NEMOTO Nobuo 根本信雄

… Alternative Names

根本信雄ネモトノブオ

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Researcher Number	10085631
Affiliation (based on the past Project Information) *help	2008 – 2010: 富山大学, 大学院・医学薬学研究部(薬学), 教授 2008: University of Toyama, 大学院・大学院医学薬学研究部(薬学), 教授 2007 – 2008: University of Toyama, 医学薬学研究部(薬学), 教授 1998 – 2004: 富山医科薬科大学, 薬学部, 教授 1996: 富山医科薬科大学, 薬学部, 教授 … More 1994 – 1995: 癌研究会癌研究所, 実験病理部, 主任研究員 1993: (財)癌研究会, 癌研究所・実験病理部, 主任研究員 1992: 癌研究会, 癌研究所・実験病理部, 主任研究員 1992: 癌研究所, 主任研究員 1991: 癌研究会癌研究所, 主任研究員 1988 – 1989: 癌研究会, 癌研究所・実験病理部, 研究員 1988: 癌研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Environmental pharmacy / Medical pharmacy Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator CYP2B / 性ホルモン / 肝細胞初代培養系 / 副腎皮質ホルモン / 成長ホルモン / シトクロムP450 / Growth hormone / Sex hormone / フェノバルビタール / ヘテロサイクリックアミン … More / チトクロームP-450 / Hypophytectomy / Dexamethasone / Glucocorticoid / マウス / 脳下垂体摘出 / デキサメタゾン / Phenobarbita / Phenobarbital / Glucocorticoid hormone / マウス肝細胞初代培養系 / 遺伝子の発現制御 / 発癌物質の代謝 / HNF3β(FoxA2) / CYP2B9 / シグナル伝達 / 薬物代謝 / 初期肝細胞培養系 / チトクロームP450 / 発がん物質の代謝 … More Except Principal Investigator Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / ヒトのRFLP / シグナル認識粒子 / 酵素誘導 / 誘導剤と結合する受容体 / 遺伝子転写制御領域 / 癌原性化学物質への感受性 / ハムスター肺P450 / チトクロームP450mRNA / チトクロームP450遺伝子 / 性特異性 / シトクロムP450 / マウス / 性差 / 発現制御 / CYP3A / 薬物代謝酵素 / 発がん性 / 酸化的ストレス / DNA付加体 / 遺伝子変異 / ニトロソ化合物 / 変異原性 / ヘテロサイクリックアミン / 環境因子 / 発がんリスク評価 / 突然変異 / DNA修復 / DNA損傷 / 細胞回転 / 発癌物質 / 発癌と環境因子 / 発癌と宿主因子 / イニシエ-ション Less

Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mouse
- Principal Investigator
  
  SAKUMA Tsutomu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Sex-dependent expression mechanism of cytochrome P450 by growth hormone and a transcription factor, HNF3β or HNF4αPrincipal Investigator
- Principal Investigator
  
  NEMOTO Nobuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Collaborating interaction of hormones for sex-dependent expression of CYP2B familyPrincipal Investigator
- Principal Investigator
  
  NEMOTO Nobuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Different expression mechanism of CYP2B subfamilies by phenobarbital and glucocorticoid hormonePrincipal Investigator
- Principal Investigator
  
  NEMOTO Nobuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Analysis of sex hormone-responsive element in sexually dimorphicly expressing CYP2B subfamily genePrincipal Investigator
- Principal Investigator
  
  NEMOTO Nobuo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
環境因子の発がんリスク評価
- Principal Investigator
  
  福島昭治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka City University
ヘテロサイクリックアミン等の代謝活性化に関与するP450IA2の発現制御機構Principal Investigator
- Principal Investigator
  
  根本信雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
ヘテロサイクリックアミン等の代謝活性化に関与するP450IAの発現制機構Principal Investigator
- Principal Investigator
  
