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YOKOTA Takanori  横田 隆徳

ORCIDConnect your ORCID iD *help
… Alternative Names

横田 隆徳  ヨコタ タカノリ

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Researcher Number 90231688
Other IDs
External Links
Affiliation (Current) 2025: 東京科学大学, 大学院医歯学総合研究科, 教授
Affiliation (based on the past Project Information) *help 2016 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2013 – 2016: 東京医科歯科大学, 医歯学総合研究科, 教授
2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授
2012: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 … More
2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 特別研究教授
2009 – 2012: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授
2011: 東京医科歯科大学, 大学院・医歯学総合研究科脳神経病態学, 教授
2007 – 2008: Tokyo Medical and Dental University, Dept Neural, Associate Professor
2006: 東京医科歯科大学, 大学院医歯学総合研究科, 助教授
2004 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教授
2002 – 2003: TOKYO MEDICAL AND DENTAL UNIVERSITY, DEPARTMENT OF NEUROLOGY AND NEUROLOGICAL SCIENCE, ASSISTANT PROFESSOR, 医学部附属病院, 講師
2001: 東京医科歯科大学, 医学部・附属病院, 講師
2001: 東京医科歯科大学, 医学部・附属病院科, 講師
2000: Tokyo Medical and Dental University, Faculty of Medicine, Lecturer, 医学部, 講師
2000: 東京医科歯科大学, 医学部・付属病院, 講師
1995 – 1999: 東京医科歯科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Gastroenterology / Neurology / Biomedical engineering/Biomaterial science and engineering / Ophthalmology / Biological Sciences / Nerve anatomy/Neuropathology / Neurology / Biological Sciences / Neurochemistry/Neuropharmacology / Laboratory animal science … More
Except Principal Investigator
… More Neurology / Neurology / Neurochemistry/Neuropharmacology / Medium-sized Section 51:Brain sciences and related fields / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 90130:Medical systems-related / Medium-sized Section 52:General internal medicine and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Neurochemistry/Neuropharmacology / Chemistry / Science and Engineering / Biomedical engineering/Biomaterial science and engineering / Laboratory animal science Less
Keywords
Principal Investigator
siRNA / GBV-B / RNA干渉 / ビタミンE / 核酸医薬 / ALS / AAV / shRNA / SOD1 / RNAi … More / 核酸 / marmoset / RNA interference / インターフェロン / タマリン / C型肝炎 / カチオニックベクター / RT-PCR / TDP-43 / 筋萎縮性側索硬化症 / 神経変性疾患 / 脳梗塞 / コレステロール / 遺伝子治療 / デリバリー / αTTP / アルツハイマー病 / バイオテクノロジー / Glut / Glut 1/4 / トランスフェリン / リサイクリング / Glucose transporter / トランスフェリンレセプター / LDL受容体 / ヘテロ核酸 / 抗体工学 / トランスフェリン受容体 / グルコーストランスポーター / 血液脳関門 / 2本鎖核酸医薬 / アンチセンス核酸医薬 / Vitamin E / Tamarin / AAV8 / 新世界ザル / マンモセット / interferon / tamarin / Hepatitis C / cationic vector / HCV / インテーフェロン / マーモセット / virus vector / catalyticDNA / ribozyme / Gene therapy / SOD / G93Aトランスジェニックマウス / アデノウイルスベクター / カタリテックDNA / SODI / DNAエンザイム / ウイルスベクター / カタリチックDNA / リボザイム / Purkinje cell / posterior column / Bergmann glia / spinocerebellar degeneration / retinitis pigmentosa / vitamin E / knockout mouse / α-tocopherol / 脊髄小脳変異症 / Friedriech失調症 / α-トコフェロール / プルキンエ細胞 / 後索 / バーグマングリア / 脊髄小脳変性症 / 網膜色素変性症 / ノックアウトマウス / アルファトコフェロール / exon skipping / microRNA阻害薬 / microRNA / ホスホロチオエート結合修飾 / PNA / ELISA / 後根神経節細胞 / アンチセンス / 医薬分子設計 / 皮膚 / SHSY-5Y / リン酸化ニューロフィラメンド / 外側核 / サルモデル / Cystatin C / 運動ニューロン / Betz巨細胞 / リン酸化 / 前角運動神経細胞 / サル / エクソソーム / 軸索電流 / 動物モデル / 多発性硬化症 / 脳血管内皮細胞 / 脳血管関門 / グリア細胞 / 脳神経細胞 / Dicer / HDL / BACE1 / ->マウス / TTPa^<- / Aβ産生 / Aβ重合 / Aβ排泄 / Aβ / 脂質過酸化 / キメラマウス / ES細胞 / トランスジェニックマウス / サブトラクションcDNAライブラリー / pCMV発現ベクター / taggingベクター / mutationベクター / 2段階標的遺伝子組換法 / 運動ニューロン単位 / エレクトロポレーション / neural plasticity / PC12 / CMVベクター / pRc / アンドロゲンレセプター / CAGリピート … More
Except Principal Investigator
SOD1 / 遺伝子治療 / SCA6 / siRNA / αTTP / 脊髄小脳変性症 / 動物モデル / 核酸医薬 / ALS / RNAi / 血液脳関門 / P / aTTP / CACNA1A / Caチャンネル / プルキンエ細胞 / ヘテロ核酸 / 筋萎縮性側索硬化症 / TDP-43 / 酸化ストレス / アルツハイマー病 / AAV / トランスジェニックマウス / ビタミンE / ポリグルタミン病 / 神経変性疾患 / 歯状核赤核淡蒼球ルイ体萎縮症 / pseudo-fasting / 腸脳連関 / グルコース / 特殊飼料 / FDG-PET / Glucose transporter-1 / 脳血管内皮細胞 / pseudo-fasting状態 / 神経超音波 / 生体磁場計測装置 / 末梢神経 / 生体磁場計測 / 抗体 / グルコース輸送体 / MRI / 脳エネルギー代謝 / スキッピング / カヘキシア / エクソン・スキッピング / 筋疾患 / 脂質リガンド / 遺伝性筋疾患 / 骨格筋 / 心筋 / splicing / neurodegeneration / gene therapy / Q type calcium channel / polyglutamine disease / 培養細胞 / 脊髄小脳変性症6型 / スプライス / 神経変性 / Q型カルシウムチャネル / 脊髓小脳変性症 / lipid peroxidation / Oxidative stress / ALS. / vitamin E. / G93A トランスジェニックマウス / 運動ニューロン / α-tocopherol / SOD / aTTP KOマウス / G93Aトランスジェニックマウス / 運動ニューロン疾患 / 脂質酸化 / S0D1 / ANIMAL MODEL / PURKINJE CELL / CA CHANNEL / CAG REPEAT / SPINOCEREBELLAR DEGENERATION / CACNAIA / ES細胞 / 脊髄小脳変形症 / CACN1A / ノックインマウス / CAGピート / CAGリピート / hereditary ataxias / knock out / vitamin E deficiency / alpha-tocopherol transfer protein / 遺伝性矢調症 / ノックアウトマウス / ビタミンE欠乏 / ビタミンE転移蛋白 / グルコーストランスポ-ター / 脳―血液関門 / 脳一血液関門 / グルコーストランスポーター / 脳-血液関門 / 抗体医薬 / プラスミドDNA / メッセンジャーRNA / アンチセンス核酸 / 血液脳関門(BBB) / 薬物送達システム / ポリアミノ酸 / ポリエチレングリコール / 高分子ミセル / ブロック共重合体 / pH / 脳梗塞 / 刺激応答性核酸 / 脳神経疾患 / 神経科学 / 虚血応答性核酸 / 脳血管障害 / 血管新生 / 水素イオン指数 / 環境応答型核酸 / 人工核酸 / マウス / 神経保護 / 脳卒中 / 伝播 / ラット / ラットモデル / 筋萎縮性側索硬化症(ALS) / LRP-1 / クリアランス / 排泄 / アミロイドベータ / FAP / shRNA毒性 / モデルマウス / shRNA / 小脳 / RNA毒性 / PKR / Machado-Joseph病 Less
  • Research Projects

    (34 results)
  • Research Products

    (372 results)
  • Co-Researchers

    (58 People)
  •  生体磁場計測装置を用いた末梢神経活動電流の可視化

    • Principal Investigator
      赤座 実穂
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90130:Medical systems-related
    • Research Institution
      Tokyo Medical and Dental University
  •  脳への糖輸送機構を解明し、高分子医薬品を脳へ送達させる基盤技術を実用化する研究

    • Principal Investigator
      西田 陽一郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Joint international project to establish antisense oligonucleotide therapy for treating Dentatorubral-Pallidoluysian Atrophy (DRPLA)

    • Principal Investigator
      中山 東城
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 51:Brain sciences and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of blood-brain barrier-crossing antibodies utilizing the biological features of glucose transporters

    • Principal Investigator
      平田 浩聖
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of innovative nucleic acid therapy enabling any gene control in cardiac and skeletal muscle

    • Principal Investigator
      Nagata Tetsuya
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of heteroduplex oligonucleotide crossing the blood-brain barrierPrincipal Investigator

    • Principal Investigator
      Yokota Takanori
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of therapeutic oligonucleotides without ligand conjugation.Principal Investigator

    • Principal Investigator
      Yokota Takanori
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of Ischemia-Specific Oligonucleotide Therapeutics System for Acute stroke

    • Principal Investigator
      ISHIBASHI SATORU
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of a new type of microRNA inhibitorPrincipal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

    • Principal Investigator
      KATAOKA Kazunori
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Science and Engineering
      Chemistry
    • Research Institution
      Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
      The University of Tokyo
  •  Development of novel triple-stranded antisense oligonucleotidesPrincipal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of rat model of TDP-43 propagation

    • Principal Investigator
      KANOUCHI Tadashi
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  ALSサルモデル、患者サンプルを用いたTDP―43病態の検索Principal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of primate model of sporadic ALS with overexpression of TDP-43Principal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment for rat model of sporadic amyotrophic lateral sclerosis

    • Principal Investigator
      OHKUBO Takuya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  内因性ベクターを用いた中枢神経系への新規siRNAデリバリー方法の開発Principal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  アルツハイマー病の脳からのAΒ排泄障害はAΒ全身クリアランスの障害と関連する

    • Principal Investigator
      冨満 弘之
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Medical and Dental University
  •  血液脳関門への新規siRNAデリバリー法の開発Principal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  あらゆる遺伝子を標的にできるsiRNAトランスジェニックマウスの新規作製方法

    • Principal Investigator
      叶内 匡
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokyo Medical and Dental University
  •  新規siRNAデザインによるサルを用いた家族性アミロイドポリニューロパチーの治療

    • Principal Investigator
      久保寺 隆行
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  脂質酸化はAベータの脳からの排泄を低下させるPrincipal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Medical and Dental University
  •  ビタミンEを用いたsiRNAの脳への新しいデリバリー法の開発

    • Principal Investigator
      KANOUCHI Tadashi
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Medical and Dental University
  •  いかなる変異に対しても特異的な新規RNA干渉法のin vivoでの有効性の検討

    • Principal Investigator
      久保寺 隆行
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Gene therapy of Hepatitis C using monkey by siRNAPrincipal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Tokyo Medical and Dental University
  •  ポリグルタミン病のCAGリピートは2本鎖様なって毒性をもつ

    • Principal Investigator
      久保寺 隆行
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Elucidation of pathomechanism and development of treatment of spinocerebellar ataxia type 6

    • Principal Investigator
      MIZUSAWA Hidehiro
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  ES細胞を用いたsiRNAによる新しいノックダウンマウス作製法の開発Principal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Tokyo Medical and Dental University
  •  Gene therapy of Hepatitis C using monkey by siRNAPrincipal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Department of Neurology and Neurological Science, Tokyo medicak and Dental University
  •  Gene Therapy for ALS with mutant SOD1 by ribozyme and catalytic DNA.Principal Investigator

    • Principal Investigator
      YOKOTA Takanori
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Pathophysiology of amyotrophic lateral ]sclerosi using aipha-tocopherol transfer protein gene knockout mouse.

