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YOSHIKI Takashi  吉木 敬

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… Alternative Names

吉木 敬  ヨシキ タカシ

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Researcher Number 60220612
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2000 – 2003: Hokkaido Univ., Grad. School of Med., Prof., 大学院・医学研究科, 教授
1993 – 2001: School of Medicine, Hokkaido University, 医学部, 教授
1994: 北大, 医学部, 教授
1990 – 1991: 北海道大学, 医学部, 教授
1988: 市立札幌病院, 病理, 医長
1986: 市立札幌病院, 医長
Review Section/Research Field
Principal Investigator
Experimental pathology / Biological Sciences
Except Principal Investigator
Experimental pathology / Human pathology / Immunology / Experimental pathology
Keywords
Principal Investigator
HTLV-I / TSP / HAM / アポトーシス / 動物モデル / トランスジェニックラット / 胸腺腫 / 自己免疫疾患 / モデル動物 / 疾患モデル … More / crm1 / トランスジェニック / HIV-1 / thymoma / animal model / 免疫制御細胞 / CACNL1A4 / 膠原病 / Apoptosis / ARF / p16 / 胸腺 / DNAアレイ / 脱髄 / ラット / autoimmune disease / transgenic / myelopathy / retrovirus / Cyclin T1 / レトロウィルス / HIV-I / 遺伝子導入 / 脊髄症 / レトロウイルス / collagen vascular diseases / transgenic rat / apoptosis / オリゴデンドロサイト / HTLV-I関連疾患 / bcl-2 / CAG triplet repeat / spinocerebellar degeneration / 遺伝子診断 / CAG反復配列 / ポリグルタミン鎖 / CACNLIA4 / CAGリピート / 脊髄小脳変性症 / COLLAGEN VASCULAR DISEASES / THYMOMA / TRANSGENIC RATS / ANIMAL MODELS / ウイルス発がん / ウィルス発がん / トランスジェクラット / Transgenic rat / Disease model / トランスジュニック / TNFα / HTLV-・ / Autoimmune Diseases / Mammary Carcinoma / Transgenic Rat / Demyelination / Disease Model / 乳癌 / HTLV-1 / 遺伝子導入ラット / 悪性化 / 上皮型胸腺腫 / CRM1 / 遺伝子改変動物 / 成人T細胞白血病 / ヒトT細胞白血病ウイルス / Nitrogen Oxide / サイトカイン … More
Except Principal Investigator
ヒト内在性レトロウイルス / 自己免疫疾患 / HTLV-1 / レトロウイルス / 血管内皮細胞 / トランスジェニックラット / 遺伝子発現 / transgenic rat / AFP / Loss of heterozygosity / 発現誘導 / CAG反復配列 / 接着分子 / サイトカイン / ATL / 遺伝子クローニング / 内在性レトロウイルス / autoimmune disease / targeted antigen / tissue-specific expression / human endogenous retrovirus / 発生と分化 / 蛋白発現 / タンパク発現 / トランシジェニックラット / 標的抗原 / 組織特異的発現 / autoimmune diseases / gene cloning / gene expression / human endogenous retroviruses / positional candidate genes for vasculitis / genomics of vasculitis / animal models for vasculitis / vasculitogenic viruses / T cell clonality on vasculitis / vasculitogenic antibodies / vascular remodeling / angiogenesis / ゲノム / 感受性遺伝子 / 転写因子 / 自己抗体 / アポトーシス / ウイルス / CD72 / MPO / 高安動脈炎 / 原発性肺高血圧 / SNP / 血管炎感受性遺伝子 / ケモカインアンタゴニスト / HCMV / ANCA / 血管炎候補遺伝子 / 血管炎ゲノミクス / 血管炎モデル動物 / 血管炎原性ウイルス / 血管炎T細胞クロナリティー / 血管炎原性抗体 / 血管リモデリング / 血管新生 / oncofetal protein / tumor suppressor gene / hepatoid adenocarcinoma / 癌胎児性蛋白 / 癌抑制遺伝子 / 肝様腺癌 / Holmes' ataxia / CAG triplet repeat / spinocerebellar degeneration / ポリグルタミン鎖病 / Holmes失調症 / 遺伝性脊髄小脳変性症 / Holmes型失調症 / CAGリピート / 脊髄小脳変性症 / Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / パーフォリン / 自然免疫 / 自己免疫 / 多クローン性B細胞活性化 / STLV-1 / SIV / pX遺伝子 / p40 / IL-2受容体 / HIV / AIDS / 競合的RT-PCR / in situ hybridization / 副腎 / 臓器特異的発現 / 自己抗原 / 単クロン抗体 / 組み換え蛋白 / 診断基準 / 創始者効果 / 連鎖解析 / 遺伝子性脊髄小脳変性症 / 転移 / 膵癌 / SCIDマウス / Tax / トランスフォーメイション / 転写活性化因子 / HAM / HTLV-I / 転写活性化 / 成人T細胞白血病 / 塩基配列 / 蛋白発現ベクター / クロ-ニング / 慢性関節リウマチ / 癌化 / 胎盤 Less
  • Research Projects

