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OKAMOTO Hiroaki  岡本 宏明

ORCIDConnect your ORCID iD *help
… Alternative Names

岡本 宏明  オカモト ヒロアキ

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Researcher Number 30177092
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2014: 自治医科大学, 医学部, 教授
2010 – 2012: 自治医科大学, 医学部, 教授
2008: Jichi Medical University, 医学部・感染免疫学講座ウイルス学部門, 教授
2007 – 2008: Jichi Medical University, 医学部, 教授
2003 – 2005: JICHI MEDICAL SCHOOL, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 … More
1998 – 2002: 自治医科大学, 医学部, 助教授
1994 – 1997: 自治医科大学, 医学部, 講師
1994 – 1996: 自治医科大学, 講師
1987 – 1988: 自治医科大学, 医学部, 講師
1986: 自治医科大学, 予防生態学, 助手 Less
Review Section/Research Field
Principal Investigator
Virology / Virology
Except Principal Investigator
Virology / Legal medicine / Digestive surgery / Virology
Keywords
Principal Investigator
TTV / 遺伝子型 / 劇症肝炎 / E型肝炎ウイルス / transfection / tandem dimer / mRNA / TTウイルス(TTV) / selective PCR / PCR … More / RT-PCR / HGV / GBV-C / 放出機構 / 感染性cDNAクローン / Genotype / Food-borne transmission / Infectious source / IgA class anti-HEV / ELISA / Zoonosis / Hepatitis E virus / Hepatitis E / 輸血感染 / IgAクラスHEV抗体 / 核酸診断法 / 感染経路 / 食感染 / 感染源 / IgAクラス抗HEV抗体 / ELISA法 / 人畜共通感染症 / E型肝炎 / liver / replicative intermediate / circular single-stranded DNA virus / 好中球 / Transfection / 転写調節機構 / 培養細胞 / RFLP / 骨髄 / 肝臓 / 肺 / 複製中間体 / 1本鎖環状DNAウイルス / Genetic group / phylogenetic tree / Tprque genotype virus / TTウイルス / Neighbor-joining法 / 遺伝子グループ / 分子系統樹 / トークテノウイルス / liver disease / mother-to-infant transmission / genotype / genomic structure / hepatitis G virus / GBウイルスC / 塩基配列 / RT PCR / 3′非翻訳領域 / E2抗体 / 肝癌 / 慢性肝炎 / 肝疾患 / 母児間感染 / 遺伝子構造 / G型肝炎ウイルス / immune electron microscopy / hepatitis C virus core particles / electron microscopy / sucrose density gradient centrifugation / hepatitis C virus / 構造蛋白 / 免疫電顕 / C型肝炎ウイルスコア粒子 / 電子顕微鏡像 / ショ糖密度勾配遠心法 / C型肝炎ウイルス / MVB sorting / Tsg101 / PSAPモチーフ / ORF3蛋白質 / ゲノム変異 / 細胞レセプター候補分子 / 吸着 / 感受性細胞 / 感染性 cDNA クローン / 感染培養系 / ORF2抗原 / 中和抗体 / ORF3抗原 / ORF3欠損変異ウイルス / 蛍光抗体法 / モノクローナル抗体 / 細胞培養 / 分子 … More
Except Principal Investigator
PCR / TTV / E型肝炎ウイルス / 放出 / Blood grouping / Monoclonal antibody / Glycolipid / Glycophorin / Lewis group / MN group / ABO group / 細胞融合法 / 血液型検査 / 赤血球膜抗原 / ルイス式血液型 / モノクローナル抗体 / 人獣血鑑別 / 物体検査 / 血液型物質 / Glycophorin・Glycolipid / 糖鎖構造 / 血液型判定用試薬 / ABO式血液型 / 糖鎖抗原 / Lewis式血液型 / MN式血液型 / 血痕検査 / 種属鑑別 / 血液型判定用抗体 / Monoclonal抗体 / Gene gun / Hydrodynamic DNA injection / KF506 / Non-specific immunosuppressant / DNA vaccine / Liver transplantation / Viral hepatitis / ラット / B型肝炎 / 非特異的免没抑制剤 / 遺伝子銃 / ハイドロダイナミクス法 / FK506 / 非特異的免疫抑制剤 / DNAワクチン / 肝移植 / ウイルス性肝炎 / extrahepatic disease / liver disease / phylogenetic group / genotype / circular single-stranded DNA / TT virus / 遺伝子変異 / TTウイルス抗体 / 塩基配列 / 血清肝炎 / 超可変領域 / DNAウイルス / TTV抗体 / チンパンジー感染実験 / 電子顕微鏡像 / 特発性肺線維症 / TTV DNA量 / 複製中間体 / TTウイルス(TTV) / 肝外疾患 / 肝疾患 / 分子系統樹 / 環状1本鎖DNA / 遺伝子型 / TTウイルス / エンベロープ / エクソソーム分泌経路 / 出芽 / 多胞体 / エクソソーム / ESCRT機構 / MVB経路 / エンドソーム輸送 / Vps4 / Tsg101 / MVB 経路 / 粒子形成 / E 型肝炎ウイルス / 超可変領域(HVR) / 細胞内局在性 / predisposition / HCV遺伝子型 / 癌抑制遺伝子p53 / X遺伝子 / 肝発がん / C型肝炎ウイルス(HCV) / B型肝炎ウイルス(HBV) Less
  • Research Projects