    • Principal Investigator
      INABA Akira
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Medical and Dental University
  •  STUDIES ON MOLECULAR AND CLINICAL PATHOMECHANISM OF SPINOCEREBELLAR DEGENERATION

    • Principal Investigator
      MIZUSAWA Hidehiro
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Pathophysiology of spinocerebellar degeneration /retinitis pigmentosa linked to a point mutation of alpha-tocopherol transfer protein gene

    • Principal Investigator
      UCHIHARA Toshiki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Institute for Neuroscience
      Tokyo Metropolitan Institute for Neuroscience
  •  Research for transgenic mouse of retinitis pigmentosa with vitamin E deficiencyPrincipal Investigator

    • Principal Investigator
      INABA Akira, 横田 隆徳
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Tokyo Medical and Dental University
  •  Kennedy-Alter-Sung症候群の病態モデルの構築Principal Investigator

    • Principal Investigator
      横田 隆徳
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University

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All Journal Article Presentation Book Patent

  • [Book] 神経筋疾患のRNAi治療の展望. Annual Review2011神経2011

    • Author(s)
      久保寺隆行, 仁科一隆, 横田隆徳
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Book] RNAiの神経疾患への応用. RNA工学の基礎と応用2011

    • Author(s)
      横田隆徳, 仁科一隆
    • Publisher
      シーエムシー出 版
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Book] 神経筋疾患のRNAi治療の展望 Annual Review 2011神経2011

    • Author(s)
      久保寺隆行, 仁科一隆, 横田隆徳
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Book] RNAiの神経疾患への応用。RNA工学の基礎と応用2011

    • Author(s)
      横田隆徳、仁科一隆
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Book] 神経変性疾患のサイエンス2007

    • Author(s)
      横田隆徳
    • Publisher
      南山堂(印刷中)
    • Data Source
      KAKENHI-PROJECT-18650103
  • [Book] RNAiを用いた神経変性疾愚への臨床応用。「神経変性疾患のサイエンス」2007

    • Author(s)
      横田隆徳:高橋良輔編
    • Total Pages
      10
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Book] RNAi therapeutics.2007

    • Author(s)
      Yokota T.
    • Total Pages
      10
    • Publisher
      Transworld Research Network
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Book] In delivery and therapeutics of siRNA2007

    • Author(s)
      Yokota T
    • Publisher
      Elsevier(In press)
    • Data Source
      KAKENHI-PROJECT-18659256
  • [Book] 神経変性疾患のサイエンス2007

    • Author(s)
      横田隆徳
    • Publisher
      南山堂(印刷中)
    • Data Source
      KAKENHI-PROJECT-18659256
  • [Book] siRNA-based gene therapy for autosomal dominant disease of the nervous system. In RNAi therapeutics.2007

    • Author(s)
      Yokota T. Ed by Takaku H, Yamamoto N.
    • Total Pages
      5
    • Publisher
      Transworld Research Network
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Book] In delivery and therapeutics of siRNA2007

    • Author(s)
      Yokota T
    • Publisher
      Elsevier(In press)
    • Data Source
      KAKENHI-PROJECT-18650103
  • [Book] RNA工学の最前線2005

    • Author(s)
      横田隆徳, 仁科一隆
    • Publisher
      RNAiの神経疾患への応用
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Book] RNA工学の最前線2005

    • Author(s)
      横田隆徳
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Book] In Non-viral Gene Therapy2005

    • Author(s)
      Yokota T
    • Total Pages
      12
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-17659260
  • [Book] RNA工学の最前線2005

    • Author(s)
      横田隆徳
    • Total Pages
      11
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-17659260
  • [Book] Non-viral gene therapy : Gene design and delivery.2005

    • Author(s)
      Yokota T
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Book] RNA工学の最前線(中村義一, 大内将司, 編集)2005

    • Author(s)
      横田隆徳, 仁科一隆
    • Total Pages
      11
    • Publisher
      シーエムシー出版
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Book] In Non-viral Gene Therapy2005

    • Author(s)
      Yokota T
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Book] 神経内科の最新医療2004

    • Author(s)
      横田隆徳, 水澤英洋
    • Publisher
      先端医療技術研究
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain2023

    • Author(s)
      Amano A, Sanjo N, Araki W, Anraku Y, Nakakido M, Matsubara E, Tomiyama T, Nagata T, Tsumoto K, Kataoka K, Yokota T.
    • Journal Title

      J Nanobiotechnology

      Volume: 21 Issue: 1 Pages: 36-50

    • DOI

      10.1186/s12951-023-01772-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19510, KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-20K07798
  • [Journal Article] Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients2023

    • Author(s)
      Ohara Masahiro、Hirata Kosei、Hallett Mark、Matsubayashi Taiki、Chen Qingmeng、Kina Satoko、Shimano Kaoru、Hirakawa Akihiro、Yokota Takanori、Hattori Takaaki
    • Journal Title

      Parkinsonism &amp; Related Disorders

      Volume: 108 Pages: 105322-105322

    • DOI

      10.1016/j.parkreldis.2023.105322

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Journal Article] Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease2023

    • Author(s)
      Hirata Kosei、Matsuoka Kiwamu、Tagai Kenji、Endo Hironobu、Tatebe Harutsugu、Ono Maiko、Kokubo Naomi、Oyama Asaka、Shinotoh Hitoshi、Takahata Keisuke、Obata Takayuki、Dehghani Masoumeh、Near Jamie、Kawamura Kazunori、Zhang Ming‐Rong、Shimada Hitoshi、Yokota Takanori、Tokuda Takahiko、Higuchi Makoto、Takado Yuhei
    • Journal Title

      Annals of Neurology

      Volume: 95 Issue: 1 Pages: 104-115

    • DOI

      10.1002/ana.26797

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268, KAKENHI-PROJECT-22K07529, KAKENHI-PROJECT-22K19393
  • [Journal Article] Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides2022

    • Author(s)
      Nishi Rieko、Ohyagi Masaki、Nagata Tetsuya、Mabuchi Yo、Yokota Takanori
    • Journal Title

      Molecular Therapy

      Volume: 30 Issue: 6 Pages: 2210-2223

    • DOI

      10.1016/j.ymthe.2022.02.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-17H06109
  • [Journal Article] Serial ultrathin sections to identify ultrastructural localization of GLUT1 molecules in vesicles in brain endothelial cells-correlative light and electron microscopy in depth.2022

    • Author(s)
      Yamada A, Nishida Y, Wake K, Nakamura A, Sakamaki Y, Kuwahara H, Uchihara T, Yokota T
    • Journal Title

      Microscopy (Oxf)

      Volume: 71 Issue: 2 Pages: 124-131

    • DOI

      10.1093/jmicro/dfac005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-17H06109
  • [Journal Article] Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage2022

    • Author(s)
      Chen Qingmeng、Hattori Takaaki、Tomisato Hiroshi、Ohara Masahiro、Hirata Kosei、Yokota Takanori、for the Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      Human Brain Mapping

      Volume: 44 Issue: 3 Pages: 1193-1208

    • DOI

      10.1002/hbm.26151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Journal Article] Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In?Vivo2021

    • Author(s)
      Asami Yutaro、Nagata Tetsuya、Yoshioka Kotaro、Kunieda Taiki、Yoshida-Tanaka Kie、Bennett C. Frank、Seth Punit P.、Yokota Takanori
    • Journal Title

      Molecular Therapy

      Volume: 29 Issue: 2 Pages: 838-847

    • DOI

      10.1016/j.ymthe.2020.10.017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine)2021

    • Author(s)
      Naito Mitsuru、Chaya Hiroyuki、Toh Kazuko、Kim Beob Soo、Hayashi Kotaro、Fukushima Shigeto、Nagata Tetsuya、Yokota Takanori、Kataoka Kazunori、Miyata Kanjiro
    • Journal Title

      Journal of Controlled Release

      Volume: 330 Pages: 812-820

    • DOI

      10.1016/j.jconrel.2021.01.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K18379, KAKENHI-PROJECT-19H01016
  • [Journal Article] Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking2021

    • Author(s)
      Ono Daisuke、Asada Ken、Yui Daishi、Sakaue Fumika、Yoshioka Kotaro、Nagata Tetsuya、Yokota Takanori
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 23 Pages: 1360-1370

    • DOI

      10.1016/j.omtn.2020.11.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05550, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo2021

    • Author(s)
      Ohyagi Masaki、Nagata Tetsuya、Ihara Kensuke、Yoshida-Tanaka Kie、Nishi Rieko、Miyata Haruka、Abe Aya、Mabuchi Yo、Akazawa Chihiro、Yokota Takanori
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 7344-7344

    • DOI

      10.1038/s41467-021-26902-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing2021

    • Author(s)
      Asada Ken、Sakaue Fumika、Nagata Tetsuya、Zhang Ji-chun、Yoshida-Tanaka Kie、Abe Aya、Nawa Makiko、Nishina Kazutaka、Yokota Takanori
    • Journal Title

      Nucleic Acids Research

      Volume: 49 Issue: 9 Pages: 4864-4876

    • DOI

      10.1093/nar/gkab258

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01016
  • [Journal Article] Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol?conjugated heteroduplex oligonucleotide in mice2021

    • Author(s)
      Suzuki Motohiro、Ishibashi Satoru、Iwasawa Eri、Oguma Takahiro、Saito Yasuhiro、Li Fuying、Otsu Shinichi、Ichinose Keiko、Yoshioka Kotaro、Nagata Tetsuya、Yokota Takanori
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 14237-14237

    • DOI

      10.1038/s41598-021-93666-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07733, KAKENHI-PROJECT-20K09366, KAKENHI-PROJECT-19H01016
  • [Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021

    • Author(s)
      Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T
    • Journal Title

      Nat Biotechnol

      Volume: 39 Issue: 12 Pages: 1529-1536

    • DOI

      10.1038/s41587-021-00972-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface2019

    • Author(s)
      Yamashita Takefumi、Mizohata Eiichi、Nagatoishi Satoru、Watanabe Takahiro、Nakakido Makoto、Iwanari Hiroko、Mochizuki Yasuhiro、Nakayama Taisuke、Kado Yuji、Yokota Yuki、Matsumura Hiroyoshi、Kawamura Takeshi、Kodama Tatsuhiko、Hamakubo Takao、Inoue Tsuyoshi、Fujitani Hideaki、Tsumoto Kouhei
    • Journal Title

      Structure

      Volume: 27 Issue: 3 Pages: 519-527

    • DOI

      10.1016/j.str.2018.11.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06094, KAKENHI-PUBLICLY-17H05732, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-17H06109
  • [Journal Article] Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo.2018

    • Author(s)
      H. Kuwahara, J. Song, T. Shimoura, K. Yoshida-Tanaka, T. Mizuno, T. Mochizuki, S. Zeniya, F. Li, K. Nishina, T. Nagata, S. Ito, H. Kusuhara, T. Yokota
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 4-377

    • DOI

      10.1038/s41598-018-22577-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain2017

    • Author(s)
      Anraku Y.、Kuwahara H.、Fukusato Y.、Mizoguchi A.、Ishii T.、Nitta K.、Matsumoto Y.、Toh K.、Miyata K.、Uchida S.、Nishina K.、Osada K.、Itaka K.、Nishiyama N.、Mizusawa H.、Yamasoba T.、Yokota T.、Kataoka K.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 2001-2009

    • DOI

      10.1038/s41467-017-00952-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-15H04813, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H04742, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-15K20962, KAKENHI-PROJECT-25000006
  • [Journal Article] Depressive disorder may be associated with raphe nuclei lesions in patients with brainstem infarction.2017

    • Author(s)
      Numasawa Y, Hattori T, Ishiai S, Kobayashi Z, Kamata T, Kotera M, Ishibashi S, Sanjo N, Mizusawa H, Yokota T
    • Journal Title

      J Affect Disord.

      Volume: 213 Pages: 191-198

    • DOI

      10.1016/j.jad.2017.02.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-23500596, KAKENHI-PROJECT-17H01548
  • [Journal Article] Acute development of collateral circulation and therapeutic prospects in ischemic stroke.2016

    • Author(s)
      Iwasawa E, Ichijo M, Ishibashi S, Yokota T.
    • Journal Title

      Neural Regen Res.

      Volume: 11 Issue: 3 Pages: 368-71

    • DOI

      10.4103/1673-5374.179033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Journal Article] Gene therapy with therapeutic oligonucleotides2016

    • Author(s)
      横田隆徳、仁科一隆、桑原宏哉
    • Journal Title

      Neurological Therapeutics

      Volume: 33 Issue: 3 Pages: 303-306

    • DOI

      10.15082/jsnt.33.3_303

    • NAID

      130005279080

    • ISSN
      0916-8443, 2189-7824
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Journal Article] Progressive Multifocal Leukoencephalopathy with Balanced CD4/CD8 T-Cell Infiltration and Good Response to Mefloquine Treatment2016

    • Author(s)
      Sanjo N, Kina S, Shishido-Hara Y, Nose Y, Ishibashi S, Fukuda T, Maehara K, Eishi Y, Mizusawa H, Yokota T
    • Journal Title

      Intern. Med.

      Volume: 55 Issue: 12 Pages: 1631-1635

    • DOI

      10.2169/internalmedicine.55.6051

    • NAID

      130005157669

    • ISSN
      0918-2918, 1349-7235
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15K06759
  • [Journal Article] Blood-brain barrier : a novel therapeutic target in multiple sclerosis.2015

    • Author(s)
      H. Kuwahara, K. Nishina, T. Yokota
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 6 Issue: 2 Pages: 129-138

    • DOI

      10.1111/cen3.12212

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Journal Article] DNA/RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing.2015

    • Author(s)
      Nishina K., Piao W., Yoshida-Tanaka K., Sujino Y., Nishina T., Yamamoto T., Nitta K, Yoshioka K, Kuwahara H., Yasuhara H., Baba T., Ono F., Miyata K, Miyake K., P. Seth P., Low A., Yoshida M., Bennett C.F., Kataoka K., Mizusawa H., Obika S. Yokota T.
    • Journal Title

      Nature Commun.

      Volume: 6 Issue: 1 Pages: 7969-7969

    • DOI

      10.1038/ncomms8969

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25000006
  • [Journal Article] Chimeric Antisense Oligonucleotide Conjugated to α- Tocopherol2015

    • Author(s)
      Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 4 Pages: e220-e220

    • DOI

      10.1038/mtna.2014.72

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
  • [Journal Article] A Score for Predicting Paroxysmal Atrial Fibrillation in Acute Stroke Patients: iPAB Score2015

    • Author(s)
      Yoshioka K, Watanabe K, Zeniya S, Ito Y, Hizume M, Kanazawa T, Tomita M, Ishibashi S, Miake H, Tanaka H, Yokota T, Mizusawa H
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Issue: 10 Pages: 2263-9

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.06.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Journal Article] Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells2015

    • Author(s)
      Iwata R, Nakayama F, Hirochi S, Sato K, Piao W, Nishina K, Yokota T, Wada T
    • Journal Title

      Bioorg Med Chem. Lett

      Volume: 25 Issue: 4 Pages: 815-819

    • DOI

      10.1016/j.bmcl.2014.12.079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
  • [Journal Article] Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke.2015

    • Author(s)
      Ichijo M, Ishibashi S, Li F, Yui D, Miki K, Mizusawa H, Yokota T.
    • Journal Title

      PLoS One.

