OKAMOTO Ryuichi 岡本隆一

Researcher Number	50451935
Other IDs	https://orcid.org/0000-0002-7047-571X
Affiliation (Current)	2024: 東京科学大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 教授 2017 – 2019: 東京医科歯科大学, 統合研究機構, 教授 2014 – 2016: 東京医科歯科大学, 再生医療研究センター, 教授 2014 – 2016: 東京医科歯科大学, 学内共同利用施設等, 教授 2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 … More 2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座准教授 2012: 東京医科歯科大学, 医歯学総合研究科, 准教授 2011: 東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 2009 – 2011: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座教員 2010: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座准教授 2009: 東京医科歯科大学, 医歯学総合研究科, 寄附講座教員 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座准教授 2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座教員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Medium-sized Section 53:Organ-based internal medicine and related fields / Medium-sized Section 52:General internal medicine and related fields / Basic Section 53010:Gastroenterology-related / Science and Engineering Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 56050:Otorhinolaryngology-related / Science and Engineering / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / オルガノイド / 粘膜再生 / Notchシグナル / 腸管上皮 / 杯細胞 / iPS細胞 / 潰瘍性大腸炎 / 腸上皮オルガノイド / 細胞移植 … More / 上皮幹細胞 / 幹細胞 / 補充療法 / 分泌蛋白 / 機能性蛋白 / 神経内分泌腫瘍 / グラフト / 体性幹細胞 / 多能性幹細胞 / 短腸症候群 / 前腸スフェロイド / スフェロイド・デザイニング / 腸 / 胚体内胚葉 / 原腸 / スフェロイド / 原腸由来臓器 / 大腸粘膜再生 / 炎症性腸疾患？ / 大腸炎 / 胚細胞 / 消化器内科学 / 腸管上皮幹細胞 / 可塑性 / 分泌型上皮細胞 / 腸上皮幹細胞 / 消化管ホルモン / 腸上皮 / 幹細胞ニッチ / ニッチ / Notch活性化 / 腸管上皮初代培養 / ライブ・イメージング / 薬物動態解析 / 薬剤排泄 / 組織再生 / 正常腸管上皮 / 天然物リガント / 活性評価 / 生体活性評価 / 天然物リガンド / 初代培養 / 腸管上皮細胞 / MUC2 / γ-セクレターゼ阻害剤 / Deltaリガンド / Olfm4 / Hes1 / Hath1 / 上皮再生 / 腸管粘膜 / パネート細胞 / 炎症性サイトカイン … More Except Principal Investigator オルガノイド / iPS細胞 / 炎症性腸疾患 / クローン病 / 肝細胞癌 / 肝線維化 / 肝硬変 / ヒトiPS細胞 / 肝星細胞 / 腸管免疫 / 潰瘍性大腸炎 / 肝細胞 / アナジー / 星細胞 / 肝細胞オルガノイド / 携帯型超音波機器 / C型肝炎 / 代謝関連脂肪性肝疾患 / クリニカルシークエンス / RAS-MAPK経路 / がんゲノム医療 / 免疫チェックポイント阻害剤 / RAS標的治療 / 薬物治療 / 頭頸部癌 / 網羅的遺伝子解析 / 膵充実性偽乳頭腫瘍 / ケモカイン / TNFα / 慢性肝疾患 / 移植 / ディスプラジア / オルガノイド移植 / 炎症性発癌 / Dysplasia / 腸上皮オルガノイド / 体外疾患モデル / 小腸病変 / 潰瘍性大腸炎関連発癌 / 内視鏡的バルーン拡張術 / 小腸狭窄 / 小腸内視鏡 / Reg3a / 創傷治癒 / IBD / シングルセル解析 / 幹細胞 / HBV / RNAーseq / NEC / NET / RNA -seq / RNA-seq / 膵オルガノイド / pan-NEN / 膵神経内分泌腫瘍 / 肝癌 / 腫瘍免疫 / 細胞間相互作用 / 肝癌微小環境 / 塑性リセット / 炎症塑性 / ヒト体外モデル / TNFAIP3/A20 / A20 / オートファジー / 腸炎 / 生命金属 / ニッケル / TNFAIP3 / 再生医療 / 自己組織化 / 腸管グラフト / 難治性腸炎 / 腸管スフェロイド / 線維化 / 胆汁うっ滞性肝障害 / 肝前駆細胞 / T細胞 / T-T presentation / 腸管上皮間細胞 / イメージング / 腸管腫瘍 / 癌免疫 / 腸管上皮間リンパ球 / CD4-CD8-T細胞 / 抗原提示細胞 / 人工知能 / HBV integration / 空間的多様性 / 癌微小環境 / 機械学習 / 分子設計 / 天然物ケミカルバイオロジー / 国際研究者交流（韓国） / 国際研究者交流（中国） / 国際研究者交流（米国） / 異分野融合 / 国際交流（スウェーデン） / 国際交流（韓国） / 国際交流（米国） / 国際交流（ドイツ） / 天然物リガンド / 天然物化学 / 標的同定 / ケミカルバイオロジー / 天然物 / NKT細胞 / 新規治療法 / 粘膜免疫 Less

患者肝およびヒトiPS細胞由来肝オルガノイドを用いた代謝異常起因性肝発癌の病態解明
- Principal Investigator
  
  村川美也子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
携帯型超音波機器を使用したクローン病小腸病変評価方法の開発
- Principal Investigator
  
  竹中健人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
薬剤放出バイオカプセルを用いた抗炎症/組織再生統合型医療の開発Principal Investigator
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
HBVゲノム挿入iPS細胞と肝癌組織検体を用いたHBV integrationによる発癌機序の解明
- Principal Investigator
  
  新田沙由梨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
クローン病小腸病変における区域依存的幹細胞特性の解析と再生医療への応用
- Principal Investigator
  
  大塚和朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
腸上皮創傷治癒におけるReg3aの機能解析
- Principal Investigator
  
  伊藤剛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
クローン病小腸狭窄病変に対する内視鏡治療後予後改善を目指した治療法の開発
- Principal Investigator
  
  日比谷秀爾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
背景粘膜から見た潰瘍性大腸炎関連大腸癌のリスク解析
- Principal Investigator
  
  清水寛路
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
ヒトiPS細胞由来肝星細胞を基軸とした肝星細胞活性化制御機構の解明
- Principal Investigator
  
  三好正人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
炎症性腸疾患病態におけるT-T presentationの役割の解明
- Principal Investigator
  
  齊藤詠子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
難治性消化管疾患に対する統合オルガノイド医療の創成Principal Investigator
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
患者由来大腸オルガノイド移植法を用いたdysplasia-PDOXモデルの開発
- Principal Investigator
  
  福田将義
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Search for novel molecules involved in mechanisms of controlling liver pathology under viral free or inactive state
- Principal Investigator
  
  中川美奈
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
オルガノイド培養系を用いた膵充実性偽乳頭腫瘍の成立・悪性化機序の解明
- Principal Investigator
  
  小林正典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
新規RASシグナル阻害剤の頭頸部癌治療応答基盤解明
- Principal Investigator
  
  加納嘉人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokyo Medical and Dental University
Development of a single-session replacement therapy by the transplantation of personalized functional protein-producing intestinal organoidsPrincipal Investigator
- Principal Investigator
  
  岡本隆一
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
病態を再現するヒト肝臓オルガノイドの創成と肝星細胞脱活性化をめざした細胞種間解析
- Principal Investigator
  
  朝比奈靖浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Model establishment for hepatocarcinogenesis using artificial intelligence
- Principal Investigator
  
  北畑富貴子 (河合富貴子 / 河合)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
CD4-CD8αβ-TCRαβ+T細胞のアナジー誘導性抗原提示能の解析
- Principal Investigator
  
  根本泰宏
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
複合イメージング系による腸管腫瘍ニッチにおけるT細胞動態の可視化
- Principal Investigator
  
  小田柿智之
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
肝星細胞におけるTNFシグナルを基軸とした肝線維化分子機構の解明
- Principal Investigator
  
  東正新 (陳正新)
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
ヒトiPS細胞由来複合型自己組織化腸管組織を用いた難治性腸炎モデルの確立
- Principal Investigator
  
  水谷知裕
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
ヒトiPS細胞由来肝細胞オルガノイドの開発と肝線維化・発癌病態モデルの創成
- Principal Investigator
  