    (13 results)
  • Research Products

    (75 results)
  • Co-Researchers

    (22 People)
  •  Research on mechanism of hepatitis E virus egress utilizing membrane traffic

    • Principal Investigator
      NAGASHIMA Shigeo
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Jichi Medical University
  •  Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

    • Principal Investigator
      NAGASHIMA Shigeo
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Jichi Medical University
  •  Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEVPrincipal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Jichi Medical University
  •  Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEVPrincipal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Jichi Medical University
  •  Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its preventionPrincipal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  Development of genotyping method for TT virus (TTV) and its application to elucidation of pathogenesis.Principal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki, 真弓 忠
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  Analysis of replication and transcription mechanisms in a newly discovered circular, single-stranded DNA virus (TTV)Principal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Jichi Medical University
  •  Development for DNA vaccination against viral hepatitis recurrence after the liver transplantation using gene gun

    • Principal Investigator
      KOBAYASHI Eiji
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Jichi Medical University
  •  Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)

    • Principal Investigator
      MAYUMI Makoto
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  ANALYSIS OF GENOMIC STRUCTURE OF HEPATITIS G VIRUS (GBV-C/HGV) AND DEVELOPMENT OF SENSITIVE DETECTION SYSTEM OF THE VIRAL GENOMEPrincipal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Virology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  肝炎ウイルスの増殖と肝発がん

    • Principal Investigator
      小池 克郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japanese Foundation For Cancer Research
  •  PURIFICATION OF HEPATITIS C VIRUS PARTICLES AND ANALYSIS OF ITS STRUCTURAL PROTEINSPrincipal Investigator

    • Principal Investigator
      OKAMOTO Hiroaki
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  The production of monoclonal antibodies by mouse-mouse hybridoma cell lines and its application against blood grouping of the forensic materials.

    • Principal Investigator
      IKEMOTO Shigenori
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Legal medicine
    • Research Institution
      Jichi Medical School

All 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 症例から学ぶウイルス肝炎の治療戦略2010

    • Author(s)
      岡本宏明(共著)
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines2014

    • Author(s)
      Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
    • Journal Title

      Virus Research

      Volume: 185 Pages: 92-102

    • DOI

      10.1016/j.virusres.2014.03.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
  • [Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies2014

    • Author(s)
      Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
    • Journal Title

      Journal of General Virology

      Volume: 95 Issue: 10 Pages: 2166-2175

    • DOI

      10.1099/vir.0.066910-0

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
  • [Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014

    • Author(s)
      Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
    • Journal Title

      Virus Research

      Volume: 180 Pages: 59-69

    • DOI

      10.1016/j.virusres.2013.12.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860343
  • [Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014

    • Author(s)
      Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
    • Journal Title

      Virus Research

      Volume: 179 Pages: 102-112

    • DOI

      10.1016/j.virusres.2013.10.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860343
  • [Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 22014

    • Author(s)
      Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
    • Journal Title

      Archives of Virology

      Volume: 159 Issue: 5 Pages: 979-991

    • DOI

      10.1007/s00705-013-1912-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
  • [Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014

    • Author(s)
      Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
    • Journal Title

      Hepatology Research

      Volume: 印刷中 Issue: 10

    • DOI

      10.1111/hepr.12216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860343
  • [Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013

    • Author(s)
      Mulyanto
    • Journal Title

      Archives of Virology

      Volume: 158 Issue: 1 Pages: 87-96

    • DOI

      10.1007/s00705-012-1462-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
  • [Journal Article] Culture systems for hepatitis E virus2013

