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HIROHASHI Setsuo  廣橋 説雄

ORCIDConnect your ORCID iD *help
… Alternative Names

廣橋 説雄  ヒロハシ セツオ

広橋 説雄  ヒロハシ セツオ

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Researcher Number 70129625
Affiliation (based on the past Project Information) *help 2009: 国立がんセンター
2000 – 2001: 国立がんセンター, 研究所, 所長
1995 – 1999: 国立がんセンター研究所, 副所長
1997 – 1998: 国立がんセンター, 研究所, 副所長
1996: 国立がんセンター研究所, 病理部, 副所長 … More
1990 – 1994: 国立がんセンター研究所, 病理部, 部長
1990 – 1993: 国立がんセンター, 病理部, 部長
1992: 国立がンセ, 研, 部長
1991: 国立がんセンター研究所, 病理, 部長
1990: 国立がんセンター研究所, 病理, 室長
1988 – 1989: 国立がんセンター, 病理部, 室長
1987 – 1989: 国立がんセンター研究所, 病理部, 室長
1988: 国立がんセンター, 研究所・病理, 室長
1988: Pathology Division, National Cancer Center Research Institute, 室長
1987: 国立ガンセンター研究所, 室長
1986: 国立ガンセンター, 研究所・病理部・実験病理, 室長 Less
Review Section/Research Field
Principal Investigator
Human pathology
Except Principal Investigator
Biological Sciences / Public health/Health science
Keywords
Principal Investigator
c-erbB-2 / カドヘリン / 浸潤・転移 / hepatitis B virus / oncogene amplification / DNA extraction / formalin-fixed paraffin-embedded tissue / hst / cーexbBー2 / Nーmyc … More / 予後因子 / 癌遺伝子の増幅 / ドットブロット法 / ホルマリン固定パラフィン包理組織 / B型肝炎ウイスル / 肝癌 / c-myc / sam / 胃癌 / Coxの重回帰分析 / がんの悪性度 / 乳癌の予後因子 / polymerase chain reaction / B型肝炎ウイルス / がん遺伝子増幅 / DNA抽出 / ホルマリン固定パラフィン包埋組織 / signal transduction / tyrosine phosphorylation / integrin / catenin / cadherin / invasion and metastasis / cell adhesion / DNAメチル化 / カドヘリン・カテニン / 多段階発がん / がん間質相互作用 / シグナル伝達 / チロシンリン酸化 / インテグリン / カテニン / 細胞接着 / 胃がん / モノクロ-ナル抗体 / 細胞接着分子 / がんの分化度 … More
Except Principal Investigator
Stomach cancer / 胃がん / モノクローナル抗体 / テネイシン / 多段階発癌 / がん抑制遺伝子 / 大腸がん / 癌遺伝子 / Cancer / 口腔がん / がん / Lung cancer / Genetic factors / Risk factor / Histology / Case-control study / Brazil / 病理学 / 分子生物学 / 生体指標 / 症例対照研究 / 発がん要因 / 日系移民 / サンパウロ / 糖鎖抗原 / 大腸発がん / β-catenin / カテニン / カドヘリン / がん遺伝子 / 偶発がん / 潜在がん / 乳がん / 前立腺がん / 乳癌 / マ-カ-酵素変異 / 発癌のプログレッション / 癌関連遺伝子 / DNA ploidy / 大腸腺腫 / 大腸癌 / America / Asai / Aerum estrogen / Colorectal Cancer / Werner syndrome / Oral squarmous cell Carcinomas / Cholangiocellular Carcinoma / 南アジア / 東アジア / ウェルナ-症候群 / アメリカ / アジア / 血清エストロゲン値 / ウェルナー症候群 / 肝内胆管癌 / Central-South America / South-East Asia / China / Skin cancer / Liver cancer / Esophageal cancer / ホンコン / 肺がん / インドネシア / マレーシア / ギリシャ / フランス / EBウイルス / 中南米 / 東南アジア / 中国 / 皮膚がん / 肝がん / 食道がん / Cancer Metastasis / DNA Repair / Signal Transduction / Tumor Suppressor Genes / Oncogenes / German-Japanese Collaborative Program in Cancer Research / French-Japanese Collaborative Program in Cancer Research / International Exchange Program / がん抑制遣伝子 / がん遣伝子 / 2国間共同研究 / ヒトゲノム / DNA修復 / がん転移 / がん細胞 / シグナル伝達 / histo-in situ hybridization / 細胞動態 / DNAploidy / 癌形質 / 大腸菌線毛蛋白質 / 黒色腫関連糖鎖 / シアリルLe^a / モノクローナル抗体による血清診断 / 癌胎児性糖鎖 / 血清診断 / メラノーマ / ムチン / ガングリオシド / 癌関連抗原 / 癌診断 / 複合糖質 / 糖蛋白質 / 糖脂質 / 腫瘍マーカー / 単クローン抗体 / 腫瘍関連抗原 / ウィルス / 細胞組織 / 遺伝子 / 細胞・組織 / ゲノム / 癌 / ウイルス / 遺伝学 / Wntシグナル / GeneChip / TCF4 / APC / c-Src / ARFGAP / p130Cas / チロシンリン酸化 / アクチン細胞骨格再構成 / membrane ruffle / RhoGAP / RhoA / paxillin / プラコグロビン / βカテニン / パキシリン / Rho-family GTPases / 浸潤性 / F9 / P120 / 浸潤 / 細胞運動 / インテグリン / 家族性大腸腺腫症 / T-cell factor-4 / multidrug resistance-1 (MDR1) gene / P-glycoprotein / 評価 / 外国側研究者 / ベトナム / ハンガリー / 北欧 / 胆嚢がん / 予備調査 / 計画研究 / 転写因子結合部位 / 転写調節領域 / 染色体7番 / CDDP / cisplatin / がん薬剤耐性 / Semaphorin E / 扁平上皮がん / BP180 / 類天疱瘡患者 / hemidesmosome / 基底膜 / 基底細胞 / 扁平上皮 / c-erbB-2 / インターフェロン / アポトーシス / HGF / lef / Tcr / β-カテニン / c-ERBB2遺伝子 / 6-16遺伝子 / ヒト消化器がん / cycloheximide / 5-FU / cytochrome c / caspase-3 / Bcl-2 / CIB / apoptosis / 6-16 gene / ホルモン / 癌抑制遺伝子 / nm23 / Ag-NOR / rasがん遺伝子 / p53癌抑制遺伝子 / アンドロゲン受容体 / AgーNOR / ras癌遺伝子 / 潜在癌 / 前立腺癌 / flat adenoma / インテグリン抗体 / 原因遺伝子 / 腎癌 / 肺癌 / 肝細胞癌 / 癌胎児性変化 / RNAスプライシング / フィブロネクチン / 細胞外基質 / UEAー1レセプター / 増殖帯 / allelic loss / 背景粘膜 Less
  • Research Projects