  柿沼晴
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
the role of biometal in the intestinal environment
- Principal Investigator
  
  大島茂
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
組織学的治癒を目指したIBD病態リセット機構の解明
- Principal Investigator
  
  土屋輝一郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Tsukuba
肝癌オルガノイドを用いた肝癌微小環境中免疫学的プロファイルに関わる病態解明
- Principal Investigator
  
  村川美也子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
自己組織化に依存しない多細胞人工発癌オルガノイドモデルの開発と細胞連関解析
- Principal Investigator
  
  朝比奈靖浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Analysis of molecular characteristics and metastatic mechanism of Pancreatic neuroendocrine neoplasm.
- Principal Investigator
  
  伊藤剛
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
炎症性腸疾患における小腸難治化機構の解明
- Principal Investigator
  
  竹中健人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Development of primitive-gut-derived organ bioengineering methods based on spheroid designing.Principal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Identification and functional analysis of colonic label-retaining goblet cells for the application to regeneration of the inflamed mucosa.Principal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Analysis and therapeutic application of intestinal epithelial cell plasticity in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Establishment of enterohormone farm by using cultured human intestinal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of colitic mucosa repair therapy by the induction of regeneration-specific stem cell niche formationPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Chemical biology using natural products
- Principal Investigator
  
  UEDA Minoru
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Development of a bio-screening method using intestinal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Okamoto Ryuichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Medical and Dental University
Analysis of intestinal mucosal repair by Notch-activated stem cellsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Novel therapeutic strategy for ulcerative colitis by targeting NKT cells
- Principal Investigator
  
  NAGAHORI Masakazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Analysis of Notch-mediated regeneration of the intestinal epitheliaPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Development of mucosa-regenerating therapy through comprehensive analysis of intestine-specific Notch target genesPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ryuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

[Book] PD-3確定診断困難な多発小腸潰瘍の1例栄養-評価と治療2012
- Author(s)
  森尾純子,荒木昭博,岡田英理子,鈴木伸治,土屋輝一郎,藤井俊光,長沼誠,長堀正和,江頭徹哉,齊藤詠子,福島啓太,河合富貴子,藤木純子,櫻井幸,根本泰宏,中川美奈,岡本隆一,東正新,柿沼晴,永石宇司,中村哲也,坂本直哉,渡辺守,河内洋,江石義信
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] Microscopic Colitis(顕微鏡的腸炎)2012
- Author(s)
  岡本隆一、渡辺守
- Publisher
  Modern Physician
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 腫瘍をめぐるQ&A(Question45)Lgr5とは?2012
- Author(s)
  伊藤剛、岡本隆一、清水寛路、村野竜朗、水谷知裕、油井史郎、土屋輝一郎、中村哲也、渡辺守
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 上皮細胞再生による腸炎治療戦略2011
- Author(s)
  中村哲也、岡本隆一、渡辺守
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 炎症性腸疾患の診断と治療をめぐる新展開2011
- Author(s)
  岡本隆一、渡辺守
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-23790777
[Book] 炎症と組織再生.FunctionalFood2011
- Author(s)
  岡本隆一、渡辺守
- Publisher
  フジメディカル
- Data Source
  KAKENHI-PROJECT-23790777
[Journal Article] Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors.2023
- Author(s)
  Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R.
- Journal Title
  
  Hepatology Reserch
  
  Volume: 53 Issue: 5 Pages: 450-459
- DOI
  10.1111/hepr.13878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-22K08005, KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
[Journal Article] Apelin expression is downregulated in T cells in a murine model of chronic colitis2023
- Author(s)
  Yamada D、Kojima Yi、Hosoya A、Suzuki、Watabe T、Inoue T、Tsugawa N、Asakawa T、Yonemoto Y、Onizawa M、Nemoto Y、Oshima S、Shimonaka M、Kuba Ki、Ishida J、Fukamizu A、Penninger JM、Watanabe M、Okamoto R、Nagaishi T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 647 Pages: 72-79
- DOI
  10.1016/j.bbrc.2023.01.068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05986, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22K19551, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03426, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-20K08304
[Journal Article] Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment2023
- Author(s)
  Watanabe Satoshi、Ogasawara Nobuhiko、Kobayashi Sakurako、Kirino Sakura、Inoue Masami、Hiraguri Yui、Nagata Sayaka、Shimizu Hiromichi、Ito Go、Mizutani Tomohiro、Nemoto Yasuhiro、Tsuchiya Kiichiro、Okamoto Ryuichi、Watanabe Mamoru、Yui Shiro
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 58 Issue: 4 Pages: 379-393
- DOI
  10.1007/s00535-023-01959-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08048, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-21H02898
[Journal Article] Clinical usefulness of geriatric assessment in elderly patients with unresectable hepatocellular carcinoma receiving sorafenib or lenvatinib therapy2022
- Author(s)
  Sekiguchi Shuhei、Tsuchiya Kaoru、Yasuhiro Asahina, et al.
- Journal Title
  
  Cancer Reports
  
  Volume: in press Issue: 11
- DOI
  10.1002/cnr2.1613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
[Journal Article] Transplantation of intestinal organoids into a mouse model of colitis2022
- Author(s)
  Watanabe Satoshi、Kobayashi Sakurako、Ogasawara Nobuhiko、Okamoto Ryuichi、Nakamura Tetsuya、Watanabe Mamoru、Jensen Kim B.、Yui Shiro
- Journal Title
  
  Nature Protocols
  
  Volume: 17 Issue: 3 Pages: 649-671
- DOI
  10.1038/s41596-021-00658-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03657
[Journal Article] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.2022
- Author(s)
  Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 628 Pages: 147-154
- DOI
  10.1016/j.bbrc.2022.08.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K15968
[Journal Article] Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma.2022
- Author(s)
  Matsumoto H, Tsuchiya K, Nakanishi H, Hayakawa Y, Yasui Y, Uchihara N, Suzuki K, Tanaka Y, Miyamoto H, Ishido S, Yamada M, Keitoku T, Nobusawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Tamaki N, Takahashi Y, Kurosaki M, Asahina Y, Okamoto R, Izumi N.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 14 Issue: 14 Pages: 3551-3551
- DOI
  10.3390/cancers14143551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
[Journal Article] Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR.2022
- Author(s)
  Nakagawa M, Asahina Y, Kakinuma S, Okamoto R.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 58 Issue: 4 Pages: 299-310
- DOI
  10.1007/s00535-022-01940-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-22K08005, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-23K24315
[Journal Article] Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids2022
- Author(s)
  Takahashi Junichi、Mizutani Tomohiro、Sugihara Hady Yuki、Nagata Sayaka、Kato Shu、Hiraguri Yui、Takeoka Sayaka、Tsuchiya Mao、Kuno Reiko、Kakinuma Sei、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 11 Pages: 100337-100337
- DOI
  10.1016/j.crmeth.2022.100337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02896
[Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022
- Author(s)
  Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
- Journal Title
  
  Lancet Gastroenterol Hepatol
  
  Volume: 7 Issue: 3 Pages: 230-237
- DOI
  10.1016/s2468-1253(21)00372-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K15991, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
[Journal Article] Development and Application of Regenerative Medicine in Inflammatory Bowel Disease2022
- Author(s)
  Okamoto Ryuichi、Mizutani Tomohiro、Shimizu Hiromichi
- Journal Title
  
  Digestion
  
  Volume: 104 Issue: 1 Pages: 24-29
- DOI
  10.1159/000527423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00465, KAKENHI-PROJECT-21H02895
[Journal Article] Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation2022
- Author(s)
  Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 42 Issue: 1 Pages: 49-49
- DOI
  10.1186/s41232-022-00237-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06544, KAKENHI-PROJECT-22K06923, KAKENHI-PROJECT-22K08048, KAKENHI-PROJECT-22K09680, KAKENHI-PROJECT-21KK0146, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03381, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02898
[Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022
- Author(s)
  Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 592 Pages: 74-80
- DOI
  10.1016/j.bbrc.2021.12.111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20H00467, KAKENHI-PLANNED-17H06414, KAKENHI-PUBLICLY-20H05314, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304, KAKENHI-PUBLICLY-21H05743, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20K07353, KAKENHI-PROJECT-21K15968, KAKENHI-WRAPUP-22H04899
[Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021
- Author(s)
  Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
- Journal Title
  
  Journal of Gastroenterolog.
  