  根本信雄
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
宿主・臓器環境とイニシエ-ションリスクの変動
- Principal Investigator
  
  石川隆俊
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Information Exchange on Cancer Research with North American Countries.
- Principal Investigator
  
  YAMAGUCHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo
発癌物質に抵抗性及び感受性動物の代謝活性化系の発現制御Principal Investigator
- Principal Investigator
  
  根本信雄
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
癌原性化学物質への感受性に関するチトクロームPー450遺伝子の発現とその調節
- Principal Investigator
  
  渡辺民朗
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
発癌物質に抵抗性及び感受性動物の代謝活性化系の発現制御Principal Investigator
- Principal Investigator
  
  根本信雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

All 2011 2010 2009 2008 2007 2004

All Journal Article Presentation

[Journal Article] Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes2011
- Author(s)
  Kondo S., Chatuphonprasert W., Jaruchotikamol A., Sakuma T., Nemoto N.
- Journal Title
  
  Toxicology 280
  
  Pages: 18-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Hepatocyte nuclear factor 4 alpha regulates expression of the mouse female-specific Cyp3a41 gene in the liver.2011
- Author(s)
  Bhadhprasit W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Drug Metab. Dispos. 39
  
  Pages: 490-497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Regulatory xenobiotic responsive elements in the distal 5'-flanking region of the mouse Cypla2 gene required for transcriptional activation by 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.2010
- Author(s)
  Kawasaki Y., Sakuma T., Goto Y., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 38
  
  Pages: 1640-1643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Potent modification of inducible CYP1A1 expression by flavonoids.2010
- Author(s)
  Chatuphonprasert W., Kondo S., Jarukamjorn K., Kawasaki Y., Sakuma T., Nemoto N.
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 1698-1703
- NAID
  130000402364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver.2010
- Author(s)
  Jarukamjorn K., Kondo S., Chatuphonprasert W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Eur.J.Pharm.Sci. 39
  
  Pages: 394-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Alteration of acetaminophen-induced cytotoxicity in mouse hepatocytes during primary culture.2009
- Author(s)
  Jaruchotikamol A, Takase A, Ito S, Kawasaki Y., Kondo S, Sakuma T., Nemoto N.
- Journal Title
  
  J.Health Sci. 55
  
  Pages: 767-776
- NAID
  130000127965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent Andrographolide.2008
- Author(s)
  Jarukamjorn K., Nemoto N.
- Journal Title
  
  J. Health Sci. . 54
  
  Pages: 370-381
- NAID
  110006835682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Conjugates of p-hydroxymethamphetamine and 4-hydroxy-3-methoxymethamphetamine in blood obtained from methamphetamine and 3, 4-methylenedioxymethamphetamine users : analysis by LC-MS-MS.2008
- Author(s)
  Shima N., Katagi M., Kamata H., Zaitsu K., Kamata T., Miki A., Tsuchihashi H., Sakuma T., Nemoto N.
- Journal Title
  
  Forensic Toxicol. 26
  
  Pages: 58-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma T, Bhadhprasit W, Hashita T, and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent Andrographolid2008
- Author(s)
  Jarukamjorn K, and Nemoto N
- Journal Title
  
  J. Health Sci 54
  
  Pages: 370-381
- NAID
  110006835682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression.2008
- Author(s)
  Sakuma T., Bhadhprasit W., Hashita T., Nemoto N.
- Journal Title
  
  Drug Metab.Dispos. 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.2008
- Author(s)
  Hashita T., Sakuma T., Akada M., Nakajima A., Yamahara H., Ito S., Takesako H., Nemoto N.
- Journal Title
  
  Drug Metab. Dispos. 35
  
  Pages: 1080-1087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression2008
- Author(s)
  Sakuma T., Bhadhprasit W., Hashita T., Nemoto N
- Journal Title
  