    (29 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (111 People)
  •  Genetic and Epigenetic Dysregulation in Cancer

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
      Tohoku University
  •  TCF4とβ-catenin複合体により転写活性化される遺伝子の同定と機能解析

    • Principal Investigator
      山田 哲司
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  TCF4とβ-catenin複合体により転写活性化される遺伝子群の同定

    • Principal Investigator
      山田 哲司
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  細胞接着シグナルを介したがん細胞の浸潤制御機構

    • Principal Investigator
      佐邊 壽孝
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka Bioscience Institute
  •  インターフェロン誘導6-16遺伝子の発現とその機能解析

    • Principal Investigator
      田原 榮一 (川原 榮一)
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hiroshima University
  •  がん特別調査に関する総括研究

    • Principal Investigator
      OHNO Yoshiyuki
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya University
  •  Semaphorin E誘導によるがん薬剤耐性機構の解明と臨床的意義の検討

    • Principal Investigator
      山田 哲司
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Planning-Coordination Committe on Special Cancer Research

    • Principal Investigator
      OHNO Yoshiyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Public health/Health science
    • Research Institution
      NAGOYA UNIVERSITY
  •  ヘミデスモゾーム蛋白BP180を介した扁平上皮の増殖分化制御とその癌化に伴う異常

    • Principal Investigator
      YAMADA Tesshi
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Intercellular interaction and signal transduction in cancer morphogenesisPrincipal Investigator

    • Principal Investigator
      HIROHASHI Setsuo
    • Project Period (FY)
      1995 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      National Cancer Center Research Institute
  •  General Studies on Special Cancer Research

    • Principal Investigator
      TOMINAGA Suketami
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Aichi Cancer Center Research Institute
  •  前立腺がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展

    • Principal Investigator
      矢谷 隆一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  Case-control study for gastric cancer among Japanese and non-Japanese groups in Brazil

    • Principal Investigator
      WATANABE Shaw
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      National Cancer Center Research Institute
  •  前立線がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展

    • Principal Investigator
      矢谷 隆一
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  前立腺がんおよび乳がんにおける潜伏がんならびに微小がんの発生と進展

    • Principal Investigator
      矢谷 隆一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Mie University
  •  Cooperation and information exchange with European countries.

