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Shimada Yohta  嶋田 洋太

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SHIMADA Yohta  嶋田 洋太

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Researcher Number 20560824
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東京慈恵会医科大学, 医学部, 講師
2010 – 2021: 東京慈恵会医科大学, 医学部, 助教
2014: 東京慈恵会医科大学, 総合医科学研究センター遺伝子治療研究部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
遺伝子治療 / ムコ多糖症II型 / ライソゾーム病 / 先天代謝異常症 / ポンペ病 / ユビキチン化タンパク質 / オートファジー / ユビキチン / 先天異常学 / 遺伝 … More
Except Principal Investigator
… More 遺伝子治療 / ライソゾーム病 / GM1ガングリオシドーシス / AAV / アデノ随伴ウイルスベクター / レンチウイルスベクター / 免疫寛容 / 抗体 / 酵素補充療法 / 腫瘍免疫 / MHCクラスI / 免疫回避機構 / オートファジー / Lysosome酵素 / 膵臓癌 / MPSII / 血液脳関門 / ガラクトシルセラミダーゼ / GM1ガングリオシドーシス / 造血幹細胞 / GM1ガングリオシド―シス / 先天代謝異常学 / 遺伝・先天異常学 / 先天代謝異常 / 先天代謝異常症 / 遺伝・先天異常 / レンチウイルス / イズロン酸サルファターゼ / 骨質系 / 骨芽細胞 / Hunter syndrome / 骨代謝 / 病理 / 骨病変 / ムコ多糖症Ⅱ型 / Krabbe病 / zinc finger / GALC / Zinc Finger / Krabbe病 / 免疫寛容療法 / ポンペ病 / 経口投与 / 抗CD3抗体 / ポンぺ病 / ファブリー病 / ライソゾーム病蓄積症 Less
  • Research Projects

    (14 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (23 People)
  •  血液脳関門を克服するGM1ガングリオシドーシスへの遺伝子治療法の開発

    • Principal Investigator
      角皆 季樹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  細胞送達能向上型酵素を用いたムコ多糖症II型のリンパ球遺伝子治療法開発Principal Investigator

    • Principal Investigator
      嶋田 洋太
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  血液脳関門通過型酵素を搭載したAAVベクターによるライソゾーム病遺伝子治療法の開発

    • Principal Investigator
      松島 小貴
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of lysosome enzymes in pancreatic cancer specific immune evasion system

    • Principal Investigator
      白井 祥睦
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      University of Toyama
  •  BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つか

    • Principal Investigator
      樋口 孝
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  ヒト型受容体介在性トランスサイトーシスを利用したライソゾーム病遺伝子治療法の開発

    • Principal Investigator
      松島 小貴
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Hematopoietic stem cell gene therapy using engineered enzyme with high penetrating ability for mucopolysaccharidosis type IIPrincipal Investigator

    • Principal Investigator
      SHIMADA Yohta
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosis

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

    • Principal Investigator
      Ida Hiroyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases

    • Principal Investigator
      OHASHI TOYA
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Gene Therapy for the Krabbe disease using zinc finger nuclease system

    • Principal Investigator
      KOBAYASHI Hiroshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of enzyme enhancement therapy for Pompe disease by using proteasome inhibitorPrincipal Investigator

    • Principal Investigator
      SHIMADA YOHTA
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of autophagic dysfunction in skeletal muscles from Pompe disease mice by using blood ubiquitin-protein conjugatesPrincipal Investigator

    • Principal Investigator
      SHIMADA Yohta
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine

All 2023 2022 2021 2017 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

  • [Journal Article] A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2023

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Journal Title

      Gene Therapy

      Volume: 30 Issue: 3-4 Pages: 288-296

    • DOI

      10.1038/s41434-022-00357-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Journal Article] Proteasome Inhibitor Bortezomib Enhances the Activity of Multiple Mutant Forms of Lysosomal α-Glucosidase in Pompe Disease2015

    • Author(s)
      Shimada Y, Nishimura E, Hoshina H, Kobayashi H, Higuchi T, Eto Y, Ida H, Ohashi T
    • Journal Title

      JIMD Rep.