  Volume: 56 Issue: 8 Pages: 732-745
- DOI
  10.1007/s00535-021-01792-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-18KK0438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08860, KAKENHI-PROJECT-21K08579
[Journal Article] Importance of Telomere Shortening in the Pathogenesis of Ulcerative Colitis: A New Treatment From the Aspect of Telomeres in Intestinal Epithelial Cells2021
- Author(s)
  Watanabe Sho、Hibiya Shuji、Katsukura Nobuhiro、Kitagawa Sayuki、Sato Ayako、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 16 Issue: 1 Pages: 109-121
- DOI
  10.1093/ecco-jcc/jjab115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-21K15918
[Journal Article] Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum2021
- Author(s)
  Nagaishi Takashi、Watabe Taro、Kotake Kunihiko、Kumazawa Toshihiko、Aida Tomomi、et al.
- Journal Title
  
  Gut
  
  Volume: 71 Issue: 3 Pages: 487-496
- DOI
  10.1136/gutjnl-2020-322873
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07620, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H00978, KAKENHI-PROJECT-19H01025, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K18255
[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021
- Author(s)
  Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 542 Pages: 40-47
- DOI
  10.1016/j.bbrc.2021.01.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021
- Author(s)
  Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 25 Pages: 100906-100906
- DOI
  10.1016/j.bbrep.2020.100906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021
- Author(s)
  Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
- Journal Title
  
  Cell Mol Gastroenterol Hepatol.
  
  Volume: 11 Issue: 5 Pages: 1483-1503
- DOI
  10.1016/j.jcmgh.2021.01.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02790, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K07964, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-19K08461, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898
[Journal Article] Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic Images2021
- Author(s)
  Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Shiori Oshima, Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  Gastroenterology
  
  Volume: 160 Issue: 6 Pages: 2175-2177
- DOI
  10.1053/j.gastro.2021.01.210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K07977
[Journal Article] Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis2021
- Author(s)
  Watanabe Sho、Nishimura Ryu、Shirasaki Tomoaki、Katsukura Nobuhiro、Hibiya Shuji、Kirimura Susumu、Negi Mariko、Okamoto Ryuichi、Matsumoto Yuka、Nakamura Tetsuya、Watanabe Mamoru、Tsuchiya Kiichiro
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: inpress Issue: 9 Pages: 1558-1572
- DOI
  10.1093/ecco-jcc/jjab032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22867, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19K17425, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-21H02898
[Journal Article] Early experience of atezolizumab plus bevacizumab therapy in Japanese patients with unresectable hepatocellular carcinoma in real-world practice2021
- Author(s)
  Hayakawa Yuka、Tsuchiya Kaoru、Yasuhiro Asahina, et al.
- Journal Title
  
  Investigational New Drugs
  
  Volume: 40 Issue: 2 Pages: 392-402
- DOI
  10.1007/s10637-021-01185-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K19476
[Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production.2021
- Author(s)
  Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
- Journal Title
  
  Biochemistry and Biophysics Reports.
  
  Volume: 27 Pages: 101065-101065
- DOI
  10.1016/j.bbrep.2021.101065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-21H02897, KAKENHI-PROJECT-21H02898, KAKENHI-PROJECT-20K08304
[Journal Article] Tenofovir alafenamide for prevention and treatment of hepatitis B virus reactivation and de novo hepatitis.2021
- Author(s)
  Inada K, Kaneko S, Kurosaki M, Yamashita K, Kirino S, Osawa L, Hayakawa Y, Sekiguchi S, Higuchi M, Takaura K, Maeyashiki C, Tamaki N, Yasui Y, Itakura J, Takahashi Y, Tsuchiya K, Nakanishi H, Okamoto R, Izumi N.
- Journal Title
  
  JGH Open
  
  Volume: 19 Issue: 9 Pages: 1085-1091
- DOI
  10.1002/jgh3.12636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07977
[Journal Article] Influence of chronic inflammation on the malignant phenotypes and the plasticity of colorectal cancer cells.2021
- Author(s)
  Watanabe S, Hibiya S, Katsukura N, Kitagawa S, Sato A, Okamoto R, Watanabe M, Tsuchiya K
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: - Pages: 101031-101031
- DOI
  10.1016/j.bbrep.2021.101031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-21H02898
[Journal Article] Organoid-based regenerative medicine for inflammatory bowel diasease.2020
- Author(s)
  Okamoto R, Shimizu H, Suzuki K, Kawamoto A, Takahashi J, Kawai M, Nagata S, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Watanabe M
- Journal Title
  
  Regen Ther.
  
  Volume: 13 Pages: 1-6
- DOI
  10.1016/j.reth.2019.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-19K23990
[Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage2020
- Author(s)
  Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 4 Pages: 971-977
- DOI
  10.1016/j.bbrc.2019.11.158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-17H04024
[Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo2020
- Author(s)
  Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 2 Pages: 328-335
- DOI
  10.1016/j.bbrc.2019.12.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08388, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17H04024
[Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019
- Author(s)
  Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
- Journal Title
  
  Mol Cancer Res.
  
  Volume: in press Issue: 7 Pages: 1459-1467
- DOI
  10.1158/1541-7786.mcr-18-1195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-19K17425, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-17H04024
[Journal Article] Stem cell-based therapy for inflammatory bowel disease.2019
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto
- Journal Title
  
  Intest Res
  
  Volume: 17 Issue: 3 Pages: 311-316
- DOI
  10.5217/ir.2019.00043
- Open Access
- Data Source
  KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-19K17484
[Journal Article] Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium2018
- Author(s)
  Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 10 Issue: 1 Pages: 27-42
- DOI
  10.1016/j.stemcr.2017.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513
[Journal Article] Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties2018
- Author(s)
  Suzuki Kohei、Murano Tatsuro、Shimizu Hiromichi、Ito Go、Nakata Toru、Fujii Satoru、Ishibashi Fumiaki、Kawamoto Ami、Anzai Sho、Kuno Reiko、Kuwabara Konomi、Takahashi Junichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 9 Pages: 1035-1047
- DOI
  10.1007/s00535-018-1437-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16K09302, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients2018
- Author(s)
  Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 13 Issue: 4 Pages: 495-509
- DOI
  10.1093/ecco-jcc/jjy180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K15743, KAKENHI-PROJECT-18K15774, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-18H02867, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674, KAKENHI-PROJECT-18H02791
[Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1.2017
- Author(s)
  Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
- Journal Title
  
  Autophagy.
  
  Volume: 22 Issue: 2 Pages: 1-43
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  10.1080/15548627.2017.1407889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-16K15423, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-26241014
[Journal Article] Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.2017
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
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  Biochem Biophys Res Commun.
  
  Volume: 482 Issue: 4 Pages: 1296-1303
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  10.1016/j.bbrc.2016.12.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells2017
- Author(s)
  Yoneyama Tatsuro、Arai Midori A.、Akamine Ryuta、Koryudzu Kazune、Tsuchiya Anna、Sadhu Samir K.、Ahmed Firoj、Itoh Motoyuki、Okamoto Ryuichi、Ishibashi Masami
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Issue: 9 Pages: 2453-2461
- DOI
  10.1021/acs.jnatprod.7b00282
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305001, KAKENHI-PROJECT-15H04650, KAKENHI-PROJECT-16H05284, KAKENHI-PROJECT-17H03992
[Journal Article] Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.2016
- Author(s)
  Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R
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  Data Brief.
  