    • Author(s)
      Okamoto H.
    • Journal Title

      J Gastroenterol

      Volume: 48(2) Pages: 147-58

    • NAID

      10031156300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Culture systems for hepatitis E virus2013

    • Author(s)
      Okamoto H
    • Journal Title

      Journal of Gastroenterology

      Volume: 48 Issue: 2 Pages: 147-158

    • DOI

      10.1007/s00535-012-0682-0

    • NAID

      10031156300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Features of hepatitis E virus infection in humans and animals in Japan2013

    • Author(s)
      Takahashi M, Okamoto H
    • Journal Title

      Hepatol Res

      Volume: 44 Issue: 1 Pages: 43-58

    • DOI

      10.1111/hepr.12175

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013

    • Author(s)
      Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H
    • Journal Title

      Arch Virol

      Volume: 158(1) Pages: 87-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan2013

    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 6 Pages: 694-699

    • DOI

      10.1111/hepr.12155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-25860343
  • [Journal Article] 抗肝炎ウイルス薬(A型肝炎、E型肝炎)2013

    • Author(s)
      岡本宏明
    • Journal Title

      臨床と微生物

      Volume: 40 Pages: 57-63

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012

    • Author(s)
      Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
    • Journal Title

      Arch Virol

      Volume: 157(2) Pages: 235-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains : demonstration of HEV infectivity of porcine liver sold as food2012

    • Author(s)
      Takahashi H
    • Journal Title

      Archives of Virology

      Volume: 157 Issue: 2 Pages: 235-246

    • DOI

      10.1007/s00705-011-1153-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
  • [Journal Article] E型肝炎ウイルス培養系2012

    • Author(s)
      岡本宏明
    • Journal Title

      化学療法の領域

      Volume: 28 Pages: 114-123

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012

    • Author(s)
      Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S.
    • Journal Title

      Liver Int

      Volume: 32(4) Pages: 675-88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012

    • Author(s)
      D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
    • Journal Title

      Virus Res

      Volume: 170(1-2) Pages: 126-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎ウイルス感染の現状と対策2012

    • Author(s)
      岡本宏明
    • Journal Title

      血液事業

      Volume: 35 Pages: 228-229

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012

    • Author(s)
      Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
    • Journal Title

      Infect Genet Evol

      Volume: 12(7) Pages: 1524-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012

    • Author(s)
      Jirintai S
    • Journal Title

      Virus Research

      Volume: 170 Issue: 1-2 Pages: 126-137

    • DOI

      10.1016/j.virusres.2012.09.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
  • [Journal Article] Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody2012

    • Author(s)
      Takikawa Y, Miyamoto Y, Onodera M, Kuroda H, Kasai K, Miyasaka A, Takahashi M, Okamoto H, Suzuki K
    • Journal Title

      Hepatol Res

      Volume: 42(11) Pages: 1146-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎の現状と今後の戦略2012

    • Author(s)
      岡本宏明
    • Journal Title

      日本医事新報

      Volume: 4621 Pages: 71-77

    • NAID

      40019481043

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions2011

    • Author(s)
      Nagashima S
    • Journal Title

      Journal of General Virology

      Volume: 92 Issue: 12 Pages: 2838-2848

    • DOI

      10.1099/vir.0.035378-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
  • [Journal Article] E型肝炎の現況2011

    • Author(s)
      岡本宏明
    • Journal Title

      綜合臨牀

      Volume: 60 Pages: 95-101

    • NAID

      10018198977

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes2011

    • Author(s)
      Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H.
    • Journal Title

      Arch Virol

      Volume: 156(8) Pages: 1345-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Hepatitis E virus cell culture models2011

    • Author(s)
      Okamoto H
    • Journal Title

      Virus Res

      Volume: 161(1) Pages: 65-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype2011

    • Author(s)
      Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
    • Journal Title

      J Gen Virol

      Volume: 92(Pt 4) Pages: 902-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎ウイルスのウイルス学的特徴2011

    • Author(s)
      岡本宏明
    • Journal Title

      日本臨床

      Volume: 69 Pages: 579-587

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood.2011

    • Author(s)
      Okamoto H
    • Journal Title

      Reviews in Medical Virology

      Volume: 21 Pages: 18-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
    • Journal Title