    (27 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (77 People)
  •  動物モデルを用いたHTLV-1発がん機構の解析Principal Investigator

    • Principal Investigator
      吉木 敬
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  EXPRESSION OF HUMAN ENDOGENOUS RETROVIRUS AND ITS POSSIBLE ROLES FOR DEVELOPING AUTOIMMUNE DESIASES

    • Principal Investigator
      TOMARU Utano, 池田 仁
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  動物モデルを用いたHTLV-I発がん機構の解析Principal Investigator

    • Principal Investigator
      吉木 敬
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development and analyses of novel animal models for human retrovirus-induced desiases.Principal Investigator

    • Principal Investigator
      KYOSHIKI Takashi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  モデル動物を用いたHTLV-I発がんおよび関連疾患発症機構の解析Principal Investigator

    • Principal Investigator
      吉木 敬
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  モデル動物を用いたHTLV-I発がんおよび関連疾患発症機構の解析Principal Investigator

    • Principal Investigator
      吉木 敬
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Pathogenetic roles of human endogenous retroviruses in autoimmune diseases

    • Principal Investigator
      IKEDA Hitoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Molecular mechanisms of and novel pathomorphological bases on vasculitis syndromes

    • Principal Investigator
      NOSE Masato
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      Ehime University
  •  Analysis of HTLV-I-Associated Diseases using Animal ModelsPrincipal Investigator

    • Principal Investigator
      YOSHIKI Takashi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  PATHOGENETIC ROLE OF HTLV-I IN ANIMAL MODELS FOR HTLV-l-RELATED DISEASESPrincipal Investigator

    • Principal Investigator
      YOSHIKI Takashi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Mapping of the gene for Holmes' ataxia by searching of triplet repeats

    • Principal Investigator
      IKEDA Hitoshi, 脇坂 明美
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Identification of the gene for hereditary spinocerebellar degeneration and its usage for diagnosis.Principal Investigator

    • Principal Investigator
      YOSHIKI Takashi, 脇坂 明美
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Genetic changes in the transdifferentiation of gastric carcinoma : a study using hepatoid adenocarcinoma as a model

    • Principal Investigator
      ISHIKURA Hiroshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  自己免疫疾患における内在性レトロウイルスの病理学的意義に関する研究

    • Principal Investigator
      池田 仁
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  Research on Human Retrovirus as a Pathogenic Agents and its Treatment.Principal Investigator

    • Principal Investigator
      YOSHIKI Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  遺伝性脊髄小脳変性症における三塩基反復配列の探索

    • Principal Investigator
      脇坂 明美
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  ヒト内在性レトロウイルスに対する単クロン抗体の作製と発現細胞の同定に関する研究

    • Principal Investigator
      池田 仁
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  HTLV-1による細胞がん化の分子機構

    • Principal Investigator
      菅村 和夫
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  膵癌細胞の産生する血管内皮細胞活性化因子の検討

    • Principal Investigator
      ISHIKURA Hiroshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  ANALYSIS OF HTLV-I PATHOGENICITY USING ANIMAL MODELSPrincipal Investigator

    • Principal Investigator
      YOSHIKI Takashi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  HTLV-I感染症の動物モデル-HAMラットの分子病理学的解析Principal Investigator

    • Principal Investigator
      吉木 敬
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  ヒト内在性レトロウイルスの発現とその病因学的意義に関する研究

    • Principal Investigator
      池田 仁
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  ヒト内在性レトロウィルス遺伝子の病理学的意義、特に慢性関節リウマチへの関与

    • Principal Investigator
      脇坂 明美
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Hokkaido University
  •  Information Exchange on Cancer Research with North American Countries.

    • Principal Investigator
      YAMAGUCHI Nobuo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Institute of Medical Science, University of Tokyo
  •  ヒト内在性レトロウィルス遺伝子の病理学的意義

    • Principal Investigator
      WAKISAKA Akemi
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Hokkaido University
  •  宿主側から見た腫瘍増殖機序の分子免疫学的解析

    • Principal Investigator
      奥村 康
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University
  •  ヒトレトロウイルス感染リンパ球の遺伝子表現と宿主の免疫異常に関する基礎的研究

    • Principal Investigator
      白井 俊一
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Juntendo University

All 2005 2004 2003

All Journal Article

  • [Journal Article] Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene.2005

    • Author(s)
      Hayasa H, Ishizu A, Ikeda H, Miyatake Y, Baba T, Higuchi M, Abe A, Tomaru U, Yoshiki T.
    • Journal Title

      Int Immunol (in press)

    • NAID

      10019358360

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Differential modulation of gene expression among rat tissues with warm ischemia.2004

    • Author(s)
      Miyatake, Y., Ikeda, H., Michimata, R., Koizumi, S., Ishizu, A., Nishimura, N., Yoshiki, T.
    • Journal Title

      Exp Mol Pathol 77(3)

      Pages: 222-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Hematopoietic progenitor cells as possible origins of epithelial thymoma in a human T lymphocyte virus type I pX gene transgenic rat model.2004