  Volume: 10 Pages: 551-556
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  10.1016/j.dib.2016.12.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-16H05284
[Journal Article] PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.2016
- Author(s)
  Fujii S, Okamoto R, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Watanabe M
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 36795-36795
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  10.1038/srep36795
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-16K09302
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2016
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  Hayashi R , Tsuchiya K, Okamoto R,Watanabe M,et al
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 22 Issue: 5 Pages: 1119-28
- DOI
  10.1097/mib.0000000000000707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-16K09302
[Journal Article] Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease.2016
- Author(s)
  Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  J. Gastroenterol
  
  Volume: 51 Issue: 1 Pages: 11-21
- DOI
  10.1007/s00535-015-1098-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293170
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2016
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  Hayashi R , Tsuchiya K, Okamoto R, Watanabe M.et al.
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 22 Pages: 1119-1128
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102003
[Journal Article] Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells.2016
- Author(s)
  Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 469 Issue: 4 Pages: 1062-1068
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  10.1016/j.bbrc.2015.12.105
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08988, KAKENHI-PROJECT-26460358, KAKENHI-PROJECT-26460987, KAKENHI-PROJECT-15K15285, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-15K08989, KAKENHI-PROJECT-16H05285
[Journal Article] Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases.2015
- Author(s)
  Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  Digestion
  
  Volume: 92 Issue: 2 Pages: 73-77
- DOI
  10.1159/000438663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-25293170
[Journal Article] Reduced human α-defensin 6 in non-inflamed jejunal tissue of Crohn’s disease patients2015
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  Hayashi R , Tsuchiya K, Okamoto R, Watanabe M.et al.
- Journal Title
  
  Inflammatory Bowel Diseases
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293170
[Journal Article] Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.2015
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  Keita Fukushima, Kiichiro Tsuchiya,Okamoto Ryuichi, Mamoru Watanabe,et al
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 8 Pages: 1000-7
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  10.1111/cas.12703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15287, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-15H04808, KAKENHI-PROJECT-25293170
[Journal Article] TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy.2015
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  Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Averil Ma, Watanabe M
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  Autophagy
  
  Volume: 11 Issue: 7 Pages: 1052-1062
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  10.1080/15548627.2015.1055439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-15K15286, KAKENHI-PROJECT-15K15288, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-25293170
[Journal Article] Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.2014
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  Shimizu H, Okamoto R, Ito G, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M.
- Journal Title
  
  PeerJ
  
  Volume: 2 Pages: e370-e370
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  10.7717/peerj.370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25860524
[Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.2014
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  Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M.
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  PLoS One
  
  Volume: 9 Issue: 2 Pages: e88369-e88369
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  10.1371/journal.pone.0088369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25670708, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-26460963
[Journal Article] Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt.2014
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  N. Horita, K. Tsuchiya, R. Hayashi, K. Fukushima, S. Hibiya, M. Fukuda, Y. Kano, T. Mizutani, Y. Nemoto, S. Yui, R. Okamoto, T. Nakamura, M. Watanabe
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 454 Issue: 4 Pages: 493-499
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  10.1016/j.bbrc.2014.10.091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524, KAKENHI-PROJECT-26221307
[Journal Article] RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.2014
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  Y. Matsuzawa , S. Oshima, Y. Nibe, M.Kobayashi, C. Maeyashiki, Y. Nemoto, T. Nagaishi, R. Okamoto R, K. Tsuchiya, T. Nakamura, M. Watanabe.
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  Biochem Biophys Res Commun
  
  Volume: 456(1) Issue: 1 Pages: 298-304
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  10.1016/j.bbrc.2014.11.075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460946, KAKENHI-PROJECT-26460963, KAKENHI-PROJECT-26221307
[Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.2013
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  Kano Y
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  Biochem. Biophys. Res. Commun.
  
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  10.1016/j.bbrc.2013.01.034
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- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23390062, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790357, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells.2013
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  Gut.
  
  Volume: 62 Issue: 8 Pages: 1142-1152
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  10.1136/gutjnl-2012-302029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590933, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota.2013
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  J Immunol.
  
  Volume: 190 Issue: 12 Pages: 6616-6625
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  10.4049/jimmunol.1202930
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  KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24659375, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25670367
[Journal Article] IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice.2013
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  Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M.
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  Immunol Lett.
  
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  KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170
[Journal Article] Wnt5a Signaling Mediates Biliary Differentiation of Fetal Hepatic Stem/Progenitor Cells2013
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  Hepatology
  
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  10.1002/hep.26293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831, KAKENHI-ORGANIZER-23112001, KAKENHI-PLANNED-23112004, KAKENHI-PROJECT-23689040, KAKENHI-PROJECT-23790777, KAKENHI-PUBLICLY-24112505, KAKENHI-PUBLICLY-24112519, KAKENHI-PROJECT-24390304, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-25250018, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-25460271, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522, KAKENHI-PLANNED-23102003, KAKENHI-PLANNED-23106004
[Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.2013
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  KAKENHI-PROJECT-22229005, KAKENHI-PLANNED-23102003, KAKENHI-PROJECT-24590935, KAKENHI-PROJECT-24590936, KAKENHI-PUBLICLY-25114703, KAKENHI-PUBLICLY-25130704, KAKENHI-PROJECT-25293170, KAKENHI-PROJECT-25460945, KAKENHI-PROJECT-25461031, KAKENHI-PROJECT-25670367, KAKENHI-PROJECT-25860524
[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012
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  Yui S, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
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  Nat Med
  
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- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel'sdiverticulum: a case report2012
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  Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
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  J Med Case Rep
  
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  10.1186/1752-1947-6-328
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- Data Source
  KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23790776, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590935, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506
[Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012
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  Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
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  Nature Medicine
  
  Volume: 18 Issue: 4 Pages: 618-623
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  10.1038/nm.2695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-23890204, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PROJECT-24689036, KAKENHI-PROJECT-24790684, KAKENHI-PUBLICLY-24112508, KAKENHI-PUBLICLY-24112523
[Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012
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  Mizutani T, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 238-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012
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  Mizutani T, Nakamura T, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Issue: 2 Pages: 238-243
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  10.1016/j.bbrc.2012.01.155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590803, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PLANNED-23102003, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24390186, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PUBLICLY-24112508
[Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012
- Author(s)
  Yamaji O, Totsuka T
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 6 Pages: 2524-2536
- DOI
  10.4049/jimmunol.1100371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-21590806, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PROJECT-22590696, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23390112, KAKENHI-PROJECT-23590934, KAKENHI-PROJECT-23659223, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24590936, KAKENHI-PROJECT-24590937, KAKENHI-PLANNED-23102003
[Journal Article] The development of colitogenic CD4+T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012
- Author(s)
  Nagaishi T, Yamaji O, Okamoto R, Watanabe M, et al
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 2524-2536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Tsuchiya K, Okamoto R, Watanabe M.(他4名、3番目)
- Journal Title
  
  Inflamm Bowel Dis.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.2011
- Author(s)
  Zheng X, Okamoto R., et al
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Upregulated IL-7 receptor (alpha) expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.2011
- Author(s)
  Shinohara T, Okamoto R, Nakamura T, Watanabe M (他6名、5番目)
- Journal Title
  
  J Immunol. 186
  
  Pages: 2623-2632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42011
- Author(s)
  Iwasaki M, Tsuchiya K, Suzuki S, Watanabe M, et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Issue: 2 Pages: 191-202
- DOI
  10.1007/s00535-010-0346-x
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777
[Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation2011
- Author(s)
  Nemoto Y, Watanabe M
- Journal Title
  
  Gastroenterology
  
  Volume: 141 Issue: 6 Pages: 2130-2139
- DOI
  10.1053/j.gastro.2011.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590804, KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23659394, KAKENHI-PROJECT-23790777
[Journal Article] Suppression of Hath1 gene expression directly regulated by Heslvia Notch signaling is associated with goblet cell depletion in ulcerative colitis2011
- Author(s)
  Zheng X, Nakamura T, et al
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 17 Issue: 11 Pages: 2251-2260
- DOI
  10.1002/ibd.21611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590805, KAKENHI-PUBLICLY-22117508, KAKENHI-PROJECT-22229005, KAKENHI-PROJECT-22590694, KAKENHI-PROJECT-22590695, KAKENHI-PUBLICLY-23130506, KAKENHI-PROJECT-23790777, KAKENHI-PROJECT-24659359
[Journal Article] IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.2010
- Author(s)
  Kameyama K, Okamoto R, Nakamura T, Watanabe M (他7名、5番目)
- Journal Title
  
  Eur JImmunol. 40
  
  Pages: 423-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells2010
- Author(s)
  Akiyama J, Okamoto R, et al
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Longitudinal cell formation in theentire human small intestine is correlated with the localization of Hath1 and Klf4.2010
- Author(s)
  Iwasaki M, Okamoto R, Nakamura T, Watanabe M (他11名、3番目)
- Journal Title
  
  J Gastroenterol. 46
  
  Pages: 191-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Delta-like1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.2010
- Author(s)
  Akiyama J, Okamoto R, Nakamura T, Watanabe M (他4名、2番目)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 393
  