      Volume: 14 Issue: 10 Pages: 1839-45

    • DOI

      10.3174/ajnr.a4384

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Journal Article] Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme2015

    • Author(s)
      Yui D, Nishida Y, Nishina T, Mogushi K, Tajiri M, Ishibashi S, Ajioka I, Ishikawa K, Mizusawa H, Murayama S, Yokota T
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 12 Pages: e0143518-e0143518

    • DOI

      10.1371/journal.pone.0143518

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Journal Article] Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E2014

    • Author(s)
      Rintaro Iwata, Kazutaka Nishina, Takanori Yokota, Takeshi Wada
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 4 Pages: 1394-1403

    • DOI

      10.1016/j.bmc.2013.12.060

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-26282136
  • [Journal Article] Elevated platelet microparticle levels after acute ischemic stroke with concurrent idiopathic thrombocytopenic purpura2014

    • Author(s)
      Ichijo M, Ishibashi S, Ohkubo T, Nomura S, Sanjo N, Yokota T, Mizusawa H
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 23 Issue: 3 Pages: 587-9

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.04.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Journal Article] Intrathecal AAV Serotype 9-mediated Delivery of shRNA Against TRPV1 Attenuates Thermal Hyperalgesia in a Mouse Model of Peripheral Nerve Injury.2014

    • Author(s)
      Hirai T, Enomoto M, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M, Kuwahara H, Yamamoto M, Tajiri M, Miyata H, Hirai Y, Tominaga M, Shinomiya K, Mizusawa H, Okawa A, Yokota T
    • Journal Title

      Mol Ther

      Volume: 22 Issue: 2 Pages: 409-19

    • DOI

      10.1038/mt.2013.247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592188, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26282136
  • [Journal Article] Short interfering RNA and the central nervous system: development of nonviral delivery systems2013

    • Author(s)
      Kazutaka Nishina, Hidehiro Mizusawa, Takanori Yokota
    • Journal Title

      Expert Opin Drug Deliv

      Volume: vol.10,No.3 Issue: 3 Pages: 289-292

    • DOI

      10.1517/17425247.2013.748746

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659044, KAKENHI-PROJECT-24659258
  • [Journal Article] Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice.2012

    • Author(s)
      Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, Hirai Y, Sotome S, Mizusawa H, Shinomiya K, Okawa A, Yokota T.
    • Journal Title

      Hum Gene Ther Methods

      Volume: 23 Issue: 2 Pages: 119-27

    • DOI

      10.1089/hgtb.2012.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592188, KAKENHI-PROJECT-24659044
  • [Journal Article] Canregional spreading of ALS motor symptoms be explained by prion-like propagation2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Can regional spreading of ALS motor symptoms be explained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Non-human primate model of ALS with cytoplasmic mislocalizaion of TDP-43. Brain2012

    • Author(s)
      Uchida A, Sasaguri H, Kimura N, TajiriM, Ono F, Ohkubo T, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Ueno T, Yamamoto M, Kubodera T, Tomori M, Sakaki K, Enomoto M, HiraiY, Yasutomi Y, Mochizuki H, Uchihara T, Kuwabara S, Mizusawa H, Yokota T.
    • Volume
      135
    • Pages
      833-46
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-432012

    • Author(s)
      Uchida A, Sasaguri H, Enomoto M, (18番目), et al
    • Journal Title

      Brain

      Volume: 135 Issue: 3 Pages: 833-46

    • DOI

      10.1093/brain/awr348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591894, KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22500325, KAKENHI-PROJECT-22890051, KAKENHI-PUBLICLY-23110505, KAKENHI-PROJECT-23591269, KAKENHI-PROJECT-23591753
  • [Journal Article] Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Pages: 739-45

    • Data Source
      KAKENHI-PROJECT-24659425
  • [Journal Article] Can regional spreading of amyotrophic lateral sclerosis motor symptoms beexplained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: vol. 83, No. 7 Issue: 7 Pages: 739-745

    • DOI

      10.1136/jnnp-2011-301826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-24659425, KAKENHI-PROJECT-24689039
  • [Journal Article] Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein2011

    • Author(s)
      Kuwahara H, Nishina K, Yoshida K, Nishina T, Yamamoto M, Saito Y, Piao W, Yoshida M, Mizusawa H, Yokota T
    • Journal Title

      Mol Ther

      Volume: 19 Issue: 12 Pages: 2213-2221

    • DOI

      10.1038/mt.2011.186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039, KAKENHI-PUBLICLY-23110505
  • [Journal Article] Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles2011

    • Author(s)
      Mayra A, Tomimitsu H, Kubodera T, Kobayashi M, Piao W, Sunaga F, Hirai Y, Shimada T, Mizusawa H, Yokota T
    • Journal Title

      Biochemical and Biophysical Research

      Volume: 405 Pages: 204-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] In Vivo application of an RNAi strategy for the Selective Suppression of a Mutant Allele2011

    • Author(s)
      Kubodera T, Yamada H, Anzai M, Ohira S, Yokota S, Hirai Y, Mochizuki H, Shimada T, Mitani T, Mizusawa H, Yokota T
    • Journal Title

      Hum Gene Ther

      Volume: 22 Issue: 1 Pages: 27-34

    • DOI

      10.1089/hum.2010.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110505, KAKENHI-PROJECT-23500506
  • [Journal Article] ALS-TDPの動物モデル2011

    • Author(s)
      笹栗弘貴 , 横田隆徳 , 水澤英洋
    • Journal Title

      Clin Neurosci別冊

      Volume: vol. 29 Pages: 1024-1027

    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles2011

    • Author(s)
      Mayra A, Tomimitsu H, Kubodera T, Kobayashi M, Piao W, Sunaga F, Hirai Y, Shimada T, Mizusawa H, Yokota T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405 Issue: 2 Pages: 204-209

    • DOI

      10.1016/j.bbrc.2011.01.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Journal Article] TDP-43のげっ歯類、霊長類動物を用いた筋萎縮性側索硬化症モデル2011

    • Author(s)
      横田隆徳, 笹栗弘貴
    • Journal Title

      神経内科

      Volume: vol. 76 Pages: 275-280

    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] Propagation : prion-like mechanisms can explain spreading of motor neuronal death in amyotrophic lateral sclerosis?2011

    • Author(s)
      Kuwabara S, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82 Issue: 11 Pages: 1181-1182

    • DOI

      10.1136/jnnp-2011-300691

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Journal Article] TDP-43のげっ歯類、霊長類動物を用いた筋萎縮性側索硬化症モデル2011

    • Author(s)
      横田隆徳, 笹栗弘貴
    • Journal Title

      神経内科

      Volume: 76(3) Pages: 275-280

    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Journal Article] ALS-TDPの動物モデル2011

    • Author(s)
      笹栗弘貴, 横田隆徳, 水澤英洋
    • Journal Title

      Clinical Neuroscience別冊

      Volume: 29 Pages: 1024-1027

    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Journal Article] In Vivo application of an RNAi strategy for the Selective Suppression of a Mutant Allele2011

    • Author(s)
      Kubodera T, Yamada H, Anzai M, Ohira S, Yokota S, HiraiY, Mochizuki H, Shimada T, Mitani T, Mizusawa H, Yokota T
    • Journal Title

      Human Gene Therapy

      Volume: 22 Pages: 27-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] ALS-TDPの動物モデル2011

    • Author(s)
      笹栗弘貴, 横田隆徳, 水澤英洋
    • Journal Title

      Clin Neurosci別冊

      Volume: 29 Pages: 1024-1027

    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] Propagation : prion-like mechanisms can explain spreading of motor neuronal death in amyotrophic lateral sclerosis?2011

    • Author(s)
      Kuwabara S, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82 Pages: 1181-1182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Journal Article] HDL facilitates in vivo delivery of a-tocopherol-conj ugated siRNA to the brain2011

    • Author(s)
      Uno Y, Piao W, Nishina K, Miyata K, Mizusawa H, Yokota T
    • Journal Title

      Hum Gene Ther

      Volume: 22 Issue: 6 Pages: 711-719

    • DOI

      10.1089/hum.2010.083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039, KAKENHI-PUBLICLY-23110505
  • [Journal Article] siRNAによる神経変性疾患の遺伝子治療2009

    • Author(s)
      横田隆徳
    • Journal Title

      Bio Clinica 24

      Pages: 44-49

    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] siRNAによる神経変性疾患の遺伝子治療2009

    • Author(s)
      横田隆徳
    • Journal Title

      BioClinica 24

      Pages: 44-49

    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] MicroRNAと中枢神経系2009

    • Author(s)
      横田隆徳
    • Journal Title

      Brain Nerve 61

      Pages: 167-178

    • NAID

      40016469892

    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of a -Tocopherol2008

    • Author(s)
      Kazutaka Nishina, Toshinori Unno, Yoshitaka Uno, Takayuki Kubodera, Tadashi Kanouchi, Hidehiro Mizusawa Takanori Yokota
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] トランスポーターとアルツハイマー病2008

    • Author(s)
      西田陽一郎, 横田隆徳, 他
    • Journal Title

      Clinical Neuroscience 26

      Pages: 1111-1113

    • Data Source
      KAKENHI-PROJECT-20650054
  • [Journal Article] Efficient In Vivo delivery of siRNA to liver by conjugation ofα-Tocopherol2008

    • Author(s)
      Nishina K, Unno T, Uno Y, Kubodera T, Kanouchi T, Mizusawa H, Yokota T.
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol2008

    • Author(s)
      Kazutaka Nishina, Toshinori Unno, Yoshitaka Uno, Takayuki Kubodera, Tadashi Kanouchi, Hidehiro Mizusawa Takanori Yokota
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19650103
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008

    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol 23

      Pages: 1437-1447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] ALSの遺伝子治療2008

    • Author(s)
      久保寺隆行, 横田隆徳, 水深英洋
    • Journal Title

      Clinical Neuroscience 26

      Pages: 337-339

    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] ALSの遺伝子治療2008

    • Author(s)
      久保寺隆行、横田隆徳、水澤英洋
    • Journal Title

      Clinical Neuroscience 26

      Pages: 337-339

    • Data Source
      KAKENHI-PROJECT-19659222
  • [Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol.2008

    • Author(s)
      Nishina K, Unno T, Uno Y, Kubodera T, Kanouchi T, Mizusawa H, Yokota T:
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] 家族性筋萎縮性側索硬化症のRNA干渉を用いた遺伝子治療2008

    • Author(s)
      横田隆徳
    • Journal Title

      神経治療学 25

      Pages: 31-39

    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] MicroRNAと神経科学2008

    • Author(s)
      横田隆徳
    • Journal Title

      Brain and Nerve 61

      Pages: 167-176

    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] 家族性筋萎縮性側索硬化症のRNA干渉を用いた遺伝子治療2008

    • Author(s)
      横田隆徳
    • Journal Title

      神経治療学 25

      Pages: 31-39

    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vivo by recombinant adenovirus expressing short hairpin RNA.2008

    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient in vivo delivery of siRNA to liver by conjugation of a-tocopherol2008

    • Author(s)
      Nishina K. Unno T ; Uno Y. Kubodera T,. Kanouchi T, Mizusawa H, Yokota T
    • Journal Title

      Mol Ther 16

      Pages: 734-740

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient In Vivo delivery of siRNA to liver by conjugation of α-Tocopherol2008

    • Author(s)
      Nishina K, Unno T, Uno Y, Kubodera T, Kanouchi T, Mizusawa H, Yokota T.
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol2008

    • Author(s)
      Kazutaka Nishina, Toshinori Unno, Yoshitaka Uno, Takayuki Kubodera, Tadashi Kanouchi, Hidehiro Mizusawa Takanori Yokota
    • Journal Title

      Molecular Therapy 16

      Pages: 734-740

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659222
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008

    • Author(s)
      Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and invivo by recombinant adenovirus expressing short hairpin RNA2008

    • Author(s)
      Sakamoto N, Tanabe Y, YokotaT, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, TasakaM, Sakurai Y, Chen CH, YanoM, Ohkoshi s, Aoyagi Y, Maekawa s, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol 23

      Pages: 1437-1447

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] MicroRNAと神経科学2008

    • Author(s)
      横田隆徳
    • Journal Title

      Brain and Nerve 61

      Pages: 167-176

    • Data Source
      KAKENHI-PROJECT-20659138
  • [Journal Article] ALSの遺伝子治療2008

    • Author(s)
      久保寺隆行、横田隆徳、水澤英洋
    • Journal Title

      Clinical Neuroscience 26

      Pages: 337-339

    • Data Source
      KAKENHI-PROJECT-20023010
  • [Journal Article] siRNAの生体内における問題点2007

    • Author(s)
      久保寺隆行、横田隆徳
    • Journal Title

      BIO INDUSTRY 24(6)

      Pages: 22-28

    • Data Source
      KAKENHI-PROJECT-19659222
  • [Journal Article] Gene Therapy of Hereditary Diseases with RNA Interference2007

    • Author(s)
      Yokota T, Kubodera T. Yamada H, Unno T. Nishina K. Mitani T, Mizusawa H.
    • Journal Title

      Joint Annual Meeting of the Molecular Biology Society of Japan and the Japanese Biochemical Society

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.2007

    • Author(s)
      Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair D A, Mizusawa H, Matsuyama S
    • Journal Title

      Cell Death Differ 14

      Pages: 2058-2067

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] siRNAを用いたALSの遺伝子治療2007

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ (印刷中)

    • Data Source
      KAKENHI-PROJECT-18650103
  • [Journal Article] siRNA干渉によるALSの治療戦略2007

    • Author(s)
      横田隆徳
    • Journal Title

      Brain and Nerve 59

      Pages: 1187-1194

    • Data Source
      KAKENHI-PROJECT-19650103
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA2007

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Yamada H, Unno N, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H.
    • Journal Title

      Archives Neurology 64

      Pages: 145-146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19650103
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA2007

