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MATSUDA Akira  松田 彰

ORCIDConnect your ORCID iD *help
Researcher Number 90157313
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2014: 北海道大学, 薬学研究科(研究院), その他
2013: 北海道大学, 薬学研究科(研究院), 特任教授
2012: 北海道大学, 薬学研究科(研究院), 教授
2006 – 2011: 北海道大学, 大学院・薬学研究院, 教授
2006: 北海道大学, 大学院薬学研究院, 教授 … More
2005: 北海道大学, 大学院薬学研究科, 教授
1999 – 2005: Hokkaido University, Graduate School of Pharmacy, Professor, 大学院・薬学研究科, 教授
1999: 北海道大学, 薬学部, 教授
1998: 北海道大学, 大学院薬学研究科, 教授
1998: 北海道大学, 薬学研究科, 教授
1991 – 1997: 北海道大学, 薬学部, 教授
1990: 北海道大, 薬学部, 助教授
1986 – 1990: 北海道大学, 薬学部, 助教授
1989: 北海道大学, 薬学部, 教授
1986: Faculty of Pharmaceutical Sciences, Instructor, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Drug development chemistry / 医薬分子機能学 / Biological Sciences / Biological pharmacy
Except Principal Investigator
Chemical pharmacy / Biological pharmacy / 応用薬理学・医療系薬学 / Basic veterinary science/Basic zootechnical science / Applied veterinary science / Physical pharmacy / 寄生虫学(含医用動物学) / 寄生虫学(含医用動物学)
Keywords
Principal Investigator
ヌクレオシド / アポトーシス / 代謝拮抗剤 / ヌクレアーゼ抵抗性 / オリゴヌクレオチド / CNDAC / thermal stability / レチノイド / DNAポリメラーゼ / DNA鎖切断 … More / 逆転写酵素 / SELEX / 制限酵素 / アデノシン / Nucleoside / アプタマー / 4'-チオDNA / 4'-チオ核酸 / シスプラチン / ECyd / 放射線 / 固形がん / サイクリックADPリボース / ネオカルチノスタチン / 生体高分子 / マラリア / シチジンデアミナーゼ / デオキシシチジンキナーゼ / 制癌性ヌクレオシド / DNAポリメラ-ゼ / DNA synthesis / Molecular Recognition / Restriction enzyme / DNA polymerase / Nucleoside tautomerism / Mutagegenicity / Oligonucleotide / 5-ハロゲノシトシン / ワーデアザアデニン / 相互作用 / メチル化酵素 / 6-アザシトシン / DNA-シトシンメチル化酵素 / DNA / Klenow fragment / 変異原性 / 互変異性体 / Palladium catalyst / Spontaneous hypertensive rat / Hypotensive activity / Adenosine / 2-Alkynyladenosine / 降圧作用 / アデノシンデアミナーゼ / アデノシンレセプター / クロスカップリング / パラジウム触媒 / 自然発症高血圧ラット / 血圧降下作用 / 2-アルキニルアデノシン / KOD dash / 4'-thioDNA / aptamer / 4'-thioRNA / 4'-thonucleoside / nuclease stability / 4-チオ核酸 / RNase A耐性 / 4-チオRNA / 分子認識 / Rnase A耐性 / T7 RNA polymerase / 酵素合成 / VEGF / 4'-チオRNA / foot printing / reverse Hoogsteen / Hoogsteen / hydrogen bond / triple helix / antigene / pentaerythritol / アントラキノン / インターカレーター / オリゴプリン配列 / オリゴピリミジン配列 / ペンタエリスリトール / ゲル電気泳動 / アンチジーン法 / phosphodiester bond / oligodeoxyribonucleotide / 4'-branched thymidine / radical cyclization / antisense molecule / endo-nuclease / exo-nuclease / RNaseH / ラジカル反応 / リン酸ジエステル結合 / 熱的安定性 / RNase H / アンチセンス核酸 / channel blocker / cyclopropane / conformational restriction / neuronal cell death / NMDA receptor / 分子設計 / 遅発性神経細胞死 / セロトニントランスポーター / 立体配座固定 / アンタゴニスト / NMDAレセプター / チャネルブロッカー / シクロプロパン / 配座制御 / 神経細胞死 / NMDA受容体 / methyl acrylate / facial selectivity / adenosine / high-pressure / Diels-Alder reaction / phosphodiesterase / griseolic acid / グリゼオール酸 / 位置選択性 / 面選択性 / 立体選択的合成 / ディールス・アルダー反応 / 超高圧 / ホスホジエステラーゼ / Diels-Alder反応 / 3-Deazaaristeromycin / Ribavirin / 5-ethynyl-1-beta-D-ribo-furanosylimidazole-4 / Antimetabolite / Chemotherapy / RNA-virus / EICA / EICAR / 抗ウィルス薬 / RSウィルス / RNA型ウィルス / 5ーエチニル・1ーβーDーリボフラノシルイミダゾ-ルー4ーカルボキサミド / RNAウイルス / エチニルー1ーβーDーリボフラノシルイミダゾ-ルー4ーカルボキサミド / 3ーデアザアリステロマイシン / リバビリン / ゾ-ルー4ーカルボキサミド / 化学療法剤 / 急性呼吸器疾患 / RNAウィルス / ラジカル還元反応 / メチルオキザリルエステル / グリニア反応 / 立体選択性 / 分枝糖ヌクレオシド / ホスホジエステル結合 / ホスホロチオエート結合 / shRNA / アンチマイクロRNA / 2'-OMe-4'-チオリポヌクレオシド / 核酸創薬 / stat3 / DNMT1 / SPAAC / PSMA / 組織標的化 / 核酸医薬 / マクロビノサイトーシス / 2'-0-メチル-4'-チオリポヌクレオシド / マクロピノサイトーシス / 膜透過性ペプチド / RNAi / 2'-0-メチル-4'-チオリボヌクレオシド / antisense RNA / si RNA / NMR / ヌクレアーゼ祇抗性核酸 / RNA干渉 / ゲノム創薬 / リポソーム / Dicer / ホタルルシフェラーゼ / 2'-O-メチル-4'-チオリボヌクレオシド / Apo-B / コレステロール / miRNA / MEND / SNALP / 2'-O-メチル-4'-チオリポヌクレオシド / ヌクレアーゼ抵抗性核酸 / 薬物送達システム / ベクター / siRNA / 代謝酵素 / in vivo / in vitro / gemcitabine / JNK / サバイビン / INF-2α / HIF-1α / 修復 / DNA損傷 / 28S rRNA / c-Jun N-terminal kinase / RNase L / G2アレスト / RNAポリメラーゼ / Ecyd / 4'-チオシチジン誘導体 / DNA(cytosine-5)methyltransferase / デコイ核酸 / 核酸代謝酵素 / ウリジン・シチジンキナーゼ / z-VAD-fmk / トランスロケーション / Bax / ミトコンドリア / 4-チオリボヌクレオシド / HMG蛋白 / M期checkpoint / G2 / X線 / ネクローシス / Bcl-2 / UCK-2 / Chk1 / survivin / 併用効果 / エンジイン / 血管新生 / ドラッグデザイン / RNA合成阻害剤 / p53 / カスパーゼ / 抗がん剤 / タキソ-ル / ハリコンドリンB / タキリ-ル / ハリコンンドリンB / ハービマイシンA / TPA / アンチセンスオリゴヌクレオチド / 血管新生阻害 / がん転移 / フィブロネクチン / G-蛋白質 / 鎖切断 / 核酸代謝 / ヌクレアーゼ / 光酸化反応 / DMDC / 寄生原虫 / HIV / AIDS / シアノ基 / ヌクレオチド / 化学合成 / 制癌作用 / シルシトシン(CNDAC) / 2'ーシアノー2'ーデオキシー1ーβーDーアラビノフラノ / 立体配座 / アジドチミジン / 抗HIV活性 … More