      Volume: 18 Pages: 33-39

    • DOI

      10.1007/8904_2014_345

    • ISBN
      9783662448625, 9783662448632
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Patent] 中枢神経系疾患の治療のための、核酸分子、ベクター、組換え細胞及び薬剤2022

    • Inventor(s)
      木下正文、高木春奈、薗田啓之、嶋田洋太、小林博司、他
    • Industrial Property Rights Holder
      JCRファーマ株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-110492
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] 血液脳関門通過型酵素を発現するAAVによるGM1ガングリオシドーシスの遺伝子治療.2023

    • Author(s)
      松島小貴, 飯塚佐代子, 木下正文, 高木春奈, 飯塚俊輔, 樋口孝, 嶋田洋太, 薗田啓之, 大橋十也, 小林博司.
    • Organizer
      第64回日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07808
  • [Presentation] 血液脳関門通過型酵素発現AAVによるライソゾーム病中枢神経症状に対する遺伝子治療.2023

    • Author(s)
      松島小貴, 飯塚佐代子, 木下正文, 高木春奈, 飯塚俊輔, 大月孝太, 今給黎厚志, 樋口孝, 嶋田洋太, 薗田啓之, 大橋十也, 小林博司.
    • Organizer
      第29回日本遺伝子細胞治療学会学術集会.
    • Data Source
      KAKENHI-PROJECT-21K07808
  • [Presentation] Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme.2023

    • Author(s)
      Saki Matsushima, Sayoko Iizuka, Masafumi Kinoshita, Haruna Takagi, Shunsuke Iizuka, Kota Ohtsuki, Atsushi Imakiire, Shinichiro Okamoto, Takashi Nagashima, Takashi Higuchi, Yohta Shimada, Hiroyuki Hioki, Hiroyuki Sonoda, Ayako M. Watabe, Toya Ohashi, Hiroshi Kobayashi.
    • Organizer
      American Society of Gene and Cell Therapy 26th Annual meeting.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07808
  • [Presentation] Application of a novel murine model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2022

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Organizer
      25th Annual Meeting of The American Society of Gene and Cell Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] Gene therapy for GM1 gangliosidosis mediated by AAV vector carrying BBB-penetrable enzyme.2022

    • Author(s)
      Matsushima S, Iizuka S, Kinoshita M, Takagi H, Nagashima T, Shimada Y, Sonoda H, Watabe M. A, Ohashi T, Kobayashi H.
    • Organizer
      第63回日本先天代謝異常学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07808
  • [Presentation] 中枢神経移行型酵素を搭載したAAVによるGM1ガングリオシドーシスへの遺伝子治療2022

    • Author(s)
      松島小貴、飯塚佐代子、木村文香、嶋田洋太、角皆季樹、木下正文、高木春奈、飯塚俊輔、大月孝太、今給黎厚志、樋口孝、薗田啓之、大橋十也、小林博司
    • Organizer
      第28回日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07808
  • [Presentation] Analysis of human hematopoietic stem cell gene therapy using mucopolysaccharidosis type II mice2021

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Ohashi T, Kobayashi H
    • Organizer
      第62回日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] Hematopoietic stem cell gene therapy for mucopolysaccharidosis type II2021

    • Author(s)
      Shimada Y
    • Organizer
      The 27th annual meeting of Japan Society of Gene and Cell Therapy
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017

    • Author(s)
      横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
    • Organizer
      日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Presentation] Development of missense murine model of Pompe disease2015

    • Author(s)
      Shimada Y, Fukuda T, Nishimura E, Hoshina H, Kobayashi H, Higuchi T, Ida H, Ohashi T
    • Organizer
      Annual Symposium of the Society for the Study of Inborn Errors of Metabolism
    • Place of Presentation
      Lyon, France
    • Year and Date
      2015-09-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] 新規ポンペ病モデルマウスを用いたプロテアソーム阻害剤の治療効果の検討2015

    • Author(s)
      嶋田洋太、石井夏実、福田隆浩、保科宙生、樋口孝、小林博司、井田博幸、大橋十也
    • Organizer
      第57回日本先天代謝異常学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] GENE THERAPY FOR KRABBE DISEASE USING THE SYSTEM OF LENTIVIRAL VECTOR AND ZINC FINGER NUCLEASE2014

    • Author(s)
      Hiroshi Kobayashi, Masamichi Ariga, Yohei Sato, Taichi Wakabayashi, Yota Shimada, Takashi Higuchi, Sayoko Iizuka, Yoshikatsu Eto, Toya Ohashi
    • Organizer
      日本遺伝子治療学会
    • Place of Presentation
      東京慈恵会医科大学講堂
    • Data Source
      KAKENHI-PROJECT-24591527
  • [Presentation] Bortezomib enhances the activity and lysosomal trafficking of multiple mutant alpha-glucosidases identified in Pompe disease.2013