    • Author(s)
      Yokota T, et. al.
    • Journal Title

      Arch Neurol 64

      Pages: 145-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation2007

    • Author(s)
      Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S.
    • Journal Title

      Cell Death & Differentiation 14

      Pages: 2058-2067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse modely by transgenic small interfering RNA.2007

    • Author(s)
      Yokota T, Sasaguri H, Yamada H, Unno N, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H
    • Journal Title

      Arch Neurol 64

      Pages: 145-146

    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse modelby transgenic small interfering RNA.2007

    • Author(s)
      Yokota T, Sasaguri H, Yamada H, Unno N, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H.
    • Journal Title

      Archives of Neurology 64

      Pages: 145-146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] siRNAを用いたALSの遺伝子治療2007

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ。 (印刷中)

    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.2007

    • Author(s)
      Yokota T, et. al.
    • Journal Title

      Arch Neuroi 64

      Pages: 145-146

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model bytransgenic small interfering RNA.2007

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Yamada H, Unno N, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H.
    • Journal Title

      Archives Neurology 64

      Pages: 145-146

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] siRNA干渉によるALSの治療戦略2007

    • Author(s)
      横田隆徳
    • Journal Title

      Brain and Nerve 59

      Pages: 1187-1194

    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.2007

    • Author(s)
      Yokota T, Sasaguri H, Yamada H, Unno T, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H
    • Journal Title

      Arch Neurol 64

      Pages: 145-146

    • Data Source
      KAKENHI-PROJECT-18659256
  • [Journal Article] Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.2007

    • Author(s)
      Yokota T, lijima S, Kubodera T, Ishii K, Katakai Y, Ageyama N, Chen YW, Lee YJ, Unno T, Nishina K, Iwasaki Y. Maki N, Mizusawa H, Akari H
    • Journal Title

      Biochem Biophys Res Com 361

      Pages: 294-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA2007

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Yamada H, Unno N, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H.
    • Journal Title

      Archives Neurology 64

      Pages: 145-146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA2007

    • Author(s)
      Yokota T. Sasaguri H, Saito Y. Yamada H, Unno N, Yamamoto T Kubodera T, Anzai M. Mitani T, Mizusawa H
    • Journal Title

      Arch Neurol 64

      Pages: 145-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.2007

    • Author(s)
      Yokota T, Sasaguri H, Yamada H, Unno T, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H
    • Journal Title

      Arch Neurol 64

      Pages: 145-146

    • Data Source
      KAKENHI-PROJECT-18650103
  • [Journal Article] Clinical application of RNAi to neurodegenerative disease "Science for neurodegenerative disease"2007

    • Author(s)
      Yokota T, Takah ashi R.
    • Journal Title

      Nanzan-do

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.2007

    • Author(s)
      Yokota T, Iijima S, Kubodera T, Ishii K, Katakai Y, Ageyama N, Chen YW, Lee YJ, Unno T, Nishina K, Iwasaki Y, MakiN, Mizusawa H, Akari H
    • Journal Title

      Biochem Biophys Res Com 361

      Pages: 294-300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] siRNAを用いたALSの遺伝子治療2007

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ (印刷中)

    • Data Source
      KAKENHI-PROJECT-18659256
  • [Journal Article] Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku 70 acelylation2007

    • Author(s)
      Li Y. Yokota T, Gama V. Yoshida T, Gomez JA, Ishikawa K, Sasaguri H. Cohen NY Sinclair DA, Mizusawa H. Matsuyama S
    • Journal Title

      Cell Death Differ 14

      Pages: 2058-2067

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Ed by Takaku H, Yamamoto N. siRNA-based gene therapy for autosomal dominant disease of the nervous system. In RNAi therapeutics2007

    • Author(s)
      Yokota T.
    • Journal Title

      Transworld Research Network

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Clinical application of siRNA2007

    • Author(s)
      Yokota T.
    • Journal Title

      Neuro

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] RNA干渉によるアルツハイマー病治療の可能性。2006

    • Author(s)
      横田隆徳
    • Journal Title

      Progress in Medicine 55

      Pages: 441-445

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] siRNAiの核酸医薬としての可能性.2006

    • Author(s)
      横田隆徳
    • Journal Title

      分子細胞治療 5

      Pages: 231-236

    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.2006

    • Author(s)
      Hino T, Yokota T, Ito S, Nishina K, Kang Y-S, Mori S, Hori S, Kanda T, Terasaki T, Mizusawa H
    • Journal Title

      Biochemical and Biophysical Research Communications 340

      Pages: 263-267

    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse.2006

    • Author(s)
      Nishida Y, Yokota T, Takahashi T, Uchihara T, Jishage K, Mizusawa H
    • Journal Title

      Biochem Biophys Res Commun. 350

      Pages: 530-536

    • Data Source
      KAKENHI-PROJECT-18650102
  • [Journal Article] Transgenic siRNA increases the disease duration of ALS in a mouse model2006

    • Author(s)
      Yokota T, Saito Y, Sasaguri H, Mitani T, Anzai M, Miyagishi M, Mizusawa H
    • Journal Title

      Arch Neurol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells.2006

    • Author(s)
      Hino T, Yokota T, Ito S, Nishina K, Kang YS, Mori S, Hori S, Kanda T, Terasaki T, Mizusawa H:
    • Journal Title

      Biochem Biophys Res Com 340

      Pages: 263-267

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] 脳血管内皮細胞をターゲットとしたsiRNAを用いた遺伝子治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Neuroimmunology 14

      Pages: 141-145

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain.2006

    • Author(s)
      Ren YR, Nishida Y, Yoshimi K, Yasuda T, Jishage KI, Uchihara T, Yokota T, Mizuno Y, Mochizuki H
    • Journal Title

      J Neurochem. 98

      Pages: 1810-1816

    • Data Source
      KAKENHI-PROJECT-18650102
  • [Journal Article] siRNAの核酸医薬としての可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      分子細胞治療 5

      Pages: 231-236

    • Data Source
      KAKENHI-PROJECT-18650103
  • [Journal Article] A new RNAi strategy for selective suppression of a mutant allele to anv mutation2006

    • Author(s)
      Yamada H. Kubodera T, Yokota T. Mizusawa H.
    • Journal Title

      13th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] RNA干渉によるアルツハイマー病治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Progress in Medicine 26

      Pages: 441-445

    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells2006

    • Author(s)
      Hino T, Yokota T. Ito S. Nishina K, Kang YS, Mori S, Hori S. Kanda T. Terasald T. Mizusativa H
    • Journal Title

      Biochem Biophys Res Commun 340

      Pages: 263-267

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] 脳血管内皮をターゲットとしたsiRNAを用いた遺伝子治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Neuroimmunology 14

      Pages: 141-145

    • Data Source
      KAKENHI-PROJECT-18659256
  • [Journal Article] Liver toxicity induced by AAV delivered short hairpin RNA2006

    • Author(s)
      Unno T. Kubodera T. Murayama S, Ohira S. Nishina K. Igari T, Eishi Y. Hirai Y. Shimada T, Yokota T, Mizusawa H.
    • Journal Title

      13th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Adeno-associated virus serotype 8(AAV-8)-mediated shRNA delivery in vivo2006

    • Author(s)
      Chen Y, Yokota T, Kubodera T. Ohishi I, Li Y. Nishina K. Hirai Y. Shimada T. Mizusawa H.
    • Journal Title

      12th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient regulation of viral replication by systemically administered siRNA in a non-human primate surrogate model for hepatitis2006

    • Author(s)
      Yokota T, lijima S. Kubodera T. Ishii K. Ageyama N. Yingwei C. Lee J-J, Maki N, Mizusawa H, Akari H.
    • Journal Title

      12th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] RNA干渉によるアルツハイマー病治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Progress in Medicine 26

      Pages: 441-445

    • Data Source
      KAKENHI-PROJECT-18650103
  • [Journal Article] RNA干渉によるアルツハイマー病治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Progress in Medicine 26

      Pages: 441-445

    • Data Source
      KAKENHI-PROJECT-18659256
  • [Journal Article] 脳血管内皮をターゲットとしたsiRNAを用いた遺伝子治療の可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      Neuroimmunology 14

      Pages: 141-145

    • Data Source
      KAKENHI-PROJECT-18650103
  • [Journal Article] Tranegenic siRNA holls ALS in a mouse model2006

    • Author(s)
      Yokota T. Sasaguri H, Saito Y. Mitani T. Mizusawa H.
    • Journal Title

      Neuro

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] RNAiの核酸医薬としての可能性。2006

    • Author(s)
      横田隆徳
    • Journal Title

      分子細胞治療 (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Efficient delivery of siRNA targeting brain endothelial cells2006

    • Author(s)
      Nishina K, Yokota T, Hino T, Yoshida M, Terasaki T, MizusaNva H.
    • Journal Title

      12th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient regulation of viral replication by systemically administered siRNA in a non-human primate surrogate model for hepatitis C.2006

    • Author(s)
      Yokota T. Kubodera T, Unno N, Chen Y, Nishina K. Mizusawa H, Akari H.
    • Journal Title

      12th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] In viva analysis of new RNAi strategy : selective suppression of a mutant allele to any mutation2006

    • Author(s)
      Kubodera T, Yokota T, Saito Y, Mizusawa H.
    • Journal Title

      12th annual meeting of Japan Society of Gene Therapy

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] siRNAの核酸医薬としての可能性2006

    • Author(s)
      横田隆徳
    • Journal Title

      分子細胞治療 5

      Pages: 231-236

    • Data Source
      KAKENHI-PROJECT-18659256
  • [Journal Article] RNAiの神経疾患への応用2005

    • Author(s)
      横田隆徳
    • Journal Title

      脳神経外科速報 15(8)

      Pages: 765-770

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiの神経変性疾患治療への応用。2005

    • Author(s)
      横田隆徳
    • Journal Title

      細胞工学 24

      Pages: 378-382

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiによるウイルス複製抑制2005

    • Author(s)
      横田隆徳
    • Journal Title

      ウイルス 55(1)

      Pages: 1-8

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiの神経変性疾患治療への応用2005

    • Author(s)
      横田隆徳
    • Journal Title

      細胞工学 24

      Pages: 378-382

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] RNAiの神経疾患への応用2005

    • Author(s)
      横田隆徳
    • Journal Title

      脳神経外科速報 15(8)

      Pages: 765-770

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] RNA干渉による神経変性疾患の遺伝子治療の現状2005

    • Author(s)
      横田隆徳
    • Journal Title

      Curr Insight Neurol Sci 13(3)

      Pages: 177-179

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] New RNAi strategy for selective suppression of a mutant allele in polyglutamine disease.2005

    • Author(s)
      Kubodera T, Yokota T, Ishikawa K, Mizusawa H
    • Journal Title

      Oligonucleotides 15

      Pages: 298-302

    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA.2005

    • Author(s)
      Hori S, Ohtsuki S, Ichinowatari M, Yokota T, Ohtsuki M, Terasaki T
    • Journal Title

      J Neurochem 93

      Pages: 63-71

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.2005

    • Author(s)
      Akashi H, Miyagishi M, Yokota T, Watanabe T, Hino T, Nishina K, Kobara M, Taira K.
    • Journal Title

      Molecular Bio Systems 1

      Pages: 382-390

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いたウイルス複製抑制。2005

    • Author(s)
      横田隆徳
    • Journal Title

      ウイルス 55

      Pages: 1-8

    • NAID

      10016449211

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] New RNAi strategy for selective suppression of mutant allele in polyglutamine disease.2005

    • Author(s)
      Kubodera T, Yokota T, Ishikawa K, Mizusawa H
    • Journal Title

      Oligonucleotides 15

      Pages: 298-302

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] Transgenic siRNA halted amyotrophic lateral sclerosis in a mouse model.2005

    • Author(s)
      Saito Y, Yokota T, Mitani T, Anzai M, Miyagisni M, Taira K, Mizusawa H
    • Journal Title

      J Biol Chem 280

      Pages: 42826-42830

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] Transgenic siRNA halted amyotrophic lateral sclerosis in a mouse model.2005

    • Author(s)
      Saito Y, Yokota T, Mitani T, Anzai M, Miyagishi M, Taira K, Mizusawa H
    • Journal Title

      J Biol Chem 280

      Pages: 42826-42830

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiによるウイルス複製抑制2005

    • Author(s)
      横田隆徳
    • Journal Title

      ウイルス 55(1)

      Pages: 1-8

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] RNA干渉による神経変性疾患の遺伝子治療の現状。2005

    • Author(s)
      横田隆徳
    • Journal Title

      Curr Insight Neurol Sci 13

      Pages: 8-9

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model.2005

    • Author(s)
      Saito Y, Yokota T, Mitani T, Ito K, Anzai M, Miyagishi M, Taira K, Mizusawa H.
    • Journal Title

      Biological Chemistry 280(52)

      Pages: 42826-42830

    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] RNA干渉を用いた神経疾患の遺伝子治療。2005

    • Author(s)
      横田隆徳
    • Journal Title

      脳神経外科速報 15

      Pages: 765-770

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNA interference as a tool for producing knockdown mice.2005

    • Author(s)
      Mitani T, Yokota T
    • Journal Title

      J Mamm Ova Res 22

      Pages: 139-151

    • NAID

      10016956052

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] RNA干渉による神経変性疾患の遺伝子治療の現状2005

    • Author(s)
      横田隆徳
    • Journal Title

      Curr Insight Neurol Sci 13(3)

      Pages: 177-179

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiの神経変性疾患治療への応用2005

    • Author(s)
      横田隆徳
    • Journal Title

      細胞工学 24

      Pages: 378-382

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] New RNAi strategy for selective suppression of mutant allele in polyglutamine disease.2005

    • Author(s)
      Kubodera T, Yokota T, Ishikawa K, Mizusawa H
    • Journal Title