Except Principal Investigator
ヌクレオシド / 核酸代謝拮抗剤 / 構造 / 核酸 / TUMOR CELL LINES / NECROSIS / CELL DEATH / CASPASE / APOPTOSIS / ANTICANCER DRUG / LYMPHOMA / LEUKEMIA / 株化ガン細胞 / ネクローシス / 細胞死 / カスパーゼ / アポトーシス / 制癌剤 / リンパ腫 / 白血病 / GDNF / aging / PEPT1 / Caco-2 / Screening / プロテインキナーゼC / 老化促進マウス / 老化 / 老化促進モデルマウス / PET / マラリア / 抗腫瘍性 / CNDAC / 多機能化ヌクレオシド / アンチセンス核酸 / 遺伝子 / 分子設計 / 有機化学 / 機能 / RNA / DNA / ヌクレオシドアナログ / イノシンアナログ / リーシュマニア / 原虫 / 代謝拮抗剤 / Leishmania tropica, / 3'-Deoxyinosine / Carbocyclic inosin 3'-deoxy-3'-fluoroinosine / Nucleoside analogues / Anti-Leishmania / Anti-parasitic agents / 3'-デオキシイノシン / 化学療法剤 / 熱帯病 / カーボサイクリックイノシン / 3´-デオキシイノシン / 抗寄生原虫剤 / 病原寄生原虫 / Ribonuclease / Nucleoside conformation / Cyclonucleosides / Stereochemistry / Nucleotides / Nucleosides / アデノシンデアミナーゼ / リボヌクレアーゼ / ヌクレオシドのコンフォーメーション / シクロヌクレオシド / ヌクレオシドの立体化学 / ヌクレオチド / quantification / transcriptional efficiency / adeno-virus / endocytosis / intracellular trafficking / 体内動態制御 / 細胞内動態制御 / ウイルスベクター / 非ウイルスベクター / ライソゾーム / エンドソーム / 共焦点レーザー顕微鏡 / 定量的評価 / 転写効率 / アデノウイルス / エンドサイトーシス / 細胞内動態 / neuronal death / ischemia / depressive behavior / learning impairments / senescence accelerated mouse / NO / アポートシス / ストレス刺激 / 受容体 / 神経伝達物質 / 虚血モデル / 促進老化マウス / グルタミンシンテターゼ / differential display法 / senescence accelerated mouse(SAM) / 加齢 / 神経細胞死 / 脳虚血 / うつ病 / 学習記憶障害 / senescence accelerated mouse (SAM) / target molecule / Plasmodium falciparum / protozoa / tropical fever / antisense / Anti-malaria drug / Malaria / インターネット / 熱帯熱マラリア / スクリーニンヅ / マラリア治療薬 / ATPase / ミトコンドリア / 標的分子 / P.falciparum / 熱帯熱 / アンチセンス / スクリーニング / 抗マラリア薬 / SAM mouse / muscarinic antagonist / muscarinic ACh receptor / acetylcholine (ACh) / dementia / memory / learning / 空間認知機能改善作用 / [^3H]PDBu結合 / Moris's water maze / SAMP8系マウス / lithospermic acid B / 丹参 / 記憶・学習 / ラット / アセチルコリン受容体 / アセチルコリン / 痴呆 / 記憶 / 学習 / anti-cancer drugs / multi-efflux transporter / methoxylate / fluorescent substrate / Peptide transporter / フローレセッイン / ロ-ダミン123 / ピレン / 平面脂質二分子膜 / リゾリン脂質 / 膜輸送 / 腸管吸収 / ザルコシン / Sw620 / Caco2 / FITC / ダイペプチド / 蛍光性輸送基質 / 抗ガン剤 / 多剤排出輸送体 / メトキサレート / 蛍光生輸送基質 / ペプチドトランスポータ / Neurochmistry / Pharmacology / Herbs / Therapeutics / Memory disturbance / Mouse / Aging / GABA受容体 / NMDA型グルタミン酸受容体 / M_1ムスカリン受容体 / 海馬 / 脳機能障害 / 薬効評価法 / 神経伝達物質受容体 / 脳内機序 / 薬理学 / 神経化学 / 薬効評価 / 和漢薬 / 予防治療薬 / 記憶障害 / 化学合成 / 制癌作用 / 分枝糖ヌクレオシド / 2^1-デオキシ-2^1-メチリデンシチジン / DNAチップ / アロディニア / PGE_2 / リアノジン受容体 / 15R-TIC / リピドA / サリドマイド / Cu-ATSM / ダントロレン誘導体 / 4'-チオリボヌクレオシド / 可視化プローブ / RXRアンタゴニスト / プロスグランジン / 34mCl / キナーゼ阻害剤 / レチノイド / 光親和性標識法 / MicroPET / プラナーポジトロンイメージング / 神経性疼痛 / Socius / ABCトランスポーター / non-RI光親和性標識法 / 3成分連結PG合成法 / シグナル解析 / 神経因性疼痛 / 阻害剤 / キナーゼ / 人工核酸 / 蛍光プローブ / 高速メチル化 / 受容体リガンド / 有機合成 / 分子プローブ / 脳 / イメージング / in vivo / プロスタグランジン / 固形腫瘍 / RNA合成阻害 / DNA合成阻 / エチニルシチジン / エチニルウリジン / 多機能性ヌクレオシド / ベクターコントロール / ドラッグデザイン / ワクチン / 化学療法 / 分子寄生虫学 / 寄生体 / 熱帯感染症 / ヒトがん細胞 / M5076肉腫 / Pal‐CNDAC / CTP合成酵素阻害剤 / ヒト線維肉腫細胞HT-1080 / deoxycytidine kinase / DMDC / がん化学療法剤 / 核酸水素給合 / 核酸合成 / 核酸高次構造 / 機能性核酸 / NMR / 核酸有機化学 / 核酸構造 / マクロファ-ジ / リポソ-ム / リ-シュマニア / SDDS / 駆虫薬 / マクロファージ / リポリーム / ヌクレオシド・アナログ / オリゴヌクレオチド / リボザイム / 抗HIV作用 / MT-4細胞 / D4C / D4T / アジドチミジン / HIV / エイズ / ヌ-ドマウス / 構造-活性相関 / アリ-ルアルコ-ル / がん化学療法 Less
  • Research Projects