  Pages: 662-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf42010
- Author(s)
  Iwasaki M, Okamoto R., et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 191-202
- NAID
  10029027237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.2010
- Author(s)
  Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, TaWatkebayashi T, Naganuma M, Watanaabe M
- Journal Title
  
  J G astroenterol
  
  Volume: 45 Pages: 1008-1013
- NAID
  10027699223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia2009
- Author(s)
  Okamoto R, Tsuchiya K, et.al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis.2009
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M.(他8名、7番目)
- Journal Title
  
  J. Immunol. 183(8)
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M, Okamoto R, et al
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells.2009
- Author(s)
  Murayama M, Okamoto R, Nakamura T, Watanabe M(他4名、2番目)
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.2009
- Author(s)
  Onizawa M, Okamoto R, Nakamura T, Watanabe M(他12名、9番目)
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells2009
- Author(s)
  Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T, Watanabe M
- Journal Title
  
  J Gastroenterol 44(3)
  
  Pages: 173-182
- NAID
  10025173646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009
- Author(s)
  Okamoto R, Nakamura T, Watanabe M (他4名、1番目)
- Journal Title
  
  Am.J.Physiol.Gastrointest.Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis2009
- Author(s)
  Nemoto Y, Okamoto R, et al
- Journal Title
  
  J Immunol 183
  
  Pages: 5059-5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Signaling pathway via TNF/NF B in intestinal epithelial cell smay be directly involved in colitis associatedcarcinogenesis2009
- Author(s)
  Nagaishi T, Onizawa M Okamoto R, Watanabe M, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590806
[Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis.2009
- Author(s)
  Tomita T, Okamoto R, Watanabe M.(他7名)
- Journal Title
  
  Eur J Immunol. 39
  
  Pages: 2737-2747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] RANK-RANKL signaling pathway is critically in volvedin the function of CD4+CD25+ regulatory T cells in chronic colitis.2009
- Author(s)
  Totsuka T, Okamoto R, Nakamura T, Watanabe M(他8名、5番目)
- Journal Title
  
  J. Immunol. 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790651
[Journal Article] Requirement of Notch activation during regeneration of the intestinal epithelia.2009
- Author(s)
  Okamoto R, Tsuchiya K, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M
- Journal Title
  
  Biochem Biophys Res Commun 368(4)
  
  Pages: 923-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Colitogenic CD4(+)effector-memory T cells activelyrecirculate in chronic colitic mice2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, FujiiT, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Negative feedback regulation of colitogenic CD4(+)T cells by increased granulopoiesis2008
- Author(s)
  Nemoto Y, Kanai T, Tohda S, TotsukaT, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M
- Journal Title
  
  Inflamm Bowel Dis 14(11)
  
  Pages: 1491-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] MyD88-dependent pathway in T cellsdirectly modulates the expansionof colitogenic CD4+ T cells inchronic colitis2008
- Author(s)
  Tomita T, Kanai T, Fujii T, NemotoY, Okamoto R, Tsuchiya K, TotsukaT, Sakamoto N, Akira S, Watanabe M
- Journal Title
  
  J Immunol 180(8)
  
  Pages: 5291-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis2008
- Author(s)
  Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, TotsukaT, Okamoto R, Tsuchiya K, SakamotoN, Watanabe M
- Journal Title
  
  J Immunol 180(1)
  
  Pages: 383-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.2008
- Author(s)
  Yoshioka A, Okamoto R, et al.
- Journal Title
  
  Cytokine. 44
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 alpha during intestinal epithelial cell differentiation.2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, et al.
- Journal Title
  
  RNA. 14
  
  Pages: 1433-1442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation.2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, et. al.
- Journal Title
  
  RNA (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Immunosenescent colitogenic CD4(+)T cells convert to regulatory cells and suppress colitis2008
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, TomitaT, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M
- Journal Title
  
  Eur J Immunol 38(5)
  
  Pages: 1275-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Proteasomal degradation of Atohl by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.2008
- Author(s)
  Aragaki M, Tsuchiya K, Okamoto R, et. al.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 923-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.2008
- Author(s)
  Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, et. al.
- Journal Title
  
  Journal of Immunology 180
  
  Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells2008
- Author(s)
  Yoshioka A, Okamoto R, Oshima S, Akiyama J, Tsuchiya K, Nakamura T, Kanai T, Watanabe M
- Journal Title
  
  Cytokine 44(1)
  
  Pages: 57-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation2008
- Author(s)
  Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, Kanai T, Watanabe M
- Journal Title
  
  RNA 14(7)
  
  Pages: 1433-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, Okamoto R, et. al.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 176-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Bone Marrow Retaining Colitogenic CD4(+) T Cells May Be a Pathogenic Reservoir for Chronic Colitis2007
- Author(s)
  Nemoto Y, Kanai T, Makita S, OkamotoR, Totsuka T, Takeda K, Watanabe M
- Journal Title
  
  Gastroenterology 132(1)
  
  Pages: 176-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Reciprocal targeting of Hath1 and beta-cateninby Wnt-glycogen synthase kinase 3 beta in human colon cancer2007
- Author(s)
  Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M
- Journal Title
  
  Gastroenterology 132(1)
  
  Pages: 208-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] IL-7 Is essential for the development and the persistence of chronic colitis2007
- Author(s)
  Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4737-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Reciprocal targeting of Hathl and β-catenin by Wnt-glycogen synthase kinase 3 β in human colon cancer.2007
- Author(s)
  Tsuchiya K, Nakamura T, Okamoto R, et. al.
- Journal Title
  
  Gastroenterology 132
  
  Pages: 208-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Journal Article] Intestinal lamina propria retaining CD4+CD25+regulatory T cells is a suppressive site of intestinal inflammation2007
- Author(s)
  Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M
- Journal Title
  
  J Immunol 178(8)
  