      Oligonucleotides 15

      Pages: 298-302

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA.2005

    • Author(s)
      Hori S, Ohtsuki S, Ichinowatari M, Yokota T, Ohtsuki M, Terasaki T
    • Journal Title

      J Neurochem 93

      Pages: 63-71

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells2005

    • Author(s)
      Hino T, Yokota T, Ito S, Nishina K, Kang Y -S, Mori S, Hori S, Kanda T, Terasaki T, Mizusawa H.
    • Journal Title

      Biochem Biophys Res Com 340

      Pages: 263-267

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] In vivo delivery of small interfering RNA targeting brain capillary endothelial cells2005

    • Author(s)
      Hino T, Yokota T, Ito S, Nishina K, Kang Y-S, Mori S, Hori S, Kanda T, Terasaki T, Mizusawa H.
    • Journal Title

      Biochem Biophys Res Com 340

      Pages: 263-267

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNA interference as a tool for producing knockdown mice.2005

    • Author(s)
      Mitani T, Yokota T
    • Journal Title

      J Mamm Ova Res 22

      Pages: 139-151

    • NAID

      10016956052

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5'untranslated region of the gene encoding a protein with spectrin repeat and rho guanine-nucleotide exchange-factor domains.2005

    • Author(s)
      Ishikawa K, Toru S, Tsunemi T, Li M, Kobayashi K, Yokota T, Amino T, Mizusawa H et al.
    • Journal Title

      Am.J.Hum.Genet 77

      Pages: 280-296

    • Data Source
      KAKENHI-PROJECT-17209031
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.2005

    • Author(s)
      Akashi H, Miyagishi M, Yokota T, Watanabe T, Hino T, Nishina K, Kohara M, Taira K
    • Journal Title

      Molecular Bio Systems 1

      Pages: 382-390

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA.2005

    • Author(s)
      Akashi H, Miyagishi M.Yokota T, Watanabe T, Hino T, Nishina K, Kohara M, Taira K
    • Journal Title

      Molecular Bio Systems 1

      Pages: 382-390

    • Data Source
      KAKENHI-PROJECT-17659260
  • [Journal Article] siRNA-based inhibition of superoxide dismutase expression; potential use in familial Amyotrophic lateral sclerosis.2004

    • Author(s)
      Yokota T, Miyagishi M, Hino T, Matsumura R, Andria T, Urushidani M, Rao RV, Takahashi R, Bredesen DE, Taira K, Mizusawa H
    • Journal Title

      Biochem Biophys Res Com 314

      Pages: 283-291

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] siRNA-based inhibition of mutant ataxin 3 gene expression2004

    • Author(s)
      Li Y, Yokota T, et al.
    • Journal Title

      Annals of Neurology 56

      Pages: 124-129

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いたウイルス性肝炎の遺伝子治療2004

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ 208・8

      Pages: 669-673

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.2004

    • Author(s)
      Yokota T, et al.
    • Journal Title

      Biochem Biophys Res Com 314

      Pages: 283-291

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA.2004

    • Author(s)
      Li Y, Yokota T, Taira K, Mizusawa H
    • Journal Title

      Ann Neurol 56

      Pages: 124-129

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いたウイルス性肝炎の遺伝子治療2004

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ 208

      Pages: 669-676

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] IRF-1 and IRF-2 distinctively up-regulate gene expression and production of IL-7 in human intestinal epithelial cells.2004

    • Author(s)
      Ohshima S, Yokota T, et al.
    • Journal Title

      Mol Cell Biol 24

      Pages: 6298-6310

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] 神経変性疾患へのRNAiの臨床応用の展望。2004

    • Author(s)
      横田隆徳
    • Journal Title

      最新医学 21

      Pages: 138-144

    • NAID

      40006151866

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] siRNAを用いたC型肝炎の遺伝子治療2004

    • Author(s)
      横田隆徳, 水澤英洋
    • Journal Title

      Molecular Medicine 41

      Pages: 36-43

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] IRF-1 and IRF-2 distinctively up-regulate gene expression and production of IL-7 in human intestinal epithelial cells.2004

    • Author(s)
      Ohshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Kanai T, Watanabe M
    • Journal Title

      Mol Cell Biol 24

      Pages: 6298-6310

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiの医療への応用2004

    • Author(s)
      横田隆徳
    • Journal Title

      実験医学 22・4

      Pages: 485-491

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いた遺伝子治療の可能性2004

    • Author(s)
      横田隆徳
    • Journal Title

      臨床免疫 42・4

      Pages: 494-498

    • NAID

      40006464994

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いたC型肝炎の遺伝子治療。2004

    • Author(s)
      横田隆徳, 水澤英洋
    • Journal Title

      Molecular Medicine 41

      Pages: 36-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いた遺伝子治療の可能性。2004

    • Author(s)
      横田隆徳
    • Journal Title

      臨床免疫 42

      Pages: 494-498

    • NAID

      40006464994

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] siRNAを用いたC型肝炎の遺伝子2004

    • Author(s)
      横田隆徳, 水澤英洋
    • Journal Title

      Molecular Medicine 41・1

      Pages: 36-43

    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] 神経変性疾患へのRNAiの臨床応用の展望2004

    • Author(s)
      横田隆徳
    • Journal Title

      最新医学 21

      Pages: 138-144

    • NAID

      40006151866

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] RNAiの医療への応用。2004

    • Author(s)
      横田隆徳
    • Journal Title

      実験医学 22

      Pages: 485-491

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] 神経変性疾患研究におけるsiRNAを用いた遺伝子発現制御。2004

    • Author(s)
      横田隆徳
    • Journal Title

      バイオインダストリー 21

      Pages: 43-51

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] siRNA-based inhibition of superoxide dismutase expression ; potential use in familial Amyotrophic lateral sclerosis.2004

    • Author(s)
      Yokota T, Miyagishi M, Hino T, Matsumura R, Andria T, Urushidani M, Rao RV, Takahashi R, Bredesen DE, Taira K, Mizusawa H
    • Journal Title

      Biochem Biophys Res Com 314

      Pages: 283-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] RNAiを用いたウイルス性肝炎の遺伝子治療。2004

    • Author(s)
      横田隆徳
    • Journal Title

      医学のあゆみ 208

      Pages: 669-673

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] Sequence-dependent and independent inhibition of mutant ataxin 3 by short interfering RNA.2004

    • Author(s)
      Li Y, Yokota T, et al.
    • Journal Title

      Annals of Neurology 56

      Pages: 124-129

    • Data Source
      KAKENHI-PROJECT-16650091
  • [Journal Article] Efficient in vivo delivery of siRNA to liver by conjugation of a-tocopherol

    • Author(s)
      Yokota T, Unno T, Nishina K, Uno Y. Kubodera T, Kanouchi T, Mizusawa H.
    • Journal Title

      Keystone Symposim, RNAi, miRNA and non-coding RNA

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] In vivo application of siRNA/shRNA

    • Author(s)
      Yokota T.
    • Journal Title

      Bio-Japan Symposium

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motorneuron death by targeting Derlin-1.

    • Author(s)
      Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H
    • Journal Title

      Gene Dev (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.

    • Author(s)
      Yokota T. Kubodera T, Hirabayashi K, Ishii K. Maki N, Mizusawa H, En.omoto N. Yano J, Akari H.
    • Journal Title

      20th The Japan Society of Hepatology

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Tranegenic siRNA holts ALS in a mouse model

    • Author(s)
      Yokota T. Sasaguri H. Saito Y, Mitani T, Mizusawa H.
    • Journal Title

      59th AAN annual meeting

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Transgenic siRNA increases the disease duration of ALS in a mouse model

    • Author(s)
      Yokota T, Saito Y, Sasaguri H, Mitani T, Anzai M, Miyagishi M, Mizusawa H
    • Journal Title

      Arch Neurol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390204
  • [Journal Article] ALS-linked mutant SOD I induces ER stress- and ASK I -dependent motor neuron death by targeting Derlin-1

    • Author(s)
      Nishitoh H, Kadowaki H, Nagai A. Maruyama T, Yokota T. Fukutomi H, Noguchi T, Matsuyama A, Takeda K, Ichijo H.
    • Journal Title

      Gene Dev (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovi us expressing short hairpin RNA

    • Author(s)
      Sakamoto N. Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y Chen CH, Yano M, Ohkoshi S. Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
    • Journal Title

      J Gastro Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Journal Article] Gene therapy with siRNA targeting brain endothelial cells

    • Author(s)
      Yokota T.
    • Journal Title

      Neuroimmunology

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2014

    • Inventor(s)
      片岡一則, 安楽泰孝, 西山伸宏, 宮田完二郎, 石井武彦, 松本有, 福里優, 溝口明祐, 横田隆徳, 桑原宏哉, 仁科一隆, 水澤英洋
    • Industrial Property Rights Holder
      国立大学法人東京大学、国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-096935
    • Filing Date
      2014-05-08
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2014

    • Inventor(s)
      片岡一則、安楽泰孝、西山伸宏、宮田完二郎、石井武彦、松本有、溝口明祐、横田隆徳、桑原宏哉、仁科一隆、水澤英洋
    • Industrial Property Rights Holder
      国立大学法人 東京大学 国立大学法人 東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-21
    • Acquisition Date
      2017-02-10
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Patent] 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法2013

    • Inventor(s)
      片岡一則、安楽泰孝、西山伸宏、宮田完二郎、石井武彦、松本有、福里優、溝口明祐、横田隆徳、桑原宏哉、仁科一隆、水澤英洋
    • Industrial Property Rights Holder
      国立大学法人東京大学、国立大学法人東京医科歯科大
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-22
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Patent] 変異MJD遺伝子の発現を特異的に抑制するsiRNA2010

    • Inventor(s)
      横田隆徳
    • Industrial Property Rights Holder
      科学技術振興機構
    • Acquisition Date
      2010-02-26
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Patent] ES細胞を用いた新しいsiRNAトランスジェニックマウスの作製方法の開発2007

    • Inventor(s)
      横田隆徳 三谷匡 笹栗弘貴 水澤英洋
    • Industrial Property Rights Holder
      近畿大学
    • Filing Date
      2007-05-12
    • Data Source
      KAKENHI-PROJECT-19650103
  • [Patent] Gene delivery of siRNA with new endogenous lipoprotein2007

    • Inventor(s)
      Yokota T, et. al.
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Patent] あらゆる遺伝子を標的とすることを可能としたsiRNAトランスジェニックマウスの新規作製方法2007

    • Inventor(s)
      横田隆徳、他3名
    • Industrial Property Rights Holder
      近畿大学
    • Industrial Property Number
      2007-118962
    • Filing Date
      2007-04-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Patent] Gene delivery of siRNA with new endogenous lipoprotein.2007

    • Inventor(s)
      Yokota T, Nishina K, Mizusawa H Unno T,
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-11-30
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Patent] Gene delivery of siRNA with new endogenous lipoprotein.2007

    • Inventor(s)
      Yokota T, Nishina K, Mizusawa H Unno T
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Patent] A-beta蛋白の排泄機構の機能低下によるアルツハイマー病の新規モデル非ヒト動2006

    • Inventor(s)
      横田隆徳、他3名
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2006-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Patent] A-βの排泄機構の機能低下によるアルツハイマー病の新規モデル非ヒト動物2006

    • Inventor(s)
      横田 隆徳, 水澤 英洋, 西田 陽一郎, 寺崎 哲也
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Filing Date
      2006-04-17
    • Data Source
      KAKENHI-PROJECT-18650102
  • [Patent] A-beta蛋白の排泄機構の機能低下によるアルツハイマー病の新規モデル非ヒト動物2006

    • Inventor(s)
      横田隆徳、他3名
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Acquisition Date
      2006-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Altered brain energy metabolism related to astrocytes in Alzheimer's disease2023

    • Author(s)
      Kosei Hirata,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Harutsugu Tatebe,Maiko Ono, Naomi Kokubo,Asaka Oyama, Hitoshi Shinotoh,Keisuke Takahata,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takanori Yokota,Takahiko Tokuda,Makoto Higuchi, Yuhei Takado
    • Organizer
      ISMRM JPC 2023
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] Altered brain energy metabolism related to astrocytes in Alzheimer's disease2023

    • Author(s)
      Kosei Hirata,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Harutsugu Tatebe,Maiko Ono, Naomi Kokubo,Asaka Oyama, Hitoshi Shinotoh,Keisuke Takahata,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takanori Yokota,Takahiko Tokuda,Makoto Higuchi, Yuhei Takado
    • Organizer
      ISN-ESN 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] Altered brain energy metabolism related to astrocytes in Alzheimer's disease2023

    • Author(s)
      Kosei Hirata,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Harutsugu Tatebe,Maiko Ono, Naomi Kokubo,Asaka Oyama, Hitoshi Shinotoh,Keisuke Takahata,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takanori Yokota,Takahiko Tokuda,Makoto Higuchi, Yuhei Takado
    • Organizer
      第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] Altered brain energy metabolism related to astrocytes in Alzheimer's disease2023

    • Author(s)
      Kosei Hirata,Yuhei Takado,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Naomi Kokubo,Harutsugu Tatebe,Hong Zhang,Hitoshi Shinotoh,Keisuke Takahata,Maiko Ono,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takahiko Tokuda,Takanori Yokota,Makoto Higuchi
    • Organizer
      第25回日本ヒト脳機能マッピング学会
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] 神経難病に本領を発揮しうる核酸医薬の最前線2022

    • Author(s)
      横田隆徳
    • Organizer
      Web exchange meeting Neurology
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] Altered Brain Energy Metabolism Related to Astrocytes in Tauopathies2022