      J Gen Virol

      Volume: 92(Pt 12) Pages: 2838-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Hepatitis E virus cell culture models2011

    • Author(s)
      Okamoto H
    • Journal Title

      Virus Research

      Volume: 161 Pages: 65-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood2011

    • Author(s)
      Okamoto H
    • Journal Title

      Rev Med Virol

      Volume: 21(1) Pages: 18-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
    • Journal Title

      J Gen Virol

      Volume: 92(Pt 2) Pages: 269-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] A nationwide survey of hepatitis E virus infection in the general population of Japan2010

    • Author(s)
      Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H.
    • Journal Title

      J Med Virol

      Volume: 82(2) Pages: 271-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎をめぐって-診断法と感染培養系の確立と基礎・臨床への応用-2010

    • Author(s)
      岡本宏明
    • Journal Title

      Minophagen Medical Review

      Volume: 55 Pages: 207-218

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010

    • Author(s)
      Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
    • Journal Title

      J Clin Microbiol

      Volume: 48(4) Pages: 1112-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎ウイルス感染2010

    • Author(s)
      岡本宏明
    • Journal Title

      治療学

      Volume: 44 Pages: 974-977

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] E型肝炎ウイルスの感染培養系2010

    • Author(s)
      岡本宏明
    • Journal Title

      ウイルス

      Volume: 60 Pages: 93-104

    • NAID

      10027049135

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia2010

    • Author(s)
      Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H
    • Journal Title

      China. Arch Virol

      Volume: 155(8) Pages: 1217-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Journal Article] ORF3 protein of hepatitis E virus is essential for virion release from infected cells.2009

    • Author(s)
      Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    • Journal Title

      J Gen Virol doi:10.1099/Vir.0.010561-0(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.2009

    • Author(s)
      Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T
    • Journal Title

      J Gastroenterol 44

      Pages: 329-337

    • NAID

      10025174367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Development and characterization of a genotype 4 hepatitis E virus cell culture system using the HE-JF5/15F strain recovered from a fulminant hepatitis patient.2009

    • Author(s)
      Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H
    • Journal Title

      J Clin Microbiol 47

      Pages: 1906-1910

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.2009

    • Author(s)
      Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    • Journal Title

      J Gen Virol 90(2)

      Pages: 457-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system.2008

    • Author(s)
      Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H
    • Journal Title

      Arch Virol 153

      Pages: 657-666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.2008

    • Author(s)
      Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
    • Journal Title

      Arch Virol 153

      Pages: 1703-1713

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.2008

    • Author(s)
      Lorenzo FR, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H
    • Journal Title

      Virus Res 137

      Pages: 86-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Development and evaluation of an efficient cell-culture system for Hepatitis E virus.2007

    • Author(s)
      Tanaka T, Takahashi M, Kusano E, Okamoto H.
    • Journal Title

      J Gen Virol 88

      Pages: 903-911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.2007

    • Author(s)
      Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
    • Journal Title

      J Clin Microbiol 45(11)

      Pages: 3671-3679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia.2007

    • Author(s)
      Lorenzo FR, Tsatsralt-Od B, Ganbat S, Takahashi M, Okamoto H
    • Journal Title

      J Med Virol 79

      Pages: 1128-1137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia.2007

    • Author(s)
      Wibawa IDN, Suryadarma IGA, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H
    • Journal Title

      J Med Virol 79

      Pages: 1138-1146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Genetic variability and evolution of hepatitis E virus.2007

    • Author(s)
      Okamoto H.
    • Journal Title

      Virus Res 127(2)

      Pages: 216-228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan.2007

    • Author(s)
      Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, Takahashi M, Okamoto H
    • Journal Title

      J Med Virol 79

      Pages: 734-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006.2007

    • Author(s)
      Fukuda S, Ishikawa M, Ochiai N, Suzuki Y, Sunaga J, Shinohara N, Nozawa K, Tsuda F, Takahashi M, Okamoto H
    • Journal Title

      Arch Virol 152

      Pages: 1623-1635

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] Genetic variability and evolution of hepatitis E virus2007

    • Author(s)
      Okamoto H
    • Journal Title

      Virus Research 127

      Pages: 216-228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Journal Article] A high genomic similarity between European type hepatitis E virus subgenotype 3e Jirintai S, Jinshan, Tanggis, Manglai 18. strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan

    • Author(s)
      Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
    • Journal Title