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      University of Tokyo
  •  Epidemiologic study on gastric cancer among Japanese and non-Japanese groups South America

    • Principal Investigator
      WATANABE Shaw, 渡邉 昌
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      National Cancer Center Research Institute
  •  多段階発癌過程における癌関連遺伝子の変化

    • Principal Investigator
      KITAGAWA Tomoyuki
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  ヒト固型がんの分化度と細胞接着分子の発現異常Principal Investigator

    • Principal Investigator
      広橋 説雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  多段階発癌過程における癌関連遺伝子の変化

    • Principal Investigator
      北川 知行
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  多段階発癌過程における癌関連遺伝子の変化

    • Principal Investigator
      北川 知行
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  ヒト大腸癌の発生と進展に関する細胞生物学的研究

    • Principal Investigator
      森 武貞
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  ヒト癌におけるalternative splicingの脱制御の検証

    • Principal Investigator
      関口 清俊
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Fujita Health University
  •  ヒト大腸癌の発生と進展に関する細胞生物学的研究

    • Principal Investigator
      森 武貞
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  ヒト大腸癌の発生と進展に関する細胞生物学的研究

    • Principal Investigator
      森 武貞
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Extraction of DNA from formalin-fixed paraffin-embedded tissues and its application to the study of molecular pathology.Principal Investigator

    • Principal Investigator
      HIROHASHI Setsuo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      National Cancer Center Research Institute
  •  腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  腫瘍マーカーとしての糖鎖特異的単クローン抗体の作成とその応用

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo

All 2010 2009 2007 2006 2005 2004

All Journal Article

  • [Journal Article] Significance of PGP9. 5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma2010

    • Author(s)
      Y. Akishima-Fukasawa, Y. Ino, Y. Nakanishi, A. Miura, Y. Moriya, T. Kondo, Y. Kanai, S. Hirohashi
    • Journal Title

      Am. J. Clin. Pathol. 134

      Pages: 71-79

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma2009

    • Author(s)
      T. Yamanashi, Y. Nakanishi, G. Fujii, Y. Akishima-Fukasawa, Y. Moriya, Y. Kanai, M. Watanabe, S. Hirohashi
    • Journal Title

      Oncology. 77

      Pages: 53-62

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.2007

    • Author(s)
      H. Katoh, S. Hirohashi, et. al. (total 11, 10th)
    • Journal Title

      Gastroenterology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics2006

    • Author(s)
      T.Kondo, S.Hirohashi
    • Journal Title

      Nature Protocols 1(6)

      Pages: 2940-2956

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis : its association with clinicopathological features.2005

    • Author(s)
      T.Shibata, S.Hirohashi et al.(total 13, last)
    • Journal Title

      Clinical Cancer Res. 11(17)

      Pages: 6177-6185

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.2005

    • Author(s)
      S.Hirohashi.(他8名)
    • Journal Title

      Gastroenterology 128(1)

      Pages: 51-62

    • Data Source
      KAKENHI-PROJECT-16059101
  • [Journal Article] Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.2004

    • Author(s)
      S.Hirohashi.(他8名)
    • Journal Title

      Cancer Res. 64(19)

      Pages: 6989-6995

    • Data Source
      KAKENHI-PROJECT-16059101
  • 1.  KITAGAWA Tomoyuki (50085619)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  YAMADA Tesshi (30221659)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KUROKI Toshio (90006073)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  加藤 洋 (20010473)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  藤田 哲也 (00079716)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OHNO Yoshiyuki (10160590)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YAMAMOTO Tadashi (40134621)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  HANAOKA Fumio (50012670)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  森 武貞 (60028496)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  喜納 勇 (60010211)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  佐藤 栄一 (60004579)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  佐藤 清美 (50006079)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  小川 勝洋 (50045514)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 14.  矢谷 隆一 (80024636)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 15.  島崎 淳 (10008229)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 16.  坂元 吾偉 (80085620)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 17.  永井 克孝 (80072974)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 18.  松本 亮 (70046241)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 19.  内貴 正治 (10020752)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 20.  谷口 克 (80110310)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 21.  坂倉 照好 (80073120)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  FUJIKI Hirota (60124426)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 23.  ISHIKAWA Fuyuki (30184493)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 24.  YAMAMOTO Masayuki (50166823)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 25.  NAKAMURA Takuro (00180373)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 26.  SHIMOTONO Kunitada (10000259)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 27.  WATANABE Shaw (60051637)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 28.  WAKABAYASHI Kenji (60158582)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 29.  TSUGANE Shoichiro (40179982)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 30.  YOSHIDA Mitsuaki (80012607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 31.  白井 智之 (60080066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 32.  酒井 正春 (50162269)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 33.  寺田 信行 (50150339)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 34.  千谷 晃一 (60179942)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 35.  LAURENTI Ruy
    # of Collaborated Projects: 2 results
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  • 111.  HUMBERTO Torloni
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