute of Tropical Medicine, Nagasaki University
Study on quantification of radiation-induced aging by linear model
- Principal Investigator
  
  KONDO Hisayoshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Nagasaki University
DNA修復能力と毛細血管拡張性運動失調症(AT)形質発現の解析
- Principal Investigator
  
  小松賢志
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University
一過性骨髄異常増殖症(TAM)の発生機構
- Principal Investigator
  
  新川詔夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University
動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator
- Principal Investigator
  
  奥村寛
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University
動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator
- Principal Investigator
  
  奥村寛
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University
動物腫瘍系における温熱の制癌効果を左右する因子とその修飾に関する研究Principal Investigator
- Principal Investigator
  
  奥村寛
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagasaki University

All 2006 2004 2003 2002

All Journal Article

[Journal Article] Sucralfate Protects Intestinal Epithelial Cells From Radiation-Induced Apoptosis in Rats.2006
- Author(s)
  Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K, Ishii, K., Wen, CY, Fukuda, E., Nakayama, T., Nakashima, M., Okumura, Y., Sekine, I.
- Journal Title
  
  J.Radiat.Res. 47
  
  Pages: 1-8
- NAID
  110004701145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] 癌細胞で見つかる各種変異p53シグナルの放射線感受性への関与2006
- Author(s)
  岡市協生, 井手美和, 奥村寛
- Journal Title
  
  広島医学印刷中
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] Hypergravity induces phosphorylation of p53 at serine 15 but not expression of p53-downstream genes.2004
- Author(s)
  Okaichi, K, Ide, M., Usui, A., Okumura, Y.
- Journal Title
  
  J.Radiat.Res. 45
  
  Pages: 399-403
- NAID
  110004041041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] Radiation sensitivity and mutation position of p53.2003
- Author(s)
  Okaichi, K., Ide, M., Okumura, Y.
- Journal Title
  
  Radiation and Humankind, Elsevier Science,(Shibata, Y., Yamashita, S., Watanabe, M., Tominaga, M.(eds))
  
  Pages: 239-243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] Low dose of wortmannin reduces radiosensitivity of cells.2002
- Author(s)
  Okaichi, K., Suzuki, K., Morita, N., Ikeda, M., Matsuda, N., Takahashi, H., Watanabe M., Okumura, Y.
- Journal Title
  
  Radiation and Homeostasis, Elsevier Science (Sugahara, T., Nikaido, O., Niwa, O.(eds))
  
  Pages: 359-362
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway.2002
- Author(s)
  Okaichi, K., Suzuki, K., Morita, N., Ikeda, M., Takahashi, H., Matsuda, N., Watanabe M., Okumura, Y.
- Journal Title
  
  Oncol.Rep. 9
  
  Pages: 859-862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255
[Journal Article] Hypergravity modified the signal transduction of ionizing radiation through p53.2002
- Author(s)
  Okaichi, K., Usui, A., Ohnishi, T., Okumura, Y.
- Journal Title
  
  J.Radiat.Res. 43
- NAID
  110002328993
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380255

1. IHARA Makoto (60175213)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. OKAICHI Kumio (80124874)

# of Collaborated Projects: 10 results

# of Collaborated Products: 7 results
3. KANO Eiichi (70065910)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. 大西武雄 (60094554)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. 鈴木紀夫 (10010050)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. KOSAKA Mitsuo (30079983)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. 小松賢志 (80124577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 渡辺正己 (20111768)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 川崎祥二 (20034952)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 田中紀元 (20079932)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. SIMASAKI Tatsuya (60264248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MATSUDA Naoki (00304973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 田中敬正 (40131445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 中村弥

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. KONDO Hisayoshi (00170431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MINE Mariko (00108292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISEKI Masachika (50176252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KISHIKAWA Masao (80112374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAGASAKA Tetsuo (80023646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. IRIKI Masami (90072967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KUROSHIMA Akihiro (90002774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TAKESHITA Satoshi (20295083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MORITA Naoko (90380972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ASHIZAWA Kiyoto (10304932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NANBA Hiroyuki (80237635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 新川詔夫 (00111170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 陣野吉廣 (20179097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 辻芳郎 (30039812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 児玉靖司 (00195744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 上田公介 (20128648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 豊島宗厚 (10155533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 渡辺直樹 (10158644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 平岡真寛 (70173218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 小川恭弘 (90152397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 森弘行 (30128227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 山下俊一 (30200679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 中村彌

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKUMURA Yutaka 奥村 寛

奥村 寛 オクムラ ユタカ

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Effect of X-ray irradiation on tumor metastasisPrincipal Investigator

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Radiosensitivity of Scid Cells Deficient in Repair of DNA Damages Induced by High LET IrradiationPrincipal Investigator

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Radiosensitivity of scid cells for heavy ion particlesPrincipal Investigator

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Analysis of Thermotolerance of Cancer by Introduction of OncogegesPrincipal Investigator

OKUMURA Yutaka 奥村寛

奥村寛オクムラユタカ