  Drug Metab. Dispos. . 36
  
  Pages: 878-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes2008
- Author(s)
  Jaruchotikamol A., Jarukamjorn K, Sirisangtrakul W, Sakuma T, Kawasaki Y, and Nemoto N
- Journal Title
  
  Toxicol. Appl. Pharmacol 224
  
  Pages: 156-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W., Sakuma T., Hatakeyama N., Fuwa M., Kitajima K., Nemoto N.
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 1880-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W, Sakuma T, Hatakeyama N, Fuwa M, Kitajima K, and Nemoto N.
- Journal Title
  
  Drug Metab. Dispos 35
  
  Pages: 1880-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Strong synergistic induction of CYP1A1 expression by androgra-pholide plus typical CYP1A inducers in mouse hepatocytes2007
- Author(s)
  Jaruchotikamol A., Jarukamjorn K., Sirisangtrakul W., Sakuma T., Kawasaki Y., Nemoto N.
- Journal Title
  
  Toxicol. Appl. Pharmacol 224
  
  Pages: 156-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Direct determination of glucuronide and sulfate of 4-hydroxy-3-methoxymethamphetamine,the main metabolite of MDMA,in human urine2007
- Author(s)
  Shima N., Kamata H., Katagi M., Tsuchihashi H., Sakuma T., Nemoto N.
- Journal Title
  
  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci 857
  
  Pages: 123-129
- NAID
  10025808869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590140
[Journal Article] Involvement of mitogen-activated protein kinase and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.....2004
- Author(s)
  Miyahara T et al.(with Nemoto N)
- Journal Title
  
  Toxicology 200
  
  Pages: 159-167
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones.2004
- Author(s)
  Sakuma T, et al.(with Nemoto N)
- Journal Title
  
  Biochem.Biophys.Research Commun. 314
  
  Pages: 495-500
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones.2004
- Author(s)
  Sakuma T, et al.(with Nemoto N)
- Journal Title
  
  Biochem.Biophys.Research Commun. 323
  
  Pages: 776-781
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones2004
- Author(s)
  Sakuma T, Kitajima K, Nishiyama M, Mashino M, Hashita T, Nemoto N
- Journal Title
  
  Biochem Biophys Res Commun. 323(3)
  
  Pages: 776-781
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.2004
- Author(s)
  Miyahara T et al.(with Nemoto N)
- Journal Title
  
  Toxicology 200
  
  Pages: 159-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Collaborated regulation of female-specific murine Cyps3a41 gene expression by growth and glucocorticoid hormones.2004
- Author(s)
  Sakuma T, Kitajima K, Nishiyama M, Endo Y, Miyauchi K, Jarukamjorn K, Nemoto N.
- Journal Title
  
  Biochem Biophys Res Commun. 314(2)
  
  Pages: 495-500
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Journal Article] Involvement of mitogen-activated protein kitnases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.2004
- Author(s)
  Miyahara T, Katoh T, Watanabe M, Mikami Y, Uchida S, Hosoe M, Sakuma T, Nemoto N, Takayama K, Komurasaki T.
- Journal Title
  
  Toxicology 200(2-3)
  