  Pages: 4937-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor.2023
- Author(s)
  Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto
- Organizer
  2023 RIKEN BDR-CuSTOM Joint Organoid Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02895
[Presentation] Bench-to-bedside research: Patient-derived organoid transplantation for treatment of intractable ulcerative colitis2023
- Author(s)
  Ryuichi Okamoto
- Organizer
  SIDDS (Seoul, Korea)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00465
[Presentation] オルガノイドによる腸組織再生医療のアプローチ2023
- Author(s)
  水谷知裕, 髙橋純一, 杉原ハディ優樹, 加藤周, 永田紗矢香, 渡辺守, 岡本隆一
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02895
[Presentation] 炎症性腸疾患に対する再生医療2023
- Author(s)
  岡本隆一,水谷知裕, 清水寛路, 永田紗矢香, 平栗優衣, 杉原ハディ優樹, 加藤周, 髙橋純一, 福田将義, 大塚和明
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02895
[Presentation] 炎症性腸疾患に対する再生医療2023
- Author(s)
  岡本　隆一
- Organizer
  第22回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-22H00465
[Presentation] ヒトiPS細胞由来肝細胞オルガノイドの樹立と疾患モデルへの応用2022
- Author(s)
  志水太郎、三好正人、柿沼晴、土屋淳、持田知洋、渡壁慶也、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07939
[Presentation] ヒトiPS細胞を利用したMLL4領域へのB型肝炎ウイルスゲノム挿入による肝発癌メカニズムの解析2022
- Author(s)
  土屋淳、三好正人、朝比奈靖浩、岡本隆一、柿沼　晴
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21H02896
[Presentation] 膵SPNの病態解明にむけた集学的解析2022
- Author(s)
  小林正典, 伊藤剛, 申貴広, 山下宏成, 工藤篤, 田邉稔, 岡本隆一
- Organizer
  第64回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-22K08029
[Presentation] ヒトiPS細胞を利用したB型肝炎ウイルス関連肝細胞癌発癌におけるMLL4の機能解析2022
- Author(s)
  土屋淳、柿沼晴、三好正人、志水太郎、渡壁慶也、持田知洋、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08005
[Presentation] ヒトiPS細胞由来肝細胞オルガノイドの樹立と疾患モデルへの応用.2022
- Author(s)
  志水太郎、三好正人、柿沼晴、土屋淳、持田知洋、渡壁慶也、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H02896
[Presentation] Analysis of molecular characteristics and metastatic mechanism of pancreatic neuroendocrine neoplasms.2022
- Author(s)
  Ryota Kuribayashi, Go Ito, Neha Mishra, Yui Hiraguri, Hiromune Katsuda, Masanori Kobayashi, Tomohiro Muto, Hironari Yamashita, Atsushi Kudo,Minoru Tanabe, Konrad Aden, Philip Rosenstiel,Mamoru Watanabe, Ryuichi Okamoto
- Organizer
  International Syscid Symposium, 2022.Kiel, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0146
[Presentation] ヒトiPS細胞由来肝細胞オルガノイド培養系の確立と形質解析2022
- Author(s)
  志水太郎、三好正人、朝比奈靖浩、岡本隆一、柿沼　晴
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21H02896
[Presentation] ヒトiPS細胞を利用したB型肝炎ウイルス関連肝細胞癌発癌におけるMLL4の機能解析2022
- Author(s)
  土屋淳、柿沼晴、三好正人、志水太郎、渡壁慶也、持田知洋、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07939
[Presentation] 脂肪性肝疾患の病態形成における腸管疾患の関与2022
- Author(s)
  渡壁慶也、金子俊、朝比奈靖浩、稲田賢人、持田知洋、志水太郎、土屋淳、三好正人、北畑富貴子、新田沙由梨、村川美也子、藤井俊光、井津井康浩、中川美奈、柿沼晴、岡本隆一
- Organizer
  第44回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-21K07939
[Presentation] ヒトiPS細胞由来肝細胞オルガノイドの樹立と疾患モデルへの応用2022
- Author(s)
  志水太郎、三好正人、柿沼晴、土屋淳、持田知洋、渡壁慶也、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07977
[Presentation] 脂肪性肝疾患の病態形成における腸管疾患の関与　クローン病での解析2022
- Author(s)
  渡壁慶也、金子俊、朝比奈靖浩、稲田賢人、持田知洋、志水太郎、土屋淳、三好正人、北畑富貴子、新田沙由梨、村川美也子、藤井俊光、井津井康浩、中川美奈、柿沼晴、岡本隆一
- Organizer
  第44回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-22K08005
[Presentation] ヒトiPS細胞由来肝細胞オルガノイドの樹立と疾患モデルへの応用2022
- Author(s)
  志水太郎、三好正人、柿沼晴、土屋淳、持田知洋、渡壁慶也、北畑富貴子、新田沙由梨、村川美也子、井津井康浩、東正新、中川美奈、朝比奈靖浩、岡本隆一
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08005
[Presentation] 膵SPNの病態解明にむけた集学的解析2022
- Author(s)
  小林正典, 伊藤剛, 申貴広, 山下宏成, 工藤篤, 田邉稔, 岡本隆一
- Organizer
  第64回　日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-21KK0146
[Presentation] ヒトiPS細胞由来肝細胞オルガノイド培養系の確立と形質解析2022
- Author(s)
  志水太郎、三好正人、朝比奈靖浩、岡本隆一、柿沼晴
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K07977
[Presentation] 炎症性腸疾患と再生医療2022
- Author(s)
  岡本　隆一
- Organizer
  第40回日本大腸検査学会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00465
[Presentation] ヒトiPS細胞培養系を利用したB型肝炎ウイルスゲノム組み込みによる発癌プロセスの解析2021
- Author(s)
  土屋淳、三好正人、紙谷聡英、志水太郎、新田沙由梨、北畑富貴子、渡壁慶也、持田知洋、村川美也子、中川美奈、東正新、朝比奈靖浩、朝比奈靖浩、岡本隆一、柿沼晴
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K07909
[Presentation] ヒト大腸organoid潰瘍性大腸炎モデルの炎症性発癌予防への応用2021
- Author(s)
  渡辺　翔、土屋輝一郎、岡本　隆一
- Organizer
  JDDW 2021
- Data Source
  KAKENHI-PROJECT-21H02898
[Presentation] ヒトiPS細胞培養系を利用したB型肝炎ウイルスゲノム組み込みによる発癌プロセスの解析2021
- Author(s)
  土屋淳、三好正人、紙谷聡英、志水太郎、新田沙由梨、北畑富貴子、渡壁慶也、持田知洋、村川美也子、中川美奈、東正新、朝比奈靖浩、朝比奈靖浩、岡本隆一、柿沼晴
- Organizer
  第28回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21H02896
[Presentation] 生命金属による腸管炎症・惹起機構の解析2021
- Author(s)
  松田浩紀、青沼映美、田村皓子、仁部洋一、渡辺守、岡本隆一、宇尾基弘、大島茂.
- Organizer
  第58回日本消化器免疫学会
- Data Source
  KAKENHI-PROJECT-21H02897
[Presentation] 肝内胆管癌の病態と網羅的がんゲノム解析の有用性．2021
- Author(s)
  加納嘉人、北畑富貴子、村川美也子、柿沼晴、東正新、中川美奈、井津井康浩、新田沙由梨、三好正人、田邉稔、三宅智、池田貞勝、岡本隆一、朝比奈靖浩．
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K19476
[Presentation] 腸管炎症惹起機構における生命金属の役割2021
- Author(s)
  大島　茂、松田浩紀、青沼映美、田村皓子、仁部洋一、渡辺守、宇尾基弘、岡本隆一
- Organizer
  第94回日本生化学学会大会
- Data Source
  KAKENHI-PROJECT-21H02897
[Presentation] Organoid-based regenerative and precision medicine for IBD2021
- Author(s)
  Okamoto R
- Organizer
  KDDW2021
- Invited
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] ヒト iPS 細胞培養系を利用した B 型肝炎ウイルスゲノム組み込みによる発癌プロセスの解析.2021
- Author(s)
  土屋淳，三好正人，紙谷聡英，志水太郎，新田沙由梨，北畑富貴子，渡壁慶也，持田知洋，村川美也子，中川美奈，東正新，朝比奈靖浩，岡本隆一，柿沼晴.
- Organizer
  第 28 回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K19476
[Presentation] 東京医科歯科大学における内視鏡を用いた基礎研究の取り組み2021
- Author(s)
  岡本隆一
- Organizer
  第101回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] 1.東京医科歯科大学における内視鏡を用いた基礎研究の取り組み2021
- Author(s)
  岡本隆一
- Organizer
  第101回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-20K21597
[Presentation] Organoid-based regenerative and precision medicine for IBD2021
- Author(s)
  Okamoto R
- Organizer
  KDDW2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597
[Presentation] 【シンポジウム13：組織再生とオルガノイド】腸上皮幹細胞オルガノイドによる粘膜再生医療2019
- Author(s)
  岡本隆一
- Organizer
  第40回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] Long-term inflammation model using human colonic organoids2019
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  AOCC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] Establishment of chronic inflammation model using human small intestinal and colonic organoids2019
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Sho Watanabe, Nobuhiro Katsukura, Tomoaki Shirasaki, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  UEG Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] 【消化器疾患と再生医療】炎症性腸疾患に対する再生医療の開発2019
- Author(s)
  岡本隆一、清水寛路、渡辺　守
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] 【Focus Session: Cutting Edge Regenerative Medicine Using Stem Cells】Intestinal Epithelial Stem Cell Organoids and IBD2019
- Author(s)
  Okamoto R, Watanabe M
- Organizer
  ISSCR2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] Functional analysis of isoflavones using patient-derived intestinal organoids2019
- Author(s)
  Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M
- Organizer
  AOCC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] Synergy of Notch signalling and TNF-alpha in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein.2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Okamoto R, Mamoru Watanabe et al.
- Organizer
  14th ECCO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] 【The 6th JSGE International Topic Conference Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）：Food-bome factors in inflammatory bowel disease2019
- Author(s)
  Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe
- Organizer
  The105th General Meeting of the Japanese Society of Gastroenterology
- Invited
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] 患者由来腸上皮オルガノイドを用いたイソフラボン類による腸上皮機能調節機構の解析2019
- Author(s)
  川井麻央、河本亜美、永田紗矢香、安斎　翔、高橋純一、久野玲子、平栗優衣、鈴木康平、清水寛路、油井史郎、岡本隆一、渡辺　守
- Organizer
  第56回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] Synergy of Notch Signaling and TNF-alpha Leads to Up-regulation of UBD in the Inflamed Intestinal Epithelia of IBD Patients2019
- Author(s)
  Kawamoto A, Nagata S, Anzai S, Okamoto R, Mamoru Watanabe et al.
- Organizer
  AOCC 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] 【Keynote lecture】腸上皮オルガノイドを用いた再生医療の開発2019
- Author(s)
  岡本隆一
- Organizer
  ヒューマン・オルガノイド技術の最前線2019
- Invited
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] 炎症性腸疾患に対する再生医療の開発2019
- Author(s)
  岡本隆一
- Organizer
  第103回IBDミニカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-19H03634
[Presentation] クローン病由来の小腸上皮オルガノイド構築による幹細胞形質の解析2018
- Author(s)
  鈴木康平, 村野竜朗, 平栗優衣, 高橋純一, 河本亜美, 石橋史明 , 安斎　翔, 久野玲子, 桒原小の実, 川井麻央, 永田紗矢香, 油井史郎, 土屋輝一郎, 中村哲也, 大塚和朗, 渡辺　守, 岡本隆一
- Organizer
  第17回再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] Jagged1 is indispensable for the maintenance of tumor stem cell niche in APC-Deficient intestinal adenomas2016
- Author(s)
  Toru Nakata, Go Ito, Hiromichi Shimizu, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] Single-cell level analysis reveals heterogeneous expression of stem-cell specific genes in human small intestinal organoids2016
- Author(s)