    (47 results)
  • Research Products

    (74 results)
  • Co-Researchers

    (85 People)
  •  Targeting of the nuclease-resistant functional oligonucleotidesPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotidesPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Design of Nucleosides Antitumor AgentsPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Basic Studies of Molecular Recognition by 4'-Thionucleic acidsPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  生物新機能と創薬をめざす生体内分子科学

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Gifu University
  •  Synthesis of new functionalized nucleic acids by the pentaerythritol linker.Principal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery system

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  構造、配列、代謝情報を基盤とする抗がん性核酸誘導体の設計Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  生体内分子科学

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Creative Basic Research
    • Research Institution
      Gifu University
  •  Development of new antitumor drugs and apoptotic signal transudation - Application to feline leukemia and canine lymphoma -

    • Principal Investigator
      KUWABARA Mikinori
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Development of antitumor drugs to enhance apoptotic cell death and clinical application

    • Principal Investigator
      INANAMI Osamu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  ドラッグデザインによる新しい抗がん剤の合成Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  Design of Nuclease-resistant Antisense Molecules Based on the X-ray Structures of Some NucleasesPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      医薬分子機能学
    • Research Institution
      Hokkaido University
  •  Development of model animals and cells for neuronal disease

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  生体高分子機能を修飾する抗がん化合物の合成と作用解析Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  新規多機能性エチニルヌクレオシド類の抗腫瘍性と作用機序