    • Author(s)
      Kosei Hirata,Yuhei Takado,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Naomi Kokubo,Harutsugu Tatebe,Hong Zhang,Hitoshi Shinotoh,Keisuke Takahata,Maiko Ono,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takahiko Tokuda,Takanori Yokota,Makoto Higuchi
    • Organizer
      Alzheimer's Association International Conference 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] 進行性核上性麻痺患者におけるアストロサイト活性度の評価2022

    • Author(s)
      平田浩聖,松岡究,遠藤浩信,互健二,小久保奈緒美,篠遠仁,高畑圭輔,小野麻衣子,河村和紀,張明栄,島田斉,小畠隆行,須原哲也,横田隆徳 樋口真人,高堂裕平
    • Organizer
      第16回パーキンソン病・運動障害疾患コングレス
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] Efficacy of nanomicelle-encapsulated anti-amyloid β oligomer fragment antibody in AD pathology2022

    • Author(s)
      三條 伸夫, 天野 晶子, 荒木 亘, 安楽 泰孝, 中木戸 誠, 松原 悦朗, 平田 浩聖, 永田 哲也, 津本 浩平, 片岡 一則, 横田 隆徳
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] DNA/RNAヘテロ核酸医薬の創製2022

    • Author(s)
      横田隆徳
    • Organizer
      Blue Bird セミナー
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] Altered Brain Energy Metabolism Related to Astrocytes in Tauopathies2022

    • Author(s)
      Kosei Hirata,Yuhei Takado,Kiwamu Matsuoka,Kenji Tagai,Hironobu Endo,Naomi Kokubo,Harutsugu Tatebe,Hong Zhang,Hitoshi Shinotoh,Keisuke Takahata,Maiko Ono,Takayuki Obata,Kazunori Kawamura,Ming-Rong Zhang,Hitoshi Shimada,Takahiko Tokuda,Takanori Yokota,Makoto Higuchi
    • Organizer
      第63回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K18268
  • [Presentation] ヘテロ2本鎖核酸の開発2021

    • Author(s)
      横田隆徳
    • Organizer
      日本薬物動態学会第36回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] DNA/RNAヘテロ2本鎖核酸の開発2021

    • Author(s)
      横田隆徳
    • Organizer
      2021年度日本分光学会NMR分光部会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] Development of heteroduplex oligonucleotides for central nervous system by systemic administration2021

    • Author(s)
      Takanori Yokota
    • Organizer
      PACIFICHEM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] ヘテロ核酸の開発2021

    • Author(s)
      横田隆徳
    • Organizer
      第3回JBA創薬モダリティ基盤研究会
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 脊髄性筋萎縮症の診断と治療2021

    • Author(s)
      横田隆徳
    • Organizer
      第51回日本臨床神経生理学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 血液脳関門通過型ヘテロ核酸の開発2021

    • Author(s)
      横田隆徳
    • Organizer
      第39回日本神経治療学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] ついに実現した核酸医薬2020

    • Author(s)
      横田隆徳
    • Organizer
      高分子学会 第69回高分子討論会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 核酸医薬の現状と今後の展望2020

    • Author(s)
      横田隆徳
    • Organizer
      日本人類遺伝学会第65回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 中枢神経疾患に対する核酸医薬2020

    • Author(s)
      横田隆徳
    • Organizer
      第39回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] New Stage of DNA/RNA Heteroduplex Oligonucleotide2020

    • Author(s)
      Takanori Yokota
    • Organizer
      AsianTIDES: Oligonucleotide & Peptide Therapeutics
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 中枢神経疾患に対する核酸医薬2020

    • Author(s)
      横田隆徳
    • Organizer
      39回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 核酸医薬とは何か2019

    • Author(s)
      横田隆徳
    • Organizer
      第37回日本神経治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] Systemically administered DNA/RNA heteroduplex oligonucleotides that can efficiently regulate CNS Genes2019

    • Author(s)
      Takanori Yokota
    • Organizer
      EuroTIDES
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] An efficient drug delivery system across the BBB by utilizing Glycemic control.2018

    • Author(s)
      Hiroya Kuwahara, Yasutaka Anraku, Kazunori Kataoka, Takanori Yokota
    • Organizer
      第41回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 血液脳関門を効率的に通過する脳へのドラッグデリバリーシステムの開発2018

    • Author(s)
      桑原宏哉,安楽泰孝,福里優,石井武彦,新田佳子,松本有,藤加珠子,宮田完二郎,内田智士,仁科一隆,長田健介,位高啓史,水澤英洋,片岡一則,横田隆徳
    • Organizer
      第36回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 血液脳関門を高効率に通過を可能にした新規の薬剤送達技術の開発2018

    • Author(s)
      横田隆徳
    • Organizer
      第30回日本神経免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] ヘテロ2 本鎖核酸の開発2017

    • Author(s)
      横田隆徳
    • Organizer
      創薬薬理フォーラム 第25 回シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] 難治性脳神経系疾患の治療を指向した高分子ミセルの構築2017

    • Author(s)
      安楽泰孝、桑原宏哉、横田隆徳、片岡一則
    • Organizer
      第66回高分子討論会
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Expression of sphingosine-1-phosphate receptor 1 in leptomeningeal arteries is upregulated and its agonist improves neurological outcome in ischemic stroke in mice2017

    • Author(s)
      Iwasawa E, Li FY, Ishibashi S, Ichijo M, Miki K, Yokota T.
    • Organizer
      XXIII World Congress of Neurology
    • Place of Presentation
      KYOTO INTERNATIONAL CONFERENCE CENTER, Kyoto
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Heteroduplex oligonucleotide reduced gene expression in focal ischemic brain in mice2017

    • Author(s)
      Li L, Ishibashi S, Iwasawa E, Song J, Ichijo M, Zhang Y, Piao W, Yoshida K, Kuwahara H, Yoshioka K, Nagata T, Yokota T.
    • Organizer
      STROKE2017
    • Place of Presentation
      大阪国際会議場, 大阪
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] ヘテロ2本鎖核酸の開発2017

    • Author(s)
      横田隆徳
    • Organizer
      創薬薬理フォーラム第25回シンポジウム
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] GENE SILENCING EFFECT OF HETERODUPLEX OLIGONUCLEOTIDE AND ITS BIODISTRIBUTION IN NEURONS AND BRAIN ENDOTHELIAL CELLS AFTER ISCHEMIA2017

    • Author(s)
      Li L, Ishibashi S, Iwasawa E, Song J, Ichijo M, Zhang Y, Piao W, Yoshida K, Kuwahara H, Yoshioka K, Nagata T, Yokota T
    • Organizer
      XXIII World Congress of Neurology
    • Place of Presentation
      KYOTO INTERNATIONAL CONFERENCE CENTER, Kyoto
    • Year and Date
      2017-09-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] ヘテロ2 本鎖核酸の開発2017

    • Author(s)
      横田隆徳
    • Organizer
      遺伝子デリバリー研究会、第17 回夏季セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06109
  • [Presentation] Modulation of blood-brain barrier function by heteroduplex oligonucleotide in vivo2017

    • Author(s)
      H. Kuwahara, J. Song, T. Shimoura, K. Yoshida-Tanaka, T. Mizuno, T. Mochizuki, K. Nishina, T. Nagata, H. Kusuhara, T. Yokota
    • Organizer
      The 40th Annual Meeting of the Japan Neuroscience Society
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] SILENCING OF MALAT1 LONG NON-CODING RNA WITH DNA/RNA HETERODUPLEX OLIGONUCLEOTIDES EXACERBATES CEREBRAL ISCHEMIA2017

    • Author(s)
      Ishibashi S, Li L, Iwasawa E, Song J, Ichijo M, Zhang Y, Piao W, Yoshida K, Kuwahara H, Yoshioka K, Nagata T, Yokota T.
    • Organizer
      XXIII World Congress of Neurology
    • Place of Presentation
      KYOTO INTERNATIONAL CONFERENCE CENTER, Kyoto
    • Year and Date
      2017-09-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 血液脳関門を効率的に通過する高分子ミセルの開発2017

    • Author(s)
      安楽泰孝、桑原宏哉、福里優、溝口明祐、藤加珠子、松本有、横田隆徳、片岡一則
    • Organizer
      第26回インテリジェント材料・システムシンポジウム
    • Place of Presentation
      東京女子医科大学先端生命医科学研究所(東京都、新宿区)
    • Year and Date
      2017-01-11
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNAヘテロ2 本鎖核酸2017

    • Author(s)
      横田隆徳
    • Organizer
      Bio Japan 2017
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Novel oligonucleotide based on DNA/RNA heteroduplex structures2016

    • Author(s)
      Kazutaka Nishina, Kotaro Yoshioka, Tomoko Nishina, Hiroya Kuwahara, Tetsuya Nagata, Takanori Yokota
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県、神戸市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNA heteroduplex oligonucleotide ; a 3rd class of oligonucleotide drug2016

    • Author(s)
      T. Yokota
    • Organizer
      第32回日本DDS学会学術集会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡県、静岡市)
    • Year and Date
      2016-07-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Heteroduplex Oligonucleotide reduced gene expression in focal ischemic brain in mice2016

    • Author(s)
      Li F, Ishibashi S, Yoshioka K, Wada T, Ichijo M, Iwasawa E, Song J, Zhang Y, Yokota T
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Creation of the hypoxia-specific oligonucleotide therapeutics system with intracellular environment-responsible Peptide Ribonucleic Acids (PRNAs): Synthesis and properties of new type of chimeric PRNA derivatives with 3’-DNA moiety introduced at N-terminus of PRNA2016

    • Author(s)
      Inagaki M, Uematsu R, Araki Y, Sakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      Campus Asia Summer School Symposium 2016
    • Place of Presentation
      Tohoku Univ, Sendai, Japan
    • Year and Date
      2016-08-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] A novel platform technology to regulate the blood-brain barrier in vivo2016

    • Author(s)
      Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県、神戸市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Creation of hypoxia specific oligonucleotide therapeutics system with intracellular environment-responsible Peptide Ribonucleic Acids (PRNAs): ― Tuning of on - off switching pH of PRNA for optimization of hypoxia cell specificity2016

    • Author(s)
      Asai M, Uematsu R, Araki Y, Nakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      Campus Asia Summer School Symposium 2016
    • Place of Presentation
      Tohoku Univ, Sendai, Japan
    • Year and Date
      2016-08-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 認知症に対する新規分子標的治療の開発2016

    • Author(s)
      横田隆徳
    • Organizer
      第35回日本認知症学会総会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2016-12-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing2016

    • Author(s)
      T. Yokota
    • Organizer
      3rd Internatioal Conference on Biomaterials Science in Tokyo (ICBS2016)
    • Place of Presentation
      Ito Hall located at The University of Tokyo (Tokyo, Japan)
    • Year and Date
      2016-11-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNA Heteroduplex Oligonucleotide as a Novel Concept of Therapeutic Oligonucleotide2016

    • Author(s)
      T. Yokota
    • Organizer
      IBC's 8th Annual TIDES Oligonucleotide and Peptide
    • Place of Presentation
      The Westin Miyako Kyoto (Kyoto, Japan)
    • Year and Date
      2016-02-25
    • Description
      【発表確定】
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] ALSに対する核酸医薬治療2016

    • Author(s)
      横田隆徳
    • Organizer
      第34回日本神経治療学会総会
    • Place of Presentation
      米子コンベンションセンターBIG SHIP(鳥取県、米子市)
    • Year and Date
      2016-11-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Upregulation and distribution of sphingosine-1-phosphate receptor 1 in acute ischemic stroke2016

    • Author(s)
      Iwasawa E, Ishibashi S, Ichijo M, Li F, Yokota T
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] DNA/RNA heteroduplex oligonucleotide2016

    • Author(s)
      T. Yokota
    • Organizer
      12th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      Centre Mont-Royal (Montreal, Canada)
    • Year and Date
      2016-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Creation of Ischemia-Specifi c Oligonucleotide Therapeutics System with Intracellular Environmental Condition - Responsive Peptide Ribonucleic Acids (PRNAs)2016

    • Author(s)
      Wada T, Uematsu R, Asai M, Inagaki M, Sugai H, Araki Y, Sakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      The 43nd International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kumamoto Univ, Kumamoto
    • Year and Date
      2016-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] New platform technology to regulate the blood-brain barrier function in vivo2016

    • Author(s)
      Hiroya Kuwahara, Takahiro Shimoura, Jindong Song, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Masaki Ohyagi, Kazutaka Nishina, Tetsuya Nagata, Hiroyuki Kusuhara, Takanorl Yokota
    • Organizer
      19th International Symposium on Signal Transduction at the Blood-Brain Barriers
    • Place of Presentation
      University of Copenhagen (Copenhagen, Denmark)
    • Year and Date
      2016-09-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] A new therapeutic oligonucleotide to regulate the blood-brain barrier in vivo2016

    • Author(s)
      H. Kuwahara, T. Shimoura, J. Song, KY. Tanaka, K. Nishina, T. Nagata, T. Yokota
    • Organizer
      Barcelona BioMed Conferences on the Blood-Brain Barrier
    • Place of Presentation
      Barcelona Institute for Science and Technology (Barcelona, Spain)
    • Year and Date
      2016-02-25
    • Description
      【発表確定】
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Creation of the ischemia-specific oligonucleotide therapeutics system with intracellular environment-responsive Peptide Ribonucleic Acids (PRNAs) : Development of half-gamer type chimeric PRNA-DNA-LNA derivatives2016

    • Author(s)
      Inagaki M, Uematsu R, Unabara D, Araki Y, Nakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      The 43nd International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Kumamoto Univ, Kumamoto, Japan
    • Year and Date
      2016-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 核酸医薬を用いた遺伝子治療の展望2015

    • Author(s)
      横田隆徳
    • Organizer
      第33回日本神経治療学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-28
    • Description
      【発表確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 血液脳関門の機能を制御する新規核酸医薬の開発2015