  Kohei Suzuki, Satoru Fujii, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Otsuka, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  ion of stem-cell specific genes in human small intestinal organoidsDDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05284
[Presentation] In vitro organoid model reveals PGE2 as a robust mediator of chloride & water secretion by human intestinal epithelial cells2016
- Author(s)
  Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe
- Organizer
  DDW2016
- Place of Presentation
  サンディエゴ（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン；米国
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima ,Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer.2015
- Author(s)
  Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture.2015
- Author(s)
  Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima ,Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine.2015
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium.2015
- Author(s)
  Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  DDW 2015
- Place of Presentation
  ワシントン（米国）
- Year and Date
  2015-05-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract.2015
- Author(s)
  Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  Pacifichem2015
- Place of Presentation
  ハワイ（米国）
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium.2015
- Author(s)
  Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15286
[Presentation] TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential.2015
- Author(s)
  Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2015
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.2015
- Author(s)
  Horita N,Tsuchiya K,Hayashi R,Fukushima K,Hibiya S,Fukuda M,Mizutani T,Okamoto R,Nakamura T and Watanabe M.
- Organizer
  AOCC2015
- Place of Presentation
  北京（中国）
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe .
- Organizer
  第8回Japan-US Collabaration Conference in Gastroenterology
- Place of Presentation
  Intercontinental TOKYO BAY (東京都港区海岸1-16-2)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells.2014
- Author(s)
  Ryuichi Okamoto, Go Ito, Hiromichi Shimizu, Satoru Fujii , Toru Nakata, Kohei Suzuki, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine2014
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine.2014
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe.
- Organizer
  The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  Seoul (Korea)
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling and TNF-α synergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.2014
- Author(s)
  Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  第8回Japan-US Collabaration Conference in Gastroenterology
- Place of Presentation
  Intercontinental TOKYO BAY (東京都港区海岸1-16-2)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells.2014
- Author(s)
  Ryuichi Okamoto, Go Ito, Hiromichi Shimizu, Satoru Fujii , Toru Nakata, Kohei Suzuki, Mamoru Watanabe.
- Organizer
  UEGW2014
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用2013
- Author(s)
  岡本隆一、村野竜朗、渡辺守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] 腸管上皮Notch-Hes1シグナルによるIL-22誘導性抗菌応答の制御2013
- Author(s)
  村野竜朗、岡本隆一、渡辺守
- Organizer
  第31回サイトプロテクション研究会
- Place of Presentation
  京都
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用2013
- Author(s)
  岡本隆一、村野竜朗、渡辺　守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Establishment of novel bio-screening methods using cultured intestinal epithelial cells2012
- Author(s)
  Okamoto R
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity.
- Place of Presentation
  Kyoto
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  ISSCR2012
- Place of Presentation
  横浜
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch-Hes1 pathway and TNF- synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine2012
- Author(s)
  Ryuichi Okamoto, Go Ito, SatoruFujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  6thKorea-Japan IBD Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novelenterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells2012
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2012
- Place of Presentation
  Amsterdam
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.2012
- Author(s)
  Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-Mediated epithelial regeneration through enhancement of STAT3-Dpendent transcription in human intestinal epithelial cells.2012
- Author(s)
  Murano T, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Real-time analysis of p-glycoprotein-mediated drugtransport across primary intestinal epithelial cellsthree-dimensionally cultured in vitro2012
- Author(s)
  Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Okamoto R, Tsuchiya K, Watanabe M
- Organizer
  DDW2012.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells.2012
- Author(s)
  Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.2012
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro.2012
- Author(s)
  Mizutani T, Nakamura T, Okamoto R, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Establishment of novel bio-screening methods using cultured intestinal epithelial cells .2012
- Author(s)
  Okamoto R
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells2012
- Author(s)
  Tatsuro Murano, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2012
- Place of Presentation
  SanDiego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa2012
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Tatsuro Murano, Go Ito, Satoru Fujii, Morio-Akiyama Junko, Kiichiro Tsuchiya, Tetsuya Nakamura, MamoruWatanabe
- Organizer
  Asian IBD Symposium Seoul 2012.
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens.2012
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch pathway and TNF-a synergistically up-regulatesOLFM4 expression in the inflamed mucosa of the human intestine2012
- Author(s)
  Ryuichi Okamoto, Morio-AkiyamaJunko, Hiromichi Shimizu, Tatsuro Murano, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  Asian IBD Symposium Seoul 2012.
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  DDW2012.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enheancement of STAT3-dependent transcription in human intestinal epithelial cells.2012
- Author(s)
  Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization2012
- Author(s)
  Kano Y, Tsuchiya K, Horita N, Zheng X, Okamoto R, Nakamura T, Watanabe M
- Organizer
  ISSCR2012.
- Place of Presentation
  Yokohama
- Year and Date
  2012-06-14
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.2012
- Author(s)
  Tsuchiya K, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells2012
- Author(s)
  Tatsuro Murano, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  6th Korea-Japan IBD Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens2012
- Author(s)
  Nemoto Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Matsumoto S, Watanabe M
- Organizer
  AGA.
- Place of Presentation
  San Diego
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells2012
- Author(s)
  Ryuichi Okamoto,Tatsuro Murano, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2012
- Place of Presentation
  SanDiego
- Year and Date
  2012-05-21
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro2012
- Author(s)
  Yui S, Nakamura T, Nemoto Y, Mizutani T, Fukuda M, Nozaki K, Yamauchi Y, Mochizuki W, Zheng X, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M
- Organizer
  第10回幹細胞シンポジウム.
- Place of Presentation
  淡路島
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling and TNF-alpha synergistically up-regulate OLFM4expression in human intestinal epithelial cells2012
- Author(s)
  Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  UEGW2012
- Place of Presentation
  Amsterdam
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro.2012
- Author(s)
  Yui S, Nakamura T, Okamoto R, Watanabe M et al
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro2011
- Author(s)
  Yui S., Okamoto R., et al
- Organizer
  GI Research Academy 2011
- Place of Presentation
  京都
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch-Hes1 pathway and TNF-α synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine2011
- Author(s)
  Okamoto R., et al
- Organizer
  DDW 2011
- Place of Presentation
  シカゴ
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch-Hes1 pathway and TNF-α synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.2011
- Author(s)
  Okamoto R. et al.
- Organizer
  DDW 2011.
- Place of Presentation
  シカゴ
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Regeneration of damaged colonic tissue by transplantation of colonic epithelial stem cells maintained and expanded in vitro2011
- Author(s)
  Yui S, Nakamura T, Nagaishi T, Okamoto R, Watanabe M, et al.
- Organizer
  アメリカ消化器病学会
- Place of Presentation
  シカゴ
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-21590806
[Presentation] Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro.2011
- Author(s)
  Yui S., Okamoto R. et al.
- Organizer
  GI Research Academy 2011.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Up-regulation of Delta1 expression is required for goblet cell differentiation in human intestinal epithelial cells2010