    • Principal Investigator
      佐々木 琢磨
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kanazawa University
  •  Development of Anti-malarial Drug and it's Molecular Target

    • Principal Investigator
      WATAYA Yusuke
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Okayama University
  •  A study on development of inhibitors for neuronal cell deathPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  生体高分子機能を修飾する抗がん化合物の合成と作用解析Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  多機能化ヌクレオシドの抗腫瘍活性の解析と応用

    • Principal Investigator
      佐々木 琢磨
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kanazawa University
  •  重要熱帯病マラリア制圧に向けた分子生物学的研究

    • Principal Investigator
      小島 荘明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      The University of Tokyo
  •  Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes

    • Principal Investigator
      KAMO Naoki
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Establishment and estimation of pharmacological bioassay system for therapeutic drugs of aging in central nervous system.

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  非細胞傷害性抗がん化合物の合成と作用解析Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  多機能化ヌクレオシドの抗腫瘍活性の解析と応用

    • Principal Investigator
      佐々木 琢磨
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kanazawa University
  •  Highly Stereoselective Synthesis of Bicyclic-sugar Adenosine Derivatives via Diels-Alder Reaction.Principal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  機能の創生を目指すヌクレオシドの化学合成Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  新規抗腫瘍性ヌクレオシドCNDACの作用機序の解明と新規代謝拮抗剤の設計Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  新規抗腫瘍性ヌクレオシドDMDCおよびCNDACの作用機序の解明Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  核酸の構造と機能の有機化学的展開(成果とりまとめ)

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  アンチセンス核酸の活性と水素結合の機能の研究

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  Studies on the Machanism of Memory Disturbances in Senescence-Accelerated Mouse and the Application to Screening of Nootropics

    • Principal Investigator
      NOMURA Yasuyuki
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Hokkaido University
  •  機能の創生を目指すヌクレオシドの化学合成Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  逆転写酵素阻害を基本戦略とする抗HIV剤の開発研究Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  DNA鎖自己切断能をもつヌクレオシド系自殺基質の設計Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Tokyo Institute of Technology
  •  リポリームなどDDSの工夫を加えたヌクレオシド系抗寄生原虫剤の開発研究

    • Principal Investigator
      ISHII Akira
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      国立予防衛生研究所
  •  不合飽和官能基をもつヌクレオシドの制癌活性機序

    • Principal Investigator
      TOHRU Ueda
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  逆転写酵素阻害を基本戦略とする抗HIV剤の開発研究

    • Principal Investigator
      上田 亨
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Developmental Studies of Nucleosidic Anti-RNA Virus DrugsPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira, 上田 亨
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B).
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  新しい制癌作用機序を有する分枝糖ヌクレオシドの合成

    • Principal Investigator
      上田 亨
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Interactions Between Oligodeoxyribonucleotides and Their Utilizing EnzymesPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira, 上田 亨
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  分枝糖ヌクレオシドの立体選択的合成Principal Investigator

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  Developmental studies of hypotensive adenosine derivativesPrincipal Investigator

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  Anti-Parasitic Activity of Nucleoside Analogues against Leishmania tropica and Leishmania donovani.

    • Principal Investigator
      WATAYA Yusuke
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      Okayama University, Faculty of Pharmaceutical Sciences
  •  Stereochemical Studies of Nucleosides and Nucleotides

    • Principal Investigator
      TOHRU Ueda
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University

All 2015 2014 2013 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book Patent

  • [Book] Chemical Biology of Nucleic Acids, RNA Technologies,2014

    • Author(s)
      Minakawa, N.; Matsuda, A.
    • Total Pages
      599
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Book] Curr. Protoc. Nuceic Acid Chem.2014

    • Author(s)
      Minakawa, N.; Matsuda, A.
    • Total Pages
      15
    • Publisher
      Wiley
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Book] 次世代がん戦略研究update がん基盤生物学―革新的シーズ育成に向けて-2013

    • Author(s)
      松田彰、清木元治、秋山徹、石川冬木、内海潤、近藤豊、中山敬一、平尾敦
    • Total Pages
      336
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Book] 核酸創薬:CSJカレントレビュー06,核酸化学のニュートレンド2011

    • Author(s)
      松田彰
    • Total Pages
      218
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Book] siRNA分子のデザインとターゲッテング:『がん分子標的治療研究-実践マニュアル』(日本がん分指標的治療学会編集(曽根三郎、鶴尾隆編集代表))2009

    • Author(s)
      南川典昭、松田彰
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Book] Modified Nucleosides : in Biochemistry, Biotechnology and Medicine2008

    • Author(s)
      A. Matsuda,
    • Publisher
      Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Book] 核酸医薬の創製をめざして : 「バイオとナノの融合II,新生命科学への応用」(北海道大学COE研究成果編集委員会)2007

    • Author(s)
      松田彰, 南川典昭
    • Publisher
      北海道大学
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Book] 化学フロンテイア『創薬をめざす有機合成戦略:進化する医薬品づくり』(スーパー核酸:4'-チオ核酸の合成から核酸医薬開発に向けた基礎研究の展開, 宍戸宏造、新藤充編)2007