  Pages: 159-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590125
[Presentation] マウスCyp3a41遺伝子構造とHNF4αによる性特異的発現2010
- Author(s)
  佐久間勉, 池松怜美, Bhadhprasit Wattanaporn, 河崎優希, 根本信雄
- Organizer
  日本薬学会北陸支部第122回例会
- Place of Presentation
  金沢
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Regulatory XREs in distal 5'-flanking region of the mouse Cypla2 gene for transcriptional activation by 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.2010
- Author(s)
  Kawasaki Y., Yuma Goto, Sakuma T., Nemoto N.
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Role of hepatocyte nuclear factor 4 alpha and chromatin structure in the regulation of female-specific Cyp3a41 gene expression.2010
- Author(s)
  Sakuma T., Bhadhprasit W., Kawasaki Y., Nemoto N.
- Organizer
  18th International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] Cyp3a41遺伝子メス特異的発現の調節機構2010
- Author(s)
  佐久間勉, Bhadhprasit Wattanaporn, 河崎優希, 近藤佐千子, 根本信雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メスマウス肝でのCyp3a41遺伝子発現におけるクロマチン構造とHNF4αの役割2010
- Author(s)
  佐久間勉, 池松怜美, Bhadhprasit Wattanaporn, 河崎優希, 近藤佐千子, 根本信雄
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の発現調節機構:Glucocoeticoid receptorおよびHepatocyte nuclear factor-4αの役割2009
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 河崎優希, 根本信雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] 12のXを含むCyp1a2遺伝子の5'上流域による3-MC並びに2,3,7,8-TCDD誘導性マウスCyp1a2遺伝子転写調節2009
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の調節機構:C/EBPの役割2008
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 赤田真美, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之, 上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involvement of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Wattanaporn Bhadhprasit^*, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] グルココルチコイドによるCyp3a41遺伝子の調節機構 : C/EBPの役割2008
- Author(s)
  Wattanaporn Bhadhprasit, 佐久間勉, 赤田真美, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之, 上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involve-ment of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Wattanaporn Bhadhprasit, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Cypla2遺伝子5'上流域による3-メチルコラントレン並びに2, 3, 7, 8-TCDD誘導性マウスCypla2遺伝子転写調節2008
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] アンドログラフォリドによる3-メチルコラントレン誘導性CYP1A1遺伝子ファミリー発現の促進と性差2008
- Author(s)
  近藤佐千子, Kanokwan Jarukamjorn, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] マウスCyp3a41の性特異的発現におけるHNF4αの役割2008
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, Bhadhprasit Wattanaporn, 坡下真大, 根本信雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] メス優位に発現するマウスCyp3a41遺伝子転写過程におけるHNF4αの役割2008
- Author(s)
  根本信雄, 古澤裕之,上野真一, 佐久間勉
- Organizer
  第15回肝細胞研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] 12のXREを含むCypla2遺伝子の5'上流域による3-MC並びに2, 3, 7, 8-TCDD誘導性マウスCypla2遺伝子転写調節.2008
- Author(s)
  河崎優希, 佐久間勉, 根本信雄
- Organizer
  第81回日本生化学会大会・第31回日本分子生物学会年会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Glucocorticoid-mediated induction of mouse Cyp3a41 gene expression ; involvement of glucocorticoid receptor and hepatocyte nuclear factor 4 alpha2008
- Author(s)
  Bhadhprasit Wattanaporn, 佐久間勉, 根本信雄
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20590140
[Presentation] マウスメス特異的Cyp3a41遺伝子の常在的発現機構のHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, ペットパラシットワッタナポン, 坡下真大, 宮内希弥子, 阿部かおる, 向井恭行, 根本信雄
- Organizer
  日本薬学会北陸支部第117回例会
- Place of Presentation
  金沢
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Cyp2b9 遺伝子の性依存的転写活性における調節領域の同定2007
- Author(s)
  坡下真大, 中島明日香, 赤田真美, 佐久間勉, 根本信雄
- Organizer
  日本薬学会127 年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス肝臓における Cyp3a41遺伝子の常在的発現に対するHNF4αの役割.2007
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, ペットパラシットワッタナポン, 坡下真大, 阿部かおる, 根本信雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス肝臓におけるCyp3a41遺伝子の常在的発現に対するHNF4αの役割2007
- Author(s)
  古澤之裕, 佐久間勉, 上野真一, ペットパラシットワッタナポン, 坡下真大, 阿部かおる, 根本信雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse Cyp3a44 gene expression by glucocorticoid hormone2007
- Author(s)
  Bhadhprasit W, Sakuma T, and Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス特異的Cyp3a 遺伝子の発現調節2007
- Author(s)
  佐久間勉, Bhadhprasit W, 根本信雄
- Organizer
  第5回ながの遺伝子発現調節研究会
- Place of Presentation
  諏訪
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] 表面汚染モニタリングのための拭き取り効率の検討.2007
- Author(s)
  Sakuma T., Bhadhprasit W., Nemoto N, :
- Organizer
  日本放射線安全管理学会第6回学術大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Involvement of glucoconicoid receptor and pregnane X receptor in theregulation of mouse Cyp3a44 gene expression by glucocor-ticoid hormone.2007
- Author(s)
  Bhadhprasit W., Sakuma T., Nemoto N.
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Trp-P-1の肝毒性に対するepigallocatechin gallate (EGCG)の抑制効果.2007
- Author(s)
  亀井美穂, Jaruchotikamol A., 河崎優希, 根本信雄
- Organizer
  日本薬学会北陸支部第117回例会
- Place of Presentation
  金沢
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers.2007
- Author(s)
  Sakuma T., Bhadhprasit W., Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] メスマウス特異的Cyp3a遺伝子の発現調節.2007
- Author(s)
  佐久間勉, Bhadhprasit W., 根本信雄
- Organizer
  第5回ながの遺伝子発現調節研究会
- Place of Presentation
  諏訪
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] Growth hormone-mediated expression of female-specific Cyp3a44 gene in mouse livers2007
- Author(s)
  Sakuma T, Bhadhprasit W, and Nemoto N
- Organizer
  8th International ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19590140
[Presentation] マウスメス特異的Cyp3a41遺伝子の常在的発現機構のHNF4αの役割.2007
- Author(s)
  古澤之裕, 佐久間勉, ペットパラシットワッタナポン, 披下真大, 宮内希弥子, 阿部かおる, 向井恭行, 根本信雄
- Organizer
  日本薬学会北陸支部第117回例会
- Place of Presentation
  金沢
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19590140