- Author(s)
  Akiyama J., Okamoto R., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] TNF-alpha and Notch signaling synergistically up-regulate OLFM4 expression in human intestinal epithelial cells2010
- Author(s)
  岡本隆一
- Organizer
  米国消化器病学会週間2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における粘膜修復機構の解析と上皮再生治療への応用2010
- Author(s)
  岡本隆一
- Organizer
  第6回日本消化管学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患と上皮再生2010
- Author(s)
  岡本隆一
- Organizer
  第31回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Up-regulation of Delta1 expression is required for goblet cell differentiation in human intestinal epithelial cells2010
- Author(s)
  秋山純子、岡本隆一
- Organizer
  米国消化器病学会週間2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における Notch シグナルを介した上皮再生機構2010
- Author(s)
  岡本隆一, 他
- Organizer
  第6回日本消化管学会総会学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] A well-defined culture system for colonic epithelial cells that allows efficient enrichment of LGR5+stem cells2010
- Author(s)
  Yui S, Nagaishi T, Okamoto R, Watanabe M, et al
- Organizer
  The 1st JSGE International Topic Conference-Stem cells in digestive organs
- Place of Presentation
  鎌倉
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21590806
[Presentation] TNF-α and Notch signaling synergistically up-regulate OLFM4 expression in human intestinal epithelial cells2010
- Author(s)
  Okamoto R., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  ニューオリンズ
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における上皮分化・増殖機構の解析と粘膜再生治療への応用2009
- Author(s)
  岡本隆一
- Organizer
  日本消化器病学会週間
- Place of Presentation
  京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] 炎症性腸疾患における上皮分化・増殖機構の解析と粘膜再生治療への応用2009
- Author(s)
  岡本隆一, 他
- Organizer
  JDDW 2009
- Place of Presentation
  京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notch1 activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis2009
- Author(s)
  岡本隆一
- Organizer
  米国消化器病学会週間2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notchl activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis2009
- Author(s)
  岡本隆一, et al
- Organizer
  Digestive Disease Week 2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Expression of Delta ligands is regulated by Notch-Hes1 signaling pathway in human intestinal epithelial cells2009
- Author(s)
  秋山純子、岡本隆一
- Organizer
  The Notch Meeting
- Place of Presentation
  アテネ
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Notch1 activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa ofulcerative colitis2009
- Author(s)
  岡本隆一
- Organizer
  The Notch Meeting
- Place of Presentation
  アテネ
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-21790651
[Presentation] Neutralization of tumor necrosis factor suppresses the development of colitis-associated tumor in mice2008
- Author(s)
  Onizawa M, Nagaishi T, Nemoto Y, Oshima S, Okamoto R, et.al.
- Organizer
  DDW2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Notch signaling suppresses the transcriptional activity of Hathl Gene, resulting in the undifferentiated form of human intestinal epithelial cells2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R et.al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Tsuchiya : Dysregulated differentiation of intestinal epithelia in UC2008
- Author(s)
  Okamoto R
- Organizer
  3rd Japan-Korea IBD Symposium
- Place of Presentation
  ソウル
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Notch signaling suppresses the transcriptional activity of Hath1 Gene, resulting in the undifferentiated form of human intestinal epithelial cells.2008
- Author(s)
  Tsuchiya K, Inoue K, Aragaki M, Okamoto R, et al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Dysregulated differentiation of intestinal epithelia in UC.2008
- Author(s)
  Okamoto R, Tsuchiya K
- Organizer
  3rd Japan-Korea IBD Symposium
- Place of Presentation
  ソウル
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Neutralization of tumor necrosis factor suppresses the development of colitis-associated tumor in mice.2008
- Author(s)
  Onizawa M, Nagaishi T, Nemoto Y, Oshima S, Okamoto R, et al.
- Organizer
  DDW 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Role of Notch signaling in inflammatory bowel diseases2007
- Author(s)
  Okamoto R
- Organizer
  アジア太平洋消化器病学会
- Place of Presentation
  神戸
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Activated Notch Signalling Suppresses Generation of Goblet Cells in the Human Intestinal Mucosa2007
- Author(s)
  Okamoto R
- Organizer
  全米消化器病学会
- Place of Presentation
  米国(ワシントン)
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] Activated Notch Signalling Suppresses Generation of Goblet Cellsin the Human Intestinal Mucosa2007
- Author(s)
  Okamoto R
- Organizer
  DDW 2007
- Place of Presentation
  ワシントン
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19890064
[Presentation] The acquisition of cancer stemness in colon cancer by the Atoh1 protein stabilization.
- Author(s)
  Kano Y, Okamoto R, Nakamura T, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells
- Author(s)
  Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  G. Ito, R. Okamoto, T. Murano, H. Shimizu, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS
- Author(s)
  H. Shimizu, R. Okamoto, T. Nakata, S. Fujii, G. Ito, T. Murano, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine.
- Author(s)
  Okamoto R, Murano T, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Lineage-specific expression of bestrophin genes in normal and inflamed human intestine: implications for ulcerative colitis.
- Author(s)
  Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] 炎症性腸疾患における上皮再生機構の解明と粘膜再生治療への応用
- Author(s)
  岡本隆一、村野竜朗、渡辺　守
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  R. Okamoto, T. Murano, H. Shimizu, G. Ito, S. Fujii, T. Nakata, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.
- Author(s)
  Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Hes1 promotes IL-22-Mediated epithelial regeneration through enhancement of STAT3-Dpendent transcription in human intestinal epithelial cells.
- Author(s)
  Murano T, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] LINEAGE-SPECIFIC EXPRESSION OF BESTROPHIN-2 AND BESTROPHIN-4 IS REGULATED BY NOTCH SIGNALING IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  G. Ito , R. Okamoto, T. Murano, H. Shimizu, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Colitogenic effector memory CD4+ T cells develop TH1/TH17 mediated interstitial pneumonia independent to intestinal bacterial antigens.
- Author(s)
  Nemoto Y, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Notch signaling regulates expression of Gelsolin superfamily genes, Gelsolin and Scinderin, and promotes re-assembly of actin cytoskelton in human intestinal epithelial cells.
- Author(s)
  Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] IL-22-MEDIATED ANTIMICROBIAL RESPONSE IS REGULATED BY HES1 VIA STAT3-DEPENDENT TRANSCRIPTION IN HUMAN INTESTINAL EPITHELIAL CELLS
- Author(s)
  R. Okamoto, T. Murano, H. Shimizu, G. Ito, S. Fujii, T. Nakata, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Flagellin response via TLR5 on basolateral membrane of primary intestinal epithelial cells is regulated by Notch signaling.
- Author(s)
  Tsuchiya K, Okamoto R, Nakamura T, Watanabe M et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] COMPLETE CONVERSION OF CRYPT PROGENITOR CELLS INTO ATOH1-POSITIVE CELLS BY TARGETED DELETION OF DLL1 AND DLL4 IN LGR5-POSITIVE INTESTINAL STEM CELLS
- Author(s)
  H. Shimizu, R. Okamoto, T. Nakata, S. Fujii, G. Ito, T. Murano, K. Tsuchiya, T. Nakamura, M. Watanabe
- Organizer
  UEGW 2013
- Place of Presentation
  ベルリン、ドイツ
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells
- Author(s)
  Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe
- Organizer
  The 1st Annual Meeting of Asian Organization for Crohn's and Colitis
- Place of Presentation
  東京、ラフォーレ東京
- Data Source
  KAKENHI-PROJECT-25293170
[Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa.
- Author(s)
  Shimizu H, Okamoto R, Watanabe M et al
- Organizer
  Asian IBD Symposium Seoul 2012
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-23790777
[Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells
- Author(s)
  Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
- Organizer
  DDW 2013
- Place of Presentation
  オーランド、米国
- Data Source
  KAKENHI-PLANNED-23102003
[Presentation] Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro.
- Author(s)
  Mizutani T, Nakamura T, Okamoto R, Watanabe M　et al
- Organizer
  DDW2012
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-23790777

1. 柿沼晴 (30372444)

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OKAMOTO Ryuichi 岡本 隆一

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薬剤放出バイオカプセルを用いた抗炎症/組織再生統合型医療の開発Principal Investigator

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難治性消化管疾患に対する統合オルガノイド医療の創成Principal Investigator

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OKAMOTO Ryuichi 岡本隆一