    • Author(s)
      南川典昭, 松田彰
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Book] 核酸医薬の創製をめざして:『バイオとナノの融合II, 新生命科学への応用』2007

    • Author(s)
      松田 彰
    • Publisher
      北海道大学COE研究成果編集委員会
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Book] スーパー核酸 : 4'-チオ核酸の合成から核酸医薬開発に向けた基礎研究の展開,化学フロンテイア「創薬をめざす有機合成戦略 : 進化する医薬品づくり」(宍戸, 宏造, 新藤, 充)2007

    • Author(s)
      南川典昭, 松田彰
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Transcription of 4’-thioDNA templates to natural RNA in vitro and in mammalian cells.2015

    • Author(s)
      Maruyama, H.; Furukawa, K.; Kamiya, H.; Minakawa, N.; Matsuda, A.
    • Journal Title

      Chem. Commun.

      Volume: 51 Issue: 37 Pages: 7887-7890

    • DOI

      10.1039/c4cc08862j

    • NAID

      120005714777

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25282144, KAKENHI-PROJECT-15H04656
  • [Journal Article] First synthesis of fully modified 4'-selenoRNA and 2'-OMe-4'-selenoRNA based on the mechanistic considerations of an unexpected strand break.2014

    • Author(s)
      Tarashima, N.; Hayashi, K.; Terasaki, M.; Tanike, H.; Inagaki, Y.; Fukuda, Y.; Furukawa, K.; Matsuda, A.; Minakawa,
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 18 Pages: 4710-4713

    • DOI

      10.1021/ol502077h

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-24390027
  • [Journal Article] An intracellular buildup reaction of active siRNA species from short RNA fragments.2014

    • Author(s)
      Maruyama, H.; Nakashima, Y.; Shuto, S.; Matsuda, A.; Itoh, Y.; Abe, H.
    • Journal Title

      Chem. Commun.

      Volume: 50 Issue: 11 Pages: 1284-1287

    • DOI

      10.1039/c3cc47529h

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25282240
  • [Journal Article] Selective transcription of an unnatural naphthyridine:imidazopyrimidine base pair containing four hydrogen bonds by using T7 RNA polymerase.2014

    • Author(s)
      Nomura, Y.; Kashiwagi, S.; Sato, K.; Matsuda, A.
    • Journal Title

      Angew. Chem. Int. Ed. Engl.

      Volume: 53 Issue: 47 Pages: 12844-12848

    • DOI

      10.1002/anie.201406402

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25410165
  • [Journal Article] The systemic administration of an anti-miRNA oligonucleotide encapsulaed pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice2014

    • Author(s)
      Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
    • Journal Title

      J. Control. Release

      Volume: 173 Pages: 43-50

    • DOI

      10.1016/j.jconrel.2013.10.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
  • [Journal Article] Chemistry, Properties, and in Vitro and in Vivo Applications of 2'-O-Methoxyethyl-4'-thioRNA, a Novel Hybrid Type of Chemically Modified RNA2014

    • Author(s)
      Saito, Y.; Hashimoto, Y.; Arai, M.; Tarashima, N.; Miyazawa, T.; Miki, K.; Takahashi, M.; Furukawa, K.; Yamazaki, N.; Matsuda, A.; Ishida,T.; Minakawa, N.
    • Journal Title

      ChemBioChem

      Volume: 15 Issue: 17 Pages: 2535-2540

    • DOI

      10.1002/cbic.201402398

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J06728, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-26107713
  • [Journal Article] Incorporation of 2'-deoxy-2'-isonucleoside 5'-triphosphates into DNA by A-and B-family DNA polymerases with different recognition mechanisms.2010

    • Author(s)
      Ogino T.; Sato K.; Matsuda A.
    • Journal Title

      ChemBioChem. 11

      Pages: 2597-2605

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Convenient RNA synthesis using a phosphoramidite possessing a biotinylated photocleavable group.2010

    • Author(s)
      Tomaya K.; Takahashi M.; Minakawa N.; Matsuda A.
    • Journal Title

      Org.Lett. 12

      Pages: 3836-3839

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Selective detection of 5-formyl-2'-deoxyuridine, an oxidative lesion of thymidine, in DNA by a fluorogenic reagent2010

    • Author(s)
      Hirose W., Sato K., Matsuda A.
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 49

      Pages: 8392-8394

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Selective recognition of unnatural imidazopyridopyrimidine : naphthyridine base pairs consisting of four hydrogen bonds by the Klenow fragment.2009

    • Author(s)
      Minakawa N.; Ogata S.; Takahashi M.; Matsuda A.
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 1644-1645

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] PK-PD modeling of 1-(3-C-ethynyl- β-D-ribo-pentofuranosyl )- cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes.2009

    • Author(s)
      A.Takada, H.Kamiya, S.Shuto, A.Matsuda, H.Harashima
    • Journal Title

      Int.J.Pharm. 377

      Pages: 52-59

    • NAID

      120001452161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Three-dimensional structure-activity relationship study of belactosin A andits stereo- and regioisomers: development of potent proteasome inhibitorsby a stereochemical diversity-oriented strategy.2009

    • Author(s)
      K.Yoshida, K.Yamaguchi, A.Mizuno, Y.Unno, A.Asai, T.Sone, H.Yokosawa, A.Matsuda, M.Arisawa, S.Shuto
    • Journal Title