    • Author(s)
      Tsuchikawa, T., Ikeda, H., Kikuchi, K., Tsuji, T., Baba, T., Ishizu, A., Tanaka, Y., Kate, H, Yoshiki, T.
    • Journal Title

      Lab Invest 84

      Pages: 245-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Bone marrow cells carrying the env-pX transgene play a role in the severity but not prolongation of arthritis in human T-cell leukaemia virus type-I transgenic rats : a possible role of articular tissues carrying the transgene in the prolongation of arthritis.2004

    • Author(s)
      Abe, A., Ishizu, A., Ikeda, H., Hayase, H., Tsuji, T., Miyatake, Y., Tsuji, M., Fugo, K., Sugaya, T., Higuchi, M., Matsuno, T., Yoshiki, T.
    • Journal Title

      Int J Exp Pathol 85(4)

      Pages: 191-200

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Dexamethasone increased plasminogen activator inhibitor-1 expression on human umbilical vein endothelial cells : an additive effect to tumor necrosis factor-alpha.2004

    • Author(s)
      Yamamoto, Y., Ishizu, A., Ikeda, H., Otsuka, N., Yoshiki, T.
    • Journal Title

      Pathobiology 71(6)

      Pages: 295-301

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Vaccination of fusion cells of rat dendritic and carcinoma cells prevents tumor growth in vivo.2003

    • Author(s)
      Kawada, M., Ikeda, H., Takahashi, T., Ishizu, A., Ishikura, H., Katoh, H., Yoshiki, T.
    • Journal Title

      Int J Cancer 105

      Pages: 520-526

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Provirus expansion and deregulation of apoptosis-related genes in the spinal cord of a rat model for human T-lymphocyte virus type I-associated myeloneuropathy.2003

    • Author(s)
      Tomaru, U., Ikeda, H., Jiang, X., Ohya, O., Yoshiki, T.
    • Journal Title

      J Neurovirol 9

      Pages: 530-538

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] In vitro model of suicide gene therapy for alpha-fetoproteinproducing gastric cancer.2003

    • Author(s)
      Nakaya, H., Ishizu, A., Ikeda, H., Tahara, M., Shindo, J., Itoh, R., Takahashi, T., Asaka, M., Hiroshi, I., Yoshiki, T.
    • Journal Title

      Anticancer Res. 23

      Pages: 3795-3800

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Epstein-Barr virus infection of rat lymphocytes expressing human CD21 results in restricted latent viral gene expression and not in immunoblastic transformation.2003

    • Author(s)
      Yang, L., Ikeda, H., Lat, Y., Yoshiki, T., Takada, K.
    • Journal Title

      J Med viral 70

      Pages: 126-130

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Tissue specific high level expression of a full length human endogenous retrovirus genome transgene, HERV-R, under control of its own promoter in rats.2003

    • Author(s)
      Tanaka, S., Ikeda, H., Otsuka, N., Yamamoto, Y., Sugaya, T., Yoshiki, T.
    • Journal Title

      Transgenic Research 12

      Pages: 319-328

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Transduction of dominant negative ATF-1 suppresses the pX gene expression in joint fibroblastic cells derived from HTLV-I transgenic rats.2003

    • Author(s)
      Ishizu, A., Tsuji, T., Abe, A., Saito, S., Takahashi, T., Ikeda, H., Meruelo, D., Yoshiki, T.
    • Journal Title

      Exp Mol Pathol 74

      Pages: 309-313

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • [Journal Article] Functional alteration of peripheral CD25^+CD4^+ immunoregulatory T cells in a transgenic rat model of autoimmune diseases.2003

    • Author(s)
      Higuchi, M., Ishizu, A., Ikeda, H., Hayase, H., Fugo, K., Tsuji, M., Abe, A., Sugaya, T., Suzuki, A., Takahashi, T., Koike, T., Yoshiki, T.
    • Journal Title

      J Autoimmunity 20

      Pages: 43-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590330
  • 1.  IKEDA Hitoshi (20232192)
    # of Collaborated Projects: 19 results
    # of Collaborated Products: 12 results
  • 2.  WAKISAKA Akemi (90113646)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 3.  ISHZU Akihiro (60321957)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 9 results
  • 4.  TOMARU Utano (20360901)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 5.  志田 壽利 (00144395)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  SHIBATA Masahiko (80301886)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  高橋 利幸 (40261284)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  FUJISAWA Jun-ichi (40181341)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  ISHIKURA Hiroshi (70222982)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  YOSHIDA Mituaki (80012607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SASAKI Hidenao (80281806)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  菅村 和夫 (20117360)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  内山 卓 (80151900)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  白井 俊一 (30115860)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  YAMAGUCHI Nobuo (90012723)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  HAMADA Hirofumi (00189614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KOUNO Kimitoshi (00153479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TAKAHASHI Takashi (50231395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TANIGUCHI Naoyuki (90002188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  IKEUCHI Taturou (90041839)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ISHIBASHI Masahide (70029776)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SIBUYA Masabumi (10107427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KATAOKA Tooru (40144472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  CHIDA Kazuhiro (00192188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NODA Tetuo (10183550)
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