    • Author(s)
      下浦貴大, 桑原宏哉, 宋金東, 田中規恵, 仁科一隆, 永田哲也, 横田隆徳
    • Organizer
      BMB2015 第38回日本分子生物学会年会, 第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-03
    • Description
      【発表確定】
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing2015

    • Author(s)
      T. Yokota
    • Organizer
      第21回日本遺伝子治療学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-07-26
    • Description
      【発表確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] S1PR1 expression and endothelial cell proliferation after focal ischemia in mice2015

    • Author(s)
      石橋哲、一條真彦、李富宝、三木 一徳、水澤 英洋、横田隆徳
    • Organizer
      第56回日本神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Oligonucleotide reduced gene expression in focal ischemic brain in mice2015

    • Author(s)
      FuYing Li、石橋哲、一條真彦、和田健彦、横田隆徳
    • Organizer
      第56回に本神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Creation of hypoxia specific oligonucleotide therapeutics system with intracellular environment-responsible peptide ribonucleic acids (PRNAs): Tuning and optimization of on &#8211; off switching pH of PRNA for hypoxia specificity2015

    • Author(s)
      Asai M, Uematsu R, Araki Y, Nakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] A new drug delivery system across the blood-brain barrier into brain2015

    • Author(s)
      H. Kuwahara, Y. Anraku, Y. Fukusato, K. Nitta, A. Mizoguchi, K. Nishina, H. Mizusawa, K. Kataoka, T. Yokota
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2015-05-20
    • Description
      【発表確定】
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 第3の核酸医薬の「ヘテロ二重鎖核酸」の開発2015

    • Author(s)
      横田隆徳
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-17
    • Description
      【発表確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 構造制御に基づく高機能核酸医薬用人工核酸の開 発 ― モデュール法によるペプチドリボ核酸(PRNA)の構造・ 機能制御への新戦略2015

    • Author(s)
      和田健彦, 上松亮平, 菅井祥加, 浅井光夫, 稲垣 雅仁, 荒木保幸, 坂本清志, 樫田啓, 浅沼浩之, 石橋哲, 横田隆徳
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-15
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 中枢神経系細胞への選択的取り込みを志向したデュアルリガンド搭載型高分子ミセルの構造最適化2015

    • Author(s)
      渡邉拓也, 溝口明祐, 安楽泰孝, 福里優, 堀真緒, J. -Y. Ahn, 新田佳子, 桑原宏哉, 横田隆徳, 片岡一則
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-07-03
    • Description
      【発表確定】
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] DNA/RNA Heteroduplex Oligonucleotide as a New Class of Oligonucleotide2015

    • Author(s)
      Takanori Yokota
    • Organizer
      第7回Asia TIDES
    • Place of Presentation
      大阪
    • Year and Date
      2015-03-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] A new therapeutic oligonucleotide to regulate the blood-brain barrier2015

    • Author(s)
      H. Kuwahara, T. Shimoura, J. Song, KY. Tanaka, K. Nishina, T. Nagata, T. Yokota
    • Organizer
      11th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      Stadsgehoorzaal Leiden (Leiden, Netherland)
    • Year and Date
      2015-10-14
    • Description
      【発表確定】
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Creation of hypoxia specific oligonucleotide therapeutics system with intracellular environment-responsible Peptide Ribonucleic Acids (PRNAs): ― Tuning of on - off switching pH of PRNA for optimization of hypoxia cell specificity2015

    • Author(s)
      Asai M, Uematsu R, Araki Y, Nakamoto S, Ishibashi S, Yokota T, Wada T
    • Organizer
      Campus Asia Summer School Symposium 2015
    • Place of Presentation
      Tohoku Univ, Sendai, Japan
    • Year and Date
      2015-08-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing2015

    • Author(s)
      T. Yokota
    • Organizer
      THE INTERNATIONAL CHEMICAL CONGRESS OF PACIFIC BASIN SOCIETIES (PACIFICHEM2015)
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Description
      【発表確定】
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 核酸医薬創薬の問題点と今後の方向性2015

    • Author(s)
      横田隆徳
    • Organizer
      日本化学会第95春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Heteroduplex oligonucleotide (HDO) : efficient drug delivery and processing mechanism.2015

    • Author(s)
      K. Yoshioka, KY. Tanaka, W. Piao, T. Nishina, H. Kuwahara, K. Nishina, T. Yokota
    • Organizer
      11th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Place of Presentation
      Stadsgehoorzaal Leiden (Leiden, Netherland)
    • Year and Date
      2015-10-13
    • Description
      【発表確定】
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Creation of the hypoxia-specific oligonucleotide therapeutics system with intracellular environment-responsible peptide ribonucleic acids (PRNAs): Synthesis and antisense activities of new type of chimeric PRNA-DNA derivatives containing phosphoramidate linkage in PRNADNA junction2015

    • Author(s)
      M. Inagaki, R. Uematsu, Y. Araki, S. SAKAMOTO, S. Ishibashi, H. Kashida, H. Asanuma, T. Yokota, T. Wada
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 生体界面と人工核酸の相互作用細胞膜透過性向上を指向したアルギニン残基導入とその効果2015

    • Author(s)
      菅井 祥加、上松 亮平、中瀬 生彦、坂本 清志、荒木 保幸、高井 まどか、石橋 哲、横田 隆徳、和田 健彦
    • Organizer
      生理研研究会「生体界面研究会」シンポジウム
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2015-07-16
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 細胞内環境応答性ペプチドリボ核酸(PRNA)を利用したハイポキシア特異的核酸医薬の創製2015

    • Author(s)
      上松亮平, 浅井光夫, 稲垣雅仁, 荒木保幸, 坂本清志, 石橋哲, 横田隆徳, 和田健彦
    • Organizer
      第1回核酸医薬学会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-11-30
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] 血液脳関門を通過する脳への新規ドラッグデリバリーシステム2014

    • Author(s)
      新田佳子, 桑原宏哉, 安楽泰孝, 福里優, 溝口明祐, 仁科一隆, 片岡一則, 横田隆徳
    • Organizer
      アンチセンス・遺伝子・デリバリーシンポジウム2014
    • Place of Presentation
      東京医科歯科大学(東京都文京区)
    • Year and Date
      2014-09-09
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 新規二本鎖ヘテロキメラ構造によるマイクロRNA抑制薬の増強効果.2014

    • Author(s)
      吉岡耕太郎, 筋野裕美子, 田中規恵, 朴文英, 仁科智子, 桑原宏哉, 仁科一隆, 横田隆徳.
    • Organizer
      第6回日本RNAi研究会
    • Place of Presentation
      広島
    • Year and Date
      2014-08-28
    • Data Source
      KAKENHI-PROJECT-26670054
  • [Presentation] Development of BBB-targeting nucleic acid medicine2014

    • Author(s)
      Hiroya Kuwahara, Takanori Yokota
    • Organizer
      第37回日本神経科学大会(Neuroscience 2014)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 効率的に血液脳関門を通過する高分子ミセルの開発2014

    • Author(s)
      安楽泰孝, 福里優, 溝口明祐, 石井武彦, 藤加珠子, 松本有, 桑原宏哉, 横田隆徳, 片岡一則
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶應義塾大学(東京都港区)
    • Year and Date
      2014-07-31
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 高効率に脳血液関門を通過するスマートナノマシンの開発2014

    • Author(s)
      安楽泰孝, 福里優, 溝口明祐, 石井武彦, 藤加珠子, 松本有, 桑原宏哉, 横田隆徳, 片岡一則
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-05-29
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 全身投与による中枢神経系へのドラッグデリバリーシステムの開発2014

    • Author(s)
      桑原宏哉, 仁科一隆, 田中規恵, 仁科智子, 朴文英, 水澤英洋, 横田隆徳
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] リガンド搭載高分子ミセル型ナノキャリアを用いた組織特異的核酸デリバリー2014

    • Author(s)
      宮田完二郎, 安楽泰孝, 横田隆徳, 片岡一則
    • Organizer
      第33回日本認知症学会学術会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 画期的な新規核酸医薬の分子技術の創出2014

    • Author(s)
      横田隆徳
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県名古屋市)
    • Year and Date
      2014-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] 高分子ミセルを用いた血液脳関門を通過する革新的技術開発2014

    • Author(s)
      安楽泰孝, 福里優, 溝口明宏, 石井武彦, 松本有, 籐加珠子, 桑原宏哉, 新田佳子, 横田隆徳, 片岡一則
    • Organizer
      第36回日本バイオマテリアル学会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2014-11-18
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Efficient in vivo delivery of antisense oligonucleotide to choroid plexus2013

    • Author(s)
      K. Nishina, P. Wenying, K. Y. Tanaka, T. Nishina, H. Kuwahara, H. Mizusawa, T. Yokota
    • Organizer
      10th International Conference on Cerebral Vascular Biology (CVB2013)
    • Place of Presentation
      Montréal science centre (Montréal, Canada)
    • Year and Date
      2013-06-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein2013

    • Author(s)
      H. Kuwahara, K. Nishina, K. Y. Tanaka, T. Nishina, P. Wenying, H. Mizusawa, T. Yokota
    • Organizer
      10th International Conference on Cerebral Vascular Biology (CVB2013)
    • Place of Presentation
      Montréal science centre (Montréal, Canada)
    • Year and Date
      2013-06-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-25000006
  • [Presentation] Regional cytoplasmic TDP-43 mislocalization is recapitulated in non-human primate mimicking ALS2012

    • Author(s)
      Mizusawa H, Sasaguri H, Ohkubo T, Yokota T
    • Organizer
      The64th AAN Anuual Meeting
    • Place of Presentation
      Morial Convention Center, New Orleans, USA
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 神経疾患に対する核酸医薬による遺伝子治療2012

    • Author(s)
      横田隆徳
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-24659044
  • [Presentation] ALS霊長類モデルにおけるTDP-43の拡がりPropagation of TDP-43 in non-human primate model of ALS2012

    • Author(s)
      田尻美緒,大久保卓哉,木村展之,川上ちひろ,寺岡静香,内原俊記 ,水澤英洋,横田隆徳.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Propagation of TDP-43 in non-human primate model of ALS2012

    • Author(s)
      Tajiri M, Ohkubo T, Kimura N, Kawakami C, Teraoka S, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      Society for Neuroscience 2012
    • Place of Presentation
      New Orleans
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-Human Primate Model of Amyotrophic Lateral Sclerosis with Cyto-plasmicMislocalization of TDP-432012

    • Author(s)
      Yokota T
    • Organizer
      5th International Symposiumon Primate Research KUNMING 2012
    • Place of Presentation
      Howard Johnson TropicalGarden Plaza Kunming
    • Year and Date
      2012-08-21
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Regional cytoplasmic TDP-43 mislocalization is recapitulated in non-human primate mimicking ALS.2012

    • Author(s)
      Yokota T
    • Organizer
      The 64th AAN Anuual Meeting
    • Place of Presentation
      New Orleans
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] TDP-43過剰発現霊長類モデルにおけるTDP-43の拡がり2012

    • Author(s)
      大久保卓哉,田尻美緒,関口輝彦,笹栗弘貴,木村展之,内原俊記,水澤英洋,横田隆徳
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-23
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 細胞内異常局在を呈した野生型TDP-43過剰発現によるALS霊長類モデル Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      大久保卓哉,内田あずさ,笹栗弘貴,木村展之 ,田尻美緒,久保寺隆行,内原俊 記 ,水澤英洋,横田隆徳
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, Uchida A, Sasaguri H, Kimura N, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 上肢完全麻痺を示した孤発性筋委縮性側索硬化症における脊髄前角細胞でのTDP-43の細胞内局在2011

    • Author(s)
      佐野達彦,大久保卓哉,上野智美,内田あずさ,内原俊記,水澤英洋,横田隆〓.
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 孤発性筋委縮性側索硬化症のラットモデル作製2011

    • Author(s)
      大久保卓哉, 田尻美緒, 内田あずさ,須永史子, 平井高志, 澁谷和幹, 金井数明, 桑原聡 , 水澤英洋, 横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-typeTDP-432011

    • Author(s)
      Yokota T
    • Organizer
      The 63rd AANAnnual Meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2011-04-14
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 上肢完全麻痺を示した孤発性筋委縮性側索硬化症における脊髄前角細胞でのTDP-43の細胞内局在2011

    • Author(s)
      佐野達彦, 上野智美, 内田あずさ, 内原俊記, 大久保卓哉, 水澤英洋, 横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 細胞内異常局在を呈した野生型TDP-43過剰発現によるALS霊長類モデルNon-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      大久保卓哉, 内田あずさ, 笹栗弘貴, 木村展之, 田尻美緒, 久保寺隆行, 内原俊記, 水澤英洋, 横田隆徳
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 細胞内異常局在を呈した野生型TDP-43過剰発現によるALS霊長類モデルNon-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      大久保卓哉, 内田あずさ, 笹栗弘貴, 木村展之, 田尻美緒, 久保寺隆行, 内原俊記, 水澤英洋, 横田隆徳
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] 上肢完全麻痺を示した孤発性筋委縮性側索硬化症における脊髄前角細胞でのTDP-43の細胞内局在2011

    • Author(s)
      佐野達彦, 上野智美, 内田あずさ, 内原俊記, 大久保卓哉, 水澤英洋, 横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, Uchida A, Sasaguri H, Kimura N, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-typeTDP-432011

    • Author(s)
      Yokota T
    • Organizer
      The 63^<rd> AAN Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2011-04-14
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, UchidaA, Sasaguri H, Kimura N, Mizusawa H, Yokota T.
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, Uchida A, Sasaguri H, Kimura N, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] TDP-43の断片化とリン酸化はALS霊長類モデルの運動ニューロン変性に必要ではないThe truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      田尻美緒, 坂上史佳, 大久保卓哉, 内田あずさ, 笹栗弘貴, 木村展之, 水澤英洋, 横田隆徳
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] 孤発性筋委縮性側索硬化症のラットモデル作製2011