      Org.Bio.Chem. 7

      Pages: 1868-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability.2009

    • Author(s)
      Takahashi M.; Minakawa N.; Matsuda A.
    • Journal Title

      Nucleic Acids Res. 37

      Pages: 1353-1362

    • NAID

      120003260045

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] ECyd (TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo.2009

    • Author(s)
      H.Kazuno, A.Fujioka, M.Fukushima, Y.W ataya, A.Matsuda, T.Sasaki
    • Journal Title

      Int.J.Oncol 34

      Pages: 1373-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Unnatural imidazopyridopyrimidine : naphthyridine base pairs : selective incorporation and extension reaction by Deep Vent (exo-) DNA polymerase.2009

    • Author(s)
      Ogata S.; Takahashi M.; Minakawa N.; Matsuda A.
    • Journal Title

      Nucleic Acids Res. 37

      Pages: 5602-5609

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Synthesis and characterization of 2'-modified-4'-thioRNA : a comprehensive comparison of nuclease stability2009

    • Author(s)
      Takahashi, M. ; Minakawa, N. ; Matsuda, A.
    • Journal Title

      Nucleic Acids Res. 37

      Pages: 1353-1362

    • NAID

      120003260045

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Investigations toward the selection of fullymodified 4'-thioRNA aptamers : optimization of in vitro transcription step in the presence of 4'-thioNTPs.2008

    • Author(s)
      Minakawa N.; Sanji M.; Kato Y.; Matsuda A.
    • Journal Title

      Bioorg.Med.Chem. 16

      Pages: 9450-9456

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Triazole-linked dumbbell oligodeoxynucleotides with NF-kN binding ability as potential decoy molecules.2008

    • Author(s)
      Nakane M.; Ichikawa S.; Matsuda A.
    • Journal Title

      J.Org.Chem. 73

      Pages: 1842-1851

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Repair of CNDAC-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.2008

    • Author(s)
      Y.Wang, X.Liu, A.Matsuda, W.Plunkett
    • Journal Title

      Cancer Res. 68

      Pages: 3881-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Synthesis ans crystal structure of 2'-deoxy-2'-fluoro-4'-thioribonucleosides : substrates for the synthesis of novel modified RNAs.2008

    • Author(s)
      Takahashi M.; Daidouji S.; Shiro M.; Minakawa N.; Matsuda A.
    • Journal Title

      Tetrahedron 64

      Pages: 4313-4324

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Oligonucleotides containing 3-bromo-3-deazaadenine and 7-bromo-7-deazaadenine 2'-deoxynucleosides as chemical probes to investigate DNA-protein interactions.2008

    • Author(s)
      Minakawa N.; Kawano Y.; Murata S.; Inoue N.; Matsuda A.
    • Journal Title

      ChemBioChem. 9

      Pages: 464-470

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Investigations toward the selection of fully-modified 4'-thioRNA aptamers : optimization of in vitro transcription step in the presence of 4'-thioNTPs2008

    • Author(s)
      Minakawa, N. ; Sanji, M. ; Kato, Y. ; Matsuda, A.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 9450-9456

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Inhibition of HIF-1α by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo.2008

    • Author(s)
      H.Yasui, A.Ogura, T.Asanuma, A.Matsuda, I.Kashiwakura, M.Kuwabara, O.Inanami
    • Journal Title

      Br.J.Cancer 99

      Pages: 1442-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Synthesis of Hsp90 inhibitor dimers as potential antitumor agents.2008

    • Author(s)
      K.Muranaka, A.Sano, S.Ichikawa, A.Matsuda
    • Journal Title

      Bioorg.Med.Chem. 16

      Pages: 5862-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Unexpected A-form formation of 4'-thioDNA in solotion, as revealed by NMR, and the implication on the mechanism of nuclease-resistance2008

    • Author(s)
      Matsugami, A. ; Ohyama, T. ; Inada, M. ; Inoue, N. ; Minakawa, N. ; Matsuda, A. ; Katahira, M.
    • Journal Title

      Nucleic Acids Res. 36

      Pages: 1805-1812

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] ATR and DNA-PK cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue2008

    • Author(s)
      X.Liu, A.Matsuda, W.Plunkett
    • Journal Title

      CNDAC.Mol.Cancer Ther 7

      Pages: 133-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Unexpected A-form formation of 4'-thioDNA in solotion, as revealed by NMR, and the implication on the mechanism of nucleaseresistance.2008

    • Author(s)
      Matsugami A.; Ohyama T.; Inada M.; Inoue N.; Minakawa N.; Matsuda A.; Katahira M.
    • Journal Title

      Nucleic Acids Res. 36

      Pages: 1805-1812

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Modular bent DNAs : A new class of artificial DNAs with a protein binding ability.2007

    • Author(s)
      Murata S.; Mizumura Y.; Hino K.; Ueno Y.; Ichikawa S.; Matsuda A.
    • Journal Title

      J.Am.Chem.Soc. 129

      Pages: 10300-10301

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoylmodified uracils reveal the basis for properties as antigene and antisense molecules.2007