1. SAKUMA Tsutomu (30250468)

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2. KAWASAKI Yuki (30432107)

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3. YAMAGUCHI Nobuo (90012723)

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58. TSUKUMA Hideaki

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NEMOTO Nobuo 根本 信雄

根本 信雄 ネモト ノブオ

Research Projects

Research Products

Co-Researchers

Mechanisms of female-specific expression of drug-metabolizing enzyme CYP3A : comparison between human and mouse

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Sex-dependent expression mechanism of cytochrome P450 by growth hormone and a transcription factor, HNF3β or HNF4αPrincipal Investigator

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Collaborating interaction of hormones for sex-dependent expression of CYP2B familyPrincipal Investigator

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Different expression mechanism of CYP2B subfamilies by phenobarbital and glucocorticoid hormonePrincipal Investigator

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Analysis of sex hormone-responsive element in sexually dimorphicly expressing CYP2B subfamily genePrincipal Investigator

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環境因子の発がんリスク評価

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ヘテロサイクリックアミン等の代謝活性化に関与するP450IA2の発現制御機構Principal Investigator

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ヘテロサイクリックアミン等の代謝活性化に関与するP450IAの発現制機構Principal Investigator

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宿主・臓器環境とイニシエ-ションリスクの変動

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Information Exchange on Cancer Research with North American Countries.

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発癌物質に抵抗性及び感受性動物の代謝活性化系の発現制御Principal Investigator

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癌原性化学物質への感受性に関するチトクロームPー450遺伝子の発現とその調節

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発癌物質に抵抗性及び感受性動物の代謝活性化系の発現制御Principal Investigator

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[Journal Article] Cellular glutathione content modulates the effect of andrographolide on β-naphthoflavone-induced CYP1A1 mRNA expression in mouse hepatocytes2011

Author(s)

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Data Source

[Journal Article] Hepatocyte nuclear factor 4 alpha regulates expression of the mouse female-specific Cyp3a41 gene in the liver.2011

NEMOTO Nobuo 根本信雄

根本信雄ネモトノブオ