      Jinshan, Tanggis, Manglai

    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013

    • Author(s)
      長嶋 茂雄、高橋 雅春、吉林台、小林 富成、西澤 勉、岡本 宏明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-25860343
  • [Presentation] 輸血によるウイルス感染の更なる減少を目指して2012

    • Author(s)
      岡本宏明
    • Organizer
      第36回日本血液事業学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] 経口肝炎ウイルス:最近の知見2012

    • Author(s)
      岡本宏明
    • Organizer
      第60回日本輸血細胞治療学会総会
    • Place of Presentation
      ホテルハマツ(郡山市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012

    • Author(s)
      長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-14
    • Data Source
      KAKENHI-PROJECT-23790508
  • [Presentation] E型肝炎ウイルスについての最近の知見2012

    • Author(s)
      岡本宏明
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] 特別講演「経口肝炎ウイルス:最近の知見」2012

    • Author(s)
      岡本宏明
    • Organizer
      第60回日本輸血細胞治療学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] シンポジウム「E 型肝炎ウイルスについての最近の知見」2012

    • Author(s)
      岡本宏明
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2012-11-13
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] Culture systems for hepatitis E virus2012

    • Author(s)
      Okamoto, H.
    • Organizer
      The 3rd International Forum of the 98th General Meeting of the Japanese Society of Gastroenterology
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-04-21
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
    • Organizer
      15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-13
    • Data Source
      KAKENHI-PROJECT-23790508
  • [Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
    • Organizer
      15th International Congress of Virology (第59回日本ウイルス学会学術集会)
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23790508
  • [Presentation] E型肝炎ウイルス感染の現状と対策2011

    • Author(s)
      岡本宏明
    • Organizer
      第35回日本血液事業学会総会
    • Place of Presentation
      浦和市
    • Year and Date
      2011-10-23
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011

    • Author(s)
      Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] 肝炎ウイルスと肝炎重症化(劇症化)2010

    • Author(s)
      岡本宏明
    • Organizer
      第36回日本急性肝不全研究会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-26
    • Data Source
      KAKENHI-PROJECT-22390090
  • [Presentation] Viral genotyping/sequencing の臨床的意義Genotype 4 のE 型肝炎ウイルスの全長塩基配列の解析による劇症化に関連する塩基の同定2008

    • Author(s)
      井上淳, 上野義之, 岡本宏明
    • Organizer
      第12 回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Presentation] 肝炎ウイルス研究のカッティングエッジ 基礎から臨床への贈り物 E 型肝炎ウイルス研究の進歩2008

    • Author(s)
      岡本宏明
    • Organizer
      第12 回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Presentation] 札幌市内3 医療機関に於ける最近10 年間の急性E 型肝炎の変遷2008

    • Author(s)
      水尾仁志, 姜貞憲, 狩野吉康, 本城信吾, 松居剛志, 荒川智宏, 岡本宏明, 三代俊治
    • Organizer
      第44 回日本肝臓学会総会
    • Place of Presentation
      松山
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Presentation] 当院で経験した急性E 型肝炎の2 症例2007

    • Author(s)
      岡野 宏,西村 晃,村田一素,岡本宏明
    • Organizer
      第37 回日本肝臓学会西部会
    • Place of Presentation
      長崎
    • Year and Date
      2007-12-07
    • Data Source
      KAKENHI-PROJECT-19390134
  • [Presentation] E型肝炎ウイルスの細胞侵入機構の解析

    • Author(s)
      長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜 (パシフィコ横浜)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25860343
  • 1.  TAKAHASHI Masaharu (70326841)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 41 results
  • 2.  NISHIZAWA Tsutomu (30306112)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 11 results
  • 3.  NAGASHIMA Shigeo (60433116)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 24 results
  • 4.  KOBAYASHI Tominari (00634164)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 5.  TANAKA Toshinori (30146154)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 6.  MAYUMI Makoto (00049016)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YASUDA Jiro (10282518)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  YASHIRO Takashi (80119859)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  KOUKI Tom (70350436)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  TOKITA Hajime (70254935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KOBAYASHI Eiji (00245044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MURAKAMI Takashi (00326852)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KAWAMATA Yoji (00218380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TANAKA Koichi (20115877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KANEKO Takashi (10254913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  IKEMOTO Shigenori (90048942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KAJII Eiji (40204391)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  小池 克郎 (30085625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  小原 道法 (10250218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  小俣 政男 (90125914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  吉倉 廣 (60012754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  村上 清史 (90019878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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