    • Author(s)
      Juan E. C. M.; Kondo J.; Kurihara T.; Ito T.; Ueno Y.; Matsuda A.; Takenaka A.
    • Journal Title

      Nucleic Acids Res. 35

      Pages: 1969-1977

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Amplification of 4'-thioDNA in the presence of 4'-thio-Dttp and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells2007

    • Author(s)
      Inoue, N. ; Shionoya, A. ; Minakawa, N. ; Ogawa, N. ; Matsuda, A.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 15424-15425

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Study of modification pattern-RNAi activity relationships using siRNAs modified with 4'-thioribonucleosides, finding an effective modification irrespective of target sequence.2007

    • Author(s)
      Hoshika S.; Minakawa N.; Shionoya A.; Imada K.; Ogawa N.; Matsuda A.
    • Journal Title

      ChemBioChem. 8

      Pages: 2133-2138

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Treatment combining X irradiation and a ribonucleoside anticancer drug, ECyd, synergistically suppresses the growth of tumor cells transplanted in mice.2007

    • Author(s)
      H.Yasui, O.Inanami, T.Asanuma, D.Iizuka, T.Nakajima, Y.Kon, A.Matsuda, M.Kuwabara
    • Journal Title

      Int.J.Rad.Oncol.Biol.Phys. 68

      Pages: 218-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] CNDAG, a potent antitumor agent against B-lymphoma infected with Kaposi's sarcoma- associated Herpesvirus (KSHV).2007

    • Author(s)
      M.Ohtawa, S.Ichikawa, Y.Teishikata, M.Fujimuro, H.Yokosawa, A.Matsuda
    • Journal Title

      J.Med.Chem. 50

      Pages: 2007-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Amplification of 4'-thioDNA in the presence of 4'-thio-dTTP and 4'-thio-dCTP, and 4'-thioDNA-directed transcription in vitro and in mammalian cells.2007

    • Author(s)
      Inoue N.; Shionoya A.; Minakawa N.; Ogawa N.; Matsuda A.
    • Journal Title

      J.Am.Chem. Soc. 129

      Pages: 15424-15425

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Mechanism of action of a new antitumor ribonucleoside, ECyd (TAS-106), differs from that of 5-fluorouracil.2007

    • Author(s)
      H.Kazuno, Y.Shimamoto, H.Tsujimoto, M.Fukushima, A.Matsuda, T.Sasaki
    • Journal Title

      Oncology Rep. 17

      Pages: 1453-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Synthesis and properties of 4'-thioDNA: unexpected RNA-like behavior of 4'-thioDNA.2006

    • Author(s)
      Inoue N.; Minakawa N.; Matsuda A.
    • Journal Title

      Nucleic Acids Res. 34

      Pages: 3476-3483

    • NAID

      120000965196

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine in leuke- mia cell lines.2006

    • Author(s)
      E.Takahashi, O.Inanami, T.Ohta, A.Matsuda, M.Kuwabara
    • Journal Title

      Leuk.Res. 30

      Pages: 1555-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Journal Article] Synthesis and properties of 4'-thioDNA : unexpected RNA-like behavior of 4'-thioDNA2006

    • Author(s)
      Inoue, N. ; Minakawa, N. ; Matsuda, A.
    • Journal Title

      Nucleic Acids Res. 34

      Pages: 3476-3483

    • NAID

      120000965196

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Synthesis and characterization of oligodeoxynucleotides containing naphthyridine : imidazopyridopyrimidine base pairs at their sticky ends. Application as thermally stabilized decoy molecules.2006

    • Author(s)
      Hikishima S.; Minakawa N.; Kuramoto K.; Ogata S.; Matsuda A.
    • Journal Title

      ChemBioChem 7

      Pages: 1970-1975

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Antitumor activity of sugar-modified cytosine nucleosides.2004

    • Author(s)
      Matsuda, A., et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 105-111

    • NAID

      10012710063

    • Data Source
      KAKENHI-PROJECT-12217001
  • [Patent] オリゴヌクレオチド誘導体、並びにオリゴヌクレオチド誘導体を含む治療用医薬組成物及び診断用医薬組成物2011

    • Inventor(s)
      松田彰, 高橋真由美
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2011-125734
    • Filing Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Patent] 新規ピロロカルバゾールジオン化合物又はその塩2008

    • Inventor(s)
      市川 聡, 佐古友希, 佐野亜希子, 松田 彰
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社、北海道大学
    • Industrial Property Number
      2008-276771
    • Filing Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Patent] 新規プリンダイマー化合物またはその塩,およびその用途2007

    • Inventor(s)
      村中一大, 市川 聡, 松田 彰, 佐野亜希子
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社、北海道大学
    • Industrial Property Number
      2007-279056
    • Filing Date
      2007-10-26
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Patent] shRNA発現用DNAカセット2007

    • Inventor(s)
      松田彰,南川典昭,塩野谷亜紀,尾川直樹
    • Industrial Property Rights Holder
      北海道大学
    • Filing Date
      2007-11-16
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Patent] shRNA 発現用DNA カセット2007

    • Inventor(s)
      松田彰, 南川典昭, 塩野谷亜紀, 尾川直樹
    • Industrial Property Number
      2007-298097
    • Filing Date
      2007-11-16
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Patent] 4'-セレノヌクレオシド及び4'-セレノヌクレオチド2007