    • Author(s)
      Shimada Y, Nishida H, Kobayashi H, Higuchi T, Eto Y, Ida H, Ohashi T
    • Organizer
      The 3rd Asian Congress for Inborn Error of Metabolism
    • Place of Presentation
      舞浜
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] Proteasome inhibitor improves the function and subcellular localization of mutant lysosomal alpha-glucosidase in fibroblasts from patients with Pompe disease.2013

    • Author(s)
      Shimada Y, Nishida H, Kobayashi H, Higuchi T, Eto Y, Ida H, Ohashi T
    • Organizer
      12th International Congress of Inborn Errors of Metabolism
    • Place of Presentation
      Barcelona
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] ポンペ病に対する酵素安定化薬としてのプロテアソーム阻害剤の有効性の検討2012

    • Author(s)
      嶋田洋太、西山由梨佳、小林博司、樋口孝、衞藤義勝、井田博幸、大橋十也
    • Organizer
      第54回 日本先天代謝異常学会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] PO-76. Recombinant lentivirus mediated gene therapy for neonatal mouse model of Krabbe disease2012

    • Author(s)
      Kobayashi H., Shimada Y., Ariga M., Izuka S., Sato Y., Iwamoto T., Fukuda T., Eto Y., Ohashi T.
    • Organizer
      日本遺伝子治療学会
    • Place of Presentation
      熊本テルサ
    • Data Source
      KAKENHI-PROJECT-24591527
  • [Presentation] Proteasome inhibitor improves the function of mutant lysosomal alpha-glucosidase in fibroblasts from Pompe disease patient2012

    • Author(s)
      Yohta Shimada, Hikaru Nishida, Yurika Nishiyama, Hiroshi Kobayashi, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida, Toya Ohashi
    • Organizer
      2nd Asian Congress for Inherited Metabolic Diseases
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-24791089
  • [Presentation] Characterization of ubiquitin-protein conjugates as a blood biomarker for detection of autophagic buildup in Pompe disease mouse2011

    • Author(s)
      Shimada Y, Fukuda T, Nishiyama Y, Kobayashi H, Eto, Y, Ida H, Ohashi T
    • Organizer
      Annual Symposium of Society for the Study of Inborn Errors of Metabolism
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2011-08-31
    • Data Source
      KAKENHI-PROJECT-22791005
  • [Presentation] ポンペ病骨格筋におけるオートファジー異常検出のための血中バイオマーカーとしてのユビキチン化タンパク質の特徴付け2011

    • Author(s)
      嶋田洋太、福田隆浩、西山由梨佳、小林博司、衞藤義勝、井田博幸、大橋十也
    • Organizer
      第16回日本ライソゾーム病研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-29
    • Data Source
      KAKENHI-PROJECT-22791005
  • [Presentation] GeneTherapy for Krabbe disease using the system of lentiviral vector and zinc finger nuclease

    • Author(s)
      Hiroshi Kobayashi、Masamichi Ariga, Yohei Sato, Taichi Wakabayashi, Yota Shimada et al.
    • Organizer
      第20回 日本遺伝子治療学会
    • Place of Presentation
      東京都、慈恵医大講堂
    • Year and Date
      2014-08-06 – 2014-08-08
    • Data Source
      KAKENHI-PROJECT-24591527
  • [Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発

    • Author(s)
      大橋十也 嶋田洋太 樋口孝 飯塚佐代子 井田博幸 衞藤義勝 小林博司
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-13 – 2014-11-15
    • Data Source
      KAKENHI-PROJECT-24591526
  • 1.  KOBAYASHI Hiroshi (90266619)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 13 results
  • 2.  HIGUCHI Takashi (30595327)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 5 results
  • 3.  OHASHI TOYA (60160595)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 4.  松島 小貴 (80451871)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  Ida Hiroyuki (90167255)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MAEDA Kazuhiro (50548849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  衞藤 義勝 (50056909)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  齋藤 充 (50301528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  横井 健太郎 (20459655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  渡部 文子 (00334277)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  福田 隆浩 (60228913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  角皆 季樹 (60816635)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  白井 祥睦 (10785364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  春木 孝一郎 (60720894)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  羽村 凌雅 (60894425)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  谷合 智彦 (60961860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  池上 徹 (80432938)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  古川 賢英 (80624973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  田中 晴祥 (80793504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  柳垣 充 (80979435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  WADA Miho
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KONDO Saki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 23.  衛藤 義勝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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