    • Author(s)
      大久保卓哉, 田尻美緒, 内田あずさ, 須永史子, 平井高志, 澁谷和幹, 金井数明, 桑原聡, 水澤英洋, 横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T.
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 上肢完全麻痺を示した孤発性筋委縮性側索硬化症における脊髄前角細胞での TDP-43 の細胞内局在2011

    • Author(s)
      佐野達彦, 上野智美, 内田あずさ, 内原俊記 , 大久保卓哉, 水澤英洋, 横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] TDP-43過剰発現による孤発性ALSモデルの作製2011

    • Author(s)
      横田隆〓,内田あずさ,笹栗弘貴,田尻美緒,佐野達彦,内原俊記,大久保卓哉,水澤英洋
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-typeTDP-432011

    • Author(s)
      Yokota T
    • Organizer
      The 63rd AAN Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2011-04-14
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] TDP-43過剰発現による孤発性ALSモデルの作製2011

    • Author(s)
      横田隆徳, 内田あずさ, 笹栗弘貴, 田尻美緒, 佐野達彦, 内原俊記, 大久保卓哉, 水澤英洋
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] TDP-43強制発現動物モデルにおける病理・電気生理2011

    • Author(s)
      横田隆徳
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PUBLICLY-23110505
  • [Presentation] 孤発性筋委縮性側索硬化症のラットモデル作製(第2報)2011

    • Author(s)
      大久保卓哉,田尻美緒,須永史子,平井高志,澁谷和幹,金井数明,桑原聡,水澤英洋,横田隆〓.
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] AAVベクターを用いた野生型TDP-43:過剰発現による筋萎縮性側索硬化症サルモデルの作製2010

    • Author(s)
      笹栗弘貴, 渡邊あずさ, 西本美香, 久保寺隆行, 内原俊記, 水澤英洋, 横田隆徳
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム (東京都)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] RNA干渉の神経系への臨床応用2009

    • Author(s)
      横田隆徳
    • Organizer
      第26回日本神経治療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Presentation] RNA干渉を用いた遺伝子治療2009

    • Author(s)
      横田隆徳
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-03-18
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Presentation] RNA干渉を用いた遺伝子治療の現状2009

    • Author(s)
      横田隆徳
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Presentation] RNA干渉を用いた遺伝子治療2009

    • Author(s)
      横田隆徳
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Presentation] RNA干渉によるALSの治療戦略2009

    • Author(s)
      横田隆徳
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-21
    • Data Source
      KAKENHI-PROJECT-20023010
  • [Presentation] アルツハイマー病におけるAβクリアランスへの酸化ストレスの影響2008

    • Author(s)
      西田陽一郎, 横田隆徳, 他
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-20650054
  • [Presentation] Oxidative stress increases Ap accumulation by decreasing its clearance in a mouse model of Alzheimer disease2008

    • Author(s)
      Nishida Y, Yokota T, etal.
    • Organizer
      31st Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20650054
  • [Presentation] Efficient in vivo delivery of siRNA to liver by conjugation of a-toco pherol.2008

    • Author(s)
      Yokota T, Unno T, Nishina K, Uno Y, Kubodera T, Kanouchi T, Mizusawa H:
    • Organizer
      Keystone Symposim, RNAi, miRNA and non-coding RNA
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Transgenic siRNA halts ALS in a mouse model.2007

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Mitani T, Mizusawa H.
    • Organizer
      59th Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Boston, MA(米国)
    • Year and Date
      2007-05-04
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Tranegenic siRNA holts ALS in a mouse model.2007

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Mitani T, Mizusawa H
    • Organizer
      59th AAN annual meeting
    • Place of Presentation
      Boston
    • Year and Date
      2007-05-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.2007

    • Author(s)
      Yoshida T, Yokota T, Li Y, GamaV, Gomez J, Ishikawa K, SasaguriH, Mizusawa H, Matsuyama S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience.
    • Place of Presentation
      San Diego, CA(米国)
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Tranegenic siRNA halts ALS in a mouse model.2007

    • Author(s)
      Yokota T, et. al.
    • Organizer
      59th Annual Meeting of Am Acad of Neurology
    • Place of Presentation
      Boston
    • Year and Date
      2007-05-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] A new RNAi strategy for selective suppression of a mutant allele to any mutation.2007

    • Author(s)
      Yamada H, Kubodera T, Yokota T, Mizusawa H.
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Gene Therapy of Hereditary Diseases with RNA Interference.2007

    • Author(s)
      横田隆徳, 久保寺隆行, 山田宏美, 海野敏紀, 仁科一隆, 三谷 匡, 水澤英洋.
    • Organizer
      第30回日本分子生物学会年会, 第80回日本生化学学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] A New RNA Strategy For Selective Suppression of a Mutant Allele to any Mutation.2007

    • Author(s)
      山田宏美, 久保寺隆行, 横田隆徳, 水澤英洋.
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-30
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] In vivo application of RNA interference.2007

    • Author(s)
      Yokota T.
    • Organizer
      Neuro2007(第30回日本神経科学大会、第50回日本神経化学大会、第17回日本神経回路学会大会、合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] LIVER TOXICITY INDUCED BY AAV-DELIVERED SHORT HAIEPINRNA(shRNA).2007

    • Author(s)
      海野俊紀、久保寺隆行、村山祥子、大平進嘉、李一、仁科一隆、猪狩亨、江石義信、平井幸彦、島田隆、横田隆徳、水澤英洋
    • Organizer
      日本遺伝子治療学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19659222
  • [Presentation] Gene Therapy of Hereditary Diseases with RNA Interference.2007

    • Author(s)
      横田隆徳, 他
    • Organizer
      第30回日本分子生物学会年会, 第80回日本生化学学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Clinical application of siRNA.2007

    • Author(s)
      Yokota T
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] shRNA発現アデノ随伴ウイルスベクターを用いた遺伝子治療の可能性2007

    • Author(s)
      久保寺隆行、横田隆徳、水澤英洋
    • Organizer
      日本神経学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19659222
  • [Presentation] Liver toxicity induced by AAV-delivered short hairpin RNA.2007

    • Author(s)
      Unno T, Kubodera T, Murayama S, Ohira S, Nishina K, Igari T, Eishi Y, Hirai Y, Shimada T, Yokota T, Mizusawa H
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Transgenic siRNA halts ALS in mouse model2007

    • Author(s)
      Yokota T, et. al.
    • Organizer
      59th Annual Meeting of the Am Acad of Neurology
    • Place of Presentation
      Boston
    • Year and Date
      2007-05-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Adeno-associated virus serotype 8(AAV-8)mediated shRNA delivery in vivo.2006

    • Author(s)
      Chen Y, Yokota T, Kubodera T, Ohnishi I, Li Y, Nishina K, Hirai Y, Shimada T, Mizusa wa H.
    • Organizer
      第12回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2006-08-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Tranegenic siRNA holts ALS in a mouse model.2006

    • Author(s)
      Yokota T, Sasaguri H, Saito Y, Mitani T, Mizusawa H
    • Organizer
      Neuro2006
    • Place of Presentation
      Atanta
    • Year and Date
      2006-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Efficient regulation of viral replication by systemically administered siRNA in a non-human primate surrogate model for hepatitis.2006

    • Author(s)
      Yokota T, Iijima S, Kubodera T, Ishii K, Ageyama N, Yingwei C, Lee J-J, Maki N, Mizusawa H, Akari H
    • Organizer
      第12回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Efficient delivery of siRNA targeting brain endothelial cells.2006

    • Author(s)
      Nishina K, Yokota T, Hino T, Yoshida M, Terasaki T, Mizusawa H
    • Organizer
      第12回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2006-08-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] In vivo application of siRNA/shRNA.2006

    • Author(s)
      Yokota T
    • Organizer
      Bio-Japan Symposium
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2006-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] In vivo analysis of new RNAi strategy; selective suppression of a mutant allele to any mutation.2006

    • Author(s)
      Kubodera T, Yokota T, Saito Y, Mizusawa H
    • Organizer
      第12回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Transgenic siRNA halts ALS in mouse model2006

    • Author(s)
      Yokota T, et. al.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Year and Date
      2006-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] siRNAの静脈注射によるC型肝炎の遺伝子治療:サルを用いたC型肝炎サロゲートモデルによる検討2006

    • Author(s)
      横田隆徳, 久保寺隆行, 平林加寿子, 石井孝司, 愼 昇, 水澤英洋, 榎本信幸, 矢野純一, 明里宏文
    • Organizer
      第20回日本肝臓学会
    • Place of Presentation
      京都
    • Year and Date
      2006-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Efficient regulation of viral replication by systemically administered siRNA in a non-human primate surrogate model for hepatitis C.2006

    • Author(s)
      Yokota T, Kubodera T, Unno N, Chen Y, Nishina K, Mizusawa H, Akari H
    • Organizer
      12th annual meeting of Japan Society of Gene Therapy 2006
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-08-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390215
  • [Presentation] Transgenic siRNA halts ALS in mouse model.2006

    • Author(s)
      Yokota T, et. al.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Year and Date
      2006-10-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] RNA干渉と神経疾患、神経変性疾患の最新の原因・病態解析.2005

    • Author(s)
      横田隆徳.
    • Organizer
      第46回日本神経学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2005-05-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] siRNAを用いた家族性アミロイドニューロパチーに対する遺伝子治療.2005

    • Author(s)
      横田隆徳, 他
    • Organizer
      第46回日本神経学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2005-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] siRNAを用いた変異SOD1によるALSの変異遺伝子特異的な遺伝子治療.2005

    • Author(s)
      横田隆徳, 他
    • Organizer
      第23回日本神経治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] siRNAの神経疾患への応用.2005

    • Author(s)
      横田隆徳.
    • Organizer
      第16回フオーラム・イン・ドージン
    • Place of Presentation
      熊本
    • Year and Date
      2005-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] Transgenic siRNA halted amyotrophic lateral sclerosis in a mouse model.2005

    • Author(s)
      Yokota T, Mizusawa H.
    • Organizer
      11th Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      東京
    • Year and Date
      2005-07-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] トランスレーショナルニューロサイエンス-難病ALSへの神経科学の挑戦-siRNAによるALSの遺伝子治療.2005

    • Author(s)
      横田隆徳.
    • Organizer
      第28回日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] 神経変性疾患は細胞死か?2005

    • Author(s)
      横田隆徳.
    • Organizer
      第24回六甲カンファレンス
    • Place of Presentation
      淡路
    • Year and Date
      2005-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
  • [Presentation] WIP1401 Non-Human Primate Model of Amyotrophic Lateral Sclerosis with Cytoplasmic Mislocalization of TDP-43

    • Author(s)
      Ohkubo T, Tajiri M, Uchida A, Kimura N, Sasaguri N, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      2012Annual Meeting of the AmericanNeurological Association
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] Non-Human Primate Model of Amyotrophic Lateral Sclerosis with Cyto-plasmicMislocalization of TDP-43.

    • Author(s)
      Yokota T
    • Organizer
      5th International Symposium on Primate Research KUNMING 2012
    • Place of Presentation
      Kunming
    • Invited
    • Data Source
      KAKENHI-PROJECT-22240039
  • [Presentation] 次世代核酸医薬の創出

    • Author(s)
      横田隆徳
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2015-05-21
    • Data Source
      KAKENHI-PROJECT-26282136
  • [Presentation] Transgenic siRNA halted amyotrophic lateral sclerosis in a mouse model

    • Author(s)
      Yokota T, Mizusawa H.
    • Organizer
      11th Annual Meeting of Japan Society of Gene therapy
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209031
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    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 2.  UCHIHARA Toshiki (10223570)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 18 results
  • 3.  MIZUSAWA Hidehiro (30144091)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 4.  INABA Akira (10282766)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  久保寺 隆行 (40376801)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 6.  OHKUBO Takuya (90587461)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 7.  TSUMOTO Kouhei (90271866)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MIYATA Kanjiro (50436523)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 9.  INOUE Keizo (30072937)
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    # of Collaborated Products: 0 results
  • 10.  ISHIKAWA Kinya (30313240)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 11.  AKARI Hirofumi (20294671)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 12.  ENOMOTO Nobuyuki (20251530)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 13.  Nagata Tetsuya (50362976)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 14.  URUSHIDANI Makoto (60332326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KIMURA Nobuyuki (80392330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 16.  KUWABARA Satoshi (70282481)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  HIGUCHI Osamu (50361720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ISHIBASHI SATORU (30533369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 25 results
  • 19.  KATAOKA Kazunori (00130245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 20.  ITAKA Keiji (60292926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OSADA Kensuke (10396947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Ishii Takehiko (80415075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 23.  NISHIYAMA Nobuhiro (10372385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ANRAKU Yasutaka (60581585)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 25.  MATSUMOTO Yu (80548553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 26.  UCHIDA Satoshi (20710726)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  SAITO Yukinobu (80302842)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KIYOSAWA Motohiro (20169957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  WATASE Kei (30376800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  道川 誠 (40270912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  和田 義明 (50182986)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 14 results
  • 35.  大和田 潔 (40313241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  常深 泰司 (50401344)
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 11 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
  • 42.  足立 善昭 (80308585)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  西田 陽一郎 (40444111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  中山 東城 (40613302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  東 美和 (30898185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  吉岡 耕太郎 (70780641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  SOTOME Shinichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 48.  ENOMOTO Mitsuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 49.  YOSHIDA Mari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  馬渕 洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  大川 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 52.  和田 猛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 53.  内藤 瑞
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 54.  松原 悦朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 55.  小比賀 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 56.  浅田 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  井原 健介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  松村 浩由
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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