    • Inventor(s)
      松田彰, 南川典昭, 稲垣勇典
    • Industrial Property Number
      2007-032111
    • Filing Date
      2007-02-13
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Patent] shRNA発現用DNAカセット2007

    • Inventor(s)
      松田 彰
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Number
      2007-298097
    • Filing Date
      2007-11-16
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸医薬の組織標的化2015

    • Author(s)
      松田 彰
    • Organizer
      抗体医薬・核酸医薬開発コンソーシアムシンポジウム(医薬基盤研)
    • Place of Presentation
      コクヨホール・東京
    • Year and Date
      2015-01-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] 四本の水素結合対を持つ塩基対の酵素的取込みー第三の塩基対創出を目指してー2015

    • Author(s)
      松田 彰
    • Organizer
      日本薬学会第135年会、一般シンポジウム「アカデミア創薬に向けた核酸化学の新たな取り組み」
    • Place of Presentation
      神戸学院大学・兵庫
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] バイオ創薬のススメ2014

    • Author(s)
      松田 彰
    • Organizer
      理研シンポジウム、第9回有機合成化学のフロンティア
    • Place of Presentation
      理化学研究所、埼玉
    • Year and Date
      2014-06-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] 核酸医薬の組織標的化2014

    • Author(s)
      松田 彰
    • Organizer
      アンチセンスDNA/RNA研究会・特別シンポジウム「核酸医薬の過去・現在・未来」
    • Place of Presentation
      東京ガーデンパレス・東京
    • Year and Date
      2014-09-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] ヌクレアーゼ抵抗性4'-チオ核酸誘導体を用いる核酸医薬の創製を目指して2011

    • Author(s)
      松田彰
    • Organizer
      第6回分子複合医薬研究会
    • Place of Presentation
      産業技術総合研究所関西センター(大阪府)(招待講演)
    • Year and Date
      2011-05-23
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] 核酸創薬の最前線2010

    • Author(s)
      松田彰
    • Organizer
      第26回創薬セミナー
    • Place of Presentation
      八ヶ岳ロイヤルホテル 招待講演
    • Year and Date
      2010-07-29
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸創薬の最前線2010

    • Author(s)
      松田彰
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      甲南大学ポートアイランドキャンパス(神戸) 招待講演
    • Year and Date
      2010-12-02
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸創薬2009

    • Author(s)
      松田彰
    • Organizer
      第28回メデシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸創薬2009

    • Author(s)
      松田彰
    • Organizer
      第28回メデシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-17016001
  • [Presentation] 核酸化学からアプタマーへ : ヌクレアーゼ抵抗性の化学的調節2008

    • Author(s)
      松田 彰、加藤優佳、三次未央子、高橋真由美、南川典昭
    • Organizer
      第18回日本サイトメトリー学会「サイトメトリーシステムの未来を考える(1)アプタマーは抗体を越えるのか?
    • Place of Presentation
      東京慈恵医科大学
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸化学からアプタマーヘ : ヌクレアーゼ抵抗性の化学的調節2008

    • Author(s)
      松田彰
    • Organizer
      第18回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京慈恵会医科大学
    • Year and Date
      2008-06-29
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 核酸化学から創薬へ先端融合領域イノベーション創出拠点形成「未来創薬・医療イノベーション拠点形成」事業2007

    • Author(s)
      松田 彰
    • Organizer
      第3回未来創薬・医療イノベーションシンポジウムー未来創薬から医療への架け橋
    • Place of Presentation
      北海道大学
    • Year and Date
      2007-06-27
    • Data Source
      KAKENHI-PROJECT-18109001
  • [Presentation] 2’-O-Me-4’-thioRNA as a Potential Use for Oligonucleotide Therapeutics

    • Author(s)
      Akira Matsuda
    • Organizer
      8th Annual Meeting of the Oligonucleotide therapeutics Society
    • Place of Presentation
      The Conference Center at the Harvard Medical School(USA)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] Development of Sugar-modified Cytosine Nucleosides as Antitumor Agents,Old Stories for Future Success

    • Author(s)
      Akira Matsuda
    • Organizer
      20th International Roundtable for Nucleosides, Nucleotides & Nucleic Acids
    • Place of Presentation
      McGill University(Canada)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] バイオ創薬のすすめ

    • Author(s)
      松田 彰
    • Organizer
      第3回CSJ化学フェスタ2013
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] バイオ創薬のすすめ

    • Author(s)
      松田 彰
    • Organizer
      創薬懇話会2013
    • Place of Presentation
      定山渓ビューホテル(札幌市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • [Presentation] バイオ創薬のススメ

    • Author(s)
      松田 彰
    • Organizer
      第32回白金シンポジウム-創薬研究の最前線-
    • Place of Presentation
      北里大学薬学部コンベンションホール(東京都港区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249008
  • 1.  WATAYA Yusuke (90127598)
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 79.  上野 義仁 (20250467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 80.  早津 彦哉 (10012593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 81.  WATANABE Tohru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 82.  SUZUKI Yousuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 83.  安田 新
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 84.  福川 清史
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 85.  FUKUKAWA Kiyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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